- Journal List
- Br J Clin Pharmacol
- v.55(1); 2003 Jan
- PMC1884190
Lack of effect of ketoconazole on the pharmacokinetics of rosuvastatin in healthy subjects
Abstract
Aims
To examine in vivo the effect of ketoconazole on the pharmacokinetics of rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
Methods
This was a randomized, double-blind, two-way crossover, placebo-controlled trial. Healthy male volunteers (n = 14) received ketoconazole 200 mg or placebo twice daily for 7 days, and rosuvastatin 80 mg was coadministered on day 4 of dosing. Plasma concentrations of rosuvastatin, and active and total HMG-CoA reductase inhibitors were measured up to 96 h postdose.
Results
Following coadministration with ketoconazole, rosuvastatin geometric least square mean AUC(0,t) and Cmax were unchanged compared with placebo (treatment ratios (90% confidence intervals): 1.016 (0.839, 1.230), 0.954 (0.722, 1.260), respectively). Rosuvastatin accounted for essentially all of the circulating active HMG-CoA reductase inhibitors and most (> 85%) of the total inhibitors. Ketoconazole did not affect the proportion of circulating active or total inhibitors accounted for by circulating rosuvastatin.
Conclusions
Ketoconazole did not produce any change in rosuvastatin pharmacokinetics in healthy subjects. The data suggest that neither cytochrome P450 3A4 nor P-gp-mediated transport contributes to the elimination of rosuvastatin.
Introduction
Rosuvastatin (Crestor®) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol biosynthesis, and is effective for the treatment of patients with dyslipidaemia. In clinical trials, rosuvastatin (1-80 mg) produced highly significant dose-dependent reductions in low-density lipoprotein cholesterol (up to 65%) and was well-tolerated [1].
The pharmacokinetics of rosuvastatin following single- and multiple-dose administration of the drug to healthy volunteers have been investigated in several trials ([2] and AstraZeneca data on file [manuscript in preparation]). The absolute oral bioavailability was estimated as 20.1%, which, together with an estimated hepatic extraction ratio of 0.63, implies that absorption was greater than 20%. Systemic exposure was dose proportional over the dose range 10–80 mg, and the elimination half-life was about 20 h.
Elimination of rosuvastatin is primarily via the liver. In a clinical trial [3], 90% of an orally administered dose of 14C-radiolabelled rosuvastatin was recovered in faeces as unchanged drug, a result consistent with metabolism being a minor route of clearance. In vitro studies with human hepatic microsomes and hepatocytes demonstrated only limited metabolism of rosuvastatin [4], and cytochrome P450 2C9 (CYP2C9) appeared to be the principal enzyme involved [4], with minor roles for CYP3A4 and CYP2C19 [4]. In addition, rosuvastatin had no significant inhibitory effect on the major CYP isoforms in human hepatic microsomes [4].
Some of the other HMG-CoA reductase inhibitors (atorvastatin [5], simvastatin [6], and lovastatin [7]) are cleared primarily by metabolism involving CYP3A4. Thus, there is potential for interactions between these compounds and coadministered drugs affecting CYP3A4 activity. It has been shown that the metabolism of atorvastatin [8–10], simvastatin [11, 12], and lovastatin [13, 14] is inhibited by erythromycin and itraconazole, leading to increased serum/plasma drug concentrations and changes in their metabolic profiles.
Although in vitro data suggest that CYP3A4 metabolism is not an important clearance mechanism for rosuvastatin, an in vivo interaction with coadministered drugs that inhibit CYP3A4 cannot be excluded. Accordingly, the present study was conducted to assess the effect of ketoconazole (a potent CYP3A4 inhibitor [15]) on the pharmacokinetics of rosuvastatin.
Ketoconazole is also known to inhibit the activity of transport protein P-glycoprotein (P-gp) [16]. Active- or facilitated-transport processes may have a role in the absorption and disposition of rosuvastatin. Thus, studies with rats have demonstrated selective hepatic uptake of rosuvastatin by an active transport process [17], and rosuvastatin was shown to be a ligand for a liver-specific human organic-anion-transporting polypeptide present in the basolateral membranes of hepatic cells [18], although the identity of these transporters has not yet been clearly defined. Thus, the results of the present study may provide an indication of whether P-gp-mediated transport contributes to rosuvastatin disposition.
Methods
This trial was conducted in accordance with good clinical practice and the Declaration of Helsinki. All volunteers gave written informed consent, and a local independent ethics committee approved the protocol before the trial started.
Trial population
Healthy adult (18–65 years) male volunteers with no clinically relevant conditions identified from their medical history, physical examination, or electrocardiogram (ECG) were included in the trial. Volunteers were excluded if they had any clinically relevant abnormalities in clinical chemistry, haematology, or urinalysis results, or if total bilirubin, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, or creatine kinase were outside the normal reference range at the start of the trial.
Fourteen male Caucasian volunteers were enrolled. Their mean (range) age, height, and weight were 24.1 years (21–31), 182.1 cm (170–189), and 73.5 kg (60–83), respectively. Pharmacokinetic data were available from 13 volunteers [one volunteer withdrew due to personal reasons during the washout period following the first dosing period (rosuvastatin + placebo)]. This withdrawal was considered unlikely to have affected interpretation of the trial data.
Trial design
This randomized, double-blind, two-way crossover, placebo-controlled trial (4522IL/0057) was conducted at a single centre (AstraZeneca R&D, Lund, Sweden). Volunteers were randomized to receive daily oral doses of ketoconazole 400 mg (1 × 200-mg tablet every 12 h) or matching placebo (one tablet every 12 h) for 7 days, with a 2-week washout period between dosing periods. On day 4 of each dosing period, volunteers were given a single oral dose of rosuvastatin 80 mg (1 × 80-mg encapsulated tablet) with the morning dose of ketoconazole or placebo. Volunteers then remained in the Clinical Pharmacology Unit for the following 24 h.
During the trial there were restrictions relating to the consumption of alcohol and physical exercise (none permitted from 96 h before the first dose on day 1 until 96 h after administration of rosuvastatin in each dosing period), the consumption of caffeine-containing drinks/food and smoking (none permitted from midnight before day 1 until 96 h after administration of rosuvastatin in each dosing period), and concomitant medications (none permitted from 96 h before the first dose on day 1 until after the post-trial medical).
Determination of rosuvastatin plasma concentrations
Blood samples (9 ml) for rosuvastatin assay were taken before administration of rosuvastatin on day 4 of each dosing period and 0.5, 1, 2, 3, 4, 5, 6, 8, 10, 12, 18, 24, 30, 48, 54, 72, and 96 h postdose. Additional samples were taken before administration of the first dose of ketoconazole or placebo on day 1 of the second dosing period. Blood samples were collected into tubes containing lithium heparin anticoagulant and centrifuged within 30 min. Plasma was then harvested from the samples, mixed 1:1 with sodium acetate buffer 0.1 m pH 4.0, and stored at −70°C until assay.
Plasma samples were analysed using a validated method (high-performance liquid chromatography with mass-spectrometric detection) at Quintiles Scotland Ltd (Edinburgh, UK) [19]. Briefly, rosuvastatin was extracted from the samples by automated solid-phase extraction on 96-well plates containing a hydrophobic-lipophilic balanced copolymer sorbent using a Genesis RSP100 robotic sample-preparation system (Tecan, Reading, UK). The extract was injected onto a high-performance liquid chromatography column (a Luna column C18(2) 5 µm (4.6 mm i.d. × 150 mm l); the mobile phase was methanol : 0.2% formic acid in distilled water (70 : 30 v/v), and the flow rate was 1 ml min−1). Rosuvastatin was detected using a PE-Sciex API 365 triple quadruple mass spectrometer fitted with a turbo-ionspray source. The lower limit of quantification (LOQ) of rosuvastatin was verified as 0.1 ng ml−1. However, because all samples were diluted two-fold prior to assay, the effective LOQ was 0.2 ng ml−1. The coefficient of variation at the LOQ was ≤ 30%, and at 1 ng ml−1 was ≤ 20%. Correlation coefficients for rosuvastatin calibration curves were 0.996-0.999. Mean imprecision values and inaccuracy levels for quality control samples were < 9% and < 6% (at all concentrations), respectively.
Determination of HMG-CoA reductase inhibitor activity
Two meaningful measures of circulating HMG-CoA reductase inhibitor activity are possible: active inhibitors (the sum of parent compound and active metabolites) and total inhibitors (the sum of parent compound, active metabolites, and inactive lactones). An interacting drug may affect the absolute concentrations of circulating active and/or total inhibitors, and possibly change the contribution of the parent compound to active and/or total inhibition.
The blood samples taken for rosuvastatin assay were also used to obtain plasma for active and total inhibitor assays. Samples were analysed using a validated method (radio-enzyme inhibition assay) at Medical Research Laboratories (Highland Heights, KT, USA). Briefly, drug-related components were isolated from plasma by using acetonitrile : acetone (95 : 5) to precipitate plasma proteins. The supernatant was assayed following hydrolysis (using potassium hydroxide to convert inactive lactones to active acids) for total inhibitors, and unhydrolysed for active inhibitors. The supernatant was evaporated to dryness under nitrogen, reconstituted with distilled water (50 µl), and incubated with buffer solution containing 14C-HMG-CoA cofactors, and HMG-CoA reductase from a human recombinant source. The 14C-mevalonate product of the enzyme reaction was separated from the substrate, after lactonization to 14C-mevalonolactone by hydrochloric acid, on a small ion-exchange column. The effluent from the column (which contained the 14C-mevalonolactone) was collected into scintillation vials and counted. The results were used to construct a standard curve. Concentrations are reported as ng equivalents of rosuvastatin ml−1. The lower LOQ was verified as 0.36 ng ml−1 and the coefficient of variation at the LOQ was ≤ 15%. Mean imprecision values and inaccuracy levels for quality control samples were < 11% and ≤ 16% (at all concentrations), respectively.
Determination of ketoconazole plasma concentrations
Blood samples (10 ml) were taken before and 2 h after administration of the first dose of ketoconazole or placebo on days 4, 5, 6 and 7 of each dosing period. Blood samples were collected into tubes containing EDTA anticoagulant and centrifuged. Plasma was then harvested from the samples and stored at −20°C until assay.
Plasma samples were analysed using a validated method, using high-performance liquid chromatography with fluorescence detection at Phoenix International Life Sciences Inc. (Montreal, Quebec, Canada). The lower LOQ was verified as 20 ng ml−1. Mean accuracy values for quality control samples were 96.5–104.8%, and the imprecision (coefficient of variation) was 1.5–2.5%.
Pharmacokinetic parameters
The primary parameters of this trial were area under the plasma concentration-time curve from time zero to infinity (AUC) and maximum observed plasma drug concentration (Cmax) of rosuvastatin after dosing with ketoconazole compared with placebo. If less than 12 volunteers had AUC data available from both dosing periods, the area under the plasma concentration-time curve from time zero to the time of the last quantifiable concentration [AUC(0,t)] was substituted as a primary parameter for all volunteers. Secondary parameters included time to Cmax (tmax), and terminal elimination half-life (t½) of rosuvastatin, area under the plasma concentration-time curve and Cmax of active and total HMG-CoA reductase inhibitors, and plasma drug concentration of ketoconazole before and 2 h after administration of the first dose on days 4–7.
AUC was determined using the linear trapezoidal rule from time zero to the time of the last quantifiable concentration followed by extrapolation to infinity using the terminal elimination rate constant (λz, calculated by log-linear regression of the terminal portion of the plasma concentration-time curves). AUC(0,t) was determined using the linear trapezoidal rule. Cmax and tmax were determined by visual inspection of the plasma concentration-time curves, t½ was calculated from the expression 0.693/λz.
Statistical methods
The trial had more than 90% power to ensure that the 90% confidence interval (CI) for the treatment ratio (rosuvastatin + ketoconazole/rosuvastatin + placebo) of the geometric least square means (glsmeans) for rosuvastatin AUC [or AUC(0,t)] was contained within the interval of 0.7–1.43 (which represented an increase of 43% or a decrease of 30%). If the 90% CI fell within this prespecified interval, the absence of an interaction was assumed [20].
As rosuvastatin AUC [or AUC(0,t)] and Cmax were the primary parameters upon which sizing of the trial was based, only these were analysed statistically. The parameters were log-transformed and analysed using an analysis of variance model (anova), which accounted for the effects of volunteer, period, and treatment. The results are presented as glsmeans, treatment ratios, and the 90% CIs on the treatment ratios.
Safety assessments
The following safety assessments were performed: adverse event reports, clinical laboratory data (clinical chemistry, haematology, and urinalysis), vital signs, ECGs, and medical examinations.
Results
The geometric mean (gmean) plasma concentrations of rosuvastatin over time were similar when rosuvastatin was coadministered with ketoconazole and placebo (Figure 1). As AUC data from both dosing periods were available for less than 12 volunteers, AUC(0,t) was substituted as a primary parameter and subjected to statistical analysis. AUC(0,t) represented a high proportion (on average 96.8%) of AUC (where it was possible to determine a reliable value), and thus was considered to be a suitable replacement for AUC in the assessment of exposure. Following coadministration with ketoconazole, rosuvastatin glsmean AUC(0,t) and Cmax were unchanged compared with placebo (Table 1). The 90% CIs for the treatment ratios fell within the prespecified interval of 0.7–1.43, so it was concluded that ketoconazole had no effect on the pharmacokinetics of rosuvastatin.
Comparison of areas under the plasma concentration-time curves measured to a common point for rosuvastatin and active and total HMG-CoA reductase inhibitors indicated that, within the accuracy and precision s of the methods used, rosuvastatin accounted for essentially all of the circulating active inhibitors and most (> 85%) of the total inhibitors (Figure 2). The active inhibitors accounted for the majority (≥ 75%) of the total circulating inhibitors (Figure 2). Ketoconazole did not affect the proportion of circulating active or total HMG-CoA reductase inhibitors accounted for by circulating rosuvastatin.
The gmean plasma concentrations of ketoconazole before administration of the first dose on days 4–7 (data not shown) indicated that steady state was achieved before dosing with rosuvastatin and was maintained during sampling. The gmean plasma concentrations of ketoconazole 2 h after administration of the first dose on days 4–7 (4522, 6060, 6060, 5352 ng ml−1, respectively) suggested that concentrations fell within the range anticipated for a 200-mg dose of ketoconazole.
Rosuvastatin and ketoconazole were well tolerated when coadministered. There were no serious adverse events and no clinically relevant changes in clinical laboratory parameters, vital signs, ECGs, or medical examinations during this trial.
Discussion
Coadministration of rosuvastatin and the potent CYP3A4 inhibitor ketoconazole did not produce any change in pharmacokinetics of the former. Furthermore, the results suggest that ketoconazole had no effect on the systemic clearance of rosuvastatin, as individual plasma concentration profiles, including the terminal elimination phase (where defined), were similar between dosing periods.
In contrast to rosuvastatin, atorvastatin [5], simvastatin [6], and lovastatin [7] are cleared primarily by metabolism involving CYP3A4 and are known to interact with CYP3A4 inhibitors [8–14]. The increased circulating concentrations of these HMG-CoA reductase inhibitors reported following coadministration with CYP3A4 inhibitors may enhance the risk for serious adverse events such as skeletal muscle toxicity [12, 14].
Circulating active and total HMG-CoA reductase inhibitor concentrations were measured in this trial. The finding that rosuvastatin accounted for essentially all of the circulating active inhibitors suggests the presence of only a small amount of circulating metabolite(s). The finding that the active inhibitors, and therefore rosuvastatin, constituted the majority of the total inhibitors indicates the presence of only a small proportion of circulating drug-related species with the potential to generate pharmacologically active species (i.e. lactones). These results provide good support for previous data indicating limited metabolism of rosuvastatin [3, 4].
Other HMG-CoA reductase inhibitors have circulating metabolites that contribute significantly to inhibitory activity. Following coadministration with a CYP3A4 inhibitor, the absolute concentrations of HMG-CoA reductase inhibitors and the relative proportions of the parent compound and its metabolites may be affected. For example, in the case of atorvastatin, following coadministration with itraconazole, the mean AUC(0,72) of the active and total inhibitors was increased 1.6- and 1.7-fold, respectively; the mean AUC(0,72) of atorvastatin acid and lactone was increased 3.2- and 4.1-fold, respectively; and the mean AUC(0,72) of the principal metabolite 2-hydroxyatorvastatin acid and its lactone was decreased by 57% and 38%, respectively [10].
There is increasing awareness that drug interactions can also occur as a result of competition for, or induction or inhibition of, transport proteins. Ketoconazole is known to have inhibitory effects on the transport protein P-gp [16]. Active- or facilitated-transport processes may have a role in the absorption and disposition of rosuvastatin [17, 18]. The identity of the rosuvastatin transporters that interact with rosuvastatin has not been clearly defined, but if it were a P-gp substrate, an increase in rosuvastatin exposure would be expected following coadministration with ketoconazole. The potency of ketoconazole to inhibit P-gp has been assessed in cell-based assays and in vivo animal experiments [16]. Based on these data, it is likely that the concentrations of ketoconazole achieved in the present study would have caused a degree of P-gp inhibition [16]. Therefore, our results suggest that rosuvastatin is not a ligand for P-gp. This finding is in agreement with the results of a study that showed no effect of rosuvastatin on the pharmacokinetics of the P-gp substrate digoxin [21].
In conclusion, ketoconazole did not affect the pharmacokinetics of rosuvastatin in healthy subjects. Therefore, coadministration of ketoconazole and rosuvastatin is unlikely to increase the risk of toxicity at therapeutic doses of rosuvastatin. The data suggest that neither cytochrome P450 3A4 nor P-gp-mediated transport contributes to the elimination of rosuvastatin.
Acknowledgments
The authors thank Quintiles Scotland Ltd (Edinburgh, UK) for performing the rosuvastatin assays, Medical Research Laboratories (Highland Heights, Kentucky, USA) for performing the HMG-CoA reductase inhibitor assays, Phoenix International Life Sciences Inc. (Montreal, Quebec, Canada) for performing the ketoconazole assays, Olise M. Nwose MB BS for his support of this trial, and Elizabeth Eaton PhD for manuscript preparation.


