List all Reports for an Institute or Center for a particular year
All Annual Reports for NIMH for reporting year 2018
91 Annual Reports
Investigator-Initiated Project
1.
MH000889 (2018) Dysregulation of Protein Synthesis in Fragile X Syndrome and Other Developmental Disorders
Carolyn E Beebe, PhD
This work on human subjects was conducted under the protocol 06-M-0214, NCT00362843.
During the 2018 funding period, we addressed the following: 1) rCPS measured with the L-1-C-11leucine PET method in participants with FXS and healthy volunteers studied either under dexmedetomidine sedation or in ...
2.
MH001090 (2018) Studies of Central Nervous System Functional Anatomy
Miles Herkenham, PhD
Chronic psychosocial stress has been implicated in the etiology and progression of psychiatric disorders such as major depression and post-traumatic stress disorder (PTSD). In mice, we study the effects of psychosocial stress in a conflict paradigm that leads to behavioral alterations manifested as ...
3.
MH002032 (2018) Neural Coding of Visual Stimuli
Barry J Richmond, MD
Over the past half century, it has been shown that damage to the lateral inferior temporal cortex, areas TE and TEO, interferes with the ability of monkeys to integrate visual features into identifiable objects. Given this history, when we removed either TE or TEO, the architectonically defined infe ...
4.
MH002035 (2018) Functional Anatomy of Perceptual and Attentional Systems in the Primate Brain
Leslie G Ungerleider, PhD
A typical scene contains many different objects that compete for neural representation due to the limited processing capacity of the visual system. At the neural level, competition among multiple objects is evidenced by the mutual suppression of their visually evoked responses. The competition among ...
5.
MH002386 (2018) Chemical Coding of Neurotransmission
Lee E Eiden, PhD
The publications resulting from our activities of the past year are listed in the accompanying bibliography. They demonstrate our interest in specific signaling molecules that allow neurons to communicate with one another in highly specific ways that are experience-dependent, and allow behavioral pl ...
6.
MH002497 (2018) Functional Organization of the Cerebral Cortex and Basal Ganglia
Charles R Gerfen, PhD
Advances in molecular genetic techniques are revealing new details of the neuroanatomical organization of brain circuitry and the functional role of these circuits in behavior. Engineered viral vector constructs have been developed to label axonal projections of targeted neurons with unprecedented c ...
7.
MH002498 (2018) Roles of Oxytocin and Vasopressin in Brain
Walter Scott Young, MD, PhD
--We continued our studies of the CA2 region of the hippocampus where the Oxtr and Avpr1b are located. The CA2 area is an important, although relatively unexplored, component of the hippocampus. We are studying the role of various receptors and in the CA2 by crossing floxed receptor lines with Oxtr ...
8.
MH002537 (2018) Psychobiology and Treatment of Perimenopausal Mood Disorders
Peter J Schmidt, MD
This report includes work arising from the following clinical protocols: NCT00030147, NCT00060736, NCT00001231, and NCT00001322.
Our findings to date show that PMD is accompanied by a decreased QOL, decreased social adjustment and impaired role functioning comparable to depression occurring at ot ...
9.
MH002588 (2018) The Neural Foundations for Memory and Social Cognition In The Human Brain
Alex Martin, PhD
In the past decade there has been increasing interest in using functional neuroimaging (especially fMRI) to uncover the intrinsic, functional organization of the human brain. This is often accomplished by collecting data while subjects lie quietly in MRI machines (commonly referred to as resting-st ...
10.
MH002619 (2018) Neural Mechanisms of Motivation and Reward
Barry J Richmond, MD
Previous experiments from our group and others have shown that medial temporal lobe (MTL), orbital prefrontal cortex (OFC), and ventral striatum (VS) play important roles in the integration of visual and reward value information. Damage to any of those structures has an adverse effect on the ability ...
11.
MH002652 (2018) Imaging of Neuropsychiatric Disorders with Developmental and Genetic Mechanisms
Karen F Berman, MD
The core aim of this project is to elucidate the nature, molecular foundations, underlying neurochemistry, and clinical correlates of neural systems-level dysfunction in schizophrenia. The Clinical and Translational Neuroscience Branchs recent efforts have included studies examining pathophysiology ...
12.
MH002666 (2018) Evaluation and Treatment of Obsessive Compulsive and Related Disorders
Susan Elizabeth Swedo, MD
Obsessive-compulsive disorder (OCD) affects 1-2% of children and adolescents, causing significant distress and impairments from the unrelenting obsessional thoughts and compulsive behaviors. Approximately 1/4 of children with OCD report an abrupt, dramatic onset of their symptoms. When these sympto ...
13.
MH002717 (2018) Neuroimaging of Brain Circuits and Molecular Mechanisms in Normal Cognition
Karen F Berman, MD
The Clinical and Translational Neuroscience Branch continues to make advances on several fronts in order to delineate the neurochemical, neurogenetic, and neuropsychological contributions to neural systems function and development relevant to mental illness. We have devoted extensive efforts toward ...
14.
MH002736 (2018) Neural Substrates of Stimulus Recognition and Association Memory
Elisabeth Adams Murray, PhD
The prevailing model of amnesia holds that it depends on damage to a group of loosely related structures, collectively called the medial temporal lobe (MTL). One influential theory holds that these areas work together as a single functional unit. According to this theory, the structures in the MTL s ...
15.
MH002768 (2018) Subcellular Compartmentalization of Neuronal Gene Expression
Barry Bernard Kaplan, PhD
Although once highly controversial, it is now well- established that there exists a diverse population of mRNAs and non-coding microRNAs in the distal structural/functional domains of the neuron which include the dendrite, axon, and presynaptic nerve terminal. It has also become well- accepted that ...
16.
MH002781 (2018) fMRI Studies Of Pediatric Mood And Anxiety Disorders
Daniel Pine, MD
This work is conducted under protocol 01-M-0192, NCT00018057.
We are using functional magnetic resonance imaging (fMRI) to examine neurocognitive correlates of pediatric anxiety disorders. Through ongoing collaborative studies, we also have increasingly compared findings in these syndromes with fin ...
17.
MH002782 (2018) fMRI Studies Of Risk For Mood And Anxiety Disorders In Children
Daniel Pine, MD
This work is conducted under protocol 03-M-0186, NCT00060775.
In this project, our group is examining biological aspects of risk for mood and anxiety disorders in children. Such work has major public impact. By identifying biological risks in children, information on novel treatments and preventati ...
18.
MH002783 (2018) Functional MRI Method Development
Peter A Bandettini, BS, PhD
Protocol number 93-M-0170, NCT00001360
The Section on Functional Imaging Methods (SFIM) has advanced functional MRI (fMRI) methodology through development of novel paradigms, acquisition methods, and processing methods Our work over the past year can be grouped into the following categories: Layer ...
19.
MH002784 (2018) Neurogenesis in the Adult Brain
Heather A Cameron, PhD
This project focuses on the interactions between experience and adult neurogenesis in the hippocampal region of the brain. We are interested in understanding how experiences, including positive and stressful experiences, regulate adult neurogenesis and how the new neurons alter responses in these si ...
20.
MH002786 (2018) The Pathophysiology and Treatment of Children with Severe Irritability ZIA MH002786-17
Ellen Leibenluft, MD
Given concerns about the appropriate diagnosis for children with chronic, severe irritability, we defined severe mood dysregulation(SMD)to capture youth with extremely severe irritability and symptoms of hyperarousal. Our SMD phenotype formed the basis for the new pediatric diagnosis of mood dysregu ...
21.
MH002793 (2018) PET Radiopharmaceutical Sciences
Victor W Pike, PhD
The Molecular Imaging Branch (MIB) aims to exploit positron emission tomography (PET) as a radiotracer imaging technique for investigating neuropsychiatric disorders, such as autism, depression, addiction, schizophrenia, and Alzheimer's Disease (AD). Fundamental to this mission is the development of ...
22.
MH002795 (2018) Translational Evaluation of PET Radiotracers
Robert Innis, MD
For several years, we have focused on developing much-needed effective, sensitive, and reliable radioligands capable of imaging neuroinflammation. These efforts included the development of now widely-used radioligands for translocator protein (TSPO), as described in past annual reports. Building on ...
23.
MH002797 (2018) Neuronal Avalanches in the Neocortex
Dietmar Plenz, PhD
1. Using an animal model of schizophrenia, we demonstrate for the first time that this animal model displays specific deviations from ongoing avalanche dynamics that differs from a typical imbalance of excitation/inhibition in cortex.
Altered avalanche dynamics in a developmental NMDAR hypofunctio ...
24.
MH002798 (2018) The Psychophysiology of Fear and Anxiety
Christian Grillon, PhD
This project identifies core psychological and behavioral processes and their underlying neural mechanisms related to anxiety and anxiety disorders. Using a high-spatial resolution 7 Tesla scanner, we map the functional connectivity of small structures implicated in fear and anxiety, including the c ...
25.
MH002800 (2018) Identifying Neural Substrates of Behavior in Drosophila Melanogaster
Benjamin H White, PhD
Insect ecdysis sequences represent a simple, robust, and tractable model for studying the neuromodulatory mechanisms that govern behavior. Because initiation of an ecdysis sequence involves a profound shift in behavioral priorities, study of these sequences offers the opportunity to understand the n ...
26.
MH002803 (2018) Magnetic Resonance Spectroscopy and Imaging Studies of Brain Functions
Jun Shen, PhD
The goal of this research is to develop advanced magnetic resonance spectroscopy (MRS) and imaging techniques and to apply them and other complementary methods to studying brain metabolism, neurotransmission, and enzyme activity. MRS allows measurement of the neurotransmission of glutamate and GABA ...
27.
MH002804 (2018) Family Study of Affective and Anxiety Spectrum Disorders
Kathleen R Merikangas, PhD
The major aims of this project have been accomplished through the establishment of a large community-based family study of adult probands who participate in comprehensive clinical and biologic assessments followed by comparable evaluations of their adult and child relatives. Recruitment of probands ...
28.
MH002810 (2018) Functional Genomics of Bipolar Disorder
Francis Joseph McMahon, MD
NCT00001174
In order to better interpret the impact of genetic variation on the brain biology of bipolar disorder, we are pursuing a variety of functional genomics studies, including brain imaging, RNA-sequencing in post-mortem brain tissue, and cellular phenotyping of neurons derived from induce ...
29.
MH002838 (2018) Neurophysiology of Visual Perception
David A Leopold, PhD
Humans use their vision in ways that other animals do not. For example, we learn to read very subtle facial expressions that can tell us whether a person is lying, angry, embarrassed, skeptical, or in a hurry. We also have an unmatched capacity to use vision to steer our hands so that we can, for ...
30.
MH002843 (2018) Identification of Genes Involved in Major Mood Disorders
Francis Joseph McMahon, MD
NCT00001174
Starting in 1993, in collaboration with 10 academic centers across the US, we recruited a large sample of over 3,000 individuals with bipolar or other mood disorders. All participants did a diagnostic interview and provided a blood sample for DNA analysis. DNA and clinical data are av ...
31.
MH002844 (2018) Genetic Determinants of Antidepressant Response
Francis Joseph McMahon, MD
NCT00088699
Strong evidence from family and twin studies demonstrates that major depressive disorder (MDD) is heritable, yet there has been limited progress in identifying the actual genes involved. A separate, perhaps overlapping set of genes is expected to play a role in individual variation in ...
32.
MH002852 (2018) Clinical Evaluation of PET Radiotracers
Robert Innis, MD
Examples of progress made during the prior year are summarized below.
1. Replication of the finding that PET radioligand binding to TSPO, a putative biomarker of inflammation, is increased during major depressive episodes
Translocator protein 18 kDa (TSPO), a potential biomarker of neuroinflam ...
33.
MH002857 (2018) Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect
Carlos Alberto Zarate, MD
Our results indicate that the glutamatergic system is involved in the mechanism of action of rapid antidepressant response. In addition, this system may be a feasible target for developing treatments that have rapid and robust efficacy in individuals who have treatment-resistant depression and suici ...
34.
MH002863 (2018) Multimodal Neuroimaging of Gene-Brain Relationships in Williams Syndrome
Karen F Berman, MD
The Clinical and Translational Neuroscience Branch continues to work toward discovery of novel genetic contributions to brain structure, function, and clinically relevant behavior and cognition, through a series of ongoing multimodal neuroimaging studies of individuals with copy number variation in ...
35.
MH002865 (2018) Reproductive Endocrine Related Mood Disorders-Differential Sensitivity
Peter J Schmidt, MD
This report includes work arising from the following clinical protocols: NCT00005011, NCT00056901, NCT00059228, NCT00082043, NCT00100360, NCT00001177, NCT00001259, and NCT00001481.
The linkage between the onset of symptoms and the luteal phase of the menstrual cycle suggests a role for ovarian ster ...
36.
MH002874 (2018) The Neuroregulatory Effects of Gonadal Steroids in Humans
Peter J Schmidt, MD
This report includes work arising from the following clinical protocols: NCT00026832, NCT00100360, NCT00001177, and NCT00001322.
Previous studies have identified the presence of abnormalities in resting state activity and reward processing in mood disorders. Indeed, altered resting state function r ...
37.
MH002881 (2018) Molecular Mechanisms of Synapse Development and Plasticity
Zheng Li, PhD
1. The molecular mechanism underlying long-term synaptic depression. The strength of synaptic transmission can change through synaptic plasticity. Long-lasting forms of synaptic plasticity (such as long-term potentiation and long-term depression of synaptic transmission) are important cellular mecha ...
38.
MH002882 (2018) Characterizing the Function of miRNAs in Neural Development, Synaptic Plasticity and Schizophrenia.
Zheng Li, PhD
miRNAs have been implicated in schizophrenia. Mutations in genes encoding miRNAs or components in the miRNA biogenesis machinery are associated with increased risk for schizophrenia. It is hypothesized that miRNA expression is aberrant in schizophrenia. Using microarray and quantitative PCR, several ...
39.
MH002886 (2018) Neural mechanisms of reward processing and emotion
Elisabeth Adams Murray, PhD
Measures of the autonomic nervous system are often used to infer mood or temporally extended affective states in humans, yet little is known about this relationship in other animals. Studies in animals have predominantly assessed instantaneous and short-lived behavioral and neural responses to eithe ...
40.
MH002887 (2018) Neural Substrates of Reward Processing and Emotion
Elisabeth Adams Murray, PhD
Neurons in the OFC encode the sensory properties, magnitude and subjective value of expected and received outcomes, typically foods and fluids. For this reason, OFC has been studied for it role in learning and reward-based choice. The estimated values of choices, and therefore decision making based ...
41.
MH002893 (2018) Learning and plasticity in the human brain
Christopher Ian Baker, PhD
The primary goals of this research are i) to establish how learning impacts the structure and function of the brain, and ii) to determine how learning can be modulated by factors such as feedback (positive or negative). Over the past year we have focused equally on both of these goals.
1) Impact ...
42.
MH002896 (2018) The Neural Basis of Functional MRI Responses
David A Leopold, PhD
It is now commonplace to see maps of human brain activity created using functional magnetic resonance imaging (fMRI). This method has greatly advanced our understanding of how activity in the brain corresponds to particular percepts, actions, and thoughts. More recently, even the spontaneous activi ...
43.
MH002897 (2018) Molecular and Cellular Mechanisms of Experience-Dependent Cortical Processing
Kuan Hong Wang, PhD
Our brain can be considered as a type of information processing system like a computer, where input signals need to be first detected and properly represented, then integrated with goals for decision-making and output control. Executive control of goal-directed behaviors is frequently disrupted in ...
44.
MH002898 (2018) Social Processing and Neural Plasticity
David A Leopold, PhD
The first face and body-selective neurons in the brain were discovered nearly 50 years ago. Nonetheless, it is only recently that studying social signals in the primate brain has become popular, in part because early researchers were skeptical that the brain would explicitly respond to, or represent ...
45.
MH002909 (2018) Object, face, body and scene representations in the human brain
Christopher Ian Baker, PhD
The goal of this research is to understand how we see what we see: how does the brain analyze the light falling on the retina of the eye to reveal a world full of objects, people and things?
