| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26828 | 534 | 26294 | 98.01 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 5489.003 | 5453.008 |
| AIC | 5489.003 | 5477.008 |
| SBC | 5489.003 | 5528.373 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 35.9956 | 12 | 0.0003 |
| Score (Model-Based) | 36.9454 | 12 | 0.0002 |
| Score (Sandwich) | 70.0522 | 12 | <.0001 |
| Wald (Model-Based) | 35.2561 | 12 | 0.0004 |
| Wald (Sandwich) | 79.9283 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 21.0816 | <.0001 |
| database | 2 | 2.4270 | 0.2972 |
| exposure*database | 4 | 11.3788 | 0.0226 |
| meanPredEqDoseCat | 4 | 5.4638 | 0.2429 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.46961 | 0.37888 | 0.473 | 15.0457 | 0.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.61169 | 0.32898 | 0.789 | 3.4572 | 0.0630 | exposure No exposure | ||||
| database | MPCD | 1 | -0.25209 | 0.61644 | 3.408 | 0.1672 | 0.6826 | database MPCD | ||||
| database | Marketscan | 1 | -0.54551 | 0.36196 | 2.407 | 2.2714 | 0.1318 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.38064 | 0.75402 | 0.641 | 0.2548 | 0.6137 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 1.23019 | 0.44400 | 0.521 | 7.6769 | 0.0056 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.37520 | 0.64459 | 1.033 | 0.3388 | 0.5605 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.15725 | 0.36164 | 0.794 | 10.2400 | 0.0014 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 1.01969 | 0.94456 | 1.686 | 1.1654 | 0.2803 | 2.772 | 0.435 | 17.654 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.24718 | 0.24882 | 1.753 | 0.9868 | 0.3205 | 0.781 | 0.480 | 1.272 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.00187 | 0.36538 | 0.831 | 0.0000 | 0.9959 | 1.002 | 0.490 | 2.050 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -0.67068 | 0.37480 | 1.072 | 3.2020 | 0.0735 | 0.511 | 0.245 | 1.066 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.337 | 0.096 | 1.177 |
| exposure No exposure vs TNF At database=MPCD | 0.789 | 0.255 | 2.448 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.787 | 0.482 | 1.285 |
| exposure No exposure vs TNF At database=Marketscan | 1.726 | 1.246 | 2.390 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.230 | 0.109 | 0.483 |
| exposure No exposure vs TNF At database=Medicare | 0.542 | 0.285 | 1.034 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27630 | 21 | 27609 | 99.92 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 385.704 | 374.996 |
| AIC | 385.704 | 390.996 |
| SBC | 385.704 | 399.352 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 10.7087 | 8 | 0.2188 |
| Score (Model-Based) | 10.0485 | 8 | 0.2616 |
| Score (Sandwich) | 17.8087 | 8 | 0.0227 |
| Wald (Model-Based) | 5.0597 | 8 | 0.7512 |
| Wald (Sandwich) | 3910.2987 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.4955 | 0.4734 |
| database | 2 | 1.6591 | 0.4362 |
| exposure*database | 4 | 967.0188 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.64797 | 1.38654 | 0.976 | 1.4126 | 0.2346 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.61299 | 1.07913 | 1.013 | 0.3227 | 0.5700 | exposure No exposure | ||||
| database | MPCD | 1 | 0.67767 | 1.21738 | 0.992 | 0.3099 | 0.5778 | database MPCD | ||||
| database | Marketscan | 1 | -0.49702 | 1.14693 | 0.991 | 0.1878 | 0.6648 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.37101 | 1.86369 | 0.996 | 0.5412 | 0.4619 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -13.11987 | 1.52639 | 0.001 | 73.8801 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -15.20827 | 1.27293 | 0.001 | 142.7418 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.90766 | 1.31349 | 1.005 | 0.4775 | 0.4895 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.758 | 0.064 | 8.984 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.343 | 0.305 | 5.905 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.192 | 0.013 | 2.914 |
| exposure No exposure vs TNF At database=Medicare | 0.542 | 0.065 | 4.491 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27630 | 21 | 27609 | 99.92 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 760.726 | 737.679 |
| AIC | 760.726 | 753.679 |
| SBC | 760.726 | 762.035 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 23.0471 | 8 | 0.0033 |
| Score (Model-Based) | 24.2771 | 8 | 0.0021 |
| Score (Sandwich) | 18.1291 | 8 | 0.0203 |
| Wald (Model-Based) | 15.7722 | 8 | 0.0458 |
| Wald (Sandwich) | 3343.1887 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.9263 | 0.3817 |
| database | 2 | 2.9841 | 0.2249 |
| exposure*database | 4 | 870.0560 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.07327 | 1.37922 | 1.234 | 0.0028 | 0.9576 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.17564 | 1.09180 | 1.784 | 1.1595 | 0.2816 | exposure No exposure | ||||
| database | MPCD | 1 | 2.16744 | 1.28287 | 2.086 | 2.8545 | 0.0911 | database MPCD | ||||
| database | Marketscan | 1 | 1.02376 | 1.19758 | 1.968 | 0.7308 | 0.3926 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.34271 | 1.91719 | 1.253 | 0.0320 | 0.8581 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -13.75365 | 1.56853 | 0.002 | 76.8864 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -15.94772 | 1.33214 | 0.002 | 143.3162 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.62462 | 1.36394 | 1.667 | 0.2097 | 0.6470 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.764 | 0.062 | 9.465 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.735 | 0.344 | 8.761 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.076 | 0.072 | 16.063 |
| exposure No exposure vs TNF At database=Medicare | 3.240 | 0.381 | 27.537 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27630 | 21 | 27609 | 99.92 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 760.726 | 728.635 |
| AIC | 760.726 | 752.635 |
| SBC | 760.726 | 765.170 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 32.0906 | 12 | 0.0013 |
| Score (Model-Based) | 34.1443 | 12 | 0.0006 |
| Score (Sandwich) | 18.6568 | 12 | 0.0972 |
| Wald (Model-Based) | 22.2990 | 12 | 0.0343 |
| Wald (Sandwich) | 3979.1362 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.0533 | 0.3582 |
| database | 2 | 3.2122 | 0.2007 |
| exposure*database | 4 | 973.7364 | <.0001 |
| meanPredEqDoseCat | 4 | 1645.9810 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.06430 | 1.38974 | 1.243 | 0.0021 | 0.9631 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.19660 | 1.08177 | 1.772 | 1.2236 | 0.2687 | exposure No exposure | ||||
| database | MPCD | 1 | 2.27197 | 1.30850 | 2.116 | 3.0148 | 0.0825 | database MPCD | ||||
| database | Marketscan | 1 | 1.05837 | 1.23200 | 2.018 | 0.7380 | 0.3903 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.42301 | 1.92275 | 1.257 | 0.0484 | 0.8259 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -14.64675 | 1.56091 | 0.001 | 88.0499 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -17.17198 | 1.39433 | 0.001 | 151.6729 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.64272 | 1.39331 | 1.704 | 0.2128 | 0.6446 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -14.29867 | 0.71424 | 0.000 | 400.7772 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.09527 | 0.71613 | 1.750 | 0.0177 | 0.8942 | 0.909 | 0.223 | 3.700 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 1.61069 | 0.80287 | 1.323 | 4.0246 | 0.0448 | 5.006 | 1.038 | 24.150 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -14.27886 | 0.42164 | 0.000 | 1146.8325 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.699 | 0.056 | 8.780 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.740 | 0.329 | 9.213 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.066 | 0.070 | 16.251 |
