Motivation
During our literature survey, we found that numerous designs have been proposed for biosensors. Each design works pretty well for the target it was designed for, initially. However, many times, its adaptability for use with other molecules remains a question. We feel that this is a major drawback for a technology having such great potential. There should exist a universal design for biosensors in general which can be easily adapted to use with a large variety of molecules. This would not only reduce the amount of time and resources required for development of these sensors but would also lead to their increased presence in our daily lives.
Our team has taken up challenge to create such a universal design using hollow mesoporous silica nanoparticles and DNA origami based nanostructures.
DNA Origami
DNA origami is nanoscale folding of DNA strands to desirable shapes. These structures are stable in being less susceptible to enzyme attacks than bare nucleic acid strands. They are a hot topic for current research as they have various applications like drug delivery, nanoelectronic circuitry, enzyme immobilisation, DNA nanorobots etc.[1] The design of the desired shape is made by raster filling the shape with kilobases long DNA strand, held in place with the help of short oligonucleotide ‘staple strands’. The strands self-assemble to nanometer scale structures once, mixed together.[2] Finally, these individual structures can be made into large assemblies useful for targeted drug delivery, enzyme immobilisation etc.
The technique of DNA origami started with the work of Paul Rothemund when he used 7kB scaffold strands and 200 base long staple strands to create “smiling face” structures. [2]
CADNano is a CAD based program that gives a platform for designing DNA origami structures. The staples are to be designed according to the structure and complementary to the scaffold strand within the program.
Forster Resonance Energy Transfer(FRET)
FRET is a distance dependent resonance energy transfer between two dye molecules without the emission of photons. A fluorescent donor is excited at its specific fluorescence excitation wavelength. By long range dipole-dipole coupling mechanism, this excitation energy is then non-radiatively transferred to a second molecule, the acceptor, while the donor returns to the ground state.
The conditions that need to be met for FRET to occur[3]:
-
The donor and the acceptor must be 10-100 Å apart.
-
The donor and acceptor dipoles must be approximately parallel.
-
The absorption spectrum of the acceptor must overlap with the emission spectrum of the donor.
We use fluorescein (green) as the donor and rhodamine (red) as the acceptor. When the two dyes are at a distance less than the Forster distance the emission of the donor dyes excites the red dye. As a result only red fluorescence is seen. However, when the dyes are farther apart, the efficiency of energy transfer from the green dye to red dye decreases hence leading to a yellow colour (due to both the dyes simultaneously fluorescing).
FTIR
Fourier transform infrared spectroscopy (FTIR), uses infrared spectroscopy and then runs the data through a fourier transform to get the final results.
Infrared spectroscopy involves excitation of sample using infrared region of the light spectra. A graph of percent transmitted versus wavenumber is obtained for analysis.
The data gives a detailed insight of the different types of bonds present in our sample. On comparing with a standard table/ graph we can estimate accurately the presence/ absence of particular bonds, thus allowing us to characterise the chemical nature of our sample.
In FTIR, different combinations of light frequencies are irradiated onto the sample at different time points. This gives different sets of transmittance/absorbance data points for each combination of frequencies. All these data points are consolidated using Fourier transform,which produces a final data set of different absorbance/ transmittance percentages at different wavelengths.
Applications
Versatile Biosensors
The nanoparticle based biosensors designed by our team can be adapted to perform a wide range of sensing functions. In theory, anything for which an aptamer can be made, can be sensed using a variant of our biosensor.
Compound Biosensors
Not only can our biosensor sense a large variety of molecules one at a time, it can be used to create something we call “Compound Biosensors”. In this, donor tagged origami containing particles are gated with an aptamer sensitive to “Signal A” while the acceptor tagged origami containing ones are gated with an aptamer sensitive to “Signal B”. In such a case, a mixture of these 2 types of particles would give a red colour only in presence of both the signals, A and B. This is useful in complex sensing applications where the output to be tested is a result of interaction between multiple input signals.
High throughput Biosensing
The method of biosensing employed by these biosensors can be easily scaled up to accomplish high throughput biosensing. Multiple variants of the nanoparticle mixture, each having a different type of gate (different aptamer) can be immobilized in different wells of an ELISA plate. Now, each well would act as a biosensor for a particular target. The sample to be analysed can be added to each of the wells and fluorescence can be measured. Such an approach to biosensing can be very helpful in a multitude of scenarios. For example, a given water sample can be tested for a multitude of contaminants at once, hence giving a complete “water profile”. It can also be used in cancer diagnostics to detect multiple types of cancers.
References
-
Structural DNA nanotechnology: from design to applications Zadegan, R.M.; Norton, M.L (2012). "Structural DNA Nanotechnology: From Design to Applications".
-
Rothemund, Paul W. K. (2006). "Folding DNA to create nanoscale shapes and patterns". Nature
-
Paul Held (2005). “An Introduction to Fluorescence Resonance Energy Transfer (FRET) Technology and its Application in Bioscience”. BioTek


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--- layout: page title: "About" description: "Hey, this is Blog." header-img: "http://pqcjj2s3l.bkt.clouddn.com/assets:img:home-bg.jpg" ---


