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Marcus Pavilonis
8/4/2018
Daniel Torres found a family in his church of the Seventh-day Adventists.
Although he grew up Catholic, he went with his aunt to an adventist church in Puerto Rico and was baptized at 11 or 12 years old. He found kinship with the church. Then, he sent the church a special letter when he was a sophomore in college in 1982, telling them who he was. The church read the letter during a ceremony and dismembered him. Another member of the church told him he wasn’t welcome back.
“It was hard,” Torres, a professor of Spanish, said. “I grew up in that church all the way to my college years. I lost that whole family, a whole group of people. A lot of friends that rejected who I was.”
Some Athens residents who identify as LGBTQ have found support in their religions, while some think, for them, not being religious has helped them rekindle relationships with their families.
Torres left the Seventh-day Adventist church and moved to New York and then to Cincinnati.
“I grew out of it and you know, you go through the period where you’re mad at God and you kind of want to understand why you’re not being loved for who you are, especially from an institution that is important as a church,” Torres said.
Torres eventually rekindled his relationship with God, but with the religion he grew up in as a small child — Catholicism. He liked that there was a sense of anonymity in the church, where one could go and worship without anybody knowing who they are.
In Columbus, he found a Catholic men’s support group that was open with gay people, and he led study abroad trips to Yucatan, Mexico, where he connected with a Catholic church there. Within the last 15 years, Torres has found a place in the Catholic church. Although he doesn’t consider himself a perfect Catholic, he attends mass once a week and every year reads the entire Bible.
Marcus Pavalonis | ILLUSTRATION
“I’m comfortable with who I am,” Torres said. “I am happy that I came out when I did. I always tell my story to encourage people to do the same because it does get better. That’s how it goes. You get a lot of opposition at first, you have a lot of fear. But I think everything kind of falls into place. That’s how things happen in life over all.”
Leandro Hernandez, a graduate student studying Spanish, said that he never grew up with a religion, but when he came out to his father, he was shocked. He remained silent for two years, but the lack of religion in the household helped Hernandez rebuild a relationship with his father.
“I’m really close with my father now because he’s not religious,” Hernandez said. “I didn’t have any idea of sin or hell or anything that I sometimes hear. Nobody punished me. I was so lucky. Mine is a happy story, and I think part of that was because we were not religious.”
When Jan Griesinger first told her father that she liked women, he did not like it.
“When I moved here, I realized the person I wanted to be with was a woman friend,” Griesinger said.  Eventually he figured it out. I’m sure I said this important woman in my life.”
Griesinger, originally from Chicago, went to a seminary in Dayton and was later ordained as a minister. She worked at Wright State University before she started working as the director of OU’s United Campus Ministry in 1967.
“Part of the good thing was that United Church of Christ had already some openly LGBT pastors,” Griesinger said. “Somebody had come out, maybe as early 1967, and was kept ordained, kept as a minister. Almost any other denomination wouldn’t have worked.”
As Griesinger’s denomination is within the United Church of Christ, there is no church in Athens connected to it, so she goes to a church in Marietta. But she would often sit in at other churches. Before she retired in 2004, Griesinger’s United Campus Ministry housed the OU Gay and Lesbian Association.
“It helps if they find a church or a community that is supportive. In Athens, I think that you would find several churches, like Presbyterian, Episcopal, First United Methodist,” Griesinger said. “If a person finds either an individual support group or a religious community, they’ll feel a lot more together.”
Torres suggested that family is most important, especially if somebody who identifies as LGBTQ was rejected by their religious community.
“Don’t believe in that hatred,” Torres said.  You have to help them understand who you are. If you still find resistance with your family, give it time. Because you are their baby, and they love you no matter what.”
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Palace Ultimo 2019 Tracksuits
Filled with Winter-ready fabrics & cozy fits.
by Jack StanleyPalace has revealed its full range of tracksuits for the Ultimo 2019 collection, with weather-ready items coming in GORE-TEX and Polartec featuring in the range. The stand-out tracksuit in the capsule is the Polartec Lazer set, which is releasing in a range of colors spanning from muted “Cobalt Blue” to the more eye-catching “Hi Vis Yellow” and “Hi Vis Pink.” Additionally, the set will release in three different camouflage options, referencing a theme that runs throughout the collection.
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A DANGEROUS GAME A film review by Lons Ponschock Copyright 1995 Lons Ponschock
Directed by Abel Ferrara Stars Harvey Kietel, Madonna, James Russo
I noticed something about this film in the first five minutes: It uses the 'c' word. I heard the 'c' word once before in CLEAN AND SOBER. Hearing the 'c' word is pretty rare these days, both in film and ... well in real life too.
Using the 'c' word is 'a dangerous game' all it's own.
Ask me. :-)
Another dangerous game is trying to do verite style film like John Cassavetes when you are not John Cassavetes. This is the game that Abel (BAD LIEUTENANT) Ferrara plays in his film.
The film within the film with stronger language than Cassavetes usually deals with is simply a meller. Madonna (DICK TRACY, BODY OF EVIDENCE) plays opposite James Russo: a Bruce Willis look and sound-alike in a a film directed by Harvey (THE PIANO) Kietel. Ever notice that in this format the film credits look like nicknames? There's probably an idea there too. :-)
The film within builds to something like fever pitch. But in doing this Mr. Bruce Willis-alike sounds more and more like a 90's version of Stanley Kowolski. It is a picture of the gone world, a style where the realities of performance and the pressures are handled in manner not unlike shooting an x-vid. The booze and the drugs are real. The emotional content of the scene is produced from it's chemical supports.
Kietel and Madonna took a plenty big chance, I think in playing this dangerous game. Do not be mistaken that the actual film content has real drugs in it though. This is one of the plot lines-- kind of like SIX CHARACTERS IN SEARCH OF AN AUTHOR (the play by Luigi Pirandello from which this play within style was taken) meets THE LOWER DEPTHS (by Gorki, another play in the classic literature.) But this is a facile analogy ... there are serious problems with A DANGEROUS GAME.
A DANGEROUS GAME may attain cult status some day for so- called "film buffs." Something the Slackers can talk about endlessly.
So, while trying to justify the time spent with this film, I have to say that it will have limited appeal. Those like myself who want to follow the work of Abel (BAD LIEUTENANT) Ferrara should get it when it turns into basic stock on the dollar rack ... which will likely be very soon.
-- lon
The review above was posted to the
rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).
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review and has no editorial control. Unless stated otherwise, the copyright
belongs to the author.
Please direct comments/criticisms of the review to relevant newsgroups.
Broken URLs inthe reviews are the responsibility of the author.
The formatting of the review is likely to differ from the original due
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Related links: index of all rec.arts.movies.reviews reviews


{%load static%}
Smyle Mouse is a service to control computer
using Face and Voice.
Give control of mouse to the application by opening the mouth.
Control the mouse movements by moving the face to left and right.
Blink Left Eye for left click and Right Eye for right click of the mouse.
Control mouse movements by speaking like : Move Right 40
Scroll mouse by speaking like : Scroll Up 400
Control mouse Clicking by speaking like : Left Click
Control keyboard typing by speaking like : Type this Google
Control keyboard letter typing by speaking like : Press key A
To Hold/Release the key speak like : Hold/Release delete
Instruction to move the cursor in horizontal direction is : (move left/right percentage of screen width )
Instruction to move the cursor in vertical direction is : (move up/down percentage of screen height )
P:<PHONE_NUMBER>