WITNESS LIST Finance Committee (Subcommittee on Health & Human Services Demand) February 8, 2002 - 9:00A Amerigroup Texas Providing written testimony: On: Rossberg, Cathy Governmental Relations (Amerigroup Texas), Dripping Springs, TX Health & Human Services Commission ON: Gilbert, Don Commissioner (Health and Human Services Commission), Austin, TX Registering, but not testifying: On: Lorenzen, Steve Director, Rate Setting (Health & Human Services Commission), Austin, TX Legislative Budget Board ON: Furgeson, Kelly Team Manager (Legislative Budget Board), Austin, TX Millard, Nancy Senior Analyst (Legislative Budget Board), Austin, TX Priest, Paul Analyst (Legislative Budget Board), Austin, TX Texas Dept. of Protective & Regulat ON: Chapmond, Thomas Executive Director (Texas Dept. of Protective & Regulatory Services), Austin, TX Hoffman, Richard Board Chair (Texas Dept. of Protective & Regulatory Services), Brownsville, TX Registering, but not testifying: On: Eells, Karen Deputy for Programs (Texas Dept. of Protective & Regulatory Services), Austin, TX Thigpen, Drew Deputy Director of Finance (Texas Dept. of Protective & Regulatory Services), Austin, TX


Sometimes in your game you’ll have to scroll the map when your character moves to some new position. For some games the scrolling creates a really significant part of user experience; I’d recommend to read this article just to understand how important it is.
For your example we’ll take an evil mage animation. Our mage will walk through a long long level that looks like some castle.
The simplest way to implement map scrolling in cocos2d-x is by using the Camera class.
Camera is another Node subclass, so we can use some usual MoveTo action to move it. However, unlike most of the other objects, the camera lives in 3D, so coordinates are specified a bit differently.
That’s how we move the camera to the mage’s position:
cocos2d::Vec2 expectedMagePos; // mage position
<....>
Camera* camera = getDefaultCamera();
const Vec3 currentCameraPos = camera->getPosition3D();
Vec3 newCameraPos = Vec3(expectedMagePos.x, expectedMagePos.y, currentCameraPos.z);
MoveTo* cameraMoveAction = MoveTo::create(1, newCameraPos);
camera->runAction(cameraMoveAction);
Here we create a new position point for the camera; it’s same as the mage position, but also it keeps Z position of the camera.
And that’s all, nothing more. You can see how it works in the demo program. The camera moves each time the mage goes close enough to the right wall:
You could also notice the sceletons here, and there are two important things to say about them. First, some of them move out of the screen borders, so there probably is some waste of CPU resources for calculating their position. You could think it will be better to somehow turn off the animations for all the objects that are too far from the main game character. But this idea is an early optimization, and it’s better to avoid it.
Second, since there are few skeleton persons on the map it will be better to create a special class for a skeleton. Actually, the mage also could use its own class, but to simplify the code I’ve stored all related data in the main class of the scene.
There are two possible ways for creating an object’s class in cocos2d-x:
Both solutions are quite good. Sometimes it comes to more common question “composition over inheritance” and all possible choices have some bad and good sides. Here in the example I’ve used inheritance, but if you prefer composition you can find some useful advices in this article.