Paper: arXiv
Authors: Nobuyuki Morioka, Heiga Zen, Nanxin Chen, Yu Zhang, Yifan Ding
Abstract: Adapting a neural text-to-speech (TTS) model to a target speaker typically involves fine-tuning most if not all of the parameters of a pretrained multi-speaker backbone model. However, serving hundreds of fine-tuned neural TTS models is expensive as each of them requires significant footprint and separate computational resources (e.g., accelerators, memory). To scale speaker adapted neural TTS voices to hundreds of speakers while preserving the naturalness and speaker similarity, this paper proposes a parameter-efficient few-shot speaker adaptation, where the backbone model is augmented with trainable lightweight modules called residual adapters. This architecture allows the backbone model to be shared across different target speakers. Experimental results show that the proposed approach can achieve competitive naturalness and speaker similarity compared to the full fine-tuning approaches, while requiring only ~0.1% of the backbone model parameters for each speaker.
Click here for more from the Tacotron team.
Random samples from the models listed in Table 1 in the paper.
| Natural Speech | w/o backbone data | w/ backbone data |
|---|---|---|
| 1: | ||
| 2: | ||
| 3: | ||
| 4: | ||
| 5: | ||
| 6: | ||
Random samples from the models listed in Table 2 in the paper. 'rd' and 'rv' denote the bottleneck dimension of residual adapters in the decoder and the variance adapters respectively.
| Natural Speech | rd=16 | rd=128 | rd=16, rv=8 | rd=128, rv=64 | |
|---|---|---|---|---|---|
| 1: | |||||
| 2: | |||||
| 3: | |||||
| 4: | |||||
| 5: | |||||
| 6: | |||||
Random samples from the models listed in Table 3 in the paper.
| Natural Speech | 30 min | 5 min | 1 min | ||
|---|---|---|---|---|---|
| 1: | |||||
| 2: | |||||
| 3: | |||||
| 4: | |||||
| 5: | |||||
| 6: | |||||
Random samples from the models listed in Table 4 in the paper.
| Natural Speech | Residual Adapters | Fine-tuning (30 min + backbone data) | Fine-tuning (30 min) | Fine-tuning (5 min) | Fine-tuning (1 min) |
|---|---|---|---|---|---|
| 1: | |||||
| 2: | |||||
| 3: | |||||
| 4: | |||||
| 5: | |||||
| 6: | |||||
Random samples from the models listed in Table 5 in the paper.
| Natural Speech | Residual Adapters (1 min) | Residual Adapters (1 utterance) | Zero-shot d-vector (1 min) | Zero-shot d-vector (1 utterance) | Fine-tuning speaker embedding only (1 min) |
Fine-tuning speaker embedding only (1 utterance) |
|---|---|---|---|---|---|---|
| 1: | ||||||
| 2: | ||||||
| 3: | ||||||
| 4: | ||||||
| 5: | ||||||
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Your feedback can help to make Hextrapolate a better product. If you have general feedback that doesn’t fall into the categories of requesting a feature, reporting a bug or getting support please get in touch.
To submit feedback for Hextrapolate:
- Contact me via email to feedback@wincent.com.


You will first need to create a Cognos Dashboard Embedded service on IBM Cloud. Once created, obtain your Client ID and Client Secret from "Service credentials", and enter them below.
Client ID: Client Secret:Press the following button to create a Cognos Dashboard Embedded session. A Session Code will be returned to the client.
Press the following button to initialize the API framework. It will also register callback to API events, which provides the ability for your application to handle errors within the framework.
Press the following button to create a new dashboard. Press "OK" after choosing a layout template.
Select a previously saved dashboard in order to open it. This sample app persists dashboards as JSON documents in a Cloudant NoSQL database. Any previous dashboards you've created and saved (Step 6 below) using your Cognos Dashboard Embedded service Client ID will appear here.
Saved dashboards:
This sample app has a helpeful utility to assist with building data source specifications (JSON format) for Cognos Dashboard Embedded from a CSV URL. The first row of the CSV will be analyzed. Based on column names and data values, a "best guess" of the column's data type, usage, default aggregation, and taxonomy will be inferred. Make sure to just use this utility as a starting point, and make modifications to the data source specification as needed. Details on creating data source specifications for Cognos Dashboard Embedded can be found here.
Link to CSV file:
Provide a name for the data source:
Please wait up to 15 seconds for the data source spec to generate and populate the text area below.
Data Source Spec:
Interact with the canvas to create your dashboard. Try dragging a column from the Sources pane onto the canvas in order to create your first visualization. For example, if you're using the sample dataset, drag in "Quantity" to see the total quantity of products sold. Next, drag in "Product line" onto the same visualization in order to see a column chart breaking down quantity sold by product line. While building your dashboard, you can use the buttons in the "Additional Utilities" section below to undo, redo, and access the properties pane.
Generate a dashboard spec based on the current dashboard and save it to Cloudant. Provide the dashboard with a unique name below. Non-unique names will overwrite previous saved dashboards in the database.


Xlsxir v1.5.1 Xlsxir.Unzip
Provides validation of accepted file types for file path, extracts required .xlsx
contents to ./temp
and ultimately deletes the ./temp
directory and its contents.
Summary
Functions
Deletes all files and directories contained in specified directory
Extracts requested list of files from a .zip
file to ./temp
and returns a list of the extracted file paths
Checks if given path is a valid file type, returning a list of available worksheets
Checks if given path is a valid file type and contains the requested worksheet, returning a tuple
List of files contained in the requested .xlsx
file to be extracted
Functions
Deletes all files and directories contained in specified directory.
Parameters
dir
- list of directories to delete (default set for standard Xlsxir functionality)
Example
An example file named test.zip
located in ‘./test_data/test’ containing a single file named test.txt
:
iex> path = "./test/test_data/test.zip"
iex> file_list = ['test.txt']
iex> Xlsxir.Unzip.extract_xml_to_file(file_list, path)
{:ok, ['temp/test.txt']}
iex> Xlsxir.Unzip.delete_dir("./temp")
:ok
Extracts requested list of files from a .zip
file to ./temp
and returns a list of the extracted file paths.
Parameters
file_list
- list containing file paths to be extracted inchar_list
formatpath
- file path of a.xlsx
file type instring
format
Example
An example file named test.zip
located in ‘./test_data/test’ containing a single file named test.txt
:
iex> path = "./test/test_data/test.zip"
iex> file_list = ['test.txt']
iex> Xlsxir.Unzip.extract_xml_to_file(file_list, path)
{:ok, ['temp/test.txt']}
iex> File.ls("./temp")
{:ok, ["test.txt"]}
iex> Xlsxir.Unzip.delete_dir("./temp")
:ok
Checks if given path is a valid file type, returning a list of available worksheets.
Parameters
path
- file path of a.xlsx
file type instring
format
Example
iex> path = "./test/test_data/test.xlsx"
iex> Xlsxir.Unzip.validate_path_all_indexes(path)
{:ok, [0, 1, 2, 3, 4, 5, 6, 7, 8]}
iex> path = "./test/test_data/test.zip"
iex> Xlsxir.Unzip.validate_path_all_indexes(path)
{:ok, []}
Checks if given path is a valid file type and contains the requested worksheet, returning a tuple.
Parameters
path
- file path of a.xlsx
file type instring
format
Example
iex> path = "./test/test_data/test.xlsx"
iex> Xlsxir.Unzip.validate_path_and_index(path, 0)
{:ok, './test/test_data/test.xlsx'}
iex> path = "./test/test_data/test.validfilebutnotxlsx"
iex> Xlsxir.Unzip.validate_path_and_index(path, 0)
{:ok, './test/test_data/test.validfilebutnotxlsx'}
iex> path = "./test/test_data/test.xlsx"
iex> Xlsxir.Unzip.validate_path_and_index(path, 100)
{:error, "Invalid worksheet index."}