During the past year we have focused on the perception of complex visual stimuli, in particular real-worl ...
46.
MH002917 (2018) Office of the Scientific Director
Susan G Amara, PhD
The NIMH Division of Intramural Research Programs' (IRP) scientists conduct research ranging from studies into the mechanisms of normal brain function at the behavioral, systems, cellular, and molecular levels, to clinical investigations into the diagnosis, treatment and prevention of mental illness ...
47.
MH002918 (2018) Functional Anatomy of Face Processing in the Primate Brain
Leslie G Ungerleider, PhD
Lesions of inferior temporal (IT) cortex in humans can result in the syndrome termed prosopagnosia, an inability to recognize familiar faces. Single-cell recordings from IT cortex of monkeys have revealed the existence of neurons that are selectively activated by visual images of faces. Additionally ...
48.
MH002920 (2018) The Cognitive Neuroscience of Autism Spectrum Disorders
Alex Martin, PhD
This past year we have continued to evaluate the neural characteristics and associated behavioral consequences of Autism Spectrum Disorders (ASD).
Prevailing theories suggest that ASD results from impaired brain communication due to aberrant timing or coordination of neuronal firing patterns (im ...
49.
MH002922 (2018) Psychiatry Consultation Liaison Service Research
Maryland Pao, MD
The main areas of OCD research are:
Suicide Risk in the Medical Setting
Suicide is an international public health threat. In the U.S., it is the 2nd leading cause of death for youth and the 10th leading cause of death for adults. The Director of NIMH, Dr. Joshua Gordon has made suicide preventio ...
50.
MH002927 (2018) Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders
Carlos Alberto Zarate, MD
This Report involves work collected under protocols 01-M-0254 (NCT00024635 ); 08-M-0196 (NCT00759395); 08-M-0150 (NCT00697268); 14-M-0085 (NCT02122562); 07-M-0021 (NCT00397111); 14-M-0041 (NCT02049385); and 07-M-0152 (NCT00472576), 09-M-N230; 15-M-0151 (NCT 02484456), 15-M-0188 (NCT02543983).
Res ...
51.
MH002928 (2018) Frontal Striatal Systems and Dopamine in Normal and Pathological Behavior
Bruno B Averbeck
Our lab uses a combination of neurophysiology, pharmacology and imaging to understand how a set of brain areas composed of the amygdala, ventral-striatum, prefrontal cortical areas and dopamine underlie learning. We specifically study learning to predict whether choices tend to lead to good or bad ...
52.
MH002933 (2018) Endocrine and Neurobiologic Events Accompanying Puberty
Peter J Schmidt, MD
This report includes work arising from the following clinical protocol: NCT01434368.
We have recruited approximately half of the proposed sample, and several of the children in the original 12-13-year-old cohort have completed the study through to their 18th birthday. To date we have studied 57 pre ...
53.
MH002935 (2018) Mathematical and Statistical Analysis Techniques for in Vivo Imaging Studies
Carolyn E Beebe, PhD
In the current year we have completed and published our refined data analysis methods for estimation of rates of cerebral protein synthesis (rCPS) with L-1-C-11leucine and PET. We also completed validation and publication of the impact of a simplified patient scanning protocol.
(1) Refinement of ...
54.
MH002936 (2018) Cerebral Protein Synthesis During Sleep and Memory Consolidation
Carolyn E Beebe, PhD
During the FY 2018 funding period, we addressed the following:
In collaboration with our colleagues from the Walter Reed Army Institute of Research (T Balkin) and NINDS (D. Picchioni), we applied the L-1-C-11leucine positron emission tomography (PET) method to measure rCPS in human subjects durin ...
55.
MH002942 (2018) Multimodal Imaging: Genetic and Environmental Effects in Neuropsychiatry
Karen F Berman, MD
In order to better understand how schizophrenia risk genetics operate at the cognitive and neural systems level, our recent work under this project has focused on understanding the biological correlates of both polygenic illness risk and gene-by-environment interactions. Ongoing studies in these are ...
56.
MH002946 (2018) Structure, Function and Pharmacology of Neurotransmitter Reuptake Systems
Susan G Amara, PhD
Our laboratory has shown that amphetamines trigger the internalization of the dopamine transporter (DAT) by a series of intracellular events that are distinct from the generally established actions of amphetamines to inhibit DA uptake or to increase DA efflux. We have found that when applied to cell ...
57.
MH002948 (2018) Cerebral Protein Synthesis as a Measure of Degenerative Changes in a Transgenic Rat Model of Alzheimer's Disease
Carolyn E Beebe, PhD
During the 2018 funding period, we completed analysis of studies of rCPS with the autoradiographic L-1-C-14leucine method in cohorts of WT and TgF344-AD at six, 14, and 18 months of age. In these animals, we also measured activity by means of open field behavior, memory by means of the T-maze, olfac ...
58.
MH002949 (2018) Developmental Neurogenomics Unit
Armin Raznahan
This work is conducted under protocol 89-M-0006 (NCT00001246), and falls into two broad research themes:
Theme 1: Studies of behavior and brain organization in typically-developing groups
Work in this theme uses large-scale neuroimaging studies in health to advance our basic understanding of h ...
59.
MH002950 (2018) Dissecting the stress circuits of the paraventricular nucleus of the thalamus
Mario Alexander Penzo
During this fiscal year our group identified a major neuronal subpopulation of the PVT that expresses dopamine D2 receptors (D2R+) and whose excitability is significantly enhanced following stress. Importantly, we uncovered that this increase in excitability is the result of a stress-induced reducti ...
60.
MH002951 (2018) Neural Circuits Underlying the Control of Executive and Emotional Behavior
Yogita Chudasama, PhD
In recent years, the work in my lab and that of other investigators has revealed that so-called prefrontal function, in fact, involves a broad network of areas including not only the prefrontal cortex but also the hippocampus, basal ganglia, and certain thalamic nuclei. These structures are anatomic ...
61.
MH002953 (2018) Population-Based Epidemiologic Research
Kathleen R Merikangas, PhD
During the past year, we have used NCS-A data to investigate the lifetime prevalence of mental disorder and mental health service use among adolescents by immigrant generation and racial/ethnic minority status, and found that some groups of adolescents are at greater risk for mental disorder than th ...
62.
MH002954 (2018) Motor Activity Research Consortium for Health (mMarch)
Kathleen R Merikangas, PhD
There is growing interest in studying the environmental, biologic and genetic correlates of the components of motor activity as well as the relationships between motor activity with sleep, exercise, mood, and cognitive functioning. Aggregation of the findings across these studies is complicated by t ...
63.
MH002955 (2018) Non-invasive Neuromodulation Unit (NNU)
Sarah Hollingsworth Lisanby
Work was conducted under clinical protocols NCT03065335 and NCT03289923.
Major accomplishments for the NNU were the recruitment of additional staff, acquiring research data from our first subjects in our collaboration with the Experimental Therapeutics and Pathophysiology Branch (ETPB), launching o ...
64.
MH002956 (2018) Patterns of neuronal activity underlying behavioral decisions
Mark H Histed, PhD
In one project, we are examining how particular sets of neurons are chosen by the brain to guide decisions. Whenever humans or animals see sensory stimuli, many brain areas are activated. We hypothesize that there are particular representations particular patterns that are created in each brain area ...
65.
MH002957 (2018) Mood, Brain, and Development Unit
Argyrios Stringaris
Under NCT03388606, we have:
1. Screened: 449 potential MDD patients, 120 HVs
2. Enrolled: 80 MDD patients, 70 HVs (including in other protocols)
3. Scanned: 255 MDD and HVs in total, including repeated scans on same individual as part of follow-up.
4. Increased inpatient activity: this protocol ...
66.
MH002958 (2018) Unit on Neurons, Circuits and Behavior
Arash Afraz, MD, PhD
While our permanent lab space is not ready yet, during the past year we have set up a physiology lab in our temporary space, and two post docs have joined the lab (one has arrived, the other one will join soon).
We have started two projects in the temporary space. One of them involves perturbat ...
67.
MH002959 (2018) Circuit mechanisms underlying cortical communications
Soohyun Lee, PhD
Summary
In order to understand the principles of long-range connectivity in cortical communication, our efforts have focused on the following two projects.
Project 1: Functional connectivity of diverse long-range inputs to the primary somatosensory cortex. To achieve a mechanistic understanding ...
68.
MH002964 (2018) Section on Light and Circadian Rhythms
Samer Saleh Hattar
Research projects, Fiscal Year 2018, can be divided into four major areas listed below:
1- The Development and the role of the SCN in regulating several output functions
The suprachiasmatic nucleus (SCN) is believed to influence circadian rhythms primarily by direct efferent connections with dow ...
69.
MH002966 (2018) Multiple Scales of Stimulus Representation in the Human Brain
Elisha Prem Merriam
During the past year, we have focused on 1) characterizing the representation of stimulus features in primary visual cortex and 2) studying how these representations interact with endogenous brain states, such as spatial attention and arousal.
1) Characterizing stimulus representations in human ...
70.
MH002967 (2018) Computation by recurrent circuits of the cerebral cortex
Mark H Histed, PhD
In one project, we reported results that shed light on input-output transformations in cortical networks. We recorded spiking responses from visual cortex (V1) of awake mice of either sex while pairing sensory stimuli with optogenetic perturbation of excitatory and parvalbumin-positive inhibitory n ...
Scientific Core
1.
MH002884 (2018) Functional MRI Core Facility
Peter A Bandettini, BS, PhD
Summary
Protocol number 93-M-0170, NCT00001360
Space Utilization:
The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, 3TD, and 7T MRI scanners located with ...
2.
MH002888 (2018) Scientific and Statistical Computing Core
Robert Cox, PhD
The principal mission of the Core is to help NIH researchers with analyses of their fMRI (brain activation mapping) and structural MRI (brain anatomy) data. Along the way, we also help non-NIH investigators, mostly in the USA but also some abroad. Several levels of help are provided, from short-term ...
3.
MH002889 (2018) NIMH MEG Core Facility
Allison Carol Nugent, PhD
Hardware:
The MEG Core operates a state-of-the-art 275 channel MEG system (CTF MEG).  In November of 2017, the electronics controlling the MEG system was completely replaced by new equipment, r ...
4.
MH002894 (2018) Magnetic Resonance Spectroscopy Core Facility
Jun Shen, PhD
As a noninvasive method for measuring the concentration and distribution of chemicals in the living brain, MRS is an important tool for studying brain function and disorders. However, acquiring robust measurement of MRS signals requires a sophisticated study design and the successful development, im ...
5.
MH002899 (2018) Neurophysiology Imaging Facility Core: Functional and Structural MRI
David A Leopold, PhD
As the technology of magnetic resonance imaging (MRI) improves, and as scanners become more prevalent across the world, both structural and functional imaging have become a central part of brain research in nonhuman primates. This is because having a precise 3D map of structures or activity in the b ...
6.
MH002901 (2018) Transgenic Resources for Neuroscience Research
James M Pickel, AB, PhD
The NIMH transgenic core facility has several major functions: 1) to produce transgenic research animals for neuroscience research, 2) to support research with associated techniques in genetic research in neuroscience, 3) to develop new transgenic techniques and model systems and 4) to engage in col ...
7.
MH002903 (2018) Procurement and Characterization of Postmortem Brain Tissue
Barbara K Lipska, PhD
Currently, the HBCC resources include brains from individuals with the following diagnoses (numbers of subjects listed in parentheses): Bipolar disorder (153), Non-psychiatric controls (307), Schizophrenia and schizoaffective disorder (202), Substance Abuse (59), Major depressive disorder (237), Oth ...
8.
MH002911 (2018) NIMH Instrumentation Core Facility
George Raphael Dold, MME, BSEE
This past year, our Section had the unique opportunity to support the research of various Labs & Sections within NIMH, NINDS, NICHD, and NCCIH. During the past twelve months, investigators from these labs and branches requested 467 formal projects from our staff. Each of these requests was documente ...
9.
MH002952 (2018) Rodent Behavioral Core: The Analysis of Behavior
Yogita Chudasama, PhD
Behavioral neuroscience links systems-level circuitry to behavior, cognition and emotion and is thus critical for understanding the afflictions that affect neuropsychiatric patients. Linking cognitive changes in a behaving rat or mouse to targeted manipulations of neural circuitry requires the conve ...
10.
MH002960 (2018) Data Science and Sharing Team
Adam G Thomas, PhD
This is the second annual report for the Data Science and Sharing Team (DSST), our first year with our full staff in place. 2018 also marked the arrival of Francisco Pereira, the director of our sister group, the Machine Learning Team. Follows is a list of our noteworthy projects.
Intramural Data ...
11.
MH002961 (2018) Neurodevelopmental and Behavioral Phenotyping
Audrey E Thurm, PhD
The Neurodevelopmental and Behavioral Phenotyping Service conducts over 200 neurodevelopmental assessments yearly, collecting and analyzying data from a variety of rare genetic disorders associated with Intellectual Disability and Autism Spectrum Disorder. Much of the data analyzed has been collect ...
12.
MH002962 (2018) Sleep and Neurodevelopment Service
Ashura Buckley
This past year the Sleep and Neurodevelopmental Service scheduled over 150 overnight sleep studies ordered by eleven different institutes, more than half for pediatric patients. We have collected sleep data on several distinct cohorts including children with childhood onset schizophrenia, obsessive ...
13.
MH002963 (2018) Systems Neuroscience Imaging Resource
Theodore B Usdin, MD, PhD
This is the second year of operation of the Systems Neuroscience Imaging Resource (SNIR). Much of the focus has been on equipment acquisition and procedure development.
A Zeiss AxioscanZ1 slide scanning microscope is now in its second year of operation. This is a high quality widefield microscope ...
14.
MH002965 (2018) Statistical Genomics and Data Analysis Core
Yin Yao Shugart, PhD
In FY2018, we completed 30 consulting projects including a variety of data analysis, statistical modeling for neuronal spiking, genomic mechanism investigation of psychiatric disorders including obsessive compulsive disorder and schizophrenia. Below we highlight two service projects which led to a p ...
15.
MH002968 (2018) Machine Learning Team
Francisco Pereira
This is the first annual report for the Machine Learning Team. We have only been fully operational since January of 2018, when Francisco Pereira was hired. Charles Zheng and Patrick McClure were hired late in 2017, and worked within the Data Science and Sharing Team (DSST) until January. In 2018, th ...
Clinical Support Services
1.
MH002912 (2018) Office of the Clinical Director
Maryland Pao, MD
CLINICAL RESEARCH SUPPORT SERVICES: A central mission of the OCD is to ensure that research participants receive the highest quality clinical care. The OCD is responsible for oversight of all clinical aspects of the NIMH Intramural Research Program (NIMH IRP).
HUMAN SUBJECT PROTECTIONS: The mis ...
Clinical Training
1.
MH002939 (2018) Office of the Clinical Director-Psychiatry Clinical Research Training
Maryland Pao, MD
Clinical Fellowship Programs:
During FY18, there were nine NIMH IRP residents/fellows. The academic year generally starts in July so this number includes new, current and departing trainees in our programs. Of the nine trainees, three entered through our PGY-4 ACGME accredited psychiatry residency ...
Animal Research Infrastructure
1.
MH002924 (2018) Veterinary Medicine Research Branch
James Raber, DVM, PhD
The NIMH Veterinary Medicine Research Branch (VMRB) has successfully provided veterinary medical, husbandry and research support to over twenty-seven (27) principal investigators in the NIMH IRP with over fifty-five (55) active animal study protocols. In addition, the Branch has provided training an ...
New Space Activation & Commissioning
1.
MH002947 (2018) NIMH Space Activation, Maintenance, and Improvement
Susan G Amara, PhD
NIMH intramural scientists conduct research ranging from studies into the mechanisms of normal brain function at the behavioral, systems, cellular, and molecular levels, to clinical investigations into the diagnosis, treatment and prevention of mental illness. Researchers study conditions in adults ...
Education and Outreach
1.
MH002916 (2018) Office of Fellowship Training
Janet Elizabeth Clark
In fiscal year 2018 (FY18) the OFT processed personnel cases for approximately 693 fellows including 190 Special Volunteers. The OFT provided training to all NIMH IRP administrative staff on the processing of trainee personnel cases. The OFT provided 13 faculty with 17 Predoc IRTA slots including tr ...
Technology Transfer
1.
MH002925 (2018) Office of Technology Transfer
Jennifer S Wong
The Office of Technology Transfer Office (OTT) negotiates Material Transfer Agreements, Cooperative Research Development Agreements (CRADA), Licenses, Collaboration Agreements, Confidential Disclosure Agreements, and Clinical Trial Agreements. OTT also provides guidance and assistance to NIMH resear ...


