Drag this bookmarklet to your bookmarks bar or a tab and start having some fun on other pages too!
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My name is Erik Rothoff Andersson (most of the time I'm Erik Andersson, but it is such a common name in Sweden that the email adress<EMAIL_ADDRESS>was taken before I get could it). I am 18 years of age and currently live and study in Sweden.
If you feel like contacting me<EMAIL_ADDRESS>or you can go to the github page. Feel free to do whatever you want with this app. But remember you saw it first here!
I would like to thank the wonderful community members who have contributed to the improvement of this app.


NOTE: Filters have in effect been replaced by Replacer add-on and scripts which are more powerful and flexible.
Filters will be removed in a future version of ZAP.
This allows you to set filters that are applied to requests and responses.
The following filters are supported by default.This filter will add a special header tag to each request send to the server. So you can track ZAP's requests, when investigating your own web application. It's helpful to have a distinct id for multiple requests, when parsing for example HTTP server's log files.
Request header is modified like this (example):
X-ZAP-RequestID: <sessionName>–<number>
sessionName
is URL encoded name of the sessionnumber
is starting by one; increased on each request; is valid only per session| トップ レベル ツール メニュー | 'Filter...' menu item |
| UIの概要 | ユーザー インターフェイスの概要について | |
| ダイアログ | ダイアログボックスやポップアップの詳細 |


"Mission to Mars" review by R.L. Strong ** stars out of *****
The realm of Science Fiction has always been an allegory of political and or moral sensibilities. The best tales of the genre deal with mankind's struggle for survival or knowledge. Such popular and noteworthy tomes as "Stranger in a Strange Land" by Robert Heinlein, "Childhood's End" by Arthur C. Clarke and "Man in the High Castle" and "Do Androids Dream of Electric Sheep" by Philip K. Dick all deal with man's need for identity and struggle for self worth.
Hollywood has regularly adapted the milieu (if not the message) of Science Fiction since it's beginnings. Most films just created fancy pulp tales with no more thought that the escapism they achieved. It really wasn't until Producer George Pal, took charge of Robert Heinlein's novel "Rocketship Galileo" and crafted the film "Destination Moon", that 'Sci-Fi' (as it is commonly referred to), came into it's own. From there, such diverse filmmakers as Roger Corman to Stanley Kubrick, have sought to express ideas through the medium of the genre. With the release of Touchstone Pictures "Mission to Mars", we have an unabashedly nonchalant Sci-Fi film for those who read The National Enquirer and The Globe.
The film opens on a summer barbecue, as Phil Ohlmyer (Jerry O'Connell) woos a young female with his tales of space glory and the upcoming mission.
Entering the party is Jim McConnell (Gary Sinise), who gave up command of the mission due to the untimely death of his wife, Maggie (Kim Delaney). Luc consoles Jim with Woody's assistance. The three men are friends and carry a fine bond of trust and caring between them. But Jim still longs to set foot on the Red Planet.
The mission is in earnest as Luc and his team land in the Cydonia region of Mars. They send out the rover to investigate the area and discover what seems to be water or ice under the surface. Going out to investigate, Luc and his team approach the famed 'Face on Mars'. A strange noise emanates from the rock. As the team tries to scan through the rock with radar, a violent wind storm erupts, creating a vortex that kills all members of the team, save for Luc.
Back on the space station orbiting Earth, Woody and Jim receive the information that the Mars landing team is missing. Luc's interference laden emergency message urges the two men to attempt a second mission to the red planet in the hopes of rescuing the previous team. The second journey to the Martian world is fraught with danger. Meteorite showers, explosions, and rescues all come into play as the intrepid heroes make there way to the planet's surface. The big question is, is there now or has there ever been intelligent life on Mars. And if so, what is its relationship with us?
Now for the bad news. The entire plot of "Mission to Mars" is based almost wholeheartedly on outdated and preposterous National Enquirer type Martian civilization tripe. The famed 'Face on Mars' becomes the centerpiece of the film, revealing some of the most harebrained sci-fi pabulum the screen has witnessed. Borrowing ideas from such films as "Robinson Crusoe on Mars" (1964), Quatermass and the Pit (1967), "2001: A Space Odyssey", and even Mario Bava's "Planet of the Vampires"('Terrore nello spazio') (1965), "Mission to Mars" is a hodgepodge of ideas that don't add up to a satisfying whole.
While some sequences are wonderfully handled and executed, the film remains flat and un-involving. So much time is giving to establishing the lead characters in the film, but to no good use. The performances are all workmen like, with only Don Cheadle (as Luc) carrying any sort of real chemistry. Gary Sinise is wasted in role that requires him to look as if he is experiencing sleep depravation. And the mistaken idea of having Jerry O'Connell (as Phil Ohlmyer) play his part for comic relief is just too painful to excuse. And the less said about Tim Robbins called in from home performance the better.
The script has a few lapses, namely that after discovering several breaches in the hull of the ship caused by a meteorite shower, no one thinks of checking the fuel tanks or the remainder of the ship for damage. This of course leads to our heroes having to abandon their rescue ship. Also, when one character sacrifices himself, the character takes on a religious demeanor that is completely at odds with the situation.
But the biggest offence in the film is the horrid, intrusive score by Ennio Morricone. Subtlety is non-existent here. In fact in some scenes the music becomes so extravagant that dialogue is almost drowned out. The only sequence in which the score almost works is during the protracted meteorite shower.
The pacing of the film is very leisurely. After the opening introduction of the characters (which lasts a full 22 minutes), we are finally dropped onto the Martian surface. Then, there is another long pause in the plot for more character development, including an elaborate dance sequence in zero gravity. The film could lose about 30 minutes and actually gain some momentum. There are so many scenes of talking heads, discussing what we already know is going to happen, that it drags the film to a dead stop.
The good news is that the film is absolutely sumptuous to look at. The vistas of the planet Mars are majestic and awe inspiring. The design of the numerous spacecraft and suits are all expertly drafted, with a level of realism that hasn't been seen since "2001: A Space Odyssey". The visual effects are just stunning, from the space walk sequences, to the visualization of evolution on Earth. The only fault come with the Martians themselves, which look more like something out of a plastic model kit than something from another world.
Director De Palma stages some wonderfully creative scenes through out the film. The opening sequence alone in a seemingly un-interrupted cut lasting almost 15 minutes (an homage' to Hitchcock's "Rope"), as we are introduced to all of the characters. Scenes in the rescue ship, with its rotating centrifuge, are just amazing in their execution. But the nagging question, is the final explanation worth all of this Sturm und Drang. Sadly it is not.
Director Brian De Palma has crafted an extravagant production. The set design and visual effects are all arresting. But it's the comic strip denouncement that ruin what might have been a fine return to good adventurous, thought provoking science fiction. A disappointing film, but one that might still entertain if you can settle for the visuals.
© 2000 R.L. Strong www.geocities.com/Hollywood/Makeup/5594/reviews.main
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belongs to the author.
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Related links: index of all rec.arts.movies.reviews reviews


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Frank E. Kirby
Frank E. Kirby, 57, of Fort Atkinson, passed away Saturday, November 2, 2019 at his home after a courageous battle with ALS.
Frank was born on June 9, 1962 in Fort Atkinson and graduated from Fort Atkinson High School. He married Kim Sorrel on June 8, 1996 in Fort Atkinson.
Frank made friends wherever he worked, whether it was at Melster Candy, McCains or Wil-Kil Pest Control. He enjoyed driving his Mustang, watching sports and making cashew brittle for family and friends. He was also proud of his Menominee Tribe heritage.
Frank is survived by his wife Kim; children, Sarah (Tim) Rimmer, Jarod (Mylissa) Kirby and Kayla Kirby; sisters, Karen (James) Vernon and Sharon (Albert) Kirby; several grandchildren and many nieces and nephews.
He was preceded in death by his parents, Clayton Kirby and Leah Getty, father-in-law, Jim Getty and daughter, Heather Mather.
Funeral services will be held at 11 a.m. on Thursday, November 7, 2019 at Faith Community Church in Fort Atkinson. Visitation will be from 10 a.m. on Thursday at the church until time of service. Burial will follow in Busseyville Cemetery.
The Dunlap Memorial Home in Fort Atkinson is assisting the family.
www.DunlapMemorialHome.com


