This page gives access to the study data. The data set is available in two forms:
There are three ways to query the data set:
- Clinical and summary data: Tables containing clinical information (viral load, CD4+ counts, HLA types, estimates of time of infection), the patient reference sequence for mapping, and the single nucleotide variant (SNP) frequency tables.
- Haplotypes: Extended genetic variants, including minor ones, covering standard or custom genomic regions.
- Sequencing reads: The filtered sequencing reads, mapped against the single fragments of the patient-specific reference. Download the genbank (GB) version of the reference to find PCR fragment annotations.
- Counts of pairs of SNPs: The counts of pairs of single nucleotide polymorphisms, for each sample and amplicon. These data are useful to investigate linkage.
The API is used for online analysis or embedding into another website. See
below for details.


Bayern say no to Wenger for vacant manager's post
Munich - Bayern Munich have turned down an approach from Arsene Wenger to take over the vacant manager's position following the sacking of Niko Kovac, the German champions said on Thursday.
"Arsene Wenger called (Bayern chairman) Karl-Heinz Rummenigge on Wednesday afternoon to make him aware of his interest in the job," a Bayern spokesperson told AFP subsidiary SID.
"Bayern appreciates Wenger's work at Arsenal, but he is not being considered as coach."
Kovac was dismissed at the weekend following a poor run of form that culminated in a 5-1 thrashing at the hands of Eintracht Frankfurt, Bayern's worst Bundesliga defeat in a decade and one which left them fourth in the table.
Kovac's assistant Hansi Flick has taken over as interim coach as Bayern search for a more permanent replacement, with club president Uli Hoeness saying on Tuesday they expected to name Kovac's successor by November 23.
However they have been publicly rebuffed by both Paris Saint-Germain boss Thomas Tuchel and Ajax's Erik ten Hag, who said on Monday he would be staying with the Dutch champions until at least the end of the season.


Winston's Website
How to be Pretentious
- Make an entire website about yourself
- Make the background black and edgy
- Make the entire website without javascript
- Purposefully disobey instructions and make website several
webpages
- Add a uselessly animated item
- Add weird hard to read fonts
- Add an invisible list item
A Random Rant About The Word Orange
Why did we make the word orange? That word is so confusing! Why is it both
a fruit and a color? Did someone just look at a color, and decide to name
a fruit based off of it? Who thinks that our collection of colors is a
repository to go looking for a name for a fruit? What do those things have
to do with one another?
Why does this persist in other languages too?
Shouldn't there be a point where one person looks at the fruit, and goes:
"this is stupid, why do we keep on doing this? Just because an orange is
orange, doesn't mean we should call it that." How could we as a society
screw this up that badly? I believe that this is enough reason to call
a state of emergency in order to solve this crisis before it becomes a
lost cause.
Scandelous Secrets About Robotics
Despite our robotics team being objectively the best club in the entirety
of Stuyvesant, there are some things that we do that is probably less than
ideal. For instance, we dab way too much for no reason. We have made
our own dabbing emoji, and a picture of one of us dabbing got onto a news
outlet in China. However, the reason why we do this is because we want to
raise awareness for the cancer patients in Antartica.
Things I Did Today
- I got dressed
- I did my chores
- I completed my science homework
- I most definitely did my chores
- I ate food
- I didn't actually do my chores
The uselessly animated item


AN AMERICAN WEREWOLF IN LONDON (1981) A Film Review by Ted Prigge Copyright 1997 Ted Prigge
Writer/Director: John Landis Starring: David Naughton, Jenny Agutter, Griffin Dunne
With the upcoming "An American Werewolf in Paris" coming out Christmas Day (and looking way too hokey rather than comical), I thought I'd finally check out "An American Werewolf in London," the original film, and one of comical director John Landis's first. What it does is take the old melodramatic horror films and kinda mocks them with great black comedy. Still, it has its flaws.
"An American Werewolf in London" (great title) deals with two Americans David and Jack (David Naughton and Griffin Dunne, respectively) who go to London to bum around Europe, get laid, etc. They are dropped off after a bit of hitch-hiking around the moors, where they meet some creepy brits, who mysteriously warn them to "beware the moon" and "stay away from the moors." They kind of laugh at this (once they're out of there, of course), and soon find themselves off the main road, and near the moors...and with a full moon out. Soon enough, they are attacked by a giant wolf, who slaughters Jack, and merely wounds David, before it is shot by the villagers, and subsequently turns into a human.
David awakes from a coma, and has a series of nightmares, fantasies, etc, including one where a decomposing Jack visits him, and tells him to commit suicide since he's a werewolf...and once he dies, he can actually go on to the next life. But David has soon fallen in love with his nurse (Jenny Agutter, from "Logan's Run"), and just thinks he is going insane. Then one night, he turns into a werewolf...
The chief positive note about "An American Werewolf in London" is the humor...and the effects. If you've ever seen a John Landis film ("Animal House," "The Blues Brother"), you know he has a cool sense of humor. Here, it's very dark, as he finds humor from almost anything. So we don't take this seriously, he places cool ironic oldies on the soundtrack, including a couple different versions of "Blue Moon," and at one instance, CCR's "Bad Moon Rising." This makes us kind of grin at the whole thing, even when David is a werewolf and chasing people around London.
The effects are also quite amazing. The legendary Rick Baker (who also worked on "Men in Black") did the creature effects, including the greatest mutation-into-a-wolf scene in celluloid history (how many of those have you seen?). It's disgusting, humorful, and just plain cool all at the same time, and even look realistic. I mean, this was made in 1981, and David Naughton's hand is shown actually growing. And for you Michael Jackson fans, there's a shot of hair growing behind ears that was used in the "Thriller" video (also directed by Landis).
The acting's good, especially from Naughton, who's great and comical in the title role, as well as very likable. Griffin Dunne all but steals the film, but what else would you expect from the man who created the Kafka-stare (in "After Hours"). Jenny Agutter does a good job too, as the nurse who takes David in to her house, and subsequently screws around with him a bit.
But as I said, the film is still flawed. The film is way too short, seeming to be afraid to expand on any themes it presents. At roughly 90 minutes, the film moves slowly for the first hour, then speeds up in the final 30 minutes, which is when he first changes into the wolf. There isn't any real depth to the film, even with the romance between Agutter and Naughton, even if they have fairly good chemistry. And the ending is almost anti-climactic and ends way too quickly. Sure the second the credits role, I laughed, but it ends on way too serious a note.
Still, "An American Werewolf in London" is an 80s classic (not a bad thing, believe me), and still a very entertaining little flick. The new one looks way too over-produced and effects-y. This one uses the effects perfectly, without overcoming the story. I personally believe that minimalism would be the best thing to use with this film, and I'm glad that Landis could make a good film, even if he hasn't made one now in awhile.
MY RATING (out of 4): ***
Homepage at: http://www.geocities.com/Hollywood/Hills/8335/
The review above was posted to the
rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).
The Internet Movie Database accepts no responsibility for the contents of the
review and has no editorial control. Unless stated otherwise, the copyright
belongs to the author.
Please direct comments/criticisms of the review to relevant newsgroups.
Broken URLs inthe reviews are the responsibility of the author.
The formatting of the review is likely to differ from the original due
to ASCII to HTML conversion.
Related links: index of all rec.arts.movies.reviews reviews


In order to run examples you have to setup your video source url (search for VIDEO_URL
string) in:
| Simple example | Just clappr. |
| Plugins example | Couple of plugins enabled (like responsive container etc). |
| Events example | Example event handlers should log to the console. |


{% extends "page.html" %} {# This template is rendered in response to an authenticated request, so the user is technically logged in. But when the user sees it, the cookie is cleared by the Javascript, so we should render this as if the user was logged out, without e.g. authentication tokens. #} {% set logged_in = False %} {% block stylesheet %} {% endblock %} {% block site %}


Press the button to generate random PaymentID or enter Payment ID to decode it
Enter short memo to encode it (ASCII only)
Payment ID is optional transaction attachment that is usually used to identify transactions. Because of anonymity of MONCoin transactions, without Payment ID you will not be able to distinguish them. You can generate random Payment IDs and give them to each user who is to send you some MONCoin. This way you can tie payments to users.
You can also encode some short text into Payment ID.


Mother says one-punch attack that killed her son should act as a warning
by Michael StainesThe mother of a Longford man who died in a one-punch attack in New York has said she appreciates the remorse expressed by the man that assaulted him.
21-year-old Danny McGee from Drumlish in County Longford was found unresponsive outside a pub in Queens on November 22nd last year.
He was taken to hospital but later pronounced dead.
At Queens County Criminal Court yesterday, Dubliner Steven O’Brien pleaded guilty to the assault.
Prosecutors told the court he punched Mr McGee once to the side of the head during an argument.
The 26-year-old, with an address at 42nd Street in Queens, will serve six months in prison after agreeing a plea deal.
He apologised to Mr McGee’s family and his lawyer told the court that he is remorseful and sad over the tragedy.
On Newstalk Breakfast with Susan Keogh this morning, Mr McGee mother Colleen McGee said she appreciates the sentiment.
“I don’t know Steven O’Brien; I never heard his name before,” she said.
“I hope it was sincere and heartfelt and if it was, I appreciate that he did it.”
"Heartbroken"
She said her family remains “heartbroken” as the anniversary of the attack passes.
“He has a younger brother and younger sister and they both looked up to him. We all missed him so much while he was away.
“He had decided he was going to return home in February of this past year. While he did love New York, he had a very tight circle of friends and he missed that. He missed home.
“Naturally we were looking forward to him coming home in a few months and unfortunately that wasn’t to be.”
Justice
She said a little bit of justice was served for her son.
“He pleaded guilty and will serve a little bit of time and after a few months, he will go and – I assume – put it behind him and get on with his life.”
“That is not an option for us but a little bit of justice was served for Danny yesterday.”
"Just walk away"
She said the incident should act as a warning to anyone about the dangers of violence.
“I never knew Danny to have a physical fight with anybody,” she said.
“I always taught himself and his brother from when they were young boys to keep your hands to yourself. If you ever become involved in a situation please just walk away.
“And in the heat of the moment, as I said I don’t know really what happened, but one punch, it ended his young life. He had so much to look forward to.”
The Longford Association of New York is holding a special mass for Danny this afternoon.
A further mass will be held in Drumlish, County Longford on December 14th.
You can listen back to Colleen's conversation with Susan Keaogh here:


