Effectiveness of a computerized drug-monitoring program to detect and prevent adverse drug events and medication non-adherence in outpatient ambulatory care: study protocol of a randomized controlled trial
Clinical Epidemiology Program, Ottawa Hospital Research Institute, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada
The Ottawa Hospital, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada
Department of Epidemiology and Community Medicine and Department of Medicine University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
Institute for Clinical Evaluative Sciences – Ottawa (ICES@uOttawa), ASB-1, 1053 Carling Avenue, Ottawa, ON K1Y 4E9, Canada
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1020 Pine Avenue West, Montréal, QC H3A 1A2, Canada
Clinical and Health Informatics Research Group, McGill University, 1140 Pine Avenue West, Montréal, QC H3A 1A3, Canada
School of Rehabilitation, Université de Montréal, C.P. 6128, succursale Centre-ville, Montréal, QC H3C 3J7, Canada
Center for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), site Centre de Réadaptation Lucie-Bruneau, 2275 Avenue Laurier Est, Montréal, QC H2H 2N8, Canada
Department of Medicine, Royal Victoria Hospital, McGill University, 687 Pine Avenue West, Room A3.09, Montréal, QC H3A 1A1, Canada
Medications are an effective intervention for managing and preventing health problems but their benefit can be undermined by non-adherence or adverse drug events (ADEs). Since these issues may be interconnected, efforts to improve non-adherence should also include reduction of ADEs. We have developed the ISTOP-ADE system (Information Systems-enabled Outreach for Preventing Adverse Drug Events), which enables timely monitoring and managing of ADEs. The objectives of this study are to determine whether the ISTOP-ADE system, compared to routine care, will reduce: a) the probability of discontinuing the use of prognosis-altering medications; b) the probability of a patient experiencing a severe ADE; c) the proportion of patients experiencing ADEs, preventable ADEs and ameliorable ADEs; and d) health services utilization.
We will randomly assign 2,200 adult ambulatory patients in the province of Québec who have been prescribed an incident medication for the management or prevention of a chronic health condition, to routine care or the ISTOP-ADE system. The ISTOP-ADE system consists of an interactive voice response system (IVRS) paired with pharmacist support. The IVRS will call patients at 3 and 17 days post-prescription to determine if they are experiencing any problems and connect them with a pharmacist when required or desired by the patient. We will evaluate medication persistence at 180 days and health-care utilization using provincial administrative data. Two blinded physicians will ascertain ADE status through a case review.
We expect the ISTOP-ADE intervention to be feasible and to improve the quality of patient care through improved medication adherence, reduced ADE duration and reduced number of ADEs resulting in an emergency department or inpatient encounter. This in turn could lower health-care utilization, saving costs and lowering the burden on emergency departments and family practices. The success of ISTOP-ADE would present opportunities to implement this intervention through health systems, health insurance agents and commercial pharmacies.
ClinicalTrials.gov Identifier:
Medications are an effective intervention for managing and preventing many acute and chronic health-care problems. Their benefit is commonly reduced by non-adherence, in which patients either do not take or stop taking the medication as prescribed, or by adverse drug events (ADEs), in which patients experience side effects of the medications. These issues are interrelated. Some patients do not take their medication due to their fear of an impending ADE, while others stop taking the medication because of an ADE. Therefore, efforts to increase adherence should include efforts to target ADE reduction specifically.
To address these concerns, we have developed the Information Systems-enabled Outreach for Preventing ADEs (ISTOP-ADE) system (protocol version 1, 1 March 2012). The ISTOP-ADE system consists of a set of business processes supported by a technology infrastructure. The information technology is designed to connect providers to patients and includes an electronic health record system, a clinical data repository and an interactive voice response system (IVRS). This system enables timely monitoring of patients for ADEs and couples it with an effective arm to manage ADEs if, and when, they occur.
We recently established the feasibility and acceptability of the ISTOP-ADE system in a prospective cohort study. The pilot study included 628 patients who were prescribed an incident prescription. The ISTOP-ADE system successfully contacted 90% of patients. Important measures of the system’s effectiveness included the identification of 45% of ADEs, 50% of all potential ADEs and 30% of primary non-adherence episodes. In terms of potential benefits, it positively influenced the management of 42% of all medication-related problems. In terms of acceptability, almost all patients found it easy to use and understand and reported they would use the system again if it was provided to them. Physicians and pharmacists also supported the system 1 2 . While these results are favorable, a controlled clinical trial in which patients are randomly assigned to the ISTOP-ADE system or routine care is required to determine the system’s effectiveness. We therefore designed this study.
This study has been approved by the McGill Institutional Review Board (A01-B02-02A) and the Ottawa Health Science Network Research Ethics Board (20130285-01H).
This research will occur during ambulatory care in the province of Québec, Canada. We will study prescriptions in patients receiving primary care from a selected group of physicians using the Medical Office of the 21st Century (MOXXI) electronic health record system. MOXXI was developed by the McGill University’s Clinical and Health Informatics Research Group. It is currently used by over 100 primary care physicians in Montréal and Québec City. The MOXXI system is linked to the provincial insurance company, Régie de l’assurance maladie du Québec (RAMQ), resulting in an electronic medical record that displays a drug profile of prescribed as well as dispensed drugs, emergency department visits and hospitalizations in the past 12 months, a list of active and past health problems, and an electronic prescribing tool. Data stored by MOXXI have been used by the McGill research team for medical research in the past 3 4 .
The primary objective is to determine whether the ISTOP-ADE system, compared to routine care, will reduce the probability of discontinuing the use of prognosis-altering medications in patients prescribed an incident medication to manage or prevent a chronic health condition.
a. Determine whether the ISTOP-ADE system, compared to routine care, will reduce the probability of a patient experiencing a severe ADE (defined as an ADE lasting at least 7 days or causing an emergency department visit).
b. Determine whether the ISTOP-ADE system, compared to routine care, will reduce the proportion of patients experiencing ADEs, preventable ADEs and ameliorable ADEs.
c. Determine whether the ISTOP-ADE system, compared to routine care, will reduce health services utilization (comprising physician visits, emergency department encounters and hospitalizations) at 12 months following an incident prescription.
d. Measure the costs associated with the ISTOP-ADE system.
This study will include French- and English-speaking adult patients (age >18) who receive a high-risk incident prescription, use RAMQ insurance to pay for medications and are followed by a physician who has consented to be in the MOXXI research network. We will exclude patients if their physicians do not deem them appropriate for study inclusion.
We define high-risk prescriptions as medications commonly used to prevent progression or complications related to the following conditions: congestive heart failure, hypertension, dyslipidaemia, type 2 diabetes mellitus, coronary artery disease, cerebrovascular disease, atrial fibrillation, chronic renal failure, chronic obstructive lung disease, depression, dementia, autoimmune conditions, seizures, and chronic pain. The selected medications (Table 1) have an important impact on outcomes or they have been shown to have a high frequency of ADEs 5 6 . We will consider prescriptions as ‘incident’ if the patient had not received a prior prescription for that medication in the 12 months preceding the index event.
|
Disease entity |
Drug classes included |
|
Congestive heart failure |
Angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, hydralazine, mineralocorticoid (aldosterone) receptor antagonists, nitrate, diuretic, cardiac glycoside, β-adrenergic blocking agents |
|
Diabetes mellitus |
Sulfonylurea/insulin secretagogue, biguanide, A-glucosidase inhibitor thiazolidinedione, incretin therapy (dipeptidyl peptidase-4 inhibitor), insulin |
|
Hypertension |
β-adrenergic blocking agents, diuretic, calcium-channel blocking agents, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, nitrate, central α-agonists |
|
Coronary artery disease |
β-adrenergic blocking agents, statin, calcium-channel blocking agents, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, nitrate, acetylsalicylic acid, clopidogrel |
|
Dyslipidemia |
Statin, cholestyramine resin, fibric acid derivatives, niacin derivative, cholesterol absorption inhibitor |
|
Cerebrovascular disease |
Acetylsalicylic acid, clopidogrel, statin, dypiramidole |
|
Atrial fibrillation |
β-adrenergic blocking agents, cardiac glycoside, class III anti-arrhythmics, class Ic anti-arrhythmics, calcium-channel blocking agents, vitamin K antagonist, thrombin inhibitor, Acetylsalicylic acid |
|
Chronic kidney disease |
Angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, thiazide diuretic, β-adrenergic blocking agents, calcium-channel blocking agents |
|
Chronic obstructive pulmonary disease |
Short-acting bronchodilators, long-acting bronchodilators, phosphodiesterase type-4 inhibitors, combination inhaled corticosteroids and long-acting bronchodilators, theophylline |
|
Depression |
Serotonin-specific reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, quetiapine, bupropion, trazodone, mirtazapine |
|
Dementia |
Parasympathomimetic (cholinergic) |
|
Autoimmune conditions |
Corticosteroids |
|
Seizures, chronic pain |
Anticonvulsants |
When a physician uses MOXXI to prescribe a new medication for a patient, a pop-up window will appear on their computer screen to indicate the patient’s eligibility. This pop-up window will prompt the doctor to inform the patient of the study, confirm their eligibility and seek consent. We will obtain informed consent from each participant. If the patient consents, the physician will confirm the patient’s phone number, preferred language and preferred time of day to be called. If the physician deems the patient ineligible or the patient does not consent, then the reason will be captured in MOXXI using a standard classification.
The unit of analysis for the study is the individual patient, each of whom we will randomly assign to the intervention or control arms using a computer algorithm. We will perform stratified randomization at the physician practice level with block sizes of four. We will only randomize patients once a physician confirms the patient’s eligibility for enrolment. We will update the ISTOP-ADE system with the patient’s treatment group but this information will not be available to the prescribing physician or the patient.
The intervention consists of an IVRS call coupled with pharmacist support. We will program the IVRS to call patients automatically on day 3 and day 17 following their prescription. If a call is not answered, the system will make as many as eight separate attempts (two per day over a maximum of 4 days) before marking the call as unsuccessful. If a call is answered, the IVRS will proceed through a calling algorithm. The following questions will be asked at each call:
1. Since receiving your medication, have you started taking it?
2. Since receiving your medication, have you had any problems?
3. Since receiving your medication, have you developed any new symptoms?
4. Would you like to speak to a pharmacist?
If the patient answers ‘No’ to the first question or ‘Yes’ to any of the three remaining questions, the IVRS will inform the patient that a pharmacist will personally contact them within 2 business days. The IVRS will send an email to a pharmacist informing them of the patient’s request. In addition, the IVRS will be capable of receiving inbound calls from patients regarding their medications at any time. This will also connect the patient to the pharmacist according to the same business rules as for the outbound IVRS calls.
When required, the pharmacist will contact the patient. Prior to contact, the pharmacist will access the electronic health record to obtain background information on the patient’s health status and medication use. During the call, the pharmacist will document the patient’s problems as well as their recommendation for resolving the problem in the electronic health record. If the pharmacist deems the patient’s problems are significant, then the pharmacist can escalate the issue to the patient’s primary care physician using the electronic health record.
The control arm consists of routine care.
