HEMOFIL M- antihemophilic factor human
Baxter Healthcare Corporation
HEMOFIL M, Antihemophilic Factor (Human) (AHF), Method M, Monoclonal Purified, is a sterile, nonpyrogenic, dried preparation of antihemophilic factor (Factor VIII, Factor VIII:C, AHF) in concentrated form with a specific activity range of 2 to 22 AHF International Units/mg of total protein. HEMOFIL M contains a maximum of 12.5 mg/mL Albumin, and per AHF International Unit, 0.07 mg polyethylene glycol (3350), 0.39 mg histidine as stabilizing agents, not more than 0.1 mg glycine, 0.1 ng mouse protein, 18 ng organic solvent (tri-n-butyl phosphate) and 50 ng detergent (octoxynol 9). In the absence of the added Albumin (Human), the specific activity is approximately 2,000 AHF International Units/mg of protein. [see Clinical Pharmacology]
HEMOFIL M is prepared by the Method M process from pooled human plasma by immunoaffinity chromatography utilizing a murine monoclonal antibody to Factor VIII:C, followed by an ion exchange chromatography step for further purification. Source material may be provided by other US licensed manufacturers. HEMOFIL M also includes an organic solvent (tri-n-butyl phosphate) and detergent (octoxynol 9) virus inactivation step designed to reduce the risk of transmission of hepatitis and other viral diseases. The process further includes a nanofiltration step between immunoaffinity chromatography and ion-exchange chromatography as an additional viral clearance step to further improve the viral safety margin of the final product.
Use of an organic solvent (tri-n-butyl phosphate; TNBP) in the manufacture of Antihemophilic Factor (Human) has little or no effect on AHF activity, while lipid enveloped viruses, such as hepatitis B and human immunodeficiency virus (HIV) would be inactivated.1 The nanofiltration step integrated into the manufacture of AHF-M further enhances the safety margin with respect to adventitious viruses.
Each bottle of HEMOFIL M is labeled with the AHF activity expressed in International Units (IU) per bottle. This potency assignment is referenced to the World Health Organization International Standard.
The purity of HEMOFIL M has been thought to influence the difficulty of producing an accurate potency measurement. Experiments have shown that to achieve accurate activity levels, such a potency assay should be conducted using plastic test tubes and pipets as well as substrate containing normal levels of von Willebrand's Factor.
In vitro studies demonstrate that the HEMOFIL M manufacturing process provides for viral reduction. These reductions are achieved through a combination of process chemistry, partitioning and/or inactivation during solvent/detergent treatment, and immunoaffinity chromatography.  B19V removal data were obtained with a Polymerase Chain Reaction (PCR) assay not correlated to an infectivity assay.
Studies for nanofiltration and other process steps, summarized in Table 1, demonstrate virus clearance during the HEMOFIL M manufacturing process using HIV-1; BVDV, a generic model for lipid enveloped RNA viruses, such as hepatitis C virus (HCV); PRV, a model for lipid enveloped DNA viruses, such as hepatitis B virus (HBV); canine parvovirus (CPV), a model for non-lipid enveloped DNA viruses, such as B19V, HAV, and MMV.
Process Step Evaluated |
Virus Clearance, log 10 |
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Lipid-enveloped |
Non-Lipid enveloped |
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HIV-1 |
BVDV |
PRV |
HAV |
CPV |
MMV |
|
Solvent/Detergent Treatment |
>4.8 |
>6.8 |
>6.9 |
NT* |
NT* |
NT* |
Immunoaffinity Chromatography |
N.A.† |
N.A.† |
N.A.† |
≥4.5 |
≥3.9 |
NT |
Nanofiltration |
>5.5 |
>4.6 |
>4.4 |
>5.4 |
NT |
>5.0 |
Cumulative Total, log10 |
>10.3 |
>11.4 |
>11.3 |
>9.9 |
≥3.9 |
>5.0 |
Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation.
The administration of HEMOFIL M provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia).
The half-life of HEMOFIL M administered to Factor VIII deficient patients has been shown to be 14.8 ± 3.0 hours.
HEMOFIL M is indicated in hemophilia A (classical hemophilia) for the prevention and control of hemorrhagic episodes.
HEMOFIL M is not indicated in von Willebrand's disease.
HEMOFIL M is contraindicated in patients with a known hypersensitivity to the active substance, to excipients, or to mouse proteins.
Allergic-type hypersensitivity reactions, including anaphylaxis, have been reported with HEMOFIL M and have been manifested by bronchospasm, dyspnea, hypotension, chest pain, facial edema, urticaria, rash, flushing, pruritus, and nausea.
The development of neutralizing antibodies (inhibitors) to Factor VIII is a known complication of the treatment of patients with Hemophilia A. Inhibitors have predominantly been reported in previously untreated patients. The risk of developing inhibitors is correlated to the extent of exposure to Factor VIII, the risk being highest within the first 20 exposure days, and to other genetic and environmental factors. The risk for inhibitor development depends on a number of factors relating to the characteristics of the patient (e.g., type of the Factor VIII gene mutation, family history, ethnicity), which are believed to represent the most significant risk factors for inhibitor formation.
Because HEMOFIL M is made from human blood, it may carry a risk of transmitting infectious agents, e.g., viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent. This also applies to unknown or emerging viruses and other pathogens.
All infections thought by a
physician possibly to have been transmitted by this product
should be reported by the physician or other healthcare provider
to Baxter Healthcare Corporation at
1-800-423-2862 (in the
U.S.) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. The physician should
discuss the risks and benefits of this product with the
patient.
Individuals who receive infusions of blood or plasma products may develop signs and/or symptoms of some viral infections, particularly non-A, non-B hepatitis. As indicated under Clinical Pharmacology, however, a group of such patients treated with HEMOFIL M did not demonstrate signs or symptoms of non-A, non-B hepatitis over observation periods ranging from three to nine months.
Identification of the clotting defect as a Factor VIII deficiency is essential before the administration of HEMOFIL M is initiated.
Evaluate patients for the development of Factor VIII inhibitors if the expected plasma Factor VIII activity levels are not attained or if bleeding is not controlled with an appropriate dose.
No benefit may be expected from this product in treating other deficiencies.
HEMOFIL M contains trace amounts of mouse protein (less than 0.1 ng/AHF activity units). The possibility exists that patients treated with HEMOFIL M may develop hypersensitivity to the mouse proteins. There have been no cases of hypersensitivity to the mouse proteins reported.
Determine the pulse rate before and during administration of HEMOFIL M. Should a significant increase occur, reduce the rate of administration or temporarily halt the injection to allow the symptoms to disappear promptly.
Perform appropriate laboratory tests on the patient's plasma at suitable intervals to ensure that adequate AHF levels have been reached and are maintained.
If the AHF content of the patient's plasma fails to reach expected levels or if bleeding is not controlled after apparently adequate dosage, the presence of inhibitor should be suspected. By appropriate laboratory procedures, the presence of inhibitor can be demonstrated and quantified in terms of AHF units neutralized by each mL of plasma or by the total estimated plasma volume.
If the inhibitor is at low levels (i.e., <10 Bethesda units per mL), after administration of sufficient AHF units to neutralize the inhibitor, additional AHF units will elicit the predicted response.
Pregnancy Category C
Animal reproduction studies have not been conducted with HEMOFIL M. The safety of HEMOFIL M for use in pregnant women has not been established. It is not known whether HEMOFIL M can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. HEMOFIL M should be given to a pregnant woman only if clearly needed.
The safety of HEMOFIL M for use in nursing mothers has not been established. It is not known whether this drug is excreted into human milk. Physicians should carefully consider the potential risks and benefits for each specific patient before prescribing HEMOFIL M. HEMOFIL M should be given to nursing mothers only if clinically indicated.
The adverse reactions presented in this section have been identified based on clinical trial experience with HEMOFIL M in patients previously treated with other Factor VIII concentrates or blood products (N = 74), and previously untreated patients (PUPs; N = 50).
| ||
Clinical Trial Adverse Reactions | ||
System Organ Class (SOC) |
Preferred MedDRA Term |
Number of Cases (Frequency Percentage) |
|
BLOOD AND LYMPHATIC SYSTEM DISORDERS |
Factor VIII inhibition |
3 (5.7%)* |
NERVOUSSYSTEM DISORDERS |
Dizziness |
1 (0.8%) |
Headache |
1 (0.8%) |
|
Dysgeusia |
1 (0.8%) |
|
GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS |
Pyrexia |
1 (0.8%) |
Infusion site inflammation |
2 (1.6%) |
HEMOFIL M was administered to 11 patients previously untreated with Antihemophilic Factor (Human). They have shown no signs of hepatitis or HIV infection following three to nine months of evaluation.
A study of 25 patients treated with HEMOFIL M and monitored for three to six months has demonstrated no evidence of antibody response to mouse protein. More than 1,000 infusions of HEMOFIL M have been administered during the clinical trials. Reported events included a single episode each of chest tightness, fuzziness and dizziness, and one patient reported an unusual taste after each infusion.
In addition to clinical trials, the following adverse reactions have been reported in the post-marketing experience, listed by MedDRA System Organ Class (SOC), then by Preferred Term.
Immune System Disorders: anaphylactic reaction, hypersensitivity
Eye Disorders: visual impairment, ocular hyperemia
Cardiac Disorders: cyanosis, bradycardia, tachycardia
Vascular Disorders: hypotension, flushing
Respiratory, Thoracic, and Mediastinal Disorders: bronchospasm, dyspnea, cough, hyperventilation
Gastrointestinal Disorders: diarrhea, vomiting, nausea, abdominal pain
Skin and Subcutaneous Tissue Disorders: urticaria, rash, pruritus, hyperhidrosis
Musculoskeletal and Connective Tissue Disorders: musculoskeletal pain
General Disorders and Administration Site Conditions: facial edema, edema, chills, fatigue, chest pain, irritability
For intravenous use only.
The expected in vivo peak AHF level, expressed as IU/dL of plasma or % (percent) of normal, can be calculated by multiplying the dose administered per kg body weight (IU/kg) by two. This calculation is based on the clinical finding by Abildgaard, et al,2 which is supported by data from the collaborative study of in vivo recovery and survival with 15 different lots of HEMOFIL M on 56 hemophiliacs that demonstrated a mean peak recovery point above the mean pre-infusion baseline of about 2.0 IU/dL per infused IU/kg body weight.3
Examples:
(1) A dose of 1750 IU AHF administered to a 70 kg patient, i.e., 25 IU/kg (1750/70), should be expected to cause a peak post-infusion AHF increase of 25 x 2 = 50 IU/dL (50% of normal).
(2) A peak level of 70% is required in a 40 kg child. In this situation the dose would be 70/2 x 40 = 1400 IU.
Recommended Dosage Schedule
Physician supervision of the dosage is required. The following dosage schedule may be used as a guide.
HEMORRHAGE | ||
Degree of hemorrhage |
Required peak post-infusion AHF activity in the blood (as % of normal or IU/dL plasma) |
Frequency of infusion |
Early hemarthrosis or muscle bleed or oral bleed |
20-40 |
Begin infusion every 12 to 24 hours for one-three days until the bleeding episode as indicated by pain is resolved or healing is achieved. |
More extensive hemarthrosis, muscle bleed, or hematoma |
30-60 |
Repeat infusion every 12 to 24 hours for usually three days or more until pain and disability are resolved. |
Life threatening bleeds such as head injury, throat bleed, severe abdominal pain |
60-100 |
Repeat infusion every 8 to 24 hours until threat is resolved. |
SURGERY | ||
Type of operation |
|
|
Minor surgery, including tooth extraction |
60-80 |
A single infusion plus oral antifibrinolytic therapy within one hour is sufficient in approximately 70% of cases. |
Major surgery |
80-100 (pre- and post-operative) |
Repeat infusion every 8 to 24 hours depending on state of healing. |
If bleeding is not controlled with the prescribed dose, determine the plasma level of Factor VIII and administer a sufficient dose of HEMOFIL M to achieve a satisfactory clinical response.
Under certain circumstances (e.g., presence of a low titer inhibitor) doses larger than those recommended may be necessary as per standard care. In patients with high titer Factor VIII inhibitors, HEMOFIL M therapy may not be effective and other therapeutic options should be considered.
The dosage and duration of treatment depend on the severity of Factor VIII deficiency, the location and extent of the bleeding, and the patient’s clinical condition. Careful control of replacement therapy is especially important in cases of major surgery or life threatening hemorrhages.
Note: Do not refrigerate after reconstitution.
Intravenous Syringe Injection
1. Attach filter needle to a disposable syringe and draw back plunger to admit air into syringe.
2. Insert needle into reconstituted HEMOFIL M.
3. Inject air into bottle and then withdraw the reconstituted material into the syringe.
4. Remove and discard the filter needle from the syringe; attach a suitable needle and inject intravenously as instructed under Rate of Administration.
5. If a patient is to receive more than one bottle of HEMOFIL M, the contents of two bottles may be drawn into the same syringe by drawing up each bottle through a separate unused filter needle. This practice lessens the loss of HEMOFIL M. Filter needles are intended to filter the contents of a single bottle of HEMOFIL M only.
HEMOFIL M is available as single-dose bottles that contain the following nominal potencies:
Nominal Potency |
Kit NDC Number |
250 IU |
0944-3940-02 |
500 IU |
0944-3942-02 |
1000 IU |
0944-3944-02 |
1700 IU |
0944-3946-02 |
Each bottle is labeled with the potency in International Units, and is packaged together with 10 mL of Sterile Water for Injection, USP, a double-ended needle, and a filter needle.
Not made with natural rubber latex.
HEMOFIL M can be stored at 2°C to 8°C (36°F to 46°F) or at room temperature, not to exceed 30°C (86°F), until expiration date noted on the package.
Do not freeze.
Information for Patients
To enroll in the confidential, industry-wide Patient Notification System, call 1-888-UPDATE U (1-888-873-2838)
Baxter and Hemofil are trademarks of Baxter International Inc.
and are registered in
the U.S. Patent and Trademark
office.
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
Revised Feb 2014
Hemofil M NF Unit Carton 250 IU
10 mL size, dried
NDC
0944-3940-02
Antihemophilic Factor (Human)
Method M, Monoclonal Purified
HEMOFIL M
Nanofiltered
FVIII
Intravenous administration only.
Administer within 3 hours after reconstitution.
Dosage and Administration: See full prescribing information.
Warning: This product is prepared from large pools of human plasma. Human blood and its components may transit infectious agents. The patient and the physician should discuss the risks and benefits of this product.
Contains no preservative.
Rx Only
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
Hemofil M NF Vial Label 250 IU
10 mL size, dried
NDC 0944-3941-01
Antihemophilic Factor (Human)
Method M, Monoclonal Purified
HEMOFIL M
Nanofiltered
FVIII
Intravenous administration only
Store at 2°- 8°C (38°- 46°F) or room temperature, not to exceed 30°C (86°F) until the expiration date noted on the package.
Dosage and Administration: see package insert.
Contains no preservative.
Rx Only
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
Hemofil M Unit Carton 500 IU
10 mL size, dried
NDC 0944-3942-02
Antihemophilic Factor (Human)
Method M, Monoclonal Purified
HEMOFIL M
Nanofiltered
FVIII
Intravenous administration only.
Administer within 3 hours after reconstitution.
Dosage and Administration: See full prescribing information.
Warning: This product is prepared from large pools of human plasma. Human blood and its components may transit infectious agents. The patient and the physician should discuss the risks and benefits of this product.
Contains no preservative.
Rx Only
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
Hemofil M Vial Label 500 IU
10 mL size, dried
NDC 0944-3943-01
Antihemophilic Factor (Human)
Method M, Monoclonal Purified
HEMOFIL M
Nanofiltered
FVIII
Intravenous administration only
Store at 2°- 8°C (38°- 46°F) or room temperature, not to exceed 30°C (86°F) until the expiration date noted on the package.
Dosage and Administration: see package insert.
Contains no preservative.
Rx Only
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
Hemofil M 1000 IU Vial Label
10 mL size, dried
NDC 0944-3944-02
Antihemophilic Factor (Human)
Method M, Monoclonal Purified
HEMOFIL M
Nanofiltered
FVIII
Intravenous administration only.
Administer within 3 hours after reconstitution.
Dosage and Administration: See full prescribing information.
Warning: This product is prepared from large pools of human plasma. Human blood and its components may transit infectious agents. The patient and the physician should discuss the risks and benefits of this product.
Contains no preservative.
Rx Only
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
10 mL size, dried
NDC 0944-3945-01
Antihemophilic Factor (Human)
Method M, Monoclonal Purified
HEMOFIL M
Nanofiltered
FVIII
Intravenous administration only
Store at 2°- 8°C (38°- 46°F) or room temperature, not to exceed 30°C (86°F) until the expiration date noted on the package.
Dosage and Administration: see package insert.
Contains no preservative.
Rx Only
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
Hemofil M Unit Carton 1700 IU
10 mL size, dried
NDC 0944-3946-02
Antihemophilic Factor (Human)
Method M, Monoclonal Purified
HEMOFIL M
Nanofiltered
FVIII
Intravenous administration only.
Administer within 3 hours after reconstitution.
Dosage and Administration: See full prescribing information.
Warning: This product is prepared from large pools of human plasma. Human blood and its components may transit infectious agents. The patient and the physician should discuss the risks and benefits of this product.
Contains no preservative.
Rx Only
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
Hemofil M NF Vial Label 1700 IU
10 mL size, dried
NDC 0944-3947-01
Antihemophilic Factor (Human)
Method M, Monoclonal Purified
HEMOFIL M
Nanofiltered
FVIII
Intravenous administration only
Store at 2°- 8°C (38°- 46°F) or room temperature, not to exceed 30°C (86°F) until the expiration date noted on the package.
Dosage and Administration: see package insert.
Contains no preservative.
Rx Only
Baxter Healthcare Corporation
Westlake Village, CA 91362 USA
U.S. License No. 140
Sterile Water Vial Label
NDC 0338-0764-61
Nonpyrogenic
Single-Dose Container
10 mL
Sterile Water for Injection, USP
for reconstitution of accompanying product
Do not use unless clear. No antimicrobial agent or other
substance has been added. Do not use for intravascular
injection without making approximately isotonic by
addition of suitable solute. Discard unused portion.
Rx Only.
This Product Contains Dry Natural Rubber.
Manufactured by
Baxter Healthcare Corporation
Deerfield, IL 60015 USA
Imported by
Baxter
Corporation
Toronto, Ontario
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| Labeler - Baxter Healthcare Corporation (039121363) |
| Establishment | |||
| Name | Address | ID/FEI | Business Operations |
|---|---|---|---|
| BAXTER HEALTHCARE CORPORATION | 085206634 | MANUFACTURE |
| Establishment | |||
| Name | Address | ID/FEI | Business Operations |
|---|---|---|---|
| Baxter Healthcare Corporation | 001728059 | MANUFACTURE |