Back-off options for creating a back-off supervisor actor that expects a child actor to restart on failure.
Back-off options for creating a back-off supervisor actor that expects a child actor to restart on failure.
This explicit supervisor behaves similarly to the normal implicit supervision where
if an actor throws an exception, the decider on the supervisor will decide when to
Stop
, Restart
, Escalate
, Resume
the child actor.
When the Restart
directive is specified, the supervisor will delay the restart
using an exponential back off strategy (bounded by minBackoff and maxBackoff).
This supervisor is intended to be transparent to both the child actor and external actors.
Where external actors can send messages to the supervisor as if it was the child and the
messages will be forwarded. And when the child is Terminated
, the supervisor is also
Terminated
.
Transparent to the child means that the child does not have to be aware that it is being
supervised specifically by this actor. Just like it does
not need to know when it is being supervised by the usual implicit supervisors.
The only caveat is that the ActorRef
of the child is not stable, so any user storing the
sender()
ActorRef
from the child response may eventually not be able to communicate with
the stored ActorRef
. In general all messages to the child should be directed through this actor.
An example of where this supervisor might be used is when you may have an actor that is responsible for continuously polling on a server for some resource that sometimes may be down. Instead of hammering the server continuously when the resource is unavailable, the actor will be restarted with an exponentially increasing back off until the resource is available again.
***
This supervisor should not be used with Akka Persistence
child actors.
Akka Persistence
actors shutdown unconditionally on persistFailure()
s rather
than throw an exception on a failure like normal actors.
#onStop should be used instead for cases where the child actor
terminates itself as a failure signal instead of the normal behavior of throwing an exception.
***
You can define another
supervision strategy by using akka.pattern.BackoffOptions.withSupervisorStrategy
on akka.pattern.BackoffOptions.
the akka.actor.Props of the child actor that will be started and supervised
name of the child actor
minimum (initial) duration until the child actor will started again, if it is terminated
the exponential back-off is capped to this duration
after calculation of the exponential back-off an additional
random delay based on this factor is added, e.g. 0.2
adds up to 20%
delay.
In order to skip this additional delay pass in 0
.
Back-off options for creating a back-off supervisor actor that expects a child actor to stop on failure.
Back-off options for creating a back-off supervisor actor that expects a child actor to stop on failure.
This actor can be used to supervise a child actor and start it again after a back-off duration if the child actor is stopped.
This is useful in situations where the re-start of the child actor should be delayed e.g. in order to give an external resource time to recover before the child actor tries contacting it again (after being restarted).
Specifically this pattern is useful for persistent actors, which are stopped in case of persistence failures. Just restarting them immediately would probably fail again (since the data store is probably unavailable). It is better to try again after a delay.
It supports exponential back-off between the given minBackoff
and
maxBackoff
durations. For example, if minBackoff
is 3 seconds and
maxBackoff
30 seconds the start attempts will be delayed with
3, 6, 12, 24, 30, 30 seconds. The exponential back-off counter is reset
if the actor is not terminated within the minBackoff
duration.
In addition to the calculated exponential back-off an additional
random delay based the given randomFactor
is added, e.g. 0.2 adds up to 20%
delay. The reason for adding a random delay is to avoid that all failing
actors hit the backend resource at the same time.
You can retrieve the current child ActorRef
by sending BackoffSupervisor.GetCurrentChild
message to this actor and it will reply with akka.pattern.BackoffSupervisor.CurrentChild
containing the ActorRef
of the current child, if any.
The BackoffSupervisor
delegates all messages from the child to the parent of the
BackoffSupervisor
, with the supervisor as sender.
The BackoffSupervisor
forwards all other messages to the child, if it is currently running.
The child can stop itself and send a akka.actor.PoisonPill to the parent supervisor if it wants to do an intentional stop.
Exceptions in the child are handled with the default supervisionStrategy, which can be changed by using
BackoffOptions#withSupervisorStrategy or BackoffOptions#withDefaultStoppingStrategy.  A Stop
will
stop the child, but it will be started again after the back-off duration.
the akka.actor.Props of the child actor that will be started and supervised
name of the child actor
minimum (initial) duration until the child actor will started again, if it is terminated
the exponential back-off is capped to this duration
after calculation of the exponential back-off an additional
random delay based on this factor is added, e.g. 0.2
adds up to 20%
delay.
In order to skip this additional delay pass in 0
.
Builds back-off options for creating a back-off supervisor. You can pass
BackoffOptions
toakka.pattern.BackoffSupervisor.props
. An example of creating back-off options:


E-mail Password Save password Use own cloud server
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Please enter the master password for this app. Master Password
Master Password Master Password (Confirm) Please make sure you remember the Master Password you have set.


View the source of this web page. Copy all. Paste into local
editor. Save as JokeChecklist.html. Edit. Verify the appearance with your
browser. Submit to D2L.
Required, precisely named submission files, NO
subdirectories, NO Packages:
Change "No" to "Yes" as you complete the tasks:
Task
Complete?
My name is...
Amad Ali
InetServer.java, InetClient.java and InetChecklist.html (this file) submitted to D2L as standard ZIP file
No
All Inet java code concatenated together
and submitted to D2L Inet TII link as .docx or .html only (For
practice—will show high score.) No
All files named correctly (see above)
Yes
All files in ONE directory (no subdirs, no java packages)
No
Followed TII submission link to run plagiarism checker (click on numeral
showing number of submissions).
No
Academic Integrity Quiz completed (required before we grade any work).
Yes
Basic Inet Client and Server Run
Yes
Removed all of Elliott's Inet comments
Yes
Added MY comments to Inet
Yes Optional Comments:
[Communicate with us about this program here if necessary.]
Explain Maybe entries here also.


Adding Feedback Categories
How to add one or more categories to the Feedback module. You can optionally associated categories with one or more email addresses which will sends a notification message to those email addresses whenever feedback is submitted to that category.
Tip: The Feedback Comments module can also be set to display feedback for all categories or just one category.
-
Select Edit > Edit Category/Subject Lists from the module actions menu. This opens the Edit Lists page.
- At List Type, select Categories.
- In the Name text box, enter a name for this category. E.g. Marketing
- In the Value text box, enter a value for this category (E.g. Marketing) to be displayed in the Feedback Comments module beside any feedback within this category - OR - Enter one or more email addresses separated by a semi-colon (;) (E.g. sales<EMAIL_ADDRESS>that will be displayed in the Feedback Comments module beside any feedback within this category.
- At Is Active, if this category will show up in the category list on the Feedback module - OR - if this category is currently inactive.
- At Is Portal Wide, if this category is available to all Feedback modules across this site - OR - if this category is currently inactive.
- Click the Save button. The category is now displayed to the left.
- Repeat Steps 3-7 to add additional categories.
- Click the Return to Module button when you are finished.


[gecode-users] Trigonometric functions in Gecode
Guido Tack
tack at gecode.org
Thu Mar 17 13:05:59 CET 2011
Jonathan Skovhus Andersen wrote:
> Thanks for the quick response Guido!
>
> So what you are basically saying is that there is no way to use trigonometric functions in Gecode at the moment? Isn't there a way make the calculation with floating points first and then casting it somehow?
If it's just for computing parameters of the constraint problem, sure, you can use whatever C++ offers. But you can't use constraint variables (i.e., IntVars) inside any trigonometric expression (I assume the coordinatesArray contains IntVars).
Cheers,
Guido
--
Guido Tack, http://people.cs.kuleuven.be/~guido.tack/
More information about the users
mailing list


Quark v1.0.2 Quark.Partial
Provide curried functions, that can also be partially bound without dot notation. Partially applying a function will always return a fully-curried function.
Please note that these will use all of the arities up to the defined function.
For example, defpartial foo(a, b, c), do: a + b + c
will generate foo/0
, foo/1
,
foo/2
, and foo/3
. If you need to use an arity in the range below the original
function, fall back to defcurry
and partially apply manually.
Summary
Macros
A convenience on defcurry
. Generates a series of partially-bound applications
of a fully-curried function, for all arities at and below the user-specified
arity. For instance, defpartial add(a,b), do: a + b
will generate add/0
,
add/1
and add/2
defpartial
, but generates private functions
Macros
A convenience on defcurry
. Generates a series of partially-bound applications
of a fully-curried function, for all arities at and below the user-specified
arity. For instance, defpartial add(a,b), do: a + b
will generate add/0
,
add/1
and add/2
.
defpartialp minus(a, b, c), do: a - b - c
minus(3, 2, 1)
# => 0
minus.(3).(2).(1)
# => 0
below_ten = minus(5)
below_ten.(2, 1)
# => 7
below_five = minus(20, 15)
below_five.(2)
# => 3


| Home | Trees | Indices | Help |
|
|---|
|
|
|
|||
|
|
|||
__package__ =
|
Imports: os
|
Test whether a path is a mount point clone of os.path.ismount (from cpython Lib/posixpath.py) fixed to solve https://github.com/ansible/ansible-modules-core/issues/2186 and workaround non-fixed http://bugs.python.org/issue2466 this should be rewritten as soon as python issue 2466 is fixed probably check for python version and use os.path.ismount if fixed to remove replace in this file ismount( -> os.path.ismount( and remove this function |
| Home | Trees | Indices | Help |
|
|---|
| Generated by Epydoc 3.0.1 on Fri Jul 29 13:11:37 2016 | http://epydoc.sourceforge.net |


Before Change
raise IncompatibleStateError(
"Parameter "arch.layers" is missing from neural network state.")
// An ugly workaround to be able to save arbitrary data in a .npz file.
try:
dummy_dict = state["arch.layers"][()]
except KeyError:
dummy_dict = state["arch.layers"]
state_layers = dummy_dict["data"]
for layer1, layer2 in zip(self.layers, state_layers):
if layer1["type"] != layer2["type"]:
raise IncompatibleStateError(
After Change
for layer_id, layer in enumerate(self.layers):
h5_layer = h5_layers[str(layer_id)]
for variable, values in layer.items():
if isinstance(values, list):
h5_values = h5_layer[variable]
for value_id, value in enumerate(values):
h5_value = h5_values.attrs[str(value_id)]
if value != h5_value:
raise IncompatibleStateError(
"Neural network state has {0}={1}, while "
"this architecture has {0}={2}.".format(
variable, value, h5_value))
else:
h5_value = h5_layer.attrs[variable]
if values != h5_value:
raise IncompatibleStateError(
"Neural network state has {0}={1}, while "
"this architecture has {0}={2}.".format(
variable, value, h5_value))
def __init__(self, dictionary, architecture, batch_processing=True, profile=False):
Initializes the neural network parameters for all layers, and
creates Theano shared variables from them.


| Name | Description |
|---|---|
| isecdom | Referencing a DOM node in Expression |
| isecff | Referencing 'call', 'apply' and 'bind' Disallowed |
| isecfld | Referencing Disallowed Field in Expression |
| isecfn | Referencing Function Disallowed |
| isecobj | Referencing Object Disallowed |
| isecwindow | Referencing Window object in Expression |
| lexerr | Lexer Error |
| syntax | Syntax Error |
| ueoe | Unexpected End of Expression |


There are two important Rules, which you need to understand if you're working with ES6 Modules: Modules are always in Strict Mode (no need to define "use strict") Modules don't have a shared, global Scope. Instead each Module has its own Scope
Test basics
button
Great links
modern-js-cheatsheet


昨日 {$yestaday.order_count} ,合计 {$total.order_count}
昨日 ¥{$yestaday.order_price} ,合计 ¥{$total.order_price}
昨日 {$yestaday.product_count} ,合计 {$total.product_count}
昨日 {$yestaday.customer_count} ,合计 {$total.customer_count}


?D.S.Correll
¤
F.G.Meyer
44705
Herbarium
FAIRCHILD
TROPICAL
GARDEN
Urban
Great
Abaco:
in
coppice
on
Man-O-War
Cay.
Tall
shrub
3
m
tall.
March
16,
1975
01497747
Legend -
Level of confidence that token is an accurately-transcribed word
extremely low
very low
low
undetermined
medium
high
very high


You currently have no VGI submissions for this season.
Upload a poster or paper
{{poster.submissionType.type}}: {{poster.title}}
You currently have no student presentation or poster competitions for this season.
You currently have not rated any sessions for this season.