| exposure No exposure vs TNF At database=Medicare | 3.309 | 0.397 | 27.573 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27630 | 21 | 27609 | 99.92 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 760.726 | 730.350 |
| AIC | 760.726 | 748.350 |
| SBC | 760.726 | 757.750 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 30.3763 | 9 | 0.0004 |
| Score (Model-Based) | 31.6344 | 9 | 0.0002 |
| Score (Sandwich) | 18.6479 | 9 | 0.0284 |
| Wald (Model-Based) | 22.6020 | 9 | 0.0072 |
| Wald (Sandwich) | 3440.4306 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.1292 | 0.3449 |
| database | 2 | 2.9339 | 0.2306 |
| exposure*database | 4 | 868.6896 | <.0001 |
| SEX | 1 | 2.7474 | 0.0974 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.24307 | 1.41815 | 1.266 | 0.0294 | 0.8639 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.35340 | 1.15211 | 1.878 | 1.3800 | 0.2401 | exposure No exposure | ||||
| database | MPCD | 1 | 2.14642 | 1.27895 | 2.078 | 2.8166 | 0.0933 | database MPCD | ||||
| database | Marketscan | 1 | 1.03054 | 1.19986 | 1.969 | 0.7377 | 0.3904 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.45880 | 1.95997 | 1.281 | 0.0548 | 0.8149 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -13.85643 | 1.59874 | 0.002 | 75.1189 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -16.06961 | 1.38764 | 0.002 | 134.1088 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.80402 | 1.42289 | 1.736 | 0.3193 | 0.5720 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | -0.91342 | 0.55107 | 1.585 | 2.7474 | 0.0974 | 0.401 | 0.136 | 1.181 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.806 | 0.065 | 9.917 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.732 | 0.342 | 8.761 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.275 | 0.079 | 20.544 |
| exposure No exposure vs TNF At database=Medicare | 3.871 | 0.405 | 37.022 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27630 | 21 | 27609 | 99.92 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 760.726 | 732.911 |
| AIC | 760.726 | 750.911 |
| SBC | 760.726 | 760.312 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 27.8148 | 9 | 0.0010 |
| Score (Model-Based) | 28.1525 | 9 | 0.0009 |
| Score (Sandwich) | 18.5468 | 9 | 0.0293 |
| Wald (Model-Based) | 18.7447 | 9 | 0.0275 |
| Wald (Sandwich) | 3443.0492 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.5293 | 0.2823 |
| database | 2 | 3.0596 | 0.2166 |
| exposure*database | 4 | 833.4816 | <.0001 |
| indHospInf | 1 | 2.8588 | 0.0909 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.20387 | 1.26012 | 1.118 | 0.0262 | 0.8715 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.47967 | 1.31276 | 2.003 | 1.2704 | 0.2597 | exposure No exposure | ||||
| database | MPCD | 1 | 2.48346 | 1.46728 | 2.241 | 2.8648 | 0.0905 | database MPCD | ||||
| database | Marketscan | 1 | 1.26791 | 1.33424 | 2.116 | 0.9031 | 0.3420 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.07431 | 1.84007 | 1.198 | 0.0016 | 0.9678 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -13.48579 | 1.48909 | 0.002 | 82.0185 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -16.28115 | 1.50749 | 0.002 | 116.6444 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.85485 | 1.48598 | 1.775 | 0.3309 | 0.5651 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | 1.86033 | 1.10027 | 1.527 | 2.8588 | 0.0909 | 6.426 | 0.744 | 55.524 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.757 | 0.061 | 9.417 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.868 | 0.364 | 9.584 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.816 | 0.069 | 9.640 |
| exposure No exposure vs TNF At database=Medicare | 4.391 | 0.335 | 57.549 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27630 | 21 | 27609 | 99.92 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 760.726 | 716.538 |
| AIC | 760.726 | 744.538 |
| SBC | 760.726 | 759.162 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 44.1875 | 14 | <.0001 |
| Score (Model-Based) | 45.7203 | 14 | <.0001 |
| Score (Sandwich) | 19.4123 | 14 | 0.1498 |
| Wald (Model-Based) | 33.1273 | 14 | 0.0028 |
| Wald (Sandwich) | 4225.7322 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.8384 | 0.2419 |
| database | 2 | 3.3183 | 0.1903 |
| exposure*database | 4 | 933.5887 | <.0001 |
| meanPredEqDoseCat | 4 | 2194.7413 | <.0001 |
| SEX | 1 | 2.9762 | 0.0845 |
| indHospInf | 1 | 2.9377 | 0.0865 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.17968 | 1.25020 | 1.098 | 0.0207 | 0.8857 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.64116 | 1.31560 | 2.030 | 1.5562 | 0.2122 | exposure No exposure | ||||
| database | MPCD | 1 | 2.50926 | 1.42498 | 2.194 | 3.1008 | 0.0783 | database MPCD | ||||
| database | Marketscan | 1 | 1.25805 | 1.31822 | 2.110 | 0.9108 | 0.3399 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.12217 | 1.82426 | 1.182 | 0.0045 | 0.9466 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -14.30974 | 1.47279 | 0.001 | 94.4026 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -17.66232 | 1.57112 | 0.001 | 126.3793 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.99848 | 1.53386 | 1.843 | 0.4237 | 0.5151 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -14.27657 | 0.84810 | 0.000 | 283.3715 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.06534 | 0.71223 | 1.728 | 0.0084 | 0.9269 | 0.937 | 0.232 | 3.783 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 1.49325 | 0.83890 | 1.368 | 3.1684 | 0.0751 | 4.452 | 0.860 | 23.045 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -14.39231 | 0.37278 | 0.000 | 1490.6152 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | -0.91538 | 0.53061 | 1.521 | 2.9762 | 0.0845 | 0.400 | 0.142 | 1.133 | Administrative Sex F | |
| indHospInf | 1 | 1.98569 | 1.15854 | 1.590 | 2.9377 | 0.0865 | 7.284 | 0.752 | 70.554 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.739 | 0.059 | 9.260 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.902 | 0.354 | 10.214 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.836 | 0.072 | 9.686 |
| exposure No exposure vs TNF At database=Medicare | 5.161 | 0.392 | 68.012 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27630 | 21 | 27609 | 99.92 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 178.355 | 167.394 |
| AIC | 178.355 | 191.394 |
| SBC | 178.355 | 203.928 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 10.9608 | 12 | 0.5323 |
| Score (Model-Based) | 12.7489 | 12 | 0.3876 |
| Score (Sandwich) | 19.7156 | 12 | 0.0727 |
| Wald (Model-Based) | 8.5883 | 12 | 0.7376 |
| Wald (Sandwich) | 4425.6157 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 3.0806 | 0.2143 |
| database | 2 | 3.4048 | 0.1822 |
| exposure*database | 4 | 982.9690 | <.0001 |
| meanPredEqDoseCat | 4 | 976.2190 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.00619 | 1.41457 | 0.291 | 0.0000 | 0.9965 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.37694 | 1.05546 | 0.455 | 1.7020 | 0.1920 | exposure No exposure | ||||
| database | MPCD | 1 | 2.30441 | 1.29349 | 0.861 | 3.1739 | 0.0748 | database MPCD | ||||
| database | Marketscan | 1 | 1.03742 | 1.22133 | 0.812 | 0.7215 | 0.3956 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.43591 | 1.92185 | 0.359 | 0.0514 | 0.8206 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -14.69153 | 1.56343 | 0.001 | 88.3035 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -17.32782 | 1.34725 | 0.000 | 165.4208 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.80154 | 1.36587 | 0.537 | 0.3444 | 0.5573 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -15.86371 | 1.03956 | 0.000 | 232.8664 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -1.08549 | 0.85678 | 0.792 | 1.6051 | 0.2052 | 0.338 | 0.063 | 1.811 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 1.96007 | 0.90297 | 0.856 | 4.7119 | 0.0300 | 7.100 | 1.210 | 41.673 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -15.63953 | 0.60467 | 0.000 | 668.9692 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.643 | 0.052 | 7.924 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.778 | 0.336 | 9.421 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.994 | 0.062 | 15.900 |