H.B. Woodrose & Cannabis
My best friend, the initiator in my involvement in the journeys of psychedelia with my first breath of cannabis, traveled two hours just to surprise me with a bag of fifteen Hawaiian Baby Woodrose seeds of medium-quality. At first I was skeptical, of course, and chose to experiment with the salvia divinorum first. It was low grade, and I experienced nothing from it. The seeds were ground into a powder with a mortar and pestle, and I drank it with the salvia tea/coffee mixture I had made. The salvia did not effect the experience.
The experience was at first as if I were rising and rising, the chakra points flowing upward from the base of my spine and filling my temporal lobe with a euphorant rise that could be described as an inflation of my head with nitrogen and letting it float just above my body.
'Man, I'm fuckin' feelin' it,' I whispered. My roommate Shannon had taken ten, and so did Jeff's girlfriend. None of them got anywhere with it, considering they had a smaller dose and had recently eaten. I was on an empty stomach, and was experienced in meditation so was able to channel it in a more propagating manner. The threshold was common, similar to psilocybin. The hallucinations were the results of a hefty bowl of decent cannabis that had set the experience in full motion.
Threshold (occuring in twenty minutes after ingestion): chakra points producing massive endorphin flooding, and concentration on the heart or the head yielded a floating, almost overly intense high.
 I wanted to write down some of the thought-processes, but they were slightly altered and confused and disappeared back into the subconscious to come back later in a different form.
The hallucinations were not as profound at first. I've smoked high doses of marijuana and seen amazing spiral activity in my retinal fields, this was similar to the rise of LSA. I began to feel the nausea, but dismissed it as the salvia. If I done research before hand, I probably would have had a better experience.
The purge. Wonderful and terrifying, it is as symbolic as it is uncomfortable. The vomiting was over, in the bathroom, the nausea like a vise around my stomach that clenched and released and made me swoon in vertigo. The trip was definitely becoming intense, and I propped myself against the wall of my two-bedroom apartment and was blessed with consolation from both Jeff and his girlfriend. My roommate was not feeling anything, and she left. After the experience began to intensify, I was actually worried about her suddenly 'coming up' and not knowing how to handle it. I vomited again outside, and sat down on the couch in a vegitative stance.
My mind, however, was far from vegitative. As with any intense experience, every little nuance of reality that is most often times taken for granted becomes a pounding cessation that yields either wonderous pleasure, or a sense of doom and terror. I honestly, at the time, felt I was going to die. I kept telling Jeff I wish I hadn't taken all fifteen, but just ten. The marijuana did not help at all, but I love the marijuana high and smoked some more anyway. The visuals became more crystal, and my head still felt as if it were holding on by bare tendons before releasing and floating off into space.
I must have entered my mind and lost touch with reality an hour later, because time was lost in the oblivion of space, which I discovered was only an illusion. The consordium of reality was but a vague incantation amidst a myriad of spiraling, gyrating colors not as intense as a psyilocybin, or DMT, but nonetheless captivating.
Catatonia, holding a cigarette that has long since burned out. I come to, realized that I was in an alternate dimension of reality, in which I was visiting a higher plane of evolution. A jump FORWARD through evolution to where time and space yielded a pocket, so to speak, specifically designed to house the three of us in the experience. Since I was the only one tripping, I really wasn't aware that Jeff and and his girlfriend were talking to me worriedly.
'Dude, he's knows where he is!' Callie argued with Jeff, 'Look, he's awake, he's moving around, he's alright' She then proceeded to ask me if I was alright.
'Yeah,' I responded as if totally sober and everything was perfect. 'I know exactly where I am.' I chuckled after that. Of course, in the sober reality they thought I was coming down from my trip and realized where I was. In all actuality, however, I was in another dimension, and they were as well, and we all were amazed that we were smart enough to realize where we were and not freak out about it. It was interesting, and after awhile the intensity of the alternate reality become unbearable, and I drifted out of it directly into my mind.
This is the peak of the experience. This is what is described in Fear and Loathing In Las Vegas as, 'the two-and a half hours or so of catatonic despair.' He was describing an acid dose, but LSA is similiar to acid. The dose I took could be compared to a moderate acid dose, and I very-well achieved the same plane of consciousness.
I was literally strung out in an infinite stretch of pain, clutching myself and floating through the abyss. The pain was similar to that of a complete body charlie-horse, where the muscles and the nerves were told by my brain to go into duress. Now I don't think any damage was being done, but at the time of the experience I was concentrating on moving into the pleasant field of space. I achieved, and a negative thought or fear invaded the perfection and sent my spiraling back into the pain. It was a back and forth sequence in my mind, and my thoughts were trying so hard to attain the true meaning of everything important, throwing aside everything worldly because it no longer mattered.
When I came to, I realized I was in my room. It was dark, everyone was asleep. The walls were still moving, but the hallucinations were only minor. My thoughts were still zig-zagging in terror, believing the room was Hell, and I had died, and I would spend eternity locked in my mind to balance out pain and pleasure and control chaos. For a moment I was happy, because it would mean I could create my own realities. I could design life and become a God of sorts.
I was crying when I realized what had happened, and I was crying with joy with I opened the door and saw the night-world was still there, and life was still happening. The beauty was more phantasmagoric than any psychedelic experienced, and I realized that that was the meaning behind the journey. To realize that you cannot become god, because the intricacies are so infinitely expanding that it resembles Chaos, although it is not. It is a governable reality through inherent laws given by the Universal Mind. Our thoughts, I realized, are dicated by our state of mind and our view of everything. Really, the only thing that mattered was the beauty of life, and its infinite complexity.
To feel the rhythm, to
Feel inspired, to
Feel connected,
Enough to step aside and weep like a widow. To feel inspired, to fathom the power, to witness the beauty, to bathe in the fountain, to swing on a spiral out.
(Tool, Lateralis)
Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid.