Deadline rapidly approaches for embattled Saracens
by By Online EditorsSaracens are expected to drop their appeal against heavy punishments for breaking the Premiership’s salary cap as the deadline for appeal approaches.
The PA news agency understands the English and European champions have decided not to contest the £5.4million fine and 35-point penalty imposed for infractions over the course of the past three seasons.
This marks a change of direction for the club, who had previously indicated they would appeal against the “heavy-handed” sanctions imposed earlier this month.
The news is set to be confirmed today (Monday, 18th November), which is the deadline to serve notice of any appeal.
Director of rugby Mark McCall, however, was unwilling to shed light on the matter as he spoke to media on Sunday.
“Other people in the club are going to make that decision,” McCall told BT Sport as his side opened the defence of their Heineken Champions Cup title with a 30-10 loss to Racing 92 at the Paris La Defense Arena.
“As far as I know the deadline is tomorrow (Monday). My job is very clear and that’s to get on with the rugby and get the very best out of this group.
“This group have done so well for us over the last four weeks and we’re really excited to see how they go again today.”
Pressed on whether he was being consulted on the matter, McCall stressed: “It’s not my decision. It’s a decision for other people in the club.”
The punishments have been suspended pending an appeals process but, if imposed on Monday, Saracens will crash from third in the Premiership to rock bottom on -22 points, 26 adrift of Leicester.
With regard to the fine, which totals exactly £5,360,272.31, it is understood the club will be given a short period of time to make payment.
Saracens, who have won the Premiership for the past two seasons and in four of the past five, boast a number of the game’s elite players.
An independent panel, led by barrister Lord Dyson, found the club had failed to disclose payments to players in each of the 2016-17, 2017-18 and 2018-19 seasons, and had also exceeded the ceiling for payments to senior players.
No details have been revealed on the size of the undisclosed payments or the recipients.


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Social and Ethical Issues
Hardware and Software
Software Development Approaches
Developing software solutions
Defining and understanding the problem
Planning and Designing software solutions
Implementing software solutions (Iteration #1)
- Types of coding errors
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LA PICARONA was my first
design project, which was inspired by 'Doña Segunda' piqueteadero.
Skyart was a project I made in
which I had to take photos, edit and design the website .
Lydian was my mid-career project, which I made with my group during 2019-10.


How long you got...?
During my working life I've had several jobs, I've worked in a factory as a QA and a stand in team leader of which i had this position for 10 months before leaving. I then worked at Mcdonalds for 3 years and even becoming a trainee shift manager in the process. I then moved onto the position I have now, a street care operative for the Hull City council. In all my jobs communication has been key with the public and with my colleagues. I have an extremely strong work ethic and have great time keeping skills. I can work well as part of a team and alone also if I have to. I have a disciplined attitude and great interpersonal skills. I work extremely well under pressure and strive for perfection at every oppurtunity.
I have a little family with my girlfriend and my daughter who mean the world to me. I am a bit of a nerd/geek (if the little snippets were not enough to go on). I love watching football and rugby league in my free time. I've loved tech and ever since being a child, I've loved knowing how things worked whether its a rocket ship or a website I love to learn whats behind the thing we all see. With that in mind and drive due to wanting a career change I've decided to push myself towards web development. At the time of writing this I only know HTML and CSS, however I'm thoroughly enjoying the work I'm doing. Thats what it's all about right?


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iPhone 7 Jet Blcak Reservation System
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made by horipse


This tool turns a Curl command into PHP code. Currently, it knows the following options: -d/--data, -H/--header, -I/--head, -u/--user, and -X/--request. There's probably bugs; please contribute on GitHub!
This script derives from Matt Holt's excellent curl-to-Go.


actionsandpool.pool
public class Swimmer extends SequentialScheduler
Action.ActionState
| Modifier and Type | Field and Description |
|---|---|
protected BasketPool |
baskets |
protected ResourcefulUser<Basket> |
basketUser |
protected CubiclePool |
cubicles |
protected ResourcefulUser<Cubicle> |
cubicleUser |
protected java.lang.String |
name |
protected int |
timeToDress |
protected int |
timeToSwim |
protected int |
timeToUndress |
actionList, currentAction
| Constructor and Description |
|---|
Swimmer(java.lang.String name,
BasketPool baskets,
CubiclePool cubicles,
int timeToUndress,
int timeToSwim,
int timeToDress)
Create a Swimmer
|
| Modifier and Type | Method and Description |
|---|---|
protected void |
init()
add actions that the swimmer has to perform at the swimming pool.
|
reallyDoStep
addAction, doStep, doStepOnCurrentAction, equals, initializeCurrentAction, nextActionUnfinished, removeAction
getState, isFinished, isInProgress, isReady, setState
protected java.lang.String name
protected BasketPool baskets
protected CubiclePool cubicles
protected int timeToUndress
protected int timeToSwim
protected int timeToDress
protected ResourcefulUser<Basket> basketUser
protected ResourcefulUser<Cubicle> cubicleUser
public Swimmer(java.lang.String name, BasketPool baskets, CubiclePool cubicles, int timeToUndress, int timeToSwim, int timeToDress)
name
- the name of the swimmerbaskets
- the baskets administratorcubicles
- the cubicles administratortimeToUndress
- the time it takes to undresstimeToSwim
- the time it take to swimtimeToDress
- the time it takes to dress


Program Info button: The second {_button} in the {_Navigation_bar}, which displays the number of the {_current_program}, and its name if it has one. The text in this button is normally light blue, but turns pink if the program is modified; it is yellow if a {_scratch_program} is selected.
{_long-press Long-pressing} the button displays a {_popup} that allows additional functions to be performed on the current program.


WEEK 20 TUESDAY
Year 1 (Year 2)
FIRST READING Judges 6:11-24
Gideon, go and deliver Israel. Do not I send you? to them.
A reading from the Book of Judges
In those days: The angel of the LORD came and sat under the oak at
Ophrah, which belonged to Joash the Abiezrite, as his son Gideon was beating
out wheat in the wine press, to hide it from the Midianites. And the angel of
the LORD appeared to him and said to him, "The LORD is with you, you
mighty man of valour." And Gideon said to him, "Pray, sir, if the
LORD is with us, why then has all this befallen us? And where are all his
wonderful deeds which our fathers recounted to us, saying, 'Did
not the LORD bring us up from
The word of the Lord
RESPONSORIAL PSALM Psalm 85:9.11-12.13-14 (R. see 9b)
R. The Lord speaks of peace for his people.
I will hear what the Lord God speaks; he speaks of peace for his people
and his faithful, and those who turn their hearts to him.
R. The Lord speaks of peace for his people.
Merciful love and faithfulness have met; justice and peace have kissed.
Faithfulness shall spring from the earth, and justice
look down from heaven.
R. The Lord speaks of peace for his people.
Also the Lord will bestow his bounty, and our earth shall yield its
increase. Justice will march before him, and guide his steps on the way.
R. The Lord speaks of peace for his people.
FIRST READING Ezekiel 28:1-10
“You are but a man, and no god, though you consider yourself as wise as a god.”
A reading from the Book of the Prophet Ezekiel
The word of the LORD came to me: "Son of man,
say to the prince of Tyre, Thus says the Lord GOD: "Because your heart is
proud, and you have said, 'I am a god, I sit in the seat of the gods, in the
heart of the seas,' yet you are but a man, and no god, though you consider
yourself as wise as a god- you are indeed wiser than Daniel; no secret is
hidden from you; by your wisdom and your understanding you have gotten wealth
for yourself, and have gathered gold and silver into your treasuries; by your
great wisdom in trade you have increased your wealth, and your heart has become
proud in your wealth- therefore thus says the Lord GOD: "Because you
consider yourself as wise as a god, therefore, behold, I will bring strangers
upon you, the most terrible of the nations; and they shall draw their swords
against the beauty of your wisdom and defile your splendour. They shall thrust
you down into the Pit, and you shall die the death of the slain in the heart of
the seas. Will you still say, 'I am a god,' in the presence of those who slay
you, though you are but a man, and no god, in the hands of those who wound you?
You shall die the death of the uncircumcised by the hand of foreigners; for I
have spoken, says the Lord GOD."
The word of the Lord
RESPONSORIAL PSALM Dt 32:26-27ab.27cd-28.30.35cd-36ab
R. I kill and I make alive.
I would have said, I will scatter them afar, I will
make the remembrance of them cease from among men, had I not feared provocation
by the enemy, lest their adversaries should judge amiss.
R. I kill and I make alive.
Lest they should say, Our
hand is triumphant, the LORD has not wrought all this. For they are a nation
void of counsel, and there is no understanding in them.
R. I kill and I make alive.
How should one chase a thousand, and two put ten thousand to flight,
unless their Rock had sold them, and the LORD had given them up?
R. I kill and I make alive.
For the day of their calamity is at hand, and their
doom comes swiftly. For the LORD will vindicate his
people and have compassion on his servants.
R. I kill and I make alive.
R. Alleluia. Though Jesus Christ was rich, yet for our sake he became poor, so that by his poverty you might become rich. R. Alleluia.
GOSPEL Matthew 19:23-30
At that time: Jesus said to his disciples, "Truly, I say to you, it
will be hard for a rich man to enter the kingdom of heaven. Again I tell you,
it is easier for a camel to go through the eye of a needle than for a rich man
to enter the
The Gospel of the Lord


Daria makes machine learning an accessible reality for users of any skill level. The highly visualized interface helps novices use Daria with minimal programming knowledge, while industry experts enjoy vastly reduced hours of iterative work through Daria’s automated machine learning process.
Learn MoreDaria applies numerous machine learning training conditions to your data and constructs an environment where you can compare and analyze disparate results at a glance.
Learn MoreWe believe in the value of seeing hard work doing real good in the world. When your models are ready, deploy them with a single line of code to see them in action. No further complications.
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The inspection can be useful if you need to focus on modeling immutable data rather than extensible behavior. Automatic implementation of data-driven methods, such as equals and accessors, helps to get rid of boilerplate.
Note that not every class can be a record. Here are some of the restrictions:
To get a full list of the restrictions, refer to the Oracle documentation.
Example:
class Point {
private final double x;
private final double y;
Point(double x, double y) {
this.x = x;
this.y = y;
}
double getX() {
return x;
}
double getY() {
return y;
}
}
This record will be converted to:
record Point(int x, int y) {
}
This inspection only reports if the language level of the project or module is 16 or higher.
New in 2020.3


* If you leave the fields in a section empty, the section will not appear in your CV.
Basic Information
Academic Credentials
Key Skills
Career Objectives
Additional Activities
Project Work
Expereince


