List all Reports for an Institute or Center for a particular year
All Annual Reports for NIMH for reporting year 2010
125 Annual Reports
Investigator-Initiated Project
1.
MH000274 (2010) Methods In Mass Spectrometry
Sanford P. Markey, PhD
Mass spectrometric methods for the analysis of protein structures are being improved, applied and tested in independent and collaborative research projects in proteomics. Projects in separation methods and data processing are in progress. In the past year, progress has been made on implementation of ...
2.
MH000279 (2010) Proteomics in neurotoxicology
Sanford P. Markey, PhD
We are applying proteomic methodology to unresolved problems in neuropathologic diseases. Progress continues in studies on the structure of the postsynaptic density and its remodeling by drugs used in the treatment of mood disorders, on protein complexes implicated by genomic studies of schizophren ...
3.
MH000332 (2010) Genetic Animal Models for the Study of Serotonin Function and Behavior
Dennis L Murphy, MD
As recently reviewed, SERT-deficient Slc6a4 +/- and -/- mice have gene-proportionate increases in extracellular fluid serotonin (5-HT) concentrations, i.e., 3- or 6-fold excesses respectively over +/+ mice (Murphy et al., 2008; Murphy & Lesch 2008; Fox et al., 2007, 2009, 2010; Brigman et al., 201 ...
4.
MH000336 (2010) The Genetics Of Obsessive Compulsive Disorder
Dennis L Murphy, MD
OCD is a severe, heritable condition with a lifetime prevalence of about two percent of world populations. The mode of inheritance is incompletely understood but is likely complex, involving multiple genetic loci of small to moderate effect. Our laboratory has played a leading role in studies of OCD ...
5.
MH000478 (2010) Neural Mechanisms Of Stimulus Memory And Habit Formation
Mortimer Mishkin, PhD
The essential circuit for both item and associative stimulus recognition in any given sensory modality consists of the relevant cortical sensory processing stream(s), the medial temporal periallocortex (i.e. parahippocampal, rhinal cortices), the ventromedial prefrontal cortex, and the medial dorsal ...
6.
MH000889 (2010) Studies On Protein Synthesis And Long-Term Adaptive Responses in the CNS
Carolyn E Beebe, PhD
During the last funding period (2010), we addressed the following specific aims:
1) Determine rCPS in human subjects with FXS
2) Refine numerical techniques for analysis of PET data to determine rCPS
3) Test the effects of chronic lithium treatment on rCPS in a mouse model of FXS
4) Determi ...
7.
MH001090 (2010) Studies Of Central Nervous System Functional Anatomy
Miles Herkenham, PhD
Chronic stress has been implicated in the cause and progression of various psychiatric disorders including depression and post-traumatic stress disorder (PTSD). In a project focused on the effects of an ethologically valid form of chronic stress, we are exploring the effects of social conflict stre ...
8.
MH001101 (2010) Cortical Mechanisms Of Auditory Perception And Memory
Mortimer Mishkin, PhD
The cortical auditory system is far more extensive than expected, as it includes not only the entire superior temporal gyrus (STG) but also large portions of the parietal, prefrontal, and limbic lobes. Evidence from neuroimaging studies in monkeys from our lab and those of others have raised the po ...
9.
MH002032 (2010) Neural Coding Of Visual Stimuli
Barry J Richmond, MD
Categorization is a basic mental process that helps individuals distinguish among groups of negative and positive objects, e.g., poisons and nutrients, or predators and prey without having to learn about each individual stimulus from scratch. Both the inferior temporal cortex (ITC) and the prefronta ...
10.
MH002035 (2010) Functional Anatomy Of Perceptual and Attentional Systems in the Primate Brain
Leslie G Ungerleider, PhD
A typical scene contains many different objects that compete for neural representation due to the limited processing capacity of the visual system. At the neural level, competition among multiple stimuli is evidenced by the mutual suppression of their visually evoked responses and occurs most strong ...
11.
MH002039 (2010) Pharmacology Of Stimulus Memory And Habit Formation
Mortimer Mishkin, PhD
The importance of the cholinergic system in memory function was first recognized because the memory impairment characteristic of Alzheimers disease was associated with the loss of large cholinergic neurons of the basal forebrain and pathophysiology of the entorhinal/perirhinal, or rhinal cortex. We ...
12.
MH002179 (2010) Animal Models Of Neuropsychiatric Disorders
Jacqueline N Crawley, PhD
Autism is a neurodevelopmental disorder that affects approximately 0.6% of the U.S. population. The causes of autism spectrum disorders are under intense investigation, with strong evidence for genetic substrates. Lifetime costs of caring for autistic individuals are high, both in terms of a) qual ...
13.
MH002228 (2010) Genetic Neurobiology Of Drosophila
Howard A. Nash, MD, PhD
By definition, genes that confer a phenotype when their copy number is changed encode factors that are limiting for physiological processes. In search of dosage-sensitive genes that influence arousal and/or its suppression by anesthetics, we previously screened for changes in sensitivity to halotha ...
14.
MH002240 (2010) Neurobiology Of Disruptive Behavior Disorders
Judith L Rapoport, MD
Over the past year several key findings have emerged.
(1) In a recent longitudinal study we found that the disorder was characterized by anomalous development of cortical asymmetry (Shaw, Lalonde et al. 2009). In early childhood, the left orbitofrontal/prefrontal cortex and right parieto-occipi ...
15.
MH002344 (2010) Neuropsychiatric Disorders--protein Structure/activity Studies
Brian M Martin, PhD; Sanford P. Markey, PhD
The unambiguous identification of proteins/peptides is crucial for the definition of the proteome. Using ProteinChip Array technology (SELDI) we have developed experimental protocols and probed test conditions required for protein identification on ProteinChip Arrays. We are able to directly digest ...
16.
MH002386 (2010) Chemical Coding Of Neurotransmission
Lee E Eiden, PhD
The neuropeptide slow transmitter PACAP (pituitary adenylate cyclase activating polypeptide) is released at synapses that transduce stress responses to the brain, and mediate homeostatic adjustments to stress by the organism. Allostatic responses to systemic and psychogenic stressors at multiple poi ...
17.
MH002399 (2010) Postmortem Brain Tissue Examination in Neuropsychiatric Disorders
Joel Kleinman, MD, PhD
The Section of Neuropathology supports the primary goal of the CBDB which uses evidence of genetic association to generate and test hypotheses about how specific genes affect brain development, plasticity and function and how these effects relate to biology leading to potential treatment of illness. ...
18.
MH002468 (2010) Mechanisms Of Action Of Psychoactive Drugs
De Maw Chuang, PhD
The Section on Molecular Neurobiology continued investigating the neurobiology of mood stabilizing drugs, notably valproic acid (VPA) and lithium. The working hypothesis is that VPA and lithium, by inhibiting their initial targets histone deacetylases (HDACs) and glycogen synthase kinase-3 (GSK-3), ...
19.
MH002497 (2010) Functional Organization Of The Basal Ganglia
Charles R Gerfen, PhD
Further work on the cellular mechanisms underlying neurologic and pscyhiatric disorders is limited by the fact that neurons throughout the brain utilize common mechanisms for critical functions such as synaptic plasticity, whereas specific neural systems are affected in different disorders. A large ...
20.
MH002498 (2010) Regulation Of Gene Expression In The Brain
Walter Scott Young, MD, PhD
--We have continued this fiscal year to study our gene knockouts (KO) of the mouse oxytocin (Oxt) and vasopressin (Avp) 1a and 1b receptors (Oxtr, Avpr1a and Avpr1b, respectively) to investigate their specific roles in mediating behavior. We are also continuing to analyze whether we were successful ...
21.
MH002537 (2010) Psychobiology And Treatment Of Perimenopausal Mood Disorders
Peter J Schmidt, MD
A role of estradiol withdrawal in the onset of mood disorders in some perimenopausal women has been suggested indirectly by the clustering of depressive episodes during the late menopause transition (the stage of ovarian aging associated with maximal decline of ovarian estradiol secretion) and by es ...
22.
MH002581 (2010) Childhood Onset Schizophrenia
Judith L Rapoport, MD
We recently completed whole genome screening for copy number variants (CNVs) using Illumina 1M SNP arrays in pediatric patients who were excluded from the COS study for various reasons, as well as all available first degree relatives. There was a wide range of diagnoses among the 82 excluded patient ...
23.
MH002585 (2010) Role of Neuroendocrine Stress Response in Inflammatory and Behavioral Illness.
Esther M Sternberg, MD
PROJECT I. Sweat Patch Biomarkers: Clinical Studies. We previously showed that neural and immune biomarkers are detectable in sweat and strongly correlate with plasma levels in a group of women with major depressive disorder (MDD) in clinical remission (Marques-Deak, 2006, J Immunol Methods; Cizza 2 ...
24.
MH002588 (2010) The Neural Foundations for Memory and Social Cognition In The Human Brain
Alex Martin, PhD
This past year we have continued to focus on a major part of long-term memory, termed semantic memory, that is composed of general information, such as facts, ideas, and the meaning of objects and words (i.e., concepts). We are particularly interested in characterizing the neural substrate mediating ...
25.
MH002592 (2010) Viral And Cellular Factors Governing Efficient Gene Delivery
Maribeth V Eiden, PhD
The Section on Directed Gene Delivery assesses the ability of retroviral vectors to deliver genes to the central nervous system and the role of retroviruses in various neurological disorders. Over the course of last year the Section has made improvements to the design of viral vectors used for thera ...
26.
MH002619 (2010) Neural Mechanisms Of Motivation And Reward
Barry J Richmond, MD
Adjusting motivation in proportion to the desirability of an outcome drives most normal behavior. The intensity or vigor of the behavior can be used to infer the value of the current behavioral context, for example, the value of a reward predicted by a visual stimulus. We study motivation in monkeys ...
27.
MH002629 (2010) HIV Nef Function and Early Events in Macrophage and Microglia Infection
Jon W. Marsh, PhD
The objective of this study is to elucidate those early events in HIV infection that may lead to pathogenesis.
Macrophages are infected in the circulatory system as well as in the brain. We have identified the early innate immunological responses following HIV infection of primary human macrop ...
28.
MH002652 (2010) Imaging of Neuropsychiatric Disorders with Developmental and Genetic Mechanisms
Karen F Berman, MD
Through our ongoing integrative neuroimaging studies of a unique and growing cohort of medication-free patients with schizophrenia, our group continues to make progress toward its goals of understanding the nature, molecular underpinnings, underlying neurochemistry, and clinical correlates of neural ...
29.
MH002666 (2010) Evaluation and Treatment of Obsessive Compulsive and Related Disorders
Susan Elizabeth Swedo, MD
There are two projects within this research portfolio. The first includes a series of studies of children in the PANDAS subgroup (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) and the second is a clinical trial of riluzole - a glutamate antagonist wi ...
30.
MH002685 (2010) Peptide Receptor Systems
Theodore B Usdin, MD, PhD
A current major focus of the laboratory is investigation of the physiological functions of the neuropeptide Tuberoinfundibular Peptide of 39 residues (TIP39) and its receptor, the Parathyroid Hormone 2 (PTH2) receptor. These molecules were discovered in this laboratory several years ago. In previo ...
31.
MH002711 (2010) Analytic Strategies and Cognitive Task Design to Study Neuropsychiatric Disorder
Daniel R. Weinberger, MD
The Neuropsychology lab as well as others in CBDB/GCAP, have previously shown that phenotypes related to abnormal executive cognition and cognitive control are associated with genetic risk for developing neuropsychiatric disorders and suggested that susceptibility genes impact on the neural processi ...
32.
MH002712 (2010) Characterization Of Neuropsychological Impairment In Schizophrenia
Daniel R. Weinberger, MD
Reviews by Elvevg and Weinberger (Cognitive Neuropsychiatry, 2009) and Dickinson and Elvevg (Neuroscience, 2009) explored 1) how the catechol-O-methyltransferase (COMT) polymorphism valine158methionine (val/met) has helped to characterize various interacting aspects of complexity with relation to ge ...
33.
MH002716 (2010) MRI Studies of Brain Function and Metabolism
Daniel R. Weinberger, MD
Identifying genes associated with risk for schizophrenia has allowed us to generate hypotheses about molecular and neural system mechanisms related to biologic aspects of the illness. By using a convergent validation strategy of cognitive, neuroimaging and basic science offers the ability to identif ...
34.
MH002717 (2010) Neuroimaging of Brain Circuits and Neurogenetic Mechanisms in Normal Cognition
Karen F Berman, MD
The Section on Integrative Neuroimaging continues to make advances toward our goals of elucidating systems-level neurobiological mechanisms underlying genetic predisposition to neuropsychiatric disease. To this end, recent progress has taken the form of key investigations of two central neural syst ...
35.
MH002734 (2010) Genetic Basis Of Cortical Malfunction In Schizophrenia
Daniel R. Weinberger, MD
We have continued to extend our studies of cortical processing in patients with schizophrenia and their healthy siblings in an effort to further refine the phenomenology of this increased risk trait related to cortical function. These studies have involved 1) a more refined analysis of subprocesses ...
36.
MH002736 (2010) Neural Substrates Of Stimulus Recognition And Association Memory
Elisabeth Adams Murray, PhD
The prevailing model of conscious memory holds that a group of loosely related structures, collectively called the medial temporal lobe (MTL), work together as a single functional unit. According to this current orthodoxy, the structures in the MTL are thought to store the memory of specific objects ...
37.
MH002762 (2010) Mechanistic studies on stress, inflammation and neuroprotection
Juan M. Saavedra, MD
Summary:
Our first specific aim is to clarify the mechanisms involved in the beneficial effects of compounds which have not, until very recently, been considered of interest to the therapy of brain disorders. The second specific aim is to further establish the extent of therapeutic benefits of suc ...
38.
MH002768 (2010) Subcellular Compartmentilization of Neuronal Gene Expression
Barry Bernard Kaplan, PhD
Axons and nerve terminals are unique subcellular structures of the neuron that play a critical role in the development and maintenance of neural connectivity. One of the central tenets in neuroscience is that the protein constituents of these distal neuronal compartments are synthesized in the nerve ...
39.
MH002778 (2010) The Phenomenology And Neurophysiology Of Juvenile Bipolar Disorder
Ellen Leibenluft, MD
Since the beginning of this project we have screened over 1200 subjects for this study. We have enrolled approximately 150 youth with bipolar disorder (BD), 180 subjects at risk for BD because they have a parent or sibling with the illness, 200 control subjects, and 75 adults with BD. This year, ap ...
40.
MH002780 (2010) Fmri Studies Of Emotional Development
Daniel Pine, MD
Work in the current set of projects has major public impact because it shapes understandings of the boundaries of normal development. In the absence of such understanding, it is impossible to precisely demarcate the boundaries of abnormal development.
There is a particular interest in using th ...
41.
MH002781 (2010) fMRI Studies Of Pediatric Mood And Anxiety Disorders
Daniel Pine, MD
Through a series of three protocols, we are using functional magnetic resonance imaging (fMRI) to examine neurocognitive correlates of pediatric mood and anxiety disorders. Through ongoing collaborative studies, we also have increasingly compared findings in these syndromes with findings in adult a ...
42.
MH002782 (2010) Fmri Studies Of Risk For Mood And Anxiety Disorders In Children
Daniel Pine, MD