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Dolmexica Infinite, presented by Dogma 2018-2023
Documentation for release version (2023)
Updated 30 June 2023
Contents
This is an alphabetical index of function-type triggers that were added for Dolmexica Infinite. For details on the use of function-type triggers in expressions, see the expression documentation fom the original M.U.G.E.N documentation. Dolmexica Infinite also contains the triggers defined by M.U.G.E.N For documentation for those, consult the original M.U.G.E.N documentation as well. Changes to original triggers are documented in the Dolmexica Changes documentation.
For more information on triggers, check the original M.U.G.E.N trigger documentation. Unless otherwise specified, documentation style for Dolmexica triggers follows the outlines presented in the original M.U.G.E.N trigger documentation.
This trigger takes a mandatory variable number as an argument. It returns the value of the player's specified global float variable. Global variables carry over between fights/storyboards.
Example:
trigger1 = GlobalFVar(5) = -1.23 Triggers if the value of global float variable 5 is -1.23.
This trigger takes a mandatory variable number as an argument. It returns the value of the player's specified global string variable. Global variables carry over between fights/storyboards.
Example:
trigger1 = GlobalSVar(5) = "TestString" Triggers if the value of global string variable 5 is TestString.
This trigger takes a mandatory variable number as an argument. It returns the value of the player's specified global integer variable. Global variables carry over between fights/storyboards.
Example:
trigger1 = GlobalVar(5) = 23 Triggers if the value of global integer variable 5 is 23.
Returns platform Dolmexica is running on as string. Returns "dreamcast" on Dreamcast, "windows" on Windows, "web" on Web, "vita" on Vita.
Example:
trigger1 = Platform = "dreamcast" Triggers if Dolmexica Infinite is running on the Sega Dreamcast.