List all Reports for an Institute or Center for a particular year
All Annual Reports for NIMH for reporting year 2012
119 Annual Reports
Investigator-Initiated Project
1.
MH000274 (2012) Methods In Mass Spectrometry
Sanford P. Markey, PhD
Mass spectrometric methods for the analysis of protein structures are being improved, applied and tested in independent and collaborative research projects in proteomics. Projects in separation methods and data processing are in progress. In the past year, progress has been made on implementation of ...
2.
MH000279 (2012) Proteomics in neurotoxicology
Sanford P. Markey, PhD
We are applying proteomic methodology to unresolved problems in neuropathologic diseases. Progress continues in studies on the structure of the postsynaptic density and its remodeling by drugs used in the treatment of mood disorders, on protein complexes implicated by genomic studies of schizophreni ...
3.
MH000332 (2012) Genetic Animal Models for the Study of Serotonin Function and Behavior
Dennis L Murphy, MD
As recently reviewed by us, SERT-deficient +/- and -/- mice have gene-proportionate increases in extracellular fluid serotonin concentrations, i.e., 3- or 6-fold excesses respectively over wildtype +/+ mice. At the same time, SERT -/- mice have a marked deficit of intracellular, releasable serotonin ...
4.
MH000336 (2012) The Genetics Of Obsessive Compulsive Disorder
Dennis L Murphy, MD
OCD is a severe, heritable condition with a lifetime prevalence of about two percent in world populations. The mode of inheritance is incompletely understood but is likely complex, involving multiple genetic loci of small to moderate effect. Our laboratory has played a leading role in studies of OCD ...
5.
MH000478 (2012) Neural Mechanisms of Learning and Memory in Vision
Mortimer Mishkin, PhD
The essential circuit for both item and associative stimulus recognition in any given sensory modality consists of the relevant cortical sensory processing stream(s), the medial temporal periallocortex (i.e. posterior parahippocampal, perirhinal, and entorhinal cortices), the ventromedial prefrontal ...
6.
MH000889 (2012) Dysregulation of Protein Synthesis in Fragile X Syndrome
Carolyn E Beebe, PhD
During the 2012 funding period, we addressed the following:
We measured rCPS in 15 male subjects (18-24 y) with the full fragile X mutation and 12 age-matched healthy volunteers. Because of their impairments it was necessary to study FXS subjects under deep sedation. We used propofol as the sedatin ...
7.
MH001090 (2012) Studies Of Central Nervous System Functional Anatomy
Miles Herkenham, PhD
Our work currently falls into three major but related areas. The first area is focused on the study in mice of central determinants of psychosocial stress-induced depressive-like behaviors and the amelioration or prevention of these behavioral states by environmental enrichment with voluntary wheel ...
8.
MH001101 (2012) Neural Mechanisms of Learning and Memory in Audition
Mortimer Mishkin, PhD
Our neurobiological findings in monkeys have raised the possibility that, like occipitotemporal visual areas, superior temporal auditory areas send highly processed stimulus quality information to downstream targets via a multisynaptic corticocortical pathway. Previous evidence indicated that the au ...
9.
MH002032 (2012) Neural Coding Of Visual Stimuli
Barry J Richmond, MD
Two primary processes that are critical for normal higher level visual performance are the ability to distinguish one from another while recognizing that that the items are similar, e.g. distinguishing 2 cats is different than distinguishing cats and dogs irrespective of which cat or dog and, second ...
10.
MH002035 (2012) Functional Anatomy Of Perceptual and Attentional Systems in the Primate Brain
Leslie G Ungerleider, PhD
A typical scene contains many different objects that compete for neural representation due to the limited processing capacity of the visual system. At the neural level, competition among multiple stimuli is evidenced by the mutual suppression of their visually evoked responses and occurs most strong ...
11.
MH002039 (2012) Pharmacology Of Stimulus Memory And Habit Formation
Mortimer Mishkin, PhD
The importance of the cholinergic system in memory function was first recognized because the memory impairment characteristic of Alzheimers disease was associated with the loss of large cholinergic neurons of the basal forebrain and pathophysiology of the entorhinal/perirhinal, or rhinal cortex. We ...
12.
MH002179 (2012) Animal Models Of Neuropsychiatric Disorders
Jacqueline N Crawley, PhD
Autism is a neurodevelopmental disorder that affects approximately 1% of the U.S. population. The causes of autism spectrum disorders are under intense investigation, with strong evidence for genetic substrates. Lifetime costs of caring for autistic individuals are high, both in terms of a) qualit ...
13.
MH002228 (2012) Genetic Neurobiology Of Drosophila
David John Sandstrom, PhD
We have established that sensitivity to volatile anesthetics is strongly altered by mutations in two ion channel genes, narrow abdomen (na) and the ryanodine receptor (Ryr).
The na gene encodes an unusual homolog of voltage-gated sodium and calcium channels that is expressed broadly in the cent ...
14.
MH002344 (2012) Neuropsychiatric Disorders--protein Structure/activity Studies
Brian M Martin, PhD; Sanford P. Markey, PhD
The unambiguous identification of proteins/peptides is crucial for the definition of the proteome. Using ProteinChip Array technology (SELDI) we have developed experimental protocols and probed test conditions required for protein identification on ProteinChip Arrays. We are able to directly digest ...
15.
MH002386 (2012) Chemical Coding Of Neurotransmission
Lee E Eiden, PhD
The neuropeptide slow transmitter PACAP (pituitary adenylate cyclase activating polypeptide) is released at synapses that transduce stress responses to the brain, and mediate homeostatic adjustments to stress by the organism. Allostatic responses to systemic and psychogenic stressors at multiple poi ...
16.
MH002399 (2012) Postmortem Brain Tissue Examination in Neuropsychiatric Disorders
Joel Kleinman, MD, PhD
We have conducted several investigations using postmortem human brain specimens focused primarily on understanding the pathophysiology of SZ in addition to other complex neuropsychiatric disorders. In addition to our own studies, the Section continues to provide postmortem human brain tissues to re ...
17.
MH002468 (2012) Mechanisms Of Action Of Psychoactive Drugs
De Maw Chuang, PhD
We investigated the hypothesis that glycogen synthase kinase-3 (GSK-3) and histone deacetylases (HDACs) are initial targets of lithium and valproic acid (VPA), respectively, that trigger diverse neurobiological events including neuroprotective and neurotrophic effects, anti-inflammatory effects, a ...
18.
MH002497 (2012) Functional Organization Of The Basal Ganglia
Charles R Gerfen, PhD
Further work on the cellular mechanisms underlying neurologic and pscyhiatric disorders is limited by the fact that neurons throughout the brain utilize common mechanisms for critical functions such as synaptic plasticity, whereas specific neural systems are affected in different disorders. A large ...
19.
MH002498 (2012) Roles of Oxytocin and Vasopressin in Brain
Walter Scott Young, MD, PhD
--We have continued this fiscal year to study our gene knockouts (KO) of the mouse oxytocin (Oxt) and vasopressin (Avp) 1a and 1b receptors (Oxtr, Avpr1a and Avpr1b, respectively) to investigate their specific roles in mediating behavior. We are also continuing to analyze whether we were successful ...
20.
MH002537 (2012) Psychobiology And Treatment Of Perimenopausal Mood Disorders
Peter J Schmidt, MD
A role of estradiol withdrawal in the onset of mood disorders in some perimenopausal women has been suggested indirectly by the clustering of depressive episodes during the late menopause transition (the stage of ovarian aging associated with maximal decline of ovarian estradiol secretion) and by es ...
21.
MH002581 (2012) Childhood Onset Schizophrenia
Judith L Rapoport, MD
In comparison with adult patients, childhood onset patients have a greater number of prepsychotic developmental disorders. One third have earlier forms of autism spectrum disorder, and one third have motor, speech, language, attentional or impulse related developmental disorders (Rapoport et al. 200 ...
22.
MH002585 (2012) Role of Neuroendocrine Stress Response in Inflammatory and Behavioral Illness.
Esther M Sternberg, MD
PROJECT I. Sweat Patch Biomarkers: Clinical Studies. This is currently the main focus of the SNIB. We previously showed that neural and immune biomarkers are detectable in sweat and strongly correlate with plasma levels in a group of women with major depressive disorder (MDD) in clinical remission ( ...
23.
MH002588 (2012) The Neural Foundations for Memory and Social Cognition In The Human Brain
Alex Martin, PhD
This past year we have continued to focus on a major part of long-term memory, termed semantic memory, that is composed of general information, such as facts, ideas, and the meaning of objects and words. We are particularly interested in characterizing the neural substrate mediating object and word ...
24.
MH002592 (2012) Viral And Cellular Factors Governing Efficient Gene Delivery
Maribeth V Eiden, PhD
The Section on Directed Gene Delivery assesses the ability of retroviral vectors to deliver efficiently deliver genes to appropriate target cells with the end goal of transferring therapeutic genes to cells of the central nervous system. We and others have determined that although Adeno-Associated V ...
25.
MH002619 (2012) Neural Mechanisms Of Motivation And Reward
Barry J Richmond, MD
Selectively attending to or associating positive reinforcement with a given stimulus yield similar effects on behavioral performance. Subjects show improved accuracy and shorter reaction times when asked to detect changes in stimuli at attended versus unattended locations or when given larger reward ...
26.
MH002652 (2012) Imaging of Neuropsychiatric Disorders with Developmental and Genetic Mechanisms
Karen F Berman, MD
The Section on Integrative Neuroimaging continues to make advances toward its goals of understanding the nature, molecular underpinnings, underlying neurochemistry, and clinical correlates of neural systems-level dysfunction in schizophrenia. This year, we have made substantial progress in furtheri ...
27.
MH002666 (2012) Evaluation and Treatment of Obsessive Compulsive and Related Disorders
Susan Elizabeth Swedo, MD
Obsessive-compulsive disorder (OCD) affects 1-2% of children and adolescents, causing significant distress and impairments from the unrelenting obsessional thoughts and compulsive behaviors. In some cases, childhood-onset OCD appears to arise as a consequence of common childhood infections, in ...
28.
MH002685 (2012) Peptide Receptor Systems
Theodore B Usdin, MD, PhD
Summary:A current focus of the laboratory is investigation of the physiological functions of the neuropeptide Tuberoinfundibular Peptide of 39 residues (TIP39) and its receptor, the Parathyroid Hormone 2 (PTH2) receptor. These molecules were discovered in this laboratory several years ago. In previo ...
29.
MH002712 (2012) Characterization Of Neuropsychological Impairment In Schizophrenia
Karen F Berman, MD
Current and recent work generally has focused on understanding and improving cognitive and behavioral phenotypes and applying these in analyses of whole genome association data.
In Dickinson et al (2011) we extended earlier analyses of cognitive structure in schizophrenia cases and controls (Dick ...
30.
MH002716 (2012) MRI Studies of Brain Function and Metabolism
Karen F Berman, MD
The group has continued to make strides conducting imaging-genetic studies to explore basic molecular biology and genetics of human information processing in healthy controls and patients with schizophrenia. Interesting findings have emerged from these studies.
1) Using fMRI during working memory, ...
31.
MH002717 (2012) Neuroimaging of Brain Circuits and Neurogenetic Mechanisms in Normal Cognition
Karen F Berman, MD
In the service of its core scientific agenda, the Section on Integrative Neuroimaging (SoIN) has continued its long-standing commitment to characterizing the neurochemical, neurogenetic, and neuropsychological contributions to neural systems relevant to mental illness. The Section has made particul ...
32.
MH002734 (2012) Genetic Basis Of Cortical Malfunction In Schizophrenia
Karen F Berman, MD
Our continued exploration of genes that impair cortical function and increase risk for developing schizophrenia (SZ) has led us to further interrogate the brain-specific KCNH2 3.1 isoform first described in Huffaker et al (Nat Med 2009). SZ is a complex psychiatric illness. Dopamine (DA), a neurotra ...
33.
MH002736 (2012) Neural Substrates Of Stimulus Recognition And Association Memory
Elisabeth Adams Murray, PhD
The prevailing model of conscious memory holds that a group of loosely related structures, collectively called the medial temporal lobe (MTL), work together as a single functional unit. According to this current orthodoxy, the structures in the MTL are thought to store the memory of specific objects ...
34.
MH002762 (2012) Mechanistic studies on stress, brain inflammation and neuroprotection
Juan M. Saavedra, MD
Our first specific aim is to clarify the mechanisms involved in the beneficial effects of compounds which have not, until very recently, been considered of interest to the therapy of brain disorders. The second specific aim is to further establish the extent of therapeutic benefits of such compounds ...
35.
MH002768 (2012) Subcellular Compartmentilization of Neuronal Gene Expression
Barry Bernard Kaplan, PhD
Axons and nerve terminals are unique subcellular structures of the neuron that play a critical role in the development and maintenance of neural connectivity. One of the central tenets in neuroscience is that the protein constituents of these distal neuronal compartments are synthesized in the nerve ...
36.
MH002778 (2012) The Phenomenology And Neurophysiology Of Juvenile Bipolar Disorder
Ellen Leibenluft, MD
Since the beginning of this project we have screened over 1300 subjects for this study. We have enrolled approximately 180 youth with bipolar disorder (BD), 240 subjects at risk for BD because they have a parent or sibling with the illness, and 100 adults with BD. This year, approximately 20 new sub ...
37.
MH002781 (2012) fMRI Studies Of Pediatric Mood And Anxiety Disorders
Daniel Pine, MD
Through a series of three protocols, we are using functional magnetic resonance imaging (fMRI) to examine neurocognitive correlates of pediatric anxiety disorders. Through ongoing collaborative studies, we also have increasingly compared findings in these syndromes with findings in adult anxiety di ...
38.
MH002782 (2012) Fmri Studies Of Risk For Mood And Anxiety Disorders In Children
Daniel Pine, MD
In this project, our group is examining biological aspects of risk for mood and anxiety disorders in children. Such work has major public impact. By identifying biological risks in children, information on novel treatments and preventative interventions will emerge. Given the understanding of mos ...
39.
MH002783 (2012) Functional MRI Method Development
Peter A Bandettini, BS, PhD
The Section on Functional Imaging Methods (SFIM) continues to develop cutting edge methods at the interface of functional MRI (fMRI) technology, image processing, interpretation of the signal, and neuroscience applications. The goal of SFIM is to fill the much-needed gap of improving fMRI from both ...
40.
MH002784 (2012) Neurogenesis in the Adult Brain
Heather A Cameron, PhD
We study the regulation and function of adult neurogenesis in rats and mice, which show continued production of new neurons throughout adulthood similar to that in primates, including humans. During the past year, we completed a study examining the activation of young neurons in adult mice by spatia ...
41.
MH002786 (2012) The Pathophysiology and Treatment Of Children With Severe Mood Dysregulation
Ellen Leibenluft, MD
As noted above, in response to the concern about the appropriate diagnosis for children with chronic, severe irritability, we defined a group of children whom we described as having severe mood dysregulation (SMD). These children have extremely severe irritability and symptoms of hyperarousal (the l ...
42.
MH002793 (2012) PET Radiopharmaceutical Sciences
Victor W Pike, PhD
The Molecular Imaging Branch (MIB) aims to exploit positron emission tomography (PET) as a radiotracer imaging technique for investigating neuropsychiatric disorders, such as autism, depression, addiction, schizophrenia and Alzheimer's disease. Fundamental to the mission of the MIB is the developmen ...
43.
MH002794 (2012) Pediatric Brain Imaging
Jay Giedd, MD
A unifying theme emerging from our work is that in neuroimaging, as in life, the journey is often as important as the destination. Trajectories of brain morphometry, as opposed to snapshots in time, are more highly correlated with cognitive parameters, are better predictors of clinical outcome, and ...
44.
MH002795 (2012) Preclinical Evaluation Of PET Radiotracers
Robert Innis, MD
Examples of progress made during the prior year are summarized below.
1) In an important study, we demonstrated that the function of permeability glycoprotein (P-gp) could be selectively measured using a combination of tariquidar (a P-gp inhibitor) and the radiotracer 11C-N-desmethyl-loperamide ( ...
45.
MH002797 (2012) Neuronal avalanches in the neocortex
Dietmar Plenz, PhD
1. Neuronal avalanches are increasingly recognized to be important for cortex function. Given the 200+ related articles that have been published since our first report on neuronal avalanches, the field has been readied itself for its first major conference. My Section took the lead in organizing t ...
46.
MH002798 (2012) The Psychophysiology Of Fear And Anxiety
Christian Grillon, PhD
Our objective is to determine the extent to which various aspects of defense mechanisms and conditioned fear are relevant to features of particular forms of normal and abnormal anxiety in humans using a translational approach. Past works focused mainly on the mechanisms underlying the expression of ...
47.
MH002800 (2012) Identifying Neural Substrates of Behavior in Drosophila Melanogaster
Benjamin H White, PhD
The goal of this research is to define and characterize the neural networks governing two sequentially-linked behavioral programs in the fly. The first is an adaptive, environmentally-sensitive program that mediates the search for safe surroundings, and the second is a hormonally-driven program that ...
48.
MH002803 (2012) Magnetic Resonance Spectroscopy and Imaging Studies of Brain Functions
Jun Shen, PhD
The goals of this research are to develop advanced magnetic resonance spectroscopy (MRS) and imaging techniques and to apply them and other complementary methods to studying brain metabolism, neurotransmission and enzyme activity. MRS allows measurement of neurotransmission of glutamate and GABA in ...
49.
MH002804 (2012) Family Study of Affective and Anxiety Spectrum Disorders
Kathleen R Merikangas, PhD
The major aims of this project have been accomplished through establishment of a large community based family study of adult probands who participate in comprehensive clinical and biologic assessments followed by comparable evaluations of their adult and child relatives. Recruitment of probands and ...
50.
MH002806 (2012) National Comorbidity Survey - Replication (NCS-R)
Kathleen R Merikangas, PhD
During the past year, we have investigated the structure of depression observed in adults (NCS-R) and adolescents (NCS-A) and found highly similar classes and probabilities across adults and youth, with greater complexity in structure among adults than in adolescents. The subtypes identified in the ...
51.
MH002807 (2012) Zurich Cohort Study of Young Adults
Kathleen R Merikangas, PhD
During the past year, we have continued to analyze the data from this prospective cohort study that covers a total observation period of 30 years for this cohort of young adults who have been followed since the age of 18.
We examined the specific patterns of comorbidity by headache subtype, and t ...
52.
MH002808 (2012) National Comorbidity Survey - Adolescent (NCS-A)
Kathleen R Merikangas, PhD
During the past year, we have devoted substantial efforts to investigate a wide range of mental health topics focusing on anxiety, mood, sleep and substance use disorders and psychotropic medication use in adolescents. Several active NCS-A work groups have continued to work with experts in the fiel ...
53.
MH002810 (2012) Mapping genes that contribute to bipolar disorder
Francis Joseph McMahon, MD
The long-term objective of this study is to identify genes involved in the risk of bipolar disorder
Starting in 1993, in collaboration with 10 academic centers across the United States, we recruited a large sample of over 3,000 individuals with BD or related mood disorders. This is the largest sa ...
54.
MH002813 (2012) Cholinergic Modulation of Cognition and Emotion in Mood Disorders
Maura L Furey, PhD; Carlos Alberto Zarate, MD
Clinical Studies:The role of cholinergic system in mood disorders has been highlighted recently through our demonstration that blocking cholinergic muscarinic activity with scopolamine produces rapid antidepressant effects. Our early studies identified an antidepressant effect of scopolamine in both ...
55.
MH002826 (2012) Control of Fear/Defensive Behavior by Brain Derived Neurotrophic Factor
Alexei Y Morozov, PhD
The main goal of this project is to understand how changes in the hippocampus may cause pathological aggression and antisocial behaviors. We have previously found that mice with the conditional knockout (KO) of Brain Derived Neurotrophic Factor (BDNF) restricted to the hippocampal area CA3 are more ...
56.
MH002828 (2012) Efficacy of an Antiglutamatergic Agents in Treament-Resistant Deprepression
Carlos Alberto Zarate, MD
Novel targets for developing new treatments for treatment-resistant major depression are urgently needed. The glutamatergic system stands as an important to target to pursue in the developing improved treatments for mood disorders. In previous work, we found that the glutamate modulating agent riluz ...
57.
MH002832 (2012) Role of adult neurogenesis in regulation of the HPA axis and stress resiliency
Miles Herkenham, PhD
The hippocampus is a cortical brain structure that has received much attention because it shows structural and functional pathology in a variety of mental disorders. For example, depression, schizophrenia and post-traumatic stress disorder (PTSD) have been correlated with decreased hippocampal ...
58.
MH002835 (2012) Neuronal-Glial Interaction in the Treatment of Bipolar Disorder
Miles Herkenham, PhD
Pro-inflammatory cytokines such as TNFalpha, IL-1, and IL-6, were first studied in the context of cellular responses in the immune system. Studies on the role of cytokines in the brain suggested that their expression and activity are induced in response to an infection, trauma, stroke, or neurodege ...
59.
MH002838 (2012) Neurophysiology of Visual Perception
David A Leopold, PhD
It may be surprising to learn that the human cerebral cortex has more than 50 distinct areas that are devoted to the analysis of visual signals. Why so many areas needed to interpret the retinal image? One answer to this question is that vision is, by its nature, an interpretive process -- a much ...
60.
MH002843 (2012) Genetic Linkage and Association in Bipolar Disorder
Francis Joseph McMahon, MD
