Meningitis
Executive summary
Introduction
Meningitis is defined as inflammation of the pia and arachnoid meninges and the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord. The main infectious causes are viral, bacterial and fungal.
Meningitis is classified clinically as either acute or chronic. Acute meningitis occurs within hours or days, whereas chronic meningitis evolves over weeks. Acute meningitis is classified as
· aseptic (which is mostly viral in origin) or
· septic or pyogenic which is caused by bacteria.
Chronic meningitis is a complex entity with both infectious and noninfectious causes.
Target users
· Doctors
Target area of use
· Ward
Key areas of focus / New additions / Changes
This guideline addresses the management of the infective causes of meningitis in children and in adults. It provides advice on empirical antibiotic therapy.
The treatment of infective chronic meningitis has been added to this guideline and the management of meningitis in the immunocompromised has been adopted in this new version.
Antibiotic therapy is for two weeks at least.
Limitations
None.
Pathogens
1) Bacterial:
|
Age range |
Organism |
Site of entry |
Predisposing conditions |
|
All ages |
Neisseria meningitidis |
Nasopharynx |
Usually none, rarely complement deficiency |
|
All ages |
Streptococcus pneumoniae |
Nasopharynx, direct extension across skull fracture, or from contiguous or distant foci of infection |
All conditions that predispose to pneumococcal bacteremia, fracture of cribriform plate, cochlear implants, cerebrospinal fluid otorrhea from basilar skull fracture, defects of the ear ossicle |
|
All ages |
Coagulase-negative staphylococci |
Foreign body |
Surgery and foreign body, especially ventricular drains |
|
All ages |
Staphylococcus aureus |
Bacteremia, foreign body, skin |
Endocarditis, surgery and foreign body, especially ventricular drains; cellulitis, decubitus ulcer |
|
Older adult (>50yrs) and neonates |
Listeria monocytogenes |
Gastrointestinal tract, placenta |
Glucocorticoids, Transplantation (especially renal transplantation), Pregnancy, Liver disease, Alcoholism, Malignancy |
|
Older adults and neonates |
Gram-negative bacilli |
Various |
Advanced medical illness, neurosurgery, ventricular drains, disseminated strongyloidiasis |
|
Adults; infants and children if not vaccinated |
Haemophilus influenzae |
Nasopharynx, contiguous spread from local infection |
Diminished humoral immunity |
2) Viral:
A number of viruses produce aseptic meningitis including enteroviruses, herpes simplex virus (HSV), human immunodeficiency virus (HIV), West Nile virus (WNV), varicella-zoster virus (VZV), mumps, and lymphocytic choriomeningitis virus (LCM).
3) Chronic meningitis:
|
Age range |
Organism |
Site of entry |
Predisposing conditions |
|
All ages |
Mycobacterium tuberculosis |
Pulmonary TB |
Acute complication of pulmonary TB or as a reactivation of extra pulmonary TB. HIV significantly increases the risk. |
|
All ages |
Cryptococcus neoformans |
|
CD4 counts <100 cells/mm3. |
Presenting symptoms and signs
The main clinical features of acute bacterial meningitis are headache, fever and meningism. When this triad is accompanied by alteration in consciousness or seizures, the diagnosis is usually not in doubt. Other symptoms include photophobia, nausea, vomiting, backache and lethargy. Progression occurs rapidly over 1-3 days but a smaller number may have an acute fulminant course lasting hours. However patients with HIV infection may present with only one or two of these main features.
TB Meningitis is a difficult condition to diagnose and confirm clinically. The clinical features are those of slowly progressive. Constitutional TB symptoms including fever, night sweats, weight loss and malaise may be present for a week or more early on but these may also be absent or are not specific for TB. The main neurological symptoms suggestive of TB meningitis are headache, nausea, vomiting, irritability, behaviour change and meningism of gradual onset usually for a period of one week or usually longer in adults. However, headaches may be less prominent in children, fever may be absent in 10-20% of adults and the signs of meningitis are generally less prominent as compared to acute bacterial meningitis.
Examination findings
Management
Investigations:
1) Blood culture are often positive and can be useful in the event that cerebrospinal fluid (CSF) cannot be obtained before the administration of antimicrobials. Approximately 50 to 90 percent of patients with bacterial meningitis have positive blood cultures.
2) Lumbar puncture (LP) is the key investigation and is an overall simple and very safe test.
*CONTRAINDICATIONS- Increased intracranial pressure; Thrombocytopenia or other bleeding diathesis; Cardiopulmonary instability; Soft tissue infection at the puncture site.
|
|
Acute bacterial meningitis |
Tuberculous |
Cryptococcal |
Viral |
|
Appearance |
cloudy, purulent |
yellow/cloudy |
clear/cloudy |
Clear (cloudy) |
|
Cell/mm3 |
high >2000/mm3 neutrophils |
increased 50-500/mm3 lymphocytes |
normal/increased 0-100/mm3 lymphocytes |
normal/increased 0-500/mm3 lymphocytes |
|
Glucose (n=> 50% of plasma level) |
very low/absent <1mmol/L |
low |
normal/low |
normal |
|
Protein (n=< 0.5 mg/l) |
elevated 1-2 mg/L |
high/very high 1-5 mg/L |
normal/elevated 0.5-2 mg/L |
normal/elevated 0.5-1 mg/L |
|
Diagnosis confirmed |
Gram stain & culture |
ZN stain & culture |
India ink stain/ Cryptococcal Antigen/Culture |
PCR |
Treatment:
Bacterial — The mainstay of management of ABM is prompt diagnosis and early treatment with antimicrobials. It is important that antimicrobials should be given straight away (within 20-30 mins of first seeing the patient) and not to delay treatment because of ongoing investigations including a LP. In adults ceftriaxone is now the drug of first choice. In adult, the dose is 4g/day while in children, 100 mg/kg/day IV (maximum dose 4 g/day) in 1 or 2 divided doses. The use of steroids in the treatment of ABM in adults is currently not recommended in Africa.
Viral — Most patients with viral meningitis require only supportive care. Patients who are elderly, immunocompromised, or have received antibiotics prior to presentation may be considered for empiric antibacterial therapy for 48 hours, even if viral meningitis is the suspected diagnosis.
If HIV is a diagnostic consideration, then blood testing for HIV RNA and HIV antibody should be performed.
If aseptic meningitis due to HSV is suspected, empiric therapy with intravenous acyclovir (for adult and children: 10-15 mg/kg every 8 hours, for neonates: 60 mg/kg per day divided every 8 hours) can be considered for hospitalized patients.
TB — All four TB drugs are given for the first 2 months after which isoniazid and rifampicin are continued usually for another 10 months. In practice the standard total period of treatment is 12 months for tuberculous meningitis and longer for tuberculoma.
In general, glucocorticoid therapy is warranted for all patients (including those with HIV) with convincing epidemiologic or clinical evidence for tuberculous meningitis. The regimen consists of oral prednisolone: children: 2 to 4 mg/kg per day; adolescents and adults: 60 mg/day. Administer initial dose for two weeks, then taper gradually over the next six weeks (ie, reduce daily dose by 10 mg each week); total duration is approximately eight weeks.
Starting ART is recommended after the first 2 weeks of TB meningitis treatment in HIV.
Cryptococcal — The treatment of Cryptococcal meningitis in Africa is mostly based on fluconazole alone. There are three phases: induction phase, consolidation phase and maintenance phase. In the induction phase, fluconazole (1200 mg orally per day) may be administered for at least 10 weeks or until CSF culture results are negative, followed by consolidation therapy with fluconazole (400 mg orally daily). The maintenance or prophylaxis phase uses fluconazole 200 mg daily until the CD4 count is >200/mm3 for >6 months. Multiple lumbar punctures may be needed to relieve raised ICP.
A delay in initiation of ART until at least 4 weeks after the start of the treatment phase appears to have a better outcome in fluconazole treated patients. Long-term mortality in CM is high (>50%) even with ART.
Unclear etiology — When it is not clear whether the patient has a viral or bacterial process, we recommend empirical antibiotics after obtaining blood and CSF cultures or observation with repeat lumbar puncture in 6 to 24 hours. If the patient is symptomatically improved and culture results are negative, then antibiotics can generally be stopped without a repeat LP. However, repeat LPs may be indicated in patients with persistent symptoms who do not have a clear diagnosis.
|
|
Acute bacterial meningitis |
Tuberculous |
Cryptococcal |
HSV |
|
Medication dose (in children) |
Ceftriaxone 4 g (100 mg/kg) OD |
1)TB4 2)Prednisolone |
Fluconazole 1)1200 mg (18 mg/kg) OD 2)400 mg (6 mg/kg) OD 3)200 mg (3 mg/kg) OD |
Acyclovir 10-15 mg/kg TDS (neonate: 60 mg/kg divided every 8 hours) |
|
Duration (in children) |
2 weeks (3 weeks) |
1) 12 months 2) 2 weeks, then taper gradually over the next six weeks |
1)10 weeks 2)8 weeks 3)until the CD4 count is >200/mm3 for > 6 months |
2 weeks |
Key Issues for Nursing care
· Deterioration in clinical status can occur rapidly, so frequently assess the patient's neurologic status, especially level of consciousness and vital signs. Report new focal signs immediately.
· Try to minimize increases in the patient's ICP. Appropriate measures may include keeping the patient's head of bed elevated to 30 degrees, keeping the head midline, minimizing suctioning, using sedation, keeping the room quiet and dark, and avoiding hypercapnia.
· Patients with bacterial meningitis may develop dehydration, shock, syndrome of inappropriate secretion of antidiuretic hormone, and/or intracranial hypertension. Closely monitor for fluid and electrolyte imbalances.
· Analgesics may be required to treat headache. Darkening the room may help if the patient complains of photophobia.
· The patient's hearing should be assessed before discharge because hearing loss is a common late complication of bacterial meningitis.
· Keep in mind that because N. meningitidis is easily spread from person to person, secondary cases need to be prevented. Suspected meningococcal disease should be reported to the local public health department. People in close contact with an infected person should receive chemoprophylaxis with single dose of oral ciprofloxacin 500 mg daily (adults only) or oral rifampicin 10 mg/kg twice daily (up to 1200 mg/day) for 4 days
References
NEUROLOGY IN AFRICA; William Howlett: Updated Oct 17,.2018 (First published: Aug 16, 2012)
Up To Date: Central nervous system tuberculosis: last updated: Oct 26, 2018.
Up To Date: Epidemiology of bacterial meningitis in adults: last updated: Sep 26, 2018.
Up To Date: Lumbar puncture: Indications, contraindications, technique, and complications: last updated: Sep 26, 2018.
Up To Date: Fluconazole: Drug information
Up To Date: Aseptic meningitis in adults: last updated: Sep 26, 2018.
Up To Date: Clinical features and diagnosis of acute bacterial meningitis: This topic last updated: Aug 30, 2018
Fire up to beat the threat of bacterial meningitis; Miller A, Nursing2013: December 2013 - Volume 43 - Issue 12 - p 52,58–58
|
Written by: |
Name: Eriko Ikeda |
Date: 29 October 2018 |
|
Reviewed by: |
Name: Fatai Akemokwe |
Date: 07 November 2018 |
|
Version: |
Change history: |
Review due date: |
|
1.0 |
New document |
|
|
2.0 |
Rewritten to include the management of chronic meningitis and adapted to the new template |
31 January 2021 |
|
2.1 |
Executive summary added |
31 January 2021 |
|
Review Comments (if applicable) |
|
|