We will perform a standard interview of patients at 21 days to determine the development of new symptoms, medication use and health services use since their prescription. The study personnel performing the interview will not have access to knowledge regarding the study group to which the patient is allocated.
We will link the study database to the drug benefit and hospital record files contained at RAMQ using the patient’s provincial health insurance number.
We define persistence as ‘having a continuous supply of at least one medication used to treat the index condition, with gaps no greater than 90 days, in the first 6 months of treatment’. We will use validated methods to measure medication persistence using administrative claims data on prescription refills 7 8 9 10 11 . Prescription refills provide a good proxy measure of medication use because refill rates are strongly correlated with targeted clinical outcomes such as blood pressure 7 . We will construct medication dispensing histories for all patients and medications during the study follow-up period using the RAMQ medication file.
We will use previously developed methods to ascertain ADE status 12 13 14 15 16 17 . Specifically, a clinician will create a case summary describing the post-prescription course for each patient experiencing a problem. Problems will be identified during the 21-day interview. The clinician will compile information derived from the post-intervention interview and a review of the patient’s MOXXI record using a standardized format. The summary will elaborate on the patient’s underlying health conditions, the medications currently being used (including the index prescription), the timing of the problem, the management of the problem, the timing of the resolution and what the patient was told about the cause of the problem.
To define ADE status, two physicians (blinded to allocation group) will review each case summary and determine whether the case represents an ADE. This determination is made using a six-point classification system with a cut-point of 3. A case is considered to be an ADE if both reviewers agree that the case was an undesirable outcome and that outcome was more likely caused by medication use than the patient’s underlying health condition. This method has been widely adopted as the standard approach for ADE classification in patient safety research 12 13 14 15 16 17 . For an ADE, the reviewers will further classify its duration, preventability, amelioration and severity using standard definitions 12 13 14 15 16 17 18 19 .
Standard methods to measure health services use using provincial claims data will be used. All physician visits, emergency department visits, hospitalizations and medication claims during the 12 months following index prescription will be identified using the RAMQ data through MOXXI.
We will record the entire amount of time the study pharmacist spends supporting patients in the intervention group. This will allow us to calculate costs at the patient level as well as aggregated at the population level. We will also track implementation and support costs for the IVRS, including calling charges. These costs will be prorated across the study population.
To determine factors that influence outcomes, we will use data in the MOXXI system to derive baseline information on patients, including demographic information (age, gender, language of choice and location of residence), active and past medical diagnoses and medication use in the preceding year (number of new drug starts and adherence).
Due to the nature of the study, blinding of patients and health-care providers will not be possible. However, we will blind personnel performing the interviews and physicians performing the assessment of ADE status of study group allocation.
We have based our sample size on the following assumptions:
a. A baseline probability of non-persistence of 25% (based on a prior research study evaluating persistence with anti-hypertensive therapy using the same methods we will for this study) 11
b. A minimally clinical important difference of 20%
c. A 10% loss to follow-up (based on our pilot study)
d. An enrollment rate of 50% (based on our pilot study)
e. Other specifications: α = 0.05, β = 0.20 and two-sided tests for significance will be used
Given these assumptions, we will need to approach 4,708 patients in total (2,354 patients in each treatment arm being eligible and approached for enrollment). This will result in 2,354 patients being enrolled (1,177 patients in each arm) and 2,118 patients evaluated for the composite outcome (1,059 patients in each arm). To be more conservative, we will enroll 1,100 patients in each arm.
Data will be exported from the MOXXI system and analyzed using SAS software (Cary, NC, USA). All data analysis will be performed in secure physical locations using hardware that is password protected. Only study personnel will have access to the data. Simple descriptive statistics to describe the patient population, call statistics and outcome measures will be used. Continuous variables will be described using median and inter-quartile ranges, while categorical variables will be described using frequency distributions. The statistical significance of any associations between group assignment and measures will be assessed using the Wilcoxon rank sum test and or the chi-square test, respectively, for continuous and categorical variables. Since the primary outcome is binary, tests to compare outcomes between the intervention and control groups will be simple chi-square statistics. An alpha of 0.05 as a threshold to determine statistical significance using a two-tailed distribution will be applied.
As a sensitivity analysis, logistic regression modeling will be used to assess possible baseline factors that are associated with the outcome and differ between the intervention and control groups. Analogous analyses to assess significance for the individual components of the composite primary outcome and the binary secondary outcome variables will also be performed (ADE occurrence, preventable ADE occurrence and ameliorable ADE occurrence).
To compare health services utilization, since the outcomes are event data, which follow a Poisson distribution, incidence rates for the outcome will be calculated. Incidence rates will be calculated using PROC GENMOD to create a t-test. Multivariable Poisson regression will be used to compare the rates, while adjusting for baseline factors. The model will use the treatment group as an independent covariate. If over-dispersion is noted, a negative binomial model will be used.
The physicians and their patients enrolled in the MOXXI program are covered under an umbrella consent program, which is approved and monitored by McGill’s Institutional Review Board. In addition, patients will be given opportunities to become informed about the project and to withdraw, as appropriately defined under the Tri-Council’s guidelines.
The entire ISTOP-ADE study will take 5 years from start to finish. Patient enrolment will run for 3 years to ensure sample size requirements are met. Patient follow-up will continue for 1 year from enrolment. Case summaries and physician reviews, as well as data validation and quality checks will occur throughout the lifespan of the study. We have budgeted 12 months to accomplish the analysis and knowledge translation activities.
We have planned this randomized trial to assess the effectiveness and cost-effectiveness of an automated outreach program to monitor patients receiving a new ambulatory care prescription. It is an important study as the intervention has shown promising results in a pilot study. Some health payers and pharmacies may feel that this intervention is already warranted on face value and based on our preliminary findings. We have advised against this approach as the system has not been compared against routine care. In a situation where there are limited resources, it is not appropriate to invest in interventions of unknown effectiveness.
We chose adherence with prognosis-altering medications as our primary outcome. This outcome is important as many studies have demonstrated poor adherence – approximately 50% of patients with chronic illness do not take their medication as prescribed – and this in turn has been estimated to have major impacts on disease progression and health-care costs 20 21 . We will assess this outcome using administrative data. This ascertainment method has been demonstrated to be accurate and will not be biased by an inability to blind patients to the intervention. Our secondary outcomes are similarly important. In particular, ADEs are common following incident prescriptions 15 16 . While many of the symptoms related to ADEs are short in duration, a substantial proportion of patients have symptoms lasting longer than 7 days and can lead patients to discontinue their medications on their own. Collectively, these outcomes will allow us to assess adequately the value of our intervention to patients and the health-care system.
Our study will also give us an opportunity to assess further implementation issues. We will track the costs of the intervention closely, including the workload required by our pharmacist to follow up the automated calls and by the physicians, who may need to do extra work to respond to patient complaints. We will also assess the failed automated calls to assess which patients do not accept this type of intervention. Finally, we will conduct an assessment of patient factors associated with adherence. All of this information will guide decisions pertaining to whether and how this system should be implemented, and to whom it should be directed.
This is an ambitious study, which will run in over 100 primary care practices in two large urban settings. It will take 3 years to complete the recruitment and follow-up. We are randomizing patients at the patient rather than provider level because there is little risk of contamination or co-intervention. The patients are unlikely to interact with each other, and, based on our pilot study, there was very little interaction between patients and doctors within the 3 weeks of their prescription. There are some sources of bias in our design to be considered. The primary risk is the lack of blinding in patients and primary care doctors. This is a concern as knowledge of allocation could change behavior. However, based on findings from our pilot study, we predict this is unlikely. In addition, outcome assessment is done objectively or by blinded reviewers. In short, this study will have internal validity and will be generalizable.
In summary, we have previously developed an automated outreach program for patients prescribed new medications. We have tested this intervention in a pilot study. This work found the intervention to be feasible and suggested it might improve the quality of patient care through reduced ADE duration and improved medication adherence. We have designed this randomized trial to test whether the intervention is effective compared to routine care. If the ISTOP-ADE system were demonstrated to be effective, then there would be significant opportunities to implement this intervention through health systems, health insurance agents and commercial pharmacies.
The ISTOP-ADE study is anticipated to start early 2015.
ADE: adverse drug event; ISTOP-ADE: Information Systems-enabled Outreach for Preventing ADEs; IVRS: interactive voice response system; MOXXI: Medical Office of the 21st Century; RAMQ: Régie de l’assurance maladie du Québec.
The authors declare that they have no competing interests.
AF, RT, CA, DB and CVW conceived the study and participated in its design and oversight. AF, AJ and TEE participated in writing the manuscript. All authors read and approved the final version of the manuscript.
The ISTOP-ADE study is receiving funding from the Canadian Institutes of Health Research (ResearchNet ID: 159794).
Usability of a computerised drug monitoring programme to detect adverse drug events and non-compliance in outpatient ambulatory care
Using information technology to improve the monitoring of outpatient prescribing
A randomized trial of the effectiveness of on-demand versus computer-triggered drug decision support in primary care
Detection of adverse drug events and other treatment outcomes using an electronic prescribing system
Trouble getting started: predictors of primary medication nonadherence
Primary medication non-adherence: analysis of 195,930 electronic prescriptions
Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy
Estimating medication persistency using administrative claims data
A general method of compliance assessment using centralized pharmacy records. Description and validation
The assessment of refill compliance using pharmacy records: methods, validity, and applications
Influence of physicians’ management and communication ability on patients’ persistence with antihypertensive medication
Incidence and preventability of adverse drug events in hospitalized adults
Ottawa Hospital Patient Safety Study: incidence and timing of adverse events in patients admitted to a Canadian teaching hospital
Adverse drug events occurring following hospital discharge
Adverse drug events in ambulatory care
Incidence and preventability of adverse drug events among older persons in the ambulatory setting
The critical care safety study: the incidence and nature of adverse events and serious medical errors in intensive care
Clarification of terminology in drug safety
Adverse drug reactions: definitions, diagnosis, and management
Interventions for enhancing medication adherence
Meta-analysis of trials of interventions to improve medication adherence