Quality Assurance and Behaviour-Driven Development
This is what it is and why it matters....asd;lfkjas;ldkfjas;ldkfja;lskdjflaskjfiewaoiefj;awiejf;lwakjef;lkjwae;lfjawiejf;aowiejf;oawiej;ljawe;flkjawl;ekfjlkj.
This is what it is and why it matters....asd;lfkjas;ldkfjas;ldkfja;lskdjflaskjfiewaoiefj;awiejf;lwakjef;lkjwae;lfjawiejf;aowiejf;oawiej;ljawe;flkjawl;ekfjlkj.
This is the explanation of how you do it.....
This is the explanation of how you do it.....
Single source of truth...
Explanation text.....
Test business rules at lowest possible level


“Year after year
On the monkey's face:
A monkey's face.”
― Matsuo Bashō
MACBETH FULL TEXT
Your browser does not support the video tag.


Array
constructors (no-array-constructor)Use of the Array
constructor to construct a new array is generally
discouraged in favour of array literal notation because of the single-argument
pitfall and because the Array
global may be redefined. The exception is when
the Array constructor is used to intentionally create sparse arrays of a
specified size by giving the constructor a single numeric argument.
This rule disallows Array
constructors.
Examples of incorrect code for this rule:
/*eslint no-array-constructor: "error"*/
Array(0, 1, 2)
/*eslint no-array-constructor: "error"*/
new Array(0, 1, 2)
Examples of correct code for this rule:
/*eslint no-array-constructor: "error"*/
Array(500)
/*eslint no-array-constructor: "error"*/
new Array(someOtherArray.length)
This rule enforces a nearly universal stylistic concern. That being said, this rule may be disabled if the constructor style is preferred.
This rule was introduced in ESLint 0.4.0.