THE NASTY GIRL A film review by Ben Hoffman Copyright 1997 Ben Hoffman
When Anja Rosmus researched her hometown's past during the Nazi era she was subjected to all kinds of harassment and death threats, the least of which was being referred to as "that terrible girl". . . or as translated for the film's title, "that nasty girl."
Based on her story of her research and the town's reaction we are treated to a most wonderful film which despite its very serious subject contains much humor. Lena Stolze does a great job as Anja growing from a teenager early in the film to a mother of 2 children.
It starts with Anna's teen years in a Catholic school, her winning a national essay contest and her decision to enter another essay contest picking as her subject, in all innocence, the people of her home town during the Nazi period.
When she begins the research she is surprised to find that she is being thwarted in her every attempt to read the town's, the library's and the church's archives of that period. As she digs into whatever information she can gather she discovers that many of the present day respectable citizens behaved despicably to the Jews, confiscating their property, accusing them of crimes and allowing them to be sent to concentration camps. Although one never hears any talk of that period, Anja discovers that the town even had its own concentration camp.
Very much in a documentary fashion but with a very effective twist, the film's characters will frequently turn to the audience and explain what is happening and the circumstances surrounding their actions. That all of this is done with a light touch to make its point is attributable to the talents of its director. And the point of the film is to show that 50 years later there is still much hidden in the hearts of many Germans, and that among many of the young, Hitler is still an idol.
In German, with English subtitles.
Masterfully directed by Michael Verhoeven
4 bytes
4 bytes = Superb 3 bytes = Too good to miss 2 bytes = Average 1 byte = Save your money
Ben Hoffman
The review above was posted to the
rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).
The Internet Movie Database accepts no responsibility for the contents of the
review and has no editorial control. Unless stated otherwise, the copyright
belongs to the author.
Please direct comments/criticisms of the review to relevant newsgroups.
Broken URLs inthe reviews are the responsibility of the author.
The formatting of the review is likely to differ from the original due
to ASCII to HTML conversion.
Related links: index of all rec.arts.movies.reviews reviews


class: center, middle, inverse, title-slide # Data Integration in Bioinformatics and Biomedicine ###
Alex Sanchez-Pla
, Francesc Carmona, Ferran Reverter, Esteban Vegas, Pol Castellano ### Genetics, Microbiology and Statistics Department (UB)
Statistics and Bioinformatics Unit (VHIR) ### 2021-07-08 --- # Outline .columnwide[ ### 1) [Data, Data-related Projects and Data Science](#Introduction) ### 2) [Integrative Omics Data Analysis](#IODA) ### 3) [Open problems we work in](#IODAProjects) ### 4) [Biomedical data integration and data sharing](#DataSharing) ### 5) [Data Projects we work in](#DataProjects) ### 6) [Looking ahead](#Estrategia) ] --- class: inverse, middle, center name: Introduction # Data, Data-related Projects and
 Data Science  --- # The importance of Data ## Data is essential to solve problems or answer questions - Simplistically, when we wish to solve a problem we collect data - Statistics: Questions --> [Hypothesis] --> Get data - Data Science: Questions --> Get Data - Data availability and complexity increases all the time - More (Big) data --> Better solutions? - 21st century holy grial: - __Data + AI --> Personalized medicine__       --- # From XXth century studies ## Traditional Statistical Analysis .center[  ] --- # To beginning of XXth ## Microarrays: One dataset, _many_ genes ### Efron called the XXIst century "_The century of microarrays_" .center[  ] --- # Why integration? ## The whole is more than the sum of parts .center[  ] --- # Why integration? ## We May lose important information .center[  ] --- # Why integration? ## Don't forget the Omics Cascade .center[  ] --- # From single to multi-omics ## Integromics entered the game (_We want it all_) .center[  ] --- # Can we get more data? ## From MultiOmics to Personalized Medicine .center[  ] Google "multi-omics for personalized medicine" images to see more ... --- # Data-Centric Projects have become key - The need to have multimodal data, including omics data, images, and clinical data
 has driven a multitude of __Research Projects__
 - Their first or ultimate objective is to _facilitate the path to personalized medicine_ through: .pull-left[ - data integration - data sharing, - data exchange (OMOP, HL7) - data FAIRification, - cloud computing and - (federated) data analysis,
 among others. ] .pull-right[  ]
 - This represents an _unprecedented opportunity_. - But requires the right people and knowledge. --- class: inverse, middle, center name: IODA # Integrative Omics Data Analysis --- # The goal(s) of Integrative Omics - The idea that efficient integration of data from different OMICS can facilitate the discovery of true causes and states of disease has pervaded the biomedical community. - The general gol of integrative analysis is the _deciphering of complex biological relationships (CBP)_ empowered by the _combined use of distinct pieces of information_ that represent a, probably partial, view of the _different levels at which these processes happen_. - More specifically integrative omics data anlysis is applied for - Disease subtyping, - Disease insights, - Biomarker development, - Combination with non-omics --- # Methods of integrative analysis .center[  ] Subramanian et alt., 2020. _Multi-omics Data Integration, Interpretation, and Its Application_ --- # Many data repositories .center[  Subramanian et alt., 2020. _Multi-omics Data Integration, Interpretation, and Its Application_ ] --- # Many data visualization portals .center[  Subramanian et alt., 2020. _Multi-omics Data Integration, Interpretation, and Its Application_ ] --- # So what? - We willl restrict to arbitrarily chosen situations: - Multivariate statistical methods, classic and extensions - for which we will sketch, - General ideas - Use case - and provide some examples of use. - See workshop --- # General framework: Matrix factorization - Matrix factorizations have become very popular in fields such as machine learning, recommender systems or deep learniong. .center[  ] _"Many key ideas of linear algebra, when you look at them closely, are really factorizations of a matrix, where the original matrix becomes the product of 2 or 3 special matrices."_
 Gilbert Strang. --- # Omics technolgies yield data matrices .center[  ] --- # Visualizing omics matrices ### _Heatmaps_ provide a simple way to visualize omics matrices. #### Clustering of rows/columns used to highlight relation between features or samples .center[  ] --- # Matrices can be factored - Factorization helps discover the "true" biological dimension
 - by revealing hidden complex biological processes (CBPs) .center[  ] --- # The SVD ## The mother of all factorizations .center[  ] --- # The SVD ## SVD can be re-written as latent factors .center[  ] --- # Factorization helps interpretation .center[  ] --- # Factorization helps interpretation .center[  ] --- # Distinct factorizations, distinct views .center[  ] --- # When a single omics is not enough - Ideally matrix factorizations can provide dimension-reduced data visualizations that help detect distinct patterns in features or samples. - Sometimes the information in the data does not allow for this separation, but _extending the factorization to different omics that can be related differently with the latent factors can do the job_. - As could be expected there exist many ways to do multiple factorization. - Multiple Factor Analysis, - Regularized Generalized Canonical Correlation Analysis, - Multiple Coinertia Analysis, ... --- # Multiple factor Analysis ## Straightforward generalization of PCA .center[  ] --- # A Colon Cancer Example - A set of 121 tumors from the TCGA (Weinstein, Collisson, Mills, et al. 2013) colorectal cancer cohort is analyzed. - The tumors have been profiled for - gene expression using RNA-seq, - mutations using Exome-seq, and - copy number variations using genotyping arrays. - Although two tumors arise in the colon, they may have distinct molecular profiles, which is important for treatment decisions. - The subset of tumors used in this chapter belong to two distinct molecular subtypes CMS1, CMS3 --- # A Colon Cancer Example ## Single omics don't separate well .center[  ] --- # A Colon Cancer Example ## Joint omics factorization provides much better separation .center[  ] --- # Summary part I - Biological Processes are complex and they are "probably" better revealed using distinct sources of information. - While there are many approache for the integrative analysis there is no universal "IODA" method. - Many families of many types of methods available: Need to be related, classified, filtered, benchmarked. - In many situations biology must guide the analysis - All data are not equally informative and it is often the case that some omics dominate others. : "Gene expression and _what else_?" --- # The workshop - Details and examples of single and multi-omics analyses are provided in the workshop. - Access [https://github.com/alexsanchezpla/202107-GRBio-Integration-Workshop](https://github.com/alexsanchezpla/202107-GRBio-Integration-Workshop) for the workshop materials. - You can clone or download the repository (see previous GRBio workshops) - Run the `InstallPackages.R` script in your computer to be sure all packages can be installed - __Warning__ the materials will be updated. Be sure to refressh the repository tomorrow at 9:30 --- class: inverse, middle, center name: IODAProjects # Integration problems we work with --- # FOBI (Food-Biomarker Ontology) ### Pol Castellano, Alex Sánchez .font130[ - Heterogeneus nutritional data (semantic problem) -> **FoodOn** ] .font130[ - Difficult association of nutritional data with other types of data (semantic and quantitative problem) ] .font130[ - **Unclear relationships between foods and metabolites** ] .center[] --- # FOBI (Food-Biomarker Ontology) ### Pol Castellano, Alex Sánchez .font130[ - Create an ontology that clearly defines the many complex relationships between **diet derived metabolites** and **foods** in a consistent and homogeneous way ] .font130[ - Reuse previous existing terms to maintain a consistent and standardized nomenclature (OBOFoundry) - FoodOn - ChEBI ] .center2[] .font130[ - Propose a consistent starting point for nutrimetabolomic studies - Design - Validation ] --- # FOBI (Food-Biomarker Ontology) ### Pol Castellano, Alex Sánchez  https://github.com/pcastellanoescuder/FoodBiomarkerOntology
 .pull-left[ ## Metrics - 2 sub-ontologies - 1197 terms - 4 different properties - 13 food top-level classes - 11 biomarker top-level classes - More than 4700 relationships - Part of **OBOFoundry project** [http://purl.obolibrary.org/obo/fobi.owl](http://purl.obolibrary.org/obo/fobi.owl) - FOBI IDs are indexed into the [HMDB](https://hmdb.ca) (Human Metabolome Database) and [FooDB](https://foodb.ca) (Food Database) ] .pull-right[] --- # Insights in Multi-Group Data Analysis ### Carolina Millapan, Ferran R., Esteban V.
 .pull-left[ - Analysis of variables observed in a set of individuals that belong to dierent groups. - Monitoring metabolite levels in blood of patients in different healthy/disease conditions, - Measurements of heavy metals in soil samples from dierent ecological environments, - Studies of gene expression for individuals with dierent experimental conditions ] .pull-right[  ] --- # Insights in Multi-Group Data Analysis ### Carolina Millapan, Ferran R., Esteban V. ### Multigroup PCA - __Multigroup Principal Component Analysis__ - Aim: _maximization of the interdistances between the points of the different groups_. - __Multi-Group Dimension reduction__ - Aim: find an orthogonal set of vectors such that each vector v tends to avoid that the projections of the observations of a given group do not overlap the centroids of the projections of the observations of each of the remaining groups. --- # Data Integration with Annotations ### Ferran Briansó, Alex Sánchez  --- # Data Integration with Annotations ### Ferran Briansó, Alex Sánchez  --- # Data Integration with Annotations ### Ferran Briansó, Alex Sánchez  --- # The goProfiles Approach ## Pablo Flores, Jordi Ocaña, Miquel Salicrú i Álex Sánchez  --- class: inverse, middle, center name: DataSharing # Biomedical data integration
 and data sharing --- # Precision or Personalized Medicine - Two patients with the same disease can respond very differently to the same treatment. - Why? Mainly due to the different genomic characteristics of each one. - Precision or Personalized Medicine aims at helping physicians to select the treatments that are most likely to help patients based on their genetics. - PM is currently experiencing significant advances due to the appearance of new diagnostic and computer methods that provide an understanding of the molecular bases of the disease, particularly of the genomics. --- # Personalized Medicine at a Scale ## The need for a paradigm change - Until recently, PM has been associated with experimental therapies _far from daily clinical practice_ - But its central elements arae now much easier to reach: - Increasing availability of Genomic Data, fast and cheap to produce - Increasing computing power in-house or in the cloud (EOSC) - Possibility of accessing clinical data in anonymized possibly federated ways - Having the ability to __integrate__ genomic, clinical and other social, environmental and behavioral factors, will (should) lead to a transformation in the way in which decisions are made with direct effect on clinical practice and public health measures.    - The ultimate goal is a safer, more efficient, preventive, and predictive medicine. --- # How will this be done (in Spain) ## The IMPaCT program - In mid-September 2020, the Council of Ministers approved the call for granting grants for the __Precision Medicine Infrastructure associated with Science and Technology__ (__IMPaCT__) of the Strategic Action in Health 2017-2020. - This decision, which involved the granting of 25.8 million euros to the Carlos III Health Institute (ISCIII) - The programs included in IMPaCT are aligned with several areas that will be developed in the future national strategy: - Predictive medicine; - Genomic medicine and - Data science. --- # The Predictive Medicine Program .pull-left[ - Aimed at the design and implementation of _a large population cohort with clinical, epidemiological and biological data, measured at the individual level_, - which allows representing the entire population residing in Spain, - including the ethnic variability and geographic and environmental diversity. - __Data sharing__ is an essential aspect: clinical data needs to be accessible for this program to be possible.  ] .pull-right[  ] --- # The Genomic Medicine Program .pull-left[ - It will develop _coordination infrastructures and protocols_ to carry out genomic analyzes and other 'omic' data in an effective, efficient and equitable accessible manner. - It will take as support large research centers that already have of state-of-the-art sequencing technology and experience in its application to the diagnosis of human diseases. - It will optimize and reinforce the available massive sequencing capacities, orienting them to the needs of genetic diagnosis -exomes, complete genomes, etc.- ] .pull-right[  ] --- # The Data Science Program - _Develop a system for the collection, integration and analysis of clinical and molecular data__ aimed at improving the health of each individual patient, and - Which allows the secondary use of existing information in the SNS to the benefit of society with the objectives of public health, health planning and research. - Its objective is to __optimize the management of the information generated__, in order to apply it in the most effective way for the population and the SNS. - It will provide - _bioinformatics tools_ for the management of genomic data and - _medical informatics_ solutions for the _management_ and _integration_ of clinical data, facilitating the interoperability of the clinical information systems of the different autonomous health systems. --- # IMPaCT Global View .center[  ] --- # New Skills:
 ## data sharing, ## data exchange (OMOP, HL7) ## data FAIRification, ## cloud computing, ## open science, ## reproducibility, ## (federated) data analysis, ## and, of course AI and ML --- class: inverse, middle, center name: DataProjects # Data Projects we work in @VHIR --- # Data Science Projects Platform @VHIR - The increasing needs in Data related projects leads to new structures to manage this. .center[  ] --- # External Data Projects: EOSC-Life .center[  ] --- # External Data Projects: EU-PEARL .center[  ] --- # External Data Projects: VEIS .center[  ] --- # Other External Data Projects - The European Health Data Space (TEHDAS) - EHDEN (European HEalth Data and EVidence Network) - DARWIN (Data Analysis and Real World Interrogation Network) All these projects - Are huge (all over Europe). - Aim at some form of data re-use for health related research. - Require different types od (trans-national) data sharing. - With common or similar technical and legal issues to be addressed --- class: inverse, middle, center name: Estrategia # Looking ahead - The analysis of Omics Data is an example of fruitful development between Statistics and Biological (Health) Sciences. - As more data is becoming available some therapeutical possibilities approach reality. - While Statistics will always be relevant to guide this approach other skills become important. - We must, at least, be aware of these skills and the problems they address because this is really an unprecedent opportunity. --- # Acknowledgements .center[  ]