| exposure No exposure vs TNF At database=Medicare | 3.963 | 0.501 | 31.362 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27645 | 12 | 27633 | 99.96 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 229.108 | 213.872 |
| AIC | 229.108 | 229.872 |
| SBC | 229.108 | 233.752 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 15.2355 | 8 | 0.0547 |
| Score (Model-Based) | 16.3395 | 8 | 0.0378 |
| Score (Sandwich) | 11.8983 | 8 | 0.1558 |
| Wald (Model-Based) | 5.1859 | 8 | 0.7375 |
| Wald (Sandwich) | 3136.6683 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1684.1751 | <.0001 |
| database | 2 | 3.4596 | 0.1773 |
| exposure*database | 4 | 1982.8950 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -17.04427 | 1.00879 | 0.001 | 285.4653 | <.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.51797 | 1.06928 | 0.992 | 0.2347 | 0.6281 | exposure No exposure | ||||
| database | MPCD | 1 | 0.55163 | 1.21984 | 0.995 | 0.2045 | 0.6511 | database MPCD | ||||
| database | Marketscan | 1 | -1.71508 | 1.40640 | 0.994 | 1.4871 | 0.2227 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.65479 | 1.23373 | 0.000 | 0.2817 | 0.5956 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 1.51318 | 1.42454 | 0.000 | 1.1283 | 0.2881 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -16.80037 | 1.28836 | 0.000 | 170.0451 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.61356 | 1.83107 | 1.031 | 0.1123 | 0.7376 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.100 | 0.071 | 17.148 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Medicare | 0.596 | 0.073 | 4.844 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27645 | 12 | 27633 | 99.96 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2673.970 | 2465.484 |
| AIC | 2673.970 | 2481.484 |
| SBC | 2673.970 | 2485.363 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 208.4858 | 8 | <.0001 |
| Score (Model-Based) | 203.3295 | 8 | <.0001 |
| Score (Sandwich) | 11.1836 | 8 | 0.1915 |
| Wald (Model-Based) | 60.5454 | 8 | <.0001 |
| Wald (Sandwich) | 2385.4298 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1672.4820 | <.0001 |
| database | 2 | 9.9294 | 0.0070 |
| exposure*database | 4 | 1623.3699 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -16.08975 | 0.98100 | 0.002 | 269.0031 | <.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.80835 | 1.01950 | 2.648 | 3.1462 | 0.0761 | exposure No exposure | ||||
| database | MPCD | 1 | -0.85062 | 1.23577 | 4.067 | 0.4738 | 0.4912 | database MPCD | ||||
| database | Marketscan | 1 | -4.12201 | 1.40365 | 1.702 | 8.6239 | 0.0033 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.84737 | 1.25722 | 0.001 | 0.4543 | 0.5003 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 4.11859 | 1.41802 | 0.002 | 8.4360 | 0.0037 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -13.42511 | 1.27970 | 0.001 | 110.0579 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 2.68080 | 1.76731 | 1.342 | 2.3009 | 0.1293 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.393 | 0.150 | 38.152 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Medicare | 0.164 | 0.022 | 1.209 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27645 | 12 | 27633 | 99.96 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2673.970 | 2411.155 |
| AIC | 2673.970 | 2435.155 |
| SBC | 2673.970 | 2440.974 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 262.8147 | 12 | <.0001 |
| Score (Model-Based) | 246.0928 | 12 | <.0001 |
| Score (Sandwich) | 11.6485 | 12 | 0.4743 |
| Wald (Model-Based) | 87.9005 | 12 | <.0001 |
| Wald (Sandwich) | 2571.2659 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1703.8589 | <.0001 |
| database | 2 | 9.8031 | 0.0074 |
| exposure*database | 4 | 1709.2970 | <.0001 |
| meanPredEqDoseCat | 4 | 686.2597 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -16.06477 | 0.97662 | 0.002 | 270.5804 | <.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.87277 | 1.03260 | 2.683 | 3.2893 | 0.0697 | exposure No exposure | ||||
| database | MPCD | 1 | -0.78084 | 1.21203 | 3.981 | 0.4151 | 0.5194 | database MPCD | ||||
| database | Marketscan | 1 | -4.12399 | 1.40589 | 1.705 | 8.6046 | 0.0034 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.83629 | 1.25165 | 0.001 | 0.4464 | 0.5040 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 4.16989 | 1.42530 | 0.002 | 8.5592 | 0.0034 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -13.72971 | 1.23655 | 0.001 | 123.2810 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 2.63499 | 1.76388 | 1.340 | 2.2316 | 0.1352 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0.40988 | 1.37012 | 1.660 | 0.0895 | 0.7648 | 1.507 | 0.103 | 22.093 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -1.81770 | 1.14037 | 2.824 | 2.5407 | 0.1109 | 0.162 | 0.017 | 1.518 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -14.74949 | 0.97458 | 0.001 | 229.0454 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -2.49142 | 1.31064 | 1.313 | 3.6135 | 0.0573 | 0.083 | 0.006 | 1.080 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.143 | 0.134 | 34.304 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Medicare | 0.154 | 0.020 | 1.163 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27645 | 12 | 27633 | 99.96 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2673.970 | 2415.940 |
| AIC | 2673.970 | 2433.940 |
| SBC | 2673.970 | 2438.305 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 258.0293 | 9 | <.0001 |
| Score (Model-Based) | 247.8345 | 9 | <.0001 |
| Score (Sandwich) | 11.1870 | 9 | 0.2631 |
| Wald (Model-Based) | 97.5072 | 9 | <.0001 |
| Wald (Sandwich) | 2390.2968 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1637.1044 | <.0001 |
| database | 2 | 9.8945 | 0.0071 |
| exposure*database | 4 | 1613.3679 | <.0001 |
| SEX | 1 | 1.9501 | 0.1626 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -16.30516 | 1.03971 | 0.002 | 245.9374 | <.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.96530 | 1.06883 | 2.769 | 3.3810 | 0.0660 | exposure No exposure | ||||
| database | MPCD | 1 | -0.83829 | 1.23435 | 4.062 | 0.4612 | 0.4971 | database MPCD | ||||
| database | Marketscan | 1 | -4.10098 | 1.39356 | 1.690 | 8.6601 | 0.0033 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.01353 | 1.31474 | 0.001 | 0.5943 | 0.4408 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 4.25487 | 1.44362 | 0.002 | 8.6870 | 0.0032 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -13.27493 | 1.34016 | 0.001 | 98.1189 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 2.85078 | 1.80842 | 1.373 | 2.4850 | 0.1149 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | 1.53371 | 1.09828 | 4.289 | 1.9501 | 0.1626 | 4.635 | 0.539 | 39.897 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.424 | 0.152 | 38.658 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Medicare | 0.140 | 0.017 | 1.138 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27645 | 12 | 27633 | 99.96 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2673.970 | 2448.715 |
| AIC | 2673.970 | 2466.715 |
| SBC | 2673.970 | 2471.079 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 225.2544 | 9 | <.0001 |
| Score (Model-Based) | 216.6755 | 9 | <.0001 |
| Score (Sandwich) | 11.1849 | 9 | 0.2632 |
| Wald (Model-Based) | 64.8336 | 9 | <.0001 |
| Wald (Sandwich) | 2525.5290 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1620.7919 | <.0001 |
| database | 2 | 10.0924 | 0.0064 |
| exposure*database | 4 | 1577.8914 | <.0001 |