In this project, our group is examining biological aspects of risk for mood and anxiety disorders in children. Such work has major public impact. By identifying biological risks in children, information on novel treatments and preventative interventions will emerge. Given the understanding of mos ...
43.
MH002783 (2010) Functional MRI Method Development
Peter A Bandettini, BS, PhD
The Functional Imaging Methods (FIM) section continues to develop cutting edge methods at the interface of technology development, processing advances, basic neurophysiology, and neuroscience applications. Specifically, this report describes progress in our research towards making MRI and fMRI more ...
44.
MH002784 (2010) Neurogenesis In The Adult Brain
Heather A Cameron, PhD
We study the regulation and function of adult neurogenesis in rats and mice, which show continued production of new neurons throughout adulthood similar to that in primates, including humans. During the past year, we have completed a study comparing adult neurogenesis in rats, a species commonly use ...
45.
MH002786 (2010) The Pathophysiology and Treatment Of Children With Severe Mood Dysregulation
Ellen Leibenluft, MD
Considerable public attention has focused recently on the question of why there has been a rather dramatic upsurge in the rate at which the diagnosis of bipolar disorder (BD) is being assigned to children. In large part the upsurge appears to be due to the fact that children with extremely severe ir ...
46.
MH002793 (2010) PET Radiopharmaceutical Sciences
Victor W Pike, PhD
The Molecular Imaging Branch (MIB) aims to exploit positron emission tomography (PET) as a radiotracer imaging technique for investigating neuropsychiatric disorders, such as depression, addiction, schizophrenia and Alzheimer's disease. Fundamental to the mission of the MIB is the development of nov ...
47.
MH002794 (2010) Pediatric Brain Imaging
Jay Giedd, MD
A unifying theme emerging from our work is that in neuroimaging, as in life, the journey is often as important as the destination. Trajectories of brain morphometry, as opposed to snapshots in time, are more highly correlated with cognitive parameters, are better predictors of clinical outcome, and ...
48.
MH002795 (2010) Preclinical Evaluation Of PET Radiotracers
Robert Innis, MD
Examples of progress made during the prior year are summarized below.
1) We demonstrated in rats that PET can measure the activation status of an enzyme that may be involved in depression (Itoh et al., 2010.
The 3',5'-cyclic adenosine monophosphate (cAMP) cascade is a major signal transduction ...
49.
MH002797 (2010) Neuronal avalanches in the neocortex
Dietmar Plenz, PhD
During the last year, we made 4 major advances in neuronal avalanche research:
1. We demonstrated that from the scale-invariant, and threshold-independent neuronal avalanche dynamics arise new, threshold-dependent coherence dynamics that might allow for basic decision-making processes at the popu ...
50.
MH002798 (2010) The Psychophysiology Of Fear And Anxiety
Christian Grillon, PhD
Our objective is to determine the extent to which various aspects of defense mechanisms and conditioned fear are relevant to features of particular forms of normal and abnormal anxiety in humans. We focus not only on the mechanisms underlying fear and anxiety (acquisition, extinction, generalization ...
51.
MH002800 (2010) Identifying Neural Substrates of Behavior in Drosophila Melanogaster
Benjamin H White, PhD
The goal of this research is to exploit techniques for the targeted manipulation of neural activity to identify, and functionally define, brain networks underlying specific behaviors. As a model for such investigations, we are identifying the networks that govern the behavioral program executed by a ...
52.
MH002803 (2010) Magnetic Resonance Spectroscopy and Imaging Studies of Brain Functions
Jun Shen, PhD
The goals of this research are to develop advanced magnetic resonance spectroscopy (MRS) and imaging techniques and to apply them and other complementary methods to studying brain metabolism, neurotransmission and enzyme activity. MRS allows measurement of neurotransmission of glutamate and GABA in ...
53.
MH002804 (2010) Family Study of Affective and Anxiety Spectrum Disorders
Kathleen R Merikangas, PhD
The chief goal of this study is to identify the components of the spectrum of mood disorders using methods of genetic epidemiology, developmental psychopathology and clinical psychiatry/psychology. One of the chief issues addressed in our work is identifying the core clinical and biologic factors un ...
54.
MH002806 (2010) National Comorbidity Survey - Replication (NCS-R)
Kathleen R Merikangas, PhD
During the past year, we have continued to investigate the spectrum of mood disorders and mental-physical comorbidity in this national survey of U.S. adults, and to expand our network of collaborators.
Mood Disorders: The chief issue that was examined in the NCS-R during the past year was the in ...
55.
MH002807 (2010) Zurich Cohort Study of Young Adults
Kathleen R Merikangas, PhD
During the past year, we have continued to analyze this unique longitudinal prospective study of a cohort of young adults who have been followed for 25 years since the age of 18.
We first completed an analysis of the validity of definition of the headache subtypes and examined their prevalence, ...
56.
MH002808 (2010) National Comorbidity Survey - Adolescent (NCS-A)
Kathleen R Merikangas, PhD
During the past year, the major methodological and basic descriptive data have been summarized and submitted for publication. The methodological papers described the NCS-A background and measures (Merikangas et al 2009), study design and sampling (Kessler et al, 2009), field procedures (Kessler et ...
57.
MH002810 (2010) Mapping genes that contribute to bipolar disorder
Francis Joseph McMahon, MD
In collaboration with 10 academic centers across the United States, we have recruited a large sample of families in which at least 2 siblings suffer from bipolar disorder or related mood disorders. This is the largest sample ever to participate in a genetic study of bipolar disorder. All research pa ...
58.
MH002813 (2010) Cholinergic Modulation of Cognition and Emotion in Mood Disorders
Maura L Furey, PhD; Carlos Alberto Zarate, MD
In addition to pervasive sadness, specific aspects of behavior and cognition are impaired in mood disorders, including selective attention, set-shifting and memory. In addition, depressed individuals exhibit a mood congruent processing bias whereby they more readily process negatively toned informat ...
59.
MH002826 (2010) Control of Fear/Defensive Behavior by Brain Derived Neurotrophic Factor
Alexei Y Morozov, PhD
The main goal of this project is to understand how changes in the hippocampus may cause pathological aggression. We have previously found that mice with the conditional knockout (KO) of Brain Derived Neurotrophic Factor (BDNF) restricted to the hippocampal area CA3 are more aggressive than their wil ...
60.
MH002828 (2010) Antidepressant Efficacy of an Antiglutamatergic Agent in Bipolar Depression
Carlos Alberto Zarate, MD
Preclinical and clinical studies suggest that drugs that modulate the glutamatergic system might result in therapeutic effects in patients with mood disorders. Antidepressants have been demonstrated to have delayed indirect effects on this system. Lamotrigine, an inhibitor of glutamate release, is a ...
61.
MH002831 (2010) AMPA receptor trafficking in the pathophysiology and treatment of mood disorders
Jing Du, MD, PhD; Miles Herkenham, PhD
Mood disorders are one of the leading causes of disability worldwide, ranking ahead of ischemic heart disease, cerebrovascular disease, cancers, and infectious diseases. Despite the devastating impact that mood disorders have on the lives of millions of individuals worldwide, little is known about t ...
62.
MH002832 (2010) Role of adult neurogenesis in regulation of the HPA axis and stress resiliency
Miles Herkenham, PhD
The dentate gyrus of the hippocampus is one of two regions in the brain that retains the capacity to generate new neurons throughout the lifespan. The survival of these newly born neurons is negatively regulated by stress exposure and increased glucocorticoids. Recent studies have proposed that the ...
63.
MH002833 (2010) Investigation of Mitochondrial Function in Bipolar Disorder
Jing Du, MD, PhD; Miles Herkenham, PhD
Lithium and valproate (VPA) are common mood stabilizers for bipolar disorder and are shown to indirectly regulate intracellular pathways, using molecules like cAMP response element-binding protein (CREB), brain derived neurotrophic factor (BDNF), Bcl-2, and mitogen-activated protein kinases (MAPK), ...
64.
MH002835 (2010) Neuronal-Glial Interaction in the Treatment of Bipolar Disorder
Jing Du, MD, PhD; Miles Herkenham, PhD
Pro-inflammatory cytokines, such as Tumor Necrosis Factor-alpha (TNFalpha), Interlukin-1 (IL-1) and Interlukin-6 (IL-6), were first discovered in the context of cellular activation and cell-to-cell communication in the immune system. Early studies on the role of cytokines in the brain suggested that ...
65.
MH002838 (2010) Neurophysiology of Visual Perception
David A Leopold, PhD
The mysteries of visual perception are a fascination for neuroscientists and non-neuroscientists alike. Why do we have conscious awareness and how does it come about? Philosophers have so far failed to provide many satisfying answers, and neuroscientists have found the neural basis of awareness eq ...
66.
MH002840 (2010) Glucocorticoid Receptors (GR) in Mitochondria: The Role in Chronic Stress
Jing Du, MD, PhD; Miles Herkenham, PhD
Chronic stress has been shown to be associated clinically with formation of depression in patients and hormones are known to mediate certain clinical manifestations of mood disorders. Chronic restraint stress induces a morphological reorganization of neurons in certain areas of rodent brain, effects ...
67.
MH002841 (2010) Testing whether the enzyme GSK-3 is a therapeutically relevant target of lithium
Jing Du, MD, PhD; Miles Herkenham, PhD
The mood stabilizer lithium inhibits a select group of enzymes, including glycogen synthase kinase-3 (GSK-3). However, it is unclear if lithium inhibition of GSK-3 is relevant for its antimanic and antidepressant effectiveness. We are utilizing biochemical, cellular, histochemical, genomic, and beha ...
68.
MH002842 (2010) A Collaborative Genomic Study of Bipolar Disorder
Francis Joseph McMahon, MD
Since 1988 the NIMH Genetics Initiative has supported a national resource for the study of bipolar disorder (BP). This extension of the national genetic resource includes a sample of over 2000 unrelated BP probands, over 1000 affected siblings, and available parents for case-control and family-based ...
69.
MH002843 (2010) Genetic Linkage and Association in Bipolar Disorder
Francis Joseph McMahon, MD
This collaboration has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically-based hypotheses about the genetic heterogeneity of the illness. We have ascertained and assessed about 150 nuclear families with a bipolar I proband and two or more sibl ...
70.
MH002844 (2010) Genetic Determinants of Antidepressant Response in the STAR*D Cohort
Francis Joseph McMahon, MD
Strong evidence from family and twin studies demonstrates that major depressive disorder (MDD) is heritable, yet there has been limited progress in identifying the actual genes involved. A separate, perhaps overlapping set of genes is expected to play a role in individual variation in treatment resp ...
71.
MH002845 (2010) In vivo Analysis of Mouse in which Genetic Mutation is Targeted to CA3 Cells
Kazutoshi Nakazawa, MD, PhD
We had two projects to investigate the role of CA3 in the pathology of CA1 excitotoxic cell death and of chronic stress, using CA3-NR1 KO mutants in which the essential NR1 subunit (GluN1) of the NMDA receptor is selectively eliminated from CA3 pyramidal neurons (Nakazawa et al., 2002). First, we h ...
72.
MH002846 (2010) Generation and Analysis of Genetic Protein Synthesis Knockdown Mice
Kazutoshi Nakazawa, MD, PhD
Reversible phosphorylation of subunit of eIF2 on Ser51 is one of the best characterized rate-limiting steps at the translational initiation level, and it controls the rates of both gene-specific translation and general translation. Ser51 phosphorylation of eIF2 precludes formation of eIF2GTPMet-tR ...
73.
MH002851 (2010) Generalized Anxiety Disorder and Social Anxiety Disorder:
Robert James Richard Blair, PhD
There are three important strands to our work with patients with GSP and GAD. The first of these strands is determining the degree to which the pathology seen in GAD differs from that seen in GSP. In the first study of its kind, we presented patients with GSP, patients with GAD, patients with both ...
74.
MH002852 (2010) Clinical Evaluation of PET Radiotracers
Robert Innis, MD
Examples of progress made during the prior year are summarized below.
1) We compared in monkeys and humans two radioligands that may be able to measure inflammation in the brain and found that our more recently developed radioligand has much greater specific signal (Kreisl et al., NeuroImage, 201 ...
75.
MH002857 (2010) Glutamatergic Modulators for Rapid & Sustained Antidepressant Effect
Carlos Alberto Zarate, MD
Recent preclinical and clinical studies suggest that the glutamatergic system is involved in the mechanism of action of antidepressants. We found that the non-competitive NMDA antagonist (ketamine) was effective in treatment-resistant major depression. Ketamine resulted in rapid, robust and relative ...
76.
MH002860 (2010) Emotional dysfunction and childhood behavioral disturbance
Robert James Richard Blair, PhD
In previous work, we primarily used neuropsychological investigations to determine the functional impairments associated with CD+CU. We identified that adolescents with this disorder showed marked difficulties with: (1) the processing of fearful expressions. Youth with CD+CU show impaired recogniti ...
77.
MH002862 (2010) The role of serotonin in emotional processing
Robert James Richard Blair, PhD
Our work thus far has investigated the effects of altering serotonergic systems in humans using acute tryptophan depletion on behavioral performance during emotional processing tasks. Additionally, we have begun to determine how acute tryptophan depletions effects on emotional processing vary as a ...
78.
MH002863 (2010) Multimodal Neuroimaging of Gene-Brain Relationships in Williams Syndrome
Karen F Berman, MD
As discussed extensively in Eisenberg et al. (NeuroImage, 2010), investigation of the neurobiology of Williams Syndrome (WS), a condition with a well-defined causitive microdeletion and characteristic neuropsychiatric manifestations, poses a unique opportunity to understand the genetic foundations o ...
79.
MH002865 (2010) Reproductive Endocrine Related Mood Disorders-Differential Sensitivity
Peter J Schmidt, MD
In our earlier studies we have developed experimental models for the triggering of symptoms in both premenstrual dysphoric disorder (PMD) and postpartum depression that we continue to employ in our efforts to identify both the underlying biology of these conditions as well as the development of ne ...
80.
MH002868 (2010) Clinical and Behavioral Phenotyping of Autism and Related Disorders
Susan Elizabeth Swedo, MD
Autism is defined as a single disorder characterized by impairments in communication and social interaction and the presence of restricted interests and repetitive behaviors. The current diagnostic definition is based on behavioral characteristics, but there is mounting evidence that autism may rep ...
81.
MH002869 (2010) Characterization of Dentate Mossy Cell-restricted Genetic Manipulation Mice
Kazutoshi Nakazawa, MD, PhD
Project #1: Elimination of mossy cell NMDA receptors results in impaired neurogenesis.
Previously, we subjected mossy cell NR1-KO mice and their control littermates to a battery of behavioral tasks including fear conditioning, a task that involves associating a particular context with an aversive s ...
82.
MH002870 (2010) National Health And Nutrition Examination Survey (NHANES)
Kathleen R Merikangas, PhD
During the past year we have completed extensive analyses of the data from both the child and adult components of the NHANES surveys and have published several papers. First, we reported the first prevalence rates and demographic correlates of DSM-IV disorders in a nationally representative sample o ...
83.
MH002874 (2010) The Neuroregulatory Effects of Gonadal Steroids in Humans
Peter J Schmidt, MD
In our earlier studies of regional cerebral blood flow using PET, we reported for the first time in humans that induced hypogonadism was associated with the elimination of the normal pattern of cortical activation in the dorsolateral prefrontal cortex as well as in the posterior inferior temporal co ...