A TCP connection to a client device for providing direct market access.
More...
#include <connection.hpp>
|
|
typedef std::shared_ptr< Connection > | Pointer |
| | a shared pointer type for this connection object
|
| |
A TCP connection to a client device for providing direct market access.
◆ create()
Create a shared pointer to a new connection.
- Parameters
-
| context | the IO context to create the connection with |
| authorizer | the authorizer for credential / account management |
| book | the limit order book for the instrument |
- Returns
- a shared pointer to the new connection
◆ get_output_buffer_size()
| uint32_t OrderEntry::Connection::get_output_buffer_size |
( |
| ) |
const |
|
inline |
Return the size of the output buffer (number of queued messages).
- Returns
- the number of messages in the outbound queue
◆ get_sequence()
Return the sequence number at this sender.
- Returns
- the sequence number of the next message to send
◆ get_socket()
| tcp::socket& OrderEntry::Connection::get_socket |
( |
| ) |
|
|
inline |
Return the socket this connection is using.
- Returns
- the socket this connection is using
◆ is_logged_in()
| bool OrderEntry::Connection::is_logged_in |
( |
| ) |
const |
|
inline |
Return true if the connection is authorized, false otherwise.
- Returns
- true if the connection has been authorized (logged in)
◆ trade()
Send a trade message to the client.
- Parameters
-
| order_id | the ID of the trade that occurred |
| price | the price the trade occurred at |
| size | the size of the trade the occurred |
| leaves_size | the size left on the order after the trade |
| side | the side of the book the trade is for |
The documentation for this class was generated from the following file:


|
|
Secretary: Grant Nagrant
<EMAIL_ADDRESS>248-701-0200
Oh hello there! I'm Grant! I will be your Underwater Hockey Secretary for this 2014-15 school year! Currently, I am a junior here at MSU majoring in Biomedical Laboratory Sciences. So while I spend a lot of time in labs and doing chemistry, they unfortunately don't allow me to wear a speedo in that setting and that's where UWH comes in! There are tons of awesome people on the team and we have so much fun together, I can't wait to share these good times with all you future rookies! Now get your butt to IM Circle to try it out and I will see you in the pool!
|


| Edition 2019-20 Edition 2020-21 |
A multi-armed bandit algorithm learns a game, just by observing the payoffs of its own actions. It is not “interest in” the game matrix, opponent's behaviour and other game specific attributes. A MAB learner is also not interested in teaching (i.e., influencing) other players. Important MAB algorithms are ε-Greedy learning, Q-learning, UCB learning, Thompson sampling, and Exp3.
Presented byLecturer. |
SlidesMay 4, 2021. |
ScreencastYoutube |
AssignmentNot this year. |


MUMSched v1.0
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BY
Poseidon Team


Northern Indiana’s 50-year-old Amish Acres to close Jan. 1
NAPPANEE, Ind. (AP) - An official says northern Indiana tourist destination Amish Acres will close at the end of the year after 50 years in business.
Executive Director Jeff Kitson of the Nappanee Area Chamber of Commerce said Friday he received a letter from founder and CEO Richard Pletcher saying his family is retiring at the end of 2019 and will close Amish Acres after its New Year’s fireworks show.
Kitson says the business will likely go to auction in early spring if the family hasn’t found a buyer by then.
TOP STORIES
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The Nappanee site includes a bakery, meat and cheese shop, arts and crafts boutiques, a theater for stage plays, an inn with 62 guest rooms and a restaurant featuring traditional Amish cooking. Kitson says more than 5 million people have visited.
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Please read our comment policy before commenting.


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{% extends "base.html" %} {% load djblets_deco djblets_extensions djblets_utils i18n %} {% block title %}{% trans "Authentication Error" %}{% endblock %} {% block content %}
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Please try logging in again. If the problem persists, please contact the maintainers and/or file a bug.