WITNESS LIST Criminal Jurisprudence Committee March 6, 2001-2:00P HB 5 For: Dean-Mooney, Laura (Self and MADD, Texas Chairperson) Lewis, Bill (Mothers Against Drunk Driving) Against: Hampton, Keith S. (Texas Criminal Defense Lawyer's Association) Scharmen, George (Texas Criminal Defense Lawyers Association) Strain, H.W. "Sputnik" (Self and Texas Motorcycle Rights Association) On: Taylor, Gary (National Highway Traffic Safety Administration) Registering, but not testifying: For: Donley, Rick (Beer Alliance of Texas) Gray, Alan (Licensed Beverage Distributors) Olsen, Lawrence (Texas Good Roads Association) Sparks, Robert H. (Licensed Beverage Dist, Inc.) On: Lopez, Carlos (Texas Department of Transportation) HB 89 For: Dean-Mooney, Laura (Self and MADD, Texas Chairperson) Harper-Brown, Linda (Self and Tex-21) Hunt, Joyce E. (Self and son) Lee, David (Self) Lewis, Bill (Self and Mothers Against Drunk Driving) McWhorter, Doug (Self) McWhorter, Leslie (Self) Against: Hampton, Keith S. (Texas Criminal Defense Lawyers Association) Scharmen, George (Texas Criminal Defense Lawyers Association) Strain, H.W. "Sputnik" (Self and Texas Motorcycle Rights Association) On: Taylor, Gary (National Highway Traffic Administration) Registering, but not testifying: For: Findeisen, Les (Texas Motor Transportation Association) Jones, Claude (Texas Police Chiefs Association) Lyons, Steve (Houston Police Department) McCarley, James (Dallas Regional Mobility Coalition) Olsen, Lawrence (Self) Zacharias, Larry (City of Richardson Police Department) Against: Riggs, S.A. (Self) On: Lopez, Carlos (Texas Department of Transportation) HB 90 For: Dean-Mooney, Laura (Self and MADD, Texas Chairperson) Harper-Brown, Linda (Self and Tex-21) Lewis, Bill (Mothers Against Drunk Driving) Against: Scharmen, George (Texas Criminal Defense Lawyers Association) On: Taylor, Gary (National Highway Traffic Safety Administration) Registering, but not testifying: For: Findeisen, Les (Texas Motor Transportation Association) Lyons, Steve (Houston Police Department) Mann, Tom (Texas Police Chiefs Association) McCarley, James (Dallas Regional Mobility Coalition) Olsen, Lawrence (Self) Zacharias, Larry (City of Richardson Police Department) On: Lopez, Carlos (TxDOT) HB 91 For: Dean-Mooney, Laura (Self and MADD, Texas Chairperson) Harper-Brown, Linda (Self and Tex-21) Lewis, Bill (Mothers Against Drunk Driving) Against: Scharmen, George (Texas Criminal Defense Lawyers Association) On: Taylor, Gary (National Traffic Highway Safety Administration) Registering, but not testifying: For: Findeisen, Les (Texas Motor Transportation Association) Lyons, Steve (Houston Police Department) Mann, Tom (Texas Police Chiefs Association) McCarley, James (Dallas Regional Mobility Coalition) Olsen, Lawrence (Self) Zacharias, Larry (City of Richardson Police Department) On: Lopez, Carlos (TxDOT) HB 319 Registering, but not testifying: For: Jones, James D. (San Antonio Police Officer's Association) Sanders, Stephen (Self and Texas State Lodge Fraternal Order of Police) Wilkison, Charley (Combined Law Enforcement of Texas) On: McBurney, Ruth (Texas Department of Health) HB 345 For: Bench, Max (Self) Lewis, Bill (Self and Mothers Against Drunk Driving) Registering, but not testifying: For: Hunt, Joyce E. (Self and Son, Mitchie Mitchell) Jones, Claude (Texas Police Chiefs Association) HB 364 For: Buchanan, Bree (Texas Council on Family Violence) Chalmers, Debborah (Self) Denton, Mike (Self) Lawson, Jennifer (Houston Area Women's Center) Lyons, Steve (Houston Police Department) Registering, but not testifying: For: Mann, Tom (Texas Police Chiefs Association) Milam, Cheryl (Self) Nuzzie, Alicia (Houston Area Women's Center) Sloan, Connie D. (Self and Domestic Violence Prevention, Inc.) Soliz, Jennifer (Self) HB 519 For: Boyles, Sherry (Texas Association Against Sexual Assault) Buchanan, Bree (Texas Council on Famlily Violence) Hunter, Linda (Hays-Caldwell Women's Center) On: Durham, Drew T. (Office of Attorney General) HB 599 For: Butts, Nina (Texans Against Gun Violence) Crabtree, Jan (Million Mom March - Dallas Chapter) Fishman, Marsha (Million Mom March - Dallas) Patterson, Jerry (Houston Gun Collectors Association) On: Dawson, Robert (Self) Tripp, Alice (Texas State Rifle Association) Registering, but not testifying: For: Rogers, Jr., Johnnie B. (Houston Gun Collector's Association) Schubert, June M. (Self) Stevens, Nancy (Self and Million Mom March - Tarrant Chapter) HB 600 For: Buchanan, Bree (Texas Council on Family Violence) Denton, Mike (Self) Fealey, Assistant Chief James (Austin Police Chief Stanley Knee) Milam, Cheryl (Self) Sloan, Connie D. (Self and Domestic Violence Prevention, Inc.) Registering, but not testifying: For: Chalmers, Debborah (Self) Crabtree, Jan (Million Mom March - Dallas Chapter) Fishman, Marsha (Million Mom March - Dallas Chapter) Lawson, Jennifer (Houston Area Women's Center) Lyons, Steve (Houston Police Department) Morneau, Pamela (Self) Nuzzie, Alicia (Houston Area Women's Center) Patterson, Jerry (Houston Gun Collector's Association) Rogers, Jr., Johnnie B. (Houston Gun Collector's Association) Schubert, June (Self and Million Mom March - Central Texas Chapter) Soliz, Jennifer (Self) Stevens, Nancy R. (Self and Texans Against Gun Violence and Million Mom March)


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New screening method identifies inhibitors of cancer cell metabolism
by University of California - Los Angeles Health SciencesA new screening system developed by scientists at the UCLA Jonsson Comprehensive Cancer Center leverages redundancy in an important component of a cell - nucleotide metabolism - to help identify new drugs that specifically and potently block processes that are essential for cancer cell growth.
BACKGROUND
There are many small molecule kinase inhibitors, such as Gleevec, that have been developed to target cancers and other diseases. However, scientists still don't fully understand the full effects of these drugs. Current screening methods do not capture the effects these inhibitors may have on other components of cells, such as biochemical metabolic networks. Using their understanding of metabolism, the team designed a new high-throughput screening system that allows for identification of selective inhibitors of metabolic pathways.
METHOD
Working with the Molecular Screening Shared Resource at UCLA, the team performed a large scale analyses of 430 kinase inhibitors that have annotated targets within cellular signaling pathways and many of which are currently being used in the clinic. Unexpectedly, multiple inhibitors were found to block nucleotide metabolism and their targets were revealed using mechanistic studies.
IMPACT
This new metabolism-focused screening approach can be a powerful tool in getting new insight into how existing drugs impact metabolic networks and could potentially provide a new understanding into how these drugs are working in the clinic. In addition to characterization of existing compounds that are already being used for treating cancers and other diseases, this screening method could one day also be applied to identify new small molecule modulators of currently un-targeted metabolic pathways - not only nucleotide metabolism - which can help lead to new drug discoveries.
AUTHORS
The study's senior author is Dr. Caius Radu, professor of molecular and medical pharmacology and a member of UCLA's Jonsson Comprehensive Cancer Center. The first authors are Evan Abt, a postdoctoral researcher, and Ethan Rosser, a graduate student, at the David Geffen School of Medicine at UCLA. Other authors include: Dr. Robert Damoiseaux, professor of molecular and medical pharmacology and director of the Molecular Screening Shared Resources at UCLA; Dr. Arnon Lavie and Dr. Matthew Durst from the University of Illinois at Chicago. Full list of authors are included in the paper.
JOURNAL
The study is published online in Cell Chemical Biology.
FUNDING
The study was funded by the National Science Foundation Graduate Research Fellowship Program.