84.
MH002881 (2010) Molecular mechanisms of synapse development and plasticity
Zheng Li, PhD
1. By using caspase-3 knockout mice, we demonstrated that caspse-3 activated by mitochondria is required for induction of NMDA receptor-dependent LTD and AMPA receptor endocytosis (Li et al., Cell 2010). Furthermore, by combining gene knockdown and knockout approaches, we show that activation of BAD ...
85.
MH002882 (2010) Characterization of miRNAs on neural development and plasticity
Zheng Li, PhD
miRNAs regulate protein synthesis by suppressing translation or destabilizing mRNAs. Their role in development and function of the nervous system is not well understood. This year, we identified a miRNA that regulates the development and function of synapses in the hippocampus. We have also determi ...
86.
MH002886 (2010) Neural mechanisms of reward processing and emotion
Elisabeth Adams Murray, PhD
Neuropsychological investigations of the prefrontal cortex have shown a clear role for both PFo and PFm in reward-guided behavior and emotion (Izquierdo and Murray 2004; Izquierdo et al., 2005). Damage in either area leads to altered emotion and social behavior as well as disrupted autonomic respons ...
87.
MH002887 (2010) Neural substrates of reward processing and emotion
Elisabeth Adams Murray, PhD
Previous work on this project has demonstrated that reward-based decision making requires direct functional interaction between the amygdala and PFo. Given the importance of flexible, value-based decision making in cognition, we explored whether functional interactions with additional brain structur ...
88.
MH002890 (2010) Integrating EEG/MEG and fMRI: 99-M-0172
Richard Coppola, SB, DSc
Development of MEG data recording and signal processing methods has been very successful. Studies of working memory tasks and auditory processing tasks have shown the ability to localize brain activation and to address issues of phasic versus tonic activity. We are investigating phenotype measures t ...
89.
MH002892 (2010) Synaptic mechanisms of amygdala-dependent behaviors
Alexei Y Morozov, PhD
Fear behaviors serve to protect the organism from dangers, but they can become maladaptive during mental illness. Amygdala is the main area of the brain responsible for control of fear behaviors, and we are trying to understand how its synaptic properties relate to its fear-regulating functions in n ...
90.
MH002893 (2010) Learning and plasticity in the human brain
Christopher Ian Baker, PhD
The primary goals of this research are i) to establish the changes in brain processing arising from nervous system damage or dysfunction, ii) to understand how brain plasticity contributes to these changes, and iii) to determine how learning may ameliorate the negative consequences of such changes. ...
91.
MH002895 (2010) Forebrain GABAergic cell-selective genetic manipulation in mice
Kazutoshi Nakazawa, MD, PhD
Previously, we confirmed that genetic elimination of the NR1 subunit of NMDA receptors in Ppp1r2-Cre/NR1 KO mutant mouse line begins at postnatal day 7 and is targeted to 40-50% of cortical and hippocampal GABAergic cells, primarily parvalbumin positive ones. We then conducted an extensive battery o ...
92.
MH002896 (2010) The Neural Basis of Functional MRI Responses
David A Leopold, PhD
The Intramural Reseaerch Program at the NIMH is one of only a handful of sites in the world in which neural activity can be compared directly with simultaneously and/or sequentially recorded fMRI signals. We have integrated electrophysiology and imaging in alert, behaving monkeys by collaborating w ...
93.
MH002897 (2010) Molecular and Cellular Mechanisms of Experience-Dependent Cortical Processing
Kuan Hong Wang, PhD
Scientists understand that it takes multiple encounters for mammalian synapses to form long-term partnerships. During development, the potential synaptic partners interact to determine which partners are the best matches. The presynaptic axon and the postsynaptic dendrites must have the right physi ...
94.
MH002898 (2010) Visual Adaptation and Neuronal Selectivity
David A Leopold, PhD
It is now possible to design computers that compute millions of calculations per second, perform useful tasks, and recognize objects. However, despite these advances, computers fall short of emulating brain function in the domain of flexibility. One of the remarkable aspects of the brain is that i ...
95.
MH002904 (2010) Biological Characterization of Genetic Mechanisms in Neuropsychiatric Disorders
Daniel R. Weinberger, MD
It is widely assumed that risk for most common medical disorders, especially for psychiatric disorders, involves interactions between multiple genes and between genes and the environment. Methods for testing and confirming epistasis in clinical samples, particularly the higher order interactions lik ...
96.
MH002907 (2010) Blood Genomics and Cell Model Approaches for Neuropsychiatric Disorders
Daniel R. Weinberger, MD
A gene recently implicated in dopamine intracellular signaling through D2 receptors is AKT1 (v-akt murine thymoma viral oncogene homolog 1). Decreased AKT1 protein levels have been observed in B lymphoblasts in the postmortem prefrontal cortices of patients with schizophrenia furthering the possibil ...
97.
MH002909 (2010) Object, face and body representations in the human brain
Christopher Ian Baker, PhD
The goal of this research is to understand how we see what we see: how does the brain analyze the light falling on the retina of the eye to encode a world full of objects, people and things?
During the past year we have completed two projects investigating the neural representations of faces/bod ...
98.
MH002910 (2010) Role of the p75NTR, LTD and the cholinergic system in mediating coping mechanism
Miles Herkenham, PhD
The cellular and molecular mechanisms underlying development of depressive and anxiety disorders remain largely unknown. Psychological stress has been shown to contribute to the development of anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD). One ...
99.
MH002913 (2010) Trial of a Glutamate Antagonist in the Treatment of OCD and Autistic Disorders
Susan Elizabeth Swedo, MD
Autism spectrum disorders (ASD) are reported to affect as many as 1 in 150 children, with lifelong disabilities affecting social, communication and psychological functioning. With millions of children affected, ASD represents a tremendous public health problem. Compound the ASD symptoms with medica ...
100.
MH002914 (2010) Treatment of Medical Conditions among Individuals with Autism Spectrum Disorders
Susan Elizabeth Swedo, MD
Autism spectrum disorders are defined by deficits of communication and socialization and the presence of restrictive and/or repetitive behaviors. Recent epidemiologic studies have documented an increase in the number of children identified with autism spectrum disorder (ASD) over the past decade and ...
101.
MH002915 (2010) Neuroimmunologic Investigations of Autism Spectrum Disorders (ASD)
Susan Elizabeth Swedo, MD
Autism is defined by its behavioral manifestations: social deficits, impairments in communication and the presence of restricted or repetitive behaviors. The cause of these abnormalities is unknown, but it is strongly suspected that autism spectrum disorders (ASD) result from a combination of gen ...
102.
MH002917 (2010) Office of the Scientific Director
Richard Nakamura
The NIMH Division of Intramural Research (DIR) scientists conduct research ranging from studies into the mechanisms of normal brain function, conducted at the behavioral, systems, cellular, and molecular levels, to clinical investigations into the diagnosis, treatment and prevention of mental illnes ...
103.
MH002918 (2010) Functional Anatomy of Face Processing in the Primate Brain
Leslie G Ungerleider, PhD
Lesions of the inferior temporal (IT) cortex in humans can result in the clinical syndrome termed prosopagnosia, an inability to recognize familiar faces. Single-cell recordings from the IT cortex of monkeys have revealed the existence of neurons that are selectively activated by visual images of f ...
104.
MH002919 (2010) Subcellular Microdissection for the Identification of Organelle Proteins
Sanford P. Markey, PhD
Microscopic pathology defines many human diseases, but the chemical composition of most histologically observed subcellular structures remains largely uncharacterized. Currently, there is no method for isolating subcellular areas of interest without disrupting the cells and thus distorting naturally ...
105.
MH002920 (2010) The Cognitive Neuroscience of Autism Spectrum Disorders
Alex Martin, PhD
Data collection and analyses have been completed on several behavioral and brain imaging studies of face and object perception, and on social communication and interactions. Our behavioral studies have confirmed that adolescents with ASD have difficulty perceiving specific emotional states from face ...
106.
MH002921 (2010) Molecular regulators of mood and mood disorders
Guang Chen, MD, PhD; Miles Herkenham, PhD
Mood disorders such as bipolar disorder and major depressive disorder have remarkably high prevalence rates in the United States and worldwide. For a large percentage of patients, outcome measures are quite poor, with high rates of suicide, relapse, and residual symptoms (cognitive and functional im ...
107.
MH002922 (2010) Psychiatry Consultation Liaison Service Research
Maryland Pao, MD
The Psychiatric Consultation Liaison Service (PCLS) serves an important integrative function in the NIH Clinical Center. Perceptive clinicians in the NIH intramural research program interact with the PCLS which leads to unique research collaborations in the areas of psychiatric and psychosocial rese ...
108.
MH002927 (2010) Target validation of novel therapeutic agents in mood disorders
Carlos Alberto Zarate, MD
Project 1: Enkephalinergic compounds for major depression: There is increasing evidence that patients with anxious major depressive disorder (AMDD) have a greater depressive severity, functional impairment, increased risk of suicidality, worse social distress, higher incidence of alcohol and drug ab ...
109.
MH002928 (2010) Frontal striatal systems and dopamine in normal and pathological behavior
Bruno B Averbeck
We are still in the preliminary stages of research since moving the lab to the NIMH intramural program in October 2009, so studies are currently incomplete. However, our lab is engaged in collaborations with clinical groups to examine behavior in patients with schizophrenia and Parkinsons disease, ...
Scientific Core
1.
MH002884 (2010) Functional MRI Core Facility
Peter A Bandettini, BS, PhD
Space Utilization:
The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, and 1.5T MRI scanners located within the NMR center and office space on the second floor a ...
2.
MH002888 (2010) Scientific and Statistical Computing Core
Robert Cox, PhD
The main mission of the Core is to help NIH researchers with analyses of their functional MRI (brain activation mapping) data. Along the way, we also help non-NIH investigators. Several levels of help are provided, from short-term immediate aid to long-term development and planning.
Consultation ...
3.
MH002889 (2010) NIMH MEG Core Facility
Richard Coppola, SB, DSc
We have over 50 user accounts representing numerous NIMH, NINDS and NIDCD protocols. There is continual interest from additional groups that are working on protocols and planning studies.
The MEG Core staff has been working interactively with these users in terms of study design, task pr ...
4.
MH002894 (2010) Magnetic Resonance Spectroscopy Core Facility
Jun Shen, PhD
As a noninvasive method for measuring concentration and distribution of chemicals in the living brain MRS is an important tool for studying brain function and disorders. However, robust measurement of MRS signals requires highly sophisticaed design, implementation and maintenance of various MRS tech ...
5.
MH002899 (2010) Neurophysiology Imaging Facility Core: Functional and Structural MRI
David A Leopold, PhD
Two and a half decades ago, visualizing structures in the brain was limited to surgery and suboptimal imaging techniques such as x-ray. Since that time, there have been continual advancements in brain imaging, with the most impressive methods centered upon MRI. MRI, which essentially visualizes th ...
6.
MH002901 (2010) Transgenic animal models for neuroscience research
James M Pickel, AB, PhD
SUMMARY
The potential associations between human genes and mental disorders are being increasingly identified, but with these associations comes a conspicuous lack of understanding of how these genes function in an afflicted, or even a persumably normal brain. By creating animals with the same gene ...
7.
MH002902 (2010) NIMH Non-Human Primate Research Core
James T Winslow
-Assessment of neural and behavioral alterations associated with chronic fluoxetine administration in adolescence.
Summary: A major public health concern has emerged regarding the treatment of children with psychotherapeutic drugs. This study seeks to inform this important concern. A primate diff ...
8.
MH002903 (2010) Procurement and Characterization of Postmortem Brain Tissue
Joel Kleinman, MD, PhD
Since September, 2009 we have collected 88 brains, refined the collection at the request of NIH advisors, and transferred 203 brains tissue specimens to the University of Miami Brain Endowment Bank.
To date, our collection consists of 982 brains
Diagnosis: Schizophrenia 154; Bipolar 56; Major ...
9.
MH002905 (2010) Neuroimaging Core Facility
Venkata S. Mattay, MD; Daniel R. Weinberger, MD
The GCAP Neuroimaging Core implements quality control procedures, optimizes and updates imaging protocols, and collects all clinical imaging data from the CBDB sibling and inpatient studies, and maintains and analyzes all structural, spectroscopy, DTI, and large scale archival fMRI data used in thes ...
10.
MH002906 (2010) Transgenic Mouse and Cellular Models to Characterize Mental Disorders
Jingshan Chen; Daniel R. Weinberger, MD
Our studies of mice with COMT genetic variations are used to test hypotheses about extracellular and intracellular mechanisms influenced by dopamine and related to schizophrenia. Our studies have resulted in proposed neural and molecular mechanisms accounting for the diverse pattern of clinical asso ...
11.
MH002908 (2010) Genetics and Bioinformatics Core Laboratory
Richard Straub, PhD; Daniel R. Weinberger, MD
Our group aims to use evidence of genetic association with measures of brain development and function as a basis for further characterization of molecular pathways. One study which demonstrates this is looking at the genetic protection in healthy siblings of subjects with schizophrenia. Through the ...
12.
MH002911 (2010) NIMH Instrumentation Core Facility
George Raphael Dold, MME, BSEE
This past year, our Section had the unique opportunity to support the research from more than 57 different Labs & Sections within NIMH, NINDS and NICHD. During the past twelve months, investigators from these labs and branches requested 513 formal projects from our staff. Each of these requests was ...
Clinical Support Services
1.
MH002912 (2010) Office of the Clinical Director
Maryland Pao, MD
I. NIMH DIRP CLINICAL SUPPORT SERVICES: The NIMH DIRP Office of the Clinical Director (OCD) coordinates a range of clinical, administrative, and research-related support services to the Institute and Scientific Director including: 1) administrative oversight of NIMH inpatient units and outpatient cl ...
Animal Research Infrastructure
1.
MH002924 (2010) Veterinary Medicine Research Branch
James Raber, DVM, PhD
The NIMH Veterinary Medicine Research Branch (VMRB) has successfully provided support to veterinary medical, husbandry and research support to over thirty-two (32) principal investigators in the NIMH IRP with over eighty-six (86) active animal study protocols. In addition, the Branch has provided tr ...
Education and Outreach
1.
MH002916 (2010) Office Of Fellowship Training
Barry Bernard Kaplan, PhD
An Executive Summary of the full length Annual Report is provided below.
The Office of Fellowship Training (OFT) organized and managed several educational events and programs for the DIRP and the extramural research communities. These events, geared to service the needs of a multidisciplinary basi ...
Technology Transfer
1.
MH002925 (2010) Office of Technology Transfer
Suzanne L Winfield, PhD; Richard Nakamura
The Office of Technology Transfer (OTT) negotiates Material Transfer Agreements, Cooperative Research Development Agreements, Confidential Agreements, Clinical Trial Agreements, etc. We also provide guidance and assistance to NIMH researchers, evaluate employee inventions for their patentability and ...