$5 for Students & Young Alumni
$10 for Faculty & Alumni
Formal Attire Requested
yale
new haven
SHARING MORE THAN A ZIP CODE
The Annual Hunger and Homelessness Auction was established in 1993 by Yale health professional students interested in raising community awareness of and alleviating the adversity caused by hunger and homelessness in the Greater New Haven area. Our mission is to educate the community on key social issues: poverty and food security to affordable housing, unemployment, health care equality, and the implications of substance abuse and mental illness.
Donate
The success of the auction depends on students, faculty, alumni and community members donating vacations, dinners, classes, concert tickets, and so much more. Donate what you can. Beach house or baked good, you make a difference!
For almost 50 years, Christian Community Action (CCA) has been combatting homelessness in New Haven’s Hill district by providing emergency housing, crisis intervention, and diversion assistance. The grant from H&H will enable CCA to expand their Neighborhood Assistance Program to provide diversion assistance to an additional 30 individuals in the coming year.
Liberty Community Services (LCS) strives to end homelessness in New Haven by helping people achieve and maintain permanent housing within the community. In particular, LCS provides assistance to people suffering from HIV/AIDS, mental illness, and addiction. This year’s H&H grant will support outreach efforts to identify and rapidly address the most pressing individuals needs of homeless people throughout New Haven.
Continuum of Care provides comprehensive community-based resident and support services for individuals with psychiatric and developmental disabilities. Through their Crisis Stabilization program, they divert individuals, many of whom are chronically homeless, from psychiatric emergency departments and in-patient facilities in order to provide a more direct path towards reintegration into the community. The grant from H&H will fund a 1-year pilot Peer Bridger program that will employ a formerly homeless individual to serve as an advocate and guide for currently homeless individuals to assist their recovery and journey back to community life.
For the past 22 years, the Community Health Care Van (CHCV) has provided much needed outreach, prevention, and medical care to the most vulnerable of New Haven’s residents. As a virtual “patient-centered medical home” within a 40-foot van, the CHCV’s mobile medical clinic (MMC) targets high risk neighborhoods impacted by poverty, drug use and unemployment to provide medical and psychiatric services, and diagnosis and treatment for infectious diseases and substance use disorders. This year’s grant from H&H will go towards medical supplies and education materials that are outside the scope of CHCV’s federal grant support.
Integrated Refugee & Immigrant Services (IRIS) resettles approximately 225 refugees, coming from numerous countries including Afghanistan, Iraq, Syria, Sudan, Ethiopia, and Democratic Republic of Congo, within the Greater New Haven area. IRIS meets the basic daily needs of all refugees they resettle and also promotes integration and self-sufficiency through educational and social services. With this year’s grant from H&H, IRIS will develop a Health and Wellness program for refugee women focusing on Psychoeducation, an orientation to available mental-health resources, a women’s empowerment group, an English class, and a cross-cultural mentorship program.
FISH of Greater New Haven delivers free groceries to food-insecure individuals who are homebound, many of whom are elderly, handicapped, or have recently undergone major operations. They are the only organization in the area doing this work. This year’s grant from H&H will enable FISH to serve 20% more individuals than in the previous year, helping to meet the tremendous demand for their services.


The smash-hit game! Play with millions of players around the world and try to become the longest of the day!
PlayPokémon battle simulator. Play Pokémon battles online! Play with randomly generated teams, or build your own! Fully animated!
PlayAn isometric shooter in which you can battle with your friends against an opposing team, or fight in a free-for-all with everyone. Power-up stations placed in the arena grant different weapons.
Play


Warning! The system is currently in read-only mode, and as a result a number of actions cannot be performed.
We are doing our best to fix the issue.


Popular Areas in avoid breathing smoggy and polluted air
Survey: Breathing Beijing's Smoggy Air Equal to Smoking 21 ...
Feb 7, 2013 . Survey: Breathing Beijing's Smoggy Air Equal to Smoking 21 Cigarettes . in several cities, breathing in the high levels of air pollution for one day was similar to smoking 21 cigarettes in Beijing, . So, stop smoking or relocate.
http://www.echinacities.com/news/Survey-Breathing-Beijings-Smoggy-Air-Equal-to-Smoking-21-Cigarettes
The Benefits and Risks of Exercise in Polluted Air | Wellness ...
Jul 5, 2012 . But is it better than the alternativeavoiding a workout altogether? . Breathing polluted air triggers inflammation and oxidative stress that increases your risk of asthma, . A ride on a smoggy day makes a bad situation worse.
http://www.outsideonline.com/fitness/wellness/Exhaust-Yourself-20120801.html
SmogWho Does It Hurt? - US Environmental Protection Agency
can do to avoid dangerous exposures. . is formed when pollutants emitted by . breathe it. On a hot, smoggy summer day, have you ever wondered: Is the air .
http://www.epa.gov/airnow/health/smog.pdf
Vocal Hygiene Practices | MyENTSpecialists
. and whole grain foods; Maintain body hydration (drink 7-9 glasses of water per day); Avoid dry, artificial interior climates; Avoid breathing smoggy, polluted air .
http://www.myentspecialist.com/vocal-hygiene-practices
Smog - Who does it hurt?
In fact, breathing smoggy air can be hazardous because smog contains ozone, . you should be concerned, and what you can do to avoid dangerous exposures. . ground level, ozone is formed when pollutants emitted by cars, power plants, .
http://airnow.gov/index.cfm?action=smog.page1


Guard Bayard:
You got the stone!
Waldstein was seen yesterday in the Varka Silenos stronghold and the Ketra Orc advance base. It seems like Waldstein was also looking for a stone. He may be headed towards the tablet!
Let's hurry! I'll stabilize the stone.
Watch


I am an Archivist/Librarian
A blog about stuff. And things. Sometimes both.
As a follow up to my presentation about Perceptual Hashing of A/V content (slides available here), I thought I would put up a quick post and some tools as a resource for anyone who is interested in experimenting more with this technology!
As my original work with perceptual hashing was conducted at CUNY-TV, the database and integrated scripts were built around CUNY-TV systems and workflows. While the original tools are all available within the microservices repository used at CUNY, I though it might lower the barrier to experimentation if I peeled out the tools related to hashing into their own resource.
Right now, this is in a little bit of a quick and dirty form, with some simplifications and changes to the CUNY scripts (more on that later), but it should serve as a means to quickly create a hash database to do some testing with.
I have created a repository at pugetsoundandvision that contains some basic scripts to create and configure a database to store perceptual hashes, generate and report hashes from source files and query the database for similar content. It can be found at:
https://github.com/pugetsoundandvision/perceptual
As I have been experimenting a bit with using hamming distance to compare hashes rather than the exact content match queries used in the CUNY tools, these experimental scripts differ from the CUNY tools in a couple ways.
bagofwords
components of the rough hash, only the first is being stored. This hash is broken up into 9 columns in the Database that represent 27 character subsets of the original binary bagofwords
.BIT_COUNT(hash1 ^ '${hashdec1}') + BIT_COUNT(hash2 ^ '${hashdec2}') ... <= 2"
The tools depend on having both MySQL and FFmpeg already installed, so if you don’t have those that is your first step! (Also, currently these tools only work in Mac or Linux systems).
The tools can either be downloaded as a ZIP from github or with the command git clone https://github.com/pugetsoundandvision/perceptual.git
Once downloaded, from within the perceptual
directory run the command ./createfingerprintdb.sh
. This will walk you through the process of creating a database, user and login profile for fingerprint storage/query. You will need to enter your MySQl root password a couple of times, and at the end it will output a command that you must run to create the login profile. You will run this command, followed by the password you selected for your user during database creation. Once this is done, the script should have automatically stored the database and login information in the FINGERPRINTDB_CONFIG.txt
file. If anything needs to be changed you can manually edit this file in a text editor.
Once the database has been created you can start populating it with perceptual hashes! To do this (again from within the perceptual
directory) run ./makefingerprint.sh INPUTFILE
. This can be run on any kind of video file, and the input doesn’t have to be in the same directory. The script does need the full absolute file path, so it works best if after typing ./makefingerprint.sh
you type a space and then drag your file into the terminal window. Don’t forget the space! This script will generate a full fingerprint (stored in a sub-directory in the same location as the input file) and report the bagofwords
information to the database.
Once you have some perceptual hashes stored in the database, you can query against it using the searchfingerprint.sh
script. This script allows you set an in point and out point for fingerprint comparison so shorter subsections of videos (such as individual scenes) can be quickly compared. An example of this would be ./searchfingerprint.sh -i 30 -o 60 INPUTFILE
. This command would create and compare fingerprints for content starting at 30 seconds and ending at 60 seconds in the input file. To run a comparison against a whole input file you would use ./searchfingerprint INPUTFILE
.
If matching content is discovered, the output will look something like
where the first column is the mediaid (yes I am still using Temple of the Dog as my test file), the second column is the in frame of the matching segment, the third is the out frame of the matching segment, and the fourth and fifth are the first two elements of the matching hash.
This repository was developed as a starting point for some research/experimentation with perceptual hashes. I am planning on modifying it to store more hash information and to be faster (probably ultimately rewriting the scripts in a different language such as Ruby). I hope this is helpful for anyone who wants to give hashing a try - let me know any questions, comments or successes you may have!


Centre
Standard centred element with auto margins
Bob
Centred with added text-align: center for text
Lorem ipsum dolor sit amet
Centred element with centred block-level child element
Press me
@@include('./head.html')
@@include('./global_header.html')Bob
Lorem ipsum dolor sit amet


Fraction Calculator v3.0
Home
Simplify
Simplify a fraction
Simplify completely before turning into mixed number
Simplify
Clear
Simplify Again
Mixed Number


Getting Started¶
Required software¶
Linux/Unix and Developer Tools
Lotus needs to compile a small fortran script file at the start of every simulation. This is way too difficult to do with Windows machines. (cmake
is an option, but we don’t recommend it.)
Ubuntu comes preloaded with git
and make
.
OSX users should open the terminal
app and type:
$ git
At the prompt, you can download the developer tools.
Dropbox
Install dropbox and join the dropbox folder ‘repos’. These instruction assume the folder is located at ~/Dropbox/repos/
Programming languages and libraries
- gfortran (v4.8+): The code is written in fortran, so you’ll need a compiler. Check your version using::
- $ gfortran –version
MPICH : To run in parallel on a multi-core machine, you’ll need to install this library.
python : We recommend doing all of the data-analysis and visualization in python. This can also be used to run a series of simulations and to update these documents.
R-project : An alternative data-analysis and visualization language. Some usefull libraries to install:
$ sudo R
> install.packages("ggplot2")
> install.packages("dplyr")
Additional Software
convert (v6.9+): Convert is a cross platform library to create and manipulate images. It is required for the code to generate images during run-time.
paraview : The output binary file can be read and rendered using paraview.
atom : This is a great text editor with lots of add-ons for efficient and easy coding such as the language-fortran package.
Setting up¶
Add Profile
A profile file holds a list of shortcuts and adds things to your working PATH
.
If you’re on Ubuntu:
$ cp ~/Dropbox/repos/profile_ubuntu.txt ~/.profile
$ atom ~/.bashrc
which will open the bach file. Add the lines:
# read user scripts
source ~/.profile
If you’re on OSX:
$ cp ~/Dropbox/repos/profile_osx.txt ~/.profile
In either case, you can now open a new terminal (which will automatically invoke the profile) or source
it in the current terminal:
$ source ~/.profile
Clone Libraries
Now you’re ready to get Lotus. Make a Workspace folder and go into it:
$ mkdir -p ~/Workspace/
$ cd ~/Workspace
Clone the solver repositories:
$ git clone -o dropbox ~/Dropbox/repos/solver
$ cd solver
$ git clone -o dropbox ~/Dropbox/repos/oop
Note than when you clone the solver, there will be a separate README file in that folder. This file applies to an old version of the code. You do not need to follow those instructions for Lotus installation.
Build Libraries
This step is optional since running the Lotus will build the libraries automatically:
$ cd ~/Workspace/solver/geom_lib
$ make
$ cd ../oop
$ make
There should be no errors though possibily a few warnings.