| Gender | Age | Age Groups | Race | Ethnicity | Index Year | Index Month | Prior Observation Time |
Post Observation Time |
Time In Cohort |
Index Year & Month |
|
|---|---|---|---|---|---|---|---|---|---|---|---|
| Demographics |
| Start Days | |
| End Days |
| Domain | Selected | |
|---|---|---|
| Any | Distinct | |
| Condition | ||
| Condition - Primary Inpatient | ||
| Drug | ||
| Procedure | ||
| Measurement | ||
| Measurement - Value | ||
| Measurement - Range Group | ||
| Observation | ||
| Device | ||
| Visit - Count | ||
| Visit - Concept Count |
| Domain | Selected | |
|---|---|---|
| Overlapping | Start | |
| Condition | ||
| Condition Group | ||
| Drug | ||
| Drug Group |
| CHADS2 | CHA2DS2VASc | DCSI | Charlson |
|---|---|---|---|


{% assign size = "" %}
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you might see me learning, studying, hacking.But nobody pays me a dime for that work. That's why I am learning and mastering web development. I will not stop until I become the Web Development Hero.
visit meI already learned the basic HTML and CSS. I can build any simple website. I can even teach my grandma how to make a simple website. My goal is to build 3 websites and learn advanced topics.
Email<EMAIL_ADDRESS>- Present | Pro Level Developer
2020 - Present | Pro Level Developer
I am the master of HTML, CSS and JavaScript. I know everything needed to make a website function efficiently. I didn't stop with the web. I went beyond with the most popular JavaScript framework called Vue JS. I even know the deployment, server and security. I will give you 100% web solution.
2019 - 202 | Programming Hero (Remote)
They didn't offer me a job. But I made myself as a remote web developer. I made their website and showed it to them. They liked it. And uploaded the content. It was fun working at Programming Hero.


Create a new World instance
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Register a system for addition. Systems are executed linearly in the order added.
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For your homework assignment, you will be given a coding challenge loosely based on the historic efforts of the WWII code breakers.
This challenge is inspired by the Lorenz cipher and Colossus computer used by the WWII code breakers at Bletchley Park.
There will be 5 questions you need to solve. Good Luck! Enjoy!
To obtain the questions for the challenge you will need to use a JSON service to request each question. An example on how to use the JSON REST API is found here: http://gist.github.com/602853
Please note that you will need to use the 'reference-url' attribute in the JSON data to get the information needed to solve the question. Once you have sucessfully completed a question, then you will be redirected to the next question in turn.
You can start the challenge by requesting http://minisculus-8lu.heroku.com/start.


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{% extends 'base.html' %} {% import 'macros.html' as macro %} {%block styles%} {{ super() }} {%endblock%} {%block content%}
Want to ace an interview in just a few words, welcome.
Want to talk about your products, you're in the right place.
Want to promote anything, step right up and begin.


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---
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title: "About my project"
permalink: /about-me/index.html
description: "Some description about Victor Igor..."
---
{% include head.html %}
{% include svg-icons.html %}
{% include menu-search.html %}
{% include scripts.html %}
Do you know my name? If you know my name that you can input the key know me.


Queen Maxima of the Netherlands to reach Pakistan on Nov 25
by https://www.facebook.com/dunyanewsISLAMABAD (Dunya News) - Queen Maxima of the Netherlands will visit Pakistan from November 25 to 27 as special advocate of the UN Secretary-General for Inclusive Financing for Development (UNSGSA). Queen Maxima visits Pakistan at the invitation of the government.
According to a statement received here on Friday from Pakistan Embassy the Hague, Netherlands, Queen Maxima will discuss the progress of access to financial services to improve the economic position of the country’s inhabitants during her visit.
Queen Maxima focuses, among other things, on the importance of financial services for women. Only seven percent them have a bank account and gender-based data collection is needed to understand their specific access and use needs.