Each of them could be used independently, or together where they release all their potential.
Really useful and unobstrusive, they could be used anywhere for any kind of project.
To install last version of deepjs core :
or
To get a fully workable example on how it's loaded in a web page :
More info soon.
Based on deepjs core, four perfectly isomorphic libraries, where each could also be used
independently or together, has been developped to form a powerful modern web app framework.
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{% extends "base.html" %} {% block content %}
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|---|---|---|---|---|---|---|
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I am now a graduate student at the University of Houston.
I do research on wireless measurement and distributed systems.


TimeChecker-Web
click EXEC first, then DONE.
TimeChecker-Web will show duration time.
exec
done
clear console


---
layout: page
tags: [Jekyll, HADDOCK, Bonvin, Docking, Simulation, Molecular Dynamics, Structural Biology, Computational Biology, Modelling, Protein Structure]
modified: 2014-08-08T20:53:07.573882-04:00
comments: false
image:
feature: pages/banner_software.jpg
---
HADDOCK2.2
HADDOCK-related publications
This page lists haddock development articles.
The original JACS paper, together with an introduction to the study of biomolecular complexes and an application to the UbcH5-CNOT4 complex can be found online in Cyril Dominguez's Ph.D. thesis:
When using HADDOCK cite:
And, if used, cite depending on the type of data and setting used the following publications:
The use of residual dipolar couplings in HADDOCK is described in:
The use of diffusion anisotropy data in HADDOCK is described in:
The use of pseudo contact shift restraints in HADDOCK is described in:
The use of SAXS data to score HADDOCK models is described in:
The quantitative use of chemical shifts to score HADDOCK models is described in:
Protein-peptide docking with HADDOCK is described in:
Solvated protein-protein docking using HADDOCK is described in:
Solvated protein-protein docking with Kyte-Doolittle propensities using HADDOCK is described in:
Solvated protein-DNA docking using HADDOCK is described in:
Flexible protein-DNA docking using HADDOCK is described in:
(Flexible) multibody docking using HADDOCK is described in:
Our results in CAPRI, the blind docking experiment,
are described in (Note that entire issues of Protein are dedicated to CAPRI):
- J.P.G.L.M. Rodrigues, A.S.J. Melquiond, E. Karaca, M. Trellet, M. Van Dijk, G.C.P. Van Zundert, C. Schmitz, S.J. de Vries, A. Bordogna, L. Bonati, P.L. Kastritis and A.M.J.J. Bonvin
"Defining the limits of homology modelling in information-driven protein docking"
Proteins: Struc. Funct. & Bioinformatics, 81, 2119-2128 (2013).
- S.J. de Vries, A.S.J. Melquiond, P.L. Kastritis, E. Karaca, A. Bordogna, M. van Dijk, J.P.G.L.M. Rodrigues and A.M.J.J. Bonvin
"Strengths and weaknesses of data-driven docking in CAPRI"
Proteins: Struc. Funct. & Bioinformatic, 78, 3242-3249 (2010).
- S.J. de Vries, A.D.J. van Dijk, M. Krzeminski, M. van Dijk, A. Thureau, V. Hsu, T. Wassenaar and A. M. J. J. Bonvin
"HADDOCK versus HADDOCK: New features and performance of HADDOCK2.0 on the CAPRI targets."
Proteins: Struc. Funct. & Bioinformatic, advanced online publication (2007).
- A.D.J. van Dijk, S.J. de Vries, C. Dominguez, H. Chen, H.-X. Zhou and A
.M.J.J. Bonvin
"Data-driven docking: HADDOCKs adventures in CAPRI."
Proteins: Struc. Funct. & Bioinformatics, 60, 232-238 (2005).
Reviews on data-driven docking:
- J.P.G.L.M Rodrigues and A.M.J.J. Bonvin
"Integrative computational modeling of protein interactions."
FEBS J., 281, 1988-2003 (2014).
- H. van Ingen and A.M.J.J. Bonvin
"Information-driven modeling of large macromolecular assemblies using NMR data."
J. Magn. Reson. 241, 103-114 (2014).
- E. Karaca and A.M.J.J. Bonvin
"Advances in integrated modelling of biomolecular complexes."
Methods, 59, 372-381 (2013).
- P.L. Kastritis and A.M.J.J. Bonvin
"Predicting and Dissecting High-order Molecular Complexity by Information-driven Biomolecular Docking"
In: Antimicrobial Drug Discovery. Emerging Strategies Adv. Mol. Cell. Microbiol., Eds G. Tegos and E. Mylokanis, CABI, 22, 232-246 (2012).
- A.S.J. Melquiond, E. Karaca, P.L. Kastritis and A.M.J.J. Bonvin
"Next challenges in protein-protein docking: From proteome to interactome and beyond."
WIREs Computational Molecular Science, 2, 642-651 (2012).
- Aalt D.J. van Dijk, Rolf Boelens and Alexandre M.J.J. Bonvin (2005).
"Data-driven docking for the study
of biomolecular complexes."
FEBS Journal, 272, 293-312.


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image: https://source.unsplash.com/j5LSbCqB1wA/2000x1322?a=.png
bottom_image: https://unsplash.it/2000/1322?a=.png
---
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pragma solidity 0.4.26;
import './interfaces/ISmartTokenController.sol';
import './interfaces/ISmartToken.sol';
import '../utility/TokenHolder.sol';
/**
* @dev The smart token controller is an upgradable part of the smart token that allows
* more functionality as well as fixes for bugs/exploits.
* Once it accepts ownership of the token, it becomes the token's sole controller
* that can execute any of its functions.
*
* To upgrade the controller, ownership must be transferred to a new controller, along with
* any relevant data.
*
* The smart token must be set on construction and cannot be changed afterwards.
* Wrappers are provided (as opposed to a single 'execute' function) for each of the token's functions, for easier access.
*
* Note that the controller can transfer token ownership to a new controller that
* doesn't allow executing any function on the token, for a trustless solution.
* Doing that will also remove the owner's ability to upgrade the controller.
*/
contract SmartTokenController is ISmartTokenController, TokenHolder {
ISmartToken public token; // Smart Token contract
address public bancorX; // BancorX contract
/**
* @dev initializes a new SmartTokenController instance
*
* @param _token smart token governed by the controller
*/
constructor(ISmartToken _token)
public
validAddress(_token)
{
token = _token;
}
// ensures that the controller is the token's owner
modifier active() {
require(token.owner() == address(this));
_;
}
// ensures that the controller is not the token's owner
modifier inactive() {
require(token.owner() != address(this));
_;
}
/**
* @dev allows transferring the token ownership
* the new owner needs to accept the transfer
* can only be called by the contract owner
*
* @param _newOwner new token owner
*/
function transferTokenOwnership(address _newOwner) public ownerOnly {
token.transferOwnership(_newOwner);
}
/**
* @dev used by a new owner to accept a token ownership transfer
* can only be called by the contract owner
*/
function acceptTokenOwnership() public ownerOnly {
token.acceptOwnership();
}
/**
* @dev withdraws tokens held by the controller and sends them to an account
* can only be called by the owner
*
* @param _token ERC20 token contract address
* @param _to account to receive the new amount
* @param _amount amount to withdraw
*/
function withdrawFromToken(IERC20Token _token, address _to, uint256 _amount) public ownerOnly {
ITokenHolder(token).withdrawTokens(_token, _to, _amount);
}
/**
* @dev allows the associated BancorX contract to claim tokens from any address (so that users
* dont have to first give allowance when calling BancorX)
*
* @param _from address to claim the tokens from
* @param _amount the amount of tokens to claim
*/
function claimTokens(address _from, uint256 _amount) public {
// only the associated BancorX contract may call this method
require(msg.sender == bancorX);
// destroy the tokens belonging to _from, and issue the same amount to bancorX
token.destroy(_from, _amount);
token.issue(msg.sender, _amount);
}
/**
* @dev allows the owner to set the associated BancorX contract
* @param _bancorX BancorX contract
*/
function setBancorX(address _bancorX) public ownerOnly {
bancorX = _bancorX;
}
}
|