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Home
Welcome to my notebook (and sometimes blog)!I try to keep this page up-to-date with the various projects I am undertaking. Projects are usually computer related in some way, but every now and then I require some down time and switch gears to something like bone carving.
Recent Notes
-
{{ range lop .Posts 0 5 }}
-
{{ .Title }} - {{ .Date | shortDate}}
{{ .Description }}
{{ end }}
qbit/snap
snap is a utility I wrote to make it a bit easier to jump to new snapshot releases of OpenBSD.
snap can be verified with signify(1) by using the below public key:
Pub key
untrusted comment: github.com/qbit/snap public key
RWQVGN6sUjQQA5uYpANGLLKQMAERZ43otLePFSVqNFGGtf/qBez7G1WU
To verify snap:
signify -C -p /etc/signify/snap.pub -x SHA256.sig snap
The above assumes that the public key listed above has been put in /etc/signify/snap.pub.
Old pub keys
untrusted comment: github.com/qbit/snap public key
RWTKOAnI3kqGqY/1ungBemfzkDj4ImXuybf4sDZcCrNJywffIRDkK1qF
untrusted comment: github.com/qbit/snap public key
RWQkqrbMjoywaLwJQf45TjtCLgtFPSEO7v/TBf01WRZjvl8NSy6rJ6Fe


Introduction
In this YouTube video Kie Codes demonstrated an example of how to generate a melody using a genetic algorithm.
The process involves creating a population of genomes that represent a short melody, and then using an evolutionary algorithm to select the best melodies based on user-provided ratings (on a scale of 0 to 5). The selected melodies are then mated and mutated to generate a new population. The full code for this example can be found on GitHub.
One of the most time-consuming aspects of Kie’s example is the requirement for the user to rate each generated melody by listening to the result. To eliminate this tedious task, we will add an evaluation network that can rate the generated music.
This network will be trained on a subset of labeled melodies to predict the rating of an unseen piece of music. Once the evaluation network is fully trained, the evolutionary algorithm can quickly obtain feedback on the quality of the generated music, without the need for manual rating.
Since the approach with an evaluation network still requires a large amount of labeled data for pre-training, we will implement an active learning mechanism. This means that the network can be pre-trained with a small amount of data, then as it encounters new data, it tracks how certain the model is in its predictions. For the most uncertain melodies, a label is requested from the user, and the model is re-trained based on the new labeled data. This allows for more efficient querying of the user, only when deemed necessary.
By implementing all the components independently (evolutionary algorithm, validation network, and active learner), the waiting time for user input is minimized. The evolutionary algorithm continues to improve while the active learner collects labels and retrains the evaluation network.
As depicted, we will also include a user interface component to handle the communication for starting and stopping the process, as well as collecting new labels from the user.
This example illustrates how swergio simplifies the process of enabling independent live training across independent components, as well as incorporating user feedback into the loop.
In the following sections, we will examine each component in more detail.


|
||||||||||
| PREV CLASS NEXT CLASS | FRAMES NO FRAMES | |||||||||
| SUMMARY: NESTED | FIELD | CONSTR | METHOD | DETAIL: FIELD | CONSTR | METHOD |
public interface VmApi
Provides access to VM functionality in vCloud
| Method Summary | |
|---|---|
Task |
deployAndPowerOnVm(URI href)
like #deploy(URI) , except deploy transitions to power on state |
Task |
deployVm(URI href)
To deploy a vApp, the client makes a request to its action/deploy URL. |
InputStream |
getScreenThumbnailForVm(URI vm)
Get a Screen Thumbnail for a Virtual Machine |
Vm |
getVm(URI href)
|
Task |
powerOffVm(URI href)
A powerOff request to a vApp URL powers off all of the virtual machines in the vApp, as specified in its StartupSection field. |
Task |
powerOnVm(URI href)
A powerOn request to a vApp URL powers on all of the virtual machines in the vApp, as specified in the vApp’s StartupSection field. |
void |
rebootVm(URI href)
A reboot request to a vApp URL reboots all of the virtual machines in the vApp, as specified in its StartupSection field. |
Task |
resetVm(URI href)
A reset request to a vApp URL resets all of the virtual machines in the vApp, as specified in its StartupSection field. |
void |
shutdownVm(URI href)
A shutdown request to a vApp URL shuts down all of the virtual machines in the vApp, as specified in its StartupSection field. |
Task |
suspendVm(URI href)
A suspend request to a vApp URL suspends all of the virtual machines in the vApp, as specified in its StartupSection field. |
Task |
undeployAndSaveStateOfVm(URI href)
like #undeploy(URI) , where the undeployed virtual machines are suspended and their
suspend state saved |
Task |
undeployVm(URI href)
Undeploying a vApp powers off or suspends any running virtual machines it contains, then frees the resources reserved for the vApp and sets the vApp’s deploy attribute to a value of false to indicate that it is not deployed. |
Task |
updateCPUCountOfVm(int cpuCount,
URI href)
update the cpuCount of an existing VM |
Task |
updateGuestCustomizationOfVm(GuestCustomizationSection guestCustomizationSection,
URI href)
Modify the Guest Customization Section of a Virtual Machine |
Task |
updateMemoryMBOfVm(int memoryInMB,
URI href)
update the memoryInMB of an existing VM |
Task |
updateNetworkConnectionOfVm(NetworkConnectionSection networkConnectionSection,
URI href)
Modify the Network Connection Section of a Virtual Machine |
| Method Detail |
|---|
Vm getVm(URI href)
Task deployVm(URI href)
Task deployAndPowerOnVm(URI href)
#deploy(URI)
, except deploy transitions to power on state
Task undeployVm(URI href)
#undeployAndSaveStateOf
Task undeployAndSaveStateOfVm(URI href)
#undeploy(URI)
, where the undeployed virtual machines are suspended and their
suspend state saved
Task powerOnVm(URI href)
Task powerOffVm(URI href)
void shutdownVm(URI href)
Task resetVm(URI href)
void rebootVm(URI href)
Task suspendVm(URI href)
InputStream getScreenThumbnailForVm(URI vm)
href
- to snapshotTask updateGuestCustomizationOfVm(GuestCustomizationSection guestCustomizationSection, URI href)
href
- uri to modifyupdated
- guestCustomizationSection
Task updateNetworkConnectionOfVm(NetworkConnectionSection networkConnectionSection, URI href)
href
- uri to modifyupdated
- networkConnectionSection
Task updateCPUCountOfVm(int cpuCount, URI href)
href
- to updatecpuCount
- count to change the primary cpu toTask updateMemoryMBOfVm(int memoryInMB, URI href)
href
- to updatememoryInMB
- memory in MB to assign to the VM
|
||||||||||
| PREV CLASS NEXT CLASS | FRAMES NO FRAMES | |||||||||
| SUMMARY: NESTED | FIELD | CONSTR | METHOD | DETAIL: FIELD | CONSTR | METHOD |


I am a passionate, results-driven student with a love for design, business, and computer science. I'm currently a junior studying computer science and economics at New York University.


Greetings $USERNAME$,
You have registered for an Eagleslist account using the email $EMAIL$.
Please click on the following link or copy and paste it into your browser to complete the email verification process: https://www.google.com
You may begin creating posts and replying to other listings once your verification is complete.


{% extends 'base.html' %} {% block content %}
EventTypes define categories or types of events, like "Music Act" or "Workshop" or "Talk". They are not camp specific, so they are not editable here.
{% if not event_type_list %}No EventTypes found. Is this the twillight zone?
{% else %}| Name | Sessions | Slots | Events | Actions |
|---|---|---|---|---|
| {{ type.icon_html }} {{ type.name }} | {{ type.event_sessions_count }} | {{ type.event_slots_count }} | {{ type.event_count }} |


Abstract
Dematerialization in HCI community refers to a process in which contents become disengaged from fixed carriers. In other words, contents no longer require physical medium and can rather flow freely through networks and devices [ Physical Interaction in a Dematerialized World ]. The best exemplar of this phenomenon is CDs being replaced by digital files. In this project we focus on dematerialization of physical light sources. Studies on designing interaction methods for dematerialization of light is not new. However, previous studies on light dematerialization either points to emotional aspect of candle usage or introduce usage-specific interactions on screen. In contrast, the primary goal of this project is in enhancing user experience of candle lights using physical interaction design. Th electric candle light introduced in this project is a physical artifact in the form of a candle that can be lit up using finger-swipe motion. We use candle melting metaphor to implement the candle height lowering to the base level as time ticks by for following reason: it helps users to visualize energy consumption.
System Design
Technical Implementation
* Hardware
Descending candle frame is implemented with a linear actuator with –driver and configured appropriately to be used with Arduino Nano. Two limit switches have been placed on maximum and minimum location the actuator can reach since the motor can only be driven by a positive or a negative speed. As the motor requires 12V, an external power supply is used. For candle flames, two two-legged LEDs are used. A microphone module is positioned near the 3D-printed flame for receiving blowing input. A pressure sensor along with a button switch is fixed on the bottom part of the candle frame body.
* Software
The software program to control all digital and analog inputs as well as output components including button switch, limit switches, pressure sensor, LEDs, microphone, and linear actuator are all coded and managed in Arduino IDE. The code used in this project can be found here.


ASEAN defense
ASEAN defense ministers and dialogue nations defense ministers from left, India's Rajnath Singh, Indonesia's Prabowo Subianto, Japan's Taro Kono, Lao's Gen. Chansamon Chanyalath, Malaysia's Mohamad Sabu, Thailand's deputy prime minister Prawit Wongsuwan, Vietnam's Ngo Xuan Lich, Myanmar's Sein Win, and New Zealand's Ron Mark pose for a group photo in Bangkok, Thailand, on Monday.
© AP