| indHospInf | 1 | 206.6774 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -15.93220 | 0.98187 | 0.002 | 263.2954 | <.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.88789 | 1.02007 | 2.650 | 3.4252 | 0.0642 | exposure No exposure | ||||
| database | MPCD | 1 | -0.93031 | 1.23609 | 4.068 | 0.5664 | 0.4517 | database MPCD | ||||
| database | Marketscan | 1 | -4.18579 | 1.40381 | 1.702 | 8.8907 | 0.0029 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.61667 | 1.25893 | 0.001 | 0.2399 | 0.6243 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 3.91845 | 1.41907 | 0.002 | 7.6247 | 0.0058 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -13.42894 | 1.28022 | 0.001 | 110.0313 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 2.74369 | 1.76694 | 1.342 | 2.4112 | 0.1205 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | -14.70312 | 1.02273 | 0.002 | 206.6774 | <.0001 | 0.000 | 0.000 | 0.000 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.353 | 0.148 | 37.533 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Medicare | 0.151 | 0.021 | 1.118 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27645 | 12 | 27633 | 99.96 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2673.970 | 2328.935 |
| AIC | 2673.970 | 2356.935 |
| SBC | 2673.970 | 2363.724 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 345.0349 | 14 | <.0001 |
| Score (Model-Based) | 310.8194 | 14 | <.0001 |
| Score (Sandwich) | 11.6711 | 14 | 0.6327 |
| Wald (Model-Based) | 143.0512 | 14 | <.0001 |
| Wald (Sandwich) | 2933.9384 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1833.8231 | <.0001 |
| database | 2 | 10.1918 | 0.0061 |
| exposure*database | 4 | 1876.7630 | <.0001 |
| meanPredEqDoseCat | 4 | 702.3175 | <.0001 |
| SEX | 1 | 2.5076 | 0.1133 |
| indHospInf | 1 | 180.8023 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -17.20829 | 1.06338 | 0.001 | 261.8755 | <.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -2.19497 | 1.10837 | 2.867 | 3.9218 | 0.0477 | exposure No exposure | ||||
| database | MPCD | 1 | -0.76694 | 1.18654 | 3.898 | 0.4178 | 0.5180 | database MPCD | ||||
| database | Marketscan | 1 | -4.21100 | 1.41935 | 1.721 | 8.8022 | 0.0030 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.71244 | 1.26017 | 0.001 | 0.3196 | 0.5718 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 4.18740 | 1.47982 | 0.001 | 8.0070 | 0.0047 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -14.63901 | 1.27197 | 0.001 | 132.4565 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 2.93600 | 1.81894 | 1.381 | 2.6054 | 0.1065 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0.06937 | 1.54632 | 1.875 | 0.0020 | 0.9642 | 1.072 | 0.052 | 22.200 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -1.97324 | 1.18382 | 2.928 | 2.7784 | 0.0955 | 0.139 | 0.014 | 1.415 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -15.79077 | 1.05904 | 0.001 | 222.3207 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -2.79480 | 1.37018 | 1.371 | 4.1605 | 0.0414 | 0.061 | 0.004 | 0.896 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | 1.78191 | 1.12527 | 4.382 | 2.5076 | 0.1133 | 5.941 | 0.655 | 53.915 | Administrative Sex F | |
| indHospInf | 1 | -15.74870 | 1.17123 | 0.001 | 180.8023 | <.0001 | 0.000 | 0.000 | 0.000 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.098 | 0.131 | 33.485 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Medicare | 0.111 | 0.013 | 0.978 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27645 | 12 | 27633 | 99.96 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 377.895 | 329.174 |
| AIC | 377.895 | 353.174 |
| SBC | 377.895 | 358.993 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 48.7206 | 12 | <.0001 |
| Score (Model-Based) | 55.0792 | 12 | <.0001 |
| Score (Sandwich) | 11.8832 | 12 | 0.4551 |
| Wald (Model-Based) | 18.0767 | 12 | 0.1134 |
| Wald (Sandwich) | 3160.7086 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1868.0815 | <.0001 |
| database | 2 | 9.7775 | 0.0075 |
| exposure*database | 4 | 1734.3811 | <.0001 |
| meanPredEqDoseCat | 4 | 507.1620 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -16.46446 | 0.93471 | 0.000 | 310.2692 | <.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.85842 | 1.04119 | 0.502 | 3.1859 | 0.0743 | exposure No exposure | ||||
| database | MPCD | 1 | -0.81437 | 1.20384 | 2.429 | 0.4576 | 0.4987 | database MPCD | ||||
| database | Marketscan | 1 | -4.15285 | 1.39675 | 1.083 | 8.8400 | 0.0029 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.82618 | 1.27672 | 0.000 | 0.4188 | 0.5176 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 3.69246 | 1.43427 | 0.000 | 6.6278 | 0.0100 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -14.02385 | 1.23289 | 0.000 | 129.3863 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 2.63558 | 1.77596 | 0.559 | 2.2023 | 0.1378 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 1.18207 | 1.35845 | 1.053 | 0.7572 | 0.3842 | 3.261 | 0.228 | 46.739 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.95374 | 1.17853 | 1.708 | 0.6549 | 0.4184 | 0.385 | 0.038 | 3.881 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -14.61450 | 0.94956 | 0.000 | 236.8767 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -4.26024 | 1.28422 | 0.233 | 11.0050 | 0.0009 | 0.014 | 0.001 | 0.175 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=MPCD | 0.000 | 0.000 | 0.000 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.175 | 0.136 | 34.818 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Medicare | 0.156 | 0.020 | 1.200 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27597 | 49 | 27548 | 99.82 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 892.028 | 858.598 |
| AIC | 892.028 | 874.598 |
| SBC | 892.028 | 889.732 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 33.4306 | 8 | <.0001 |
| Score (Model-Based) | 25.8099 | 8 | 0.0011 |
| Score (Sandwich) | 41.9326 | 8 | <.0001 |
| Wald (Model-Based) | 10.2956 | 8 | 0.2449 |
| Wald (Sandwich) | 9954.4388 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.9390 | 0.3793 |
| database | 2 | 968.0087 | <.0001 |
| exposure*database | 4 | 1053.6946 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.88741 | 0.70566 | 1.016 | 1.5815 | 0.2086 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.31777 | 0.61427 | 1.009 | 0.2676 | 0.6049 | exposure No exposure | ||||
| database | MPCD | 1 | -16.32472 | 0.58161 | 0.000 | 787.8305 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -2.75452 | 1.15596 | 1.001 | 5.6781 | 0.0172 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.79189 | 0.69435 | 0.000 | 1.3007 | 0.2541 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -12.78024 | 1.21425 | 0.001 | 110.7807 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.41301 | 0.60842 | 0.000 | 0.4608 | 0.4972 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.72492 | 1.27557 | 1.003 | 1.8286 | 0.1763 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.909 | 0.747 | 1.106 |
| exposure No exposure vs TNF At database=MPCD | 1.100 | 0.953 | 1.270 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 4.084 | 0.459 | 36.378 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.412 | 0.103 | 1.642 |
| exposure No exposure vs TNF At database=Medicare | 0.728 | 0.218 | 2.426 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27597 | 49 | 27548 | 99.82 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2419.843 | 2329.530 |
| AIC | 2419.843 | 2345.530 |
| SBC | 2419.843 | 2360.665 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 90.3132 | 8 | <.0001 |
| Score (Model-Based) | 74.3128 | 8 | <.0001 |
| Score (Sandwich) | 43.1348 | 8 | <.0001 |
| Wald (Model-Based) | 34.8127 | 8 | <.0001 |
| Wald (Sandwich) | 8933.5918 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.7147 | 0.4243 |
| database | 2 | 534.1714 | <.0001 |