Code Samples - Servlets
by Omkar Patil<EMAIL_ADDRESS>Register
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[Note: A request will not be processed further (or handed over to the Servlet), if the selected country in the drop down list is NOT India.]
<- Go back to the Home page


{{#each restaurant}}
{{name}}
{{location}}
Check Us Out On Yelp!
Owners: {{#each ownedBy}}
{{[]}}
{{/each}} {{#if acceptsApplePay}}
{{else}}
No Apple Pay
{{/if}} {{/each}}


[gecode-users] Gecode and Gist on Mac OS 10.6 "Snow Leopard"
Gustavo Gutierrez
gutierrez.gustavo at uclouvain.be
Fri Sep 4 14:20:55 CEST 2009
On 04 Sep 2009, at 13:50, Guido Tack wrote:
> Hi everyone,
>
> I've just upgraded my Mac to Snow Leopard and XCode 3.2 and ran a few
> quick checks. It seems everything works well. Here's a couple of
> notes:
>
> The installer package from the Gecode download page apparently works
> out of the box.
>
> It seems that the installer package for Qt 4.5 has some issues on Snow
> Leopard. As noted on
> http://labs.trolltech.com/blogs/2009/08/31/qt-46-on-mac-os-106/
> it may be necessary to uncheck the installation of Qt documentation.
>
> If you build Gecode yourself, you have to know that XCode 3.2 uses gcc
> 4.2.1 by default. You therefore don't have to configure with
> CC=gcc-4.2 CXX=g++-4.2 any longer. The new gcc is configured to
> produce 64 bit code by default. This is fine unless you want to
> compile Gist against the Qt binary package, which is 32 bit only. In
> this case, simply configure with --with-architectures=i386.
>
> If you encounter any other issues, let me know!
>
Apart from what you mentioned, the only thing I notice is that with
some trees in gist, some horizontal and vertical lines are drawn
around some nodes. This is randomly or at least I could not identify a
more deterministic pattern, probably it has something related to qt
and not to gecode.
Everything else seems to work fine, at least for me. I don't use the
binary installer, tough.
Regards,
Gustavo
More information about the gecode-users
mailing list


--- layout: default title: MONUMENTHOUSE language: python --- MONUMENT Intro Photos Events Breathe Deep Who We Are Monument is a new group for creative people of all stripes: artistic, scientific, and academic. Our headquarters in San Francisco is a workspace, a gallery, an event space, a residence, and a place to meet friends new and old.
Monument is a new group for creative people of all stripes: artistic, scientific, and academic.
Our headquarters in San Francisco is a workspace, a gallery, an event space, a residence, and a place to meet friends new and old.


Define, visualize a hull and calculate its hydrostatic properties.
A Ship object in the Vessel.js library is created from a specification object. The specification below defines a prismatic hull, without any additional part. The hull lines (stored in the halfBreadths property) are taken as symmetrical and are defined proportionally to the ship's main dimensions (stored in the attributes property):
Then, we create a Ship object from this specification:
The visualization is created with an interface built to transform the Ship object above in a Three.js render (see here for more details). The result is displayed below. The different colors indicate the position of the design draft.
To calculate the hydrostatic properties of the hull for a given draft, say, 2 m, the following method can be evoked:
Which returns:


I am running emons v7 on my home web server. I have information being posted to it from a node that is keeping track of temperatures at different locations on my property.
To make it easier for me to view at a glance I created a simple webpage that has the feed I want to view and the feed is set to public.
These are the lines I am using to display the feed data. Below that is the webpage code I am using. It works about 70% of the time. When it doesn't work the feeds will show 0 even though in my emon account they show the temperatures.

<link href="http://<IP_ADDRESS>/emonscms/Lib/bootstrap/css/bootstrap.css" rel="stylesheet">
<link href="http://<IP_ADDRESS>/emonscms/Lib/bootstrap/css/bootstrap-responsive.css" rel="stylesheet">
<title>Mike's Dash</title>

<link href="http://<IP_ADDRESS>/emonscms/Modules/dashboard/Views/js/widget.css" rel="stylesheet">

Temp of pool:

******************** Code out ****************


Programming Dashboard
For this project, I worked with the Webmaster of WREK Atlanta to create a dashboard for our Programming Director. Using Photoshop, Bootstrap, d3.js, and nvd3, we were able to give the Program Director more insight into when people tune in. Finding out the audience of a radio station can be quite expensive, so this was our solution. By combining data from WREK's caller logs, online listeners, and page views we were able to get a better idea of WREK's audience.
It can be viewed
here.


--- title: Request a Feature heading: Request a Feature description: Let us know what feature you would like to see us build next! ---
ryan@base11studios.com


DROP FUNCTION
Section: SQL Commands (7)Updated: 2012-08-14
Index Return to Main Contents
NAME
DROP FUNCTION - remove a functionSYNOPSIS
DROP FUNCTION [ IF EXISTS ] name ( [ [ argmode ] [ argname ] argtype [, ...] ] ) [ CASCADE | RESTRICT ]
DESCRIPTION
DROP FUNCTION removes the definition of an existing function. To execute this command the user must be the owner of the function. The argument types to the function must be specified, since several different functions can exist with the same name and different argument lists.
PARAMETERS
- IF EXISTS
- Do not throw an error if the function does not exist. A notice is issued in this case.
- name
- The name (optionally schema-qualified) of an existing function.
- argmode
- The mode of an argument: IN, OUT, INOUT, or VARIADIC. If omitted, the default is IN. Note that DROP FUNCTION does not actually pay any attention to OUT arguments, since only the input arguments are needed to determine the function's identity. So it is sufficient to list the IN, INOUT, and VARIADIC arguments.
- argname
- The name of an argument. Note that DROP FUNCTION does not actually pay any attention to argument names, since only the argument data types are needed to determine the function's identity.
- argtype
- The data type(s) of the function's arguments (optionally schema-qualified), if any.
- CASCADE
- Automatically drop objects that depend on the function (such as operators or triggers).
- RESTRICT
- Refuse to drop the function if any objects depend on it. This is the default.
EXAMPLES
This command removes the square root function:
DROP FUNCTION sqrt(integer);
COMPATIBILITY
A DROP FUNCTION statement is defined in the SQL standard, but it is not compatible with this command.
SEE ALSO
CREATE FUNCTION [create_function(7)], ALTER FUNCTION [alter_function(7)]
Index
This document was created by man2html, using the manual pages.
Time: 05:34:14 GMT, December 24, 2015


The OptionsList component can take a list of options from a data source. For this purpose, the optionsContainer attribute is used.
OptionsList
optionsContainer


Definition list Apple Pomaceous fruit of plants of the genus Malus in the family Rosaceae. Orange Nested The fruit of an evergreen tree of the genus Citrus. para Break Apple Pomaceous fruit of plants of the genus Malus in the family Rosaceae. Orange Nested The fruit of an evergreen tree of the genus Citrus. para Apple Pomaceous fruit of plants of the genus Malus in the family Rosaceae. Orange Nested The fruit of an evergreen tree of the genus Citrus. para


{{define "where"}}
Last Updated:
Anonymously: create a `.somewhere` file in your home dir with touch ~/.somewhere
Publicly: create a `.here` file in your home dir with touch ~/.here
Every 15 minutes this program runs `who --ips` and then looks up IP geo info on opted-in, logged in users. It hits Google's geocode API with the "[Region], [Country]" data it found to get general coordinates, and generates this data, stripping out usernames for anonymous users. When viewing the map, an AJAJ request is made to get the data and the points are added to the map.
You can see for yourself in the GitHub project, where contributions are welcome!
{{end}}