The "Load" of TensorSpace is the process to read and store the pre-trained ML model in the TensorSpace
model, which makes it possible to use the inference results from the pre-trained network by providing the
input.
The functionality of "Load" is realized by calling the .load() method
of the constructed model object.
Fig. 1 - Load a preprocessed model
wb_sunnyNote:
- filter_center_focus We must preprocess the deep learning models before really loading to the TensorSpace model.
Based on different formats of deep learning models, we list different loading situations below:
Load a preprocessed Keras model
model.load( {
type: "keras",
url: '/PATH_TO_MODEL/model.json',
onProgress: function( fraction ) {
console.log( fraction );
}
onComplete: function() {
console.log( "Complete load model." );
}
} );
.type : String
- filter_center_focus Required.
- filter_center_focus Represents input ML model type.
- filter_center_focus Configure to "keras". To load as a Keras model format.
- filter_center_focus After specifying the type of network format, TensorSpace uses corresponded loader object to handle the actual loading and prediction process.
.url : String
- filter_center_focus Required.
- filter_center_focus Represents the URL to the target network structure file.
- filter_center_focus It is usually a ".json" file which represents the structure of the network.
.onProgress : void
- filter_center_focus Optional.
- filter_center_focus Progress Callback, fired periodically before loading process completed.
- filter_center_focus This callback can be used to monitor the model-loading process, for example, get "fraction" (in range [0, 1]) of model loaded at the moment as parameter.
.onComplete : void
- filter_center_focus Optional.
- filter_center_focus Callback function used to notify the complete on loading ML model.
- filter_center_focus It is designed for handling the event related to the loading complete, such as remove loading screen, console log time duration etc.
Load a preprocessed TensorFlow.js model
model.load( {
type: "tfjs",
url: '/PATH_TO_MODEL/mnist.json',
onProgress: function( fraction ) {
console.log( fraction );
}
onComplete: function() {
console.log( "Complete load model." );
}
} );
.type : String
- filter_center_focus Required.
- filter_center_focus Represents input ML model type.
- filter_center_focus Configure to "tfjs". To load as a TensorFlow.js model format.
- filter_center_focus After specifying the type of network format, TensorSpace uses corresponded loader object to handle the actual loading and prediction process.
.url : String
- filter_center_focus Required.
- filter_center_focus Represents the URL to the target network structure file.
- filter_center_focus It is usually a ".json" file which represents the structure of the network.
.onProgress : void
- filter_center_focus Optional.
- filter_center_focus Progress Callback, fired periodically before loading process completed.
- filter_center_focus This callback can be used to monitor the model-loading process, for example, get "fraction" (in range [0, 1]) of model loaded at the moment as parameter.
.onComplete : void
- filter_center_focus Optional.
- filter_center_focus Callback function used to notify the complete on loading ML model.
- filter_center_focus It is designed for handling the event related to the loading complete, such as remove loading screen, console log time duration etc.
Load a preprocessed TensorFlow model
model.load( {
type: "tensorflow",
url: "/PATH_TO_MODEL/model.json",
outputsName: [ "Maximum", "Const_1", "Maximum_1", "Const_2", "Maximum_2",
"Const_3", "Maximum_3", "Const_4", "Maximum_4", "Const_5",
"Maximum_5", "Const_6", "Const_7", "Const_8", "add_8" ],
onProgress: function( fraction ) {
console.log( fraction );
}
onComplete: function() {
console.log( "Complete load model." );
}
} );
.type : String
- filter_center_focus Required.
- filter_center_focus Represents input ML model type.
- filter_center_focus Configure to "tensorflow". To load as a TensorFlow model format.
- filter_center_focus After specifying the type of network format, TensorSpace uses corresponded loader object to handle the actual loading and prediction process.
.url : String
- filter_center_focus Required.
- filter_center_focus Represents the URL to the target ML model file.
- filter_center_focus It is usually a ".pb" file which is converted after tfjs-converter.
.outputsName : String[]
- filter_center_focus Optional.
- filter_center_focus Required if the TensorFlow model is not preprocessed for multiple outputs.
- filter_center_focus The names listed should be valid tensor names which are used for collecting the data from corresponded intermediate tensors.
- filter_center_focus Make sure the name order is the same as the one implemented in TensorSpace.
.onProgress : void
- filter_center_focus Optional.
- filter_center_focus Progress Callback, fired periodically before loading process completed.
- filter_center_focus This callback can be used to monitor the model-loading process, for example, get "fraction" (in range [0, 1]) of model loaded at the moment as parameter.
.onComplete : void
- filter_center_focus Optional.
- filter_center_focus Callback function used to notify the complete on loading ML model.
- filter_center_focus It is designed for handling the event related to the loading complete, such as remove loading screen, console log time duration etc.


Changelog
Version 1.10 (19-Jul-2018)
- New end-to-end firmware signing support
- All firmware is now required to be signed
- New new Httpd daemon for web server support
- New OTA firmware update support in Httpd
- New
Sys.updateFirmware
method - New
PushCmd
to simplify pushing firmware from CLI - Update
Sys
to log events (mount partition, updateFirmware, reboot, etc) - Update AsmCmd to display system version in output
- Update AsmCmd to download system images from GitHub
- Update default pod blacklist to be stricter:
- Saves 1.37MB bytes off release fw size
- Added to blacklist:
build
,compiler
,compilerDoc
,compilerJava
,compilerJs
,email
,fandoc
,fanr
,fansh
,obix
,sql
- Update systems to 1.4
- Fix BurnCmd to sort release filenames
- Fix Networkd.list argument bug
Version 1.9 (26-Jun-2018)
- Rename
rootfs-additions
->rootfs_overlay
- Update toolchains to
1.0.0
- Convert
system-bbb
->system-bb
to reflect broader board support - Update systems to
1.3
Version 1.8 (29-Nov-2017)
- Change licence to Apache License 2.0
- Official support for
rpi0
- Update systems to
1.2
- Remove Erlang and dependencies from base system; we already did not distribute OTP releases, but this stills saves ~1MB off release fw size and cuts Buildroot make times from ~25min down to ~15min
- Update toolchains to
0.11.0
- Add
Cmd
warnings for retiredstuds.props
andfaninit.props
properties
Version 1.7 (15-Aug-2017)
- Update systems to
1.1
- see BitBucket for details:- bbb changelog
- rpi3 changelog
- Initial support for
rpi0
- Fix AsmCmd to not delete local system source tarballs
- Fix BurnCmd to prompt when multiple releases found
- Fix Networkd to flush addr before assigning a static IP address
- Add basic DHCP support
- Add support for reading fwup firmware props with
Sys.fwActiveProps
andSys.fwProps
- Rework
/data
mount to useSys.mountData
and support auto-reformatting if partition could not be mounted. Thefs.mount
option infaninit.props
is no longer used. - Update serial console tutorial to include rpi3
Version 1.6 (21-Jul-2017)
- Add
studs burn --upgrade
option to perform a--task upgrade
during burn - Fix
faninit
to start java under/app/fan
working directory - Networkd: rename fields
ipaddr,netmask -> ip,mask
- Networkd: add
router
field for default route - Fix
Ntpd.servers
to be mutable - Add
Ntpd.sync
to block until time is acquired - Add
libfan
for Fantom-JNI library support - Networkd: fix to invoke
res_init
after updating/etc/resolve.conf
- Fix
Daemon.cur
design to properly work across actors - Blacklist unnecessary pods during
AsmCmd
(saves2.88MB
off release fw size) - Add support for
pod.blacklist
andpod.whitelist
instuds.props
- Fix
Gpio.listen
to passmode
to fangpio - Add
Gpio.listen
timeout
argument - Add
Sys.shutdown
method - Add support for configuring JVM heap size with
jvm.xmx
infaninit.props
Version 1.5 (4-May-2017)
- Add
repo.public
pod.meta forstuds,studsTools
for Eggbox - Add
--clean
option forAsmCmd
to deletestuds/systems/
andstuds/jres/
intermediate files - Add
studs.props
support for configuring which JRE compact profile to use - Make JRE profile default to
compact1
(saves6MB
off release fw size) - Update
GettingStarted
to include Linux installation instructions - Fix
AsmCmd
JRE setup to work on Linux - Beef up
Building.md
docs
Version 1.4 (12-Apr-2017)
- New
inspect
on-device unit testing app: BitBucket - Add
/etc/sys.props
available on device at runtime - Add
studs::Sys
for/etc/sys.props
access and reboot support - Working Uart.read/write support; fix to correctly configure
UartConfig
on open - Prototype
studs::Gpio
- Prototype
studs::I2C
- Prototype
studs::Spi
- Indicate release file size in
AsmCmd
- Remove
DaemonMgr
and simply useDaemon.start
- Show duration time for
AsmCmd
Version 1.3 (29-Mar-2017)
- Change versioning to use simpler
<major>.<minor>.<patch>
convention - Rework build scripts to move Toolchain into studsTools
- Cleanup dependencies so fanr install will work
- Pack encoder/decoder
- BurnCmd: prompt when multiple disk devices found
- Proc.sinkErr
- Prototype DevTree
- Prototype Uart API
- Rename DaemonSupervisor -> DaemonMgr
Version 1.0.2 (18-Jan-2017)
- Move repo to https://bitbucket.org/studs/core
- Rename BuildCmd -> AsmCmd
- Add some real-world functionality into
init
skeleton Main - Add support for
~/.studs
profile - Add support for looking up jre.tar.gz via
jre.dirs
profile prop - Rework Cmd to model studs.props with Props
- Add support for using custom systems via
target.xxx.uri
system.prop
Version 1.0.1 (2-Oct-2016)
- faninit: add support for fs.mount option
- faninit: add support for tty.console option
- Add Daemon and DaemonSupervisor API
- Add Proc API
- Add Ntpd
- Add Networkd
- Update tools to use our own system packages hosted on BitBucket
Version 1.0.0 (14-Sep-2016)
Initial bare-bones working version with minimal support for faninit, booting JVM, and basic LED support