| exposure*database | 4 | 884.0901 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.76554 | 0.79718 | 2.025 | 0.9222 | 0.3369 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.23788 | 0.78450 | 3.666 | 0.0919 | 0.7617 | exposure No exposure | ||||
| database | MPCD | 1 | -15.05316 | 0.79031 | 0.002 | 362.7974 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.93056 | 1.28801 | 3.468 | 2.2466 | 0.1339 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.70289 | 0.88998 | 0.001 | 0.6238 | 0.4297 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -12.42079 | 1.36418 | 0.002 | 82.9005 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.25378 | 0.75917 | 0.001 | 0.1117 | 0.7382 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.81318 | 1.38031 | 2.300 | 0.3471 | 0.5558 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.939 | 0.621 | 1.420 |
| exposure No exposure vs TNF At database=MPCD | 1.016 | 0.772 | 1.338 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.778 | 0.201 | 15.694 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.465 | 0.097 | 2.219 |
| exposure No exposure vs TNF At database=Medicare | 0.788 | 0.169 | 3.668 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27597 | 49 | 27548 | 99.82 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2419.843 | 2270.698 |
| AIC | 2419.843 | 2294.698 |
| SBC | 2419.843 | 2317.399 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 149.1458 | 12 | <.0001 |
| Score (Model-Based) | 143.4585 | 12 | <.0001 |
| Score (Sandwich) | 44.7684 | 12 | <.0001 |
| Wald (Model-Based) | 93.4571 | 12 | <.0001 |
| Wald (Sandwich) | 9293.9953 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.3109 | 0.3149 |
| database | 2 | 511.0193 | <.0001 |
| exposure*database | 4 | 846.2838 | <.0001 |
| meanPredEqDoseCat | 4 | 6.8388 | 0.1447 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.80223 | 0.80160 | 2.038 | 1.0016 | 0.3169 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.15924 | 0.74747 | 3.480 | 0.0454 | 0.8313 | exposure No exposure | ||||
| database | MPCD | 1 | -15.08338 | 0.82315 | 0.002 | 335.7696 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.96907 | 1.31815 | 3.547 | 2.2315 | 0.1352 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.67111 | 0.85672 | 0.001 | 0.6136 | 0.4334 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -12.46014 | 1.34486 | 0.002 | 85.8407 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.39980 | 0.89108 | 0.001 | 0.2013 | 0.6537 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.90452 | 1.41322 | 2.354 | 0.4097 | 0.5221 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 1.29699 | 1.13994 | 1.163 | 1.2945 | 0.2552 | 3.658 | 0.392 | 34.166 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 1.45393 | 0.83132 | 4.220 | 3.0587 | 0.0803 | 4.280 | 0.839 | 21.830 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 1.55888 | 0.91689 | 2.279 | 2.8906 | 0.0891 | 4.753 | 0.788 | 28.673 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.60636 | 0.52900 | 1.243 | 1.3139 | 0.2517 | 1.834 | 0.650 | 5.172 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.877 | 0.604 | 1.274 |
| exposure No exposure vs TNF At database=MPCD | 1.272 | 0.837 | 1.933 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.107 | 0.227 | 19.600 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.448 | 0.093 | 2.157 |
| exposure No exposure vs TNF At database=Medicare | 0.853 | 0.197 | 3.691 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27597 | 49 | 27548 | 99.82 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2419.843 | 2305.472 |
| AIC | 2419.843 | 2323.472 |
| SBC | 2419.843 | 2340.499 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 114.3709 | 9 | <.0001 |
| Score (Model-Based) | 96.1499 | 9 | <.0001 |
| Score (Sandwich) | 43.1431 | 9 | <.0001 |
| Wald (Model-Based) | 55.2298 | 9 | <.0001 |
| Wald (Sandwich) | 8772.6317 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.9131 | 0.3842 |
| database | 2 | 566.8937 | <.0001 |
| exposure*database | 4 | 882.5125 | <.0001 |
| SEX | 1 | 1.8923 | 0.1689 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.90672 | 0.83826 | 2.127 | 1.1700 | 0.2794 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.38853 | 0.84441 | 3.900 | 0.2117 | 0.6454 | exposure No exposure | ||||
| database | MPCD | 1 | -14.99899 | 0.76109 | 0.002 | 388.3727 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.92377 | 1.28248 | 3.454 | 2.2501 | 0.1336 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.75567 | 0.90437 | 0.001 | 0.6982 | 0.4034 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -12.34565 | 1.37417 | 0.002 | 80.7134 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.32625 | 0.77762 | 0.001 | 0.1760 | 0.6748 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.96465 | 1.40607 | 2.340 | 0.4707 | 0.4927 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | 1.02672 | 0.74637 | 3.279 | 1.8923 | 0.1689 | 2.792 | 0.647 | 12.056 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.860 | 0.598 | 1.237 |
| exposure No exposure vs TNF At database=MPCD | 0.940 | 0.668 | 1.321 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.779 | 0.202 | 15.692 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.404 | 0.078 | 2.088 |
| exposure No exposure vs TNF At database=Medicare | 0.678 | 0.130 | 3.548 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27597 | 49 | 27548 | 99.82 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2419.843 | 2329.395 |
| AIC | 2419.843 | 2347.395 |
| SBC | 2419.843 | 2364.422 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 90.4479 | 9 | <.0001 |
| Score (Model-Based) | 74.5284 | 9 | <.0001 |
| Score (Sandwich) | 44.8019 | 9 | <.0001 |
| Wald (Model-Based) | 34.9718 | 9 | <.0001 |
| Wald (Sandwich) | 9416.3557 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.8316 | 0.4002 |
| database | 2 | 494.0735 | <.0001 |
| exposure*database | 4 | 881.7188 | <.0001 |
| indHospInf | 1 | 0.0173 | 0.8953 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.77991 | 0.76410 | 1.931 | 1.0418 | 0.3074 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.22750 | 0.82025 | 3.796 | 0.0769 | 0.7815 | exposure No exposure | ||||
| database | MPCD | 1 | -15.04408 | 0.83107 | 0.002 | 327.6830 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.92196 | 1.30736 | 3.513 | 2.1612 | 0.1415 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.71728 | 0.85797 | 0.001 | 0.6989 | 0.4031 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -12.40880 | 1.34487 | 0.002 | 85.1338 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.24356 | 0.79442 | 0.001 | 0.0940 | 0.7592 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.80517 | 1.39516 | 2.323 | 0.3331 | 0.5639 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | 0.15886 | 1.20739 | 2.851 | 0.0173 | 0.8953 | 1.172 | 0.110 | 12.495 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.939 | 0.621 | 1.420 |
| exposure No exposure vs TNF At database=MPCD | 1.016 | 0.772 | 1.338 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 1.782 | 0.202 | 15.744 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.458 | 0.103 | 2.050 |
| exposure No exposure vs TNF At database=Medicare | 0.797 | 0.160 | 3.976 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27597 | 49 | 27548 | 99.82 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 2419.843 | 2252.988 |
| AIC | 2419.843 | 2280.988 |
| SBC | 2419.843 | 2307.474 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 166.8553 | 14 | <.0001 |
| Score (Model-Based) | 159.5309 | 14 | <.0001 |
| Score (Sandwich) | 44.9042 | 14 | <.0001 |
| Wald (Model-Based) | 108.5896 | 14 | <.0001 |
| Wald (Sandwich) | 9229.7429 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.2749 | 0.3206 |
| database | 2 | 435.4774 | <.0001 |