BIGNASim is a comprehensive database system and analysis portal holding nucleic acids MD trajectories and analyses. The database allows direct access to trajectory data, information about the structure and MD simulation metadata, together with a complete set of analyses performed. Additionally, the database is provided with a flexible NAFlex-based engine allowing users to perform their own analysis pipelines.


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Utility classes which are needed by the PXLab runtime core classes.
The classes in this package do not depend on the package de.pxlab.pxl.
de.pxlab.pxl


Strictly stars ditch lace and sequins for leopard print and sunnies in Blackpool
The contestants are in the brightly lit English city for a weekend of celebrations and dance routines as Strictly takes over the Blackpool Tower Ballroom
by Irishmirror.ieThe stars and professionals of Strictly Come Dancing have descended on Blackpool for the annual live episode from the iconic Blackpool Tower Ballroom - and they all look to be in high spirits indeed.
Seven lucky celebrities have made it thus far in the 2019 competition - and are joined by their dance partners for what will no doubt be a breathtaking night of fancy footwork.
Former England footballer Alex Scott, 35, comedian Chris Ramsey, 33, EastEnders star Emma Barton, 42, CBBC presenter Karim Zeroual, 20, soap hunk Kelvin Fletcher, 35, TV judge Michelle Visage, 51, and YouTube star Saffron Barker, 19, have all made it to the landmark episode.
And they are joined by respective dance partners Neil Jones, Karen Hauer, Anton du Beke, Amy Dowden, Oti Mabuse, Giovanni Pernice and AJ Pritchard for the big night.
Landing at the iconic Blackpool Tower Ballroom building on Saturday, the stars and were met by well wishers and Strictly superfans who embraced chilly weather for an up close look at the contestants.
And the stars of the show didn’t disappoint as they signed autographs and posed for selfies with the hordes of adoring fans.
Show host Tess Daly, 50, looked radiant (and decades younger than her age would suggest) as she arrived wrapped in a chic, grey, Louis Vuitton scarf and power suit.
American star Michelle (who is a judge on popular reality show Ru Paul’s Drag Race) showcased her absorption into UK culture by channelling her inner Pat Butcher and wearing a thigh leopard print coat.
While Anton Du Beke looked something like a Poundland version of Del Boy as he sauntered up in a wooden coat and a flatcap.
Karim and Amy were all smiles as they arrived together in puffy black jackets.
While adorable dance pro Oti fully embraced the Blackpool way of life as she arrived carrying a stick of rock and wearing an “I heart Blackpool” hoodie.
Dianne Buswell was impossible to miss as she sauntered up to the tower in an offensively bright orange coat that looked as comfortable and warm as a sleeping bag.
While married dance star Aljaž Skorjanec camped things up in a garish pair of Blackpool sunglasses.
Elsewhere, show judges Bruno Tonioli and Craig Revel-Horwood looked slightly harassed as they arrived ahead of Saturday night’s show.
Craig glared at photographers with a strained expression while dressed in black.
And Bruno scowled behind dark sunglasses as he marched into the iconic venue.
Strictly Come Dancing continues tonight, Saturday 16 November 2019, from 7:05pm on BBC One.


THE DEEP END OF THE OCEAN RATING: 6.5 / 10 --> So-so
For more reviews and movie trivia, visit http://www.joblo.com/
Based on the best-selling novel of the same name, this film recreates a nightmarish situation to which all parents could identify: the sudden disappearance of a child. Michelle Pfeiffer takes on the role of the absent-minded mom who loses the boy, while Treat Williams portrays the steadfast and patient husband.
PLOT: Regular family of mom, dad and three kids. Mom takes trip with kids, and leaves her two sons alone in a hotel lobby for a few minutes. When she returns, the younger boy has disappeared. They try to find him but to no avail. Nine years later, the boy unknowingly shows up at her front porch soliciting a lawn-mowing gig. His fingerprints are a match. Now, they must survive his return and their ongoing struggles to cope with their divergent feelings.
CRITIQUE: Take a TV movie of the week, add two dashes of a solid actress via Michelle Pfeiffer, an interesting, if not mostly given away by its own trailer, storyline, some hugs, some tears, and you've got yourself a film whose title still doesn't fully make much sense to me. Now despite me knowing exactly what was going to happen up until the halfway point of this movie, this film conquered the impossible, and still managed not to bore me too much. It did however lack the overall emotional authenticity for me to qualify it as a solid all-out dramatic piece of filmmaking. The acting was also a half-and-halfer with Pfeiffer pulling off an excellent mom going through all the obvious stages of grief and guilt-syndrome, while others like Whoopie Goldberg stuck out like a sore thumb (That's right, she plays Whoopie again!).
I also found the missing kid to be lacking much of the conviction needed for his complex role. His character always seemed indifferent and emotionless, and whether or not that was the actor's fault or that of the screenwriter, I didn't quite find his full-circle plight all that believable. Having said that, Jonathan Jackson playing the older brother was super in his role, and Treat Williams, well, Treat Williams continues his artistic trek to restore some much-needed legitimacy to his acting career. Mrs. JoBlo enjoyed this film much more than I did, but I suppose that was to be quite expected, considering the subject matter of the picture. All in all, I didn't think it was a bad movie, but did wonder about its need for giant screen presentation. The TV tube and a Sunday night would have been fine. All in all, it is Pfeiffer and Jackson that give this movie some worth, with the story never running into major boring moments (or any exciting ones for that matter), and qualifying this movie as a worthy candidate for a video rental. You might even want to check it out in the theatres, if you've been feeling sensitive of late, and want a good cry. That, or if you're really intrigued by its premise.
Little Known Facts about this film and its stars: The novel on which this film is based was endorsed by Oprah Winfrey's wonderful Book Club. In fact, it was the first book picked by the super-rich talk-show queen back in September of 1996. MORE COMING SOON...
Review Date: March 8, 1999 Director: Ulu Grosbard Writer: Stephen Schiff (based on novel by Jacqueline Mitchard) Producers: Michelle Pfeiffer and Kate Guinzberg Actors: Michelle Pfeiffer as Beth Cappadora, Treat Williams as Pat Cappadora, Whoopie Goldberg as Candy Bliss Genre: Drama Year of Release: 1999
Visit JoBlo's Movie Emporium http://www.joblo.com
(c) 1999 Berge Garabedian
The review above was posted to the
rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).
The Internet Movie Database accepts no responsibility for the contents of the
review and has no editorial control. Unless stated otherwise, the copyright
belongs to the author.
Please direct comments/criticisms of the review to relevant newsgroups.
Broken URLs inthe reviews are the responsibility of the author.
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Related links: index of all rec.arts.movies.reviews reviews


--- layout: post title: Bookmarks for February 23rd through March 1st tags: - authentication - backbone.js - bookmarklet - brew - database - debugging - defered - functional - gem - git - gui - haskell - installer - javascript - jquery - loading - management - mobile - mongodb - names - node.js - osx - rails - ruby - tumble - two-factor - variable - xcode status: publish type: post published: true meta: aktt_notify_twitter: 'no' ---
These are my links for February 23rd through March 1st:


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Hi meatbag, I'm Bender. Welcome to Mars Vegas. Let's play some Blackjack!
The goal of this game is to get as many points as possible but without going over 21 points, because then you will automatically lose!
Press the 'New Game' button to start a new round: you can ask for more cards from the deck using the 'Ask Card' button and stand whenever you want by pressing the 'Stop' button. Then it will be my turn to beat you! The first one to win 5 rounds will be the final winner.
These are the card values:
Do you think you can beat me?