I was recently puzzling over an academic paper in the social sciences with a multiple linear regression model that seemed off. (Communication with the authors educated me on considerations that resolved my concerns.)
During the course of my puzzling, I compared what I was seeing as model output in the paper and what I expected to see based on experience. The embarrassing revelation dawned that I didn’t actually know what all those components meant.
So, I decided to find out. Data on Seattle area housing prices provide a convenient way to illustrate the usual output of a multiple linear regression model output. This is a 21K dataset with 19 variables on housing characteristics and sales price.
## [1] "Data Structure"
## Parsed with column specification:
## cols(
## .default = col_double(),
## id = col_character(),
## date = col_datetime(format = "")
## )
## See spec(...) for full column specifications.
## cols(
## id = col_character(),
## date = col_datetime(format = ""),
## price = col_double(),
## bedrooms = col_double(),
## bathrooms = col_double(),
## sqft_living = col_double(),
## sqft_lot = col_double(),
## floors = col_double(),
## waterfront = col_double(),
## view = col_double(),
## condition = col_double(),
## grade = col_double(),
## sqft_above = col_double(),
## sqft_basement = col_double(),
## yr_built = col_double(),
## yr_renovated = col_double(),
## zipcode = col_double(),
## lat = col_double(),
## long = col_double(),
## sqft_living15 = col_double(),
## sqft_lot15 = col_double()
## )
##
## Call:
## lm(formula = price ~ bedrooms + bathrooms + sqft_living + sqft_lot +
## yr_built, data = house)
##
## Residuals:
## Min 1Q Median 3Q Max
## -1784413 -131451 -16905<PHONE_NUMBER>748
##
## Coefficients:
## Estimate Std. Error t value Pr(>|t|)
## (Intercept) 6.006e+06 1.298e+05 46.281 <2e-16 ***
## bedrooms -7.096e+04 2.246e+03 -31.592 <2e-16 ***
## bathrooms 8.114e+04 3.730e+03 21.755 <2e-16 ***
## sqft_living 3.044e+02 2.998e+00 101.544 <2e-16 ***
## sqft_lot -3.388e-01 4.119e-02 -8.225 <2e-16 ***
## yr_built -3.057e+03 6.686e+01 -45.730 <2e-16 ***
## ---
## Signif. codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1
##
## Residual standard error: 245800 on 21607 degrees of freedom
## Multiple R-squared: 0.552, Adjusted R-squared: 0.5519
## F-statistic: 5325 on 5 and 21607 DF, p-value: < 2.2e-16
Well now! I pick a handful of variables off the top of my head and presto! My model explains over 50% of the variation in price. Am I good or what?
Not really, and I’ll explain all the bonehead errors in another post (didn’t normalize, didn’t split into training and test sets, used variables that are not truly independent, didn’t check the distribution of residual errors and a host of other sins). Let’s talk about the information you get from a multiple linear regression results table.
- The Call is an explicit statement of the model.
- The Residuals show a summary distribution of the differences between the observations and predictions. In this example half of the residuals are about, low, up to $17,000 and and half are above, including one whopper that’s almost $4 million high.
- The Coefficients include, in addition to the coefficient and standard error, a t value and the probability that the coefficient is greater that the absolute value of the t value. It is essentially equivalent to the significance level – the probability, which is extremely low in this example, of the results being due to random effects.
- The Signif. codes are for convenient reference to the size of the significance level.
- The Residual standard error indicates the average amount that the observed values deviate from the trend line, in this case approximately $246,000.
- Multiple R Squared, indicates the proportion of variance explained by the coefficient, holding the other coefficients constant.
- Adjusted R Squared, accounts for possible interaction among the other independent variables.
- The F-statistic addresses the question of whether there is, in fact, no relation between one or more of the independent variables and the coefficient. An F-statistic that approaches 1 precludes us from rejecting the null hypothesis of no relation and to conclude that there is, in fact, no relationship at all between one or more of the independent variable with the dependent. The degrees of freedom equals the number of data points, minus 1. The p-value, or significance, gives the probability that the F-statistic is merely the result of random chance. The extremely low p-value in this example indicates that the F-statistic is highly unlikely to be a chance artifact.
As I said before, there are defects in my model that render these results garbage, and my table should be accompanied by a discussion that the conditions required to make multiple linear regression are actually unsatisfied. It’s solely to illustrate the information provided in the table.
Just goes to show you don’t really understand something you haven’t tried to explain.


| Home | Trees | Indices | Help |
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ListenedObject.ListenedObject --+ | GestureDispatch
A ListenedObject that is responsible for sending user gestures to handlers (which could, but not necessarily, be an AbstractController).
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dispatching Whether or not the GestureDispatch will send out events. |
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Returns whether or not the GestureDispatch will send out events. By
default, this is
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Sets whether or not the GestureDispatch will send out events.
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Private method. Receives mouse motion events from GTK. It constructs a MouseGestureEvent, then dispatches it via dispatchMouseMotionGesture.
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Private method. Receives mouse press events from GTK. It constructs a MouseGestureEvent, then dispatches it via dispatchMousePressGesture (or dispatchMouseDoublePressGesture if it was a double press). Note that, when a user double presses, two single-press events will be dispatched before the double-press event is dispatched.
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Private method. Receives mouse release events from GTK. It constructs a MouseGestureEvent, then dispatches it via dispatchMouseReleaseGesture.
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Private method. Receives mouse scroll events from GTK. It constructs a MouseScrollGestureEvent, then dispatches it via dispatchMouseScrollGesture.
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Private method. Receives key press events from GTK. It constructs a KeyboardGestureEvent, then dispatches it via dispatchKeyPressGesture.
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Private method. Receives key release events from GTK. It constructs a KeyboardGestureEvent, then dispatches it via dispatchKeyReleaseGesture.
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If currently sending out events, notifies listeners of a mouse motion. This may be used to manually fire an event.
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If currently sending out events, notifies listeners of a mouse press. This may be used to manually fire an event.
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If currently sending out events, notifies listeners of a mouse double press (that is, a double click). This may be used to manually fire an event.
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If currently sending out events, notifies listeners of a mouse release. This may be used to manually fire an event.
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If currently sending out events, notifies listeners of a mouse scroll. This may be used to manually fire an event.
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If currently sending out events, notifies listeners of a key press. This may be used to manually fire an event.
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If currently sending out events, notifies listeners of a key release. This may be used to manually fire an event.
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dispatchingWhether or not the GestureDispatch will send out events.
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| Generated by Epydoc 3.0.1 on Fri Apr 9 14:54:58 2010 | http://epydoc.sourceforge.net |


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WATCH LIVE | State capture: Reverend Frank Chikane takes the stand
by timesliveReverend Frank Chikane, the former Director-General in the Presidency during president Thabo Mbeki's tenure, gives evidence at the state capture commission of inquiry on Tuesday.
Click here for the latest news and analysis of the state capture inquiry
Lord Peter Hain testified at the Zondo commission on Monday.
Hain spoke about global banks being instrumental to state capture in South Africa, by protecting corruption and laundering money for financial criminals such as the controversial Gupta family.
He also argued that banks have a vital role to play in fighting global corruption.


Single-responsibility principle
Let stuff do just one thing really well.
Instead, wrap it in a

and apply the spacing to that.

Don't repeat yourself
Let stuff do just one thing really well.
Instead, wrap it in a

and apply the spacing to that.