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BigDataScript
About, contact info, feature requests & bug reports
About, contact info, feature requests & bug reports
This project is maintained by Pablo Cingolani.
Community: BigDataScript user's group
Acknowledgements and special thanks to (in order of appearance)
Please send any bug reports using GitHub
Important: Try BigDataScript's latest version. BigDataScript is updated often, may be the bug has already been corrected.
Note: A bug report should include at least
bds
source file that clearly shows the bug condition).
You can ask question to the BigDataScript user's group
A few guidelines when asking for help:


The SMARTS file format was originally developed by Pete Kenny for use with a program called Structanal, for counting substructural occurrences in molecules. It's a relatively simple format that has stood the test of time, although at least one of the elements is no longer strictly necessary. The SMARTS are specified one line per definition:
benzene c1ccccc1 1 0 biphenyl [$benzene]-[$benzene] 1 1The first field is the label for the SMARTS, the second is the SMARTS definition, the third is the redundant field, and the fourth is either a 0 or a 1, and denotes whether the definition is a vector binding (or SMARTS sub-definition) or a full definition. In the example above, the benzene SMARTS is a vector binding, the biphenyl SMARTS uses it in its definition. Now that we use OpenEye's OEChem routines for the SMARTS matching, the distinction is no longer strictly necessary, but is kept in for historical reasons and/or backward compatibility.
Any line that starts with a # is treated as a comment. You can't have comments part-way along a line, as you can with, for example, shell scripts, because a # is also used in SMARTS to mean a triple bond, so there would be ambiguity. There's no problem at the start of the line, as that's where the SMARTS name goes.
The Points file was originally developed for Plurality, but is also used in Triphic, Loob and SMG. The purpose is to group SMARTS definitions together so that they are treated equivalently. The motivation behind it was the need to be able to treat the centroids of different-sized rings as equivalent, particularly so that aromatic ring centroids for 5- and 6-membered rings could be treated as the same type of pharmacophoric point. This is not possible by merging SMARTS definitions as in
arom5 a1aaaa1 1 0 arom6 a1aaaaa1 1 0 ring [$arom5,$arom6] 1 1(normal SMARTS_file format). When two SMARTS sub-definitions specify different numbers of atoms, the SMARTS matcher returns just the 'head' atom of the SMARTS. In a generic ring such as those above, it is completely arbitrary which atom is returned, since they are all equivalent, so the ring position is not unambiguously determined. The only way to do so is to match all the atoms and take the centroid or average of the atom positions. To do this in the example above, one must match the SMARTS patterns separately and combine them at a higher level than the SMARTS search, and that's what the Points file is for.
The format is very straightforward. Each point type is specified on a separate line, consisting of the point name and the names of the SMARTS definitions that describe the point. There are also a few keywords that are interpreted by the file parser, of which more later. An example of a Points file commonly used for pharmacophore searching is
# define points for donor, acceptor, aromatic an aliphatic hydrophobe donor NeuDon acceptor NeuAcc aromatic AromFive AromSix hphobe ITMOC_ALO # directional vectors for points H_VECTOR_POINTS donor LP_VECTOR_POINTS acceptor RING_NORMAL_POINTS aromaticLines that start with a # are treated as comments and ignored. The first two point types defined, donor and acceptor, have only 1 SMARTS definition associated with them. The third point type, aromatic is the centroid of atoms hit by either SMARTS definition AromFive or AromSix. The fourth point type, hphobe is defined by a keyword (see below) rather than a SMARTS definition. The final 3 lines of the file use keywords (see below) associated with the points previously defined.
The words in upper case in the above example are keywords that some of the programs that use Points files recognise and act upon. If you use them in a Points file for a program that doesn't care, they will be ignored. The recognised words are:


| signal_stage {lifecycle} | R Documentation |
signal_stage()
allows you to signal life cycle stages other than
deprecation (for which you should use deprecate_warn()
and friends).
There is no behaviour associated with this signal, but in the future
we will provide tools to log and report on usage of experimental and
superseded functions.
signal_stage(stage, what, env = caller_env())
stage |
Life cycle stage, either "experimental" or "superseded". |
what |
String describing what feature the stage applies too, using
the same syntax as |
env |
Pair of environments that define where These are only needed if you're calling |
foofy <- function(x, y, z) { signal_stage("experimental", "foofy()") x + y / z } foofy(1, 2, 3)