Bienvenue 환영합니다 Bienvenido - ようこそ Welcome 歡迎光臨¶
AvantPy - Python with training wheels: executable pseudocode in any language.
Warning
This is pre-alpha software, currently in development. Currently, it is only tested from a local repository, and while it is available from pypi.org using pip, we do not test with such an installed version.
The code is available on Github
What is AvantPy?¶
AvantPy is a collection of dialects, each dialect being a superset of Python, designed to make it easier to learn programming concepts in a given human language.
Each dialect consists of a translations of most Python keywords in a given human language, supplemented by a few additional constructs intended to make some programming concepts easier to learn.
The current version includes four dialects: English, French and Spanish, as well as an UPPERCASE version of the English dialect. The translation currently done in these three dialects is subject to change; feel free to make suggestions for alternative to use, or contribute a new dialect.
AvantPy is a preprocessor, that takes a program written either totally or in parts in a given dialect, and converts it to standard Python prior to execution.
A syntactically valid program can include a mix of code written in normal Python and in a specific dialect. This is to ease the transition to learning Python.
AvantPy is written as a standard Python module/package meant to be usable with any “normal” Python environment. Thus, it could be included as a plugin for a given editor, or run with a standard Python interpreter from the command line.
AvantPy also includes a tool to convert programs written in a given dialect into standard Python, showing the differences between the two, thus helping motivated users to make the transition to using only standard Python.
It is also possible to translate valid programs from one dialect into another.
AvantPy also includes a custom REPL that can use any of the existing dialects.
Finally, AvantPy uses friendly-traceback to analyze Python tracebacks and translate them into easier to understand feedback for beginners.
Who is it for?¶
The main target audience is composed of students who do not know English and are learning programming for the first time, under the guidance of an instructor. It can also be helpful for students making the transition from block-based programming languages to text-based ones.
Executable pseudocode?¶
Python is often described as executable pseudocode. Once people have learned a few idiomatic expressions, like:
for variable in range(n):
translating pseudocode written in English into Python is usually very straightforward.
If the pseudocode is not written in English, the translation process is, at least initially, not as straightforward since an additional mental step is required by the translation from the original language into Python’s English.
Even though the number of Python keywords is small, for absolute beginners who are learning programming concepts (control flow structures, defining functions, etc.), being able to use a language that uses keywords easily understood in their own language can definitely facilitate the learning process. This is the approach taken by people using block-based environments (Scratch, Blockly, etc.) developed by educational experts to help students learn programming concepts.
Realistically, many students who learn computer programming as part of a formal course might never use programming again or, if so, it might not be for many years. As Mark Guzdial wrote:
People code for different purposes, with different ways of appropriating code. … Not everybody is going to be a professional software developer, and they don’t need to be.
And, he also wrote in a later blog post: something I very much agree with:
If we want people to program, make it easy. Remove the barriers. That’s what we’re about. [Note: I am using this quote in a different context than that of the blog post.]
Given enough time, beginners who have just learned programming and stop using it would likely forget most of the programming syntax they had learned. However I claim that they likely would understand and remember programming concepts better if they are first learning them in their native language. This is what AvantPy aims to do for them.
Contents¶
Todo
Give an example of how to do so.
(The original entry is located in C:\Users\andre\github\avantpy\docs\source\contribute.rst, line 69.)
Todo
This module needs to be documented properly
(The original entry is located in C:\Users\andre\github\avantpy\avantpy\gui.py:docstring of avantpy.gui, line 9.)


Google Maps adds branded location pins in navigation mode
Google says this makes it easier for users to add another destination on their planned route
by Aisha MalikGoogle Maps will soon start showing tiny branded location pins for stores and restaurants near you while in navigation mode.
The tech giant has been increasingly monetizing Maps through ads. The location pins in Maps recently started featuring a store’s logo in the standard mode, and now the logo will appear in navigation mode as well.
Google sees this as a way for users to add another destination on their planned route. Now, when you tap on a branded location, you have the option to add it as a stop.
“In the coming weeks, you’ll be able to feature your locations as users get directions to a destination. In just a few taps, they can add you as a convenient stop along their route to grab lunch, stop in for shopping, and more,” Google stated in a blog post.
For the holiday season, Google has allowed stores to create a visual catalogue to advertise their products on the Map app. To demonstrate the feature, Google has used Dunkin Donuts, which isn’t available in Canada.
The branded pins will be rolling out globally to both Android and iOS users in the next few weeks.
Image credit: Google
Source: Google Via: 9to5Google


Using VCS with IDE Projects
See Also
The IDE's VCS support enables developer groups to synchronize project-specific
metadata as well as the source files that make up their applications. Using
VCS, you can place project metadata, such as project properties files and Ant
build scripts, under version control.
- The physical location of each project in relationship
to the location of projects and libraries on its classpath must be exactly
the same on every machine the project is checked out to. If any references
are broken, the IDE displays a warning when you open the project. To avoid
broken references, it is advisable to ensure that the location of projects
in the VCS repository matches their location when they are checked
out to a local working directory.
IDE Project Metadata Files
Depending on project type, the IDE generates different metadata files and stores
them in the nbproject directory. The types of project metadata files
in the IDE include:
- nbproject directory
- project.xml
- build-impl.xml (standard projects only)
- genfiles.properties (standard projects only)
- project.properties (standard projects only)
- private directory (standard projects only)
- build.xml
- You should not place your private directory
into the VCS repository, as it contains information that is specific
to your system's IDE installation. The IDE automatically
ignores the private directory
when running VCS commands. In addition, you should not put your
dist or build directories
into the repository.
To place IDE project metadata under version control:
- Register the directory that contains the project as a VCS working directory.
For more information, see Setting
Up VCS.
- In the Projects window, right-click your project's node and choose Clean
Project to delete the build and dist directories.
- Add the project metadata to the VCS repository. If you are using CVS, for
example, open the Files window (Ctrl-2), right-click the application's topmost
node, and choose CVS > Add.
- In the Add dialog box, select Add All Local Files in Folder Contents and
select Add the Folder Contents Recursively. Click OK.
Note: the IDE automatically ignores the private directory
and any files that are already in the CVS repository.
- Commit the project metadata to the VCS repository. If you are using
CVS, right-click the topmost application node in the Files window and choose
CVS > Commit.
- Enter a message
describing your changes to the repository in the Commit dialog and click
OK.
The IDE uploads the new files to the repository and the VCS Ouput window
opens to display the progress.
Legal Notices


MY MANGA is a trifle I wrote one night to hold some manga translations I was doing, or planning on doing.
I wanted a simple and beautiful interface but one that would let readers concentrate on the manga page. I picked a few open fonts, three colours, and the new tools of the web, and hop! that was it. I hope you like it...
Nevermind that the title says BY ME FOR YOU, none of the manga hosted here are actually mine. Sure, I translated some of them, but that is nothing compared to the true genius of the authors.
Oh, and are you worried that I'm robbing the mangaka of their copyright? Be reassured: not here. Either I've got permission, or the work is free...


The first step of translating lambdas into bytecode is desugaring the lambda body into a method.
The simplest form of lambda expression to translate is one that captures no state from its enclosing scope (a stateless lambda):
The natural signature of the lambda is (Ljava/lang/String;)V
.
The compiler desugars the lambda body into a static(ACC_STATIC
) method whose signature is the natural signature,
and generates a name(lambda$test$0
) for the desugared body.
The other form of lambda expression involves capture of enclosing final (or effectively final) local variables,
and/or fields from enclosing instances (which we can treat as capture of the final enclosing this
reference).
Here, our lambda captures the final local variables bottom
and top
from the enclosing scope.
The signature of the desugared method will be the natural signature (Person)Z
with some extra arguments prepended at the front of the argument list.
The compiler has some latitude as to how these extra arguments are represented;
they could be prepended individually, boxed into a frame class, boxed into an array, etc.
The simplest approach is to prepend them individually:
Alternately, the captured values (bottom
and top
) could be boxed into a frame or an array;
the key is agreement between the types of the extra arguments as they appear in the signature of the desugared lambda method,
and the types as they appear as (dynamic) arguments to the lambda factory.
Since the compiler is in control of both of these, and they are generated at the same time,
the compiler has some flexibility in how captured arguments are packaged.
A lambda expression is said to be capturing if it either access instance variables of it's enclosing class or local variables (final or effectively final) from it's enclosing scope.
A non-capturing lambda doesn't use any variables from outside.
Non-capturing lambdas generally are considered more efficient than the capturing ones as they are evaluated only once.