Separation of concerns
Let stuff do just one thing really well.
Instead, wrap it in a

and apply the spacing to that.

Immutable
Let stuff do just one thing really well.
Instead, wrap it in a

and apply the spacing to that.


The Dutch Ministry of Justice and Security is responsible to stimulate innovation in the practice of justice and therefore asked the DSS to carry out this 20-week long research project in collaboration with the Oostvaarderskliniek. The project aimed at exploring the needs of the caregivers within the clinic and see where there are opportunities and the potential effects of implementing new technological innovations.
A professional learning community for training and applied science, where learners train for the digital industry. Their aim is to create an inclusive and intelligent digital society, with a human-centered design. They seek to research the impact of technology on society, develop the skills necessary to guide the transformation and pass this knowledge and these skills to a new generation of professionals.
A forensic psychiatric center that practices TBS in Almere. The clinic aims at keeping society safe by providing ex-detainees with mental health treatment and ensures that these patients resocialize in a secure manner. A substantial part of the field research was done with caregivers of the OVK during the autumn of 2019.
The project is working towards four of the UN’s SDGs.
The project was initiated with the team getting acquainted with the topic of TBS and forensic psychiatric care. Desk research was made as well as a visit to the Oostvaarderskliniek in Almere where we could meet caregivers and get an understanding of the facility.
To get a proper understanding of the caregivers’ work at the clinic, we conducted interviews with several caregivers of various professions. This method gave us insights into the caregivers’ motivations and struggles in their everyday work.
Within design methodology ‘cultural probes’ can be used to conduct further and more in-depth research about users. Probing is used as an alternative or addition to traditional methods such as interviews/observations when these methodologies don’t provide you with enough content. Our cultural probes included a journal, sketch cards, emotional documentation for the caregivers to fill out during a 2-week period.
In order to understand the caregivers’ awareness of current and future technologies , we conducted a workshop where this matter was investigated. The caregivers got to engage in discussions regarding the topic and get innovative by creating physical prototypes of their future envisioned technologies.
To dig deeper into the minds of the caregivers, we conducted a workshop where their mindset towards future technologies was investigated. We presented a provocative prototype, or ‘provotype’, that was used as a conversation starter to enable a futuristic vision of the clinic and their work.
We created several speculative narratives that were used to gain more insights from all involved stakeholders. The narratives were presented in the form of three short video narratives and sparked conversations around various controversial topics.
From the design fictions created, we could discuss, analyze and value the topics through a ‘value proposition map’. The method enables the participants to consider the effects of a potential change from a societal, economical, ecological and psychological perspective.
This is the moment to show off the hard work! An exposition hosted by the DSS to show the project to the rest of the learner & visitors.
Project coach
Interaction Designer/Programmer
Systemic designer
Product designer
Business strategist
During the project, we’ve faced some challenges to enhance the result we’ve gathered. So was there limited access to the clinic. The agendas of the participants were often full and resulted in limited participation. This was something that wasn’t really avoidable to get the results we needed.
There were no patients involved in the research. This was due to regulations. Lastly, the process of implementation was not feasible since we had limited time. The result of our research brought us to future scenario’s and a possible future. More info of this can be read in the report.
On the positive side, there was a lot of engagements from the participants. The caregivers were eager to work with us and participate on the sessions we hosted. Furthermore, there is high potential for the clinic and a lot of collaboration from the partners.


| DOSE: |
500 mg |
oral |
DXM |
(capsule) |
[this has been unedited for a reason .. don't get offended or anything from things that might be misspelled. corrections/additions will be in []'s ]
10:00pm
-----
Dosed 2 250mg (precisly mesured with scales) capsules for a total of 500mg of pure dextromethorphan hydrobromide.
10:45
-----
Feeling a nice warmth through my body. Seems to be starting a bit sooner then usual. Feel a slight pressure in my shoulders and arms. Slight pressure in the back of my brain in both hemispheres, similar to LSD. I feel a sort of aura around my back and shoulders, tingly. No motor, auditory or visually enhancements yet. Slight tremor in my joints when I breath in and out deeply almost a shiver but i'm not cold. Mild naseua, expected for this dosage and most dosages with dxm.
11:00 +1
-----
Starting to come on a little stronger now. Nasuea still present slightly intensified (expected). Body getting alot warmer and tingly. Tactile contact feels good. Deep breaths a plesant shiver through my body, similar to the ones you get everyonce in awhile outside on a cold day but much more plesant. Video games are more enjoyable, still no visuals however. Pressure in the back of the brain has slightly diminished in location density. Seems to have traveled farther foward in my brain but is still present in the back.
11:30
-----
Feeling pretty good now. Still no motor control or sensory enhancements. Good mindset, I feel very happy and content with my life. Nausea is still slightly increasing (expected). Pressure is still there which seems to have stayed in the same locations just increased in strength.
11:45
-----
Much more intense effect now. Music sounds very good. I am currently listening to Aphex twin - I Care Because You Do. I find that experimental/ambient are wonderful for dxm trips. Nausea is staying the same amount as before.
12:00am +2
-----
Not much new to report except a slight downward pressure on my entire body beginning to gradually increase. All previous effects still present.
*self notes. Has been 2 hours and it seems to be much less intense then my previous 500mg dosage, lets see how things go.
12:45
-----
Starting to feel the full dxm effects. Slight loss in motor control (legs not doing wut i tell them). Slight loss in balance ability. Focusing eyes on objects 10-15 feet away difficult.
1:00 +3
-----
Greatly involved in my trip, very dissasociated. Loss of motor control, slight CEV's similar to TV 'snow'. Very good 'mindfuck'. Tactile contact enhanced, i enjoy rubbing my hand together and scratching my scalp
*note to self ... dark crystal is a very good movie
1:30
----
tripping really good now, music sounds very clean and precise. good dissassociation good mind opening, difficulty typing (expected) sweaty palms, having a good time chatting on irc. slight loss of balance, extremidites tingly, sweaty armpits. CEVS remenante of previous nintendo game play (grid and scrolling graphics)
2:30
----
had an interestnig trip with jim morrison till he reached the scratched portion ... it seems i have alot of good scratched dicks [supposed to be discs].
*note to self buy new copy of jim morrison - an american prayer and get a new copy of goldie - timeless cd 1
4:00 +6
----
peak intensity starting to wear off, still slighytl dissassociated but comming back to earth. i still have slight problems walking, rubbing my head and face in my pillow feels wonderful. music still feels and sounds great .. starting to think about things, life etc.. having good visuals, i have been sitting in the dark for the past hour or so listening to music ... the best i can describe the visuals as is a haze of snow in my vision. not really like real snow but like tv snow .. alternating miniscule dots of black and white the majority black
*note to self get your fucking [sorry for the language, shows my mood] drivers license
4:45
----
i decided to go watch some tv, still tripping as hard as previously. lethargic walking has turned into a scurry from place to place (aka regaining motor control of extremities). visuals still present
5:00am +7
----
time to goto bed, i'm still tripping but diminished enough for me to fall into REM sleep. i expect lucid, and very visual dreams.
3:00pm morning after
----
seems to have been a very successful trip. i didn't start feeling full effects until almost +3 which is very odd. overall trip intensity was not as great as similar previous doses. this is possibly do to a tolerance buildup from previous trips of the same dosage. i will investigate this further. all in all i am very happy about this trip. it allowed me to play with dxm in some new ways and helped me realize some things in my life that i really need to take care of. just another notch in the 'i love you dxm' board.
Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid.