Hello! I am Sowmya! A creative Web Designer! HTML5,CSS,Javascript,Jquery,Boostrap has treated me well! Wink!
The following are the skills that excite me everyday:
<EMAIL_ADDRESS>@sowmyas


Plot a math function:
f(x)=
Function is invalid
{{ fnInvalid }}
Hide/Show settings ( {{showSettings}} )
Settings
Line width:
Minx
Maxx
Miny
Maxy
Notes:
Uses AngularJs to get immediate effect on changes
Uses Math.js to parse expression and calculate points
Uses flexboxes and vh for dimensionning canvas
complex are allowed: try "exp(i*x) + exp(-i*x)" ... Thanks to Math.js
TODO list as a reminder:
Store last changes of UI in cookies (my generic UI object)
Resize canvas or app (UI object)
Color picker
line width with cursor


Apasati aici
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{%extends "base.html"%}
{%block title%}Community{%endblock%}
{%block body%}
Engage intellect and ideas with the VC3
community on our Twitter account. A weekly developers
meeting takes place via Zoom video conference, in order to discuss
the state of affairs. Traditional high performance and high throughput
computing facilities largely assume local, centralized configuration and
arbitration of resources. While this model has been adequate for serving
individuals for some time, it has never been satisfactory for collaborating
groups that cross organizational boundaries: a computing facility designed
to meet the needs of one user community rarely meets the needs of others.
The result is that users retreat to private resources, resulting in
excess hardware acquisition, underutilized machines, or both. This is
especially unfortunate when the distinction between facilities lies more
in operating system and software configuration than fundamental
hardware differences. The virtual clusters for community computation (VC3)
project aims to make research computing facilities more
accessible to use by the broader user communities. In the VC3 paradigm,
the end user "allocates" a virtual cluster (VC) from existing facilities by
requesting, for example, 200 nodes of 24 cores and 64GB RAM each, with
100TB local scratch and 10Gb connectivity to external data sources. Once
allocated, the owner of the virtual cluster installs the required software,
transfers input data, and executes jobs. The users can share computing
resources with collaborators using the VC.
We do not intend to change the resource management systems or infrastructure
of existing facilities. Rather, VCs will be provisioned on
top of existing facilities by deploying user-level tools
(e.g. HTCondor-based tools for resource management, data caching,
and Parrot for virtual file system access) within the existing
batch systems. In short, a VC will appear as a large parallel
job managed by the end user to the facility administrators . Virtual clusters by themselves are not
enough: workloads must be self-configuring so that they can bring necessary
dependencies, discover the dynamic configuration, and adapt to the
(possibly) changing conditions of the virtual cluster. To accomplish
this integration, we will leverage a variety of
existing open-source tools and production-tested services. The end
product will be a flexible, optimizable software ecosystem with a generic
set of capabilities, presented to users as a computing resources
aggregation service accessible via a web portal. We presume the cluster
as an optimal abstraction as it naturally covers a large swath of modern
scientific computation and training base of expertise (e.g. campus
HPC centers). Our principal drivers are computating requirements in high-energy
physics, and in particular analysis workflows requiring
using multi-petabyte scale datasets from the ATLAS
and CMS experiments at the Large Hadron Collider (LHC) at CERN in
Geneva, Switzerland. The effectiveness of these deliverables will
be demonstrated at scale with CMS and ATLAS user applications and the
adoption of the VC3-implemented virtual clusters by new communities.About VC3
The cluster, re-imagined
Smarter workloads
Deliverables
The deliverables for this project will include:
A reference virtual cluster platform service
which describes the layered architectural components and the relationships
and connections between them;
A number of production service instances,
which providing a core computational feature set, to be used to coordinate grid,
commercial cloud, HPC center, and importantly, university campus cluster
access;
A selection of workflow tools and services
that function in the dynamically-configured
environment of a virtual cluster.


Money Play. How should Red play 21?
pips Red=117 White=119
(CorrectAnswer= 0/0, ErrorScore= 0)
Red could play safe with 5/2 as happened over the board.
However, White’s position will improve and all of Red’s outer board points are stripped. Despite the apparent risk now is the time for Red to hit with 18/17*, 18/16 and it’s not even close.
If White fans, which happens 25% of the time, then White must drop Red’s double. If White does hit there will be lots of return hits for Red. Any play that doesn’t hit is a triple blunder or worse.
However, White’s position will improve and all of Red’s outer board points are stripped. Despite the apparent risk now is the time for Red to hit with 18/17*, 18/16 and it’s not even close.
If White fans, which happens 25% of the time, then White must drop Red’s double. If White does hit there will be lots of return hits for Red. Any play that doesn’t hit is a triple blunder or worse.
1. Cubeful 2-ply 18/17*/15 Eq.: +0.531 0.654 0.165 0.007 - 0.346 0.125 0.004 2. Cubeful 2-ply 18/17* 18/16 Eq.: +0.490 (-0.042) 0.647 0.172 0.007 - 0.353 0.137 0.004 3. Cubeful 2-ply 18/17* 5/3 Eq.: +0.437 (-0.094) 0.622 0.178 0.008 - 0.378 0.149 0.005 4. Cubeful 0-ply 5/2 Eq.: +0.293 (-0.238) 0.589 0.103 0.001 - 0.411 0.064 0.000 5. Cubeful 0-ply 18/17* 13/11 Eq.: +0.255 (-0.276) 0.599 0.164 0.005 - 0.401 0.189 0.016


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| 6 Sep 1888 |
Joseph P. Kennedy born, Boston MA. |
| 22 Jul 1890 |
Rose Fitzgerald born, Boston MA. |
| Jun 1912 |
Graduates Harvard University. |
| 7 Oct 1914 |
Marries the daughter of Boston's mayor, Rose Fitzgerald. |
| Jul 1915 |
First son Joseph Patrick Kennedy Jr. born. |
| 1917 |
Assistant manager, Bethlehem Shipbuilding Corporation. |
| 29 May 1917 |
Son John F. Kennedy born, Brookline MA. |
| Sep 1918 |
Retarded daughter Rosemary born, Boston MA. |
| 1920 |
Daughter Kathleen born, Boston MA. |
| 10 Jul 1921 |
Daughter Eunice Mary born, Boston MA. |
| 6 May 1924 |
Daughter Patricia born, Boston MA. |
| 20 Nov 1924 |
Son Robert F. Kennedy born, Boston MA. |
| Feb 1928 |
Daughter Jean Anne born, Boston MA. |
| 1930 |
Assisted presidential campaign of Franklin D. Roosevelt. |
| 22 Feb 1932 |
Son, Edward Moore born, Brookline MA. Nickname Teddy. |
| 1934 |
Appointed chairman, Securities and Exchange Commission. |
| 1938 |
Appointed ambassador to Britain. Kennedy favored the appeasement of Adolf Hitler. |
| 1940 |
Resigns ambassadorship. |
| 1941 |
Has daughter Rosemary lobotomized. |
| 12 Aug 1944 |
Son Joe killed during World War II. |
| 14 May 1948 |
Daughter Kathleen killed in plane crash in France. |
| 23 May 1953 |
Daughter Eunice marries Robert Sargent Shriver, Jr., New York City. |
| 19 Dec 1961 |
Suffers stroke. |
| 22 Nov 1963 |
Son John F. Kennedy assassinated, Dallas TX. |
| 6 Jun 1968 |
Son Robert F. Kennedy assassinated, Los Angeles CA. Buried in Arlington National Cemetery. |
| 1968 |
Daughter Eunice Kennedy Shriver founds the Special Olympics. (First competition July 20.) |
| 18 Nov 1969 |
Joseph P. Kennedy dies, Hyannisport, MA. He is buried in Holyhood Cemetery, Brookline, MA. |
| 22 Jan 1995 |
Wife Rose Fitzgerald Kennedy dies at the age of 104. Buried next to her husband. |