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Chicken corned beef biltong pork loin capicola tongue, shoulder frankfurter ham hock rump. Sirloin filet mignon ham meatloaf short ribs, shoulder jowl corned beef kevin cow tri-tip salami pastrami pork.
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Chicken biltong tongue turkey sirloin, short loin beef ribs.
Strip steak swine tongue spare ribs filet mignon capicola.
Short ribs tongue landjaeger ribeye pastrami meatball prosciutto t-bone.
Bacon ipsum dolor sit amet kevin ball tip shoulder, bacon beef ribs boudin short ribs sausage pork loin biltong. Spare ribs pork chop boudin beef ribs short loin prosciutto. Rump jowl shankle filet mignon sirloin ham hock, tail kevin fatback boudin beef ribs. Short ribs flank pork turducken fatback salami bacon shankle boudin porchetta kielbasa sirloin bresaola.
Spare ribs salami chicken porchetta, fatback andouille frankfurter. Ground round cow tri-tip turkey sirloin tenderloin. Ham biltong frankfurter beef landjaeger. T-bone capicola pork belly turkey sausage tri-tip, filet mignon kevin tail. Strip steak shank sausage meatloaf ham shoulder kielbasa pork chop. Landjaeger ground round turducken, kielbasa brisket hamburger swine short ribs tongue pork rump porchetta fatback.
Bresaola doner short loin, pork frankfurter prosciutto salami ball tip bacon strip steak rump. Pork belly boudin capicola pork meatball leberkas meatloaf. Venison andouille ham hock kevin swine prosciutto short ribs short loin porchetta rump pork loin. Strip steak kielbasa meatball rump turkey bresaola capicola pork. Fatback kevin sirloin brisket shoulder. Capicola pig ham, short loin tail doner meatball beef ribs ball tip shankle landjaeger.
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Back to all supervision subjects.
Here are the topics, questions, and reading lists for the Part 1B Ethics supervisions in the Philosophy Tripos at Cambridge. Students must choose just one question when more than one is listed. Only four topics will be covered.
1 Practical reason
Questions:
- ‘If people’s reasons for action depend on their desires, then people without at least some desire to be good have no reason to be good. So, people’s reasons for action don’t depend on their desires.’ Is this a good argument?
- ‘You are obligated to $\varphi$ only if you have reason to $\varphi$. You have reason to $\varphi$ only if you are motivated to $\varphi$. You are not motivated to $\varphi$; therefore, you are not obligated to $\varphi$.’ Discuss.
Primary reading:
- Bernard Williams, ‘Internal and External Reasons’.
- Kieran Setiya, ‘Against Internalism’.
- Julia Markovits, ‘Why be an Internalist about Reasons?’.
- Sharon Street, ‘In Defense of Future Tuesday Indifference: Ideally Coherent Eccentrics and the Contingency of What Matters’.
Further reading:
- Mark Schroeder, Slaves of the Passions (chs. 1 and 6, see also chs. 5 and 11).
- Bernard Williams, ‘Internal reasons and the obscurity of blame’.
- John McDowell, ‘Might there be external reasons?’.
- David Sobel, ‘Subjectivism and Reasons to be Moral’
- Christine M. Korsgaard, ‘Skepticism about Practical Reason’
- Kate Manne, ‘Internalism about reasons: sad but true?’.
- Smith, ‘The Humean Theory of Motivation’ and ‘The Argument for Internalism: Reply to Miller’.
2 Early modern moral philosophy
Questions:
- What grounds the normative authority of morality? Answer with reference to early modern voluntarism and rationalism.
- Leibniz and Spinoza both disagree with voluntarism. Are their reasons for doing so compatible? Are they right?
At the moment (2022-2023), Spinoza is not examinable. You may still choose to read him and answer the second question, but should expect to do this on top of the primary readings.
Overview:
- Schneewind, ‘Voluntarism and the Foundations of Ethics’.
Primary readings about all of the central thinkers can be found in Schneewind’s Moral Philosophy from Montaigne to Kant. Choose among chapters about
- Samuel Pufendorf,
- Thomas Hobbes,
- Benedict de Spinoza,
- Gottfried Wilhelm Leibniz,
- Samuel Clarke, and
- Francisco Suarez.
Further Reading:
- Spinoza, Ethics (especially 1p17 and 4p72).
- Darwall, ‘Pufendorf on Morality, Sociability, and Moral Powers’.
- Haakonssen, ‘Early Modern Natural Law Theories’.
- Irwin, The Development of Ethics: Volume 2: From Suarez to Rousseau (especially chapter 32).
3 Helping and harming
3.1 Demands of beneficence
Questions:
- ‘We always ought to do what is best. So there are no “supererogatory” actions.’ Discuss.
- Are there limits to the duty of beneficence?
- Should you be a moral saint?
Primary reading:
- Singer, ‘Famine, Affluence, and Morality’.
- Baron, ‘Kantian Ethics Almost Without Apology’.
- Buss, ‘Needs (Someone Else’s), Projects (My Own), and Reasons’.
- Wolf, ‘Moral Saints’.
Further reading:
- Unger, ‘Living High and Letting Die: Our illusion of innocence’.
- Melden, ‘Saints and Heroes’.
- Herman, ‘The Scope of Moral Requirement’.
- Cullity, ‘The Moral Demands of Affluence’.
- Hill, ‘Meeting Needs and Doing Favors’.
- Murphy, ‘The Demands of Beneficence’.
- Miller, ‘Beneficence, Duty and Distance’.
3.2 Aggregation
Questions:
- Other things being equal, given the choice between saving a smaller or greater number of people, you should save the greater number. However, other things being equal, given the choice between saving a life or saving many people from minor injury, you should save a life. Are these two commitments consistent?
- ‘There is no number of mild headaches whose relief would outweigh saving the life of an innocent person.’ Discuss.
Primary reading:
- Norcross, ‘Comparing Harms: Headaches and Human Lives’.
- Scanlon, ‘The Structure of Contractualism’.
- Taurek, ‘Should the Numbers Count?’.
- Broome, ‘Fairness’.
Further reading:
- Dougherty, ‘Rational Numbers: A Non-Consequentialist Explanation Of Why You Should Save The Many And Not The Few’.
- Fried, ‘Can Contractualism Save Us from Aggregation?’.
- Hirose, ‘Saving the Greater Number Without Combining Claims’.
- Otsuka, ‘Saving Lives, Moral Theory, and the Claims of Individuals’.
3.3 Contractualism
Question:
Is an act permissible if it is compatible with a set of principles that no one could reasonably reject?
Primary reading:
- Parfit, ‘Contractualism’.
- Sen and Williams, ‘Contractualism and Utilitarianism’.
- Scanlon, ‘What We Owe to Each Other’.
- Ashford, ‘The Demandingness of Scanlon’s Contractualism’.
Further reading:
- Brand‐Ballard, ‘Contractualism and Deontic Restrictions’.
- Darwall, ‘The Second-person Standpoint: Morality, respect, and accountability’.
- Gauthier, ‘Morals By Agreement’.
- Hampton, ‘Feminist Contractarianism’.
- Kumar, ‘Defending the Moral Moderate: Contractualism and Common Sense’.
- Wallace, ‘Scanlon’s Contractualism’.
5 Normative powers
5.1 Consent
Questions:
- How does the fact that two adults both consent to something change their normative situation?
- What is required for someone’s consent to be valid?
- ‘You wrong another person by performing an action if they could not reasonably consent to this action.’ Is this right?
Primary reading:
- Korsgaard, ‘Kant’s Formula of Humanity’.
- O’Neill, ‘Between Consenting Adults’.
- Beauchamp, ‘Autonomy and Consent’.
- Conly, ‘Seduction, Rape, and Coercion’.
- Dworkin, ‘The Theory and Practice of Autonomy’.
Further reading:
- Manson, ‘How to Rethink Informed Consent’.
- Owens, ‘The Possibility of Consent’.
- Parfit, ‘Possible Consent’.
- Scanlon, ‘The Value of Choice’.
- Wertheimer, ‘Consent to Sexual Relations’.
- West, ‘Sex, Law, and Consent’.
5.2 Promise
Questions:
- Are you morally obligated to keep your promise to a dead person?
- In virtue of what is a promise binding?
Primary reading:
- Owens, ‘Shaping the Normative Landscape’.
- Rawls, ‘Two Concepts of Rules’.
- Scanlon, ‘Promises and Practices’.
- Gilbert, ‘Scanlon on Promissory Obligation: The Problem of Promisees’.
Further reading:
- Narveson, ‘Promising, Expecting, and Utility’.
- Shiffrin, ‘Promising, Intimate Relationships, and Conventionalism’.
- Thomson, ‘Giving One’s Word’.
- Watson, ‘Promises, Reasons, and Normative Powers’.
- Southwood, ‘Promises Beyond Assurance’.
6 Virtue ethics
Questions:
- Why should an agent be virtuous?
- Even if all virtuous actions are right, are they right because they are virtuous?
Primary reading:
- Aristotle, Nicomachean Ethics (Book 2, chs. 1–7; Book 6, chs. 9–11).
- Alfano, ‘Character as Moral Fiction’.
- Annas, ‘Intelligent Virtue’.
- Anscombe, ‘Modern Moral Philosophy’.
- Wolf, ‘Moral Psychology and the Unity of the Virtues’.
Further reading:
- Alfano (Ed.), Current Controversies in Virtue Theory.
- Snow, The Oxford Handbook of Essays on Aristotle’s Ethics Virtue.
- Badhwar, ‘The Limited Unity of Virtue’.
- Broadie, ‘The Problem of Practical Intellect in Aristotle’s Ethics’.
- Doris, ‘Persons, Situations, and Virtue Ethics’.
- Foot, ‘Virtues and Vices’.
- Harman, ‘Moral Philosophy Meets Social Psychology: Virtue Ethics and the Fundamental Attribution Error’.
- Hursthouse, ‘The Central Doctrine of the Mean’.
- Kamtekar, ‘Situationism and Virtue Ethics on the Content of Our Character’.
- McDowell, ‘Virtue and Reason’.
- Nussbaum, ‘Non‐Relative Virtues: An Aristotelian Approach’.
- Pakaluk, ‘Aristotle’s Nicomachean Ethics: An introduction’.
- Prinz, ‘The Normativity Challenge: Cultural Psychology Provides the Real Threat to Virtue Ethics’.
- Railton, ‘Two Cheers for Virtue: or, Might Virtue Be Habit Forming?’.
- Rorty, Essays on Aristotle’s Ethics.
- Russell, ‘Phronesis and the Virtues’.
- Snow, ‘Comments on Intelligent Virtue: Outsmarting Situationism’.
- Sreenivasan, ‘Errors about Errors: Virtue Theory and Trait Attribution’.