ATOM Navigator Options
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FILM TITLE: SUNDAY'S CHILDREN DIRECTOR: DANIEL BERGMAN COUNTRY: SWEDEN 1992 CINEMATOGRAPHY: TONY FORSBERG CAST: Thommy Berggren, Lena Enlhe, Henrik Linnros SUPER FEATURES: Excellent Film about Ingmar Bergman's life.
!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
The sad thing about this film, for Americans, is that it is slow. It is a film, like Daniel's father Ingmar, that is given to detail, and the minute nuances that are still taught at many acting schools. It is an outstanding film, probably a bit more "open" than the father's pictures, which tend to be mired in the emotional upheaval of the characters. Unlike his father, Daniel stands back, and allows them to look sheepish, and at times selfish, until the realization hits them, that while they meant well, they did not do very well.
This is a story, written by Ingmar Bergman himself, about his own growing up in a religious family, whose motives were not questioned, and whose desires were very idealistic. Pu, has an admiration for his father, but it isn't very clear weather it is because of the rather stern exterior and belief system, or if it is because the father is right. The father is not always right, and as Pu gets older, and now famous, facing his father, the elder Bergman is having problems coming to grips with his own idealism. Ingmar (Pu), has been expressing all of his idealism on film and studying it. The father has taken it all in, and is now suffering some terrible delusions, most of them from feeling like he failed as a father, since the mother asked for a divorce and left.
The great thing about this, is to watch, in the end, Ingmar's own stern conduct, in dealing with his father, just when he has reached a level of fame in the world cinema. The father has not succeeded, or if he did he does not feel this way. And Ingmar is not interested in wallowing in the garbage, as is not Daniel, in doing this film. It is a bit brutal, in many ways, but it does force a sort of therapy on the old man, that is working, however slowly.
Daniel Bergman is showing that he is also a fabulous director, like his own dad, whose legacy is without question one of the great accomplishments in the history of film. Daniel, unlike his father, has the ability of allowing the camera to move a little more than his own father, thus making the film a little more bearable for an audience that is used to fast paced films... but it is STILL painfully slow, and difficult to appreciate, unless we make a commitment to do so.
Like Sven Nykvist, with Ingmar so many times, Tony Forsberg comes off as a visual dynamo that makes this film alive. It is visually striking, and colorful. It helps the film live. With Sven's "quiet" camera, this film would have been exactly like the father's material ... stoic, but effective.
With excellent acting, and a very well written script, covering some thirty to forty years, this film can only signify that the younger Bergman is on the way to try and outdo his own father. And it helps to have the father provide a script of his own experience to help lead the way... similar to the story, isn't it...???
I suppose that the funny thing was to see an actor playing the older Bergman confronting his own father in 1968.... I think it would have been a bit "selfish" not to, but it would have added another dimension to the film..... the Bergman's of today are involved in a religious offering called film.... the Bergman's of yesterday were involved in the good book.... and there is a difference in the end... you must see the film to catch it.
4 1/2 of 5 GIBLOONS
The review above was posted to the
rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).
The Internet Movie Database accepts no responsibility for the contents of the
review and has no editorial control. Unless stated otherwise, the copyright
belongs to the author.
Please direct comments/criticisms of the review to relevant newsgroups.
Broken URLs inthe reviews are the responsibility of the author.
The formatting of the review is likely to differ from the original due
to ASCII to HTML conversion.
Related links: index of all rec.arts.movies.reviews reviews


| DOSE: |
1 cap |
oral |
GHB |
(liquid) |
| |
5 joints/cigs |
smoked |
Cannabis |
(plant material) |
The first time I had ever heard of GHB was on a trip to Huntsville with my friends and at that time I was just big into marijuana and shit like that.   We were riding around after church one night and he had a bottle of it and was selling a cap for 5 bucks and it was cheap so I decided to do it. Well just before then me and my friends had decided to buy a 20 bag of pot to smoke that night to.
  I felt damn good and sorta was looking to fight someone. We got to the dealer and got the pot and more people showed up and bought some and we all decided to match blunts and we all rolled some about 5 or so and we started smoking which I got completely blowed off this shit cause it was some fire.    I felt great for about an hour.
 I had had tacos that night and it was tearing into my stomach. I told my friends to pull over so I could get out but I just started puking all over my friend's car. I finally made it outside and puked about 3 minutes. That made me start tripping.
My Trip
We went to go smoke some pot after I puked and stopped at this boat dock. I didn't know where we were and thought we were parked on 12 feet of snow. I was tripping out hard. I thought I saw a guy talking to me for about an hour while they smoked the pot. My friends said I was talking to noone for a long time and kept saying that we were going to fall through the snow. There was no snow on the ground it was just white pavement. About that time my eyes started REM (Rapid Eye Movement). I couldn't focus on anything and I was freaking out. My friends didn't know what to do. I got home about 2 hours later and went to sleep.
My Experience all in all
I liked the feeling I got off of it and would definitely recommend it. I did it about 3 days after that and had no problem comboing with marijuana. I had a definite good experience then. The last time I did it was about a week ago and I smoked alot of pot and did a capful and drunk about half of case of beer and have never felt that great.
Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid.


{% extends theme("user/settings_layout.html") %} {% block settings_content %} {% from theme("macros.html") import render_field, horizontal_field , horizontal_select_field%}


Home
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{% if message %}
Importing {{ message }} articles. Head to the home page and refresh wildly to see the results.
{% else %}
This operation runs automatically. Calling it now might take some time. Are you sure?
Also, there isn't any ajax set up yet, so you'll have to check the celery logs to see when it's done loading.
{% endif %}


Emperor Shunaiman:
Do not lose those things. Without them you cannot complete your task, and the Empire will fall.
Do not fail us!


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Defines syntactic sugar for creating C# like properties. Specifically, I want to be able to do things like this: Vector3 v; Vector3 q = v.zyx; where 'zyx' is a getter that performs swizzling. I don't want to just expose a public member since that would require storing all the permutations of v.xyz.
Ideas in this code were borrowed from stack overflow: https://stackoverflow.com/questions/4225087/c-like-properties-in-native-c


| For immediate release |
|
The Federal Open Market Committee decided today to leave its target for the federal funds rate unchanged. Strengthening productivity growth has been fostering favorable trends in unit costs and prices, and much recent information suggests that these trends have been sustained. Nonetheless, the growth of demand has continued to outpace that of supply, as evidenced by a decreasing pool of available workers willing to take jobs. In these circumstances, the Federal Open Market Committee will need to be especially alert in the months ahead to the potential for costs to increase significantly in excess of productivity in a manner that could contribute to inflation pressures and undermine the impressive performance of the economy. Against this background, the Committee adopted a directive that was biased toward a possible firming of policy going forward. Committee members emphasized that such a directive did not signify a commitment to near-term action. The Committee will need to evaluate additional information on the balance of aggregate supply and demand and conditions in financial markets. |


Most updated information on covid case, vaccine, and test information as shown through graphs and interactive maps.
Medical Services
Doctors Without Borders
Relief Supplies: Health & Medical
Direct Relief
Cross-Categorical
CDC Foundation
Education & Awareness
National Foundation for Infectious Diseases
Relief Supplies: Community Support & Services
Crisis Aid International
----------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------------


R/fit_g_mc_variableJ.R
fit_g_mc_variableJ.Rd
Fitting mesophyll conductance with the variable J method
fit_g_mc_variableJ( data, varnames = list(A_net = "A_net", J_etr = "J_etr", C_i = "C_i", PPFD = "PPFD", phi_PSII = "phi_PSII"), usealpha_Q = FALSE, alpha_Q = 0.84, beta_Q = 0.5, gamma_star, R_d, P = 100 )
| data | Dataframe |
|---|---|
| varnames | Variable names to fit g_mc. varnames = list(A_net = "A_net", J_etr = "J_etr", C_i = "C_i", PPFD = "PPFD", phi_PSII = "phi_PSII"), where A_net is net CO2 assimilation in umol m-2 s-1, J_etr is linear electron transport flux in umol m-2 s-1, C_i is intercellular CO2 concentration in umol mol-1, PPFD is incident irradiance in umol m-2 s-1, phi_PSII is the operating efficiency of photosystem II. |
| usealpha_Q | Recalculate electron transport with new absorbance value? |
| alpha_Q | Absorbance of photosynthetically active radiation |
| beta_Q | Partitioning of absorbed light energy between PSI and PSII |
| gamma_star | Photorespiratory CO2 compensation point in umol mol-1 |
| R_d | Respiration rate in umol m-2 s-1 |
| P | Atmospheric pressure in kPa |
fit_g_mc_variableJ fits mesophyll conductance according to Harley et al. 1992. It also tests the reliability of the calculation and calculates a mean with only reliable values. Note that the output is in units of umol m-2 s-1 Pa-1.
Harley PC, Loreto F, Di Marco G, Sharkey TD. 1992. Theoretical considerations when estimating mesophyll conductance to CO2 flux by analysis of the response of photosynthesis to CO2. Plant Physiol 98:1429 - 1436.
# \donttest{ # Read in your data # Note that this data is coming from data supplied by the package # hence the complicated argument in read.csv() # This dataset is a CO2 by light response curve for a single sunflower data <- read.csv(system.file("extdata", "A_Ci_Q_data_1.csv", package = "photosynthesis" )) # Note: there will be issues here if the alpha value used # for calculating ETR is off, if gamma_star is incorrect, # if R_d is incorrect. data <- fit_g_mc_variableJ(data, varnames = list( A_net = "A", J_etr = "ETR", C_i = "Ci", PPFD = "Qin", phi_PSII = "PhiPS2" ), gamma_star = 46, R_d = 0.153, usealpha_Q = TRUE, alpha_Q = 0.84, beta_Q = 0.5, P = 84 ) # Note that many g_mc values from this method can be unreliable ggplot(data, aes(x = CO2_s, y = g_mc, colour = reliable)) + labs( x = expression(CO[2] ~ "(" * mu * mol ~ mol^ { -1 } * ")"), y = expression(g[m] ~ "(mol" ~ m^{ -2 } ~ s^{ -1 } ~ Pa^ { -1 } * ")") ) + geom_point(size = 2) + theme_bw() + theme(legend.position = "bottom")# Plot QAQC graph according to Harley et al. 1992 ggplot(data, aes(x = CO2_s, y = dCcdA, colour = reliable)) + labs( x = expression(CO[2] ~ "(" * mu * mol ~ mol^ { -1 } * ")"), y = expression(delta * C[chl] * "/" * delta * A) ) + geom_hline(yintercept = 10) + geom_point(size = 2) + theme_bw() + theme(legend.position = "bottom")# }


Your answers
This section is: Trust or Company Service Provider
What kind of Trust or Company Service Provider are you?
Answer:- Registered office, business address, and/or virtual office services provider
- Trust or company formation agent
- Do you sell only off-the-shelf companies? No
- Do you create complex corporate structures for clients, or are you planning to do so in the future? Yes
Which services does your business provide?
Answer:- Email handling
- Mail forwarding
- Self-collect mailboxes
Does your business use the services of another trust and company service provider?
Answer: Money Laundering Regulation reference number: 9327 1752


It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using 'Content here, content here', making it look like readable English.
Kale is great, because... It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using 'Content here, content here', making it look like readable English.It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using 'Content here, content here', making it look like readable English.
Italian kale is clearly superior, because It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout. The point of using Lorem Ipsum is that it has a more-or-less normal distribution of letters, as opposed to using 'Content here, content here', making it look like readable English.It is a long established fact that a reader will be distracted by the readable content of a page when looking at its layout.