{% extends 'marketplace/base.html' %} {% block pagecontents %}
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AWS::SageMaker::Model
The AWS::SageMaker::Model
resource to create a model to host at an Amazon
SageMaker endpoint. For more information, see Deploying a Model on
Amazon SageMaker Hosting Services in the Amazon SageMaker Developer
Guide.
Syntax
To declare this entity in your AWS CloudFormation template, use the following syntax:
JSON
{ "Type" : "AWS::SageMaker::Model", "Properties" : { "ExecutionRoleArn" :
String
, "PrimaryContainer" : ContainerDefinition, "Containers" : [ ContainerDefinition,...], "ModelName" :String
, "VpcConfig" : VpcConfig, "Tags" : [ Tag, ... ] } }
YAML
Type: "AWS::SageMaker::Model" Properties: ExecutionRoleArn:
String
PrimaryContainer: ContainerDefinition Containers: - ContainerDefinition ModelName:String
VpcConfig: VpcConfig Tags: - Tag
Properties
ExecutionRoleArn
-
The Amazon Resource Name (ARN) of the IAM role that Amazon SageMaker can assume to access model artifacts and docker image for deployment on ML compute instances. Deploying on ML compute instances is part of model hosting. For more information, see Amazon SageMaker Roles.
Required: Yes
Type: String
Update requires: Replacement
PrimaryContainer
-
The location of the primary docker image containing inference code, associated artifacts, and custom environment map that the inference code uses when the model is deployed into production.
Required: Yes
Type: Amazon SageMaker Model ContainerDefinition
Update requires: Replacement
Containers
-
Specifies the containers in the inference pipeline.
Required: No
Type: List of Amazon SageMaker Model ContainerDefinition
Update requires: Replacement
ModelName
-
The name of the model.
Required: No
Type: String
Update requires: Replacement
VpcConfig
-
A VpcConfig object that specifies the VPC that you want your model to connect to. Control access to and from your model container by configuring the VPC. For more information, see Protect Models by Using an Amazon Virtual Private Cloud.
Required: No
Type: Amazon SageMaker Model VpcConfig
Update requires: Replacement
Tags
-
An array of key-value pairs. For more information, see Using Cost Allocation Tags in the AWS Billing and Cost Management User Guide.
Required: No
Type: List of Resource Tag
Update requires: No interruption
Return Values
Ref
When you pass the logical ID of an AWS::SageMaker::Model
resource to
the intrinsic Ref
function, the function returns the Amazon Resource Name (ARN) of
the model, such as
arn:aws:sagemaker:us-west-2:012345678901:model/mymodel
.
For more information about using the Ref
function, see Ref.
Fn::GetAtt
Fn::GetAtt
returns a value for a specified attribute of this type. The
following are the available attributes and sample return values.
ModelName
-
The name of the model, such as
MyModel
.
For more information about using Fn::GetAtt
, see Fn::GetAtt.
Examples
SageMaker Endpoint Example
The following example creates an endpoint configuration from a trained model, and then creates an endpoint.
JSON
{ "Description": "Basic Hosting entities test. We need models to create endpoint configs.", "Mappings": { "RegionMap": { "us-west-2": { "NullTransformer": "12345678901.dkr.ecr.us-west-2.amazonaws.com/mymodel:latest" }, "us-east-2": { "NullTransformer": "12345678901.dkr.ecr.us-east-2.amazonaws.com/mymodel:latest" }, "us-east-1": { "NullTransformer": "12345678901.dkr.ecr.us-east-1.amazonaws.com/mymodel:latest" }, "eu-west-1": { "NullTransformer": "12345678901.dkr.ecr.eu-west-1.amazonaws.com/mymodel:latest" }, "ap-northeast-1": { "NullTransformer": "12345678901.dkr.ecr.ap-northeast-1.amazonaws.com/mymodel:latest" }, "ap-northeast-2": { "NullTransformer": "12345678901.dkr.ecr.ap-northeast-2.amazonaws.com/mymodel:latest" }, "ap-southeast-2": { "NullTransformer": "12345678901.dkr.ecr.ap-southeast-2.amazonaws.com/mymodel:latest" }, "eu-central-1": { "NullTransformer": "12345678901.dkr.ecr.eu-central-1.amazonaws.com/mymodel:latest" } } }, "Resources": { "Endpoint": { "Type": "AWS::SageMaker::Endpoint", "Properties": { "EndpointConfigName": { "Fn::GetAtt" : ["EndpointConfig", "EndpointConfigName" ] } } }, "EndpointConfig": { "Type": "AWS::SageMaker::EndpointConfig", "Properties": { "ProductionVariants": [ { "InitialInstanceCount": 1, "InitialVariantWeight": 1, "InstanceType": "ml.t2.large", "ModelName": { "Fn::GetAtt" : ["Model", "ModelName" ] }, "VariantName": { "Fn::GetAtt" : ["Model", "ModelName" ] } } ] } }, "Model": { "Type": "AWS::SageMaker::Model", "Properties": { "PrimaryContainer": { "Image": { "Fn::FindInMap" : [ "AWS::Region", "NullTransformer"] } }, "ExecutionRoleArn": { "Fn::GetAtt" : [ "ExecutionRole", "Arn" ] } } }, "ExecutionRole": { "Type": "AWS::IAM::Role", "Properties": { "AssumeRolePolicyDocument": { "Version": "2012-10-17", "Statement": [ { "Effect": "Allow", "Principal": { "Service": [ "sagemaker.amazonaws.com" ] }, "Action": [ "sts:AssumeRole" ] } ] }, "Path": "/", "Policies": [ { "PolicyName": "root", "PolicyDocument": { "Version": "2012-10-17", "Statement": [ { "Effect": "Allow", "Action": "*", "Resource": "*" } ] } } ] } } }, "Outputs": { "EndpointId": { "Value": { "Ref" : "Endpoint" } }, "EndpointName": { "Value": { "Fn::GetAtt" : [ "Endpoint", "EndpointName" ] } } } }
YAML
Description: "Basic Hosting entities test. We need models to create endpoint configs." Mappings: RegionMap: "us-west-2": "NullTransformer": "123456789012.dkr.ecr.us-west-2.amazonaws.com/mymodel:latest" "us-east-2": "NullTransformer": "123456789012.dkr.ecr.us-east-2.amazonaws.com/mymodel:latest" "us-east-1": "NullTransformer": "123456789012.dkr.ecr.us-east-1.amazonaws.com/mymodel:latest" "eu-west-1": "NullTransformer": "123456789012.dkr.ecr.eu-west-1.amazonaws.com/mymodel:latest" "ap-northeast-1": "NullTransformer": "123456789012.dkr.ecr.ap-northeast-1.amazonaws.com/mymodel:latest" "ap-northeast-2": "NullTransformer": "123456789012.dkr.ecr.ap-northeast-2.amazonaws.com/mymodel:latest" "ap-southeast-2": "NullTransformer": "123456789012.dkr.ecr.ap-southeast-2.amazonaws.com/mymodel:latest" "eu-central-1": "NullTransformer": "123456789012.dkr.ecr.eu-central-1.amazonaws.com/mymodel:latest" Resources: Endpoint: Type: "AWS::SageMaker::Endpoint" Properties: EndpointConfigName: !GetAtt EndpointConfig.EndpointConfigName EndpointConfig: Type: "AWS::SageMaker::EndpointConfig" Properties: ProductionVariants: - InitialInstanceCount: 1 InitialVariantWeight: 1.0 InstanceType: ml.t2.large ModelName: !GetAtt Model.ModelName VariantName: !GetAtt Model.ModelName Model: Type: "AWS::SageMaker::Model" Properties: PrimaryContainer: Image: !FindInMap [RegionMap, !Ref "AWS::Region", "NullTransformer"] ExecutionRoleArn: !GetAtt ExecutionRole.Arn ExecutionRole: Type: "AWS::IAM::Role" Properties: AssumeRolePolicyDocument: Version: "2012-10-17" Statement: - Effect: "Allow" Principal: Service: - "sagemaker.amazonaws.com" Action: - "sts:AssumeRole" Path: "/" Policies: - PolicyName: "root" PolicyDocument: Version: "2012-10-17" Statement: - Effect: "Allow" Action: "*" Resource: "*" Outputs: EndpointId: Value: !Ref Endpoint EndpointName: Value: !GetAtt Endpoint.EndpointName