Frameworks are very powerful!
but.. they come at a cost
Amount of Cost = how you use and depend on frameworks
Showing you how to unleash the power of not just 1 framework, but many!
How that benefits YOU, your team/company/project/customer
Vendor lock-in! (technical debt)
This means:
Your app is tightly coupled to one framework
Hard to switch to a new framework
Hard to move code between apps, on different frameworks
Hmm... what does PPI stand for? Not much, but we can be creative!
It's not a framework
Really, it's a framework delivery engine
It delivers core parts of frameworks to your app
Individually, to the features of your app
An engine that you can load up
A standalone application (or service) with dispatch() for HTTP
Or inside existing application
Step 1: customer tells you what they want (kind of)
Step 2: you choose a framework/toolkit that suits that project
Step 3: you build it
Step 4: customer changes their mind on what they want
Step 5: the tool you chose in the beginning, is no longer the correct one
Step 6: you can't switch because you're locked into that vendor
Step 7: you stick with the tool because it's too difficult to switch to the correct tool
You're not psychic! You cannot predict the future
but, you can prepare for it :-)
Your app code belongs to you, not to your framework.
PPI let's you make framework decisions on a per-feature basis, not per-app
When your features grow / evolve / change
You can change your frameworks with them
Therefore, you're in charge!
Whichever ones make sense for your feature
Feature A (backend cms)
Feature B (frontend)
PPI delivers core parts of frameworks to your app
Individually, to the features of your app
Let's you make framework decisions on a per-feature basis.
Cost is influenced by how you use and rely on them
composer.json:"require": {
"psr/log": "~1.0",
"psr/http-message": "^0.11",
"symfony/config": "~2.7",
"symfony/console": "~2.7",
"symfony/debug": "~2.7",
"symfony/finder": "~2.7",
"symfony/yaml": "~2.7",
"zendframework/zend-eventmanager": "~2.3",
"zendframework/zend-modulemanager": "~2.3",
"zendframework/zend-servicemanager": "~2.3",
"symfony/templating": "~2.7",
"symfony/framework-bundle": "~2.7",
"symfony/http-foundation": "~2.7",
"symfony/http-kernel": "~2.7",
"symfony/routing": "~2.7",
"symfony-cmf/routing": "1.3.0"
}
composer.json:
"require": {
"ppi/framework": "~2.1"
}
You only need to add what you need
Need templating?
composer.json
"ppi/framework": "~2.1",
"ppi/smarty-module": "~1.0",
"ppi/twig-module": "~1.0",
"ppi/mustache-module": "~1.0"
composer.json
"ppi/framework": "~2.1",
"ppi/laravel-routing": "~1.0"
"ppi/aura-routing": "~1.0"
"ppi/symfony-routing": "~1.0"
composer.json
"ppi/framework": "~2.1",
"ppi/symfony-routing": "~1.0"
"ppi/datasource-module": "~1.0", // LaravelDB, Eloquent, Doctrine ..etc
PPI is a PSR-aware framework
PSR-0, PSR-1, PSR-2, PSR-3, PSR-4, PSR-7
PPI/Framework/Http/Request.php
use Psr\Http\Message\RequestInterface;
use Symfony\Component\HttpFoundation\Request as SymfonyHttpRequest;
class Request extends SymfonyHttpRequest implements RequestInterface
{
public function withBody(StreamInterface $body) {
$new = clone $this;
$new->stream = $body;
return $new;
}
}
composer.json:
<?php
namespace Application\Controller;
use PPI\Framework\Module\Controller as BaseController;
use Psr\Http\Message\RequestInterface;
class Mycontroller extends BaseController
{
public function indexAction(RequestInterface $request)
{
if ('POST' === $request->getMethod()) {
// do POST stuff
}
return $this->render('Application:index:index.html.twig');
}
}
We made a routing interoperability layer (Routing PSR?).
If a Routing PSR is created, we get to throw away a lot of code
21st century. Use composer:
Step 1:
$ composer create-project -sdev --no-interaction \
ppi/skeleton-app /var/www/skeleton
and for your convenience:
Step 2
$ vagrant up ppi-lamp
and now...
app/
├── FrameworkRequirements.php
├── check
├── config
│ ├── base
│ │ ├── app.php
│ │ └── datasource.yml
│ ├── dev
│ │ ├── app.php
│ └── prod
│ ├── app.php
├── console
├── init.php
└── views
├── base.html.php
├── base.html.smarty
└── base.html.twig
app.php
<?php
$config = [];
$config['framework'] = [
'templating' => ['engines' => ['php', 'smarty', 'twig')] ,
'skeleton_module' => ['path' => './utils/skeleton_module']
];
$config['datasource'] => [
'connections' = require __DIR__ . '/datasource.php'
];
$config['modules'] = require __DIR__ . 'modules.php';
return $config;
app.yml
imports:
- { resource: datasource.yml }
- { resource: modules.yml }
framework:
templating:
engines: ["php", "smarty", "twig"]
skeleton_module:
path: "./utils/skeleton_module"
monolog:
handlers:
main:
type: stream
path: %app.logs_dir%/%app.environment%.log
level: debug
public/index.php
<?php
require_once 'app/init.php';
// Create and configure the Application
$app = new PPI\Framework\App(array(
'environment' => 'dev',
'debug' => $true,
'rootDir' => realpath(__DIR__.'/../app')
));
$app->loadConfig($app->getEnvironment().'/app.php');
// Just Boot, no HTTP
$app->boot()
// OR: Handle requests
$app->run();
MyModule
|
├── Module.php
├── resources
│ ├── config
│ │ └── config.yml
│ ├── routes
│ │ ├── aura.php
│ │ └── symfony.yml
│ │ └── laravel.php
│ └── views
│ └── index
│ ├── index.html.mustache
│ ├── index.html.php
│ ├── index.html.smarty
│ └── index.html.twig
└── src
├── Services
│ └── DomainClass.php
├── Controller
│ ├── Index.php
Simple and light definitions, using ZF2 ServiceManager component
class Module
{
public function getServiceConfig()
{
return ['factories' => [
'post.manager' => function($sm) {
$helper = new PostManagerModule\Classes\PostManager();
$helper->setPostStorage($sm->get('post.storage'));
return $helper;
},
'post.storage' => function($sm) {
$helper = new PostManagerModule\Storage\Post($sm->get('datasource'));
return $helper;
}
]];
}
}
class Module extends AbstractModule implements ModuleInterface
{
public function getRoutes() {
return $this->loadAuraRoutes(__DIR__ . '/resources/routes/aura.php');
return $this->loadSymfonyRoutes(__DIR__ . '/resources/routes/symfony.yml');
return $this->loadLaravelRoutes(__DIR__ . '/resources/routes/laravel.php');
}
}
Homepage:
pattern: /
defaults: { _controller: "Application:Index:index"}
Downloads:
pattern: /downloads
defaults: { _controller: "Application:Index:downloads"}
DocsIndex:
pattern: /docs/{ver}/{page}.html
defaults: { _controller: "Application:Docs:index", ver: "2.0"}
use PPI\Framework\Router\LaravelRouter;
use Psr\Http\Message\RequestInterface as R;
/**
* @var LaravelRouter $router
*/
$router->get('/', [
'as' => 'Homepage',
'uses' => 'Application\Controller\LaravelExampleController@index'
]);
$router->get('/example', 'Application\Controller\LaravelExampleController@index');
Loading up PPI App in your legacy app
ppi.php
<php
$ppiApp = new PPI\App(['env' => 'prod', 'debug' => false]);
$ppiApp->loadConfig(include 'app.config.php');
$ppiApp->boot();
return $ppiApp;
Wordpress example
wordpress.php
function get_post() {
$postManager = ppi('post.manager');
// .. Do wordpress-y things here
$post = $postManager->read(get_post_id());
}
PPI is ready for you to build projects in.
Release 2.1 is in alpha now and your feedback is welcome.
PPI prepares you for change. It's DESIGNED for change.