- generateID() - Method in class com.example.bettertrialbook.home.MainActivity
-
Generates a unique ID per user Checks if ID is in database Adds ID to DB if
it's not Creates user object "you" to represent you
- Geolocation - Class in com.example.bettertrialbook.models
-
Geolocation class stores a location object containing the lat and lon of the trial's geolocation.
- Geolocation(Location) - Constructor for class com.example.bettertrialbook.models.Geolocation
-
Creates a Geolocation
- Geolocation(Parcel) - Constructor for class com.example.bettertrialbook.models.Geolocation
-
The Constructor used for passing a Parcel
- GeolocationActivity - Class in com.example.bettertrialbook.experiment
-
Handles the displaying of a map using Google Maps API
Set up done using: Google Maps Platform, 2021-04-07, Apache 2.0, https://developers.google.com/maps/documentation/android-sdk/current-place-tutorial
- GeolocationActivity() - Constructor for class com.example.bettertrialbook.experiment.GeolocationActivity
-
- GeolocationTest - Class in com.example.bettertrialbook
-
Unit tests for the Geolocation class
- GeolocationTest() - Constructor for class com.example.bettertrialbook.GeolocationTest
-
- GeoWarningFragment - Class in com.example.bettertrialbook.experiment
-
Fragment called when either:
No username entered
Username entered is already taken
Title of fragment changes depending on which reason it was called for
- GeoWarningFragment(String) - Constructor for class com.example.bettertrialbook.experiment.GeoWarningFragment
-
- GeoWarningFragment.OnFragmentInteractionListener - Interface in com.example.bettertrialbook.experiment
-
Ok pressed interface to continue after geolocation required warning displayed
- getActiveStatus() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets the active status of the experiment
- getActiveStatusTest() - Method in class com.example.bettertrialbook.ExperimentTest
-
- getBinFrequencyA(int) - Method in class com.example.bettertrialbook.statistic.HistogramInfo
-
Helper Method: Collect the frequency for each bins (At least equal or more than 5 bins)
- getBinFrequencyB(int) - Method in class com.example.bettertrialbook.statistic.HistogramInfo
-
Helper Method: Collect the frequency for each bins (Less than 5 bins)
- getBlacklist() - Method in class com.example.bettertrialbook.models.Trial
-
gets whether the trial is blacklisted or not
- getBlacklistUser(String, String, ExperimentDAL.IsBlacklistedCallback) - Method in class com.example.bettertrialbook.dal.ExperimentDAL
-
Returns blacklist status of user
- getCategory(int) - Method in class com.example.bettertrialbook.statistic.HistogramInfo
-
Helper Method: Obtain the category (label) for each bin which are used to plot the histogram
- getChild(int, int) - Method in class com.example.bettertrialbook.forum.ExpandableQuestionList
-
- getChildId(int, int) - Method in class com.example.bettertrialbook.forum.ExpandableQuestionList
-
- getChildrenCount(int) - Method in class com.example.bettertrialbook.forum.ExpandableQuestionList
-
- getChildView(int, int, boolean, View, ViewGroup) - Method in class com.example.bettertrialbook.forum.ExpandableQuestionList
-
- getContact() - Method in class com.example.bettertrialbook.models.User
-
Returns contactInfo object related to user object
- getCount() - Method in class com.example.bettertrialbook.models.NonNegTrial
-
gets the recorded count for the trial
- getCountTest() - Method in class com.example.bettertrialbook.NonNegTrialTest
-
- getDescription() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets the description of the experiment
- getDescriptionTest() - Method in class com.example.bettertrialbook.ExperimentTest
-
- getDeviceUserId(Context) - Method in class com.example.bettertrialbook.dal.UserDAL
-
Retrieves this device's user id.
- getEmail() - Method in class com.example.bettertrialbook.models.ContactInfo
-
Returns users email address
- getExperimenterID() - Method in class com.example.bettertrialbook.models.Trial
-
gets the experimenter who made the trial's id
- getExperimentId() - Method in class com.example.bettertrialbook.models.Post
-
Gets the post's experiment id
- getExperimentId() - Method in class com.example.bettertrialbook.models.QRCode
-
Gets the QR Code's associated experiment id
- getExperiments(String, ExperimentDAL.GetExperimentsByStatusCallback) - Method in class com.example.bettertrialbook.dal.ExperimentDAL
-
Gets all experiments of a certain status
- getGeolocation() - Method in class com.example.bettertrialbook.models.Trial
-
gets the geolocation of the Trial
- getGeoLocationRequired() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets whether or not geolocation is required for the experiment
- getGeoLocationRequiredTest() - Method in class com.example.bettertrialbook.ExperimentTest
-
- getGeolocationTest() - Method in class com.example.bettertrialbook.BinomialTrialTest
-
- getGeolocationTest() - Method in class com.example.bettertrialbook.CountTrialTest
-
- getGeolocationTest() - Method in class com.example.bettertrialbook.MeasurementTrialTest
-
- getGeolocationTest() - Method in class com.example.bettertrialbook.NonNegTrialTest
-
- getGroup(int) - Method in class com.example.bettertrialbook.forum.ExpandableQuestionList
-
- getGroupCount() - Method in class com.example.bettertrialbook.forum.ExpandableQuestionList
-
- getGroupId(int) - Method in class com.example.bettertrialbook.forum.ExpandableQuestionList
-
- getGroupView(int, boolean, View, ViewGroup) - Method in class com.example.bettertrialbook.forum.ExpandableQuestionList
-
- getId() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets the id of the experiment
- getId() - Method in class com.example.bettertrialbook.models.Post
-
Gets the id of the post itself
- getId() - Method in class com.example.bettertrialbook.models.QRCode
-
Gets the QR Code's id itself
- getID() - Method in class com.example.bettertrialbook.models.User
-
Returns the ID of the user object
- getIdTest() - Method in class com.example.bettertrialbook.ExperimentTest
-
- getInfo() - Method in class com.example.bettertrialbook.models.Experiment
-
gets the associated ExperimentInfo
- getInstance() - Static method in class com.example.bettertrialbook.dal.Firestore
-
Gets a FirebaseFirestore instance and wires it up to use our local emulator if the useEmulator
method has been called.
- getLabels() - Method in class com.example.bettertrialbook.statistic.HistogramInfo
-
Obtain the name for the bins in the X-Axis for the Histogram
- getLocation() - Method in class com.example.bettertrialbook.experiment.GeolocationActivity
-
Gets the user's current location
- getLocation() - Method in class com.example.bettertrialbook.models.Geolocation
-
gets the Geolocation's location
- getLocationTest() - Method in class com.example.bettertrialbook.GeolocationTest
-
- getMaxForEachBin(int, int) - Method in class com.example.bettertrialbook.statistic.HistogramInfo
-
Helper Method: Calculate the maximum value for each bin
- getMeasurement() - Method in class com.example.bettertrialbook.models.MeasurementTrial
-
gets the recorded measurement value for the trial
- getMeasurementTest() - Method in class com.example.bettertrialbook.MeasurementTrialTest
-
- getMinForEachBin(int[], int) - Method in class com.example.bettertrialbook.statistic.HistogramInfo
-
Helper Method: Calculate the minimum value for each bin
- getMinTrials() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets the min number of trials needed for the experiment
- getMinTrialsTest() - Method in class com.example.bettertrialbook.ExperimentTest
-
- getOffset() - Method in class com.example.bettertrialbook.statistic.Marker
-
- getOwnerId() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets the ownerId of the experiment
- getPhone() - Method in class com.example.bettertrialbook.models.ContactInfo
-
Returns user's phone number
- getPosterId() - Method in class com.example.bettertrialbook.models.Post
-
Gets the poster's id
- getPublishStatus() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets the publish status of the experiment
- getPublishStatusTest() - Method in class com.example.bettertrialbook.ExperimentTest
-
- getQuestionId() - Method in class com.example.bettertrialbook.models.Reply
-
Gets the question's id
- getRegion() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets the region of the experiment
- getRegionTest() - Method in class com.example.bettertrialbook.ExperimentTest
-
- getReplies() - Method in class com.example.bettertrialbook.models.Question
-
Gets the post's list of replies
- getSubscribed(String, UserDAL.GetSubscribedCallback) - Method in class com.example.bettertrialbook.dal.UserDAL
-
Gets all subscribed experiments of a user
- getSubscribedExperiments() - Method in class com.example.bettertrialbook.models.User
-
Returns list of experiment IDs user is subscribed to
- getSuccess() - Method in class com.example.bettertrialbook.models.BinomialTrial
-
get whether it was a success or failure
- getSuccessTest() - Method in class com.example.bettertrialbook.BinomialTrialTest
-
- getText() - Method in class com.example.bettertrialbook.models.Post
-
Gets the text of the post
- getTheDataTest() - Method in class com.example.bettertrialbook.StatisticNonNegTest
-
- getTheDates() - Method in class com.example.bettertrialbook.statistic.LineGraphInfo
-
Helper Method: Obtain the distinct dates (yyyy.MM.dd) for the trails in the experiment
- getTimestamp() - Method in class com.example.bettertrialbook.models.Trial
-
gets the timestamp of when the trial was created
- getTitle() - Method in class com.example.bettertrialbook.models.Question
-
Gets the post's title
- getTrialId() - Method in class com.example.bettertrialbook.models.QRCode
-
Gets the QR Code's associated trial id
- getTrialID() - Method in class com.example.bettertrialbook.models.Trial
-
gets the id of the trial
- getTrialIdTest() - Method in class com.example.bettertrialbook.BinomialTrialTest
-
- getTrialIdTest() - Method in class com.example.bettertrialbook.CountTrialTest
-
- getTrialIdTest() - Method in class com.example.bettertrialbook.MeasurementTrialTest
-
- getTrialIdTest() - Method in class com.example.bettertrialbook.NonNegTrialTest
-
- getTrialType() - Method in class com.example.bettertrialbook.models.BinomialTrial
-
gets the type of trial/experiment associated with the trial
- getTrialType() - Method in class com.example.bettertrialbook.models.CountTrial
-
gets the trial/experiment type of the trial
- getTrialType() - Method in class com.example.bettertrialbook.models.ExperimentInfo
-
gets the trial type of the experiment
- getTrialType() - Method in class com.example.bettertrialbook.models.MeasurementTrial
-
gets the trial/experiment type for the trial
- getTrialType() - Method in class com.example.bettertrialbook.models.NonNegTrial
-
gets the type of experiment/trial for the trial
- getTrialType() - Method in class com.example.bettertrialbook.models.Trial
-
gets the type of trial/experiment for the trial
note this is implemented in other classes extending this one
- getTrialTypeTest() - Method in class com.example.bettertrialbook.BinomialTrialTest
-
- getTrialTypeTest() - Method in class com.example.bettertrialbook.CountTrialTest
-
- getTrialTypeTest() - Method in class com.example.bettertrialbook.ExperimentTest
-
- getTrialTypeTest() - Method in class com.example.bettertrialbook.MeasurementTrialTest
-
- getTrialTypeTest() - Method in class com.example.bettertrialbook.NonNegTrialTest
-
- getType() - Method in class com.example.bettertrialbook.models.Question
-
Gets the type of the post (question)
- getType() - Method in class com.example.bettertrialbook.models.Reply
-
Gets the post's type (reply)
- getUnusedId() - Method in class com.example.bettertrialbook.dal.QRDAL
-
Retrieves an Id that hasn't been used yet
- getUser() - Static method in class com.example.bettertrialbook.You
-
- getUsername() - Method in class com.example.bettertrialbook.models.User
-
Returns the username of the user object
- getView(int, View, ViewGroup) - Method in class com.example.bettertrialbook.experiment.CustomTrialList
-
- getView(int, View, ViewGroup) - Method in class com.example.bettertrialbook.home.ExperimentList
-