Australia to announce gender parity pay deal - report
The Australian women's national soccer team will earn the same match pay as their male counterparts and have an equal split of commercial revenues for the first time under a new deal, local media reported on Tuesday.
MELBOURNE: The Australian women's national soccer team will earn the same match pay as their male counterparts and have an equal split of commercial revenues for the first time under a new deal, local media reported on Tuesday.
The national men's "Socceroos" team have historically been paid more than the women's "Matildas" and earned a greater share of commercial revenues.
But players had agreed in principle with governing body Football Federation Australia to strike a deal to ensure pay parity, Sydney's Daily Telegraph newspaper said.
The players' union, Professional Footballers Australia, declined to comment on the detail of the deal but confirmed all parties were working toward the goal of gender parity in pay.
A PFA spokesperson said it hoped the deal would be announced in coming days.
Pay disparity between men's and women's professional footballers has been in the spotlight since the U.S. women's team sued governing body U.S. Soccer in March alleging gender discrimination in earnings and working conditions.
Australia's Matildas launched a campaign to pressure global soccer governing body FIFA to provide equal prize-money at World Cups ahead of the women's tournament in France earlier this year.
The U.S. women's team received US$4 million for winning the World Cup in France out of the tournament's total prize-money pool of US$30 million.
In the 2018 men's tournament in Russia, winners France banked US$38 million from a pool of US$400 million.
(Reporting by Ian Ransom; Editing by Peter Rutherford)


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| API Version: | Adapters Loaded: | ||
| Server Start Time: | Server Up Time: |
| Exposure (s): | Trigger Mode: | |||||
| Acq Period (s): | ||||||
| Num Images: | Acquire: |
FR 1 |
FR 2 |
FR 3 |
FR 4 |
|
| Connected: | ||||
| Buffer Manager: | ||||
| RX Thread: | ||||
| Decoder: | ||||
| IPC: | ||||
| Configuration Complete: | ||||
| Empty Buffers: | ||||
| Frames Received: | ||||
| Frames Timed Out: | ||||
| Frames Released: | ||||
FP 1 |
FP 2 |
FP 3 |
FP 4 |
|
| Connected: | ||||
| Shared Memory: | ||||
| Processes | ||||
| Rank | ||||
| File | ||||
| Writing | ||||
| Frames Written |
| Frames To Write: | |
| File Path: | |
| File Name: | |


{% extends 'cmstemplates/inspire/layouts/contentfull.html' %} {% block title %} {{ page.title }} {% endblock %} {% block main-content-center %}
You do not have any pages published for this section of the website. You can add pages by editing this page.
This page is only accessible to website managers and publishers.


For review
section of the sidebar.Add new
on the top of the screen.Save draft
.You can come back and edit the article any time. Please remember that every time you click Save
, Forestry pushes a commit to GitHub. You can view your file in the DevCenter repository.
NOTE: it is recommended to create a new article in an external editor, such as Atom, and work on it there until it is ready for review. Ideally, you should only save a new article on Forestry when it’s done - that way the entire new article is a single commit on GitHub.
For review
section.NOTE: Once again, it is recommended to edit the existing article in an external editor until it is ready for review. Once you are finished (the article is ready for review), copy the contents into the new article you created in the For reviews
section. This is to ensure all changes are visible in a single commit.
NOTE: if you have several articles ready for review, you will find each article in a separate commit.


Text Play
Text effects such as fluid-headers, engraving, or neon.
fluid-header experimental
fluid-header sample. Works well for a lot of text. Resize your browser for a demonstration.

fluid-header sample. Works well for a lot of text. Resize your browser for a demonstration.

Create a

tag within a
tag and apply the fluid-header
class to the
tag. This bestows adaptive behavior to the header so that it grows or shrinks according to the viewport size.
text-engraved experimental
Engraved

Engraved

Engraved

Engraved

Engraved

Engraved

Create a container for your text such as a

tag or

tag, and apply a text-engraved-[color]-bg class such as text-engraved-black-bg
.
text-neon experimental
Neon

Neon

Create a container for your text such as a

tag or

tag, and apply a font-neon
class and a text-neon
class.
Neon

Neon

Create a container for your text such as a

tag or

tag, and apply a font-neon
class and a text-neon-2
class.


{% extends 'base.html'%} {% block content %} {% if form.errors %}
Check values that you entered
Not authorized to access that page
Username: {{form.username}}
Password: {{form.password}}


new Sortable(example1, { animation: 150, ghostClass: 'blue-background-class', forceFallback: true, fallbackAxis: "y" });
Try dragging from one list to another. The item you drag will be cloned and the clone will stay in the original list.
new Sortable(example3Left, { group: { name: 'shared', pull: 'clone' // To clone: set pull to 'clone' }, animation: 150 }); new Sortable(example3Right, { group: { name: 'shared', pull: 'clone' }, animation: 150 });
Try sorting the list on the left. It is not possible because it has it's sort
option set to false. However, you can still drag from the list on the left to the list on the right.
new Sortable(example4Left, { group: { name: 'shared', pull: 'clone', put: false // Do not allow items to be put into this list }, animation: 150, sort: false // To disable sorting: set sort to false }); new Sortable(example4Right, { group: 'shared', animation: 150 });
new Sortable(example5, { handle: '.handle', // handle's class animation: 150 });
Try dragging the item with a red background. It cannot be done, because that item is filtered out using the filter
option.
new Sortable(example6, { filter: '.filtered', // 'filtered' class is not draggable animation: 150 });
Try modifying the inputs below to affect the swap thresholds. You can see the swap zones of the squares colored in dark blue, while the "dead zones" (that do not cause a swap) are colored in light blue.
new Sortable(example7, { swapThreshold: 1, animation: 150 });
NOTE: When using nested Sortables with animation, it is recommended that the fallbackOnBody
option is set to true.
It is also always recommended that either the invertSwap
option is set to true, or the swapThreshold
option is lower than the default value of 1 (eg 0.65
).
// Loop through each nested sortable element for (var i = 0; i < nestedSortables.length; i++) { new Sortable(nestedSortables[i], { group: 'nested', animation: 150, fallbackOnBody: true, swapThreshold: 0.65 }); }
The MultiDrag plugin allows for multiple items to be dragged at a time. You can click to "select" multiple items, and then drag them as one item.
new Sortable(multiDragDemo, { multiDrag: true, selectedClass: 'selected', fallbackTolerance: 3, // So that we can select items on mobile animation: 150 });
The Swap plugin changes the behaviour of Sortable to allow for items to be swapped with eachother rather than sorted.
new Sortable(swapDemo, { swap: true, // Enable swap plugin swapClass: 'highlight', // The class applied to the hovered swap item animation: 150 });


Thoughts on life, programming, science, and the occassionally obscure philosophy reference.
Hi, I'm James. I'm learning to program! Thank you for joining me on this journey.
I'm a student at DBC in San Francisco. A native of Los Angeles and graduate of UCLA (Go Bruins).
If you have any questions, feel free to ask me at anytime! I'm mostly available 24/7 on one of many electronic devices attached to my body.
More to come soon... something quirky.


Create a public username.Share your username.  Just order the test kit.
Verify your identity to access to exclusive features. Just upload your identity card.


Hi, I like to develop software
METRONOM is METRO’s tech unit
B2B Wholesale Company
Everything is fine when everything is fine
The Evil bug
When you are in a bad situation, who can help you
Things are in order
As you fail you learn
Obvious is powerful
Small gains Big gain
A familiar tool that is more powerful than you thought
manifest.json
{
"name": "Getting Started Example",
"version": "1.0",
"description": "Build an Extension!",
"manifest_version": 2
"content_scripts": [
{
"matches": ["yourUrl"],
"js": ["inject.js"]
}
],
"permissions": ["yourUrl"],
}
This is the demo
and the REPL
and the IDE
Show the code!!!
Driver tours
//Map reduce JSON with js (locally)
//HERO is a global injected by
//our extension
await HERO.getTours("2020-02-02")
//all deliveries
.then(ts => ts.map( t => t.deliveries ))
.then(ds => ds.flat())
//of potatoes
.then(ds => ds.filter(d => d.article === "Potatoes" ))
.then(ps => ps.map(p => p.quantity))
//sum quantities
.then(ps => ps.reduce( (a, b) => a + b, 0 ) )
//Not only text
HERO.resetDb()
HERO.deliveries(1)
HERO.logo()
HERO.alreadyLoadedOnDate("2020-02-02")
//Set any delivery to completed
HERO.setTourToFinished(id)
#METRONOMians #codetalkshh
Image credits (Unsplash):


abstract var maxAge: AgeOfData
Used to set how old cached data can be on the device before it is considered too old and new cached data should be fetched.