Two heads are better than one
July 17, 2015
Pairing
I felt that pairing with another person on challenges was beneficial in every instance. Before pairing, I worried about cases where two people did not have the same level of knowledge. When I actually started to pair, I realized that no matter what level the other person is at, you will still end up in a better position than you were before.
If one person has a better understanding of the topic, they could reinforce their understanding by going at a slower pace and teaching the other. When you think you know a topic well, you stop trying to learn more. When you explain to someone else, that other person might have questions that you haven't considered yet. The person with less understanding benefits as well as since they can discuss what they do not understand. The other person may have had the same problems when learning the topic themselves. This give-take cycle works well especially in the empathetic environment that DBC created.
Feedback
What drew me to Dev Bootcamp was watching the Emotional Intelligence video. I was looking forward to learning in an honest environment and getting feedback. When I started getting feedback on my pairing session, I enjoyed reading them and finding out what people thought about the way I worked.
Although most feedback was positive, I did get a bad one. Receiving negative feedback was definitely a lot tougher than I had thought it would be. In a feedback my pair stated that they had felt ignored. At first I felt attacked as I had thought I was being mindful. I immediately thought about what that pair had done that I didn't like. But after that initial response, I thought about why I might have gotten that negative comment in the first place. It made me realize that I needed to be more aware of my pair. It really taught me that it is okay to slow things down because the importance of each challenge isn't that we get the right answer but that we learned from doing it.