The Fcron package contains a periodical command scheduler which aims at replacing Vixie Cron.
This package is known to build and work properly using an LFS-9.1 platform.
Download (HTTP): http://fcron.free.fr/archives/fcron-3.2.1.src.tar.gz
Download MD5 sum: bd4996e941a40327d11efc5e3fd1f839
Download size: 587 KB
Estimated disk space required: 5.1 MB
Estimated build time: 0.1 SBU
An MTA, text editor (default is vi from the Vim-8.2.0190 package), Linux-PAM-1.3.1, and DocBook-utils-0.6.14
User Notes: http://wiki.linuxfromscratch.org/blfs/wiki/fcron
Fcron uses the cron facility of syslog to log all messages. Since
LFS does not set up this facility in /etc/syslog.conf
, it needs to be done prior to
installing Fcron. This command
will append the necessary line to the current /etc/syslog.conf
(perform as the root
user):
cat >> /etc/syslog.conf << "EOF"
# Begin fcron addition to /etc/syslog.conf
cron.* -/var/log/cron.log
# End fcron addition
EOF
The configuration file has been modified, so reloading the
sysklogd daemon will
activate the changes (again as the root
user).
/etc/rc.d/init.d/sysklogd reload
For security reasons, an unprivileged user and group for
Fcron should be created (perform
as the root
user):
groupadd -g 22 fcron && useradd -d /dev/null -c "Fcron User" -g fcron -s /bin/false -u 22 fcron
Install Fcron by running the following commands:
./configure --prefix=/usr \ --sysconfdir=/etc \ --localstatedir=/var \ --without-sendmail \ --with-boot-install=no \ --with-systemdsystemunitdir=no && make
This package does not come with a test suite.
Now, as the root
user:
make install
DESTDIR install must be done as root
user.
--without-sendmail
: By
default, Fcron will attempt to use
the sendmail command
from an MTA package to
email you the results of the fcron script. This switch is used
to disable default email notification. Omit the switch to enable
the default. Alternatively, you can use the --with-sendmail=
to use a different mailer command.
</path/to/MTA command>
--with-boot-install=no
:
This prevents installation of the bootscript included with the
package.
--with-systemdsystemunitdir=no
: This
prevents building the systemd
units, which are not needed for a SYS
V system.
--with-editor=
:
This switch allows you to set the default text editor.
</path/to/editor>
--with-dsssl-dir=
:
May be used if you have DocBook-utils-0.6.14 installed.
Currently, the dsssl stylesheets are located at </path/to/dsssl-stylesheets>
/usr/share/sgml/docbook/dsssl-stylesheets-1.79
.
There are no required changes in any of the config files.
Configuration information can be found in the man page for
fcron.conf
.
fcron scripts are written using fcrontab. Refer to the fcrontab man page for proper parameters to address your situation.
If Linux-PAM is installed, two PAM
configuration files are installed in etc/pam.d
. Alternatively if etc/pam.d
is not used, the installation will
append two configuration sections to the existing /etc/pam.conf
file. You should ensure the files
match your preferences. Modify them as required to suit your
needs.
If you would like to setup a periodic hierarchy for the root
user, first issue the following commands (as the root
user to create the /usr/bin/run-parts
script:
cat > /usr/bin/run-parts << "EOF" &&
#!/bin/sh
# run-parts: Runs all the scripts found in a directory.
# from Slackware, by Patrick J. Volkerding with ideas borrowed
# from the Red Hat and Debian versions of this utility.
# keep going when something fails
set +e
if [ $# -lt 1 ]; then
echo "Usage: run-parts <directory>"
exit 1
fi
if [ ! -d $1 ]; then
echo "Not a directory: $1"
echo "Usage: run-parts <directory>"
exit 1
fi
# There are several types of files that we would like to
# ignore automatically, as they are likely to be backups
# of other scripts:
IGNORE_SUFFIXES="~ ^ , .bak .new .rpmsave .rpmorig .rpmnew .swp"
# Main loop:
for SCRIPT in $1/* ; do
# If this is not a regular file, skip it:
if [ ! -f $SCRIPT ]; then
continue
fi
# Determine if this file should be skipped by suffix:
SKIP=false
for SUFFIX in $IGNORE_SUFFIXES ; do
if [ ! "$(basename $SCRIPT $SUFFIX)" = "$(basename $SCRIPT)" ]; then
SKIP=true
break
fi
done
if [ "$SKIP" = "true" ]; then
continue
fi
# If we've made it this far, then run the script if it's executable:
if [ -x $SCRIPT ]; then
$SCRIPT || echo "$SCRIPT failed."
fi
done
exit 0
EOF
chmod -v 755 /usr/bin/run-parts
Next, create the directory layout for the periodic jobs (again as
the root
user):
install -vdm754 /etc/cron.{hourly,daily,weekly,monthly}
Finally, add the run-parts to the system
fcrontab (while still the root
user):
cat > /var/spool/fcron/systab.orig << "EOF"
&bootrun 01 * * * * root run-parts /etc/cron.hourly
&bootrun 02 4 * * * root run-parts /etc/cron.daily
&bootrun 22 4 * * 0 root run-parts /etc/cron.weekly
&bootrun 42 4 1 * * root run-parts /etc/cron.monthly
EOF
Install the /etc/rc.d/init.d/fcron
init script from the blfs-bootscripts-20191204 package.
make install-fcron
Finally, again as the root
user,
start fcron and generate the /var/spool/fcron/systab
file:
/etc/rc.d/init.d/fcron start && fcrontab -z -u systab
Last updated on 2020-03-19 05:00:16 -0500


Preview: Lightning hit the road to take on defending-champion Blues
by APTV: NCBSN
TIME: 8 p.m.
STREAM IT LIVE ON FOX SPORTS GO
Tampa Bay Lightning (9-6-2, sixth in the Atlantic Division) vs. St. Louis Blues (12-4-5, first in the Central Division)
BOTTOM LINE
St. Louis aims to end its three-game slide when the Blues play Tampa Bay.
The Blues are 5-2-3 at home. St. Louis has given up 12 power-play goals, killing 80.6% of opponent chances.
The Lightning are 5-4-1 in road games. Tampa Bay ranks second in the NHL averaging 3.7 goals per game, led by Steven Stamkos with seven.
The matchup Tuesday is the first meeting of the season for the two teams.
TOP PERFORMERS
Brayden Schenn leads the Blues with 11 goals and has recorded 18 points. Ryan O’Reilly has scored four goals over the last 10 games for St. Louis.
Stamkos leads the Lightning with seven goals and has 20 points. Victor Hedman has collected four goals and six assists over the last 10 games for Tampa Bay.
LAST 10 GAMES
Lightning: 5-4-1, averaging 3.7 goals, 6.8 assists, 4.7 penalties and 13.3 penalty minutes while giving up 3.5 goals per game with a .892 save percentage.
Blues: 7-1-2, averaging three goals, 5.7 assists, 3.1 penalties and 6.2 penalty minutes while giving up 2.4 goals per game with a .921 save percentage.
Blues Injuries: None listed.
Lightning Injuries: None listed.


class UserManager
Class UserManager manages the creating of new users, updating existing users and removing users.
Properties
| array | $errors | Errors are kept in an array and can be used later if validation fails and we want to know why |
| string | $messages | Messages which we can store why validation failed |
Methods
|
__construct(DvsUser $DvsUser, Framework $Framework)
Construct a new user manager |
||
| array |
createRules()
Create rules for a new user |
|
| DvsUser |
createUser(array $input)
Create a new user |
|
| array |
updateRules(integer $id, array $input)
These are update rules for a user |
|
| DvsUser |
updateUser(integer $id, array $input)
Update a new user |
|
| boolean |
destroyUser(integer $id)
Delete a user |
|
| boolean |
activate(DvsUser $user)
Activate instance of DvsUser |
|
| string |
generateActivateCode(DvsUser $user, integer $length = 42)
Generate a random "activate_code" string |
Details
at line 62
public
__construct(DvsUser $DvsUser, Framework $Framework)
Construct a new user manager
at line 74
public array
createRules()
Create rules for a new user
at line 90
public DvsUser
createUser(array $input)
Create a new user
at line 119
public array
updateRules(integer $id, array $input)
These are update rules for a user
at line 144
public DvsUser
updateUser(integer $id, array $input)
Update a new user
at line 176
public boolean
destroyUser(integer $id)
Delete a user
at line 188
public boolean
activate(DvsUser $user)
Activate instance of DvsUser
at line 202
public string
generateActivateCode(DvsUser $user, integer $length = 42)
Generate a random "activate_code" string


Transfer Update: Mbappe
by Kurt BuckerfieldWith Spanish giants Real Madrid reportedly preparing a move for Paris Saint-Germain superstar Kylian Mbappe, here is the latest on the Frenchman's future.
10 Players Who Left Real Madrid Because Of Ronaldo
Reports in Spain and France in recent weeks have suggested that Los Blancos are readying a big-money move for the 20-year-old, but there now seems to be a new development.
According to ESPN, to counter the threat of the 13-time UEFA Champions League winners, PSG have offered the striker a new contract in France.
The Ligue 1 giants are believed to have no intentions of letting the forward leave next season, which is when Real were said to be hoping to lure him to Spain.
Choose the left midfielder for SA's Real Madrid Dream Team & win a replica shirt!
It has also been claimed that Mbappe has given the French champions his word that he will not look to leave ahead of the 2020/21 season, although it remains to be seen whether or not he accepts the club's new deal for him.
The new contract would see the forward earn nearly as much as Neymar, whose future in France is still unclear amid constant speculation that he could return to FC Barcelona.
The Only Player Messi Asked To Swap Shirts With
Since Mbappe's arrival at PSG in 2017, he has scored 69 goals and assisted a further 36 strikes in 98 matches for the club.


I am a junior currently attending the University of Central Florida. I am majoring in computer science and plan to graduate in the fall of 2019.
Worked as a cashier as well as performed duties as a cart attendant. Developed positive customer relationships through friendly greetings and excellent service. Organized racks and shelves to maintain the visual appeal of the store.
Maintained the golf course in playing conditions by using various machinery. Followed routine and preventative maintenance checklists.
Assisted with the installation and repair of garage doors and garage door equipment. This required the use of power tools and specialized equipment.
Current: GPA: 3.23
GPA: 3.42
GPA: 4.20
Other than programming, I take a great interest in playing music. I'm a self taught pianist. I enjoy music ranging from classical all the way through rock such as The Doors.
I also like to travel and keep up with the latest technological news.


CHAPTER 192
SHOOTING PRESERVES AND GAME BIRD FARMING
REPEALED. L 1985, c 174, §6.
Cross References
For present provisions, see chapter 183D.


Additional resources.
Here you can find additional resources to specific programming languages or general information about programming languages. In addition, this also acts as a collection of my sources as I consulted most of these websites while researching.
Attributes
Type systems
Explanation of weak and strong typing Explanation of static and dynamic typing
Compilating and interpreting
Additional information about compilation About the women who invented the compiler
Generations of programming languages
High level and low level
Languages
Rust
The official book to learn Rust Website explaining features of Rust More features of Rust explained!
JavaScript
Java
C
Very detailed description of C
Brainf*** and Assembly
Hello World in Brainfuck An explanation of Brainfuck An introdction to Assembly
Scratch
Scratch's website where you can create programs Information about Scratch


| DOSE: |
2.5 |
oral |
GHB |
(liquid) |
Couple of fraternity brothers of mine, had done GHB several times recent to this incident, and were quite experienced with other hallucinogens, and had received it from the same person and in the same type of bottle. This was a small plastic bottle with a spring water bottle-type top. They had been told to do 2 'shots' of one capful per shot, to equal one dose. On this particular occasion, the batch was supposedly strengthened by 3 to 4X. This means that one dose is instead a half capful. Since they had previously figured out their tolerance of one dose to be adequately tolerable, one of the two of them decided he could handle a double dose. However, he had not been informed by his roommate whom had been the one buying it, that this batch was more potent than the last 3 or 4 batches that they had bought. So, he took 4 capfuls. Aforementioned, this equals out to about 12-16 doses, depending on actual potency (who can tell).
Needless to say, this was entirely too much. When I heard the toilet repeatedly flushing, I knew someone was getting sick. He described the experience later to me (was in NO condition to do so then) when he was puking his brains out as a full-on hallucinatory experience. His stomach hurt from the clenching, but otherwise it was not an inherently bad experience. To start. This was about 45 mins after he ingested the dose. Slowly and slowly, he began to lose more and more function. By T+1:30, he was acting the same as people coming home from the bar on their 21st birthday ---- barely audible speech due to slurring, poor motor coordination, and nodding head. He was also back in the bathroom dry-heaving. At T+2, his breathing began to become extremely heavy, and erratic. He told me later that he was still hallucinating at this point, but it was more of an internal type of 'dream' hallucination as is common with the closed eye visuals of ecstacy or mushrooms when mixed with nitrous oxide.
He didn't notice, but when he would not off his breathing would go from short to heavy, to short to long, etc. Also, I noticed his muscles going into involuntary spasms usually directed along the side he was not currently rolled onto. I will tell you, I have witnessed many different 'bad' reactions to drugs, including bad trips, alcohol poisoning, withdrawal from morphine (me personally on that one, while in the hospital), and heroin.
 Blah blah blah it's fun when you do the right amount, fine. What about when you don't? How are you to tell? Until a standard system for both synthesis and testing is availible, I think that anyone who would try something that they cannot even distinguish from water by looking is out of their mind [Erowid reminder...Always color your GHB with blue food coloring].  It's just that simple. All you have to ask yourself is, do you trust the person you're buying this from, that they could make it in their bathtub and DEFINITELY know exactly what they're doing? GHB as it is TODAY, is too dangerous to be trifled with. It's not worth the risk if their's no way to know what your getting.
Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid.