This collaboration has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically-based hypotheses about the genetic heterogeneity of the illness. We have ascertained and assessed about 150 nuclear families with a bipolar I proband and two or more sibl ...
61.
MH002844 (2012) Genetic Determinants of Antidepressant Response
Francis Joseph McMahon, MD
Strong evidence from family and twin studies demonstrates that major depressive disorder (MDD) is heritable, yet there has been limited progress in identifying the actual genes involved. A separate, perhaps overlapping set of genes is expected to play a role in individual variation in treatment resp ...
62.
MH002851 (2012) Generalized Anxiety Disorder and Social Anxiety Disorder:
Robert James Richard Blair, PhD
There are three important strands to our work with patients with GSP and GAD:
The first of these strands is determining the degree to which the pathology seen in GAD differs from that seen in GSP. In previous work, we were the first to demonstrate that patients with GSP and GAD differ in their re ...
63.
MH002852 (2012) Clinical Evaluation of PET Radiotracers
Robert Innis, MD
Examples of progress made during the prior year are summarized below.
1) We used the novel radioligand 11C-PBR28 to determine whether in vivo expression of translocator protein (TSPO), an inflammatory marker, is increased ipsilateral to the seizure focus in patients with temporal lobe epilepsy an ...
64.
MH002857 (2012) Glutamatergic Modulators for Rapid & Sustained Antidepressant Effect
Carlos Alberto Zarate, MD
Our research suggests that the glutamatergic system is involved in the mechanism of action of antidepressants. We found that the non-competitive NMDA antagonist (ketamine) resulted in rapid, robust and relatively sustained antidepressant and antisuicidal effects. Response with ketamine occurred with ...
65.
MH002860 (2012) Emotional dysfunction and childhood behavioral disturbance
Robert James Richard Blair, PhD
This project has established a series of core neuro-biological findings regarding the basis of Conduct Disorder (CD), particularly CD with Callous-Unemotional traits (reduced guilt and empathy). Over the past year, our main achievements have been the following:
First, in earlier work on this pro ...
66.
MH002862 (2012) The role of serotonin in emotional processing
Robert James Richard Blair, PhD
Our work thus far has investigated the effects of altering serotonergic systems in humans using acute tryptophan depletion on behavioral performance during emotional processing tasks. Moreover, we have begun to determine how acute tryptophan depletions effects on emotional processing vary as a func ...
67.
MH002863 (2012) Multimodal Neuroimaging of Gene-Brain Relationships in Williams Syndrome
Karen F Berman, MD
The Section on Integrative Neuroimaging has made substantial progress toward elucidating specific genetic contributions to brain structure and function through multimodal neuroimaging studies of Williams Syndrome (WS) individuals and carefully matched comparison volunteers. As discussed extensively ...
68.
MH002865 (2012) Reproductive Endocrine Related Mood Disorders-Differential Sensitivity
Peter J Schmidt, MD
In our earlier studies we have developed experimental models for the triggering of symptoms in both premenstrual dysphoric disorder (PMD) and postpartum depression that we continue to employ in our efforts to identify both the underlying biology of these conditions as well as the development of new ...
69.
MH002868 (2012) Clinical and Behavioral Phenotyping of Autism and Related Disorders
Susan Elizabeth Swedo, MD
Autism is currently defined as a single disorder characterized by impairments in communication and social interaction and the presence of restricted interests and repetitive behaviors. However, there is mounting evidence that autism represents a collection of overlapping neurodevelopmental dis ...
70.
MH002869 (2012) Characterization of Dentate Mossy Cell-restricted Genetic Manipulation Mice
Kazutoshi Nakazawa, MD, PhD
Earlier, we generated a conditional transgenic mouse line in which diphtheria toxin receptor was selectively expressed in mossy cells using the Cre/loxP system. Within one week after diphtheria toxin injection, we observed 80% loss of mossy cells throughout the longitudinal axis. We found no obvio ...
71.
MH002870 (2012) National Health And Nutrition Examination Survey (NHANES)
Kathleen R Merikangas, PhD
During the past year we have reported our findings of sex-specific associations between cigarette smoking and DSM-IV mood and anxiety disorders including full diagnosis, subthreshold and severe forms, symptoms, impairment and mental health services use using NHANES data. Female smokers showed stati ...
72.
MH002874 (2012) The Neuroregulatory Effects of Gonadal Steroids in Humans
Peter J Schmidt, MD
Behavioral observations show that clinically significant depressive symptoms are rare accompaniments of induced hypogonadism in these healthy premenopausal women. Additionally, neither night-time hot flushes nor disturbed sleep are sufficient to cause depressive symptoms in hypogonadal young women ...
73.
MH002881 (2012) Molecular mechanisms of synapse development and plasticity
Zheng Li, PhD
Synaptic plasticity is an important process through which the nervous system responds to prior experience and adapts to environmental changes. The change in synaptic strength can be transient or last for long periods of time. The long-lasting form of synaptic plasticity plays a crucial role in the r ...
74.
MH002882 (2012) Characterization of miRNAs on neural development and plasticity
Zheng Li, PhD
This year we studied traumatic brain injury (TBI) in rat to identify miRNAs which are important in repressing gene expression and regulating biological processes, such as cell differentiation, proliferation and apoptosis. TBI leads to temporary or permanent structural and functional impairment of th ...
75.
MH002886 (2012) Neural mechanisms of reward processing and emotion
Elisabeth Adams Murray, PhD
Neuropsychological investigations of the prefrontal cortex have shown a clear role for both PFo and PFm in reward-guided behavior and emotion (Izquierdo and Murray 2004; Izquierdo et al., 2005). Damage in either area leads to altered emotion and social behavior as well as disrupted autonomic respons ...
76.
MH002887 (2012) Neural substrates of reward processing and emotion
Elisabeth Adams Murray, PhD
It has been proposed that there is a fundamental dichotomy between the functions of PFo and PFm. PFo is thought to be essential for value-guided object choices whereas PFm is thought to be essential for value-guided action choices. To address this question, we have investigated the selective contrib ...
77.
MH002890 (2012) Integrating EEG/MEG and fMRI: 99-M-0172
Richard Coppola, SB, DSc
Development of MEG data recording and signal processing methods has been very successful. Studies of working memory tasks and auditory processing tasks have shown the ability to localize brain activation and to address issues of phasic versus tonic activity. We are investigating phenotype measures t ...
78.
MH002892 (2012) Synaptic mechanisms of amygdala-dependent behaviors
Alexei Y Morozov, PhD
Fear behaviors, which are driven by the amygdala, can become maladaptive during mental illness. Our main goal is to understand how amygdala circuitry triggers fear behaviors and how this function changes during transition from normal to pathological states. This knowledge will provide information th ...
79.
MH002893 (2012) Learning and plasticity in the human brain
Christopher Ian Baker, PhD
The primary goals of this research are i) to establish the changes in brain processing arising from nervous system damage or dysfunction, ii) to understand how brain plasticity contributes to these changes, and iii) to determine how learning may ameliorate the negative consequences of such changes. ...
80.
MH002895 (2012) Forebrain GABAergic cell-selective genetic manipulation in mice
Kazutoshi Nakazawa, MD, PhD
Since last year we have focused on the following four research questions.
(1) Are there any other phenotypes which are reminiscent of schizophrenia in Ppp1r2-Cre/NR1 mutants? In human schizophrenia, impaired gamma oscillations are consistently reported and are thought to play a crucial role in a n ...
81.
MH002896 (2012) The Neural Basis of Functional MRI Responses
David A Leopold, PhD
We have made a number of measurements, impossible at all but a handful of sites in the world, in which the electrical and fMRI signals are assessed simultaneously. We have done this in awake behaving primates implanted with various types of electrodes. In one study, we used linear arrays of electr ...
82.
MH002897 (2012) Molecular and Cellular Mechanisms of Experience-Dependent Cortical Processing
Kuan Hong Wang, PhD
Our brain can be considered as a type of information processing system like a computer, where input signals need to be first detected and properly represented, then integrated for decision-making and output control. A unique feature of the brain as an information processing system lies in its adapt ...
83.
MH002898 (2012) Visual Adaptation and Neuronal Selectivity
David A Leopold, PhD
In one study, we are exploring several methods to map the brains functional MRI responses to social movies in a meaningful way. Human studies suggest that evaluating the reliability of fMRI signals in individual voxels to multiple presentations of the same movie provides a fresh alternative to conv ...
84.
MH002904 (2012) Characterization of Genetic Mechanisms Contributing to Neuropsychiatric Disorder
Karen F Berman, MD
Researchers in this group identify a potential therapeutic target for the treatment of Schizophrenia, a debilitating disorder affecting approximately 1% of the population. This year the neurobiology group published data describing genetically regulated signaling pathways involving NRG1-ErbB4 and the ...
85.
MH002909 (2012) Object, face and body representations in the human brain
Christopher Ian Baker, PhD
The goal of this research is to understand how we see what we see: how does the brain analyze the light falling on the retina of the eye to encode a world full of objects, people and things?
During the past year we have continued to investigate i) the interaction between bottom up (sensory drive ...
86.
MH002910 (2012) Role of the p75NTR, LTD and the cholinergic system in mediating coping mechanism
Miles Herkenham, PhD
The cellular and molecular mechanisms underlying development of stress-related anxiety disorders remain largely unknown. Exposure to psychogenic stress contributes to the development of anxiety disorders, including post-traumatic stress disorder (PTSD). One approach to studying the pathogenesis of ...
87.
MH002913 (2012) Trial of a Glutamate Antagonist in the Treatment of OCD and Autistic Disorders
Susan Elizabeth Swedo, MD
The serotonin reuptake blocking medications (SSRIs, such as fluoxetine, fluvoxamine and sertraline) have been demonstrated to be efficacious in the treatment of obsessive-compulsive disorder (OCD), but many patients fail to respond to therapy. Treatment-refractory cases are particularly common amon ...
88.
MH002914 (2012) Treatment of Medical Conditions among Individuals with Autism Spectrum Disorders
Susan Elizabeth Swedo, MD
Autism spectrum disorders are defined by deficits of communication and socialization and the presence of restrictive and/or repetitive behaviors. Recent epidemiologic studies have documented an increase in the number of children identified with autism spectrum disorder (ASD) over the past decade and ...
89.
MH002915 (2012) Neuroimmunologic Investigations of Autism Spectrum Disorders (ASD)
Susan Elizabeth Swedo, MD
Autism is defined by its behavioral manifestations: social deficits, impairments in communication and the presence of restricted or repetitive behaviors. The cause of these abnormalities is unknown, but it is strongly suspected that autism spectrum disorders (ASD) result from a combination of genet ...
90.
MH002917 (2012) Office of the Scientific Director
Philip Sung-En Wang
The NIMH Division of Intramural Research Programs'(DIRP) scientists conduct research ranging from studies into the mechanisms of normal brain function, conducted at the behavioral, systems, cellular, and molecular levels, to clinical investigations into the diagnosis, treatment and prevention of men ...
91.
MH002918 (2012) Functional Anatomy of Face Processing in the Primate Brain
Leslie G Ungerleider, PhD
Lesions of the inferior temporal (IT) cortex in humans can result in the clinical syndrome termed prosopagnosia, an inability to recognize familiar faces. Single-cell recordings from IT cortex of monkeys have revealed the existence of neurons that are selectively activated by visual images of faces. ...
92.
MH002919 (2012) Subcellular Microdissection for the Identification of Organelle Proteins
Sanford P. Markey, PhD
Microscopic pathology defines many human diseases, but the chemical composition of most histologically observed subcellular structures remains largely uncharacterized. Currently, there is no method for isolating subcellular areas of interest without disrupting the cells and thus distorting naturally ...
93.
MH002920 (2012) The Cognitive Neuroscience of Autism Spectrum Disorders
Alex Martin, PhD
This past year we have completed several behavioral and brain imaging studies of social perception and social communication in adolescents with Autism Spectrum Disorders (ASD). Our behavioral studies have confirmed that adolescents with ASD have difficulty perceiving specific emotional states from f ...
94.
MH002922 (2012) Psychiatry Consultation Liaison Service Research
Maryland Pao, MD
The NIMH Psychiatric Consultation Liaison Service (PCLS) provides important psychiatric services to the many constituencies of the NIH. While providing such services to the NIH Community, PCLS clinicians conduct research and collaborate with NIH investigators by providing expertise in the areas of p ...
95.
MH002927 (2012) Target validation of novel therapeutic agents in mood disorders
Carlos Alberto Zarate, MD
Project 1: Enkephalinergic compounds for major depression: There is increasing evidence that patients with anxious major depressive disorder (AMDD) have a greater depressive severity, functional impairment, increased risk of suicidality, worse social distress, higher incidence of alcohol and drug ab ...
96.
MH002928 (2012) Frontal striatal systems and dopamine in normal and pathological behavior
Bruno B Averbeck
Our lab is engaged in collaborations with clinical groups to examine behavior in patients with schizophrenia and Parkinsons disease, using tasks which engage frontal-striatal systems to see if patients show deficits in these tasks. Our strategy is to identify behavioural deficits in patient groups, ...
97.
MH002929 (2012) Developing new statisical methods to detect variants involved in complex disease
Yin Yao Shugart, PhD
Nasopharyngeal carcinoma (NPC) has a unique global distribution pattern -- Southeast Asia and some other localized regions of the eastern hemisphere that suggests the disease risk is driven by a combination of environmental exposures and specific genetic factors. Earlier studies have implicated man ...
98.
MH002930 (2012) Developing Stats Methods to Detect Rare Genetics Variants in Human Pedigrees
Yin Yao Shugart, PhD
Next-generation sequencing technologies coupled with the efficient DNA capture methods provide exome sequencing approach to investigate the genetic basis of complex phenotypes. Unlike whole genome association studies (GWAS) which can only discover variation in DNA that is frequent in the population ...
99.
MH002931 (2012) Neurodevelopmental Genomics Supplement
Kathleen R Merikangas, PhD
During the past year, 1,736 youth were enrolled in the study and 250 completed the neuroimaging component of the project, resulting in a total number of 9,236 youth who have undergone the clinical and medical interviews, and cognitive testing, and 1,000 who have completed the neuroimaging component ...
100.
MH002932 (2012) Cohort study of Lausanne (COLAUS) on cardiovascular diseases and depression
Kathleen R Merikangas, PhD
The collection of data from this cohort has now been completed and analyses of the data are now underway. The National Institute of Mental Health (NIMH) Family Study of Affective Spectrum Disorders has included numerous comparable measures of psychiatric and cardiovascular phenotypes that can be ana ...
101.
MH002933 (2012) Endocrine and Neurobiologic Events Accompanying Puberty
Peter J Schmidt, MD
Recruitment for this demanding longitudinal study is in its early stages due in part to the successful development of imaging techniques required to measure gonadal volume in these children with Magnetic Resonance Imaging (MRI), the need for a designated functional MRI to be in place for the perform ...
102.
MH002935 (2012) Mathematical and Statistical Analysis Techniques for in Vivo Imaging Studies
Carolyn E Beebe, PhD
In the current year we have refined our kinetic model analysis methods for estimation of rates of Cerebral Protein Synthesis (rCPS) with L-1-C-11 leucine and PET. Because rCPS tends to change only modestly under different physiological conditions, it is essential that kinetic analyses for determinat ...
103.
MH002936 (2012) Cerebral Protein Synthesis During Sleep and Memory Consolidation
Carolyn E Beebe, PhD
During the 2012 funding period, we addressed the following:
In collaboration with our colleagues from the Walter Reed Army Institute of Research (T.Balkin and D. Picchioni, we use the L-1-11Cleucine positron emission tomography method to measure rCPS in the same subject during three consecutive s ...
Scientific Core
1.
MH002884 (2012) Functional MRI Core Facility
Peter A Bandettini, BS, PhD
Space Utilization:
The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, 3TD, and 7T MRI scanners located within the NMR center and office space on the second flo ...
2.
MH002888 (2012) Scientific and Statistical Computing Core
Robert Cox, PhD
The main mission of the Core is to help NIH researchers with analyses of their functional MRI (brain activation mapping) data. Along the way, we also help non-NIH investigators, mostly in the US but also some abroad. Several levels of help are provided, from short-term immediate aid to long-term dev ...
3.
MH002889 (2012) NIMH MEG Core Facility
Richard Coppola, SB, DSc
The MEG Core staff works interactively with an extensive group of PI's in NIMH, NINDS and NIDCD for study design, task programming development, acquisition protocols, and signal processing and data analysis. Procedures have been setup for data security, transfer and storage. A substantial Policy an ...
4.
MH002894 (2012) Magnetic Resonance Spectroscopy Core Facility
Jun Shen, PhD
As a noninvasive method for measuring concentration and distribution of chemicals in the living brain MRS is an important tool for studying brain function and disorders. However, robust measurement of MRS signals requires highly sophisticated design, implementation and maintenance of various MRS tec ...
5.
MH002899 (2012) Neurophysiology Imaging Facility Core: Functional and Structural MRI
David A Leopold, PhD
The expansion of magnetic resonance imaging in the past decades had greatly changed the way scientists, clinicians, and the public view the human brain. At its essence, MRI is based on the nuclear spin properties of water protons that compose various different brain tissues. Through the resonance ...
6.
MH002901 (2012) Transgenic resources for neuroscience research
James M Pickel, AB, PhD
SUMMARY
The NIMH transgenic core facility has several major functions: 1) to produce transgenics for neuroscience research at NIH 2) develop new transgenic techniques and model systems 3) support research with associated techniques in genetic research in neuroscience and 4) engage in collaborative ...
7.
MH002902 (2012) NIMH Non-Human Primate Research Core
Pamela Noble
-Assessment of neural and behavioral alterations associated with chronic fluoxetine administration in adolescence.
Summary: A primate differential rearing model is used to assess the effects of chronic fluoxetine treatment of juvenile monkeys. Treatment and rearing history are hypothesized to i ...
8.
MH002903 (2012) Procurement and Characterization of Postmortem Brain Tissue
Joel Kleinman, MD, PhD
Since last year, we collected 64 brains, including 14 PTSD cases (6 from Stanley Foundation, 8 from University of Texas Southwest Brain Bank). We refined our collection by transferring cases to the NICHD Brain Bank, the University of Miami Brain Bank, and other NIH labs, as well as discarded formali ...
9.
MH002905 (2012) Neuroimaging Core Facility
Karen F Berman, MD
The Neuroimaging Core has been responsible for optimizing and updating neuroimaging protocols; maintaining, monitoring analyzing and conducting quality control screening of all structural MRI, functional MRI, MR spectroscopy, and DTI data collected by CBDB neuroimaging investigators. In general, the ...
10.
MH002911 (2012) NIMH Instrumentation Core Facility
George Raphael Dold, MME, BSEE
This past year, our Section had the unique opportunity to support the research from more than 35 different Labs & Sections within NIMH, NINDS and NICHD. During the past twelve months, investigators from these labs and branches requested 498 formal projects from our staff. Each of these requests was ...
Clinical Support Services
1.
MH002912 (2012) Office of the Clinical Director
Maryland Pao, MD
CLINICAL RESEARCH SUPPORT: The NIMH OCD is responsible for many critical clinical, administrative, and research-related support services including: 1) administrative oversight and quality performance improvement of NIMH inpatient units and outpatient clinic through monitoring of high risk protocols, ...
Animal Research Infrastructure
1.
MH002924 (2012) Veterinary Medicine Research Branch
James Raber, DVM, PhD
The NIMH Veterinary Medicine Research Branch (VMRB) has successfully provided support to veterinary medical, husbandry and research support to over thirty-three (33) principal investigators in the NIMH IRP with over sixty-nine (69) active animal study protocols. In addition, the Branch has provided ...
Education and Outreach
1.
MH002916 (2012) Office Of Fellowship Training
Barry Bernard Kaplan, PhD
The Office of Fellowship Training (OFT) organized and managed several educational events and programs for the DIRP and the extramural research communities. These events, geared to service the needs of a multidisciplinary basic and clinical training program, encompassed the participation of approxima ...
2.
MH002937 (2012) NIMH IAN with the National Database for Autism Research Program
Philip Sung-En Wang
Achievements in 2012
1. Shared autism data from 25,000 subjects across 170,000 clinical, imaging and genomics instruments.
2. Improved the capabilities for the research community to search the data. Searching is now possible by user defined interests, by data from a laboratory, by data associa ...
3.
MH002938 (2012) Omnitec Solution for the NIMH National Database for Autism Research
Philip Sung-En Wang
Achievements in 2012
1. Shared autism data from 25,000 subjects across 170,000 clinical, imaging and genomics instruments.
2. Improved the capabilities for the research community to search the data. Searching is now possible by user defined interests, by data from a laboratory, by data associa ...
Technology Transfer
1.
MH002925 (2012) Office of Technology Transfer
Suzanne L Winfield, PhD
The Office of Technology Transfer (OTT) negotiates Material Transfer Agreements, Cooperative Research Development Agreements, Confidential Agreements, Clinical Trial Agreements, etc. We also provide guidance and assistance to NIMH researchers, evaluate employee inventions for their patentability and ...