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Package org.actioncontroller.meta
The meta-package contains annotations used on other annotations
to attach behavior to the annotations. The package consists of
Annotations
Apply these to specific annotations to specify their effect:-
HttpParameterMapping
annotates annotations used on parameters to specify how to populate the arguments in the context onf anApiHttpExchange
(andApiClientExchange
) -
HttpReturnMapping
annotates annotations used on methods to specify how to deal with a return value in the context of anApiHttpExchange
(andApiClientExchange
) -
HttpRouterMapping
annotates annotations used on methods to specify how to generateApiControllerAction
s from the methods
Factories
These are used when a controller is initialized to convert the class structure into a list of actions with mappers of parameters and return value.-
ApiControllerActionFactory
creates aApiControllerAction
from a method -
HttpParameterMapperFactory
creates mappers fromApiHttpExchange
to method invocation arguments -
HttpReturnMapperFactory
creates mappers from method invocation return valueApiHttpExchange
Mappers
These are used during a specific method invocation to convert from the HTTP values to the actual method invocation values.-
HttpParameterMapper
maps from anApiHttpExchange
to a method invocation argument -
HttpReturnMapper
maps from an method invocation return value toApiHttpExchange
-
HttpClientParameterMapper
maps from an method invocation arguments toApiClientExchange
-
HttpClientParameterMapper
maps from anApiClientExchange
to a method invocation return value
-
Interface Summary Interface Description AnnotationFactory ApiControllerActionFactory<ANNOTATION extends Annotation> HttpClientParameterMapper Returned byHttpParameterMapperFactory
to be used withApiClientClassProxy
to convert method arguments into HTTP request information.HttpClientReturnMapper Returned byHttpReturnMapperFactory
to be used withApiClientClassProxy
to convert HTTP response information into method return values.HttpParameterMapper Returned byHttpParameterMapperFactory
to be used withApiHttpExchange
to convert HTTP request information into method invocation arguments.HttpParameterMapperFactory<ANNOTATION extends Annotation> Implementations of this interface should be annotated on annotations used to convert HTTP requests into method invocation arguments, such asRequestParam
,PathParam
andUnencryptedCookie
HttpReturnMapper Returned byHttpReturnMapperFactory
to be used withApiHttpExchange
to method invocation return values to HTTP response information.HttpReturnMapperFactory<ANNOTATION extends Annotation> Implementations of this interface should be annotated on annotations used to convert method invocation return values to HTTP response information, such asContentBody
andSendRedirect
-
Annotation Types Summary Annotation Type Description HttpParameterMapping Attach parameter mapping behavior to an annotation.HttpReturnMapping Attach return value mapping behavior to an annotation.HttpRouterMapping Attach action generation behavior to an annotation.


{{ partial "hero-section" . }}
{{ partial "trusted-by-section" . }}
{{ partial "site-monitoring-section" . }}
{{ partial "api-monitoring-section" . }}
{{ partial "e2e-pr-section" . }}
{{ partial "alerting-section" . }}
{{ partial "results-section" . }}
{{ partial "workflow-section" . }}
{{ partial "testimonial-quote-full-width-1" . }}
{{ partial "testimonial-three-col-row" . }}
{{ partial "all-features" . }}
{{ partial "public-stats-section" . }}


{% extends 'base.html'%} {% block styles%} {{ super() }} {% endblock %} {%block content%}
Feel free to explore or even Read or Post
We welcome you to read posts or write


A football game between Yale and Harvard was delayed for nearly an hour after climate-change protesters stormed the field
by Akin Oyedele, Business Insider US- Climate-change activists interrupted an Ivy League football showdown between Yale and Harvard for nearly an hour on Saturday.
- They were calling on their respective universities to divest from fossil fuels, according to The New York Times.
- New Haven police and Yale University campus police were seen removing some of the protesters from the field.
- Visit Business Insider’s homepage for more stories.
A football game between Yale and Harvard was delayed for nearly an hour Saturday when climate-change protesters occupied the field.
The Ivy League showdown in New Haven, Connecticut stood at 15 – 3 to Harvard when activists took over the field with large banners, including one that read “Nobody wins: Yale & Harvard are complicit in climate injustice.”
According to The New York Times, the students were calling attention to their respective universities to divest their investments in fossil fuels.
According to live ESPN commentary, protesters arrived from different sides of the Yale bowl and sat in the middle of the field just before the second half began. As players from both teams retreated to their respective locker rooms, the crowd of protesters got bigger.
Campus police from Yale University and members of the New Haven police department were seen removing protesters.
The game resumed after a 48-minute delay.
The Times reported that there was a mixed reaction in the crowd, with some attendees booing and shouting that authorities drag the protesters off the field.
The matchup between both institutions has become one of college football’s most storied rivalries. Harvard won last year’s showdown 45-27.


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@composi/runtime:
Stop Program
Shutting Down a Program's Processes
When you run a program, that returns a function to shut down the program. In this snippet we have the simplest possible program. We run and capture its shutdown function and then stop it:
import { run } from '@composi/core'
// Run a simple program and capture its
// shutdown function in variable:
const endProgram = run({
init() {},
view(state, send) {},
update(state, msg, send) {}
})
// Three seconds later stop the program:
setTimeout(() => endProgram(), 3000)
When your program has effects that run timers, you'll want a way to make sure you can shut them down. Otherise, even after your app ends, the timers can keep running, consuming browser memory until it crashes. The following Codepen illustrates this problem. It has a setInterval to output the time by sending a message to an update action. The effect also logs a count to the console.
See the Pen @composi/core + runtime Clock-3 by Robert Biggs (@rbiggs) on CodePen.
Open the pen in its own window by clicking on the Codepen logo in the upper right. Then scrolldown to the bottom of the JavaScript panel. You'll see that when we run the program, we capture its return value in a variable stopProgram
. You can open by Codpen console in the bottom right by clicking and dragging it up. You'll see that the effect is also logging a count to the console. Now if you click in the console entry, type stopProgram()
and hit enter, the program will stop. You can tell because the the clock component is no longer update in the HTML. But you'll notice that the effect is still running independently of the program, logging the count in the console. The following image shows how to do this:
Having effects running after the program stops produces memory leaks. This is a big problem. But there is a simple solution to this, as explained next.
Done()
So far we have always talked about @composi/core runtime programs having three properties: init, view and update. This is the basics to have a program that can run. But you can also provide a fourth optional property: done()
. This method will get called when you stop your program. You can use it to do cleanup before the program stops. The done
method gets the application state passed to it.
import { run } from '@composi/core
const program = {
init() {},
view(state, send) {},
update(state, msg, send) {},
// Escape hatch:
done(state) {
// Clean up any running effects here...
}
}
// Start program:
const endProgram = run(program)
// Later:
endProgram()
// Stopping the program will first invoke the done() function,
// allowing us to clean up any running effects.
And here's our clock Codepen updated so that when we stop the program, the effect also stops. We've added a done()
method to our program to stop the setInterval. You can open the Codepen in its own window. Then open the console and enter stopProgram
. Now you'll see that the clock stops, and the setInterval also stops, no longer logging to the console.
See the Pen @composi/core + runtime Clock-4 by Robert Biggs (@rbiggs) on CodePen.


The link of spreadsheets: https://docs.google.com/spreadsheets/d/1vc45ww0DsxHquA40OYvw7pmXL8twzzvZtoHHgRK500E/pubhtml


Instructions
Welcome to the genome scoring page for the Archon Genomics XPrize presented by Express Scripts. Follow this how-to video and submit your sequences for scoring in 3 simple steps:
- Upload your variant file, and optionally a BED file of regions to score, to GenomeSpace.
- Login with your GenomeSpace username and password and select the uploaded files.
- Click Score and wait for your evaluation score.
Documentation
The scoring process uploads detailed results files and results to your GenomeSpace folder, giving you full access to correctly and incorrectly scored variants. Using GenomeSpace, you can easily import your files into external tools like Galaxy for further analysis.
For more information on the validation protocol implemented to generate the software and data found on this website, please visit the Validation Protocol Information Center.