| exposure*database | 4 | 845.2604 | <.0001 |
| meanPredEqDoseCat | 4 | 7.2394 | 0.1238 |
| SEX | 1 | 1.7174 | 0.1900 |
| indHospInf | 1 | 0.0017 | 0.9670 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.87713 | 0.78109 | 1.974 | 1.2610 | 0.2615 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.25816 | 0.81292 | 3.716 | 0.1009 | 0.7508 | exposure No exposure | ||||
| database | MPCD | 1 | -15.03590 | 0.89320 | 0.002 | 283.3762 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.94255 | 1.32563 | 3.559 | 2.1473 | 0.1428 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.67347 | 0.87391 | 0.001 | 0.5939 | 0.4409 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -12.45519 | 1.30757 | 0.002 | 90.7341 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.42265 | 0.95947 | 0.001 | 0.1940 | 0.6596 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.00010 | 1.43140 | 2.381 | 0.4882 | 0.4847 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 1.04730 | 1.19988 | 1.222 | 0.7618 | 0.3828 | 2.850 | 0.271 | 29.935 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 1.38074 | 0.78200 | 3.950 | 3.1175 | 0.0775 | 3.978 | 0.859 | 18.420 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 1.46575 | 0.88406 | 2.190 | 2.7489 | 0.0973 | 4.331 | 0.766 | 24.495 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.48643 | 0.54069 | 1.265 | 0.8094 | 0.3683 | 1.627 | 0.564 | 4.693 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | 0.89055 | 0.67956 | 2.981 | 1.7174 | 0.1900 | 2.436 | 0.643 | 9.230 | Administrative Sex F | |
| indHospInf | 1 | -0.04999 | 1.20843 | 2.847 | 0.0017 | 0.9670 | 0.951 | 0.089 | 10.160 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.816 | 0.521 | 1.277 |
| exposure No exposure vs TNF At database=MPCD | 1.179 | 0.749 | 1.856 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.100 | 0.226 | 19.528 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.416 | 0.090 | 1.923 |
| exposure No exposure vs TNF At database=Medicare | 0.772 | 0.157 | 3.800 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27597 | 49 | 27548 | 99.82 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 252.055 | 226.311 |
| AIC | 252.055 | 250.311 |
| SBC | 252.055 | 273.012 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 25.7439 | 12 | 0.0117 |
| Score (Model-Based) | 29.8817 | 12 | 0.0029 |
| Score (Sandwich) | 47.8929 | 12 | <.0001 |
| Wald (Model-Based) | 16.5450 | 12 | 0.1675 |
| Wald (Sandwich) | 12206.9064 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 3.4162 | 0.1812 |
| database | 2 | 626.3120 | <.0001 |
| exposure*database | 4 | 1025.6906 | <.0001 |
| meanPredEqDoseCat | 4 | 7.0533 | 0.1331 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.85426 | 0.79069 | 0.447 | 1.1673 | 0.2800 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.05969 | 0.76132 | 0.759 | 0.0061 | 0.9375 | exposure No exposure | ||||
| database | MPCD | 1 | -16.75709 | 0.83902 | 0.001 | 398.8886 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.99557 | 1.32962 | 2.071 | 2.2526 | 0.1334 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.71530 | 0.86407 | 0.000 | 0.6853 | 0.4078 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -14.02947 | 1.33876 | 0.001 | 109.8195 | <.0001 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.20326 | 0.94838 | 0.000 | 0.0459 | 0.8303 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.80841 | 1.46765 | 0.996 | 0.3034 | 0.5818 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.16074 | 1.23400 | 0.229 | 0.0170 | 0.8964 | 0.852 | 0.076 | 9.563 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 1.27002 | 1.07813 | 1.951 | 1.3876 | 0.2388 | 3.561 | 0.430 | 29.463 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 1.49680 | 1.10278 | 0.947 | 1.8423 | 0.1747 | 4.467 | 0.514 | 38.792 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -0.73979 | 0.73648 | 0.339 | 1.0090 | 0.3151 | 0.477 | 0.113 | 2.021 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.870 | 0.593 | 1.278 |
| exposure No exposure vs TNF At database=MPCD | 1.154 | 0.689 | 1.935 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.000 | 0.000 | 0.000 |
| exposure No exposure vs TNF At database=Marketscan | 2.114 | 0.213 | 20.981 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.426 | 0.090 | 2.005 |
| exposure No exposure vs TNF At database=Medicare | 0.942 | 0.212 | 4.189 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27268 | 421 | 26847 | 98.46 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 7687.004 | 7565.910 |
| AIC | 7687.004 | 7581.910 |
| SBC | 7687.004 | 7614.251 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 121.0942 | 8 | <.0001 |
| Score (Model-Based) | 107.0761 | 8 | <.0001 |
| Score (Sandwich) | 132.7003 | 8 | <.0001 |
| Wald (Model-Based) | 90.2625 | 8 | <.0001 |
| Wald (Sandwich) | 82.1389 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 5.5975 | 0.0609 |
| database | 2 | 15.2605 | 0.0005 |
| exposure*database | 4 | 6.5935 | 0.1590 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.12623 | 0.30306 | 0.994 | 0.1735 | 0.6770 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.23021 | 0.28703 | 1.004 | 0.6433 | 0.4225 | exposure No exposure | ||||
| database | MPCD | 1 | -2.66644 | 1.03673 | 0.999 | 6.6150 | 0.0101 | database MPCD | ||||
| database | Marketscan | 1 | -1.20440 | 0.35237 | 0.998 | 11.6827 | 0.0006 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.87300 | 1.15657 | 0.998 | 2.6226 | 0.1054 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -0.39832 | 0.51333 | 0.997 | 0.6021 | 0.4378 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.64860 | 1.07689 | 0.998 | 2.3436 | 0.1258 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.38529 | 0.39273 | 0.997 | 0.9625 | 0.3266 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 5.736 | 0.643 | 51.153 |
| exposure No exposure vs TNF At database=MPCD | 6.546 | 0.852 | 50.316 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.592 | 0.262 | 1.335 |
| exposure No exposure vs TNF At database=Marketscan | 1.851 | 1.084 | 3.161 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.881 | 0.487 | 1.596 |
| exposure No exposure vs TNF At database=Medicare | 1.259 | 0.717 | 2.210 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27268 | 421 | 26847 | 98.46 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 14444.437 | 14307.946 |
| AIC | 14444.437 | 14323.946 |
| SBC | 14444.437 | 14356.287 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 136.4909 | 8 | <.0001 |
| Score (Model-Based) | 130.5550 | 8 | <.0001 |
| Score (Sandwich) | 70.2976 | 8 | <.0001 |
| Wald (Model-Based) | 120.3389 | 8 | <.0001 |
| Wald (Sandwich) | 53.4432 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.3146 | 0.3143 |
| database | 2 | 3.3804 | 0.1845 |
| exposure*database | 4 | 7.1079 | 0.1303 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.43428 | 0.36785 | 2.585 | 1.3938 | 0.2378 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.52189 | 0.34363 | 3.514 | 2.3067 | 0.1288 | exposure No exposure | ||||
| database | MPCD | 1 | 0.21190 | 1.02269 | 6.888 | 0.0429 | 0.8359 | database MPCD | ||||
| database | Marketscan | 1 | -0.68454 | 0.41579 | 3.038 | 2.7106 | 0.0997 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.82887 | 1.15773 | 2.606 | 0.5126 | 0.4740 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -1.01665 | 0.56007 | 1.513 | 3.2951 | 0.0695 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -1.21698 | 1.00712 | 3.100 | 1.4602 | 0.2269 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.01953 | 0.44327 | 2.119 | 0.0019 | 0.9648 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.674 | 0.084 | 5.407 |
| exposure No exposure vs TNF At database=MPCD | 0.499 | 0.067 | 3.712 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.559 | 0.241 | 1.293 |