Don't consider myself an 'addictive personality,' however, the 'Spirit' of Crystal Meth struck me immediately -- because very soon after taking my first sniff. I recall realizing that I totally wanted some more! The stuff has a way of making me think I need to do some more. and then some more. In contrast to LSD, for example, whenever I was having a great trip, I had never experienced any unreasonable or motivating impulse to do more acid!
For me, fortunately, my life generally set limits on my financial ability to go off any deep ends, and for a number of years (seven, since I began) I managed to keep my consumption in check. One primary reason, is that I always thought, 'damn if I am going to pay for stuff & use it during an eight-hour-day, and work my tail off for no extra money!' Towards the end, however, the Spirit grew stronger than my willingness to resist, and I spent a good year in excess consumption. What a waste. Although I liked it a lot.
I view ANY substance as having a 'spirit' of it's own - for me, meth was patient and patient, and snuck up on me and won over me, eventually. On the other hand, three years since having touched the stuff, I find myself left without any trace of any creative 'oomph,' which thought I always had thru my life -- which had been, extraordinarily, enjoyably, enhanced, by crystal meth. My reason for 'using.'
I enjoyed meth because I love doing things, making things, building things, painting things -- crystal enabled me to increase my output/enjoyment to an extreme. Whatever 'artist' I had within me, I was motivated to really be! A whole lot!
Since I've quit -- I've been staggeringly depressed, either as a result of quitting cold-turkey, or because thru the past three years, four members of my beloved family died, I was evicted, I left my successful self-employment to care for my elderly mom, until she, too, passed away..
None of all of that was necessarily a result of my using -- however, intellectually, reflectively, so many questions arise, especially because it had grown so important to me, on a daily basis.
Primarily, I find no desire to do much of ANYTHING, anymore. After all -- none of anything in my life has added up to much of anything -- whatever I did. There are many more life-realizations that I won't go into -- suffice it to say, that I cannot entirely attribute recent downturn of live events as effects of any 'use.'
On the other hand, could my use have destroyed my initiative and/or creativity? Life itself can do that, just as well. I'm 50 years old -- I don't generally feel as 'enthusiastic' as I once did. Especially, having recently realized so many disappointments and disillusionments.
So, lately, having nothing but time on my hands to reflect, realizing that I would take up my use again, without hesitation, if I could find any -- it also seems 'rational' to me that at 50 yrs old, maybe I would rather live a shorter, more 'productive' life, than spending any remaining years as an unenergetic 'lump' of aging flesh.
So, there's the rub. To be, or not to be, as long as I might otherwise be able to.
Sooner or later, my demise shall arrive. I am still healthy, but having spent the past three years as a clean, uninspired 'couch potato,' doesn't seem to hold any long term satisfaction -- compared to shortening my time of life and 'using,' however feeling more satisfied and 'motivated' to create 'output.!' I could just 'hang in there,' avoiding unhealthy indulgences, bored to tears as I watch my body deteriorate with age or live a shorter time, more enjoyably and energetically and productively. 'Painting' or 'creating' something until my last moment.
I've read other messages, telling of good reasons not to use -- all good advice -- but I'll bet most of those messages were written by folks 20 to 30 years younger than I am -- I am not looking forward to striving to live thru the next 20 years, growing old and feeble and pathetic and incontinent, etc. etc. My Dad died at the age of 60.  My mother died at age 77 -- in pain and discomfort, for many years, having lived long enough to have surrendered her dignity and self reliance. My older brother died at 47 years old -- always watching his health -- having everything to live for -- postponing his retirement/enjoyment of life -- losing his dreams prematurely. I am now older that my older brother. All in all, the lesson I see, here, is to do what makes me happy! Every day! For as long as I am able.
Crystal meth was something I enjoyed doing, for a while, that 'enhanced' my enjoyment of life. In reflection, I was lucky that my 'using' did not bring me down. Recognizing the strength of its 'spirit,' but it is some thing that I wish I could do, again.
Basically, I wish I could get my hands on some stuff. I've had a wonderful life -- I've been lucky to have been able to have done most of everything I ever wanted to do (before I ever met crystal Meth!). If I were told that I were going to die, soon, truly, I could live with that.
What is causing me concern is the idea of living on and on, for the next twenty years or so, with 'luck,' as my health and my body deteriorates.
People facing imminent demise can 'travel the world,' or whatever, before their time comes. For me, after working 40-hour/weeks for the past thirty years -- only to achieve becoming 50 years old -- and unappreciated, my dream would be to live out my time (feeling like I had the motivation to) go & paint something, build something, create something, do something, the way crystal Meth just made me feel like doing. the way I can't manage to get myself up to feel, lately.
I don't feel like doing much of anything, these days. Can't tell if it's because I 'overdid' a bit in the past, or if it's only natural to feel less energetic at this age. All things considered, I wish I could manage to obtain any kind of pharmaceutical 'assistance,' -- especially in view of children's being prescribed stimulants -- as though that were a good thing to do.
Here am I, a rational, very adult, intelligent human -- able to legally purchase liquor or cigarettes or excessive food -- all detrimental to health -- but unable to legally obtain a bit of something that I would prefer.
Whatta heck-uv-a world!
Ya know, re-reading all that I have just written -- realizing that I've spent over an hour to tell the world at large all about what crystal meth meant to me -- expecially considering that I haven't touched the stuff in over three years -- tells me something about its extraordinary effect upon me -- upon my life -- upon even my thoughts -- 3 years later.!
Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid.