Home
About Me
My Work
How To Reach Me
Hello!
I'm
Mahmudul Hasan
Bijoy
Web Designer | WordPress Theme Developer & Customizer


Liverpool Hammer Manchester City To Go Eight Points Clear At The Top Of The Premier League
by Robert RedmondLiverpool have gone nine points clear of Manchester City after hammering their rivals 3-1 at Anfield.
Jurgen Klopp’s team put City to the sword on Sunday afternoon, convincingly beating Pep Guardiola’s side thanks to goals from Fabinho, Mohamed Salah and Sadio Mane. Bernardo Silva scored a consolation goal for City.
Although there are still two-thirds of the season to play, Liverpool’s victory undoubtedly puts them in pole position in the title race. They are now eight points ahead of Leicester City and Chelsea in second and third place respectively and nine clear of champions City.
The game arguably hinged on a 30-second passage of play in the opening period of the first half. The ball struck Trent Alexander-Arnold’s arm in the Liverpool penalty area and Man City’s players appealed for a spot-kick, but the referee Michael Oliver waved play on. Klopp’s team mounted a counter-attack while their opponents protested. Sadio Mane’s cross bounced loose in the City box, Ilkay Gundogan’s tame clearance landed with Fabinho in space outside the penalty area. The Brazilian steadied himself and struck a wonderful shot beyond the diving Claudio Bravo to put Liverpool ahead after six minutes.
Seven minutes later, the home side doubled their lead. Salah headed home at the back post following a brilliant delivery from Andy Robertson, which was preceded by a stunning switch of play from Alexander-Arnold. City had some chances in the first half to reduce the deficit, but their patched up back-four were floundering against the relentless Liverpool front-three.
Bravo looked bereft of confidence in goal and would make an avoidable error for the third goal. Liverpool were evidently targeting Angelino at left-back, and neither John Stones nor Kyle Walker covered themselves in glory. Fernandinho, a veteran midfielder playing out of position, looked exactly that – a veteran midfielder playing out of position.
In midfield, Fabinho was magnificent for Liverpool, reading the game well and providing a solid base for Liverpool to spring attacks, he rarely lost the ball.
Alexander-Arnold was targeted as the home side’s weak-link in a Champions League tie between the teams in the spring of 2018. On Sunday, he was one of the most influential players on the pitch. Alexander-Arnold had the most touches (89), crosses (6) and key passes (2) of any Liverpool player. Upfront, Mane got a deserved goal, turning in Jordan Henderson’s excellent cross, with some help from Bravo in the City goal.
Bernardo made the scoreline more respectable with his strike in the second half but, despite some borderline decisions, Liverpool were worthy winners.
City’s patched-up backline, rather than the use of the VAR, proved the difference in the game as they were incapable of repelling Liverpool.
Here is how we rated the players:
Liverpool
Alisson – 7
Alexander Arnold – 8
Lovren – 7
Van Dijk – 7
Robertson – 7
Fabinho – 9
Henderson – 7
Wjnaldjum – 7
Mane – 8
Firmino – 7
Salah – 8
Substitutes
Milner – 6
Oxlade-Chamberlain and Gomez – N/A
Not on long enough to rate.
Man City
Bravo – 4
Walker – 5
Stones – 5
Fernandinho – 5
Angelino – 4
Rodri – 5
Gundogan – 5
De Bruyne – 7
Bernardo – 7
Aguero – 5
Sterling – 6
Substitutes
Gabriel Jesus – 5


SpaceInvoices
Constructor Summary
| Public Constructor | ||
| public |
constructor(apiToken: string, accountId: string, host: string) |
Member Summary
| Public Members | ||
| public get |
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| public get |
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| public get |
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| public get |
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Method Summary
| Public Methods | ||
| public |
switchAccountId(accountId: string) |


|
Contiki 2.5
|
The generic CTK widget structure that contains all other widget structures. More...
#include </cygdrive/e/share/contiki/core/ctk/ctk.h>
Data Fields | |
| struct ctk_widget * | next |
| The next widget in the linked list of widgets that is contained in the ctk_window structure. | |
| struct ctk_window * | window |
| The window in which the widget is contained. | |
| unsigned char | x |
| The x position of the widget within the containing window, in character coordinates. | |
| unsigned char | y |
| The y position of the widget within the containing window, in character coordinates. | |
| unsigned char | type |
| The type of the widget: CTK_WIDGET_SEPARATOR, CTK_WIDGET_LABEL, CTK_WIDGET_BUTTON, CTK_WIDGET_HYPERLINK, CTK_WIDGET_TEXTENTRY, CTK_WIDGET_BITMAP or CTK_WIDGET_ICON. | |
| unsigned char | w |
| The width of the widget in character coordinates. | |
| unsigned char | h |
| The height of the widget in character coordinates. | |
| union { | |
| } | widget |
| The union which contains the actual widget structure, as determined by the type field. |
The generic CTK widget structure that contains all other widget structures.
Since the widgets of a window are arranged on a linked list, the widget structure contains a next pointer which is used for this purpose. The widget structure also contains the placement and the size of the widget.
Finally, the actual per-widget structure is contained in this top-level widget structure.
| unsigned char ctk_widget::h |
The height of the widget in character coordinates.
Definition at line 463 of file ctk.h.
Referenced by ctk_draw_widget(), and ctk_draw_window().
| struct ctk_widget* ctk_widget::next |
The next widget in the linked list of widgets that is contained in the ctk_window structure.
| unsigned char ctk_widget::type |
The type of the widget: CTK_WIDGET_SEPARATOR, CTK_WIDGET_LABEL, CTK_WIDGET_BUTTON, CTK_WIDGET_HYPERLINK, CTK_WIDGET_TEXTENTRY, CTK_WIDGET_BITMAP or CTK_WIDGET_ICON.
Definition at line 455 of file ctk.h.
Referenced by ctk_draw_widget().
| unsigned char ctk_widget::w |
The width of the widget in character coordinates.
Definition at line 463 of file ctk.h.
Referenced by ctk_draw_widget().
| union { ... } ctk_widget::widget |
The union which contains the actual widget structure, as determined by the type field.
| struct ctk_window* ctk_widget::window |
The window in which the widget is contained.
Definition at line 447 of file ctk.h.
Referenced by ctk_draw_widget().
| unsigned char ctk_widget::x |
The x position of the widget within the containing window, in character coordinates.
Definition at line 451 of file ctk.h.
Referenced by ctk_draw_dialog(), ctk_draw_widget(), and ctk_draw_window().
| unsigned char ctk_widget::y |
The y position of the widget within the containing window, in character coordinates.
Definition at line 451 of file ctk.h.
Referenced by ctk_draw_dialog(), ctk_draw_widget(), and ctk_draw_window().


Contact Olalekan
Name
Email
Phone Number
Gender:
Male
Female
Select State
Lagos
Kwara
Oyo
Ekiti
Abuja
<-- Go to homepage
Ayanwale Oluwajuwon Olalekan - © Copyright 2021


class: center, middle # Bowling Kata --- # Setup (optional) Install Node.js and npm Create a package.json file and install mocha testing framework - npm init - npm install mocha --save-dev - npm install should --save-dev In a terminal window, run $ ./node_modules/.bin/mocha -w or $ mocha -w -C -R spec -G We will use http://mochajs.org/ for a test framework with shouldjs for BDD style assertions https://github.com/shouldjs/should.js --- # How to score Bowling http://en.wikipedia.org/wiki/Ten-pin_bowling ![Bowling Frame](http://upload.wikimedia.org/wikipedia/commons/thumb/6/61/Bowlstrike.PNG/330px-Bowlstrike.PNG) --- # External API - call roll for each roll - calculate score at the end - Assume good inputs (rolls always equal a full game) +--------------------+ | Game | | ------------------ | | + roll(pins : int) | | + score() : int | +--------------------+ --- #Gutter Game If all 20 rolls are 0 (gutter ball), the score should be 0 ```javascript for (i; i < 20; i ++) { game.roll(0); } game.score().should.equal(0); ``` --- #Simple games If all 20 rolls are 1 the score should be 10 ```javascript for (i; i < 20; i ++) { game.roll(1); } game.score().should.equal(10); ``` --- #Refactor Tests ## Always be stable! Use *Working Code* as tests for test code - Condense ``for`` loops into ``rollMany`` - Does this belong in Production code OR Test code? --- # Sum games If all rolls are less than or equal to 4, the score is the sum of the rolls - roll 3 10 times - roll 4 10 times - score should be 70 --- # Game with a single spare if we roll a 5 three times, and then all zeros the score should be 15 - roll a 5 3 times - roll 0 17 times - Score should be 15 You may need to remove this test, refactor, then procede --- #Possible object model .omodel[![object model](https://raw.github.com/pixelhandler/vagrant-dev-env/bowling/www/app/images/frame_class_next.png)] --- # Game with a single strike if we roll a Strike , then a 3 two times, and then all zeros the score should be 16 - roll a 10 one time - roll a 3 two times - Score should be 15 --- # Game with mixed strikes and spares Rolls: 3,4,6,4,7,1,4,5,10,4,6,10,10,10,5,5,3 = 169 --- # New Requirement! ## Bad input! - Throw an exception if score is called and you don't have a complete game --- # New Requirement! ## Per frame scoring - be able to call score at any time and return the current score - return known score if current frame cannot be scored --- # New Requirement! ## Kids bolwing - GutterBalls are not allowed - All rolls of 0 are re-rolled - Kid bolwing will be indicated by the caller (constructor arg?) --- # Klingon Bowling - Each frame gets 3 rolls - the lowest roll is considered ghojwI' (“student”) - two consective 0 rolls earns bIj (“punishment”) of -10 ## As for project orders (requirements, goals): Klingons do not deliver; we EXECUTE. For the glory of the empire!