[§329B-8] Rulemaking. The department may adopt rules under chapter 91 necessary to implement this chapter. [L 1990, c 236, pt of §1]


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---
layout: post
authors: ["Justin Kitzes"]
title: Second Round at Lawrence Berkeley
date: 2013-03-13
time: "09:00:00"
tags: ["Lawrence Berkeley National Laboratory"]
---
Last week we finished up our second workshop at Lawrence Berkeley Lab. This
time around, we tried a more free-form version of the feedback exercise in
which students live-typed their feedback into an Etherpad
at the end of each day. This went very well, as
it gave us time to gather unique comments, get a rough idea of the amount of
support for each comment, and to respond to some of the comments in real time.
We asked three questions: what was good, what was bad/confusing, and what we
didn't do or talk about that we should have.
The Good
- Introduction to python and how to install things with command lines
- Understanding python objects, classes, functions, methods, etc.
- Thinking about how to structure the directories for a project
- Hearing how regular Python users use Python (+1)
- Just getting finally to write some .py code!
- Real world example-driven exercises
- Knowledge of helpful data types in Python
- iPython notebook and Etherpad are amazing (+1)
- The party on the Etherpad !!!!! (+1 +1) [Ed: the students had some fun "passing notes" in the Etherpad]
- Patient, fast, specific help (+1)
- An explanation of git from people who use git (+1 +1 +1)
- Inside structure of git
- You put a lot of things in my brain in a very short time (+1)
- Standalone scripts is my new goal for my code!
- Start thinking about how to test code for reusability
- Danish and coffee / snacks / food juice
The Bad or Confusing
- Python version issues, especially multiple Python versions on same system (+1 +1 +1)
- Relationship between Anaconda/IPython/Enthought/system Python
- Use of iPython Notebook vs console, roles in real-world code development (+1)
- Glossary/handout on Python would have been helpful for beginners
- Most of the Unix tutorial was extremely basic (+1 +1 +1) [Ed: There were two follow ups to this comment in which students said they needed the basic tutorial badly.]
- Worrying about whether to abandon perl and R for python - then I'd have to start the learning curve all over.
- Too fast for beginners, but noticed that others were bored (+1)
- Not enough 'signposting' during talks/lessons
- It's over now :\
Things We Didn't Do or Talk About But Should Have
- Online "getting started with Unix" tutorial before class (+1 +1 +1)
- Making and annotating/labelling plots, more Matplotlib (+1 +1)
- Discussion of computational and memory efficiency
- "Best practices" for developing and maintaining code (+1 +1 +1 +1)
- Fitting data (+1 +1)
- How to share code, etc. with those who don't use version control
- Working with specific types of data (ie, DNA)
- More about modules and importing, common bugs, etc.
- Is there a better way to find help than google and stackoverflow?
- Overhead when working with extremeley large data sets
Thanks to Shreyas Cholia and to instructors Matthew Brett, Cindee Madison, and Ariel Rokem and helpers Paul Ivanov and Matt Terry.


I would like to become a established full stack developer and would like to be able to create web spplications as well as desktop and mobile
I would like to develop consistency in my coding as well as learn how to collaborate on projects more effectivley whilst developing my leadership and human skills
I am able to lead teams and project manage effectively. I also am able to share my ideas and thoughts effectivley
My limitations are not being consistent and being able to focus for long periods of time as I get distracted very easily.
I will need to stay in regular communication with the facilitators as well as keep a journal or a to do list to make sure I hold myself accountable for my progress.
I will seek help from the tutors as well as other students who maybe able to help with some of my limitations.
Just guidance mentorship and support
Yes I go to church every friday for an hour so I will need to work around this or take my lunch during this time.


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owned
`Prev `__
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`Next <../P.html>`__
--------------
**owned**
1. [cracker slang; often written “0wned”] Your condition when your
machine has been cracked by a root exploit, and the attacker can do
anything with it. This sense is occasionally used by hackers.
2. [gamers, IRC, crackers] To be dominated, controlled, mastered. For
example, if you make a statement completely and utterly false, and
someone else corrects it in a way that humiliates or removes you, you
are said to “have been owned” by that person. When referring to games,
“I own0r UT GOTYE” means that one has mastered Unreal Tournament, Game
of the Year Edition to such a level that even the hardest AI characters
are mere lunchmeat, and that no ordinary mortal player would even
receive a point in competition. There are several spelling variants:
0wned, 0wn0r3d, even pwn0r3d. Hackers do not use this sense.
--------------
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+----------------------------------+----------------------------+-------------------------+
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+----------------------------------+----------------------------+-------------------------+