- Source:
Properties:
| Name | Type | Attributes | Description |
|---|---|---|---|
info |
GAME#infoObject |
<optional> |
Infos about this game. |
Global GAME.
Reference it via the GAME
variable.
Methods
pause()
- Source:
Pause the game.
resume()
- Source:
Resume the game.
setGameOverCallback()
- Source:
Set the callback for gameOver.
start()
- Source:
Start the game.
Type Definitions
infoObject
- Source:
Properties:
| Name | Type | Description |
|---|---|---|
name |
string | Name of this game. |
description |
string | Desciption for this game. |
imgUrl |
string | URL to a preview image for this game. |
manual |
string | Information on how to play this game. |
Type:
- object


|
| class | AboutDialog |
| | Simple about dialog More...
|
| |
| class | APMD_Form |
| | This is the main Window (Form) for the Application. A minimal amount of work should be done here, routing most UI events to a subclass to deal with. This is (or runs on) the UI thread, so no blocking work. More...
|
| |
| struct | BoardSquare |
| | Wraps a board location More...
|
| |
| class | ChessBoard |
| | Encapsulates a chess board. The board owns the pieces and the history More...
|
| |
| class | ChessBoardView |
| | Encapsulates the view for the chess board. This is the drawing code More...
|
| |
| class | ChessEngineProcessContainer |
| | Wrapper for the raw process executable More...
|
| |
| class | ChessEngineProcessLoader |
| | The ChessEngineProcessLoader object is responsible for the actual loading of the chess engine process. This decouples knowledge of the Process from the UCIChessEngine object, and distills it down to the basics needed; e.g the data event and the input stream More...
|
| |
| class | ChessEngineResponseReceivedEventArgs |
| | EventArgs for the engine response (external process response) More...
|
| |
| class | ChessGame |
| | ChessGame encapsulates a game "session". It can either start from scratch or from a given starting position. It is responsible for tracking all aspects of the game. A non-exhasutive list: The board (owns the pieces, and moves, and more), time controls, all UI components like a move history or captured list, and of course the chess engine. More...
|
| |
| class | ChessPiece |
| | Encapsulates a chess piece More...
|
| |
| class | DisplayFENDialog |
| | Dialog to show the current FEN. Better than a messagebox, since the textbox can be selected and copied More...
|
| |
| class | EngineOptionsDialog |
| | Options Dialog for the chess engines loaded More...
|
| |
| class | FenParser |
| | Stateles FEN Parser Helper Methods More...
|
| |
| interface | IChessBoardView |
| | Interface for drawing the chessboard More...
|
| |
| interface | IChessEngine |
| | Generic interface for the chess engine (external process). At a bare minumum, we need to be able to send a command and wait for a response More...
|
| |
| interface | IChessEngineProcess |
| | IChessEngineProcess is the minimal set of functionality to wrap the binary process for the engine. More...
|
| |
| interface | IChessEngineProcessLoader |
| | Interface to abstract loading of the actual process More...
|
| |
| class | LegalChessMovesGenerator |
| | Static helpers to generate legal moves for chess pieces More...
|
| |
| struct | MoveInformation |
| | Holds more detailed information on a single move for the GUI. More...
|
| |
| class | NewGameDialog |
| | New game dialog class. This is the Form UI More...
|
| |
| struct | PieceFile |
| | Encapsulates a file on the Chess Board. files are [a-h] and are basically "columns" on the board. More...
|
| |
| class | Program |
| |
| class | PromotionDialog |
| | Simple dialog for selecting promotion of a piece. It is dead simple right now, with a simple radio list to choose from. More...
|
| |
| class | RadioButtonHelper |
| | Wraps reused helper code to get a radio selection. Shared with the simple dialogs. More...
|
| |
| class | RectangleExtensionMethods |
| | Extension methods class for Rectangle
|
| |
| class | UCIChessEngine |
| | Encapsulates a UCI protocol chess engine More...
|
| |
| class | UciChessEngineCommand |
| | Base command object for the UciEngine, all commands derive from this More...
|
| |
| class | UciGoCommand |
| | Start analyzing the current position for the best move. Only take moveTimeInMilliseconds to make up your mind. More...
|
| |
| class | UciInitCommand |
| | This command will initialize the UCI protocol. It should be issued once at the start of the process initialization before other commands are sent (with the exception of UciLoadEngineCommand which loads the actual process) More...
|
| |
| class | UciIsReadyCommand |
| | This command is really meant for internal use by the engine and should not be called by others. The caller needs the underlying process input stream to use the command, and only the engine has it. More...
|
| |
| class | UciLoadEngineCommand |
| | Not a UCI protocol command, but the client issued command to load the process that implements the UCI protocol for use More...
|
| |
| class | UciNewGameCommand |
| | Wraps a "new game" with the engine and resets the board to its initial state More...
|
| |
| class | UciPositionCommand |
| | Tells the engine to set a new position with the board based on a FEN More...
|
| |
| class | UciSetOptionCommand |
| | Wraps a 'setoption' UCI command with required name and optional value field(s) More...
|
| |
|
| enum | PieceColor { PieceColor.White,
PieceColor.Black
} |
| | Chess piece color, only two options, pretty well known.... More...
|
| |
| enum | PieceClass {
PieceClass.King,
PieceClass.Queen,
PieceClass.Rook,
PieceClass.Bishop,
PieceClass.Knight,
PieceClass.Pawn,
PieceClass.EnPassantTarget
} |
| | Filthy peasant or member of the nobility? More...
|
| |
| enum | BoardOrientation { BoardOrientation.WhiteOnBottom,
BoardOrientation.BlackOnBottom
} |
| | Which way should the board be drawn? More...
|
| |
| enum | BoardSide { BoardSide.None = 0,
BoardSide.King = 1,
BoardSide.Queen = 2
} |
| | The Chess Board is split into two sides, King and Queen (left or right) depending on which color you are. More...
|
| |
| enum | GameResult {
GameResult.WhiteWins,
GameResult.BlackWins,
GameResult.Stalemate,
GameResult.Draw,
GameResult.Contested
} |
| | Possible game results More...
|
| |