mgmt/tm/wam/objectType/extensions
mgmt/tm/wam/objectType/mimeTypes
mgmt/tm/wam/policy/nodes/invalidations
mgmt/tm/wam/policy/nodes/invalidations/cacheContent
mgmt/tm/wam/policy/nodes/invalidations/cacheContent/values
mgmt/tm/wam/policy/nodes/invalidations/request
mgmt/tm/wam/policy/nodes/invalidations/request/values
mgmt/tm/wam/policy/nodes/matching
mgmt/tm/wam/policy/nodes/matching/values
mgmt/tm/wam/policy/nodes/proxy
mgmt/tm/wam/policy/nodes/proxyOverride
mgmt/tm/wam/policy/nodes/proxyOverride/values
mgmt/tm/wam/policy/nodes/proxy/values
mgmt/tm/wam/policy/nodes/substitutions
mgmt/tm/wam/policy/nodes/variation
mgmt/tm/wam/policy/nodes/variation/values
mgmt/tm/wam/resource/concatSet


The quick brown fox jumped over the lazy dog.
The quick brown fox jumped over the lazy dog.
Wow, I love internal CSS!
The quick brown fox jumped over the lazy dog.
Wow, I love internal CSS!
This is some more text. And this text is underlined.
Wow, I love internal CSS!
Margins go clockwise from top: 1/2/3/4
This is some more text. And this text is underlined.
This paragraph is not floated!


Curry brings hot streak to D.C. to face Beal, Wizards
Kia Rookie Ladder: LaMelo Ball shakes up Top 5 as he nears return
Anthony Davis plans to return to lineup vs. Mavs
The All-Star forward had missed 4 consecutive games last week before returning for Sunday's game.
These are the latest scenarios for playoff clinching, seeding and elimination.
The Hornets rookie isn't the only player on the rise with less than one month left in the regular season.
The Warriors' star has scored at least 30 points in each of his last 11 games.
Legenkda
Legenda


"Hello World"
"#current date#"
Currated
Proposals
Good People
Edwin Steinmetz
<EMAIL_ADDRESS>Dwin357 on twitter
Dwin357 on GitHub
ph: ###-###-####
Currated
Proposals
Good People