THE NUTTY PROFESSOR A film review by Steve Rhodes Copyright 1996 Steve Rhodes
RATING (0 TO ****): * 1/2
On the way back from three days at the parent-child Space Camp with my son where he and I heard and saw what exemplifies the best in America, the whole family stopped to see the remake of THE NUTTY PROFESSOR. In quite a contrast, the construction of this movie is symptomatic of much of the current degradation of our society.
In the remake, producers Brian Grazer and Russell Simmon manage to transform a simple kids' comedy into the filthiest kids' movie I can ever remember seeing. Certainly the show does have many funny parts, and Eddie Murphy does demonstrates tremendous acting bandwidth, nevertheless, as a picture marketed to youngsters and where the audience is filled with kids under ten, this film exemplifies all that is wrong in Hollywood today.
Don't misread me. I am a libertarian when it comes to films. If produces want movies overflowing with bad language, that is a judgment call they get to make. In some movies it works (PULP FICTION or GLENGARRY GLEN ROSS) and others it doesn't (GIRLS TOWN). However, in shows where the trailers make it look like good humored fun for kids, where the original movie was silly and innocent, where you know that a large portion of the audience will be kids under 10 and where the rating is PG-13, one should not expect a constant stream of filthy language including crude sexual jokes about mothers.
A few years ago, this movie would certainly have gotten an R, which would, of course, have decreased the box office take. To me this movie speaks volumes about the state of the country. Adults should have their shows, but why do we think children should be taught the B and the N words? Do we want them to use them to their friends? Do we want them to begin insulting each other with horrible sexual innuendoes about each other's mothers?
The movie does have some good aspects and several big laughs, although not near enough for an adult audience. The film opens with enormously fat Professor Sherman Klump (Eddie Murphy) watching a Richard Simmons look-alike doing an exercise show on television. The film starts off quite promisingly. The professor is a brilliant, but nerdy scientist. He accidentally released hundreds of hamsters around the campus. My favorite small scene has one of them running up one student's leg.
The plot by writers Barry Blaustein, Steve Oedekerk, Tom Shadyac, and David Sheffield starts off to be a comedy with some serious messages. The movie has the professor inventing a drug to become thin. The messages surround how hard it is to get thin and how fat people are stigmatized and humiliated by society. The first message is trivialized, and the second is contradicted. The movie turns into a diatribe against fat people regardless of the movie's tacked on and moralistic ending. As a person who was fat for the first twenty years of my life and who then lost one hundred pounds (to 135) and kept it off for the last thirty, I am well aware of the importance of the messages that this show only flirts with.
The show by director Tom Shadyac (ACE VENTURA: PET DETECTIVE) soon goes straight for the gutter. In an impressive acting demonstration by Murphy we have him playing all of the roles of a large family with obese members.
Other scenes in the movie, thank goodness, do work better. In a nightmare scene, the professor sees himself on the operating table. The doctors look on in horror as one shrieks, "He's getting fatter, and we can't stop it!" Looking like he will explode at any moment he gets out of the hospital only to become a GODZILLA sized creature who terrorizes the city.
Like an alcoholic, the professor wakes one morning after a night of binging to finally proclaim that is the last time. After that the show becomes a fat and thin version of DR. JEKYLL AND MR. HYDE.
 Of course, he is out to steal the professor's girlfriend, Carla Purty (Jada Pinkett). Murphy, who was so touching in COMING TO AMERICA, does his crude nightclub routine though most of the show. That he can play seven roles is an amazing testament to his inherent talents and to some great special make-up effects by Rick Baker, but why couldn't the sweet Murphy come out when the picture calls for it? Why?
THE NUTTY PROFESSOR runs 1:35. It is an R picture, but with an MPAA rating of PG-13. Do not take kids under 13 to see the show, and I would prefer to see teenagers be mature before going. Although we tried to get him to leave, Jeffrey (age 7) refused. In the end he gave the film a thumbs sideways. We developed a new family rule after the film that whenever a parent says leave, there are no more negotiations. We try to investigate PG-13 films, but were lolled by the innocent trailers and the name of the picture to think this one would be okay. I do not recommend this lame picture to any age group, and I give it * 1/2 for a few nice laughs and excellent special effects.
**** = One of the top few films of this or any year. A must see film. *** = Excellent show. Look for it. ** = Average movie. Kind of enjoyable. * = Poor show.  Totally unbearable.
REVIEW WRITTEN ON: August 25, 1996
Opinions expressed are mine and not meant to reflect my employer's.
The review above was posted to the
rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).
The Internet Movie Database accepts no responsibility for the contents of the
review and has no editorial control. Unless stated otherwise, the copyright
belongs to the author.
Please direct comments/criticisms of the review to relevant newsgroups.
Broken URLs inthe reviews are the responsibility of the author.
The formatting of the review is likely to differ from the original due
to ASCII to HTML conversion.
Related links: index of all rec.arts.movies.reviews reviews


Discoverthreejs.com
Morph Target Control
Left Quad (Non-indexed)
Explode:
0
Right Quad (Indexed)
Rotate:
0
Scale:
0
Materials
Toggle Wireframe


Welcome to my to-do-list website
There are two tables which can be used, they are tasks and people with
the following functions:
- Read All (returns all data set)
- Read by (returns a specific data set - required an ID - Currently Not Working)
- Create (creates a new data set)
- Update (updates a data set - requires an ID)
- Delete (delete a data set - requires an ID)
Please navigate to the Tasks or People pages on the navigation bar to
perform the functions.


--- layout: post title: NYX Mood Lip Gloss - MLG01 tags: - NYX status: publish type: post published: true meta: _edit_last: '2' wp_plus_one_redirect: '' wp_plus_one_disabled: '1' _aioseop_title: NYX Mood Lip Gloss MLG01 _aioseop_keywords: NYX Mood Lip Gloss MLG01 review and swatches _yoast_wpseo_linkdex: '0' _thumbnail_id: '3957' _yoast_wpseo_focuskw: '' _yoast_wpseo_title: '' _yoast_wpseo_metadesc: '' _yoast_wpseo_metakeywords: '' _yoast_wpseo_meta-robots-noindex: '0' _yoast_wpseo_meta-robots-nofollow: '0' _yoast_wpseo_meta-robots-adv: none _yoast_wpseo_sitemap-include: ! '-' _yoast_wpseo_sitemap-prio: ! '-' _yoast_wpseo_canonical: '' _yoast_wpseo_redirect: '' ---
Only if there can be a product which changes with the mood of a gal, has to be the best invention by a human ever and boy's best friend ever.
When I received this, I was in a really good mood, because dear Ana sent me this in her International giveaway.. yohooo. NYX Mood lip gloss changes colors and works as a mild gloss and can be paired with any lipcolor, but this is certainly not on my list for future purchase.... reason I am just not in mood :P Price: Rs.440 in India, but in US its for 4$Claims: Magic lip gloss starts off clear then turns into the most perfect shade of reddish pink on your lips.It’s a tube of heavenly shiny bliss and your lips couldn’t be any more natural and sexier
My Experience: Its a clear gloss the minute its out of tube, then takes up a very mild pink color, which looks good on the lips. Packaging is very travel friendly, easy to squeeze out and apply. This is one shade, you don't have to think twice before buying, but dries up my lips. I have to use a lip balm underneath. Thats why I prefer to pick up tinted lip balm over this, but gals who don't have dry lips can surely give this a try.
What I like:


why positioning
When you lay out a design for a webpage— whether or not you already have aspirations for a font choice and and click actions— you have to understand its underlying structure. HTML will provide the page's content, but HTML and CSS work together to give the page its look, and its legibility for people. Since humans understand visual information better when distinct topics are displayed separately, that's how most webpages are set up: organized into boxes. Positioning puts all those boxes in order so we can understand it.
the four values
Every CSS attribute is divided from its value with a colon and closed with a semicolon, like so: attribute: value;. Our relevant attribute, position, has 4 valid values:
- static
- relative
- absolute
- fixed
position: static;
Static positioning has also been called "normal flow" by Jon Duckett, for good reason: static is the default value assigned to the position attribute. You'll never need to type "position: static;" but it's good to remember that the linear layout of HTML is not changed by static positioning. Sidebar: This means that block-level elements (which get a line break) will have their own row, while inline elements will appear on the line of the previous element.
position: relative;
Relative positioning allows an element to be adjusted relative to its 'normal' position. Its location can be changed, but the start point wil always be where the element would fall in static positioning. By adjusting the margin, padding, or top-right-bottom-left attributes, the element will move accordingly from that start point.
position: absolute;
Absolute positioning will position an element relative to its parent element's position. The child copies the parent: by default, the top-left of an absolutely positioned element will coincide with the top-left of its parent element. To make use of the element's absolute positioning, attributes like margin, padding or top can be used to change the position (as in relative positioning).
position: fixed;
Fixed positioning is actually a type of absolute positioning which takes the viewport as its 'parent' element. Fixed-position elements do not move on the browser; other elements move under or around it.
structure and positioning
These four values for positioning your HTML elements create just about all webpages. Each value has its use. Fixed-position header bars (which stay visible at the top as you scroll down) are found from blogs to online stores to new sites; absolute, relative and static positioning spread visual interest all across the web. Tinker around and you'll find they can be infinitely, infuriatingly adjustable, and just as useful.


Skills
Web Development
- JavaScript
- ReactJS
- Redux
- Node.js
- Express.js
- MongoDB
- Mongoose
- HTML5
- CSS/SCSS
- jQuery
- Mocha.js
- JSON
- PHP/MySQL
- WordPress
Web Design
- Desktop and Mobile Web Design
- User Experience
- User Interface Design
- Information Architecture
- Copy Writing and Editing
Software
- Adobe Creative Suite
- Sketch
- InVision App
- Visual Studio Code
- Postman
- Robo 3T
Subjects Taught
- Portfolio
- UI/UX
- JavaScript
- HTML5/CSS
- Mobile Web Design
- WordPress
- Branding
- Typography
Projects
GoldStar view on Github »
September 2017
- Educational Flash Card application using the Quizlet API.
- Built using Redux, ReactJS, MongoDB, Express JS, NodeJS.
LilTetris view on Github »
September 2017
- Tetris-style game with user authentication and database to store high scores.
- Built using Redux, ReactJS, MongoDB, Express JS, NodeJS.
Adventure Game view on Github »
August 2017
- Zork-style text adventure game.
- Built using ReactJS and NodeJS.
Jubilant Disco view on Github »
August 2017
- Server-side application matching users based on favorite albums, using the Discogs API.
- Built using MongoDB, Express JS, NodeJS.
Bookbag view on Github »
June 2017
- Book recommendation application using the TasteDive API.
- Built using ExpressJS and NodeJS.
Engineering Design Team Beaverton, OR
September 2016–October 2016
- Designed and delivered a five-day series of lectures on modern UI and UX practices.
cuny.edu New York, NY
June 2015–July 2015
- Led workshops instructing web design and development teams in JavaScript and jQuery.
Experience
Various Colleges, Portland, OR and New York, NY
Assistant Professor, October 2002–present
- Taught web design and development courses including HTML5/CSS, JavaScript, User Interface Design, and User Experience.
- Participated on a variety of curriculum design and portfolio review committees.
- Schools include Portland Community College, Clark College, Fashion Institute of Technology (FIT), New York City College of Technology (City Tech), York College, and Katharine Gibbs.
The Art Institute of New York City, New York, NY
Senior Lead Instructor, January 2008–July 2016
- Taught a variety of courses in the Web Design/Interactive Media department.
- Introduced emerging technologies into the classroom and department: HTML5, CSS3, jQuery, WordPress, MAMP, mobile web development, social network APIs.
- Advised students through the process of obtaining and succeeding at web industry internships as departmental internship coordinator.
- Led a committee in rewriting curriculum to emphasize design fundamentals (typography, color theory, grid) and to lessen Flash content in favor of HTML5, CSS, and JavaScript.
Simple Circle LLC, New York, NY
Web Developer, September 2005–Feb 2010
- Developed innovative, database-driven websites for clients such as Mr. Wonderful, Creativity Magazine, PromoLift, Studio 5 in 1, and Gary Baseman Illustration.
- Maintained Sitecontrol, a custom-built PHP/MySQL-driven content management system that allowed website owners to add, remove, and update website content.
Bozell Inc., New York, NY
Web Designer/Developer, Aug 2001–Jun 2002
- Co-founded the agency’s interactive department.
- Established intranet to streamline interactive department workflow.
- Created Flash banners and HTML landing pages for online broker Datek.
Education
Alchemy Code Lab, Portland, OR
Certificate in Full Stack JavaScript, September 2017
Vermont College, Montpelier, VT
MFA Fine Art, August 2006
University of Arizona, Tucson, AZ
BFA Studio Art, May 1999


Senior Member: Alfonso Castrejón-pita
President : Kishan Makwana
Secretary : Avishek Mondal
IT Officer : Alberico Santiano
Webmaster : Soroush Faghihi Kashani


1
Nay, I swear by the Day of Resurrection;
2
Nay, I swear by the accusing soul (that this Scripture is true).
3
Thinketh man that We shall not assemble his bones ?
4
Yea, verily. We are Able to restore his very fingers!
5
But man would fain deny what is before him.
6
He asketh: When will be this Day of Resurrection ?
7
But when sight is confounded
9
And sun and moon are united,
10
On that day man will cry: Whither to flee!
12
Unto thy Lord is the recourse that day.
13
On that day man is told the tale of that which he hath sent before and left behind.
14
Oh, but man is a telling witness against himself,
15
Although he tender his excuses.
16
Stir not thy tongue herewith to hasten it.
17
Lo! upon Us (resteth) the putting together thereof and the reading thereof.
18
And when We read it, follow thou the reading;
19
Then lo! upon Us (resteth) the explanation thereof.
20
Nay, but ye do love the fleeting Now
22
That day will faces be resplendent,
24
And that day will other faces be despondent,
25
Thou wilt know that some great disaster is about to fall on them.
26
Nay, but when the life cometh up to the throat
27
And men say: Where is the wizard (who can save him now) ?
28
And he knoweth that it is the parting;
29
And agony is heaped on agony;
30
Unto thy Lord that day will be the driving.
31
For he neither trusted, nor prayed.
33
Then went he to his folk with glee.
34
Nearer unto thee and nearer,
35
Again nearer unto thee and nearer (is the doom).
36
Thinketh man that he is to be left aimless ?
37
Was he not a drop of fluid which gushed forth ?
38
Then he became a clot; then (Allah) shaped and fashioned
39
And made of him a pair, the male and female.
40
Is not He (Who doeth so) Able to bring the dead to life ?