*** User 2017-05-05 19:57:45.495 ***
19:57:45.495 [info] Disabling blocking sync...
*** User 2017-05-05 19:57:45.500 ***
19:57:45.500 [info] Configured peer_service_manager partisan_default_peer_service_manager on node 'node-1@MacBook-Pro-de-Anne-France'
*** User 2017-05-05 19:57:47.010 ***
19:57:47.010 [info] Enabling membership...
*** User 2017-05-05 19:57:47.012 ***
19:57:47.011 [info] Disabling blocking sync...
*** User 2017-05-05 19:57:47.016 ***
19:57:47.016 [info] Configured peer_service_manager partisan_default_peer_service_manager on node 'node-2@MacBook-Pro-de-Anne-France'
*** User 2017-05-05 19:57:48.538 ***
19:57:48.538 [info] Enabling membership...
*** User 2017-05-05 19:57:48.539 ***
19:57:48.539 [info] Disabling blocking sync...
*** User 2017-05-05 19:57:48.544 ***
19:57:48.544 [info] Configured peer_service_manager partisan_default_peer_service_manager on node 'node-3@MacBook-Pro-de-Anne-France'
*** User 2017-05-05 19:57:48.809 ***
Joining node: 'node-3@MacBook-Pro-de-Anne-France' to 'runner@MacBook-Pro-de-Anne-France' at port 55884
*** User 2017-05-05 19:57:48.809 ***
Joining issued: 'node-3@MacBook-Pro-de-Anne-France' to 'runner@MacBook-Pro-de-Anne-France' at port 55884
*** User 2017-05-05 19:57:48.810 ***
Joining node: 'node-2@MacBook-Pro-de-Anne-France' to 'runner@MacBook-Pro-de-Anne-France' at port 55869
*** User 2017-05-05 19:57:48.810 ***
Joining issued: 'node-2@MacBook-Pro-de-Anne-France' to 'runner@MacBook-Pro-de-Anne-France' at port 55869
*** User 2017-05-05 19:57:48.811 ***
Joining node: 'node-1@MacBook-Pro-de-Anne-France' to 'runner@MacBook-Pro-de-Anne-France' at port 55856
*** User 2017-05-05 19:57:48.811 ***
Joining issued: 'node-1@MacBook-Pro-de-Anne-France' to 'runner@MacBook-Pro-de-Anne-France' at port 55856
*** User 2017-05-05 19:57:48.872 ***
Waiting for join to complete with manager: partisan_default_peer_service_manager
*** User 2017-05-05 19:57:48.873 ***
Finished.
*** CT 2017-05-05 19:57:48.873 *** COVER INFO
Adding nodes to cover test: ['runner@MacBook-Pro-de-Anne-France']
*** CT 2017-05-05 19:57:48.884 *** COVER INFO
Successfully added nodes to cover test: []
*** User 2017-05-05 19:57:56.913 ***
Case finished: filter_test
*** User 2017-05-05 19:58:03.959 ***
19:58:03.959 [info] Application lasp exited with reason: stopped
*** User 2017-05-05 19:58:03.959 ***
19:58:03.959 [info] Application partisan exited with reason: stopped
=== Ended at 2017-05-05 19:58:03
=== successfully completed test case
=== Returned value: ok
Test run history
| Top level test index


If this is the first time running the program, make sure your computer is connected to the internet.


{{emailError}}
{{phoneError}}
At least 8 characters. 1 letter. 1 number
An error occured. Contact us at<EMAIL_ADDRESS>for help.


India-Pakistan Davis Cup clash to be held in Kazakhstan
by FRENCH PRESS AGENCY - AFPIndia and Pakistan's Davis Cup tie originally scheduled to take place in Islamabad will now be played in Kazakhstan's capital Nur-Sultan, the International Tennis Federation (ITF) announced on Wednesday.
The Asia/Oceania Group I match had initially been planned for September, but was pushed back to Nov. 29-30 after safety fears were raised by India amid tensions between the neighboring nations over Kashmir.
The move comes after the ITF's Davis Cup Committee rejected on Tuesday the Pakistan Tennis Federation's appeal against the decision to move the match from Islamabad.
"The Davis Cup Committee has voted in favour of the tie being hosted by the ITF on neutral ground at the National Tennis Centre in Nur-Sultan (previously Astana) on Nov. 29-30," The ITF said in a statement.
The match was moved from Islamabad on Nov. 4 following a review by the ITF's independent security advisors.
Kashmir has been divided between the India and Pakistan since the end of British colonial rule in 1947. Both claim the territory in full and have fought two wars over it.
An anti-India insurgency in the part of Kashmir that India administers - it has several hundred thousand troops there - has left tens of thousands of people dead over the past 30 years, most of them civilians.
In August, New Delhi revoked the special status of the part of the region that it administers.
An Indian tennis team last played a Davis Cup tie in Pakistan in 1964, when they beat the hosts 4-0. Pakistan lost 3-2 when they played in Mumbai in 2006.


{% include 'top.html' %}
This is a direcory and search engine of the podcasts being produced in Cascadia.
We would like this list to be as complete as possible. Any podcast in the region can be added.
We have {{number_of_podcasts}} active podcasts in our database.
Add Your Podcast!
Interviews with the podcasters of the PNW. We talk about to podcasters about their show. Why they make it, how they make it, and a little about podcasting in general. Email Jason Rigden to become a guest on the show!
Subscribe on Apple Podcasts, Spotify,or good old fashion RSS.


Quix's bump
i love nudes
xmark_circle_fill
i love nudes
-
Plague IncGames
GET
Login
-
Username
-
Password
Some text about login information.
Click "Sign In" to close Login Screen
Click "Sign In" to close Login Screen


Panel with Toolbar
A layout panel may be created with a toolbar. It uses w2toolbar object, therefore, you can use anything w2toolbar support. There is no need to define a name of the toolbar, because it will be overwritten with layout.name + '_toolbar'. It will also add toolbar.owner attribute that is a reference to the layout.
You can dynamically load content into the main panel; this is done so you can observe the overflow behavior of the panel (scrollbars).


Postal Experiments
“The USPS appears to have some collective sense of humor, and might in fact here be displaying the rudiments of organic bureaucratic intelligence.”
“The USPS appears to have some collective sense of humor, and might in fact here be displaying the rudiments of organic bureaucratic intelligence.”


RBI Baseball returns in 2020 with promises of a makeover
Follow Polygon online:
by Owen S. GoodMajor League Baseball’s official game, and the only MLB game for Xbox One, returns next year with RBI Baseball 20, with developers promising a makeover in its hitting and pitching systems, plus an update to ball physics and fielder AI.
A launch date was not given. Typically the game launches in March. RBI Baseball 20 will be released on Nintendo Switch, PlayStation 4, Xbox One, and Android and iOS mobile devices.
Christian Yelich of the Milwaukee Brewers, the 2018 National League MVP, is the game’s cover star, although the $29.99 game is more frequently bought online. MLB used today’s announcement to tout the Brewers’ new uniforms, which celebrates the franchise’s 50th anniversary in Milwaukee with a classic design and the ball-and-glove MB logo made famous by the 1982 American League champions.
MLB resurrected RBI Baseball in 2014 with RBI Baseball 14, as a modern console revival of the arcade-style gameplay remembered from the Nintendo Entertainment System classic. The game is developed by the MLB Games and VR Team, a unit of MLB Advanced Media, making Major League Baseball the only league that produces its own video game.


WITNESS LIST Human Services Committee (Subcommittee on Welfare Reform) April 15, 1999-9:00A Welfare related issues On: Anderson, Anita (Texas Department of Human Services), Austin Bresette, Patrick (Center for Public Policy Priorities), Austin Coufal, David (Texas Workforce Commission), Austin Garvin, John (Texas Department of Housing and Community Affairs), Austin Martinez, Libby (Senator Eliot Shapleigh's Office), Austin Temple, Larry (Texas Workforce Commission), Austin Registering, but not testifying: On: Anderson, Vicki (Texas Council on Workforce and Economic Competitiveness), Austin Denton, Judy L. (Texas Department of Human Services), Austin Funk, Richard (Texas Council on Workforce and Economic Competitiveness), Austin


This discussion group explores the philosophy of mental disorder from the perspective of patient experiences and with the aim of learning practical lessons for how we can better understand what it is like to have a mental disorder and how to treat it well.
This year our main focus will be the Mental Capacity Act (2005) and its implications. Last year, we met in person at King’s College London to read papers on phenomenology. Following Covid-19 and university strikes we moved our last meeting to Zoom. We will start back up again in September 2020, either in person or on Zoom, depending on the circumstances. Our tradition of free Reese’s peanut butter cups will be difficult to continue over Zoom but we will find a way if need be.
Find us on Facebook for event and reading list updates. We are open to topic suggestions and welcome attendees to present on topics they are interested in.
2nd meeting: 6-7pm on Monday December 7th, 2020 (Zoom).
Topic: The Ability to Value.
How, if at all, do authenticity, emotion, motivation, and value fit into an account of decision-making capacity? Scott Kim’s paper argues for an integrated model that adds the ability to value to the familiar list of requirements for decision-making capacity. Jennifer Hawkins’s commentary provides a criticism and amendment to Kim’s account.
RSVP: by Facebook or by email.
1st meeting: 6-7pm on Monday October 26th, 2020 (Zoom).
Topic: Introducing the Mental Capacity Act.
RSVP: by Facebook or by email.
8th meeting: 6-7pm Wednesday April 1, 2020 (Zoom).
7th meeting: 6-7pm Monday February 17, 2020 (KCL Strand PB605).
6th meeting: 6-7pm Monday February 10, 2020 (KCL Strand PB605).
5th meeting: 6-7pm Monday December 4, 2019 (KCL Strand PB605).
4th meeting: 6-7pm Monday November 18, 2019 (KCL Strand PB605).
3rd meeting: 6-7pm Monday November 4, 2019 (KCL Strand PB605).
2nd meeting: 6-7pm Monday October 21, 2019 (Thomas Guy Club).
1st meeting: 6-7pm Monday October 7, 2019 (KCL Strand PB605).
Let us know if you are having trouble accessing the readings, we can often help with this.
Organized by Eveliina Ilola and Henrik Sherling, affiliated with the KCL Psychiatry Society and KCL Health + Humanities Society.