+++ title = "St. Christopher's Inn, Bath" slug = "st-christophers-inn-bath" date = 2007-10-25T11:00:00+10:00 tags = ["accommodation"] locations = ["england/bath"] draft = false summary = """
St. Christopher's Inn is a great little hostel in the pub-infested centre of Bath. The bottom floor of the place is a regular pub, actually — open to the public every evening, and it gets just as many locals as it goes guests coming for a drink. It's not the greatest value for money (but nothing is in Bath), and it does have a few eccentric little annoyances; but it's good fun, and a nice place to crash for a few nights.
""" +++St. Christopher's Inn is a great little hostel in the pub-infested centre of Bath. The bottom floor of the place is a regular pub, actually — open to the public every evening, and it gets just as many locals as it goes guests coming for a drink. It's not the greatest value for money (but nothing is in Bath), and it does have a few eccentric little annoyances; but it's good fun, and a nice place to crash for a few nights.
Rooms: fairly basic — a bit crowded, and the noise and light from the street outside can be bad on weekends.
People: nice crowd, all young backpackers — best to meet people in the secret common room up top, rather than down in the bar.
Staff: the bar stuff down in the pub double as hostel reception staff. They'll give you the keys and take your money, but that's about it.
Location: centre of Bath, 5 minute walk from the bus and train stations, and near all the pubs and shops.
Food: the free breakfast isn't bad, and is all-you-can-eat. Don't buy lunch or dinner here (you can get it downstairs, in the pub) — mega ripoff.
Internet: super-ripoff £1 per 20 minutes, and only 1 PC available. But that's standard for Bath. My advice is to just not go online while in this town.
Hot water: nice and hot — but the special "water-saving taps" need to be whacked every 5 seconds, or the shower just stops! Very annoying.


Sample: NA12878_03 (ex1)
sample sex: female
Processing system: HaloPlex HSP v2
Processing system type: Panel Haloplex
Reference genome: GRCh37
Date: 19.02.2021
Analysis pipeline: megSAP 0.2-486-gc928f885
Analysis software: cppNGSD-TEST
Phenotype information
Target region
The target region includes CCDS ("consensus coding sequence") of the genes listed below ±20 flanking bases of the intronic sequence. It may comprise additional exons and/or flanking bases.
Name: panel
Genes analyzed: 3 (see coverage statistics)
Criteria for variant filtering
- Allele frequency ≤ 1.00%
Small variants in target region: 135
SNVs/InDels selected for report: 2
CNVs selected for report: 2
SVs selected for report: 3
| Variant | Genotype | Genes | Details | Class | Inheritance | gnomAD allele frequency (control cohort) | RNA |
| chr13:40793233 T > A | hom (comp-het) | SLC25A15 | SLC25A15:ENST00000338625.1/NM_014252:c.7T>A:p.Ser3Thr | 3 | n/a | n/a | splicing effect validated by RNA dataset |
| OMIM ID: 603861 Details: GENE=SLC25A15 PHENOS=Hyperornithinemia-hyperammonemia-homocitrullinemia syndrome,238970,Autosomal recessive | |||||||
| chr16:89531961 G > A | het (de-novo) (mosaic) | SPG7 | SPG7:ENST00000268704.1:c.1045G>A:p.Gly349Ser | 5 | n/a | 0.080% | n/a |
| OMIM ID: 602783 Details: GENE=SPG7 PHENOS=Spastic paraplegia 7,autosomal recessive,607259,Autosomal recessive,Autosomal dominant |
| CNV | Position | Size | copy-number | Genes | Class | Inheritance | RNA |
| deletion | chr21:10541092-10649856 | 108.765 kb / 22 regions | 1 (comp-het) | IGHV1OR21-1, TPTE | n/a | n/a | no splicing effect found in RNA dataset |
| deletion | chr21:26799369-26991734 | 192.366 kb / 13 regions | 0 (comp-het) | n/a | n/a | no splicing effect found in RNA dataset |
| SV | Position | Size | Genotype | Genes | Class | Inheritance | RNA |
| insertion | chr1:934143-934144 | hom | HES4 | n/a | n/a | RNA dataset not usable | |
| translocation | chr1:1584540-1584550 <-> chr19:2301860-2301870 | hom | n/a | n/a | n/a | ||
| deletion | chr1:1598413-1598580 | 0.168 kb | hom | SLC35E2B | n/a | n/a | n/a |
| variant type | regions | Genes | Inheritance | comment |
| uncalled CNV | chr2:123456-789012 | EPRS | AR | This is a comment! And it has multiple lines! |
Classification of variants:
Classification and interpretation of variants: The classification of variants is based on the criteria of Plon et al. (PMID: 18951446). A short description of each class can be found in the following
Class 5, pathogenic variant: The variant is considered to be the cause of the patient's disease.
Class 4, probably pathogenic variants: The identified variant is considered to be the probable cause of the patient's disease. This information should be used cautiously for clinical decision-making, as there is still a degree of uncertainty.
Class 3, variant of unclear significance (VUS): The variant has characteristics of being an independent disease-causing mutation, but insufficient or conflicting evidence exists.
Class 2, most likely benign variants: The variant is not likely to be the cause of the tested disease. Class 2 variants are not reported, but can be provided upon request.
Class 1, benign variants: The variant is not considered to be the cause of the tested disease. Class 1 variants are not reported, but can be provided upon request.
Coverage statistics of target region
Average sequencing depth: 125.47
Average sequencing depth (chrMT): 0.00
Gap report based on entire target region
Bases: 271536
Percentage of regions with depth <20: 15449
Percentage gaps: 5.69%
Genes without gaps:
Genes with incomplete coverage (missing bp in brackets): CYP7B1 (243), SLC25A15 (129), SPG7 (126)
Details regions with depth <20:
| Gene | Bases | Chromosome | Coordinates (hg38) |
| CYP7B1 | 243 | chr8 | 64615713-64615740, 64616216-64616218, 64624393-64624515, 64798456-64798544 |
| SLC25A15 | 129 | chr13 | 40799186-40799314 |
| SPG7 | 126 | chr16 | 89524046-89524104, 89554476-89554542 |
| no gene overlap | 14951 | - | - |
| Gene | Bases | Chromosome | Coordinates (hg38) |
| SPG7 | 59 | chr16 | 89524046-89524104 |
Gaps checked by visual inspection of raw data:
| Gene | Bases | Chromosome | Coordinates (hg38) |
| CYP7B1 | 28 | chr8 | 64615713-64615740 |
| CYP7B1 | 3 | chr8 | 64616216-64616218 |
gaps remaining
| Gene | Bases | Chromosome | Coordinates (hg38) |
| CYP7B1 | 212 | chr8 | 64624393-64624515, 64798456-64798544 |
| SLC25A15 | 129 | chr13 | 40799186-40799314 |
| SPG7 | 67 | chr16 | 89554476-89554542 |
| no gene overlap | 14951 | - | - |
Percentage of regions with depth <20 after closing gaps: 15359
Percentage gaps after closing gaps: 5.66%
Gap report based on exons of target region ± 20 Bases
Bases: 5975
Percentage of regions with depth <20: 528
Percentage gaps: 8.84%
Genes without gaps:
Genes with incomplete coverage (missing bp in brackets): CYP7B1 (263), SLC25A15 (129), SPG7 (136)
Details regions with depth <20:
| Gene | Bases | Chromosome | Coordinates (hg38) |
| CYP7B1 | 263 | chr8 | 64615713-64615740, 64616216-64616218, 64624383-64624515, 64798446-64798544 |
| SLC25A15 | 129 | chr13 | 40799186-40799314 |
| SPG7 | 136 | chr16 | 89524046-89524104, 89554466-89554542 |
| Gene | Bases | Chromosome | Coordinates (hg38) |
| SPG7 | 59 | chr16 | 89524046-89524104 |
Gaps checked by visual inspection of raw data:
| Gene | Bases | Chromosome | Coordinates (hg38) |
| CYP7B1 | 28 | chr8 | 64615713-64615740 |
| CYP7B1 | 3 | chr8 | 64616216-64616218 |
gaps remaining
| Gene | Bases | Chromosome | Coordinates (hg38) |
| CYP7B1 | 232 | chr8 | 64624383-64624515, 64798446-64798544 |
| SLC25A15 | 129 | chr13 | 40799186-40799314 |
| SPG7 | 77 | chr16 | 89554466-89554542 |
Percentage of regions with depth <20 after closing gaps: 438
Percentage gaps after closing gaps: 7.33%
Coverage statistics of RNA sample
Number of reads: 10.99 Mio
Average sequencing depth: 15.85
Average sequencing depth of housekeeping genes: 263.87
Covered genes: 136985
OMIM gene and phenotypes
| Gene | gene MIM | phenotype MIM | phenotype | preferred phenotype |
| CYP7B1 | 603711 | 270800 | Spastic paraplegia 5A, autosomal recessive, 270800 (3) | yes |
| SLC25A15 | 603861 | 238970 | Hyperornithinemia-hyperammonemia-homocitrullinemia syndrome, 238970 (3) | no |
| SPG7 | 602783 | 607259 | Spastic paraplegia 7, autosomal recessive, 607259 (3) | no |
Polygenic Risk Scores (PRS)
| Trait | Publication | Score | z-score | population (estimated from NGS) |
| Breast Cancer | Mavaddat N et al. Am J Hum Genet (2018). doi:10.1016/j.ajhg.2018.11.002 | -0.2773 | 0.240 | European |
A validated risk estimation program must be used to judge the clinical importance of a PRS, e.g. CanRisk.org for breast cancer. The ethnicity of the patient must also be considered.