Hello my website!
Using this project
This is the Glitch Hello Website project. You can use it to build your own site. Check out README.md in the editor for more info and next steps you can take!
content="https://cdn.glitch.com/43f6999f-ff4f-4a09-b9a1-1858e4c7befe%2FWelcome%20(1).png?v=1623038408175"
This is the Glitch Hello Website project. You can use it to build your own site. Check out README.md in the editor for more info and next steps you can take!
We like to do coding


--- layout: post permalink: clevercookie.html Tags: Array NameOfCoupon: Clever Cookie Cash Back Summary: See our Clever Cookie Coupon Code, Clever Cookie Rebate, Clever Cookie Promo Code, Clever Cookie Discount, Clever Cookie Coupon Cash Back Rebate here. MetaKeywords: Clever Cookie Coupon Code, Clever Cookie Rebate, Clever Cookie Promo Code, Clever Cookie Cash Back Rebate, Clever Cookie Discount, Clever Cookie Coupon Image: images/24219.jpg LinkURL: http://www.shareasale.com/r.cfm?b=193970&u=412002&m=24219 affiliate_url_link: http://www.icouponblog.com/jane.php?id=552 thesis_readmore: See the Clever Cookie Coupon thesis_thumb: http://www.icouponblog.com/tn.php?merchantURL=CleverCookie.com Title: Save 6% - Clever Cookie Coupon Code for CleverCookie.com. Clever Cookie Rebate & Discount thesis_description: Our Clever Cookie Discount Coupon Code for CleverCookie.com. We have the best Clever Cookie Rebate anywhere. thesis_keywords: Clever Cookie, Clever Cookie Coupon Code, Clever Cookie Discount, Clever Cookie Rebate product_name: Clever Cookie hop_url: http://www.icouponblog.com/hop.php?id=552 ---
Are you visiting a sick friend or do you need to cheer someone who’s feeling blue? You can cheer them up with a smiley face cookie or wish them a speedy recovery with a giant band aid cookie or give them an assortment of floral cookies in the shape of springtime bouquet. Get the cleverest cookie in town for your parties, baby shower, love and romance or any occasion from Clever Cookie an online cookie shop that has delicious and creative cookies and cookie gift baskets. Use our discount coupons to save a lot of money when you shop at Clever Cookie.
Clever Cookie is a delicious assortment of decorated cookies in many shapes and forms including your favorite cartoon characters, Sponge Bob, the Simpsons and Family Guy among others. Clever Cookie is an online shop for creative and delicious cookies that you can buy for a party, a baby shower. You can buy cookie gift baskets to say, thank you, get well soon, I love you or any other message. Clever Cookie has a large selection of cookies that you can choose from, according to the occasion. Visit Clever Cookie and bring a cheer, a smile on some recipient’s lips.
Clever Cookie is a great product. It is not only great tasting, but it allows you to be creative and unique in giving your gift or surprising your guests at a party. Everyone loves clever things; a clever cookie will definitely amuse people, cheer them up and pleasantly surprise them. They will feel special and loved that you took the time to bring them a unique present. Check out Clever Cookie and you will be so glad that you did! Use our coupons to get the best discounts.


How to create a solution / projects in Visual Studio
bake projects are Makefile projects (NMake). When creating a new project, you can just create a new Makefile project and add a Project.meta.
The recommended way is to use a script which comes with bake-toolkit:
Example: createVSProjects --version 2012 --rewrite_solution


formula.icc File Reference
(Revision: 6312)
Go to the source code of this file.
Functions | |
| Gecode::Formula | operator- (const Gecode::Formula &f) |
| Gecode::Formula | operator| (const Gecode::Formula &f, const Gecode::Formula &g) |
| Gecode::Formula | operator & (const Gecode::Formula &f, const Gecode::Formula &g) |
| Gecode::Formula | operator>> (const Gecode::Formula &f, const Gecode::Formula &g) |
| Gecode::Formula | operator== (const Gecode::Formula &f, const Gecode::Formula &g) |
Function Documentation
| Gecode::Formula operator- | ( | const Gecode::Formula & | f | ) | [inline] |
Definition at line 44 of file formula.icc.
| Gecode::Formula operator| | ( | const Gecode::Formula & | f, | |
| const Gecode::Formula & | g | |||
| ) | [inline] |
Definition at line 47 of file formula.icc.
| Gecode::Formula operator & | ( | const Gecode::Formula & | f, | |
| const Gecode::Formula & | g | |||
| ) | [inline] |
Definition at line 52 of file formula.icc.
| Gecode::Formula operator>> | ( | const Gecode::Formula & | f, | |
| const Gecode::Formula & | g | |||
| ) | [inline] |
Definition at line 57 of file formula.icc.
| Gecode::Formula operator== | ( | const Gecode::Formula & | f, | |
| const Gecode::Formula & | g | |||
| ) | [inline] |
Definition at line 62 of file formula.icc.


This theme has the following button styles built-in. You can always extend them to support your taste and theme!


This is the most basic eample with html template and events to be shown on the calendar.
These two options are used to show show and change months showAdjacentMonths
and adjacentDaysChangeMonth
. Edges of other months should be visible and clicking them should switch the month.
This example demonstrates multi-day events (12th - 17th, 24th - 27th).
This example demonstrates start and end constraints. (the 4th of this month to the 24th of this month).
The forceSixRows
option, which should make a six-row calendar regardless of the length of each month.
It Should highlight the last date you clicked on.


Packages¶
This section identifies the different VPP packages and describes their contents.
vpp¶
Vector Packet Processing executables. This is the primary package that must be installed to use VPP. This package contains:
vpp - the vector packet engine
vpp_api_test - vector packet engine API test tool
vpp_json_test - vector packet engine JSON test tool
vpp-lib¶
Vector Packet Processing runtime libraries. The ‘vpp’ package depends on this package, so it will always be installed. This package contains the VPP shared libraries, including:
vppinfra - Foundation library supporting vectors, hashes, bitmaps, pools, and string formatting.
svm - vm library
vlib - vector processing library
vlib-api - binary API library
vnet - network stack library
vpp-plugins¶
Vector Packet Processing plugin modules.
abf - Access Control List (ACL) Based Forwarding
acl - Access Control Lists (ACL)
adl - Allow/deny list plugin
af_xdp - AF_XDP Device Plugin
avf - Intel Adaptive Virtual Function (AVF) Device Driver
builtinurl - vpp built-in URL support
cdp - Cisco Discovery Protocol (CDP)
cnat - CNat Translate
crypto_ipsecmb - Intel IPSEC Multi-buffer Crypto Engine
crypto_native - Intel IA32 Software Crypto Engine
crypto_openssl - OpenSSL Crypto Engine
crypto_sw_scheduler - SW Scheduler Crypto Async Engine plugin
ct6 - IPv6 Connection Tracker
dhcp - Dynamic Host Configuration Protocol (DHCP)
dns - Simple DNS name resolver
dpdk - Data Plane Development Kit (DPDK)
flowprobe - Flow per Packet
gbp - Group Based Policy (GBP)
geneve - GENEVE Tunnels
gtpu - GPRS Tunnelling Protocol, User Data (GTPv1-U)
hs_apps - Host Stack Applications
http_static - HTTP Static Server
igmp - Internet Group Management Protocol (IGMP)
ikev2 - Internet Key Exchange (IKEv2) Protocol
ila - Identifier Locator Addressing (ILA) for IPv6
ioam - Inbound Operations, Administration, and Maintenance (OAM)
l2e - Layer 2 (L2) Emulation
l2tp - Layer 2 Tunneling Protocol v3 (L2TP)
l3xc - L3 Cross-Connect (L3XC)
lacp - Link Aggregation Control Protocol (LACP)
lb - Load Balancer (LB)
lisp - Locator ID Separation Protocol (LISP)
lldp - Link Layer Discovery Protocol (LLDP)
mactime - Time-based MAC Source Address Filter
map - Mapping of Address and Port (MAP)
marvell - Marvell PP2 Device Driver
mdata - Buffer metadata change tracker.
memif - Packet Memory Interface (memif) – Experimental
nat - Deterministic NAT (CGN)
nsh - Network Service Header (NSH)
nsim - Network Delay Simulator
oddbuf - Awkward chained buffer geometry generator
perfmon - Performance Monitor
ping - Ping (ping)
pppoe - PPP over Ethernet (PPPoE)
quic - Quic transport protocol
rdma - RDMA IBverbs Device Driver
srv6-ad - Dynamic Segment Routing for IPv6 (SRv6) Proxy
srv6-am - Masquerading Segment Routing for IPv6 (SRv6) Proxy
srv6-as - Static Segment Routing for IPv6 (SRv6) Proxy
srv6-mobile - SRv6 GTP Endpoint Functions
stn - VPP Steals the NIC (STN) for Container Integration
svs - Source Virtual Routing and Fowarding (VRF) Select
tlsmbedtls - Transport Layer Security (TLS) Engine, Mbedtls Based
tlsopenssl - Transport Layer Security (TLS) Engine, OpenSSL Based
tlspicotls - Transport Layer Security (TLS) Engine, Picotls Based
tracedump - Streaming packet trace dump plugin
unittest - C unit tests
urpf - Unicast Reverse Path Forwarding (uRPF)
vmxnet3 - VMWare Vmxnet3 Device Driver
vrrp - VRRP v3 (RFC 5798)
wireguard - Wireguard Protocol
vpp-dbg¶
Vector Packet Processing debug symbols.
vpp-dev¶
Vector Packet Processing development support. This package contains development support files for the VPP libraries.
vpp-api-python¶
Python binding for the VPP Binary API.
vpp-api-lua¶
Lua binding for the VPP Binary API.
vpp-selinux-policy¶
This package contains the VPP Custom SELinux Policy. It is only generated for Fedora and CentOS distros. For those distros, the ‘vpp’ package depends on this package, so it will always be installed. It will not enable SELinux on the system. It will install a Custom VPP SELinux policy that will be used if SELinux is enabled at any time.