The size allocated to render the edge detour.
The minimum size allowed for an edge.
Defines the stroke width of the edge.
Defines the unique arrow marker id.
The edge's CSS style.
This defines the position and the size of the edge in the DOM. The position relies on the nodes' from and to position. This also accounts for the padding which is needed so that it won't be rendered right at the edge of the container.
Whether the arrow marker is rendered at the end of the path
.
Whether the arrow marker is rendered at the start of the path
.
The edge's padding size.
For edges that go backward, it adds an extra padding from the detourSize so that the detour won't be rendered near the edge of the container.
The height relative to the start and the end of the edge.
Relative position of the start and end in the SVG.
It is determined by the actual position of the nodes relative to the SVG position in the DOM
The width relative to the start and the end of the edge.
Defines the shapeRendering
property in the path
.
It is only needed for certain types of edges.
Defines the viewBox
property of the SVG.
Based on the edge's container size itself.
Generated using TypeDoc
The Flowter edge's renderer mixin. This mixin extends the props.


Foo
Editor’s Draft,
1 January 1970
This version:
http://example.com/foo
foo
Editor:
Example Editor
COPYRIGHT GOES HERE
Abstract
Testing merging of custom metadata with existing metadata.
Table of Contents
References
References


Assembling a genome from short-reads is actually quite a difficult thing. But it is tractable and you can get an awful lot of information from the draft assemblies that result. This little walkthrough of the basic technique, originally written for the TSL EMBO Practical in 2012, should give a good idea of the work that goes into it. You should be able to follow along in Galaxy on the TSL site.
So, you’ve got a genome sequence. But this is Plant-Microbe interactions? Where the devil are those blasted effectors? Which is the one that makes my organism pathogenic?
Hopefully this little technique introduction will help you get an idea of what sort of genomic analyses you can use to find the effectors in a fresh, unsullied genome assembly.
Single-nucleotide polymorphisms (SNPs) are variations in nucleotide composition at homologous sites of different species. They may lead to change of function or expression of a gene through the introduction of premature stop codons, different protein folds or a change in gene expression. SNPs may be linked to a gene for a given trait, for example the resistance to a pathogen.
RNA-seq is a method used to sequence the transcribed genes in a given organism. The RNA of an organism is sequenced and the reads are then mapped to a reference genome. The number of genes that map to a given gene are a value of it’s expression – the more reads that map, the higher the gene is expressed.
post_infection_left_qc.fastqsanger
post_infection_right_qc.fastqsanger


Welcome to Groundswell
What is surf paradise? Is it a place? A state of mind? What does surf paradise mean to you? Groundswell is all about finding that place. Whether it's checking out the latest gear, immersing yourself in the surfing lifestyle, or watching some of the sickest video this side of the pipeline, we've got you covered.
On our site you'll find:
- The latest gear
- Surfing journals
- Surfing photos
- Competition videos
- Surf condition reports
- ... and much more!

Latest News
Simon Craven wins the Maui invitational.
Late July saw some of the best surfing the world has ever seen. The water temperature and currents brought perfect conditions for the Maui Invitational and the field wasted no time in shredding last year's scores. When the dust settled Simon Craven won his first ever Maui title. Fresh off his win in Australia, it looks like Simon's a name we'll be hearing a lot of in the future!
Velosurty releases new board
Up and coming surf shop Velosurty released a their new long board last month. “Keerang!” echo's the super-hero theme of their last long board, “Bang-Pow!” Artist Kelly Crandle supplies the look and feel. This board guarantees a smooth ride and eye-catching looks. In stores next month. While you're at it, check out our new boards as well!
Like the new look?
You may have noticed things look a little different here at Groundswell! We'll we decided it was time for a change and wanted a fresher look. Thanks to the awesome web techniques we learned from lynda.com, we were able to completely redesign the site. If you are interested in web design at all you should probably check them out as well!


Ship Upgrades¶
Your ship has ability to improve through modules. These modules can enhance different facets of the ship and can help your ship perform to the best of its capabilities.
Your ship will only have access to 4 total slots, and the unlock cost will increase per slot, so choose your modules wisely.
List of Modules¶
There are 5 groupings of modules for the ship:
Hull Strength
- How much damage you can takeEngine Speed
- How fast your ship can move in one tickWeapon Damage and Range
- How powerful the weapon is and what range you can attack enemiesCargo Space and Mining Yield
- How much space your ship has to store items, and at what speed your ship can mine for resourcesSensor Range
- How far your ship’s sensors can detect ships
How To Upgrade¶
Your ship starts at level 0 for all categories. In order to purchase a module you must specify which module slot to place the module in.
To purchase modules, go to the center station and use the buy_module
function. If you already have the module of the type you wish to upgrade,
it will upgrade that module in the slot. If you do not already own that module type, you will need to purchase the module itself and the module slot.
Keep in mind, only 4 total slots for modules can be obtained (1 of which is provided for you), so choose your modules wisely.
For any modules, you must purchase an additional slot for the module from the selling Stations.
Module Table¶
| Upgrade Enum | Stat Upgraded | Level 0 | Level 1 | Level 2 | Level 3 | Illegal |
|---|---|---|---|---|---|---|
| ModuleType.hull | Hull Strength | 1000 | 3645 | 4506 | 6243 | 10000 |
| ModuleType.engine_speed | Engine Speed | 5 | 7 | 9 | 11 | 15 |
| ModuleType.weapons | Weapon Damage | 83 | 270 | 458 | 645 | 2081 |
| Weapon Range | 25 | 50 | 75 | 100 | 125 | |
| ModuleType.cargo_and_mining | Cargo Space | 500 | 600 | 700 | 800 | 1000 |
| Mining Yield | 5 | 6 | 7 | 8 | 10 | |
| ModuleType.Sensors | Sensor Range | 75 | 100 | 125 | 150 | 175 |
Module Price Table¶
Module and module slot prices are dependent on the median price of all the materials in the universe. To find the cost of a module or a module slot, take the price listed below and multiply it by the median price in the universe.
In game, you should be using self.get_module_price(median_price, ship_slot).
Please note that all ships are outfitted with the level 0 modules, and all ships start with module slot 0.
+----------------+---------+---------+---------+---------+---------+
| Module Upgrade | Level 0 | Level 1 | Level 2 | Level 3 | Illegal |
+================+=========+=========+=========+=========+=========+
| Price | base | 100 | 400 | 900 | 1600 |
+----------------+---------+---------+---------+---------+---------+
+---------------+---------+---------+---------+---------+
| Module Slot | Slot 0 | Slot 1 | Slot 2 | Slot 3 |
+===============+=========+=========+=========+=========+
| Price | base | 150 | 225 | 300 |
+---------------+---------+---------+---------+---------+


Picnic with Att
2014.12.29
Around unconfirmed
Around unconfirmed
TBD
This session is designed for elders. Younglings should look forward to the evening session.
TBD
This session is designed for young people and someone with youth at heart.
This website is made with love on Mac by Juti and built for very modern browsers, including Safari for iOS 7.
All photographers used on this website is copyrighted by Juti, Atthapol and Picnic(?).