Input your data, view statistics or take a quiz!
What is vaccination ?
Vaccination is a simple, safe, and effective way of protecting people against harmful diseases, before they come into contact with them. It uses your body’s natural defenses to build resistance to specific infections and makes your immune system stronger. Vaccines train your immune system to create antibodies, just as it does when it’s exposed to a disease. However, because vaccines contain only killed or weakened forms of germs like viruses or bacteria, they do not cause the disease or put you at risk of its complications. Most vaccines are given by an injection, but some are given orally (by mouth) or sprayed into the nose.
Why is vaccination important?
Vaccination is a safe and effective way to prevent disease and save lives – now more than ever. Today there are vaccines available to protect against at least 20 diseases, such as diphtheria, tetanus, pertussis, influenza and measles. Together, these vaccines save the lives of up to 3 million people every year. When we get vaccinated, we aren’t just protecting ourselves, but also those around us. Some people, like those who are seriously ill, are advised not to get certain vaccines – so they depend on the rest of us to get vaccinated and help reduce the spread of disease. During the COVID-19 pandemic, vaccination continues to be critically important. The pandemic has caused a decline in the number of children receiving routine immunizations, which could lead to an increase in illness and death from preventable diseases. WHO has urged countries to ensure that essential immunization and health services continue, despite the challenges posed by COVID-19.More information about the importance of vaccines is available here.
Takecare!
The human coronavirus is commonly spread through respiratory droplets in the air from a sick person, close personal contact, or by touching a surface with the virus on it. You can take steps to protect yourself and prevent the spread of the virus by washing your hands often, not touching your face, cleaning frequently touched surfaces, avoiding close contact with sick people, and practicing good respiratory hygiene.
-
Clean your hands
Wash your hands regularly with soap and water for at least 20 seconds,* says HealthLink BC. If soap and water aren’t readily available, use a hand sanitizer that contains at least 60% alcohol. Cleaning your hands often helps to lower your risk of infection and reduce the spread of infection to others.
-
Avoid touching your face
Take special care not to touch your eyes, nose, and mouth with unwashed hands, since these are the most likely ways for the virus to enter your body.
 If you have a cough or fever, seek medical attention.


{% extends 'base2.html' %} {% load wac_tags %} {% block main_content %}
The password reset link was invalid, possibly because it has already been used. Please request a new password reset.


I am on the Orakei Youth Board, which advises the Local Board. I also sit on the wider Council Youth Advisory Panel working party helping craft the YAP selection process, and have advised the national Ministry of Social Development during the review of their youth programmes.
I am a High School Ambassador for UN Youth NZ and a Build Hope leader for Amnesty Aotearoa New Zealand. I run both of those clubs at Auckland Grammar School. They both educate teens on the issues and help prepare them for advocacy, as well as take part in activism on the issues.
I have participated in Google Code-In in 2015 and 2016, helping open-source initiatives with their coding. Over the two years I have helped Free Open-Source Software Asia, and the Sustainable Computing Research Centre with their programmes, including DengueMap, a web application helping track mosquito breeding in an effort to stop mosquito-bourne diseases.


You need to create a directory where GLAMpipe can save its data.
Then write full path to "data path" field and click "set data path".
You can download latest node set from web by clicking the button below. Remember to load nodes after download finishes.
You can load (or reload) nodes by clicking the button below.


Daily Digest #24
- 3D engine entirely made of MS Excel formulae : Enjoy this Doom.xls file ! – Full of awesomeness, can’t believe Excel can do this.
- A Year Away From Mac OS
- Readrust – Kumpulan artikel, tutorial tentang Rust.
- Analytics for rails codes
- Rocksandra - Open-sourcing a 10x reduction in Apache Cassandra tail latency
- Linux on a MacBook Pro 14,3
- Getting Started with NativeScript-Vue 1.0
Daily Digest #23
- OpenAPI–An eBay Perspective
- The easy way to start automatically testing your website
- John Carmack on OpenBSD, C++ & machine learning
- When is a senior engineer not a senior engineer?
- Persistent datastructures with Go
- Go performance optimization book
- How to Write CSS That Works in Every Browser, Even the Old Ones
Daily Digest #22
- HotSwap: Bringing hot code reloading to Buck
- Big, fast, easy data with KSQL
- How to monitor Istio, the Kubernetes service mesh
- How to build a deep learning model in 15 minutes
- Meet Bandaid, the Dropbox service proxy
- How the Godfather of Cyberpunk would write software
- Our Favorite Elasticsearch Features: Part 2 - Index Aliases
Daily Digest #21
- How We Built Wallaroo to Process Millions of Messages/Sec with Microsecond Latencies
- What to expect when you decide to migrate from Javascript to Typescript
- Context information storage for asyncio
- Future Proofing Our Cloud Storage Usage
- What I learnt from building 3 high traffic web applications on an embedded key value store.
- The dramatic impersonation : a developer horror tale
- It’s Resilient CSS Week


Research and analysis
Review of clinical and educational psychology training arrangements report
Findings and recommendations from the National College for Teaching and Leadership (NCTL) and Health Education England (HEE) training review.
Documents
Ref:
NCTL-20013-2016
PDF
,
494KB
,
44 pages
Details
This cross department review looked at the scope for a more flexible clinical and educational psychology workforce, through greater integrated training.
The review had 2 strands:
-
The potential for reform. This focused on the professional standards, and current curriculum/training for clinical and educational psychologists to identify what was possible.
-
Improved psychology workforce planning. This strand considered how the 2 departments could improve workforce planning and commission for the professions.


{% extends "logical/database/details/base.html" %} {% load admin_static dbaas_tags system_config %} {% block extrastyle %} {{ block.super }} {% endblock %} {% block tab %}
{% include "admin/confirmation_modal.html" with modal_id="upgrade_patch" confirmation_message="Are you sure you want to upgrade patch?" box_title="Upgrading the patch" button_type="submit" button_value="Upgrade" button_name="upgrade_patch" id_optional="id=id_upgrade_patch_btn_modal" %} {% include "admin/confirmation_modal.html" with modal_id="upgrade_patch_retry" confirmation_message="Are you sure you want to retry upgrade patch?" box_title="Retring to upgrade the patch" button_type="submit" button_value="Upgrade Retry" button_name="upgrade_patch_retry" id_optional="id=id_upgrade_patch_retry_btn_modal" %} {% include "admin/confirmation_modal.html" with modal_id="migrate_plan" confirmation_message="Are you sure you want to migrate plan?" box_title="Migrating plan" button_type="submit" button_value="Migrate Plan" button_name="migrate_plan" id_optional="id=id_migrate_plan_btn_modal" %} {% include "admin/confirmation_modal.html" with modal_id="migrate_plan_retry" confirmation_message="Are you sure you want to retry migrating plan?" box_title="Retrying to migrate plan" button_type="submit" button_value="Migrate Plan Retry" button_name="migrate_plan_retry" id_optional="id=id_migrate_plan_retry_btn_modal" %} {% include "admin/confirmation_modal.html" with tag_type="a" modal_id="execute_scheduled_maintenance" confirmation_message="Are you sure you want execute the task now ?" box_title="Execute Scheduled Task" button_name="execute_scheduled_maintenance" id_optional="id=id_execute_scheduled_maintenance_btn_modal" %} {% include "admin/maintenance_confirmation_modal.html" with modal_id="save_submit_modal" confirmation_message="You have tasks scheduled. You want to put in your new maintenance window ?" box_title="Change Scheduled tasks" button_type="submit" button_value="save_and_update_task" button_no_value="Save" button_name="_save" extra_attributes=onclick_attrib%} {% endblock %} {% block js_footer %} {{ block.super }} {% endblock %}


|
GPGPU-Sim
|
#include <shader.h>
Public Member Functions | |
| shader_core_stats (const shader_core_config *config) | |
| ~shader_core_stats () | |
| void | new_grid () |
| void | event_warp_issued (unsigned s_id, unsigned warp_id, unsigned num_issued, unsigned dynamic_warp_id) |
| void | visualizer_print (gzFile visualizer_file) |
| void | print (FILE *fout) const |
| const std::vector< std::vector< unsigned > > & | get_dynamic_warp_issue () const |
| const std::vector< std::vector< unsigned > > & | get_warp_slot_issue () const |
Private Attributes | |
| const shader_core_config * | m_config |
| traffic_breakdown * | m_outgoing_traffic_stats |
| traffic_breakdown * | m_incoming_traffic_stats |
| std::vector< std::vector< unsigned > > | m_shader_dynamic_warp_issue_distro |
| std::vector< unsigned > | m_last_shader_dynamic_warp_issue_distro |
| std::vector< std::vector< unsigned > > | m_shader_warp_slot_issue_distro |
| std::vector< unsigned > | m_last_shader_warp_slot_issue_distro |
Friends | |
| class | power_stat_t |
| class | shader_core_ctx |
| class | ldst_unit |
| class | simt_core_cluster |
| class | scheduler_unit |
| class | TwoLevelScheduler |
| class | LooseRoundRobbinScheduler |
|
inline |
| void shader_core_stats::event_warp_issued | ( | unsigned | s_id, |
| unsigned | warp_id, | ||
| unsigned | num_issued, | ||
| unsigned | dynamic_warp_id | ||
| ) |
|
inline |
|
inline |
| void shader_core_stats::visualizer_print | ( | gzFile | visualizer_file | ) |
|
friend |
|
friend |
|
friend |
|
friend |
|
private |
|
private |
|
private |
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private |
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private |
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private |
|
private |


Petter Who?
Petter Jorgensen, visiting from Norway, swept Montana Prestige Cup
cyclocross races #3 and #4 this past weekend in Bozeman.
For Saturday, the annual course at Lindley Park was redesigned. A steep,
off camber turn at the corner of the park had to be taken slowly to avoid
sliding onto Main street and riders had to stay alert not to miss turns
obscurely flagged in the open grass.
Fifty minutes before the 3:00 start time, the rain turned to snow flurries
and riders were still trying to decide whether or not to race.