Day 1 - Pull to refresh
Photo Sharing App
Design and prototype a “pull to refresh” experience for a photo sharing app.
Day 2 - Drag Rearrange
Photography Portfolio Website
Design and prototype a “drag to rearrange” web experience for a photo or image grid.
Day 3 - Dimmer
Smart Home Automation App
Design and prototype the user experience for dimming a smart bulb on a smart home mobile app. How can the user access and control the bulb?
Day 5 - Sending Cash
Smart Watch App
Design and prototype a smart watch app for sending cash.


This package is capable of intefacing with the open souce Asteisk PBX via its built in Manage API. This will allow you to execute manage commands fo administation and maintenance of the seve.
PHP vesion 5
| Class | Desciption | AsteiskManage | Class fo accessing the Asteisk Manage inteface http://www.voip-info.og/wiki/view/Asteisk+manage+API |
|---|
Documentation geneated on Fi, 21 Ma 2008 15:36:30 +0000 by phpDocumento 1.4.1


PRINTFor the fig swirl: Melt butter over medium heat in a saucespan. Add brown sugar and stir to dissolve. Halve all of the figs and toss in the saucepan with water and lemon juice. Cook over medium heat, stirring frequently, until you have a chunky-jammy mixture. Add salt with on eor two stirs, set aside and let cool completely. Ice cream: In a small pot over medium heat, combine milk, and granulated sugar until sugar is completely dissolved and the milk is just barely lukewarm. Whisk in the egg yolks. Set mixture in the fridge and wait until the fig mixture is cooled. Using an ice cream machine, poor liquids into the frozen basin and process according to manufacturer instructions, i.e., let spin and thicken for 20 minutes before adding mascarpone, fig jam mixture, and the nuts. Continue to process for +/-10 minutes. Pour semi-frozen mixture into a pyrex dish or glass tupperware. Freeze for at least two hours before serving.


State asks public not to swim or snorkel in 7 new anchialine pools on Big Isle | Honolulu Star-Advertiser
In addition to the expansive, black sand beach that has formed at Pohoiki on Hawaii island, state officials say there are now seven new anchialine pools.
State biologists noted at least seven anchialine pools dotting the popular beach along the Puna coastline, also the site of a former boat ramp surrounded by lava during the 2018 Kilauea eruption.
Anchialine pools, according to state aquatic biologist Troy Sakihara, are landlocked, brackish water pools that are still connected underground to the ocean and groundwater. The pools fluctuate with the tides and are home to an array of endemic species found only in Hawaii.
Opaeʻula, or tiny Hawaiian red shrimp, are most commonly found in anchialine pools. The shrimp are popular in desktop aquariums and are noted for their ability to evolve and thrive in a variety of habitats like volcanic rock and sand.
While biologists say they are not surprised that opaeʻula and other native shrimp are beginning to show up at Pohoiki, where and how they got there still remains a mystery.
State officials, however, are reminding the public to respect the new life thriving in the pools by not snorkeling or swimming in them, and minimizing interactions with them.
One woman was recently spotted floating in one of the anchialine pools, with a snorkel, for more than an hour.
“We want to educate folks and ask them not to disturb these pools and minimize their interactions with them,” said Hawaii Division of Aquatic Resources administrator Brian Neilson in a news release. “Please don’t swim or snorkel in them, as you may be killing some of the most endangered aquatic creatures in the state. Respect them and enjoy them, with your eyes, only.”
The pools are valuable resources, ecologically, biologically and culturally, according to Neilson.
“Our team is currently working on a rules package to provide better management strategies for anchialine pools,” he said. “One of the things people can do right now is to stay out of these sensitive areas. Sunscreens and other body oils can degrade water quality and potentially kill creatures like the opaeula.”
Anchialine pools are historically a critical sources of fresh water, particularly in arid regions, officials said. Hawaii is home to an estimated 600 anchialine pools.


code {{ error['code'] }}
error {{ error['error'] }}
Your are logged in as:
{{ json.dumps(handler.current_user, indent=4) }}
You are not logged in.
{% end %}Your session expires in {{ '{:,.0f}'.format(handler.session['_t'] - time.time()) }} seconds
This example shows how you can use a checkbox to implement the "Remember
me" scenario. You can log in below as alpha
with password
alpha
or as beta
with the password
beta
. The session will expire based on the duration you pick
below.
By default, the user is logged in for 1 day. When the user checks the "Remember me" box, they are logged in for 1 month.
You can log in below as alpha
with password
alpha
or as beta
with the password
beta
. The session will expire based on the duration you pick
below.