{% extends 'base.html' %} {% block content %}
This tool shows you the diff between a draft's last AfC review and the current revision. This allows you to quickly see whether any substantive improvement has been made.
{% endblock content %} {% block extra_scripts %} {% endblock extra_scripts %}


YO Marathon
Varpaisjarvi FIN
Race Winners
(28 runnings)
06 Jul
2007
09 Jul
2004
04 Jul
2003
05 Jul
2002
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---
---
Notes: 1989 is believed to have been the inaugural year.
08 Jul
2016
3:06:08
Tuomo Hirvonen-2
3:51:54
Vuokko Honkanen (FIN)
02 Jul
2015
3:05:27
Tuomo Hirvonen (FIN)
3:59:20
Tenho Isala (FIN)
04 Jul
2014
3:05:48
Pauli Sonninen-2
3:37:13
Kaarina Lilja (FIN)
07
Jul
2013
3:07:20
Pauli Sonninen (FIN)
4:01:55
Anu Uhotoinen (FIN)
13 Jul
2012
3:03:58
Mihhail Kypriyarov (FIN)
3:34:07
Mari Ukkonen (FIN)
01 Jul
2011
2:52:59
Harri-Pekka Tikkanen-2
3:29:25
Minna Laakkonen (FIN)
02 Jul
2010
2:48:31
Sami Rosholm (FIN)
3:30:16
Anja Halonen (FIN)
03 Jul
2009
2:44:52
Harri-Pekka Tikkanen (FIN)
3:55:52
Ritva Vallivaara-Pasto (FIN)
05 Jul
2008
2:52;25
Markus Ryynanen (FIN)
3:38:30
Nataliya Andreyeva (RUS)
3:02:15
Hannu Kuosmanen-2
3:38:21
Riina Lindroos (FIN)
07 Jul
2006
2:58:22
Hannu Kuosmanen (FIN)
07 Jul
2005
2:53:16
Aleksandr Petrov-2
3:56:31
Niina Tallbacka (FIN)
3:47:19
Sergey Andreyev (RUS)
3:24:21
Paivi Siikavirta (FIN)
2:53:33
Aleksandr Petrov (RUS)
3:27:34
Orvokki Mayra (FIN)
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
1991
n/a
n/a
1990
n/a
n/a
1989
n/a
n/a
Most Wins
(1989/date)
Men
2
Aleksandr Petrov (RUS)
2003,2005
Hannu Kuosmanen (FIN)
2006-07
Harri-Pekka Tikkanen (FIN)
2009,2011
Pauli Sonninen (FIN)
2013-14
Tuomo Hirvonen (FIN)
2015-16
Women
No woman has
won more than once, according to available information.
Prize Money
No prize money has been awarded at this race.
Race Time Bias
Available data is insufficient to calculate the race time bias.
Competitive Level
Available data is insufficient to calculate the competitive level.
Quality Performances
Men No men under 2:20 Women No women under 2:50
Finishers
Year Men Women M+F 2016 11 7 18 2015 15 4 19 2014 26 12 38 2013 12 1 13 2012 28 5 33 2011 23 9 32 2010 26 5 31 2009 34 4 39 2008 47 4 51 2007 39 4 43 2006 32 32 2005 55 2 57 2004 57 5 62 Sums 412 62 474 M/F 6.65
Last Updated on 30 Jul 2016
Contributors: Juraj Gasparovic (18), Klaas Loonstra (45)


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See:
Description
| Interface Summary | |
|---|---|
| AttributeSet | |
| DynamicChangeable | Defines an interface for resource dynamic XML content. |
| DynamicContentHandler | The DynamicContentHandler interface is a tagging interface that
identifies an object as a source of dynamic content. |
| Identifier | This interface defines an equality relation between two objects. |
| KeyIdentifier | This interface defines an equality relation between two keys. |
| Class Summary | |
|---|---|
| ArrayIdentifier | This class implements an equality relation between two arrays. |
| ArrayValueType | |
| ContentWriter | |
| DynamicChangeable.AlwaysChanged | |
| DynamicChangeableFactory | |
| DynamicContent | |
| DynamicContentAssembler | The DynamicContentAssembler implements an assembler for
assembling dynamic Content objects. |
| DynamicContentKey | This class provides an implementation of a key used to uniquely identify XML documents. |
| DynamicContentReader | A DynamicContentReader implement a SAX 2 XMLReader interface for feeding
start/end elements back to an application requesting an XML document. |
| FieldDescriptor | |
| KeyIdentifierImpl | This class provides an implementation of a KeyIdentifier . |
| RecordMetaData | |
| RecordMetaDataFactory | |
| ScalarValueType | |
| ValueType |
Provides interfaces and classes for obtaining XML content through a SAX 2 ContentHandler.
|
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Whether you realize it or not, you set certain expectations when you enter a movie theater. These could be developed from seeing a preview, hearing rumors or gossip, seeing a poster, or maybe just from hearing the name. I am quite guilty of this as well, and it sometimes unfairly influences my opinion on a movie. This usually means that a movie doesn't live up to what I thought I was going to see. But every so often, something wonderful happens. I have certain expectations set forth, and when I see the movie, I am completely and pleasantly surprised. The latter is the case with Ever After, a pleasantly fun and wonderful retelling of the tale of Cinderella (Grimm, not Disney, so no pumpkins, sorry).
The story, along with Romeo and Juliet, is probably the most well known love story of our time. Hence, there is no need for me to outline the plot, because it follows the tale pretty much to the letter. Nor will I really spend much time analyzing points and aspects of this movie, because plain and simply, the surprising charm of this movie, is that it is fun. This is the most fun I've had in a theater in quite a long time. This differed from how much I laughed at There's Something About Mary, for the simple of fact that I didn't feel bad about laughing here.  The story has been told, and retold, but this is the most energetic retelling yet (Disney's was more romantic, but this one has more humor and fun). The characters are real, believable. Angelica Huston makes you want to boo her every appearance on screen (then again she, like Michael Douglas, can do that in her sleep, but she does it oh so well), Drew makes you want to cheer, or sigh, as you do for a heroine. The prince (played with confident charming effectiveness by newcomer Dougray Scott) makes you cheer, and makes the women envious, and even swoon at times. All of the characters work in the context of the tale. The king and queen are powerful, yet real, and even the character who becomes the cupid of the two fate-crossed lovers (won't ruin the surprise) turns in a wonderfully watchable, comic performance.
You have noticed me mentioning comedy a lot, because therein was where the surprise lay for me. I didn't expect to laugh as much as I did. It isn't just slapstick, physical humor either (although that exists) but some rather deep, intelligent smart humor that I didn't expect. The humor came from all angles, not even in excess, but rather to keep the movie from getting to serious about itself. Most of all, this movie never forgot it was a fairy tale. Whenever the storyline seemed to be getting mushy, intense, or emotional, here came the humor, or the one-liner, to bring the smile back.
This movie will have the reverse effect of Saving Private Ryan, from this aspect. When you leave Private Ryan, you feel, as one friend of mine put it, like you're leaving a funeral. It was depressing, about a depressing and serious topic. But when Ever After is over, your face will hurt from smiling, and laughing so much. It makes you (to be cliché) "feel-good". Sure, there are flaws, Drew's accent slips, historically, they may make some mistakes, but you know what?. Who cares, it is fun, you can take kids, you can go as adults and not be ashamed, and you can leave with a smile, and energy in your heart. My recommendation, give this movie a chance, as soon as possible, you won't regret it.
See more of my Reel Ramblings at http://www.angelfire.com/ks/nearside/comingatt.html
-----== Posted via Deja News, The Leader in Internet Discussion ==----- http://www.dejanews.com/rg_mkgrp.xp Create Your Own Free Member Forum
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rec.arts.movies.reviews newsgroup (de.rec.film.kritiken for German reviews).
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Related links: index of all rec.arts.movies.reviews reviews