Description:
The ultimate goal of this course is to familiarize students with ongoing work in the area of technology innovations for underserved communites. This seminar course will review several key publications and presentations on this topic and teach students the necessary skills to analyze and critique this work in useful ways. Class sessions will be dedicated to discussing reading/viewing assignments and each class discussion will be led by students. Assignments will involve analyzing, writing, and presenting critiques of specific projects.


QiYi 6×6 QiFan S
Best Cube at this price.
Shop Adress:
For order call:
Share Your thoughts:
Previous Comments:


Settings
Who Starts
Computer will go first
Computer Symbol
O
X
S
-
*
Player Symbol
X
O
S
-
*
Difficulty
Hard
Medium
Easy
Easy
plays randomly,
Medium
plays somewhat randomly,
Hard
is unbeatable
Start Game


SheetJS Data Preview Live Demo canvas-datagrid component library Source Code Repo Issues? Something look weird? Click here and report an issueDrop a spreadsheet file here to see sheet data... or click here to select a file
Advanced Demo Options: Use readAsBinaryString: (when available)


abstract class PendingTransactionDb : RoomDatabase
Database for pending transaction information. Unlike with the "Data DB," the wallet is free to write to this database. In a way, this almost serves as a local mempool for all transactions initiated by this wallet. Currently, the data necessary to support expired transactions is there but it is not being leveraged.
<init> |
Database for pending transaction information. Unlike with the "Data DB," the wallet is free to write to this database. In a way, this almost serves as a local mempool for all transactions initiated by this wallet. Currently, the data necessary to support expired transactions is there but it is not being leveraged. PendingTransactionDb() |
pendingTransactionDao |
abstract fun pendingTransactionDao(): PendingTransactionDao |


In a review of Ian Jack's The Country Formerly Known As Great Britain, Rachel Cooke writes:
Almost all of these wonderful pieces were commissioned by newspapers and magazines. They would never have worked, and would not now work, on the internet, which is so very interested in speed and sensation and so resolutely uninterested in well-researched thoughtfulness; in essays on bus conductors and Sundays and the seaside; in all the small, strange things that make us who we are.
This seems to me to be utter poppycock. There is abundant “well-researched thoughtfulness” in Interwebshire, plenty about bus conductors and seaside resorts, and a cornucopia of those small, strange things. Hooting Yard is merely one tiny haven of such delights. And surely if one is seeking vapid drivel and “sensation”, one need look no further than the Grauniad and the Observer (where the review appears).
The book itself looks well worth reading:
Jack notes that 1956 was the year in which he and his parents ate their first “tin of baked beans that also included sausages”, a meal taken while sheltering from the rain beneath a bridge at Lanercost Priory, near Hadrian's Wall. “My,” said his father, “but this is good!”
You can rarely go wrong with a sausage anecdote.