Battle of Cuautla(1911) - This battle has been described as "six of the most terrible days of battle in the whole Revolution". Emiliano Zapata and his army attacked the town of cuautla where the Golden fifth were stationad. Eventually, the remains of the defending Golden Fifth regiment, the Fifth Cavalry Regiment of the Federal Army, withdrew and Zapata took control of the town. The Zapatista victory convinced Porfirio Díaz to come to terms with Francisco Madero, agree to the Treaty of Ciudad Juárez and resign as president.
Plan of ayala(November 1911)-The Plan of Ayala (Spanish: Plan de Ayala) was a document written by Mexican Revolution leader Emiliano Zapata and his supporters in November of 1911, in response to Francisco I. Madero and his Plan of San Luís. The plan is a denunciation of Madero as well as a manifesto of Zapatismo and what it stood for. It calls for land reform and freedom, and would become very important to Zapata's movement until his assassination in 1919.
Convention of Aguascalientes(1914)-This convention was intended to settle the differences between the "big four" warlords who played the biggest roles in overthrowing Huerta: Pancho Villa, Emiliano Zapata, Venustiano Carranza and Alvaro Obregon. From the onset, however, the Convention was dominated by the Villistas, who imposed their points of view on the other delegates. The supporters of Emiliano Zapata did not arrive until 26 October (a delegation of 26, led by Paulino Martínez and Antonio Díaz Soto y Gama). The Convention declared itself sovereign, elected General Eulalio Gutiérrez Ortiz as President of Republic, and appointed Villa commander of the Conventionalist Army, which then took up arms against Carranza's Constitutionalists. Due to the disagreements that Carranza had with Zapata and Villa, the three refused to attend the convention and little developed as a result. After the meeting, the newly reconciled Villa and Zapata entered Mexico City on 6 December, at the head of an army of 60,000 men. Carranza and his supporters consequently fled to Veracruz.


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--- layout: archive title: Zulip Chat Archive permalink: /stream/113488-general/topic/Cannot.20find.20instance.html ---
In mathlib/data/finsupp.lean
the instance has_add
of finsupp
structure was already proved,
but in t he following example, it failed to synthesize type class instance for has_add
...
Don't understand what instance I missed...
import data.finsupp variables {α : Type*} {β : Type*} [has_zero α] [has_zero β] [add_monoid α] [add_monoid β] variables [decidable_eq α] [decidable_eq β] lemma support_contain_a' (a b : α →₀ β) : a.support ⊆ (a + b).support := sorry
Last updated: Apr 24 2020 at 19:02 UTC


Please fill in this form to be added to the mailing list.
Posted by Katerina Plushko on April 1, 2019


ButtonMerchant
ButtonMerchant
is the main entry point to the library.
To get started with your integration, get your application Id from from the Button Dashboard. and follow our simple integration guide
-
The last tracked
attributionToken
from an inbound Button attributed URL.Attention
> For attribution to work correctly, you must:- Always access this token directly—never cache it.
- Never manage the lifecycle of this token—Button manages the token validity window server-side.
- Always include this value when reporting orders to your order API
-
Configures ButtonMerchant with your application Id.
-
Checks the passed URL for a Button attribution and if present stores the token.
Attention
Attention:
To correctly attribute customers, you must call this method with every incoming
url
anduserActivity
from the followingUIApplicationDelegate
methods:application(_:open:options:)
application(_:userActivity:restorationHandler:)
-
Checks the URL in the passed NSUserActivity for a Button attribution and if present stores the token.
Attention
Attention:
To correctly attribute customers, you must call this method with every incoming
userActivity
from the followingUIApplicationDelegate
method:application(_:userActivity:restorationHandler:)
-
Checks to see if the user visited a url prior to installing your app.
If a url is found, your completion handler will be called with the url and you are responsible for navigating the user to the relevant content in your app. If a url is not found or an error occurs, your completion handler will be called without a url and you can continue with your normal launch sequence.
Attention
Attention:
This method checks for a post-install url exactly one time after a user has installed your app. Subsequent calls will result in your completion handler being called without a url. You do not need to wait for the completion handler before continuing with your normal launch sequence but you should be prepared to handle a post-install url if one is found. All subsequent incoming urls will be routed to your
UIApplicationDelegate
as usual. -
Reports an order to Button.
See also: Reporting Orders to Button (docs)
-
Discards the current session and all persisted data.
-
An interface through which library features can be enabled/disabled.
-
An interface through which user activity can be reported.


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Mammudeck is a TweetDeck-like columnar interface to Mastodon/Pleroma. It is a work in progress.
Wikipedia says that "Mastodons... are any species of extinct proboscideans in the genus Mammut (family Mammutidae), distantly related to elephants..." I removed the ending "t" from "Mammut" and added "deck" to get "Mammudeck".
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Joe Gomez left with scratch below right eye after Raheem Sterling row in St George's Park canteen
England trained at St George's Park on Tuesday after the row between Raheem Sterling and Joe Gomez which has seen Sterling dropped from the squad
by John Cross, James Whaling, https://www.facebook.com/johncrossmirror/, https://www.mirror.co.uk/authors/james-whaling/Joe Gomez trained at St George’s Park today sporting a scratch below his right eye.
Liverpool defender Gomez appeared to have a small mark from his bust-up with Raheem Sterling on Monday.
But Sterling also trained this morning despite Gareth Southgate deciding to make him unavailable for Thursday’s game with Montenegro after the row.
Both sides have played down the physical side of the row and they have made peace with Gomez believed to have urged Southgate not to send Sterling home.
Sterling and Southgate initially clashed during Liverpool's victory over Manchester City at Anfield on Sunday.
The players were involved in a heated exchange towards the end of the game, but embraced after the full-time whistle.
But emotions were still running high when the duo joined up for England duty at St George's Park on Monday.
Sterling reacted badly as Gomez offered a handshake from behind leading to a verbal altercation between them.
Some England stars stepped in to separate the duo after realising the incident was not friendly banter as initially thought.
Sterling moved to play down the altercation having been stood down from duty for the Montenegro clash, appearing the situation has been defused.
He wrote on his Instagram account: "First and foremost everyone knows what that game means to me! Everyone knows that I am not that way inclined and more to the point. Both Joe and I have had words and figured things out and moved on.
"We are in a sport where emotions run high and I am man enough to admit when emotions got the better of me.
Sterling added that he and Gomez "are good" and "both understand it was a 5-10 second thing it's done we move forward and not make this bigger than it is.
"Let's focus on our game on Thursday," he signed off, alongside three love heart emojis.