Jorgensen (Follo-Norway)was not bothered by the snow or mud and jumped out
to an early lead of ten seconds over Brink Kuckenbrod (Montana Velo-Msla).
Jorgensen, riding a mountain bike, was able to bunny-hop (or otherwise bash
his way) over half the obstacles on the course.
This was a big disadvantage for Kuckenbrod.
"I lost contact on the first lap because I had to dismount," he said, but
also gave credit to Jorgensen. "I got a thrashing by a guy with a set of
legs. I felt super but I had to wonder if that guy was in the next county."
Asked if he was going to race on Sunday, he cited a hunting commitment.
On Sunday the course was changed for more running, but that did little to
change the outcome. Jorgensen still grabbed an early lead, this time over
Dan Swanson (MSU-Bzmn), and finished with a two minute gap.
"Iíve never competed in cyclocross before," the twenty year old Norwegian
said, "it was dirty, but nice." Jorgensen hopes to turn pro sometime soon.
The next race in the series is in Missoula on October 28th. Contact Brink
Kuckenbrod at<EMAIL_ADDRESS>for details.
Open the attachment to see Brink Kuckenbrod in the cyclocross playground.
John Ross
Editor
Outdoorpulp
Here are the results:
Bozeman Cross Weekend
October 21, 2000
Mens'A
Petter Jorgensen 1 Follo-Norway
Brink Kuckenbrod 2 Montana Velo
Colin Miner 3
Peter Ford 4 MSU
Jon Burkhartsmeyer DNF Montana Velo
B's
Vegard Jevnesveen 1 BSF (Bozeman Ski Foundation)
Matt Hayes 2 YVCC
Deric Neiss 3 YVCC
Loren Jenkins DNF MSU
Masters 35+
John Weyhrich 1 5 Valley Velo
Jon Engen 2 GVBC
Dave Kelley 3 YVCC
Nick Coy 4 YVCC
Robert Hailkin 5 -
Masters 45+
Steve Muller 1 Flathead Velo
Kim Johnson 2 -
Richard Allen 3 5 Valley Velo
October 22, 2000
Men's A
Petter Jorgensen 1 Follo-Norway
Dan Swanson 2 MSU
Jim Rucker 3 MSU
Colin Miner 4 -
Dan Barry 5 YVCC
B's
John Behrans 1 Northern Rockies
Matt Hayes 2 YVCC
Deric Weiss 3 YVCC
Alan McCain 4 -
Masters 35+
Dave Kelley 1 YVCC
John Weyhrich 2 5 Valley Velo
Jon Engen 3 GVBC
Nick Coy 4 YVCC
Masters 45+
Kim Johnson 1 -
Steve Muller 2 Flathead Velo
Richard Allen 3 5 Valley Velo
Women's
Maria Kalnaes 1 MSU


This is an output of the current status of the chart. This info will be returned by default after calling the render() method - or optionally rendered on screen by setting the options.renderErrors = true