{% extends 'base.html' %} {% extends 'base.html' %} {% load static %} {% block body_block %}
Circa uses Stripe for all payment-related tasks. Stripe powers payments for many popular products and companies such as Kickstarter, Lyft, and Instacart. We use Stripe to electronically transfer money to people who sell stuff on Circa. Connect or create your Stripe account and start getting paid!


Devoxx 2013
Adil Akther
Jesper de Jong
Gertjan Assies
13-15 November 2013
Adil Akther
Jesper de Jong
Gertjan Assies
13-15 November 2013
(definst dubstep [freq 100 wobble-freq 2] (let [sweep (lin-exp (lf-saw wobble-freq) -1 1 40 5000) son (mix (saw (* freq [0.99 1 1.01])))] (lpf son sweep)))
Its more and more about data, devices talking to each other with human intervention
//Local Actor
val greeterActor = system.actorOf(new Props[GreeterActor](), name="Greeter")
greetActor ! Hello("Gertjan")
//Remote Actor
val greeterActor = system.actorOf(new Props[GreeterActor](), name="Greeter")
greetActor ! Hello("Gertjan")
akka { actor { deployment { /Greeter { remote = akka://MySystem@machine1:2552 } } } }
class Supervisor extends Actor { override val supervisorStrategy = OneForOneStrategy(maxNrOfRetries = 10, withinTimeRange = 1 minute) { case _ : ArithmeticException => Resume case _ : NullPointerException => Restart case _ : Exception => Escalate } }
| Library | Language | Company |
|---|---|---|
| Akka | Scala, Java | Typesafe |
| Play Framework | Scala, Java | Typesafe |
| RxJava | Java | Netflix |
| Reactor | Java | Springsource |
| Reactive Extensions | .Net | Microsoft |
| Node.js | Javascript | Joyent |
def first() = {
Try(Console.readline("add a nr:")
}
def second() = {
Try(Console.readline("add a nr:")
}
def sum:Try[Int] = {
for (
i <- first
j <- second
} yield i.toInt + j.toInt
}
Functional design
Pattern matching
http://presentation-gassies.rhcloud.com/Devoxx2013.html
https://code.google.com/p/html5slides/


GUI: Rackspace Cloud Control Panel¶
The Rackspace Cloud Control Panel is the easiest way to start provisioning cloud resources.
The Cloud Control Panel provides a simple, unified, web-based interface that works in all major browsers. After you sign up for a Cloud account at www.rackspace.com, visit the Cloud Control Panel to get an overview of the available products and services, create your first servers and resources, and view information about your Rackspace account.
To learn about how to use the Cloud Control Panel, start at the Rackspace Core Infrastructure User Guide.
For more information on using the Cloud Control Panel to interact with a specific cloud service, see:
- Cloud Block Storage and the Cloud Control Panel
- Cloud Files and the Cloud Control Panel
- Rackspace CDN and the Cloud Control Panel


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Collection View is in part an extension of my work on Search Workbench. Just as that project enables one to visualize PubMed results, Collection View allows you to visualize your Library of Congress searches so that you can get a better sense of what they are doing. Importantly, you can also directly compare searches to one another — facilitating the process of fine-tuning a search strategy.
Collection View summarizes your search results by plotting them on a couple of different data visualizations. In the first, raw numbers for each format are visualized as a stacked bar graph. In the second, searches using Boolean logic are visualized using a Venn diagram. This view is also available when you're comparing multiple searches. Finally, the proportions of items in your search for each format and each century are compared to the baselines for the collection as a whole.
For more details, check out my talk at Code4Lib 2021. Slides at osf.io. Video on YouTube.
Collection View is put together with JavaScript and jQuery. Search results are fetched with the Library of Congress's API.
Google Charts is used to draw the line charts, and Ben Fredrickson's venn.js overlay of Mike Bostock's d3.js performs the set visualization. Responsive layout is made easier with Bootstrap.
You can find the source code for this application at GitHub.
PubMed by Year is a project of Ed Sperr, M.L.I.S.
Ed can be reached at<EMAIL_ADDRESS>or<EMAIL_ADDRESS>Please feel free to reach out with any comments or enhancement requests!
Copyright 2021, Ed Sperr. This software is provided under the terms of the MIT License. Feel free to borrow/adapt the source code as you wish, but be aware that things strictly adhere to the XKCD Code Quality Guidelines.
Please note that the information provided here comes ultimately from the Library of Congress and is subject to use according to their Legal terms and policies.
Feel free to use this tool as you wish, but if you use Collection View for publication, I'd appreciate a citation:
Sperr E. Collection View [Internet]. 2021 [cited your_date_here]. Available from https://esperr.github.io/collection-view/
Curious about how these techniques can be used for other databases? Check out the PubVenn, PubMed by Year and other cool tools at Visualizing PubMed.


HTML stands for Hypertext Markup Language. It is made up of text content (what you see), markup (what it looks like), and references to other documents (e.g. images).
The web works by a person going to a web page like Google. The computer sends a HTTP request to a server. The server finds the appropriate HTML document and sends back to the user's computer where the web browser interprets the page and displays it on the user's eescreen.
HTML documents are made of HTML elements. HTML elements are made up of an opening tag, contents, and closing tag. When writing HTML, we tell browsers the type of each element by using HTML tags.
A place were we can play around with how our markup language appears with is the
Udacity Playground.
DOM stands for Document Object Model. DOM is a standard convention for representing and interacting with elements in HTML. Each HTML tag creates an element in the DOM that the browser uses to display the page.
 Humans tell computers what to do, so we have to be careful about mistakes.
Inline elements include <br> and <em> tags which apply to the content inside that tag. Block elements are used to create "invisible boxes" around the content inside of them. Examples of a block element are <div> and <p>.
Types of version control are: Manual Saving, Dropbox, Google Docs, Wikipedia, Git, and SVN. We use Git for the Udacity class.
Git is a version control system. Git allows saving multiple files in one commit, while others, like Google Docs, treat each file separately.
It's easier to break sections up and update as you work.
Repetition only leaves room for errors, especially when you have to repeat it in several different places. The best way is to assign a class for consistency in what you are wanting to repeat. This can be done via a style sheet.
CSS stands for cascading style sheets. It is a style sheet language that describes the look and format of a document written in HTML.
At the present, I do not have many notes on CSS. I've been googling and reviewing YouTube to get a feel for what is expected.
There were 2 sites shared in the forum to check HTML and CSS Coding. There were HTML CODING CHECK which can be used to check the fomat of your HTML coding. for checking the formatting of your HTML coding. CSS CODING CHECK Use this site to verify that your CSS coding is correct.


My Google Maps Demo
How to find location of a user using HTML5 Geolocation?
You are at Latitude: _________, Longitude: _________


 The
N(ext)
and
P(revious)
keys will also work.
Press
Escape
to reveal everything and disable interactivity.
___FRAMS___


Add Pat's Salmon Cookie Stand Location
Projected Location:
Estimated Minimum Hourly Customers:
Estimated Maximum Hourly Customers:
Estimated Cookies Purchased Per Customer:
New Location
Pat's Salmon Cookies
Location Business Tracker
Expected Cookie sales per hour
Minimum employees at each location per hour


E-Book Reader supporting EPUB, PDF, and CBZ formats, with custom fonts and custom dictionary support.
When paired with calibre Content Server, you can easily browse your libraries, download books for reading.
It will also track and sync you reading progress and highlights across all devices paired with the same server.


| A table with one cell and one line. |
| A table with | two columns. |
| A table with | two columns |
| and | two rows. |
| A table with three rows, | |
| and two | columns. |
| [inner block: First and last rows contain column spans.] |
| [inner block: A table with three columns,] | two rows in | [inner block: and row spans to left and right.] |
| the middle, |
| [inner block: A table | with 3 +-- columns,] | two rows in | [inner block: and funny -+ stuff. |] |
| the middle, |
| [inner block: W/NW cell ] | N/NE cell | |
| Middle cell | [inner block: E/SE cell ] | |
| S/SE cell |
| A table with two header rows, | |
|---|---|
| the first | with a span. |
| Two body | rows, |
| the second with a span. |


Mutfunc: SARS-CoV-2
You need JavaScript enabled to run the Mutfunc: SARS-CoV-2 web app.
The site provides an interface to search precalculated variant effect predictions for all possible SARS-CoV-2 protein variants.
SIFT4G Scores, FoldX ΔΔG predictions, FoldX complex interface predictions, phosphosites and observed frequencies are currently provided, as well as tools to view the alignments and protein structures used to calculate them.
The dataset and methods are described fully in PAPER LINK.
The results are also available to download in table form on the Mutfunc FTP.


{% extends "base.html" %} {% block breadcrumb %} Home User Details {% endblock %} {% block contentheader %} User Details {% endblock %} {% block extra_js %} {% endblock %} {% block content %}
The email specified already exist please check your email is correct or speficiy a different email.
Your current password is incorrect. Please enter in your current password correctly.
Confirmed password was not the same as the first Password entered. Please try again.
Password changed!
Changes saved!