If you want an Observable to emit a specific sequence of items before it begins emitting the items normally expected from it, apply the StartWith operator to it.
(If, on the other hand, you want to append a sequence of items to the end of those normally emitted by an Observable, you want the Concat operator.)
cons
start_with
startWith
RxGroovy implements this operator as startWith
.
startWith
RxJava implements this operator as startWith
.
startWith
startWith
is found in the following distributions:
rx.js
rx.all.js
rx.all.compat.js
rx.compat.js
rx.lite.js
rx.lite.compat.js
startWith
RxKotlin implements this operator as startWith
.
StartWith
start_with
start_with
+:


Ireland face potential trip to Belfast to qualify for Euro 2020
by By Digital Desk staffIreland will have to win two away games if they are to qualify for Euro 2020.
The draw, which was made at UEFA headquarters in Nyon, Switzerland, this morning, gave home advantage in the Path B Play-Off final to the winners of .the semi-final between the hosts Bosnia and Herzegovina
and Northern Ireland.
One of 16 countries contesting the play-offs, Ireland already knew that, as one of the lower-ranked sides, they would be playing away in their semi-final, against Slovakia, on Thursday, March 26, 2020, with the venue yet to be confirmed.
Should Northern Ireland and the Republic win their respective semi-finals, it would mean an ‘All-Ireland Final’ would take place at Windsor Park, five days later, on Tuesday, March 31.
Mick McCarthy's men enter the play-off after finishing third in their group: behind Switzerland and Denmark and ahead of Georgia and Gibraltar.
Elsewhere, Scotland must beat Israel and the winners of Norway vs Serbia if they are to progress to the finals that will take place across the continent next summer.
- Additional reporting Digital Desk
READ MORE
Graham Cummins: 'This is what happened when police banged on my door at 7am'


panos_object¶
New in version 2.4.
Synopsis¶
- Policy objects form the match criteria for policy rules and many other functions in PAN-OS. These may include address object, address groups, service objects, service groups, and tag.
Requirements (on host that executes module)¶
- pan-python can be obtained from PyPi https://pypi.python.org/pypi/pan-python
- pandevice can be obtained from PyPi https://pypi.python.org/pypi/pandevice
Options¶
| parameter | required | default | choices | comments |
|---|---|---|---|---|
| address |
no | The IP address of the host or network in CIDR notation. | ||
| address_type |
no | The type of address object definition. Valid types are ip-netmask and ip-range. | ||
| addressgroup |
no | A static group of address objects or dynamic address group. | ||
| addressobject |
no | The name of the address object. | ||
| api_key |
no | API key that can be used instead of username/password credentials. | ||
| color |
no | - The color of the tag object. Valid values are red, green, blue, yellow, copper, orange, purple, gray, light green, cyan, light gray, blue gray, lime, black, gold, and brown.
| ||
| description |
no | The description of the object. | ||
| destination_port |
no | The destination port to be used in a service object definition. | ||
| devicegroup |
no | None | - The name of the Panorama device group. The group must exist on Panorama. If device group is not defined it is assumed that we are contacting a firewall.
| |
| dynamic_value |
no | The filter match criteria to be used in a dynamic addressgroup definition. | ||
| ip_address |
yes | IP address (or hostname) of PAN-OS device or Panorama management console being configured. | ||
| operation |
yes | The operation to be performed. Supported values are add/delete/find. | ||
| password |
yes | Password credentials to use for authentication. | ||
| protocol |
no | The IP protocol to be used in a service object definition. Valid values are tcp or udp. | ||
| servicegroup |
no | A group of service objects. | ||
| serviceobject |
no | The name of the service object. | ||
| services |
no | The group of service objects used in a servicegroup definition. | ||
| source_port |
no | The source port to be used in a service object definition. | ||
| static_value |
no | A group of address objects to be used in an addressgroup definition. | ||
| tag_name |
no | The name of an object or rule tag. | ||
| username |
no | admin | Username credentials to use for authentication. |
Examples¶
- name: search for shared address object panos_object: ip_address: '{{ ip_address }}' username: '{{ username }}' password: '{{ password }}' operation: 'find' address: 'DevNet' - name: create an address group in devicegroup using API key panos_object: ip_address: '{{ ip_address }}' api_key: '{{ api_key }}' operation: 'add' addressgroup: 'Prod_DB_Svrs' static_value: ['prod-db1', 'prod-db2', 'prod-db3'] description: 'Production DMZ database servers' tag_name: 'DMZ' devicegroup: 'DMZ Firewalls' - name: create a global service for TCP 3306 panos_object: ip_address: '{{ ip_address }}' api_key: '{{ api_key }}' operation: 'add' serviceobject: 'mysql-3306' destination_port: '3306' protocol: 'tcp' description: 'MySQL on tcp/3306' - name: create a global tag panos_object: ip_address: '{{ ip_address }}' username: '{{ username }}' password: '{{ password }}' operation: 'add' tag_name: 'ProjectX' color: 'yellow' description: 'Associated with Project X' - name: delete an address object from a devicegroup using API key panos_object: ip_address: '{{ ip_address }}' api_key: '{{ api_key }}' operation: 'delete' addressobject: 'Win2K test'


fun dispatch(event: Event): Unit
Dispatches event to all currently registered listeners.
event - An event to dispatch.
event


Welcome to my personal site.
This where I would put all of my projects. I'm still working on uploading things to this site, but in the meantime, you can checkout my public repos on my GitHub account.
A bit about me
I am a mechanical engineering student at the University of Texas at Austin, with an expected graduation date in the Fall of 2016. I have a variety of interests including mechanical design, software design and implementation, web development and much more. I believe programming and computational skills are key tools for all engineers to have and will be essential to the emerging mathematical and computational economy. It is for this reason that I am supplementing my mechanical engineering degree by studying computer science to earn a Computer Science Certificate through the Elements of Computing program in the Department of Computer Science. I believe my technical knowledge of mechanical engineering combined with my technological skills and passion for innovation give me the capabilities to play an integral part in an engineering team and succeed in a technical engineering role. I am an extremely self driven and motivated individual. I aspire to complete any task brought before me and will always seek out new challenges. Congrats on making it through that ^ jeez.. Here's a cat for your trouble.
What am I doing now?
I'm currently doing a co-op (extended internship) with Nalco Champion a specialty chemical company that works primarily in oil and gas services. I'm doing project engineering/project management work, some manufacturing engineering, and a learning bits of process engineering. Mostly, I'm just learning a ton about the energy business and the day-to-day operations of a large company. It's been a very insightful experience so far. Outside of work, I've been focused on health, programming, and general personal development. (Is this turning into a blog? Who knows)
Contact
Feel free to email me at<EMAIL_ADDRESS>or tweet me @Khalid__Hamza


{% extends "base.html" %}
{% load staticfiles %}
{% block navbar %}
{% if user %}
{% include "navbar_after_login.html" %}
{% else %}
{% include "navbar_before_login.html" %}
{% endif %}
{% endblock navbar %}
{% block content %}
{% if query_id == '1' %}
Search for some farmer
{% elif query_id == '2' %}
Find some post
{% elif query_id == '3' %}
Find some crop
{% elif query_id == '4' %}
View farmers of your area
{% elif query_id == '5' %}
View infected crops
{% elif query_id == '6' %}
See nutrients and associated fertilizers
{% endif %}
{% if query_id == '1' %}
Enter partial / full name of farmer you wish to search. You can also enter partial / full name of the farmer's city/state.
{% elif query_id == '2' %}
Search for any post here. You can search post titles, descriptions, and absolute IDs.
{% elif query_id == '3' %}
Search for any crop here. You can search crop names and their families.
{% elif query_id == '4' %}
Here all the farmers currently registered in your location are listed.
{% elif query_id == '5' %}
View all the crops that are currently infected with some kind of disease.
{% elif query_id == '6' %}
Here, all nutrients and fertilizers are listed.
{% endif %}


EPub class documentation
This class has been designed for ease of use, and to enable ePub book creation on the fly.
The ePub standard contains a lot of parameters that can be set by the user, but in this implementation we are only relying on some of them, the important ones so to speak.
The mandatory fields are:
- Title
setTitle($title)
, where $title is a text string.
- Language
setLanguage($language)
, where $language is a RFC3066 Language code, such as "en", "da", "fr" etc. Language is "en" by default.
- Identifier
setIdentifier($identifier, $identifierType)
, where both arguments are text strings.
The $identifier should be unique for the book. If you don't have anything unique you can use the createUUID
function mentioned later in the documentation.
The $identifierType must be one of these:
- "EPub::IDENTIFIER_URI"
- When using the page URL as $identifier.
- "EPub::IDENTIFIER_ISBN"
- Usually used for published books, where the books unique ISBN number are available.
- "EPub::IDENTIFIER_UUID"
- A generated or random UUID string on the form
c5bc871d-a20a-fc48-ccb4-bb134ae6c564
Where the additional optional fields are:
- Description
- A book description or synopsis
- Author
- Book author or creator.
setAuthor($author, $authorSortKey)
has two arguments, where the sort key can be left blank with ''.
The $authorSortKey is basically how the name is to be sorted, usually it's "Lastname, First names" where the $author is the straight "Firstnames Lastname"
- Publisher
- Book publisher Information, use
setPublisher($publisherName, $publisherURL)
to set the name and URL of the publisher.
- Date
- The publishing date of the book, as a timestamp. If left blank the current date/time will be used.
- Rights
- Test string with the licence and copyrights that may apply to the book.
- Source URL
- The web address for the book, if any are available, but this eBook must be downloadable from somewhere. This is usually also the address used as an identifier, if that parameter is using the "URI" identifier type.


Beta This is a test version of the layout of this page. Take the survey to help us improve it
Research and analysis
This review covers past performance from 2008 to 2012 and recommendations for the future for the national science learning centre.
In 2011, the Wellcome Trust and the Department for Education (DfE) agreed to conduct a joint review every five years, of the regional science learning centres (RSLCs), the NSLC and Project ENTHUSE.
This review will therefore inform the final funding decisions for the NSLC and Project ENTHUSE (with the current funding period ending on 31 July 2013) and will also provide guidance for the DfE on the retendering of the RSLCs (with the current funding period ending on 31 March 2013).