Welcome
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Humans and machines
Let's find out the best way to learn programming and spoken languages
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WITHOUTFRAMEWORK


The COVID-19 outbreak in Japan has left hundreds of thousands of university students in a chaotic situation. Lectures that were supposed to start in April only recently began to be offered online. Part-time jobs that helped students to support themselves have vanished, while the incomes of many of their parents have dwindled since the government declared the state of emergency in April.
Annamaria, a 27-year-old Slovakian student of environmental engineering at one of Japan’s top universities, worries she may not be able to submit her thesis before the deadline if she doesn’t return to Japan by September. When she left Japan on March 3 to visit her family during her spring break, Slovakia had no reported COVID-19 infections and Japan had not yet seen.


XR not found
Squeeze = show/hide controllers A/X = forward 15 second B/Y = back 15 second
Click 'Enter VR' to see content


This is an example of rendering animation using only CSS3.
There are three separate animations - pulse (stars), glow (Sun), and rotate (Earth, Moon).


--- layout: post title: Fitbit Commercial categories: [] tags: - fitbit - geek - health status: publish type: post published: true meta: _original_post_id: '' _original_import_author: John Duprey author: ---
A little bit of fitbit marketing..


| Days of the week: | Sunday | Monday | Tuesday | Wednesday | Thursday | Friday | Saturday |
|---|---|---|---|---|---|---|---|
| English: | sunday | munday | tunday | wunday | thunday | funday | sanday |
| French: | samday | monday | tuesdey | wennsday | thirstday | fridé | samedi |
| First Name | Middle Name | Last Name |
|---|---|---|
| Mike | Middle | Last | Final | Thoughts |


Pirate (ARRR) is a cryptocurrency that solves the issue of financial privacy on the blockchain through forced anonymous transactions. Protect your wallet and transactions with Pirate’s completely anonymous network. With forced private transactions, your privacy cannot be compromised by another users’ activity on the network. If you wish to learn more, please join the official Pirate Discord at https://pirate.black/discord/ or message FishyGuts#5085, who will be happy to help out.
Komodo Insight.   I will mine. I'm not seeing much buy/sell activity(edited)
ComputerGenie 👴👴👴29-Sep-18 02:08 AM
good, I didn't want to split off 1k anyway
ch6ris29-Sep-18 02:09 AM
what a great markermaker you are
2.0
ComputerGenie 👴👴👴29-Sep-18 02:10 AM
I'm just going with what the market bears, same as any businesman
wookie29-Sep-18 02:10 AM
@maki when you select activate coin the pull down menu should have pirate somewhere near the bottom
blackjok3r29-Sep-18 02:11 AM
bussinessmen are eveil piles of
ch6ris29-Sep-18 02:11 AM
fair enough
blackjok3r29-Sep-18 02:11 AM
I hate profiteers
People need to stop doing it
make the world a nice place to live in
1
ch6ris29-Sep-18 02:11 AM
that's what religion was supposed to do
1
maybe we should purge. get out that anger.
ComputerGenie 👴👴👴29-Sep-18 02:13 AM
bussinessmen are eveil piles of
Said every broke bastid that can't earn $1, ever
ch6ris29-Sep-18 02:14 AM
here we go...
ComputerGenie 👴👴👴29-Sep-18 02:14 AM
Don't hate the player, hate the game
blackjok3r29-Sep-18 02:14 AM
I mean we set out here to create a new system that stopped jewish people fucking everyone over by printing as much money as they can and all the other things they do, and all people do its use it, to do the same thing... really losing faith in humainity here
I do all my work for free, and seem to get plenty of donations along the way
thats how it shoudl work
ComputerGenie 👴👴👴29-Sep-18 02:15 AM
@blackjok3r have another , your inner racist isn't fully shining through yet
blackjok3r29-Sep-18 02:16 AM
Hvent had any yet, but I will start soon
maki29-Sep-18 02:16 AM
@wookie thanks
ch6ris29-Sep-18 02:16 AM
remember tazo's. oh i member(edited)
gt29-Sep-18 02:16 AM
should probably keep racist comments down in an open community
ComputerGenie 👴👴👴29-Sep-18 02:17 AM
I do all my work for free, and seem to get plenty of donations along the way
thats how it shoudl work
Donate me 50 ASICs and I'll stop selling on the open market
blackjok3r29-Sep-18 02:18 AM
I dont understand the rasist angle
maybe i should ahve said bankers
sorry
words are interchangeble there in my mind
seems all bankers are jewish...
but maybe not all jewish people are bankers
sorry guys
ComputerGenie 👴👴👴29-Sep-18 02:18 AM
only in Israel(edited)
ch6ris29-Sep-18 02:18 AM
I don't live in america so not the case for me.
blackjok3r29-Sep-18 02:19 AM
I live in australia, and it def the case here
ch6ris29-Sep-18 02:19 AM
what are you talking about.
I'm in the same country.
blackjok3r29-Sep-18 02:19 AM
we are just the same as USA we dont own our country either
we cant even vote in a PM
they just change the guy to whoever they like
ch6ris29-Sep-18 02:19 AM
mr scotty.
blackjok3r29-Sep-18 02:19 AM
after the election
ch6ris29-Sep-18 02:20 AM
yeah yeah. this could go on and on. I didn't think there was a very big jewish community here. maybe your right
gt29-Sep-18 02:20 AM
the world would be much easier to deal with if there were such things as an overarching conspiracy like you’re insinuating
ch6ris29-Sep-18 02:20 AM
purge time
blackjok3r29-Sep-18 02:22 AM
well... MR Scotty's first directive after gaining office, was to change all of our defense force personell to mandatory weapons retraining every 3 months regardless of deployment status... so maybe thats gonna happen sooner than we think
My best friend is in the Navy, he called me to tell me that a few weeks ago btw... I dont think its been reported anywhere
ch6ris29-Sep-18 02:23 AM
He is a religious doughbag who shoulden't be running the country I agree.
1
He won't last very long. But seriously Australian politics?