|
OpenJij C++ interface
0.2.0
|
ClassicalIsingPolynomial structure. More...
#include <classical_ising_polynomial.hpp>
Public Types | |
| using | Interactions = std::unordered_map< std::vector< graph::Index >, FloatType, utility::VectorHash > |
| Interaction type, which is the same as the one defined in graph/polynomial.hpp. More... | |
| using | system_type = classical_system |
| system type More... | |
Public Member Functions | |
| ClassicalIsingPolynomial (const graph::Spins &init_spins, const graph::Polynomial< FloatType > &init_interaction) | |
| Constructor of ClassicalIsingPolynomial. More... | |
| graph::Index | get_max_variable () const |
| Return "max_variable_". More... | |
| void | check_variables () |
| Check if spin/binary configurations are valid for "vartype". More... | |
| int | Sign (graph::Binary binary) |
| Return -1 or +1 in accordance with the input binary. More... | |
| int | zero_or_one (graph::Binary binary, std::size_t zero_count) |
| Return 0 or 1 in accordance with the input binary and zero_count. More... | |
| int | zero_or_one (graph::Binary binary1, graph::Binary binary2, std::size_t zero_count) |
| Return 0 or 1 in accordance with the input binaries and zero_count. More... | |
| void | set_update_matrix (std::vector< std::vector< graph::Index >> &interacted_spins) |
| Set "crs_row", "crs_col", "crs_val", and "crs_sign_p" (spin variable cases) or "crs_zero_count_p" (binary variable cases). More... | |
| const cimod::Vartype & | get_vartype () const |
| Return vartype. More... | |
| void | update_zero_count_and_binary (const std::size_t index) |
| Update "zero_count_" and "spin". This function is used only when" vartype" is cimod::Vartype::BINARY. More... | |
| void | update_sign_and_spin (const std::size_t index) |
| Update "sign_" and "spin". This function is used only when" vartype" is cimod::Vartype::SPIN. More... | |
| void | update_dE_for_spin (std::size_t index) |
| void | update_dE_for_binary (std::size_t index) |
| void | reset_spins (const graph::Spins &init_spins) |
| const std::vector< FloatType > & | get_J_term () const |
| Return the interactions stored in "J_term_". More... | |
| const std::vector< std::vector< graph::Index > > & | get_interacted_spins () const |
| Return the interactes spins/binaries stored in "interacted_spins_". More... | |
| const std::vector< std::vector< graph::Index > > & | get_connected_J_term_index () const |
| Return "connected_J_term_index_". More... | |
| FloatType | get_max_dE () const |
| Return "max_dE". More... | |
| FloatType | get_min_dE () const |
| Return "min_dE". More... | |
Public Attributes | |
| const graph::Index | num_spins |
| The number of spins/binaries. More... | |
| graph::Spins | spin |
| Spin/binary configurations. More... | |
| const cimod::Vartype | vartype |
| The model's type. cimod::vartype::SPIN or cimod::vartype::BINARY. More... | |
| std::vector< FloatType > | dE |
| Store the information about the energy difference when flipping a spin/binary. More... | |
| std::vector< std::size_t > | crs_row |
| Row of a sparse matrix (Compressed Row Storage) to update "dE". More... | |
| std::vector< graph::Index > | crs_col |
| Column of a sparse matrix (Compressed Row Storage) to update "dE". More... | |
| std::vector< FloatType > | crs_val |
| Value of a sparse matrix (Compressed Row Storage) to update "dE". More... | |
| std::vector< int8_t * > | crs_sign_p |
| Value of a sparse matrix (Compressed Row Storage) to update "dE". More... | |
| std::vector< uint64_t * > | crs_zero_count_p |
| Value of a sparse matrix (Compressed Row Storage) to update "dE". More... | |
Private Member Functions | |
| void | set_max_variable (const Interactions &interaction) |
| Set "max_variable_". If an interaction is zero, corresponding variable is ignored. More... | |
| void | set_interacted_spins (const Interactions &interaction) |
| Set "interacted_spins_". More... | |
| void | set_J_term (Interactions &interaction) |
| Set "connected_J_term_index" and "J_term_". If "vartype" is cimod::SPIN, "sign_" is also set, else If "vartype" is cimod::BINARY, "zero_count_binary_" is also set. More... | |
| Interactions | relabel_interactions (Interactions &input_interactions) |
| Relabel interactions. More... | |
| void | reset_dE () |
| Set delta E (dE), which is used to determine whether to flip the spin/binary or not. More... | |
Private Attributes | |
| FloatType | max_dE |
| The maximal energy difference between any two neighboring solutions. More... | |
| FloatType | min_dE |
| The minimal energy difference between any two neighboring solutions. More... | |
| std::vector< std::vector< graph::Index > > | interacted_spins_ |
| Stores the set of spins/binaries corresponding to the interactions. More... | |
| std::vector< FloatType > | J_term_ |
| Store the values of the interactions. More... | |
| std::vector< std::vector< std::size_t > > | connected_J_term_index_ |
| Store the information about the indices of "J_term_". More... | |
| std::vector< int8_t > | sign_ |
| Store the information about the sign of variables. More... | |
| std::vector< uint64_t > | zero_count_ |
| Store the information about the number of variables takeing zero. More... | |
| graph::Index | max_variable_ = 0 |
| The max variable (the max index of spin/binary configulations) More... | |
ClassicalIsingPolynomial structure.
| using openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::Interactions = std::unordered_map<std::vector<graph::Index>, FloatType, utility::VectorHash> |
Interaction type, which is the same as the one defined in graph/polynomial.hpp.
| using openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::system_type = classical_system |
system type
|
inline |
Constructor of ClassicalIsingPolynomial.
| init_spins | graph::Spins&. The initial spin/binary configurations. |
| init_interaction | graph::Polynomial<FloatType>& (Polynomial graph class). The initial interacrtions. |
|
inline |
Check if spin/binary configurations are valid for "vartype".
|
inline |
Return "connected_J_term_index_".
|
inline |
Return the interactes spins/binaries stored in "interacted_spins_".
|
inline |
Return the interactions stored in "J_term_".
|
inline |
Return "max_dE".
|
inline |
Return "max_variable_".
|
inline |
Return "min_dE".
|
inline |
Return vartype.
|
inlineprivate |
Relabel interactions.
For example, if the interaction is only J[2,3,7] = -1.0 for 3 sites system, this function relabel the interaction as J[0,1,2] = -1.0
| input_interactions | Interactions& |
|
inlineprivate |
Set delta E (dE), which is used to determine whether to flip the spin/binary or not.
|
inline |
|
inlineprivate |
Set "interacted_spins_".
|
inlineprivate |
Set "connected_J_term_index" and "J_term_". If "vartype" is cimod::SPIN, "sign_" is also set, else If "vartype" is cimod::BINARY, "zero_count_binary_" is also set.
| interaction | Interactions& |
|
inlineprivate |
Set "max_variable_". If an interaction is zero, corresponding variable is ignored.
| interaction | const Interactions& |
|
inline |
Set "crs_row", "crs_col", "crs_val", and "crs_sign_p" (spin variable cases) or "crs_zero_count_p" (binary variable cases).
These std::vector constitute a sparse matrix (Compressed Row Storage), which is used to update "dE".
| interacted_spins | std::vector<std::vector<graph::Index>>& |
|
inline |
Return -1 or +1 in accordance with the input binary.
| binary | graph::Binary |
|
inline |
|
inline |
|
inline |
Update "sign_" and "spin". This function is used only when" vartype" is cimod::Vartype::SPIN.
| index | const std::size_t |
|
inline |
Update "zero_count_" and "spin". This function is used only when" vartype" is cimod::Vartype::BINARY.
| index | const std::size_t |
|
inline |
Return 0 or 1 in accordance with the input binary and zero_count.
| binary | graph::Binary |
| zero_count | std::size_t |
|
inline |
Return 0 or 1 in accordance with the input binaries and zero_count.
| binary1 | graph::Binary |
| binary2 | graph::Binary |
| zero_count | std::size_t |
|
private |
Store the information about the indices of "J_term_".
| std::vector<graph::Index> openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::crs_col |
Column of a sparse matrix (Compressed Row Storage) to update "dE".
| std::vector<std::size_t> openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::crs_row |
Row of a sparse matrix (Compressed Row Storage) to update "dE".
| std::vector<int8_t*> openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::crs_sign_p |
Value of a sparse matrix (Compressed Row Storage) to update "dE".
Note that this is used only for binary variable cases. This stores the pointers for "sign_", which stores the information about the sign of variables.
| std::vector<FloatType> openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::crs_val |
Value of a sparse matrix (Compressed Row Storage) to update "dE".
| std::vector<uint64_t*> openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::crs_zero_count_p |
Value of a sparse matrix (Compressed Row Storage) to update "dE".
Note that this is used only for binary variable cases. This stores the pointers for "zero_count_", which stores the information about the number of variables takeing zero.
| std::vector<FloatType> openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::dE |
Store the information about the energy difference when flipping a spin/binary.
|
private |
Stores the set of spins/binaries corresponding to the interactions.
The keys of "Interactions" (std::unordered_map<std::vector<graph::Index>, FloatType, utility::VectorHash>)
|
private |
Store the values of the interactions.
The values of "Interactions" (std::unordered_map<std::vector<graph::Index>, FloatType, utility::VectorHash>)
|
private |
The maximal energy difference between any two neighboring solutions.
|
private |
The max variable (the max index of spin/binary configulations)
|
private |
The minimal energy difference between any two neighboring solutions.
| const graph::Index openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::num_spins |
The number of spins/binaries.
|
private |
Store the information about the sign of variables.
Note that this is used only for spin variable cases, and the pointers of this std::vector is stored in "crs_sign_p". Do not change this std::vector.
| graph::Spins openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::spin |
Spin/binary configurations.
| const cimod::Vartype openjij::system::ClassicalIsingPolynomial< graph::Polynomial< FloatType > >::vartype |
The model's type. cimod::vartype::SPIN or cimod::vartype::BINARY.
|
private |
Store the information about the number of variables takeing zero.
Note that this is used only for binary variable cases, and the pointers of this std::vector is stored in "crs_zero_count_p". Do not change this std::vector.