{% extends "base.html" %} {% block title %}
{{ _('Back in ancient China, many people used a lengendary Gender Chart to predict and select baby’s gender. According to the legend, the Chinese Gender Calendar was buried in the royal tomb of an imperial family and was discovered more than 700 years ago. The calcultation to know if the the baby is a boy or a girl are said to be based on traditionnal Chinese beliefs like Yin-Yang, Five Elements, Eight Diagrams and time.') }}
{{ _('The chinese calendar predictor method use two values: the') }} "{{ _('Lunar age') }}" {{ _('of the mother when she got pregnant and the Chinese Lunar Month of conception. When you have these two values, all you need to do is to compute the formula (49 + Lunar Month - Lunar Age at the time of conception). If you get an odd number, it is a baby boy and if you get an even number, it is a baby girl.') }}
{{ _('Looking for an easy way to know the result? Just use our automated predictor below. We just need the birth date of the mother and the conception date. This tool works for year 2020, for year 2021 and for any year in the past !') }}
{{ _('BOY') }}    {{ _('or') }}    {{ _('GIRL') }}
发 现 性
{{ _('Short answer: not at all !') }}
{{ _('The accuracy of the Chinese Calendar predictor has been evaluated by scientific studies. For example,') }} {{ _('a study from 2003 analyzed 1,005 births in a private hospital in Dallas, Texas. An') }} {{ _('other study in 2009 even examined 38,394 births at Massachusetts General Hospital between 1995 and 2008.') }}
{{ _("In both cases, the conclusion is clear: there is no correlation between gender predicted using the Chinese lunar calendar and actual gender at birth. This just means that this method is not better than a coin toss ! So use it for fun if you like but don't rely on it !") }}
{{ _('We know how difficult it is to find reliable information on gender prediction on the internet. Many websites will tell you that some methods like Chinese Calendar or Ramzi theory are accurate even if there is no proof at all !') }}
{{ _("At Babygram, the only methods we trust to determine baby's sex with an utltrasound is the") }} {{ _('Nub Theory') }} {{ _('and our') }} {{ _('Image recognition algorithm') }}. {{ _('If you are looking for a reliable prediction based on scientific evidences, you can') }} {{ _('send your scan to our experts') }}.


Sexism, which is defined as prejudice, stereotyping, or discrimination towards a certain sex and sexuality, has become a greater problem as more people are allowed to be themselves. Sexism is not just confined to prejudice against women, but can include prejudice against the LGBTQ + A community.esent since the begginning of time. Even if we have become more progressive, there is still much room to create equality and spread love.
*Make sure you pause the video at the end of this page before continuing*
The organizations below will help allow to contribute and fix this problem:
The It Gets Better Project was created to encourage LGBTQ youths to follow their dreams. The It Gets Better Project's mission is to communicate to lesbian, gay, bisexual and transgender youth around the world that it gets better, and to create and inspire the changes needed to make it better for them.To learn more, click on the image below!
The Malala Fund was created by notable, Malala Yousefzai, to encourage girls and women to pursue their dreams and get an education. Its goal is to invest in local education leaders and programmes and advocate for more resources for education and safe schools for every child.Click the picture below to learn more!
GLSEN, which stands for the Gay, Lesbian & Straight Education Network,is an organization which strives to assure that each member of every school community is valued and respected regardless of sexual orientation or gender identity/expression. It aims to create safe educational environments for LGBT youth. Click the picture below to learn more!
Girls Who Code is a non-profit organization which tries to close the gender gap between men and women in technology. It tries to get more girls interested in computer science. People can get involved by starting a club or joining the Summer immersion Program.Click the picture below to learn more!


Detect module¶
-
infostop.detect.
best_partition
(coords, r1=10, r2=10, label_singleton=False, min_staying_time=300, max_time_between=86400, distance_function=<function haversine>, return_intervals=False, min_size=2)[source]¶ Deprecated. Use label label_trace instead.
-
infostop.detect.
get_stationary_events
(coords, r1, min_size, min_staying_time, max_time_between, distance_function)[source]¶ Reduce location trace to the sequence of stationary events.
Parameters: Returns: - stop_events (np.array (<N, 2))
- event_map (list) – Maps index to input-data indices.
-
infostop.detect.
label_distance_matrix
(D, r2, label_singleton=True)[source]¶ Infer infomap clusters from distance matrix and link distance threshold.
This function is for clustering points in any space given their pairwise distances. If you have static locations you can easily compute the distance matrix with the utils.distance_matrix function.
Parameters: - D (array-like (shape=(N, N))) – Distance matrix. Only upper triangle is considered.
- r2 (number) – Max distance between stationary points to form an edge.
- label_singleton (bool) – If True, give stationary locations that was only visited once their own label. If False, label them as outliers (-1)
Returns: out – Array of labels matching input in length. Detected stop locations are labeled from 0 and up, and typically locations with more observations have lower indices. If label_singleton=False, coordinated with no neighbors within distance r2 are labeled -1.
Return type: array-like (N, )
-
infostop.detect.
label_static_points
(coords, r2=10, label_singleton=True, distance_function=<function haversine>)[source]¶ Infer stop-location labels from static points.
- The method entils the following steps:
- Compute the pairwise distances between all stationarity event medians.
- Construct a network that links nodes (event medians) that are within r2 m.
- Cluster this network using two-level Infomap.
- Put the labels back info a vector that matches the input data in size.
Parameters: - coords (array-like (N, 2)) –
- r2 (number) – Max distance between stationary points to form an edge.
- label_singleton (bool) – If True, give stationary locations that was only visited once their own label. If False, label them as outliers (-1)
- distance_function (function) – The function to use to compute distances (can be utils.haversine, utils.euclidean)
Returns: out – Array of labels matching input in length. Detected stop locations are labeled from 0 and up, and typically locations with more observations have lower indices. If label_singleton=False, coordinated with no neighbors within distance r2 are labeled -1.
Return type: array-like (N, )
-
infostop.detect.
label_trace
(coords, r1=10, r2=10, label_singleton=False, min_staying_time=300, max_time_between=86400, distance_function=<function haversine>, return_intervals=False, min_size=2)[source]¶ Infer stop-location labels from mobility trace. Dynamic points are labeled -1.
- The method entils the following steps:
- Detect which points are stationary and store only the median (lat, lon) of each stationarity event. A point belongs to a stationarity event if it is less than r1 meters away from the median of the time-previous collection of stationary points.
- Compute the pairwise distances between all stationarity event medians.
- Construct a network that links nodes (event medians) that are within r2 m.
- Cluster this network using two-level Infomap.
- Put the labels back info a vector that matches the input data in size.
Parameters: - coords (array-like (N, 2) or (N,3)) –
- r1 (number) – Max distance between time-consecutive points to label them as stationary
- r2 (number) – Max distance between stationary points to form an edge.
- label_singleton (bool) – If True, give stationary locations that was only visited once their own label. If False, label them as outliers (-1)
- min_staying_time (int) – The shortest duration that can constitute a stop. Only used if timestamp column is provided
- max_time_between (int) – The longest duration that can constitute a stop. Only used if timestamp column is provided
- distance_function (function) – The function to use to compute distances (can be utils.haversine, utils.euclidean)
- return_intervals (bool) – If True, aggregate the final trajectory into intervals (default: False)
- min_size (int) – Minimum size of group to consider it stationary (default: 2)
Returns: out – Array of labels matching input in length. Non-stationary locations and outliers (locations visited only once if label_singleton == False) are labeled as -1. Detected stop locations are labeled from 0 and up, and typically locations with more observations have lower indices.
Return type: array-like (N, )
Utils module¶
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infostop.utils.
compute_intervals
(coords, coord_labels, max_time_between, distance_function=<function haversine>)[source]¶ Compute stop and moves intervals from the list of labels.
Parameters: - coords (array-like (shape=(N, 2) or shape=(N,3))) –
- coord_labels (list of integers) –
Returns: intervals
Return type: array-like (shape=(N_intervals,4), location, start_time, end_time, latitude, longitude)
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infostop.utils.
distance_matrix
(stop_events, distance_function=<function haversine>)[source]¶ Compute distance matrix between list of points.
Parameters: - stop_events (array-like (shape=(N, 2))) –
- distance_function (function (used to compute distances)) –
Returns: D
Return type: array-like (shape=(N, N))
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infostop.utils.
euclidean
(points_a, points_b, radians=False)[source]¶ Calculate the euclidian distance bewteen points_a and points_b points_a and points_b can be a single points or lists of points.
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infostop.utils.
general_pdist
(points, distance_function=<function haversine>)[source]¶ Calculate the distance bewteen each pair in a set of points given a distance function.
Author: Piotr Sapiezynski Source: https://github.com/sapiezynski/haversinevec
Parameters: points (array-like (shape=(N, 2))) – (lat, lon) in degree or radians (default is degree) Returns: result Return type: array-like (shape=(N*(N-1)//2, ))
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infostop.utils.
get_stationary_events
(groups, min_size=2)[source]¶ Convert groups of multiple points (stationary location events) to median-of-group points.
Parameters: - groups (list-of-list) – Each list is a group of points
- min_size (int) – Minimum size of group to consider it stationary (default: 1)
Returns: - stat_coords (array-like (M, 2)) – Medioids of stationary groups
- event_map (list) – Maps event index to input-data index. Used for mapping label ids onto each (lat, lon) point.
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infostop.utils.
group_time_distance
(coords, r_C, min_staying_time, max_staying_time, distance_function)[source]¶ Group temporally adjacent points if they are closer than r_C.
Parameters: Returns: groups – Each list is a group of points
Return type: list-of-list
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infostop.utils.
haversine
(points_a, points_b, radians=False)[source]¶ Calculate the great-circle distance bewteen points_a and points_b points_a and points_b can be a single points or lists of points.
Author: Piotr Sapiezynski Source: https://github.com/sapiezynski/haversinevec
Using this because it is vectorized (stupid fast).


Parent Property: {{contactList | json}}
Click below button to update the value from parent component, it will be detected in child component through OnChages() lifecycle hook.


The film series is set in space so colour schemes can contrast heavily with bright colours representing stars and lights on the backdrop of blackness of space. I intend to use this sort of colour scheme for both the comic strip and the website.
This includes the red and blue lights of the weapons as well as the bold Yellow of the title text. These will be used as base colours and faded gradually into white for a glowing effect.
The black background will also feature white lights to represent distant stars and worlds in this far away galaxy.
The fonts used in the website need to be bold and easy to read. The fonts in the comic strip can be a little more unorthodox to give it more of a comic strip feel.
Possible fonts to be used in both website and comic strip:
IMPACT
VERDANA
PAPYRUS
ARIAL BLACK
KRISTEN ICT