 You can't know for sure.
cleanse just in case.
1
bishop29-Sep-18 02:29 AM
3
1
blackjok3r29-Sep-18 02:29 AM
Genie I know your not rich... your twisting words
or should that be selecting words(edited)
ComputerGenie 👴👴👴29-Sep-18 02:30 AM
@ch6ris My life isn't entirely agnostic, but I live with $5-12k USD worth of monthly mining bills (separate from the massive amount I've spent on PIRATE) you can pay anytime you want
blackjok3r29-Sep-18 02:30 AM
this ben good chat, Im off for the day or 2. Time for a break. Have fun all.


I’ve been waiting a loooong time before unleashing my (very reduced) arduino skills in order to build something wicked.
Arduino is great for learning and… for building THAT CRAZY IDEA.
First idea was about using solar energy with arduinos but since I work at night… I think I’ll have to postpone that one a little bit.
From all the arduinos the one that really ticks my box is the lilypad. Yup, the wearable arduino is the one I’ve been more willing to lay my hands on.
So, what is the project about?
Well, I like cycling and I like gadgets… and if there’s something that a bicycle doesn’t have is a proper signaling system, so this is my idea: A jacket that will have a signaling/messaging system.
I know, there are some projects already out there trying to achive having a more secure cycle ride, but they are not very usable.
My efforts are not making something that works. My efforts are aimed to build something usable. Something useful. Something beautiful.
So far I’m experimenting with arduino and the Easy VR Shield. The idea is very simple: you give voice commands to your jacket like “RIGHT” or “LEFT” and the jacket will light up a << sign for a few seconds.
That’s what people would call an MVP, then, of course, there’s room for more fancy stuff like displaying messages to our fellow drivers… but this will come later, for now, let’s get the prototype working.
Anyway, I need to find a nice name for the project so, if you have a good idea for it, share it with me, please


Byte Frequency Analysis
Cross Corelation Analysis
File Header/Trailer Analysis
Byte Frequency Distribution for MIME Types


{%extends "confreg/confadmin_base.html" %} {%block title%}Cross conference emails{%endblock%} {%block layoutblock%}
| Sent by | {{email.sentby}} |
|---|---|
| Sent at | {{email.sentat}} |
| Subject | {{email.subject}} |
| Text | {{email.text}} |
| Included |
|
| Excluded |
|
| Recipients |
|


Press Releases
Team India probables for ICC CWC 2015 announced
The 30-member list features Samson, Manish and Kuldeep
The biggest news is that 5 heroes (Yuvraj Singh, Gautam Gambhir, Virendra Sehwag, Zaheer Khan, Harbhajan Singh) from World Cup 2011 has not selected for upcoming World Cup that starting from february 2015.
MEDIA RELEASE
The All-India Senior Selection Committee met in Mumbai today and selected the probables for the Indian team to represent at the ICC Cricket World Cup to be played in Australia / New Zealand in Feb - March 2015
THE 30 PROBABLES ARE AS FOLLOWS
MS Dhoni, Shikhar Dhawan, Rohit Sharma, Ajinkya Rahane, Robin Uthappa, Virat Kohli, Suresh Raina, Ambati Rayudu, Kedar Jadhav, Manoj Tiwary, Manish Pandey, Wriddhiman


PCL Cache is a portable caching framework, converting the caching classes in Q42.WinRT to a fully portable implementation using PCLStorage for file IO.
The source code is available on GitHub, and you can find the package on NuGet.
```cs
```


I never did a day's work in my life, it was all fun.
-Thomas Edison
Brian Muthomi
Javascript Full-Stack Developer
I'm a full stack JavaScript developer and a mobile web specialist. I love building apps that make people more efficient in their tasks. I am currently working on an application that enables people to buy construction materials through their phones and get them delivered on site.
Projects
Niyaleo
Niyaleo is a todo app with a task repository so you can place tasks you are not ready to get started on in one places
Currency converter
This is a project built for the google africa scholarship challenge.
Contact me
Will be glad to here from you
You can also reach me through my email<EMAIL_ADDRESS>See other stuff I work on my github.


| View source on GitHub |
TensorServingInputReceiver
A return type for a serving_input_receiver_fn.
tf.compat.v1.estimator.export.TensorServingInputReceiver
tf.compat.v2.estimator.export.TensorServingInputReceiver
This is for use with models that expect a single Tensor
or SparseTensor
as an input feature, as opposed to a dict of features.
The normal ServingInputReceiver
always returns a feature dict, even if it
contains only one entry, and so can be used only with models that accept such
a dict. For models that accept only a single raw feature, the
serving_input_receiver_fn
provided to Estimator.export_saved_model()
should return this TensorServingInputReceiver
instead. See:
https://github.com/tensorflow/tensorflow/issues/11674
Note that the receiver_tensors and receiver_tensor_alternatives arguments
will be automatically converted to the dict representation in either case,
because the SavedModel format requires each input Tensor
to have a name
(provided by the dict key).
The expected return values are:
features: A single Tensor
or SparseTensor
, representing the feature
to be passed to the model.
receiver_tensors: A Tensor
, SparseTensor
, or dict of string to Tensor
or SparseTensor
, specifying input nodes where this receiver expects to
be fed by default. Typically, this is a single placeholder expecting
serialized tf.Example
protos.
receiver_tensors_alternatives: a dict of string to additional
groups of receiver tensors, each of which may be a Tensor
,
SparseTensor
, or dict of string to Tensor
orSparseTensor
.
These named receiver tensor alternatives generate additional serving
signatures, which may be used to feed inputs at different points within
the input receiver subgraph. A typical usage is to allow feeding raw
feature Tensor
s downstream of the tf.parse_example() op.
Defaults to None.
__new__
@staticmethod __new__( cls, features, receiver_tensors, receiver_tensors_alternatives=None )
Create new instance of TensorServingInputReceiver(features, receiver_tensors, receiver_tensors_alternatives)
features
receiver_tensors
receiver_tensors_alternatives


Delete
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selection
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{{route.distance}}
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{{route.avg_speed}} min/Km


Making of Twins
created by Juergen Specht
Return to the movie page
Return to CyberZoo Homepage
page last updated 13 October 1997


SDL
create-window-and-renderer
external
(λ [Int, Int, Int, (Ptr (Ptr SDL_Window)), (Ptr (Ptr SDL_Renderer))] ())
draw-texture
defn
(λ [(Ptr SDL_Renderer), (Ptr SDL_Texture), (Ref SDL_Point)] ())
(draw-texture rend texture point)
draw-texture-centered
defn
(λ [(Ptr SDL_Renderer), (Ptr SDL_Texture), (Ref SDL_Point)] ())
(draw-texture-centered rend texture point)
render-copy-ex
external
(λ [(Ptr SDL_Renderer), (Ptr SDL_Texture), (Ptr SDL_Rect), (Ptr SDL_Rect), Double, (Ptr SDL_Point), SDL_RendererFlip] ())