1. Lincoln and Reagan are former U.S.A. presidents.
2. Lincoln and Chevrolet are American car brands.
3. Angelina, her father Jon, and her partner Brad never played together in the same movie.
4. Jon was the host of The Daily Show from 1999 until 2015, but then Comedy Central replaced him with Noah.
5. The Red Devils were defeated by The Gunners in a packed Emirates.
6. Abu Dhabi is the capital of the Emirates. However, the most iconic building of the country, the Burj khalifa, is located in Dubai.
7. Adidas and Emirates are Madrid's main sponsors.
8. Madrid is the most populated city and capital of Spain, with Barcelona having the second largest population.
9. Rubio played for Barcelona before getting signed with the Minnesota Wolves.
10. Felix and Marzia are one of the hottest couples on YouTube.
11. Felix's second marriage was with the famous Mexican composer Lara.
12. Alexis, Merkel and Schauble discussed about the future of the Greek economy.
13. Greece defeats Portugal to claim Euro 2004 trophy.
14. Sandra played in the movie Speed with Keanu.
15. The popular comedy duo of Key and Peele stars in Keanu.
16. After the death of Steve, the former CEO of Apple, his commencement speech at Stanford was watched thousands of times.
17. Family Feud saw significantly improved ratings with Steve hosting the show.
18. The impact of Gödel's and Turing's breakthroughs in the 1930s is best understood against the background of the mathematical ambitions definitively expressed by Hilbert in the 1920s.
19. In 2006, the recipient of the Turing Prize was IBM's Frances Allen, and that was the first time ACM bestowed the highest distinction in computer science upon a woman.
20. The Tonight Show will not be the same if Jimmy leaves.
21. Prior to his Senate re-election run, Brock was among those considered to replace Rockefeller as Ford's running mate in the 1976 election.
22. Brock defeated Hunt on his UFC comeback.
23. Kurt and Krist are the founders of Nirvana.
24. In Forrest Gump, Kurt provided the voice over for Elvis.
25. UMM vehicles became known for their durability, especially when in the Paris-Dakar rally the team was able to finish with all the cars that started.
26. Umm was awarded honors by King Farouk.
27. Tiger was lost in the woods when he got divorced from Elin.
28. Tiger was drafted in the second round by the Maple Leafs in the 1974 NHL Amateur Draft.
29. Armstrong was the first man to walk on the Moon.
30. Armstrong was a great performer and influenced jazz like no other.
31. Blaugrana defeated Los Blancos last night in Camp Nou. Leo and Cristiano stole the show.
32. The Brazilians won the 2002 World Cup, with Ronaldo, Rivaldo and Ronaldinho playing forward.
33. On February 14, 2013, Oscar fatally shot Reeva in his Pretoria home.
34. Leo finally won an Oscar this year, for his tremendous performance in The Revenant.
35. Oscar wrote De Profundis while he was in prison.
36. Hunter and Stephanie are WWE's resident power-couple.
37. In 1983, after her physical recovery from the accident which killed her mother, Stephanie started an apprentice programme at Dior under the direction of head designer Marc Bohan.
38. JFK and Nixon took part in the first televised presidential debate in 1960.
39. Obama welcomed Merkel upon her arrival at JFK.
40. JFK was the most successful of three films Stone made about American presidents.
41. Despite featuring some of the most prominent musicians of their decade --- like Sinatra, Dylan, Joel, and Santana --- Columbia was acquired by Sony in the 1980s.
42. Three of the greatest guitarists started their career in a single band: Clapton, Beck, and Page.
43. Brin and Page founded Google.
44. Page plays in Nolan's Inception, alongside actors like DiCaprio, Hardy and Gordon-Levitt.
45. Hardy is best known for his essay, A Mathematician's Apology, in which he explains the essence of mathematics in layman's terms.
46. The Hardy Boys were created by American writer Edward Stratemeyer.
47. Becks and Posh got engaged in 1998.
48. Joanne met Daniel, Emma and Rupert on the set of Harry Potter.
49. DNA's molecular structure was identified by Watson and Crick in 1953.
50. Mars, Galaxy, and Bounty are all chocolate.
51. Mars, Migos, Future & more to perform at 2017 BET Awards.
52. Mars has co-written songs for Crashdïet and Machina.
53. Trump signed a law that makes manned missions to Mars NASA's main goal in the decades to come.
54. May invited Trump to Britain seven days after his inauguration when she became the first foreign leader to visit him in the White House.
55. Trump grew his channel into one of the most popular Hearthstone streams on the game streaming website Twitch.
56. Milky Way is a candy bar manufactured and distributed by Mars Confectionery.
57. The Milky Way is expected to collide with Andromeda in approximately 4.5 billion years.
58. It was quite a surprise for a lot of people that Donald won over Hillary. Many think that if Bernie had been in her place, things might have been different.
59. The Amazon, the Nile and the Yangtze are the longest rivers in the world.
60. Bezos is the chairman of Amazon.
61. Bezos was discovered by Thymios Karakatsanis. In his early days, he worked on stage with Vougiouklaki, and later on he played on successful TV series on Antenna and Mega.
62. According to calculations based on data from Credit Suisse and Forbes, Oxfam reported that only eight individuals (Gates, Ortega, Buffett, Slim, Bezos, Zuckerberg, Ellison and Bloomberg) own as much wealth as the poorest half of the world's population.
63. Slim signed with Dre's Aftermath Entertainment in the late 90s, and together they changed the landscape of rap music.
64. With various air forces, the Jaguar was used in numerous conflicts and military operations in Mauritania, Chad, Iraq, Bosnia, and Pakistan, as well as providing a ready nuclear delivery platform for Britain, France, and India throughout the latter half of the Cold War and beyond.
65. Jaguars can be found in the Americas, their range extending from the Southwestern United States and Mexico across much of Central America and south to Paraguay and northern Argentina.
66. Jaguar has been owned by the Indian company Tata Motors since 2008.
67. Margot and Will had worked together before Suicide Squad, so the chemistry was already there.
68. On August 23, 2015, Adult Swim offered Smith the opportunity to perform a song to commemorate the series finale of Aqua Teen Hunger Force.
69. Smith studied social philosophy at the University of Glasgow and at Balliol College, Oxford.
70. Grenoble has been twinned with Oxford since 1977.
71. Wiles proved the last of many conjectures written by Fermat in the margins of Arithmetica.
72. Bosch and Sharp are both home appliances producing companies.
73. Sebastian reigns supreme in Suzuka.
74. Floyd defeated Manny at the MGM Arena in Las Vegas, Nevada.
75. Jennifer, Courteney, Lisa, Matt, Matthew and David followed separate career paths after the finale of Friends.
76. The list of Victoria's Secret angels includes Adriana, Alessandra, Candice, Lily and Jasmine.
77. Zayn split from 1D in March 2015 and signed a solo recording contract with RCA.
78. Last night's NXT featured a match between Zayn and Corey.
79. Frank and Pepys are famous diarists.
80. Hearthstone poses a serious threat to Magic Online, mainly because of its polished interface.
81. Nike and Adidas are sportswear manufacturers.
82. Since 1884, Nike has been prominently displayed at the Louvre.
83. Elon is the CEO of Tesla Motors.
84. A common argument is about who contributed more to science: Tesla or Edison.
85. Socrates was a philosopher who lived in Athens.
86. Sokratis has played for AEK, Milan, Werder and Dortmund.
87. Cameron's first big screen appearance was on The Mask.
88. Cameron served as prime minister of the UK from 2010 to 2016.
89. Cameron is the director of Titanic.
90. Titanic started her maiden voyage from Southampton on the 10th of April, 1912.
91. Moore co-founded Intel.
92. Moore played the role of Simon Templar in The Saint between 1962 and 1969.
93. Moore starred in Striptease.
94. Can she be Moore perfect? Julianne, 56, looks ravishing as she shows off her svelte legs in chic mini-dress at Cannes Festival yacht party.
95. On May 20, 2013, parts of Moore and neighboring Newcastle and southern Oklahoma City were affected by a violent tornado.
96. Newcastle have won six FA Cups.
97. Valentino is racing for Yamaha.
98. Valentino, Gucci and Armani are Italian fashion labels.
99. An Idiot Abroad is a British travel documentary, with a comedic twist, starring Ricky, Karl and Stephen. It was broadcast on Sky 1.
100. When Jackson's Invincible was released on October 30, 2001, it was already being touted as the most expensive album ever made, with reports of Sony's price tag reaching $30 million.
101. Pulp Fiction was the first of several films in which Jackson performed under the direction of Tarantino.
102. Before being elected to the presidency, Jackson served in Congress and gained fame as a general in the United States Army.
103. Dallas is a mid-carder on Raw, while Wyatt, his brother, is more successful on Smackdown.
104. TI's headquarters are located in Dallas, Texas.
105. TI has collaborated with high-profile artists, like Rihanna and Timberlake.
106. L.B. Johnson occupied the White House from 1963 to 1969.
107. Johnson started from the WWE, but then chose to focus on his acting career.
108. Johnson played point guard for the Lakers.
109. Neutrogena and Aveeno are both subsidiaries of Johnson.
110. Fearless won Taylor multiple album of the year awards.
111. Taylor had the lead role in Mankiewicz's Cleopatra.
112. Taylor had a decorated career in the United States Army, before he became a president.
113. APC, a division of Schneider, produces quality power strips.
114. Schneider appears in Grown Ups. Sandler and Rock play in that movie as well.
115. Robben has been a key element of Oranje's offensive in the past few years.
116. Robben is located 6.9 km west of the coast of Bloubergstrand.
117. Even though he is mostly associated with Fender's products, Hendrix played several Gibson guitars throughout his career.
118. Gibson not only starred in Braveheart, but he also produced it and directed it.
119. In his professional boxing career debut, Tyson defeated his opponent in less than two minutes.
120. Tyson and his friend Nye, the science guy, are known for intriguing the public about scientific matters.
121. Brown is best known for his 2003 bestselling novel The Da Vinci Code.
122. On a single night—October 24, 1962—Brown recorded a live concert album at the Apollo Theater in Harlem.
123. In 2009, Brown received significant media attention after pleading guilty to felony assault of his then girlfriend, singer Rihanna.
124. Madagascar is a computer-animated franchise produced by DreamWorks Animation.
125. Madagascar is located in the Indian Ocean, off the coast of Southeast Africa.
126. Mercury is the only metallic element that is liquid at standard conditions for temperature and pressure.
127. Starting from the Sun and moving outwards, one sees Mercury, then Venus, then Earth.
128. Ford tried to bridge the gap between their main vehicle line and their luxurious Lincolns by launching Mercury, an entry-level premium car brand.
129. Mercury, who was the main vocalist in Queen, became known for his flamboyant personality and impressive vocal range.
130. Sun was acquired by Oracle on January 27, 2010 for 7.4 billion dollars.
131. Arizona's biggest attraction is the Grand Canyon, while Oklahoma is famous for the longest drivable stretch of Route 66.
132. Arizona and Oklahoma are two of the ships that sank in Pearl Harbor during the events of World War II.
133. Sanders is the longest serving independent politician in the history of the United States Congress.
134. Even after selling the KFC corporation, Sanders remained the company's symbol and brand ambassador.
135. Martin is a Puerto Rican pop singer, who is also known for his humanitarian work.
136. Martin is the creative genius behind Game of Thrones.
137. On October 14, 1964, Martin received the Nobel Peace Prize for combating racial inequality through nonviolent resistance.
138. James Bond always drives a Martin in his movies.
139. Martin and Leonardo have worked together in many films, like The Departed and Shutter Island.
140. Qatar CEO Akbar al Baker was attending a major IATA meeting in Cancun, when he was informed about the imminent crisis.
141. Qatar: UAE and Saudi Arabia step up pressure in diplomatic crisis.
142. Fotakis spent his early years playing for PAOK.
143. Fotakis, who received his diploma and PhD from the University of Patra, is currently an assistant professor at NTUA.
144. Dorociński won the Zbigniew Cybulski Award for his role in Pitbull.
145. On 4 February 2007, Pitbull played his first Primeira Liga match with Académica, against Naval.
146. In 2013, Pitbull released a diss track towards Lil Wayne called "Welcome 2 Dade County" shortly after Lil Wayne's rant on the Miami Heat.
147. Casablanca was part of the film colorization controversy of the 1980s, when a colorized version aired on the television network WTBS.
148. Casablanca is home to the Hassan II Mosque, designed by the French architect Michel Pinseau.
149. On 27 June 2007, Valencia netted Ecuador's first goal of their 2007 Copa América campaign, however they eventually lost the match 3–2 to Chile and finished the tournament bottom of their group.
150. Valencia is a successful club, considering the competitive level of La Liga.
151. Valencia is situated on the banks of the Turia, on the east coast of Iberia.
152. On November 9, 2007 an Iberia Airbus A340-600, registration EC-JOH, was badly damaged at Quito, Ecuador after sliding off the runway at Old Mariscal Sucre International Airport.
153. Carter plays for Racing 92 and played for New Zealand's national team, the All Blacks.
154. Carter discovered Tut's grave in the Kings Valley.
155. Collision Course is the fifth installment of the Ice Age film series.
156. In 2004, Carter and Linkin Park released Collision Course, a collaborative remix album.
157. In 1952, Carter began an association with the US Navy's fledgling nuclear submarine program, then led by Captain Hyman G. Rickover.
158. Venus and Serena are considered to be two of the top female tennis players.
159. Venus was directed by Michell and written by Kureishi.
160. Venus was discovered on the island of Milos in the Aegean.
161. Working alongside Roger Ailes, Dan Cooper became one of the co-founders of Fox News Channel in 1996.
162. The FBI maintained an active investigation for 45 years following the hijacking of a Northwest Orient Airlines Boeing 727 by a man called Dan Cooper.
163. Cooper received the Academy Award for Best Actor for his roles in Sergeant York and High Noon.
164. Cooper was one of the seven original astronauts in Project Mercury, the first manned USA space program.
165. In 2014, Cooper co-produced and starred as United States Navy SEAL sniper Chris Kyle in American Sniper—a biographical war drama directed by Clint Eastwood.
166. The Hollywood Vampires, consisting of Cooper, Depp and Perry, performed at the 58th Grammy Awards on February 15, 2016.
167. Perry got married to Brand in Rajasthan.
168. Washington is the capital of America.
169. Mount Rushmore features 60-foot sculptures of the heads of Washington, Jefferson, Roosevelt and Lincoln.
170. Washington played the role of a slave in Django.
171. For his role in Malcolm X, Washington won the New York Film Critics Circle Award for Best Actor and was nominated for an Academy Award for Best Actor.
172. On March 26, 1964, Malcolm X met Martin Luther King Jr. for the first and only time—and only long enough for photographs to be taken—in Washington D.C., as both men attended the Senate's debate on the Civil Rights Bill.
173. Lee, headquartered in Merriam, Kansas, is owned by VF Corp., the largest apparel company in the world.
174. Inside Man was one of Lee's most commercially successful pieces of work.
175. Fist of Fury is the first of only three movies in which Lee and Chan played together.
176. Thirty years after playing Francisco Scaramanga in The Man with the Golden Gun, Lee provided the voice of Scaramanga in the video game GoldenEye: Rogue Agent.
177. Lee is the director of W3C.
178. When Virginia declared its secession from the Union in April 1861, Lee chose to follow his home state, despite his personal desire for the country to remain intact and an offer of a senior Union command.
179. The Hulk was created by Lee and Kirby in the early sixties.
180. Hulk is currently signed with SIPG, and also plays for Brazil.
181. Hulk was removed from the WWE Network after his racist remarks were published.
182. In 2004 and 2005, Jane Seymour made six guest appearances in the WB Network series Smallville.
183. Jane Seymour was not educated as highly as King Henry's previous wives, Catherine of Aragon and Anne Boleyn.
184. One Hundred Years of Solitude, considered Márquez's magnum opus, remains widely acclaimed and is recognized as one of the most significant works in Latin American literature.
185. While Gomez's first three albums had been self-produced, the band decided to work with Tchad Blake as producer for their fourth record.
186. On 26 May 2009, Gomez was eventually transferred to Bayern for a Bundesliga record transfer fee, signing a four-year contract.
187. At 16 years of age, Gomez was signed to a recording contract with the Hollywood Records label, which had already signed both Cyrus and Lovato.
188. On September 20, 2009, Obama appeared on all major news programs except Fox, a snub partially in response to remarks about the president by commentators Glenn Beck and Sean Hannity, and Fox coverage of Obama's health-care proposal.
189. Fox began dating actor Austin Green in 2004, after meeting on the set of Hope & Faith.
190. Prior to Foreigner, Mick Jones was in the band Spooky Tooth.
191. Mick Jones' lack of punctuality played a major role in his dismissal from The Clash.
192. Brian Wilson has played in MLB for the Giants and the Dodgers.
193. After signing with Capitol Records in 1962, Brian Wilson wrote or co-wrote more than two dozen hits for the Beach Boys.
194. The Rio bridge, that crosses the Gulf of Corinth, was inaugurated on 7 August 2004, a week before the opening of the 2004 Summer Olympics in Athens.
195. Many tourists come to Rio to visit Christ the Redeemer and the world famous Copacabana beach.
196. Rio's theme song was performed by Taio Cruz.
197. In March 2007, Edge appeared alongside Randy Orton, John Cena, and Bobby Lashley on Deal or No Deal.
198. In 1976, at Mount Temple Comprehensive School Edge formed a band with his fellow students and elder brother Dik that would evolve into U2.
199. Chrome, Firefox and Edge are popular internet browsers.
200. In 2010, James Stewart received a Logie Award nomination for his role in Packed to the Rafters.
201. James Stewart had a noted military career and was a World War II and Vietnam War veteran.
202. After the much-publicized turmoil, Michelle Williams, alongside backup dancer Farrah Franklin, officially joined Destiny's Child in early 2000, replacing LeToya Luckett and LaTavia Roberson without notice.
203. Michelle Williams began dating Australian actor Heath Ledger, her Brokeback Mountain co-star, in 2004 after meeting on the set of the film.
204. For his artwork, Steve McQueen has received the Turner Prize, the highest award given to a British visual artist.
205. After Charles Manson incited the murder of five people, including Steve McQueen's friends Sharon Tate and Jay Sebring at Tate's home on August 9, 1969, it was reported McQueen was a potential target of the killers.
206. After Columbia dropped Kate Hudson, Angelica Cob-Baehler, then a publicity executive at the label, brought her demos to Virgin chairman Jason Flom.
207. In 2013, Kate Hudson began a partnership with online fashion retailer JustFab to launch her own line of workout clothes and active wear called Fabletics.
208. In August 2016, Woolworths Holdings announced that the David Jones headquarters will be moved from Sydney to Richmond, Victoria, owing to a combination of factors including rental lease fees and the market position for retail/fashion, as well as a lure from the Victorian Government.
209. In October 1990, a decade after his divorce from Angie, David Jones and Somali supermodel Iman were introduced by a mutual friend.
210. David Jones is best known for being a member of The Monkees.
211. Beethoven is a light-hearted family movie about a St. Bernard, in which Joseph Gordon-Levitt made his big screen debut.
212. In March 1787 Beethoven travelled to Vienna for the first time, in the hope of studying with Mozart.
213. After Cleopatra's reign, Ptolemaic Egypt became a province of the recently established Roman Empire.
214. Williams and Hugo make up the record production duo The Neptunes, producing soul, hip hop and R&B music.
215. After his family moved to Marin County, Williams began his career doing stand-up comedy shows in the San Francisco Bay Area in the mid-1970s. His first performance took place at the Holy City Zoo, a comedy club in San Francisco, where he worked his way up from tending bar to getting on stage.
216. Santa Clara coach Dick Davey realized the potential of Nash and recruited him for the college team.
217. Daskalakis, now a professor at MIT, gained international recognition for his work on Nash equilibriums.
218. Considering factors such as Bolt's position, acceleration and velocity in comparison with second-place-finisher Richard Thompson, the University of Oslo team estimated that Bolt could have finished in 9.55±0.04 s had he not slowed to celebrate before the finishing line.
219. Travolta and Cyrus are the main voice actors in Bolt.
220. Hamilton got his first Formula One win at Circuit Gilles Villeneuve in Montreal.
221. Born and raised in Detroit, Ross rose to fame as the lead singer of the vocal group The Supremes, which, during the 1960s, became Motown's most successful act, and is to this day the United States' most successful vocal group, as well as one of the world's best-selling girl groups of all time. In 1994, The Supremes were recognized with a star on the Hollywood Walk of Fame at 7060 Hollywood Blvd.
222. Ross dedicated the first episode of the second season of The Joy of Painting to Bill Alexander.
223. Ross previously says that if Birdman could burn good dudes like Khaled and Wayne, then he already knew how he felt about him.
224. The National Road reached Columbus from Baltimore in 1831, which complemented the city's new link to the Ohio and Erie Canal and facilitated a population boom.
225. Columbus was not the first European explorer to reach the Americas, having been preceded by the Viking expedition led by Leif Erikson in the 11th century, but his voyages led to the first lasting European contact with the Americas, inaugurating a period of European exploration, conquest, and colonization that lasted several centuries.
226. Aspirin was Bayer's first major product.
227. Bender plays as a midfielder for Bayer.
228. Bender was first mentioned as an important customs post in a commerce grant issued by the Moldavian voivode Alexander the Good to the merchants of Lviv on October 8, 1408.
229. In Futurama, Bender is Fry's best friend and roommate.
230. Avatar makes the short list of Nickelodeon series that were acclaimed by audiences of all ages and critics alike.
231. Following the film's success, Cameron signed with 20th Century Fox to produce three sequels, making Avatar the first of a planned tetralogy.
232. On 7 August 2008, Georgian forces began shelling the South Ossetian capital, Tskhinvali.
233. Georgia is the largest state entirely east of the Mississippi River in land area.
234. In an episode of the cartoon series, Michelangelo's pizza cravings annoyed the others so much that Master Splinter hypnotized him into refusing and denouncing pizza whenever the very word was mentioned.
235. Despite holding a low opinion of painting, Michelangelo created two of the most influential frescoes in the history of art when he decorated the ceiling and altar wall of the Sistine Chapel in Rome with artwork inspired from the Bible.
236. Olympus is located in the Troodos Mountains of Cyprus.
237. Olympus, the highest mountain in Greece, is located between the regional units of Pieria and Larissa, about 80 km (50 mi) southwest from Thessaloniki.
238. Woodford, a 30-year Olympus veteran and Olympus' president and chief operating officer since April 2011, had sought to probe financial irregularities and unexplained payments of hundreds of millions of dollars following his appointment as CEO.
239. Shortly after Hugo's election, ratings for freedom in Venezuela dropped according to political and human rights group Freedom House and Venezuela was rated "partly free".
240. Hugo was a Reichszeugmeisterei licensed supplier of uniforms to the SS and SA.
241. Hugo is buried in the Panthéon in Paris.
242. Based on Brian Selznick's book The Invention of Hugo Cabret, Hugo is about a boy who lives alone in the Gare Montparnasse railway station in Paris in the 1930s.
243. Hugo formed over the eastern Atlantic near the Cape Verde Islands on September 9, 1989. It moved thousands of miles across the Atlantic, rapidly strengthening to briefly attain category 5 hurricane strength on its journey. It later crossed over Guadeloupe and St. Croix on September 17 and 18 as a category 4 hurricane. Weakening slightly more, it passed over Puerto Rico as a strong category 3 hurricane. Further weakening occurred several hours after re-emerging into the Atlantic, becoming downgraded to a category 2 hurricane.
244. Sheeran made a great comeback and Atlantic will be releasing his new album this spring.
245. Monarch populations east of the Rocky Mountains migrate to the sanctuaries of the Mariposa Monarca Biosphere Reserve in Mexico and parts of Florida.
246. In the UK, 14 carriers including Easyjet, British Airways, Jet2, Monarch, Thomas Cook and Thomson flights will be affected by the new air travel regulations.
247. Goldberg appeared alongside Jackson and Bassett in the HBO documentary Unchained Memories.
248. Goldberg was one of the most dominant forces during his career in WCW.
249. His restaurant was awarded its third Michelin star in 2001, making Ramsay the first Scottish chef to achieve that feat.
250. Ramsay received the Chemistry Nobel Prize for his work on noble gases.
251. The concept of Ghostbusters was inspired by Dan Aykroyd's fascination with the paranormal. Aykroyd conceived it as a project for himself and his friend and fellow Saturday Night Live alumnus John Belushi.
252. Feig's Ghostbusters is considered a box office flop, having made an estimated $70 million loss.
253. At the age of 18, William Shakespeare married Anne Hathaway, with whom he had three children: Susanna, and twins Hamnet and Judith.
254. Her role as Fantine in Hooper's rendition of Les Miz earned Anne Hathaway widespread acclaim.
255. Olympiacos got a draw against Besiktas in Karaiskaki.
256. During the early stages of the Greek Uprising, Karaiskakis served in the militia in the Morea.
257. Monaco striker Radamel Falcao admits UCL game was 'difficult' for Dortmund.
258. Monaco is a principality governed under a form of constitutional monarchy, with Prince Albert II as head of state.
259. In 2017, Ferguson played a lead in Daniel Espinosa's sci-fi thriller Life.
260. Ferguson won 38 trophies with United.
261. Letter from United CEO Oscar Munoz calls flier 'Belligerent' and ignites anger from public.
262. Philadelphia is the Quaker State's largest city.
263. AEK is a Greek football club based in New Philadelphia.
264. Philadelphia was one of the first mainstream films to acknowledge AIDS, homosexuality, and homophobia. Tom Hanks was awarded the Best Actor Oscar for his performance in the film.
265. Diesel and Walker worked together in many Fast and Furious movies.
266. OTB is the parent company of multiple fashion brands, including Diesel and Marni.
267. Jordan became a member of the FIBA Hall of Fame in 2015.
268. John used to baptize people in the waters of Jordan.
269. Jordan is strategically located at the crossroads of Asia, Africa and Europe.
270. Former Top Gear host Richard Hammond has been flown to hospital after a crash while filming in Switzerland.
271. Adam West: TV Batman actor dies at 88.
272. Burton's Batman stars Nicholson and Keaton.
273. Ethiopia will run out of emergency food aid for 7.8 million people affected by drought at the end of this month, the UN has warned.
274. French voters are casting their ballots to pick their new MPs, a month after electing political outsider Emmanuel Macron as president.
275. Jose Mourinho has convinced Alvaro Morata to join Man Utd by ‘telling him he would be important’ after season as second string at Real Madrid.
276. Triantafyllopoulos is playing for Tripoli in Superleague.
277. Karyotakis was a Greek poet from Tripoli.
278. Tripoli's Bab al-Azizia served as the main base for the Libyan leader Gaddafi.
279. Beirut – Lebanese Prime Minister Saad Hariri’s visit to Tripoli on Thursday was significant seeing as it was the first of its kind to the northern city since his appointment to his position.
280. Hathaway and Blunt don flowing frocks to attend pal Chastain's wedding in Italy.
281. Blunt, who has been notoriously quiet about his private life said it was also Sheeran who really pushed him to open up about his family.
282. Beyond Pluto: NASA's next New Horizons target is its biggest mystery yet.
283. Pluto is Goofy's dog, who himself is an anthropomorphic dog, which has led to some confusion.
284. Pluto was distributed by Sidus Pictures.
285. Monroe stars in the film noir Niagara.
286. Niagara Falls are a massive tourist attraction on the border of the US and Canada.
287. As the fledgling army valued literacy in its officers, Monroe was commissioned with the rank of lieutenant, serving under Captain William Washington.
288. Cohen returned to music in 2001 with the release of Ten New Songs, which was a major hit in Canada and Europe.
289. Cohen tends to play in edgy and controversial movies like Borat and The Dictator.
290.  Parker is known for her leading role as Carrie Bradshaw on the HBO television series Sex and the City.
292. Parker plays for San Antonio and France.
293. In 2010 Clarke was cast as Daenerys Targaryen in the HBO medieval fantasy series Game of Thrones.
294. Clarke was a lifelong proponent of space travel. In 1934, while still a teenager, he joined the British Interplanetary Society.
295. The damage to the spacecraft made safe return from a lunar landing impossible, so Lead Flight Director Gene Kranz ordered an abort of the Apollo 13 mission.
296. In Howard's Apollo 13, Hanks plays the role of Lovell.
297. In 1995, Grant was arrested in Los Angeles with a sex worker, Divine Brown, for their ‘lewd conduct’ in a public place.
298. Uber chief Travis Kalanick may face bumpy ride.
299. EU nurse applicants drop by 96% since Brexit vote.
300. Putin critic Alexei Navalny held as thousands attend Russia protests.