OK
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Sync receiver state with media element
Update the playback, seek and volume state as the receiver state updates.
Stop receiver playback on page unload
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Sites for which to replace the user agent string with a Chrome version for compatibility. Must be valid match patterns.
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INC
☰ Menu
You all must be wondering what INC stands for , it is INDIAN NATIONAL
CONGRESS or famously known as CONGRESS . From its foundation on 28
December 1885 by A.O. Hume, a retired British officer, until the time
India gained its independence on 15 August 1947, the Indian National
Congress was considered to be the largest and most prominent Indian
public organization, as well as the central and defining influence of
the long indian independence movement.
Some of its early members were
● William wedderburn
● WC bonnerjee
● Surendernath bannerjee
● Mg remade
And many more.
WC bonnerjee was selected as a leader of the INC in 1885. The party was
formed to fight for basic rights for living which had been taken away by
the British government which was ruling over INDIA. Indians at that time
face extreme discrimination and frequent famines due to negation from
the british. INC was formed to gain political power and help expel the
British from the Indian subcontinent as not only present day India but
Pakistan and Bangladesh were also included. This party was started to be
recognized after 1920 when the famous freedom fighter of India Mahatma
Gandhi became the leader of INC . They started a lot of nationalism
movements and became the backbone of the Indian struggle for freedom .
With constant pressure put by the British government to subdue the
freedom movement INC fought back by launching movements like
● Khilafat movement
● Swadeshi movement
● Non cooperation movement
● Civil disobedience movement
● Poorna swaraj movement
Some of the facts we all must know about the olden day Congress party is
that all the movements organised by them were only peaceful protests and
when they took violent turns they were called off . many rules were
broken by the important leaders in order to persuade people to come out
to fight the British government which now had been ruling over the
Indian subcontinent for 200 years starting from the Bengal province to
the entire nation and in this process they were sent to jail for many
times. Sometimes they were sent to jail for no reason under the Rowlatt
act.
Pandit Jawaharlal Nehru the first prime minister of free India became
the president of the INC in the Lahore session of 1929. He later on
continued to lead the party to its glory and by the peak time of 1945
when world war 2 ended the promise made by the British to leave Indian
subcontinent was to come in force . The round table conference later
helped to specify the demands made by Indians on how they would like the
British to leave India to itself. This just a brief history of how the
INC became the major political power from India in its freedom struggle.
There are many mysteries yet to be discovered about this politically
legendary party. There will be more articles to come up about this topic
in the future so please hold on for them.
Himank Jain
Writer
Philomath Team


Breitbart Launches 'B Inspired News' on Instagram
The left believes in a different America. That’s what they’re selling, and the only way to sell something different is to point out the flaws in what currently exists. That’s what the left does. It has to. It has to object to the fundamental character of America in order to justify its desire to change it.
by Breitbart NewsAt Breitbart News, we love America and believe in its exceptionalism. We believe in the American spirit.
To that end, we are proud to introduce a brand new Instagram page called B Inspired News that will showcase true stories that we feel represent the inherent goodness of Americans.
We hope you FOLLOW B INSPIRED NEWS now, because every day in America, somebody does something amazing.


| Need: | The general population is unable to easily access accurate health information. Searching online for health information is the most well-adopted digital health category, with 40% of those who search acting directly upon what they find. |
| Objective: | Enable the general population to receive health care results explained in a simple, meaningful manner. |
| Approach: | Developed web application that is simple, free, and efficient to use. |
| Project Duration: | 3 days; Summer 2017 |
| Group Members: | Joanne Bruno (CEO), Jeremy Cantu (CTO), Lauren Welch (COO), Ana Cruz (Developer), Ivan Lopez (Lopez), Rob Quinn (Developer) |
| My Role(s): | CEO, Project Champion, Speaker (for project pitch to investors panel) |
| Final Result: | Angular 2 Web application functional prototype delivered. Project pitch to mock investor panel received overwhelmingly positive feedback. Traction was gained with several existing healthcare companies. |
In the healthcare industry, I find it increasingly complex to manage and understand my health care data. Before the vision
for uKnowHealth occurred to me, I had a close relative almost missed a very important abnormality on their health care
lab result data (sent via patient portal), which could have been found more quickly if the data was reviewed digitally
and translated to a more meaningful result. Luckily, this relative is has a professional degree in medicine, and was able
to understand her health care results and notify the doctor for a follow up. Their advanced health literacy saved their
life.
This situation gave me the following questions: What if this patient had not had the health literacy to be able to understand
this data? How can we better enable the general population to increase their health literacy and understand their health
care results?
At Startup Weekend Hackout, I created a balanced team of strong developers, and a subject matter expert in healthcare. After
working through some market research, we found a few interesting points that we wanted to expand on:
(1) Searching online for health information is the most well-adopted digital health category, with 40% of those who search
acting directly upon what they find.
(2) There has been a steady increase in mis diagnoses in recent years. Majority of diagnostic errors could have been prevented
if an AI tool could analyze systems and help doctors arrive at a diagnoses.
We put these ideas to the test by conducting a survey in the Austin Domain area. We wanted to identify basic health literacy
and where the users go to understand their numbers. Through this study, out of 26 responses, over 61% of patients attempt
to search online for more information on their healthcare results. We identified that the majority of respondents were
not able to identify what level of blood sugar or cholesterol is high, indicating lower health literacy than expected.
When prompted if they would pay for a service that allowed them to better understand their medical information, about 50%
suggested that it cost between $15-$90 per month, and others suggested it be free.
Based on our findings, our team worked together to develop wireframes for a web application that would allow the use to
receive more meaningful results based on their health care data results. The user enters a query of a medical term such
as "cholesterol" and enters their data from their most recent lab result, including standardization information such as
sex, age, etc. The application then lists a visualization slider with color indication of the result based on how it falls
within the data values for their selection. Based on their result, articles or further information from partnerships will
show at the bottom of the screen to further educate patient on what their results mean.
Team member Lauren Welch and I ran through our business model to solidify our vision and marketable value. This was a challenging exercise that thoroughly helped me understand what UX problem we are trying to solve and who is it really going to help. I want to use this same methodology for any problem I solve going forward to focus in on the problem statement, use case, and have a solid deliverable.
As the team consisted of members with varying degrees of development experience and fields of expertise, it was decided upon to utilize the Angular 2 library for creation of the high-fidelity prototype. The library's component-based workflow allowed members to quickly ideate, create, and integrate each particular slice of "functionality" for the prototype, as well as give the opportunity for the team to get familiar with a relatively cutting edge web-development tool set. This included using the Angular CLI for extremely quick boilerplate code creation, as well as the Angular Material library and design system to derive much of our end-user interface. The below walk-through showcases some of the prototype presented:
Final Project Walkthrough
I delivered a 5 minute pitch to a mock investors panel. The judges asked us many questions on how we were going to get this
item to market, knowing that the healthcare industry is highly complex versus other industries. The judges were impressed
on how much we delivered over the course of a weekend versus the other teams.
Overall, we developed a recognized business model, a functional prototype for a web application, a successful project
pitch. The biggest challenge was narrowing down the scope of the project to a single, solidified idea that the end user
would find valuable. However, we overcame this through extensive market research and entrepreneurial exercises. I firmly
believe that our final product deliverable will help health care results be made simple and meaningful.
Thank you for reading! If this work interested you, check out some of my other projects in healthcare, such as Medidata