Preparation time
30 mins to 1 hour
Cooking time
30 mins to 1 hour
Serves
Serves 4
Making your own pasta is worth it for this luxurious dish that makes the most of fresh crab.
For the linguine, put the flour on a work surface, make a well in the centre and add the beaten eggs, salt and oil. Using your fingertips in a circular motion, slowly incorporate the flour into the egg mixture, adding a little water if necessary, to form a dough.
Knead for 5 minutes, until the dough is elastic and springs back when gently pressed. Cover with cling film and allow to rest for at least 30 minutes in the fridge.
Roll the pasta dough out in 4-6 batches using a pasta machine working from the thickest to the penultimate setting, allowing the sheets to dry for 10 minutes uncut. Pass the rolled sheets through the linguine cutter on the machine and hang the linguine over a coat hanger or similar to air while you cook the sauce.
For the sauce, put the leek, parsley sprigs, 300ml/10fl oz of the wine, 5 whole garlic cloves in a large stock pot with enough water to cover the crabs. Bring to the boil, add the crabs and cook for about 6 minutes.
Remove the crabs from the hot water and place immediately into iced water. When the crabs are cold, remove the meat from each. Open the body, remove all the brown meat and set aside. Remove the white meat from the skinny legs but leave the claws. Mix the white and brown meat together. Crack the claws but leave whole. Place the claws in a baking dish, pour over the pesto and leave to marinate. Clean out the crab shells.
Preheat the oven to 200C/180C Fan/Gas 6.
Heat the olive oil in a large saucepan, add the chopped garlic, chilli, brown and white crab meat, courgettes and chopped parsley. Fry for 1 minute then add the remaining wine. When the sauce has bubbled down and thickened, remove from the stove.
Bake the marinated crab claws in the oven for 2 minutes to heat through.
Meanwhile, bring a large pan of salted water to the boil and cook the fresh linguine for 2–3 minutes, drain and add to the sauce. Mix together and serve immediately.
Present the dish with the linguine and sauce in a warmed pasta plate with a crab claw on top.
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How to cook pasta perfectly


--- layout: post status: publish published: true title: Podcast 2.13 - Change is in the air? author: display_name: Corey Fineran login: Corey email<EMAIL_ADDRESS>url: '' author_login: Corey author_email<EMAIL_ADDRESS>wordpress_id: 2766 wordpress_url: http://ivyenvy.com/?p=2766 date: '2010-06-06 10:41:33 +0000' date_gmt: '2010-06-06 15:41:33 +0000' categories: - Podcast tags: [] comments: - id: 1361 author: Ryan author_email<EMAIL_ADDRESS>author_url: '' date: '2010-06-06 14:30:54 +0000' date_gmt: '2010-06-06 19:30:54 +0000' content: "Most upset I have ever been about the Cubs losing somebody would have to be Mark Grace, and it didn't help that he won a world championship shortly thereafter. \r\n\r\nInstant replay needs to be injected (which is kind of an unfortunate word to have to use) into baseball culture. Think of how silly this is: The only guy on the field that needed to see the Jumbotron wasn't allowed to look at it in review. That's ridiculous.\r\n\r\n\"Dude, shut your hole\" - Andrew Round\r\n\r\nMeehan" ---
Andy, Corey and Kurt discuss the current state of the 2010 Cubs and the choices management faces. Whisperings of interest from the Angels in Derrek Lee is forcing us to consider the idea of the Cubs losing players we have grown to love. Kurt gives us a little review of the new ballpark in Minneapolis and we look at the idea of instant replay in baseball with the Question of the Week.


@grewalsatinder I've initialised such list of tokens with names this way:
tokens_ids = json.loads(check_output(
["komodo-cli","-ac_name="+ac_name,"tokenlist"]))
tokens_list = {}
for token_id in tokens_ids:
tokens_info = json.loads(check_output(
["komodo-cli","-ac_name="+ac_name,"tokeninfo",token_id]))
tokens_list[tokens_info["name"]] = tokens_info["tokenid"]
return tokens_list
Worked pretty fast. I guess it's possible to implement something similar to sync only server each X seconds and clients will get output from this static list
(edited)


{% extends 'base.html' %} {% load staticfiles %} {% block center_data %}
Pulak Lakhani is one of top Motivational Speakers in India, with an experience of over 39 years. Smart, Suave and Charismatic, TsMadaan is endowed with penetrative mind, amazing spontaneity and clarity of thoughts. His sessions are designed to infuse tremendous dynamism and vigour into the participants, to help them grow personally and professionally. His specialisation is in Life Skills viz. Human Relations, Behaviour, Self Confidence, Positive Thinking, Emotions (Anger, Grief, Sorrow, Fear, Frustration, Boredom etc.) Management, Stress Management, Time Management, Leadership etc. and Selling Skills viz. Prospecting, Cold Calling, Need Analysis, Follow ups, Customer Service, Closing Sales etc. The Contents are designed as per your needs, interests, expectations and concerns. The results are noticeable immediately. The delivery style is Interactive, Entertaining and Powerful.
His sessions are blend of funny, humorous, informative, educative training. He has his clientele from FMCG, Pharmaceutical, Banking, Life Insurance, MLM, Direct Selling, Consumer Durables, Retail, Real Estate, IT etc. He delivers his sessions in Hinglish, a blend of Hindi and English as generally spoken in organisations. Keeping audience mesmerised for 3 hours, more than a bollywood movie, is USP of TS Madaan.


- Andrea Authoriser
- Casterbridge College
- UKPRN:12345678
Your subcontractor declaration
The college of Birmingham Ready to declare
- UKPRN: 12345678
- Company number: 654321
- Funding streams: 16 to 18 apprenticeship, 16 o 18 apprenticeships, ESF
The college of Coventry Ready to declare
- UKPRN: 12345678
- Company number: 654321
- Funding streams: 16 to 18 apprenticeship, 16 o 18 apprenticeships, ESF
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Submit declaration back to your subcontractors list


The first paragraph in body.
The second paragraph in body.
The first paragraph in div (and the 2nd child in this div).
The second paragraph in div.
The last paragraph in div.
The first paragraph in another div.
The second paragraph in another div (and the 2nd child in this div).
The last paragraph in another div.
The last paragraph in body.


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CodeAFriend
A website for submitting and voting on code samples that solve user submitted problems. Will only support python at first.
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Implementation of ILanguageInterpreter for Python programming language. More...
Public Member Functions | |
| override ProcessStartInfo | GetProcessStartInfo (string scriptFilePath) |
| Public Member Functions inherited from CodeAFriend.Languages.Core.InterpreterTemplate | |
| async Task< ScriptEvaluation > | ExecuteAsync (string body, ExecutionParameters parameters) |
| Execute code written in Name language using the specified ExecutionParameters. More... | |
| virtual async Task< string > | WriteScriptToFileAsync (string scriptBody) |
| virtual async Task< ScriptEvaluation > | RunProcessAsync (ExecutionParameters parameters, ProcessStartInfo startInfo, string scriptFilePath) |
Properties | |
| override SupportedLanguage | Name = SupportedLanguage.Python37 [get] |
| Properties inherited from CodeAFriend.Languages.Core.InterpreterTemplate | |
| abstract SupportedLanguage | Name [get] |
| Properties inherited from CodeAFriend.DataModel.ILanguageInterpreter | |
| SupportedLanguage | Name [get] |
| The language this ILanguageInterpreter interprets. More... | |
Implementation of ILanguageInterpreter for Python programming language.
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virtual |
run to create an alias
doskey python3="C:\Program Files\Python37\python.exe"
Implements CodeAFriend.Languages.Core.InterpreterTemplate.
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get |