The ‘Sea and Land Routes of southern Euboia’ (SESLR) project aims to provide a detailed study of regional developments in interconnectivity between ca. 4000 and 1 BC and in this manner make a critical contribution to the present discussion about Mediterranean interconnectivity. An important basis for this research has been the creation of a data base of all known settlements, important roads and routes, and maritime infrastructural elements, supplemented with new data provided by fresh field surveys and remote sensing research. From the beginning the intention was to make the project’s data base accessible to a larger group of potential users, including planners, heritage policymakers and archaeologists working for the state archaeological service. This Knowledge Hub is the result of this effort.
A short instruction on how to use the knowledge hub can be accessed here.


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Welcome to recipe book! A recipe book is a vegetarian food blog with a focus on easy recipes made with fresh, seasonal ingredients. A recipe book is one that you use daily and what we in our family call 'a living book' — a book that you use all the time, not just read once and discard on the shelf. Recipes are by nature derivative and meant to be shared - that is how they improve, are changed, how new ideas are formed.


Average of data over the previous hour (e.g., output at
12 UTC is the average over the period 11 UTC - 12 UTC).
| ID |
1. Surface Fluxes |
Unit |
Frequency |
| a |
incident solar (shortwave) radiation |
Watts / sq meter |
hourly |
| b |
reflected solar (shortwave) radiation |
Watts / sq meter |
hourly |
| c |
upward terrestrial (longwave) radiation |
Watts / sq meter |
hourly |
| d |
downward terrestrial (longwave) radiation |
Watts / sq meter |
hourly |
| e |
sensible heat flux |
Watts / sq meter |
hourly |
| f |
deep-soil heat flux |
Watts / sq meter |
hourly |
| g |
latent heat flux (evapotranspiration) |
Watts / sq meter |
hourly |
| h |
precipitation |
mm /month
| hourly |
| ID |
2. Top-of-atmosphere fluxes |
Unit |
Frequency |
| a |
net solar (shortwave) radiation |
Watts / sq meter |
hourly |
| b |
upward terrestrial (longwave) radiation |
Watts / sq meter |
hourly |
| ID |
3. Mass |
Unit |
Frequency |
| a |
surface pressure |
Pa |
hourly |
| b |
precipitable water |
m |
hourly |
| ID |
4. Vertical profiles at selected grids* |
Unit |
Frequency |
| a |
temperature |
K |
hourly |
| c |
specific humidity |
kg/kg |
hourly |
| d |
zonal (east-west) wind |
m/s |
hourly |
| e |
meridional (north-south) wind |
m/s |
hourly |
| f |
vertical velocity |
m/s |
hourly |
| g |
geopotential height |
m |
hourly |
| h |
pressure |
Pa |
hourly |
| ID |
5. Low-level Jet |
Level |
Frequency |
| a |
zonal wind (m/s) |
500 m AGL |
hourly |
| b |
meridional wind (m/s) |
500 m AGL |
hourly |
| ID |
6. Mixed-Layer Depth |
Unit |
Frequency |
| a |
mixed-layer depth |
m AGL |
hourly |