Package com.jme.material.logic
Interface TechniqueDefLogic
-
- All Known Implementing Classes:
DefaultTechniqueDefLogic
,MultiPassLightingLogic
,SinglePassAndImageBasedLightingLogic
,SinglePassLightingLogic
,StaticPassLightingLogic
public interface TechniqueDefLogic
TechniqueDefLogic
is used to customize how a material should be rendered. Typically used to implementlighting modes
. Implementations can registerunmapped defines
in their constructor and then later set them based on the geometry or light environment being rendered.- Author:
- Kirill Vainer
-
-
Method Summary
All Methods Instance Methods Abstract Methods Modifier and Type Method Description Shader
makeCurrent(AssetManager assetManager, RenderManager renderManager, java.util.EnumSet<Caps> rendererCaps, LightList lights, DefineList defines)
Determine the shader to use for the given geometry / material combination.void
render(RenderManager renderManager, Shader shader, Geometry geometry, LightList lights, int lastTexUnit)
Requests that theTechniqueDefLogic
renders the given geometry.
-
-
-
Method Detail
-
makeCurrent
Shader makeCurrent(AssetManager assetManager, RenderManager renderManager, java.util.EnumSet<Caps> rendererCaps, LightList lights, DefineList defines)
Determine the shader to use for the given geometry / material combination.- Parameters:
assetManager
- The asset manager to use for loading shader source code, shader nodes, and and lookup textures.renderManager
- The render manager for which rendering is to be performed.rendererCaps
- Renderer capabilities. The returned shader must support these capabilities.lights
- The lights with which the geometry shall be rendered. This list must not include culled lights.defines
- The define list used by the technique, anyunmapped defines
should be set here to change shader behavior.- Returns:
- The shader to use for rendering.
-
render
void render(RenderManager renderManager, Shader shader, Geometry geometry, LightList lights, int lastTexUnit)
Requests that theTechniqueDefLogic
renders the given geometry. Fixed material functionality such asRenderState
,material parameters
, anduniform bindings
have already been applied by the material, however,RenderState
,uniforms
,textures
, can still be overridden.- Parameters:
renderManager
- The render manager to perform the rendering against.shader
- The shader that was selected by this logic inmakeCurrent(com.jme.asset.AssetManager, com.jme.renderer.RenderManager, java.util.EnumSet, com.jme.light.LightList, com.jme.shader.DefineList)
.geometry
- The geometry to renderlights
- Lights which influence the geometry.
-
-


care {border-style px;} #ffffff;} intensive patients Care infection critically ill coronavirus px; {font-family SARS-CoV- [], control critical epidemic font-size hospitals local designated double; mass medical novel Critical Department Hospital, Intensive January border-color border-width patient solid; {font-style {font-weight COVID- China February Med Medicine, bold courier; em; grid.. health healthcare national prevention pt;}


Class: Aws::DatabaseMigrationService::Types::ReplicationInstance
| Inherits: |
Struct
|
| Defined in: |
(unknown) |
Overview
Instance Attribute Summary collapse
-
#allocated_storage ⇒ Integer
The amount of storage (in gigabytes) that is allocated for the replication instance.
-
#auto_minor_version_upgrade ⇒ Boolean
Boolean value indicating if minor version upgrades will be automatically applied to the instance.
-
#availability_zone ⇒ String
The Availability Zone for the instance.
-
#engine_version ⇒ String
The engine version number of the replication instance.
-
#instance_create_time ⇒ Time
The time the replication instance was created.
-
#kms_key_id ⇒ String
The KMS key identifier that is used to encrypt the content on the replication instance.
-
#multi_az ⇒ Boolean
Specifies if the replication instance is a Multi-AZ deployment.
-
#pending_modified_values ⇒ Types::ReplicationPendingModifiedValues
The pending modification values.
-
#preferred_maintenance_window ⇒ String
The maintenance window times for the replication instance.
-
#publicly_accessible ⇒ Boolean
Specifies the accessibility options for the replication instance.
-
#replication_instance_arn ⇒ String
The Amazon Resource Name (ARN) of the replication instance.
-
#replication_instance_class ⇒ String
The compute and memory capacity of the replication instance.
-
#replication_instance_identifier ⇒ String
The replication instance identifier.
-
#replication_instance_private_ip_address ⇒ String
The private IP address of the replication instance.
-
#replication_instance_private_ip_addresses ⇒ Array<String>
The private IP address of the replication instance.
-
#replication_instance_public_ip_address ⇒ String
The public IP address of the replication instance.
-
#replication_instance_public_ip_addresses ⇒ Array<String>
The public IP address of the replication instance.
-
#replication_instance_status ⇒ String
The status of the replication instance.
-
#replication_subnet_group ⇒ Types::ReplicationSubnetGroup
The subnet group for the replication instance.
-
#vpc_security_groups ⇒ Array<Types::VpcSecurityGroupMembership>
The VPC security group for the instance.
Instance Attribute Details
#allocated_storage ⇒ Integer
The amount of storage (in gigabytes) that is allocated for the replication instance.
#auto_minor_version_upgrade ⇒ Boolean
Boolean value indicating if minor version upgrades will be automatically applied to the instance.
#availability_zone ⇒ String
The Availability Zone for the instance.
#engine_version ⇒ String
The engine version number of the replication instance.
#instance_create_time ⇒ Time
The time the replication instance was created.
#kms_key_id ⇒ String
The KMS key identifier that is used to encrypt the content on the replication instance. If you do not specify a value for the KmsKeyId parameter, then AWS DMS will use your default encryption key. AWS KMS creates the default encryption key for your AWS account. Your AWS account has a different default encryption key for each AWS region.
#multi_az ⇒ Boolean
Specifies if the replication instance is a Multi-AZ deployment. You
cannot set the AvailabilityZone
parameter if the Multi-AZ parameter is
set to true
.
#pending_modified_values ⇒ Types::ReplicationPendingModifiedValues
The pending modification values.
#preferred_maintenance_window ⇒ String
The maintenance window times for the replication instance.
#publicly_accessible ⇒ Boolean
Specifies the accessibility options for the replication instance. A
value of true
represents an instance with a public IP address. A value
of false
represents an instance with a private IP address. The default
value is true
.
#replication_instance_arn ⇒ String
The Amazon Resource Name (ARN) of the replication instance.
#replication_instance_class ⇒ String
The compute and memory capacity of the replication instance.
Valid Values: dms.t2.micro | dms.t2.small | dms.t2.medium |
dms.t2.large | dms.c4.large | dms.c4.xlarge | dms.c4.2xlarge |
dms.c4.4xlarge
#replication_instance_identifier ⇒ String
The replication instance identifier. This parameter is stored as a lowercase string.
Constraints:
Must contain from 1 to 63 alphanumeric characters or hyphens.
First character must be a letter.
Cannot end with a hyphen or contain two consecutive hyphens.
Example: myrepinstance
#replication_instance_private_ip_address ⇒ String
The private IP address of the replication instance.
#replication_instance_private_ip_addresses ⇒ Array<String>
The private IP address of the replication instance.
#replication_instance_public_ip_address ⇒ String
The public IP address of the replication instance.
#replication_instance_public_ip_addresses ⇒ Array<String>
The public IP address of the replication instance.
#replication_instance_status ⇒ String
The status of the replication instance.
#replication_subnet_group ⇒ Types::ReplicationSubnetGroup
The subnet group for the replication instance.
#vpc_security_groups ⇒ Array<Types::VpcSecurityGroupMembership>
The VPC security group for the instance.


Her doctor orders a CT scan and prescribes sumatriptan. Jess punches this into Biolog...
Jess decides to just try ginger, ... and it worked!
So is his bowel. He takes dicyclomine. He spends 5 minutes and enters this into Biolog.
So he finds that peppermint oil pills give him the same relief with less tiredness.
was never severe but her hands and wrists hurt. Tests were negative. 1 day her doctor found a mild iron deficiency. She enters this into Biolog...
She does just that. The Celiac test says she is sensitive to gluten. She goes gluten free and her arthritis and anemia resolve!
He enters :
I started taking allopurinol for my gout, so far no attacks
Anthony mentions this to his doctor and they decide to do a new genetic test to make sure this drug is safe for him.
So Biolog is tracking it.


{% extends "base.html" %}
{% load url from future %}
{% block content %}
{% if profile.verified %}
{% if not profile.moderated and moderation_required %}
Your account has been verified. Account moderators have been notified
and will begin reviewing your account request.
{% else %}
Your account has been verified and is now active. You can now login.
{% endif %}
{% else%}
This account has been already verified or does not exist.
{% endif %}
{% endblock %}


features/home
Packages
com.whatstoday.dynamicfeatures.home.ui
com.whatstoday.dynamicfeatures.home.ui.di
com.whatstoday.dynamicfeatures.home.ui.menu
Index
All Types


curs_addchstr 3x
curs_addchstr(3x) curs_addchstr(3x)
NAME
addchstr, addchnstr, waddchstr, waddchnstr, mvaddchstr,
mvaddchnstr, mvwaddchstr, mvwaddchnstr - add a string of
characters (and attributes) to a curses window
SYNOPSIS
#include <curses.h>
int addchstr(const chtype *chstr);
int addchnstr(const chtype *chstr, int n);
int waddchstr(WINDOW *win, const chtype *chstr);
int waddchnstr(WINDOW *win, const chtype *chstr, int n);
int mvaddchstr(int y, int x, const chtype *chstr);
int mvaddchnstr(int y, int x, const chtype *chstr, int n);
int mvwaddchstr(WINDOW *win, int y, int x, const chtype
*chstr);
int mvwaddchnstr(WINDOW *win, int y, int x, const chtype
*chstr, int n);
DESCRIPTION
These routines copy chstr into the window image structure
at and after the current cursor position. The four rou-
tines with n as the last argument copy at most n elements,
but no more than will fit on the line. If n=-1 then the
whole string is copied, to the maximum number of charac-
ters that will fit on the line.
The window cursor is not advanced, and these routines work
faster than waddnstr. On the other hand, they don't per-
form any kind of checking (such as for the newline,
backspace, or carriage return characters), they don't
advance the current cursor position, they don't expand
other control characters to ^-escapes, and they truncate
the string if it crosses the right margin, rather then
wrapping it around to the new line.
RETURN VALUES
All routines return the integer ERR upon failure and OK on
success (the SVr4 manuals specify only "an integer value
other than ERR") upon successful completion, unless other-
wise noted in the preceding routine descriptions.
NOTES
Note that all routines except waddchnstr may be macros.
PORTABILITY
All these entry points are described in the XSI Curses
standard, Issue 4.
SEE ALSO
curses(3x).
curs_addchstr(3x)
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