#BlackoutForBrexit
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{% extends "account/email/base.html" %}
{% set unsubscribe = True %}
{% block body %}
Hello {{ project.owner.name }}
Here are some updates about how your project has been running over the past week.
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Debugger
EditFlixel comes with a fairly powerful debugging overlay. You can open it with one of the two default toggle keys (` and \ with a QWERTY keyboard layout). Note that these are configurable via FlxG.debugger.toggleKeys
. Alternatively, you can do the same in code via the FlxG.debugger.visible
flag.
Note that the debugger does not exist when compiling with FLX_NO_DEBUG
. With the default Project.xml
, this is the case in release mode.
Debug draw
FlxG.debugger.drawDebug
can be enabled to display the hitboxes of every FlxObject
added to the state (alternatively, press the cube button in the upper right corner of the debugger).
The hitboxes are color-coded based on the collision properties. For FlxObject
and FlxSprite
this means:
- Blue for
allowCollisions == FlxObject.NONE
- Green for
immovable
objects - Red otherwise
The color is customizable via the debugBoundingBoxColor
property.
The behavior of tiles in FlxTilemap
is slightly different:
- Blue for
allowCollisions == FlxObject.NONE
- Green for
allowCollisions == FlxObject.ANY
- Pink for other values of
allowCollisions
The Log Window
The log window is used to display traces and can be accessed via FlxG.log
. You can also redirect any trace()
-calls to it with FlxG.log.redirectTraces = true;
. Using it is mostly a matter of preference, some people prefer to have their traces displayed in their IDE of choice (FlashDevelop's output panel for example).
Some flixel-internal errors will also be output to the log window.
Log styles
It's possible to customize things like text color, size, style or add a prefix by using log styles. FlxG.log.warn()
, error()
and notice()
use pre-defined log styles.
Here's an example of how you could differentiate each trace by the player from others by adding a [Player]
prefix and printing it in green:
var playerAction = new LogStyle("[Player]", "00FF40");
FlxG.log.advanced(" Shoot", playerAction);
The Watch Window
It's very common to use trace()
-calls to output the value of certain variables for debugging. However, this approach doesn't scale very well - at 60 fps, tracing the values of multiple variables results in a flood of messages. Breakpoints-debugging is great to inspect a game's internal state, but doesn't help when interrupting the execution is not an option, for example when debugging input logic.
This is where the watch window comes into play. It displays the values of variables using reflection. For example, to keep track of the player's position:
FlxG.watch.add(_player, "x");
FlxG.watch.add(_player, "y");
The display string does not have to be the same as the variable's name, "numEnemies" is much more descriptive than "length" in this example:
FlxG.watch.add(_enemies, "length", "numEnemies");
For static variables, you pass the class instead of an object:
FlxG.watch.add(FlxG, "height");
It's also possible to edit the displayed values by clicking on them, entering a new value in the text field and pressing enter to confirm. This even works with FlxPoint
objects.
To remove a watch entry again, simply call FlxG.watch.remove(object, variableName)
.
Quick watches
Quick watches are a lightweight alternative to a regular watch entry. They don't require a variable, they simply store a value for a String
name. The following example stores the result of FlxG.keys.anyPressed(["UP", "W"])
under the name "Up key pressed"
- this is updated every frame since it happens in update()
.
override public function update():Void
{
super.update();
FlxG.watch.addQuick("Up key pressed", FlxG.keys.anyPressed(["UP", "W"]));
}
To remove a quick watch entry, call FlxG.watch.removeQuick(name)
.
Quick watch values can not be modified.
Mouse watch
FlxG.watch.addMouse()
is a convenient helper to display the current mouse position in the watch window. This can be useful to find the right coordinates to position UI elements at. You can also use the console command watchMouse
(short: wm
) to call this function.
The Stats Window
The stats window displays some basic profiling info:
- FPS value
- Memory usage in MB
- The amount of
update()
calls this frame (and the time it took in ms) - The amount of
draw()
calls this frame (and the time it took in ms) - The size of the
FlxQuadtree
pool for collision detection - The size of the
FlxList
(used for quad trees) pool
3 and 4 are especially useful when it comes to performance optimization ("Do I need to optimize my rendering or my update-logic?"). Of course this is only very basic data, profiling tools like Adobe Scout or hxScout provide much more detailed information.
The Bitmap Log Window
The Bitmap Log can be used to display BitmapData
objects via FlxG.bitmapLog.add(bitmapData)
. This can be useful to debug logic that manipulates some BitmapData
. The window provides a slideshow to scroll through logged bitmaps. You can use the middle mouse button to move the graphic around and the mouse wheel to zoom in and out.
You can also inspect flixel's internal BitmapData
cache by calling FlxG.bitmapLog.viewCache()
or entering the console command viewCache
(short: vc
).
The Console Window
The console allows you to set the values of variables or call functions at runtime (where you would otherwise have to recompile the game) and many other things.
By default, the game is paused when the console text field receives focus. After a command is executed, the game progresses one frame so the effects can be seen.
The console stores executed commands (use the up and down keys to cycle through them). This history is persistent across executions of your game (but not across different target platforms).
The help
command already provides a short documentation on available commands, for some however it's worth going into a little more detail.
The set
command
set
(short: s
) sets the value of an arbitrary variable using Reflect.setProperty()
.
Let's take a look at an example that works in the Mode demo:
set FlxG.state._player.x 50
If the command was successful, the player x position should now be 50 and the log window says > set: Player.x is now 50
.
The first argument is the path to the variable. The "starting point" of the dot-path needs to be registered for the console to be able to resolve the variable. FlxG
is automatically registered to the console beforehand by Flixel.
The same is true for the current FlxG.state
instance. This allows us to shorten the command:
set state._player.x 50
To register objects (to access member variables) or classes (to access static variables), you can call FlxG.console.registerObject()
:
// Inside the Player constructor
FlxG.console.registerObject("player", this);
With that, the previous command can be shortened even further to just set player.x 50
.
The call
command
call
(short: c
) is the counterpart to set
for calling functions (using Reflect.callMethod()
under the hood). We can use this to make the player in Mode jump:
call state._player.jump
Upon succesful execution, > call: Called 'state._player.jump()'
should be output to the log window.
We can shorten the previous command by registering an alias for jump()
with FlxG.console.registerFunction()
. The following makes the command call jump
possible:
// Inside the Player constructor
FlxG.console.registerFunction("jump", jump);
It's also possible to call functions with arguments:
call FlxG.camera.shake 0.05 5
The fields
command
fields
(short: f
) lists all fields (variables, properties and fuctions) of a given object, for example
fields state._player
Note that this is equivalent to fields state._player 0
and doesn't include any fields of parent classes like FlxSprite
. The second argument specifies how many parent classes should be included. With 3
, it would go all the way down to FlxBasic
, since the inheritance hierarchy looks like this: Player
> FlxSprite
> FlxObject
> FlxBasic
.
Addings custom commands
Custom console commands can be registered with FlxG.console.addCommand()
. In principle, a custom command is just a function, so this is similar to what you can already do with the call
command. However, doing it this way there's no need to prefix the command with call
. There are also a few more options, like the ability to add some documentation for the help
command.
Here's an example command spawnEnemy
, spawning a new enemy at the current mouse position.
// in PlayState#create()
FlxG.console.addCommand(["spawnEnemy", "se"], function() {
var mousePos = FlxG.mouse.getWorldPosition();
var enemy = _enemies.recycle(Enemy);
enemy.init(Std.int(mousePos.x), Std.int(mousePos.y), _enemyBullets, _bigGibs, _player);
});
Tracker Windows
Tracker windows are a convenient way to inspect the most important properties of a class / object. Each tracker window is basically a watch window instance. It's the only window type that can be closed.
A tracker profile defines the properties that should be watched for a specific class. Let's take a look at the pre-defined tracker profile for FlxSprite
:
new TrackerProfile(FlxSprite, ["frameWidth", "frameHeight", "alpha", "origin", "offset", "scale"], [FlxObject])
The first argument determines the class the profile belongs to, the second is an Array<String>
containing the property names. The third argument is a list of extensions - in this case just FlxObject
. This means that the properties defined in the tracker profile of FlxObject
will be added to tracker windows for FlxSprite
as well. This works recursively - FlxObject
"extends" the FlxBasic
tracker profile, so any properties of that profile will be added as well. This is why FlxG.debugger.track(_player)
in Mode's PlayState#create()
creates a window with a longer list of properties than you'd initially expect from the FlxSprite
profile:
Alternatively, you can use the console to create tracker windows at runtime:
track FlxG.state._player
The real power of tracker windows comes with the ability to define custom profiles, for example for the Player
class in Mode:
FlxG.debugger.addTrackerProfile(new TrackerProfile(Player, ["isReadyToJump", "_shootCounter", "_jumpPower"], [FlxBasic]));
(Note: calling addTrackerProfile()
causes a crash on the latest haxelib release due to a bug. As a workaround, you can call FlxG.debugger.track(null);
beforehand).
The VCR
Flixel's VCR feature (recording and replaying via FlxG.vcr
) is mostly disabled by default and can be activated with the FLX_RECORD
define. Even so, a few features are still available by default via the middle three buttons of the debugger:
The left button resets the current state via FlxG.resetState()
.
The middle button pauses / unpauses the game.
The right button pauses the game if it isn't already paused and skips ahead exactly one frame (one update()
and one draw()
call). This can be very useful for debugging certain issues.
If FLX_RECORD
is defined, two more buttons are available:
The circle starts a new recording - it also resets the current state, since the VCR does not support recordings that start mid-state. If a recording has already been started, the button stops it and opens a file dialog to save it.
The button with the folder icon right allows loading record files and replaying them.
Adding Debugger Buttons
You can add custom buttons to the debugger header using FlxG.debugger.addButton()
. This is what FlxNapeState
from flixel-addons does if you use it - it adds a convenient "N" button to toggle Nape's debug draw.
Debugger buttons are persistent across states - FlxG.debugger.removeButton()
has to be called manually to remove state-specific buttons.
Debugger Layouts
A debugger layout determines the initial position and size of each debugger window. The available layouts are described in the DebuggerLayout enum. You can change the current layout by calling FlxG.debugger.setLayout()
.
Here's an example of DebuggerLayout.RIGHT
:


DAVE A film review by Frank Maloney Copyright 1993 Frank Maloney
DAVE is a film directed by Ivan Reitman and written by Gary Ross. The cast includes Kevin Kline, Sigourney Weaver, Ben Kingsley, Frank Langella, Charles Grodin, and Ving Rhames. Rated PG-13 for language and sexual situations.
Trivial first things first: Kevin Kline does a nude scene; Sigourney Weaver does not. And a cute one it is. Secondly, some of you are going to be having a lot of fun spotting the many "as himself or herself" cameos by political and media celebrities. There's a pretty good list of them in the closing credits and when you go back for a second or third viewing, you'll get another chance to add to your Life Life.
And the chances are you will be going back. DAVE is a very watchable movie with a heart of gold, a popular and needed message, a gentle, affirming satire, and many engaging, even endearing performances.
There is Frank Langella as the corrupt and corrupting presidential chief of staff. Langella has developed the art of the villain to a fine point. Charles Grodin makes this his best performance in years as Dave's slightly bug-eyed, slightly long-suffering pushover pal and small businessman. Ben Kingsley is perhaps a shade too noble, a touch too wooden as the incorruptible vice-president. Ving Rhames as the head of the presidential security detail slowly unbends and opens up, turning into a really lovable guy who turns in a one-line, slightly oblique declaration of male friendship that in the context is rather sweet; otherwise, his is a nicely paced comic performance that depends on minimalist gestures and looks and is admirably, but subtly masterful.
Sigourney Weaver plays the First Lady, alienated from her husband for good reasons but hanging in there to do some good for her favorite cause. Weaver proves that she can be strong and likable and still have a very expensive haircut.
And finally, of the actors, we come to Kevin Kline, whose versatility and presence I've admired since A FISH CALLED WANDA (even though he was in several earlier films, I failed to pick up on him until then). Kline brings so much energy and enthusiasm and charm to his role of the ultimate impersonator. A question the film asks in its non-preaching way is who is greater impersonator, Dave or the President he steps in for. Kline is a perfectionist, a detail-oriented actor. In this dual role he has to look like two different men who just happen to have identical features. The way their different personalities inform and shape those features makes them recognizable to us and a kind of challenge that might be a nightmare for another actor.
The film benefits not only from having a first-rate cast but also Ivan Reitman as director and Gary Ross as writer. Reitman, who has directed GHOSTBUSTERS and TWINS, is at his best in his particular style of breezy gags, convincing production values, and a common-person's moral center. This is a worthy successor to the Capra tradition, a kind of KEVIN KLINE GOES TO WASHINGTON. Its vision and its ideals are simple and, I fear, simplistic, but they add up to a heart-warming fantasy about honesty and common-sense fixing the complex problems of the day. Maybe not, after all it's been a while since we tried honesty and commonsense. And along the way Ross has given us a lot of very funny gags, a story that offers surprises and few holes, and lots and lots of laughs.
I highly recommend DAVE to one and all, even at full prices.
-- Frank Richard Aloysius Jude Maloney .
The review above was posted to the
rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).
The Internet Movie Database accepts no responsibility for the contents of the
review and has no editorial control. Unless stated otherwise, the copyright
belongs to the author.
Please direct comments/criticisms of the review to relevant newsgroups.
Broken URLs inthe reviews are the responsibility of the author.
The formatting of the review is likely to differ from the original due
to ASCII to HTML conversion.
Related links: index of all rec.arts.movies.reviews reviews