| exposure No exposure vs TNF At database=Marketscan | 1.653 | 0.929 | 2.940 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.544 | 0.751 | 3.175 |
| exposure No exposure vs TNF At database=Medicare | 1.685 | 0.859 | 3.305 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27268 | 421 | 26847 | 98.46 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 14444.437 | 14286.360 |
| AIC | 14444.437 | 14310.360 |
| SBC | 14444.437 | 14358.871 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 158.0776 | 12 | <.0001 |
| Score (Model-Based) | 153.0096 | 12 | <.0001 |
| Score (Sandwich) | 88.1073 | 12 | <.0001 |
| Wald (Model-Based) | 142.4556 | 12 | <.0001 |
| Wald (Sandwich) | 64.7666 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.4226 | 0.2978 |
| database | 2 | 3.3796 | 0.1846 |
| exposure*database | 4 | 7.2153 | 0.1249 |
| meanPredEqDoseCat | 4 | 3.5314 | 0.4731 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.42415 | 0.37134 | 2.610 | 1.3046 | 0.2534 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.52975 | 0.34209 | 3.493 | 2.3981 | 0.1215 | exposure No exposure | ||||
| database | MPCD | 1 | 0.19716 | 1.03176 | 6.947 | 0.0365 | 0.8485 | database MPCD | ||||
| database | Marketscan | 1 | -0.69432 | 0.42103 | 3.074 | 2.7195 | 0.0991 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.82342 | 1.16101 | 2.613 | 0.5030 | 0.4782 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -1.02285 | 0.55760 | 1.506 | 3.3650 | 0.0666 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -1.15462 | 1.03929 | 3.195 | 1.2343 | 0.2666 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.0005173 | 0.44758 | 2.139 | 0.0000 | 0.9991 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.24477 | 0.79396 | 1.155 | 0.0950 | 0.7579 | 0.783 | 0.165 | 3.711 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.30537 | 0.28928 | 3.379 | 1.1144 | 0.2911 | 1.357 | 0.770 | 2.393 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.45233 | 0.43628 | 1.303 | 1.0749 | 0.2998 | 0.636 | 0.271 | 1.496 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.44960 | 0.43246 | 2.934 | 1.0809 | 0.2985 | 1.568 | 0.672 | 3.659 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.671 | 0.083 | 5.404 |
| exposure No exposure vs TNF At database=MPCD | 0.535 | 0.067 | 4.272 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.550 | 0.237 | 1.276 |
| exposure No exposure vs TNF At database=Marketscan | 1.699 | 0.946 | 3.052 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.528 | 0.738 | 3.164 |
| exposure No exposure vs TNF At database=Medicare | 1.699 | 0.869 | 3.321 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27268 | 421 | 26847 | 98.46 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 14444.437 | 14293.671 |
| AIC | 14444.437 | 14311.671 |
| SBC | 14444.437 | 14348.054 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 150.7667 | 9 | <.0001 |
| Score (Model-Based) | 144.9432 | 9 | <.0001 |
| Score (Sandwich) | 70.9546 | 9 | <.0001 |
| Wald (Model-Based) | 134.7296 | 9 | <.0001 |
| Wald (Sandwich) | 53.7271 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 3.0779 | 0.2146 |
| database | 2 | 3.3611 | 0.1863 |
| exposure*database | 4 | 7.0136 | 0.1352 |
| SEX | 1 | 1.5909 | 0.2072 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.48945 | 0.36197 | 2.529 | 1.8284 | 0.1763 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.58114 | 0.33182 | 3.355 | 3.0673 | 0.0799 | exposure No exposure | ||||
| database | MPCD | 1 | 0.20065 | 1.01417 | 6.829 | 0.0391 | 0.8432 | database MPCD | ||||
| database | Marketscan | 1 | -0.68159 | 0.41593 | 3.038 | 2.6854 | 0.1013 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.85704 | 1.16241 | 2.616 | 0.5436 | 0.4609 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -1.04801 | 0.55574 | 1.502 | 3.5561 | 0.0593 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -1.25228 | 1.01547 | 3.124 | 1.5208 | 0.2175 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.07927 | 0.43500 | 2.074 | 0.0332 | 0.8554 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | -0.28560 | 0.22643 | 3.007 | 1.5909 | 0.2072 | 0.752 | 0.482 | 1.171 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.692 | 0.089 | 5.406 |
| exposure No exposure vs TNF At database=MPCD | 0.511 | 0.071 | 3.687 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.572 | 0.247 | 1.325 |
| exposure No exposure vs TNF At database=Marketscan | 1.652 | 0.929 | 2.938 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.631 | 0.803 | 3.316 |
| exposure No exposure vs TNF At database=Medicare | 1.788 | 0.933 | 3.426 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27268 | 421 | 26847 | 98.46 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 14444.437 | 14307.894 |
| AIC | 14444.437 | 14325.894 |
| SBC | 14444.437 | 14362.278 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 136.5430 | 9 | <.0001 |
| Score (Model-Based) | 130.6260 | 9 | <.0001 |
| Score (Sandwich) | 70.2984 | 9 | <.0001 |
| Wald (Model-Based) | 120.4030 | 9 | <.0001 |
| Wald (Sandwich) | 53.6654 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.1894 | 0.3346 |
| database | 2 | 3.3350 | 0.1887 |
| exposure*database | 4 | 7.1993 | 0.1257 |
| indHospInf | 1 | 0.0104 | 0.9188 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.43827 | 0.35887 | 2.504 | 1.4915 | 0.2220 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.51902 | 0.35098 | 3.561 | 2.1868 | 0.1392 | exposure No exposure | ||||
| database | MPCD | 1 | 0.20877 | 1.02654 | 6.886 | 0.0414 | 0.8388 | database MPCD | ||||
| database | Marketscan | 1 | -0.68713 | 0.42180 | 3.071 | 2.6539 | 0.1033 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.83289 | 1.15437 | 2.596 | 0.5206 | 0.4706 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -1.02016 | 0.55531 | 1.498 | 3.3749 | 0.0662 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -1.21411 | 1.01051 | 3.108 | 1.4435 | 0.2296 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.01717 | 0.44797 | 2.139 | 0.0015 | 0.9694 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | -0.05055 | 0.49574 | 2.225 | 0.0104 | 0.9188 | 0.951 | 0.360 | 2.512 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.674 | 0.084 | 5.407 |
| exposure No exposure vs TNF At database=MPCD | 0.499 | 0.067 | 3.712 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.559 | 0.241 | 1.294 |
| exposure No exposure vs TNF At database=Marketscan | 1.652 | 0.929 | 2.938 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.550 | 0.767 | 3.132 |
| exposure No exposure vs TNF At database=Medicare | 1.680 | 0.845 | 3.343 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27268 | 421 | 26847 | 98.46 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 14444.437 | 14268.928 |
| AIC | 14444.437 | 14296.928 |
| SBC | 14444.437 | 14353.524 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 175.5097 | 14 | <.0001 |
| Score (Model-Based) | 170.8916 | 14 | <.0001 |
| Score (Sandwich) | 88.6524 | 14 | <.0001 |
| Wald (Model-Based) | 160.5576 | 14 | <.0001 |
| Wald (Sandwich) | 67.4340 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 3.0714 | 0.2153 |
| database | 2 | 3.3317 | 0.1890 |
| exposure*database | 4 | 7.1950 | 0.1259 |
| meanPredEqDoseCat | 4 | 3.8613 | 0.4251 |
| SEX | 1 | 1.9285 | 0.1649 |
| indHospInf | 1 | 0.0126 | 0.9108 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.48310 | 0.35737 | 2.485 | 1.8274 | 0.1764 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.58922 | 0.33641 | 3.373 | 3.0677 | 0.0799 | exposure No exposure | ||||
| database | MPCD | 1 | 0.18511 | 1.02929 | 6.900 | 0.0323 | 0.8573 | database MPCD | ||||