--- title: Flex.ly | Front-end style Guide fabricator: true ---
This guide contains code examples of atoms and components.
Start by adding the following files to your page:
<link rel="stylesheet" href="assets/toolkit/styles/toolkit.css">


My 'myelectric' page has suddenly stopped functioning (see screenshot below), no data is shown, and the 'spanner' link is unresponsive, so I cannot access the 'myelectric' config page. Everything else works fine, inputs, feeds dashboards etc.
The only thing that I have changed recently is making some adjustments to the feeds page. Does 'myelectric' handle errors OK - such as 'feed no longer available' ??
If I check my browser developers tools, I see the error;
Uncaught SyntaxError: Unexpected token : myelectric?apikey=527ee7ec14130b874655hg343bghb5e:1
The URL of the page is http://<IP_ADDRESS>/emoncms/myelectric?apikey=527ee7ec14130b874655hg343bghb5e
(there's no :1 at the end)
Paul
(PS - that's not my real API key!)
Re: Myelectric page unresponsive v8.1.2 [SOLVED]
Does it give a line number against the Uncaught SyntaxError: Unexpected token : error?
Re: Myelectric page unresponsive v8.1.2 [SOLVED]
I'm afraid not
Paul
Re: Myelectric page unresponsive v8.1.2 [SOLVED]
Eventually sorted this. As I said in my first post, I had been doing some housekeeping with the feeds, and had deleted & replaced the 'Daily Consumption' feed, which was used as the 'Bar Graph Feed' in Myelectic.
This resulted with a syntax error being created and left me unable to open the 'Myelectric' admin page to change the Bar Graph Feed selected from the drop down.
The only way that I could rectify this was to edit the myelectric table in the MYSQL database using phpMyAdmin and change the Bar Graph Feed to the correct feed ID.
To prevent this type of error, shouldn't there be a check in place to ensure that the feed still exists?
Paul


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Carbonara
Carbonara is a simple dish. The quality of your ingredients make or break it.
I recommend using the best ingredients you can source.
Suggestions: bronze extruded pasta, 24 months aged Parmigiano-Reggiano, 12+ months aged Pecorino Romano, guanciale from the butcher, and organic eggs.
This recipe assumes medium eggs.
- ⏲ Prep time: 5 min
- 🍳 Cook time: 25 min
- 🍽 Servings: 4
Ingredients
- Spaghetti: 320 g | 11 oz
- Eggs: 5
- Guanciale or Smoked Pancetta (cleaned and cubed): 150 g | 5 oz
- Pecorino Romano or Parmigiano-Reggiano (grated)(optional)
Directions
- Crack the eggs in a bowl but only add the yolks. Add a generous amount of your preferred grated cheese (Pecorino or Parmigiano) around 35g (you can optionally add a dash of black pepper).
- Fill a pot with water, and when it boils cook the pasta 1 minute less than advised. Use less salt than you would normally too. (see Pasta)
- Fry the preferred pork (Guanciale or Smoked Pancetta) in a iron or nonstick pan (if using a different kind of pan add a dash of extra virgin olive oil) on low to medium heat until the sides are crisp but the insides are chewy.
- While everything is being cooked and fried, beat the eggs manually using a fork until everything is entirely liquid. Remember to watch the time.
- When your pasta is done (-1 minute), drain it and put it in the bowl with eggs. At this step you may consider the timing: if the pasta is too hot you will cook the eggs, and some people don’t like it this way, so just wait for a minute. Keep moving and stirring to fully incorporate the eggs. Add guanciale and as many fats remaining in the pan as you want. Keep moving and stirring.
- Plate and optionally garnish with the preferred grated cheese and black pepper. Voila.
Contribution
Peter Piontek, Ladislao Blanchi
Recipe tags:
italian
pasta
quick
cheesefare


--- layout: page title: ! 'False data injection attacks in control systems' comments: true ---
Yilin Mo and Bruno Sinopoli
First Workshop on Secure Control Systems, CPS Week, 2010
Link to the paper
This paper analyzes the effects of false data injec-tion attacks on Control System. We assume that the system, equipped with a Kalman filter and LQG con-troller, is used to monitor and control a discrete linear time invariant Gaussian system. We further assume that the system is equipped with a failure detector. An at-tacker wishes to destabilize the system by compromising a subset of sensors and sending corrupted readings to the state estimator. In order to inject fake sensor mea-surements without being detected the attacker needs to carefully design its inputs to fool the failure detector, since abnormal sensor measurements usually trigger an alarm from the failure detector. We will provide a nec-essary and sufficient condition under which the attacker could destabilize the system while successfully bypass-ing the failure detector. A design method for the de-fender to improve the resilience of the CPS against such kind of false data injection attacks is also provided.
The proof of Theorem 2 is not correct. However, the statement is correct. The sketched proof can be found here.
The code is written in Matlab R2009b (<IP_ADDRESS>9).


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The timer will start as soon as you press the first letter.
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VisDA Challenge
Aeroplane
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(Quick Reference)
3.3 Combat - Reference Documentation
Authors:
Version: 0.3.2
3.3 Combat
Combat in Little Goblin currently is the fight between a player character and a monster or,
in the case of the Grand Melee (see below) between all willing player characters. A fight is started
by meeting a monster during a quest encounter. The fight will go on until the player wins, flees or
is defeated.
Combat is round-based. At the moment, the player has the option to
- use items from his or her inventory
- to attack the opponent
- run away
Running away is always successful and terminates the current quest.
Attacking uses the currently equipped weapon(s) and passive abilities to determine the effects
on the opponent.
A closeup of a fight
A round of combat consists of the following steps:
- determine initiative (rolling a d20 at the moment, add bonuses)
- attacker rolls to strike
- defender rolls to parry
- in case of a hit, compute damage from all items that contribute to damage dealt.
- check if both combatants are alive
- counter attack of the defender (strike, parry, deal damage, check result)
- either finish the combat sequence or start a new round
Special damage and mitigation
Items or a creature's natural abilities may deal special damage (for example, a dragon breathing fire).
This is included via a damage multiplier, so a dragon may deal fire damage which increases its base
damage by a factor of 1.2. If this dragon is also for some reason a creature of chaos, it may increase
the damage further by another factor of 1.3. Likewise, the abilities or items of a fighter may reduce
the damage dealt by a certain factor. A ring of protection from chaos may reduce damage with chaotic
influence by a factor of 0.5 (so chaos damage is reduced by 50%).
Note that in this simple combat model an armor of protection from fire will reduce the
total damage,
not the percentage of the damage that is actually dealt be heat. So, attacking a creature that is virtually
immune to fire with a +20 burning sword of fire,death,chaos,poison is not the best strategy.
The Grand Melee
The Grand Melee is Highlander-style combat szenario where all participants will fight each other
until only the winner is left standing. It is round based with a fixed timeout to prevent players
from waiting too long before committing to an action. (If a player does not submit an action,
his character will attack a random opponent).


Preparation time
overnight
Cooking time
30 mins to 1 hour
Toad in the hole is the ultimate comfort food. Use good quality sausages to make it extra special.
Put the flour in a bowl and make a well in the centre. Whisk in the eggs and mustard and continue to whisk until just smooth. Gradually add the milk and a pinch of salt and whisk to a smooth batter. Place in the fridge for at least four hours, but preferably overnight.
Preheat the oven to 220C/200C Fan/Gas 7.
Pour three-quarters of the beef dripping in a roasting tin and heat in the oven. Heat a frying pan and add the remaining dripping. When it’s melted, add the sausages and fry on each side until browned.
Remove the batter from the fridge and whisk once more to combine.
Put the sausages in the roasting tin and pour over the batter. Place in the oven for 30 minutes. Briefly open the oven door to allow the steam to escape and cook for a further 10 minutes.
Meanwhile for the vegetables, put the butter, salt, sugar and 200ml/7fl oz of water in a deep sauté pan. When the butter has melted add the carrots and cook for 3-4 minutes.
Bring a large pot of salted water to the boil, add the peas and cook for 2-3 minutes. Drain the peas and add a little butter.
Heat the veal jus and season with salt and pepper.


Hi ! My name is Shashank Sabhlok. I am currently pursuing Electrical Engineering at the University of Waterloo, and I am in the final semester of my sophomore year. I recently finished my second co-op term as a Software Developer in Test, for Savision in Ottawa. I was responsible for developing unit tests for their latest System's Centre Operations Manager HTML 5 Application, and at the same time write supporting code to repair the bugs I have discovered.
I am extremely passionate about technology and therefore in my spare time, I take the initiative to learn new languages and skills pertaining to hardware, software & electronics. Furthermore, after working at an 'established start-up' recently, I have also taken a liking to business & finance, and as a result not only have I joined the Finance Association at UW, to increase my knowledge in the field but have decided to pursue an option in Mangement Science. When I am not occupied with school or side projects, you will probably find me on the soccer pitch or at home watching a decent match of cricket and playing video games.
My AIM is to be part of a team of engineers, that completely revolutionize technology and therefore have an everlasting impact on the world !
Blockchain Analyst, Deloitte Management Services   ( August 2015 - Present )
Stochiastic Computing Research Assistant, University of Waterloo   ( May 2015 - August 2015)
Quality Assurance Developer, Savision   (January 2015 - April 2015)
IS Analyst, Service Desk, Maple Leaf Foods Inc   (April 2014 - August 2014)
School Prefect, St. Mary's Catholic High School, Dubai   (March 2010 - May 2013)