| Feature Article - February 2000 | |||
|
Chris Jackson is an Associate Professor at Nova Southeastern University in Fort Lauderdale, Florida. She teaches writing, literature, and music history.
|
Picturing the President: The West Wing By Chris Jackson
Ratings and Golden Globe nominations make it official. NBCs The West Wing has the voters approval as THE SHOW to watch. And why not? Writer Aaron Sorkin has whipped up a show with razor sharp dialogue, engaging story lines, and carefully orchestrated ensemble acting. Its fine dramatic quality aside, The West Wing commands our attention here in Picturing Justice for a number of reasons. The legal profession features prominently on the resume of many of the shows characters. They struggle with ethical dilemmas and present diverse perspectives on thorny current issues. Were also afforded an intriguing look at how ideas become policy and how a bill becomes law. We see research, planning, and compromise. We see close-up how people make laws and sometimes end up breaking lawmakers. Most significantly, however, is the shows inaugural one TV season before an election year. As popular culture, this portrait of President Josiah Bartlet (Martin Sheen) and his staff is clearly a Democrats wish fulfillment. Small screen images of "reality" unsettled us as a country: a young girl in a beret, a stammering President, impeachment hearings. Its only natural that television should put Humpty back together again. The West Wing allows the country a quiet healing after the scandals of the Clinton administration. Its presentation of well-intended, intelligent professionals doing battle for good is a balm over our collective psyche. Popular culture may have a better opportunity to shape political opinions than actual events. In Why Americans Hate Politics (1992), E. J. Dionne, Jr. illustrates the American publics growing disenchantment with the political process. As one reason, Dionne cites the two-party penchant for misrepresenting policy issues. However, we also must consider how most of us learn about events Washingtonian. TV and print news seems to pelt us with coverage, but ultimately our view of whats really going on is limited. CSPAN affords another look at official Washington, but the tedium alone is a killer. All the drama and risk happens off the speakers dais. Nonfiction literature can present an in-depth view of events, but memoirs and biographies reach us long after the fact. They must. Revealing too much too soon incurs a high political risk. Films are better mirrors, even if they are funhouse mirrors, of what people think of Washington at the time they think it. Lets take a peek. Presidents in films range from being ruthless to charming and many degrees in between. Seven Days in May (1964) shows the President, played by Frederic March, fending off a military takeover. Although Marchs character prevails, this film shows the vulnerability of the Presidency. Made during escalated fighting in Vietnam, the film reflects a publics fear that a military coup was not beyond the realm of possibility. Dave (1993) features Kevin Kline as a two-in-one President. He plays both a Machiavellian leader, then a flannel shirt wearing lookalike who fills in for the comatose Prez. Only First Lady Sigourney Weaver tips to the deception. What better way to capture for the public mind the transition from a Republican White House to one under Democrat rule?
Based on the Clancy novel, Clear and Present Danger (1994) revives the elder statesman Presidential image. Harrison Fords Jack Ryan reports to a corrupt President in bed with corporations and willing to authorize cover-ups. This film comes in the wake of Iran/Contra and other covert operations. These transgressions were never fully explained to the public satisfaction. "Mistakes were made."
The President dating? Okay, we can imagine it now, but five years ago, the idea felt new. The American President (1995) shows us widower Prez Michael Douglas and lobbyist Annette Bening in a convincing White House romance complete with conflicts of interest. Portraying a humanized leader, this film was an internship, so to speak, for screenwriter Aaron Sorkin. The young guy as Prez continues with Bill Paxtons turn as Commander in Chief for Independence Day (1996). A skilled fighter pilot, he and Will Smith send those evil extraterrestrials packing. In Air Force One (1997), Harrison Ford doesnt report to the President; he is the Big Guy himself. Ford is lithe and impressive as an action hero who saves his family and staff from terrorists. Both movies may reflect a public disappointment in Clintons missing military background. Otherwise, these presidential portraits are a liberals dream. But the dream fades. Joe Kleins Primary Colors was one book that didnt wait long enough to tell-all about mud on the campaign trail. The film based on Kleins book (1998) was released a week after Clintons deposition on the Paula Jones case. It gives us John Travolta as Southern-inflected candidate Jack Stanton. He is soft and gooey, like the donuts he mashes into his face. In 1997-1998, Murder at 1600, Absolute Power, and Wag the Dog follow in quick succession. All three reek with scandal and wrongdoing at the Top. Unlike film, the small screen is overwhelmed with Presidential reality, press conferences, sound bites, photo ops. Before The West Wing, presidential parody was the best TV could offer. Nixon appeared on Laugh-In and every President since then showed up some way or other on Saturday Night Live. Benson was a long-running sitcom during a time of growing political influence for minorities. Hearts Afire, written by MFOBs (Major Friends of Bill) Harry Thomason and Linda Bloodworth, lasted only a season or two. Showing the daily struggles of a Washington staff, the show is closest in spirit to Sorkins The West Wing. From the outset, The West Wing sets a disclaimer: We are fiction. Opening credits show a filmy flag waving across an image of the White House. The theme music is by W.G. Snuffy Walden. Stirring, stately, with lots of brass, I thought the tune vaguely Copland-esque the first time I heard it. Now it seems more like the theme from Wagon Train. "Westward ho! Round up those dogies." Were supposed to be in mythic territory here. I dont buy this little ruse for a second. When Primary Colors first came out, all Washington had fun aligning fiction with fact. We can play a similar game here. Analogies to the Clinton White House are inescapable. The Big Two are Josiah, called Jed, Bartlet (Sheen) and wife Abigail (Stockard Channing). They are both personally charming, but consummate, hardheaded politicians. They know how to work the room and the system. Sound familiar? Bartlet, or POTUS (President of the United States), is brilliant and capable, a Nobel Prize Winner in Economics, but we see his flaws. Great in the role, Sheen played Chief of Staff in Sorkins The American President. Like Harrison Ford, he earned a promotion. The First Lady is a professional in her own right, an MD. She is media-savvy, sophisticated, and often on the road. She also rules him. "Uh oh," he says about her imminent return. Their daughter Zoey is a freshman at Georgetown. There could even be a Monica parallel. We hear in passing about a young intern moved from one office to another because of a crush on the Vice-President. Chief of Staff Leo McGarry (John Spencer) will go to the mat for long-time friend Jed. He also has personal problems, a broken marriage and past treatment in a Betty Ford-like center. Before his wife leaves for the Watergate, he pleads for her to understand. "This job is the most important thing I will ever do." She asks, "More important than your marriage?" she asks. His answer is unequivocal: "Yes." Do not confuse the fictional McGarry with the real former Chief of Staff Dick Morris. Was Morris separated? Did Morris have to deal with a personal scandal? (There was a certain hotel balcony video.) Head Speechwriter Sam Seaborn (Rob Lowe) is a Princeton lawyer, brilliant, with high standards. Now who among the Clinton crew (George) might that be (Stephanopolis)? C.J. Cregg (Allison Janney) is White House Press Secretary. She knows her stuff and is one of the guys, joking with the reporters. The fact that she goes by her initials does not link her at all to any former women Press Secretaries. (Did we mention that Dee Dee Myers is a consultant for the show?) We may see these parallels, but the more we watch, dont confuse us with the facts. We care about these TV people more than we ever cared about Dick Morris. The ensemble acting is terrific. The West Wing uses a Mary Tyler Moore Show strategy. People enmeshed at work become a type of family. Characters fit into family archetypes. Dad, of course, is Sheen. Weve already seen him taking real life wayward son Charlie to task. The Mom of this crew is not The First Lady. Shes too young and busy to mother anyone, even daughter Zoey. The mother is Jeds secretary, Mrs. Landingham. Jed whines to her. "Where are my reading glasses?" Another encounter runs like this: "Id like a banana now," he says to her. "I dont think so," she replies. "I wanted to give you one before, but you were quite snippy, sir." Jed is a modern Dad, vulnerable. Leo is the slightly shady, black sheep uncle who comes through when seas turn rough. He calms Dad down with raucous humor before the State of the Union. Sam, Deputy Chief of Staff Josh (Bradley Whitford), and Communications Director Toby (Richard Schiff) are the sons willing to defend their Dad, no matter the cost. Josh and Sam go to The Hill to wrangle with a Senator sporting a Barney Frank-like accent. "This is what happens when we let kids into the White House," the Senator huffs.  These folks share a major callingduty. They eat and sleep in their offices and dont have time to fetch clothes from the cleaners. "Isnt that the same suit you wore yesterday?" one asks. "Yup." Because they are so busy romancing Congress, no one on the West Wing has time for a relationship. The first episode showed Sam in bed with a woman.  Sam has to rush off because POTUS had a bicycle accident. He later discovers his paramour is a high-priced call girl. He has to drop her. Josh and Mandy (Moira Kelly) were a couple, but he finds a picture of them with his face scribbled out. No hope there. For a possible affair, watch C.J. and Danny, a White House reporter (Timothy Busfield). Their courtship is hot, yet business-likedirect soulful stares, rushed kisses. Pillow talk between them could get conflict of interesting. The claustrophobic sets differ from the Early Corporate of most TV dramas. Were almost in a different century, despite trilling cell phones and clackety copiers. The staffers work out of cubbyholes that barely contain their energy. Hand-held cams follow them around corners of narrow halls, down elegant staircases. The dim lighting comes from garish sconces. This constraining, museum-like backdrop reflects the shows major tension: human foibles held in check by the tradition of the presidency. This includes POTUS himself. To retaliate for a terrorist attack, Bartlet wants to bomb a small but aggressive country into submission. The Joint Chiefs recommend a "Proportional Response." He angrily questions their advice. Despite some tight moments, he responds as they suggest. No imperial Presidency here. Dwellers of the West Wing are flawed, mostly well-intended people. In every encounter so far, their personal ambitions lie down before the majesty of the office, highly unexpected in these times of a supposed cult of personality. Sure, they admire Bartlet, but the Presidency, with a capital P, keeps them on point. The Staff presses hard on issues ripped from the headlines: sex education, hate crimes, capital punishment, Supreme Court nominee confirmation, gun control. Always, they face the line between compromise and sell-out. "There are two things in the world you never want people to see how you made them: laws and sausages." Leo McGarry, Chief of Staff. Call this backstage high school Civics. The episode Five Votes Down shows us the sometimes unsavory trade-offs needed to pass a Bill, in this case gun control. Bartlet stays above this arm-twisting for votes. He is cuddly in a sweatshirt and mentally fuzzy from pain pills. He hugs people like a sappy drunk. The staff humors him. "President Bartlet doesnt hold a grudge. Thats what he pays me for," Leo says. Josh also tries to win back votes before the official tally. He meets with a former fraternity buddy, now a Congressman. The camera swirls around the two pugilists. Josh knows the Bill cold, whereas his counterpart only wants to win re-election. In many shows, members of Congress come across either as charming snakes or thugs in expensive suits. When Josh says, "I am so sick of Congress, I could vomit," we may share the sentiment. The West Wingers have perfected deal-making and the art of the cover-up. They might, for instance, "take out the trash." This strategy unveils an explosive story on Friday night, because Saturday has slow news coverage. C.J. wants to tip White House reporter Danny to a real story in the trash. He says, "Dont tell me; Ill find it." She responds, "Im not sure you will, because weve gotten so good at this." The Staff usually wins, ultimately, but victory feels like flat champagne. Their unethical ways and means take a personal toll. Our political landscape has shifting sands, and much can happen between now and November. Still, The West Wing speaks to voters in a strong voice. That voice says, Despite everything, vote for another Democrat.
My thanks to PJ Webitor Paul Joseph, Lynn Wolf, and Lauren Brays "An Unofficial Tribute to the West Wing" website for help as I prepared this article. Posted February 14, 2000
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