| database | Marketscan | 1 | -0.69658 | 0.42842 | 3.117 | 2.6436 | 0.1040 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.86391 | 1.16050 | 2.610 | 0.5542 | 0.4566 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -1.06012 | 0.55017 | 1.484 | 3.7130 | 0.0540 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -1.18755 | 1.05092 | 3.227 | 1.2769 | 0.2585 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -0.05811 | 0.44427 | 2.115 | 0.0171 | 0.8959 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.19527 | 0.78720 | 1.145 | 0.0615 | 0.8041 | 0.823 | 0.176 | 3.848 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.33523 | 0.29065 | 3.382 | 1.3303 | 0.2488 | 1.398 | 0.791 | 2.472 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.42800 | 0.42793 | 1.277 | 1.0003 | 0.3172 | 0.652 | 0.282 | 1.508 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.49459 | 0.42490 | 2.872 | 1.3550 | 0.2444 | 1.640 | 0.713 | 3.771 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | -0.31533 | 0.22707 | 3.006 | 1.9285 | 0.1649 | 0.730 | 0.467 | 1.139 | Administrative Sex F | |
| indHospInf | 1 | -0.05576 | 0.49773 | 2.230 | 0.0126 | 0.9108 | 0.946 | 0.357 | 2.509 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.683 | 0.087 | 5.374 |
| exposure No exposure vs TNF At database=MPCD | 0.550 | 0.071 | 4.232 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.562 | 0.242 | 1.306 |
| exposure No exposure vs TNF At database=Marketscan | 1.701 | 0.948 | 3.051 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.621 | 0.805 | 3.266 |
| exposure No exposure vs TNF At database=Medicare | 1.803 | 0.932 | 3.485 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27268 | 421 | 26847 | 98.46 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 1813.514 | 1798.421 |
| AIC | 1813.514 | 1822.421 |
| SBC | 1813.514 | 1870.932 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 15.0936 | 12 | 0.2364 |
| Score (Model-Based) | 15.5065 | 12 | 0.2149 |
| Score (Sandwich) | 52.1643 | 12 | <.0001 |
| Wald (Model-Based) | 14.6975 | 12 | 0.2584 |
| Wald (Sandwich) | 50.1377 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.6338 | 0.2680 |
| database | 2 | 2.1690 | 0.3381 |
| exposure*database | 4 | 8.5260 | 0.0741 |
| meanPredEqDoseCat | 4 | 4.9245 | 0.2951 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 0.66214 | 0.41767 | 0.694 | 2.5132 | 0.1129 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 0.25953 | 0.35029 | 0.879 | 0.5489 | 0.4588 | exposure No exposure | ||||
| database | MPCD | 1 | 0.24036 | 0.99758 | 3.572 | 0.0581 | 0.8096 | database MPCD | ||||
| database | Marketscan | 1 | -0.52600 | 0.45464 | 1.655 | 1.3386 | 0.2473 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | -0.74319 | 1.09482 | 0.998 | 0.4608 | 0.4972 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -1.05568 | 0.56439 | 0.625 | 3.4988 | 0.0614 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | -0.97634 | 0.99508 | 1.094 | 0.9627 | 0.3265 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.09674 | 0.44723 | 0.837 | 0.0468 | 0.8287 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -1.75034 | 0.88930 | 0.257 | 3.8739 | 0.0490 | 0.174 | 0.030 | 0.993 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.05523 | 0.42558 | 1.865 | 0.0168 | 0.8968 | 1.057 | 0.459 | 2.434 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | -0.29190 | 0.74378 | 0.880 | 0.1540 | 0.6947 | 0.747 | 0.174 | 3.209 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.22427 | 0.55985 | 1.343 | 0.1605 | 0.6887 | 1.251 | 0.418 | 3.749 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.922 | 0.147 | 5.793 |
| exposure No exposure vs TNF At database=MPCD | 0.488 | 0.062 | 3.877 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.675 | 0.280 | 1.627 |
| exposure No exposure vs TNF At database=Marketscan | 1.428 | 0.764 | 2.669 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 1.939 | 0.855 | 4.396 |
| exposure No exposure vs TNF At database=Medicare | 1.296 | 0.652 | 2.576 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27624 | 42 | 27582 | 99.85 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 1440.242 | 1402.822 |
| AIC | 1440.242 | 1418.822 |
| SBC | 1440.242 | 1432.724 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 37.4195 | 8 | <.0001 |
| Score (Model-Based) | 31.6445 | 8 | 0.0001 |
| Score (Sandwich) | 26.6983 | 8 | 0.0008 |
| Wald (Model-Based) | 20.5504 | 8 | 0.0084 |
| Wald (Sandwich) | 4365.9366 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.6450 | 0.2665 |
| database | 2 | 624.4461 | <.0001 |
| exposure*database | 4 | 220.8521 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 1.68799 | 1.05179 | 2.007 | 2.5756 | 0.1085 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.53647 | 0.98210 | 2.108 | 2.4476 | 0.1177 | exposure No exposure | ||||
| database | MPCD | 1 | -13.12045 | 1.00943 | 0.002 | 168.9438 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | 1.67870 | 1.20237 | 2.678 | 1.9493 | 0.1627 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 12.66406 | 1.46028 | 0.003 | 75.2095 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -2.73964 | 1.46117 | 1.748 | 3.5155 | 0.0608 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 12.27706 | 1.40534 | 0.002 | 76.3174 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -2.96106 | 1.41667 | 1.716 | 4.3687 | 0.0366 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1710079 | 231201.4 | 12648588 |
| exposure No exposure vs TNF At database=MPCD | 998021.2 | 136669.6 | 7287990 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.349 | 0.043 | 2.863 |
| exposure No exposure vs TNF At database=Marketscan | 0.241 | 0.036 | 1.587 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 5.409 | 0.688 | 42.498 |
| exposure No exposure vs TNF At database=Medicare | 4.648 | 0.678 | 31.860 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27624 | 42 | 27582 | 99.85 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 1440.242 | 1391.293 |
| AIC | 1440.242 | 1415.293 |
| SBC | 1440.242 | 1436.145 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 48.9490 | 12 | <.0001 |
| Score (Model-Based) | 49.4368 | 12 | <.0001 |
| Score (Sandwich) | 35.5092 | 12 | 0.0004 |
| Wald (Model-Based) | 35.0539 | 12 | 0.0005 |
| Wald (Sandwich) | 5817.3587 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.6773 | 0.2622 |
| database | 2 | 600.5789 | <.0001 |
| exposure*database | 4 | 204.4626 | <.0001 |
| meanPredEqDoseCat | 4 | 2354.9825 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 1.68116 | 1.06697 | 2.036 | 2.4826 | 0.1151 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.54434 | 0.95537 | 2.052 | 2.6130 | 0.1060 | exposure No exposure | ||||
| database | MPCD | 1 | -12.32022 | 0.93033 | 0.002 | 175.3721 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | 1.72917 | 1.16756 | 2.596 | 2.1934 | 0.1386 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 11.93367 | 1.43123 | 0.004 | 69.5232 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -2.71902 | 1.46489 | 1.752 | 3.4452 | 0.0634 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 11.48682 | 1.38644 | 0.004 | 68.6428 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -2.98319 | 1.42284 | 1.724 | 4.3959 | 0.0360 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -13.31160 | 0.39772 | 0.000 | 1120.2380 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.50698 | 0.54182 | 1.589 | 0.8755 | 0.3494 | 0.602 | 0.208 | 1.742 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 1.40301 | 1.02951 | 2.405 | 1.8572 | 0.1729 | 4.067 | 0.541 | 30.594 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.00389 | 0.68122 | 1.211 | 0.0000 | 0.9954 | 1.004 | 0.264 | 3.815 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 818179.1 | 111497.4 | 6003882 |
| exposure No exposure vs TNF At database=MPCD | 456412.8 | 62485.51 | 3333775 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.354 | 0.044 | 2.832 |
| exposure No exposure vs TNF At database=Marketscan | 0.237 | 0.034 | 1.637 |