Willkommen auf Deinem ESP8266 Netwerk
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Welcome to the Unofficial UCSD Computer Science Wiki
Want to add your thoughts? See a class that needs info? Contribute to this wiki! This is not limited to only coursework. Contribute any resources or additional pages you think anyone may find useful! If a page does not exist for a class you have taken, please do us all a favor and make one!
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Deep-learning-assisted detection and segmentation of rib fractures from CT scans:
Development
and validation of FracNet
2 Shanghai Jiao Tong University
3 MoE Key Lab of Artificial Intelligence, AI Institute, Shanghai Jiao Tong University
4 Dianei Technology
5 Huawei Hisilicon
6 Institute of Functional and Molecular Medical Imaging, Fudan University
Abstract
Background:
Diagnosis of rib fractures plays an important role in identifying trauma severity. However, quickly
and precisely identifying the rib fractures in a large number of CT images with increasing number of
patients is a tough task, which is also subject to the qualification of radiologist. We aim at a
clinically applicable automatic system for rib fracture detection and segmentation from CT scans.
Methods:
A total of 7,473 annotated traumatic rib fractures from 900 patients in a single center were
enrolled into our dataset, named RibFrac Dataset, which were annotated with a human-in-the-loop
labeling procedure. We developed a deep learning model, named FracNet, to detect and segment rib
fractures. 720, 60 and 120 patients were randomly split as training cohort, tuning cohort and test
cohort, respectively. Free-Response ROC (FROC) analysis was used to evaluate the sensitivity and
false positives of the detection performance, and Intersection-over-Union (IoU) and Dice Coefficient
(Dice) were used to evaluate the segmentation performance of predicted rib fractures. Observer
studies, including independent human-only study and human-collaboration study, were used to
benchmark the FracNet with human performance and evaluate its clinical applicability. A annotated
subset of RibFrac Dataset, including 420 for training, 60 for tuning and 120 for test, as well as
our code for model training and evaluation, was open to research community to facilitate both
clinical and engineering research.
Findings:
Our method achieved a detection sensitivity of 92.9% with 5.27 false positives per scan and a
segmentation Dice of 71.5%on the test cohort. Human experts achieved much lower false positives per
scan, while underperforming the deep neural networks in terms of detection sensitivities with longer
time in diagnosis. With human-computer collobration, human experts achieved higher detection
sensitivities than human-only or computer-only diagnosis.
Interpretation:
The proposed FracNet provided increasing detection sensitivity of rib fractures with significantly
decreased clinical time consumed, which established a clinically applicable method to assist the
radiologist in clinical practice.
RibFrac Dataset
We collect a large-scale rib fracture CT dataset, named RibFrac Dataset as a benchmark for developping algorithms on rib fracture detection, segmentation and classification. You may access the public part of RibFrac dataset via RibFrac Challenge website after one-click free registeration, which was an official MICCAI 2020 challenge. There is sight difference with the public dataset in this paper and that in the RibFrac Challenge, please refer to the RibFrac Challenge website for details.
| Cohorts | Availability | No. Patients / CT Scans | No. CT Slices | No. Fractures |
|---|---|---|---|---|
| Training | Total | 720 | 265,302 | 6,156 |
| Public | 420 | 154,127 | 3,987 | |
| In-House | 300 | 111,175 | 2,169 | |
| Tuning | Public | 60 | 22,562 | 435 |
| Test | Public | 120 | 44,619 | 882 |
Network Architecture of FracNet
A 3D-UNet-based convolutional neural network, named FracNet, was developed to segment the fractures in a sliding window fashion.
Model Performance
FracNet performs consistently on RibFrac cohorts
Human-computer collaboration
| Detection Performance | Clinical Time | |||
|---|---|---|---|---|
| Sensitivity | Avg FP | Workflow | Average Time | |
| FracNet | 92.9% | 5.27 | Model (31s) | 31s |
| R1 | 79.1% | 1.34 | Diagnosis (322s) + Segmentation (579s) | 901s |
| R2 | 75.9% | 0.92 | Diagnosis (282s) + Segmentation (550s) | 832s |
| R1-FracNet Co. | 93.4% | 1.58 | Model (31s) + FPR (79s) + Segmentation (20s) | 130s |
| R2-FracNet Co. | 94.4% | 1.21 | Model (31s) + FPR (58s) + Segmentation (25s) | 114s |
Citation and License
If you find this project useful, please cite our paper as:
Liang Jin, Jiancheng Yang, Kaiming Kuang, Bingbing Ni, Yiyi Gao, Yingli Sun, Pan Gao, Weiling
Ma, Mingyu Tan, Hui Kang, Jiajun Chen, Ming Li. Deep-Learning-Assisted Detection and
Segmentation of Rib Fractures from CT Scans: Development and Validation of FracNet. EBioMedicine
(2020).
or using bibtex:
@article{ribfrac2020,
title={Deep-Learning-Assisted Detection and Segmentation of Rib Fractures from CT Scans:
Development and Validation of FracNet},
author={Jin, Liang and Yang, Jiancheng and Kuang, Kaiming and Ni, Bingbing and Gao, Yiyi and
Sun, Yingli and Gao, Pan and Ma, Weiling and Tan, Mingyu and Kang, Hui and Chen, Jiajun and Li,
Ming},
journal={EBioMedicine},
year={2020},
publisher={Elsevier}
}
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) License.
Copyright © 2020- RibFrac Team


{% set name = "index" %} {% extends "./_extended_template.html" %} {% block navbar_right %} FAQ {% endblock %} {% block title_content %} Olin.link{% endblock %} {% block subtitle_content %}A URL Shortener for the Olin Community{% endblock %} {% block main_content %}
{% endblock %} {% block additional_content %}https://docs.google.com/document/d/1WLh6RhVyW42e4iyw8OjJp_uu9bLQHZtzrr2XKscvndU/editand turns it into a short one:
https://olin.link/VeryImportantDocumentAs opposed to the long url, the short one is:
bit.ly/OlinShopWorkOrder2
. Because Olin.link is only used
by the Olin community, these sorts of naming conflicts are much less likely.
tinyurl.com/menu
),
you're polluting the global address pool and preventing anybody else
from using that shortlink ever again.
With Olin.link, that's much less likely to be an issue because, for example,
Olin only has one dining hall that only has one menu.
olin.link/menu
can live on forever as the link to the current
dining hall menu, even if the full URL changes.
tinyurl.com/whatever
is boring.
Olin.link/whatever
is cool, unique, and interesting.
<IP_ADDRESS>
is stored in anonymized form as
<IP_ADDRESS>
).


A Better Email Inbox
I am overburdened with how many emails I receive. Everyday I get more and more email. When I first setup my personal email account I didn't think about how many mails I would receive and how often I would receive them.
I also sign-up for a lot of products that startups create, many of which become worthless for me to use. I consistently get many emails that I don't even want to see. The signal to noise ratio of my inbox has become to high to be useful.
Add a Post Fix
The first step in getting your emails to zero is to add a postfix for any new services you sign up for. If you have a Google mail account this is simple to do. All you need to do is append a plus (+) and any text after the email.
Say your email address is<EMAIL_ADDRESS>Your new email that you would use to sign-up for any service is<EMAIL_ADDRESS>In doing this, creating email filters in the future is a breeze. You can setup email filters later on, but for now, make yourself a promise that any new services you sign-up for, you will use this new email address.
Unsubscribing From All the Current Lists
Every time a site asks for your email they are adding you into their distribution list. Who can blame them? You are clearly interested in what they are doing. So, you sign up for the account. After signing up for a few hundred of these, your email becomes out of control.
You need to take back your inbox by unsubscribing from all of these emails.
My process for unsubscribing:
- Evaluate whether I want to continue receiving emails from this company. (The answer should be 99%, no), and then unsubscribe.
- Unsubscribe.
There are two ways you can unsubscribe.
1. Unsubscribe Link
Each email you receive has a link at the bottom of the email that says, "unsubscribe." You can even search for this when looking at an email that has a ton of text.
However, some emails are crafty. They won't use that language, but the link is still at the bottom. An example is the linkedIn email communications.
You will need to do this for a while, but your efforts will be well worth it. Your email stream will become more valuable to you with every email you do this for.
2. Gmail Unsubscribe
Gmail has a really cool unsubscribe feature. It doesn't work for some emails, but in my experience it works 50% of the time. At the top of the email, where it has your name, there will be a drop down button. After clicking this, at the bottom is a link to, "Unsubscribe from this sender."
This is by far the fastest way to unsubscribe.
Relax
This will take a few months of effort, but it will be well worth it. Once finalized you will only receive the emails that you care about. Just put this work flow into your daily email checking and you will begin to see more value in your email box.


Meet Developers
Pavithra Brahmananda Reddy
- Class of 2022
Mina Lee
- Class of 2021
Karen Suzue
- Class of 2022


Unsinkable metal structure mimics spiders and ants
by Bob Marcotte-U. RochesterA new metal structure is so water repellent that it refuses to sink—no matter how often it’s forced into water or how much it’s damaged or punctured.
Could this lead to an unsinkable ship? A wearable flotation device that will still float after a puncture? Electronic monitoring devices that can survive in long term in the ocean?
All of the above, says Chunlei Guo, professor of optics and physics at the University of Rochester.
Spider ‘bells’ and ant ‘rafts’
The structure, inspired by diving bell spiders and rafts of fire ants, uses a groundbreaking technique the lab developed for using femtosecond bursts of lasers to “etch” the surfaces of metals with intricate micro- and nanoscale patterns that trap air and make the surfaces superhydrophobic, or water repellent.
Enter the spiders and fire ants, which can survive long periods under or on the surface of water. How? By trapping air in an enclosed area.
Argyroneta aquatic spiders, for example, create an underwater dome-shaped web—a so-called diving bell— that they fill with air carried from the surface between their super-hydrophobic legs and abdomens. Similarly, fire ants can form a raft by trapping air among their superhydrophobic bodies.
“That was a very interesting inspiration,” Guo says. As the researchers note in the paper: “The key insight is that multifaceted superhydrophobic (SH) surfaces can trap a large air volume, which points towards the possibility of using SH surfaces to create buoyant devices.”
Unsinkable metal structure
Guo’s lab created a structure in which the treated surfaces on two parallel aluminum plates face inward, not outward, so they are enclosed and free from external wear and abrasion. Just the right distance to trap and hold enough air separate the surfaces to keep the structure floating—in essence creating a waterproof compartment.
Even after researchers forced the structures to submerge for two months, they immediately bounced back to the surface after the load released, Guo says. The structures also retained this ability even researchers punctured them multiple times, because air remains trapped in remaining parts of the compartment or adjoining structures.
Etch other metals
Though the team used aluminum for this project, the “etching process “could be used for literally any metals, or other materials,” Guo says.
When the Guo lab first demonstrated the etching technique, it took an hour to pattern a one-inch-by-one-inch area of surface. Now, using lasers seven times as powerful, and faster scanning, the lab has sped up the process, making it more feasible for scaling up for commercial applications.
The paper appears in ACS Applied Materials and Interfaces. Additional coauthors are from the University of Rochester and the Changchun Institute of Optics, Fine Mechanics, and Physics in China.
The Bill & Melinda Gates Foundation, the US Army Research Office, and National Science Foundation funded the work.
Source: University of Rochester