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drawPixel
drawPixel(SDL_Surface *surface, int x, int y, unsigned int r, unsigned int g, unsigned int b): funcs.cc
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| Home | Trees | Indices | Help |
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distalgs.Algorithm --+ | distalgs.Synchronous_Algorithm --+ | SynchLubyMIS
A randomized algorithm that constructs a Maximal Independent Set
The algorithm works in stages, each consisting of three rounds.
Requires:
Effect:
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Inherited from Inherited from |
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Inherited from |
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Determines what messages a Process, p, will send.
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Determines what state transition a Process, p, will perform, having received messages, msgs
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I'm A Celebrity: Roman Kemp's impressions of Ant and Dec steal the show
The presenters' reaction was funnier still!
by Karen HylandRoman Kemp has revealed a secret talent for doing impressions... specifically of I'm A Celebrity hosts Ant and Dec.
The radio DJ showcased his skills during last night's show, much to the delight of his campmates.
First he took off Dec, then turned his attention to Ant, in a scenario where he was watching the celebs do a trial.
The son of crooner Martin had viewers in hysterics too.
Read more: Viewers praise teary Jac Jossa for nailing challenge
One wrote on Twitter: "Roman's impressions of Ant and Dec has to be the funniest moment of the series so far... outstanding!"
Another said: "@romankemp imitating ant and dec on @imacelebrity has to be the best thing yet!!"
And the compliments kept coming...
Even better was Ant and Dec's reaction to the contestant's mickey taking.
Apparently affronted, the lads then did an impression of HIM doing an impression of them.
Dec over-exaggerated his soft voice, while Ant was intentionally OTT.
Fans of the ITV show were tickled even more by this!
One summed it up perfectly: "@antanddec doing an impression of Roman Kemp doing an impression of Ant and Dec is the quality television I come here for #ImACeleb."
Read more: Roman and Adele in Jungle Jane spat
Are you impressed by Roman so far? Leave us a comment on our Facebook page @EntertainmentDailyFix and let us know what you think!


Constructor
new BIConditionalFormat(sourceID, targetID, val, op, colour, columnMap)
Parameters:
| Name | Type | Description |
|---|---|---|
sourceID
|
String |
Simplified column map ID for the column on which the formatting rule is based. |
targetID
|
String |
Simplified column map ID for the column on which the formatting style should be applied. |
val
|
string | number |
Value the rule has to match. |
op
|
string |
Operator ID for the formatting rule. Can be one of 'equal', 'notEqual', 'greater', 'greaterOrEqual', 'less', 'lessOrEqual' or 'heatmap'. |
colour
|
string |
Hex colour to apply if the formatting rule is matched. |
columnMap
|
Object |
Column Map objects have properties containing |
Members
Operator
Operator ID for the formatting rule. Can be one of 'equal', 'notEqual', 'greater', 'greaterOrEqual', 'less', 'lessOrEqual' or 'heatmap'.
SourceID
Simplified ID for the column on which to base the rule.
SourceName
Name of the column on which to base the rule.
Style
Style object defining all of the attributes to apply when the rule matches. Currently only supports the colour
property which requires a Hex value.
TargetID
Simplified ID for the column on which to apply styling if the rule is true.
TargetName
Name of the column on which to apply styling if the rule is true.
Value
Value the rule has to match.
Methods
compare(value) → {boolean}
Compares a given value against the rule and returns a boolean to indicate a match. Alternatively, a whole row of data can be passed and the correct column will be automatically identified.
Parameters:
| Name | Type | Description |
|---|---|---|
value
|
string | number | object |
Row of data or value to match against the conditional formatting rule. |
Returns:
Indicates whether the rule has matched or not.
- Type
- boolean
sourceIndex()
Returns the index of the source column if it is defined as a multiple.
sourceProperty()
Returns the property code of the source column. Strips the index away if it is defined as a multiple.
targetProperty()
Returns the property code of the target column. Strips the index away if it is defined as a multiple.


Well, it all started in February when my friend and I started using Diphenhydramine recreationally. We had heard that it makes you hallucinate and we had read experiences. We stopped using DXM temporarily to make room for DPH. The first time I took 25 tablets of Benadryl (625mg). The second I took only 22 tablets (550mg). The third I took 30 tablets (750mg), and this time, the fourth time, the last time, I took 30 again.
It was a week after spring break. I got home from my girlfriends house at about 11:20pm. I called my friend over and we slowly downed the little pink pills. We did this in my room since it had a lock and my parents are quite nosey. I took thirty, he took thirty-six. He weighs a bit more than me though so it was about even.
I started my stopwatch as soon as we downed the first set of ten. We had all the pills down as my stopwatch passed the six minute mark. We had also consumed two cokes each. As crazy as it may sound, a minute after I had all the pills down, I swear I started hallucinating. A hard-cover book appeared to be bending in the corner of my eye. I didn't tell this to my friend because he'd think I was retarded, which at times I am.
We went for a walk as my stopwatch approached ten minutes. We disposed all the boxes and wrappers by dumping them in my neighbor's trash can. We slowly walked back to my house. We both started shaking and shivering, as it was only March and still a bit chilly out. As we approached my house I noticed the downstairs lights were on. I yelled, 'Oh Shit!' and we started running towards the house. Surely my mother was downstairs. I told her we just went for a walk and we were fine. I told her to go back to bed. I noticed my voice was becoming extremely light and weak. It was on the verge of a whisper. Once she got back to bed, I was much relieved.
My friend and I started playing Medieval: Total War, the best game ever. I honestly don't remember it too well, but he says we did. I turned on some soft rock music on low on Winamp. I told him we should lay down until the shock of the DPH left. I actually just wanted to sleep. My voice had turned into a whisper by now, and my body felt like it weighed about 600lbs. We pulled the futon out from against the wall and extended it into a bed. We decided not to sleep longitudially on the bed, since we were both very straight. We slept laterally with our legs protruding a good two feet from the side of the bed. I grabbed a few blankets and threw them on us, and my friend used my beanbag as a footrest.
My state of mind was in a word: chaotic. Waves of opposing emotions overwhelmed my psychie: fatigue, apathy, paranoia, and feminism. I checked my stopwatch. An hour had passed since we consumed the pills. The lights were off so I didn't get to notice any open-eye hallucinations.
My stomach started to ache with a sharp, pulsating sensation. I noticed I could evade the pain by taking deep slow breaths. In my mind I thought I would puke if I stopped breathing slowly and deeply. I felt my heart in complete tachycardia. It was like a bass drum being beaten my an obiese boxer from southern Kentucky. Insane as that may sound, those were the exact words that came through my head.
I checked my watch again: six hours elapsed. That can't be right I thought. I checked it again: Hello. My watch was talking to me. It didn't strike me as a hallucination but simply as the way things were. No matter what time it was, I had to pee. I would've stayed and talked to the watch, but all that would've come out would be a whisper. And the effort it would've taken would force me into a coma. I slowly stood up. Now I no longer felt heavy. I felt like I was hovering. I had set my glasses by the computer.  I opened the door and hovered to the bathroom.
When I finally arived in my bathroom, I turned on the lights and began to piss. It kept coming out. It kinda stung, but I wasn't about to complain. I noticed that we now had a black fish in our toilet bowl. It swam aimlessly about inside the toilet. I tried pissing directly at it but it must've taken it the wrong way. It flipped out into the sink. I finished pissing and walked to the sink. It was so real. The fish was still in it, grasping for water. I turned on the faucet to let it breathe. After about ten seconds, it turned into a very small maple tree that got sucked down the drain. I thought my plumber is going to be pissed about this. I washed my hands and returned to my computer room.
I suppose somewhere in my head, I knew a black fish could not live a toilet, nor could it turn into a small maple and be swallowed by my sink. Perhaps it only happened because it was impossible. Perhaps my subconscious awareness of the bounds of reality provoked this visual manifestation. Whatever the cause, It freaked me out. I didn't realize it was a hallucination until I re-entered the computer room and took off my glasses and went back to sleep (well, I wasn't really sleeping, but thats what I'm calling it so sue me).
Throughout the night I continued making voyages to the bathroom and being confronted by open-eye-hallucinations such as ants and spiders swarming out of my vents, a gecko on the mirror, a threat note posted on the bathroom door. It was a strange feeling, having to pee constantly, but never being able to do so in peace.
My friend announced he was leaving. I looked at my watch. It was 10 in the morning. I said goodbye and walked upstairs. I had to go to a church trip to Des Moines at noon. I walked into the kitchen looking for food.  I was worried to say the least. I couldn't tell if I was still messed up or not.
We wound up sitting on a couch in my upstairs living room. My mother opened the conversation with, 'How much benadryl did you take last night?'  She hadn't asked me a thing, but I heard it. I heard the question I didn't want to hear and answered it.  I got scared. I looked at my watch again, 9:30.  I'm still hallucinating. It was just 10. I looked at the wall clock which has large numbers, hard to mistake.
Maybe my parents were never talking to me. Maybe I could go downstairs and sleep. I got up and made my way downstairs. I never made it. I wound up outside. My parents got me and started yelling at me. My mom forced my dad to take me to the hospital. I told them I was fine, but she insisted. To say the least, the ride to the hospital felt like years. Seriously, years. No exaggeration. It only took about 17 minutes in reality, but I was no longer in reality.
In the waiting room I asked for some water because the dry mouth was setting in. My dad got me an Aquafina. I drank a sip and choked on it. I couldn't swallow. I spit it back in the bottle and set it down. I told him I couldn't swallow. Suddenly I was back in my house. I was in my computer room. My mom came down and told me to get back to the hospital. Shit, I'm dreaming. I awoke and I was still at the hospital. I longed to get back to bed with my parent's ignorance, but I was lying back down on a hospital bed with needles in me and sensors all over my body. I saw many hallucinations at the hospital since it was well illuminated with fluorescent bulbs and great windows. At one point I thought I was in Davenport.
 It wasn't even that much fun. No it wasn't any fun.  I still hallucinate today although this was nine weeks ago. Just small things of course. I plan to pick up DXM again some time this summer. I never will do Diphenhydramine again. It sucked. Anyways, goodluck to all the trippers and druggies. Keep it real, Keep it safe, Underclock. Time governs us all.
Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid.


---
layout: post
title: Freedom and Safety Languages
tags: []
status: publish
type: post
published: true
meta:
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dsq_thread_id: '17413796'
---
Kevin Barnes describes the difference between "freedom" and "safety" languages.
Freedom languages are those languages that put the individual programmer at the center of their philosophical world.
Code Craft - Freedom languages - JournalHome.com
Some attributes of freedom languages:
Some attributes of safety languages:
Kevin claims that the philisophical differences can even be sensed just listening to how the advocates of a language describe its benefits and attempt to undermine other languages.


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