Free Domain Registration
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We also reserve the right to decline a domain registration without any explanation.
For technical reasons, domain registration on our behalf is only available for annual plans.
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{% extends "oauth2_provider/base.html" %} {% load i18n %} {% block content %}
Do you, {{request.user.first_name|title }} {{request.user.last_name|title }}, approve {{ application.name }} for {{settings.PROTECTED_RESOURCE_TITLE}} from the {{ settings.DATA_SOURCE_TITLE }}?
You have the right to share your health information, but there may be risks. Be sure to review the Patient Data Access from {{ settings.DATA_SOURCE_TITLE }}'s Privacy Policy and Terms and Conditions. You can revoke (cancel) {{ application.name }}'s access to your data at any time by logging in to this site and selecting "Revoke" from the Application Access Tokens menu item. You can also cancel your Share My Health account, which will stop {{ application.name }}'s access to your health information held by {{ settings.DATA_SOURCE_TITLE }}. When you allow Patient Data Access from {{ settings.DATA_SOURCE_TITLE }} you and any social service providers you approve receive {{settings.PROTECTED_RESOURCE_TITLE}}. While you may revoke access at any time, it is not possible to take back information already shared.
Please note that {{ settings.DATA_SOURCE_TITLE }} has only some of your personal health information. {{ settings.DATA_SOURCE_TITLE }} personal health information is not your official or complete medical record.
{{ error.description }}


Instead of defining all of your route-level logic in a single routes.php
file, you may wish to organize this behavior using Controller classes. Controllers can group related route logic into a class, as well as take advantage of more advanced framework features such as automatic dependency injection.
Controllers are typically stored in the app/controllers
directory, and this directory is registered in the classmap
option of your composer.json
file by default. However, controllers can technically live in any directory or any sub-directory. Route declarations are not dependent on the location of the controller class file on disk. So, as long as Composer knows how to autoload the controller class, it may be placed anywhere you wish.
Here is an example of a basic controller class:
class UserController extends BaseController {
/**
* Show the profile for the given user.
*/
public function showProfile($id)
{
$user = User::find($id);
return View::make('user.profile', array('user' => $user));
}
}
All controllers should extend the BaseController
class. The BaseController
is also stored in the app/controllers
directory, and may be used as a place to put shared controller logic. The BaseController
extends the framework's Controller
class. Now, we can route to this controller action like so:
Route::get('user/{id}', 'UserController@showProfile');
If you choose to nest or organize your controller using PHP namespaces, simply use the fully qualified class name when defining the route:
Route::get('foo', 'Namespace\FooController@method');
Note: Since we're using Composer to auto-load our PHP classes, controllers may live anywhere on the file system, as long as composer knows how to load them. The controller directory does not enforce any folder structure for your application. Routing to controllers is entirely de-coupled from the file system.
You may also specify names on controller routes:
Route::get('foo', array('uses' => 'FooController@method',
'as' => 'name'));
To generate a URL to a controller action, you may use the URL::action
method or the action
helper method:
$url = URL::action('FooController@method');
$url = action('FooController@method');
You may access the name of the controller action being run using the currentRouteAction
method:
$action = Route::currentRouteAction();

Filters may be specified on controller routes similar to "regular" routes:
Route::get('profile', array('before' => 'auth',
'uses' => 'UserController@showProfile'));
However, you may also specify filters from within your controller:
class UserController extends BaseController {
/**
* Instantiate a new UserController instance.
*/
public function __construct()
{
$this->beforeFilter('auth', array('except' => 'getLogin'));
$this->beforeFilter('csrf', array('on' => 'post'));
$this->afterFilter('log', array('only' =>
array('fooAction', 'barAction')));
}
}
You may also specify controller filters inline using a Closure:
class UserController extends BaseController {
/**
* Instantiate a new UserController instance.
*/
public function __construct()
{
$this->beforeFilter(function()
{
//
});
}
}
If you would like to use another method on the controller as a filter, you may use @
syntax to define the filter:
class UserController extends BaseController {
/**
* Instantiate a new UserController instance.
*/
public function __construct()
{
$this->beforeFilter('@filterRequests');
}
/**
* Filter the incoming requests.
*/
public function filterRequests($route, $request)
{
//
}
}

Laravel allows you to easily define a single route to handle every action in a controller using simple, REST naming conventions. First, define the route using the Route::controller
method:
Route::controller('users', 'UserController');
The controller
method accepts two arguments. The first is the base URI the controller handles, while the second is the class name of the controller. Next, just add methods to your controller, prefixed with the HTTP verb they respond to:
class UserController extends BaseController {
public function getIndex()
{
//
}
public function postProfile()
{
//
}
public function anyLogin()
{
//
}
}
The index
methods will respond to the root URI handled by the controller, which, in this case, is users
.
If your controller action contains multiple words, you may access the action using "dash" syntax in the URI. For example, the following controller action on our UserController
would respond to the users/admin-profile
URI:
public function getAdminProfile() {}

Resource controllers make it easier to build RESTful controllers around resources. For example, you may wish to create a controller that manages "photos" stored by your application. Using the controller:make
command via the Artisan CLI and the Route::resource
method, we can quickly create such a controller.
To create the controller via the command line, execute the following command:
php artisan controller:make PhotoController
Now we can register a resourceful route to the controller:
Route::resource('photo', 'PhotoController');
This single route declaration creates multiple routes to handle a variety of RESTful actions on the photo resource. Likewise, the generated controller will already have stubbed methods for each of these actions with notes informing you which URIs and verbs they handle.
Verb | Path | Action | Route Name ----------|-----------------------------|--------------|--------------------- GET | /resource | index | resource.index GET | /resource/create | create | resource.create POST | /resource | store | resource.store GET | /resource/{resource} | show | resource.show GET | /resource/{resource}/edit | edit | resource.edit PUT/PATCH | /resource/{resource} | update | resource.update DELETE | /resource/{resource} | destroy | resource.destroy
Sometimes you may only need to handle a subset of the resource actions:
php artisan controller:make PhotoController --only=index,show
php artisan controller:make PhotoController --except=index
And, you may also specify a subset of actions to handle on the route:
Route::resource('photo', 'PhotoController',
array('only' => array('index', 'show')));
Route::resource('photo', 'PhotoController',
array('except' => array('create', 'store', 'update', 'destroy')));
By default, all resource controller actions have a route name; however, you can override these names by passing a names
array with your options:
Route::resource('photo', 'PhotoController',
array('names' => array('create' => 'photo.build')));

A catch-all method may be defined which will be called when no other matching method is found on a given controller. The method should be named missingMethod
, and receives the method and parameter array for the request:
public function missingMethod($parameters = array())
{
//
}


vignettes/top_20_bottom_10_report.Rmd
top_20_bottom_10_report.Rmd
The “Mean of Top 20/ bottom 10” analysis is performed on multiplexed fluorescent IHC images. The analysis helps to evaluate whether the staining quality is likely to produce good unmixing of the markers in the image. The analysis computes the mean expression of selected markers in the 20 highest-expressing cells and the 10% lowest-expressing cells. The resulting Excel workbook has tabs showing
Generally, the best unmixing results are obtained when the expression levels of all fluors (excluding DAPI) are within the range of 10-30 normalized counts. Most importantly, the ratio between neighboring fluors should fall between 0.3-3 for multispectral IM3 images or 0.1-10 for MOTiF images. When one fluor is 3x/10x (IM3/MOTiF) brighter than its neighboring fluor, unmixing error and crosstalk are more likely to occur.
The signal-to-background value helps to assess background levels in relation to real, positive signal. When higher background is present, resulting in a lower signal-to-background ratio, cell scoring based on thresholding will be less reliable and will likely result in more false positives. Phenotyping may also be more challenging. The app is will flag signal-to-background values of 30 or less within the Opal 780 channel as this fluor tends to have lower intensities with higher background levels.
The input to this report is a merged cell seg data file from inForm containing data about the samples to measure, and a configuration file naming the markers of interest.
The configuration file is a plain text file (.txt
). It contains the names of the columns to measure, one name per line, without the units information. For example, a configuration file might have these contents:
Nucleus DAPI Mean
Membrane CD8 (Opal 480) Mean
Membrane PDL1 (Opal 520) Mean
Nucleus Ki67 (Opal 570) Mean
Cytoplasm CD68 (Opal 620) Mean
Membrane CK (Opal 690) Mean
Membrane PD1 (Opal 780) Mean
The order of entries in the configuration file determines which markers will be compared as adjacent markers in the report.
Click the “Browse” button in the “Select Merge Data” section of the GUI. Use the file selection dialog to select the file containing your merge data.
If the merge file contains tissue category data, select the tissue categories to analyze.
You can report by slide or by field. Make the appropriate selection in the “Summarize by” drop-down.
This table gives some general guidelines for interpreting the results.
| Worksheet Tab | Guidelines |
|---|---|
| Top 20 data |
Optimal signal intensity for unmixing is typically between 10-30 for all fluors except Opal 780, which should be at least between 1-10. Reliable data can still be obtained when signals are as low as a few counts or as high as 50 or more counts, but risks are higher for crosstalk issues. |
| Bottom 10%ile data |
Optimal background for unmixing is less than 10. Values greater than 10 are indicative of background staining. Higher DAPI intensities are OK since all cells will be expressing DAPI, meaning this value is a measure of the lowest real signals and not truly background. |
| Ratio top to bottom |
The signal-to-background value helps to assess background levels in relation to real, positive signal. Optimal ratios for top to bottom are values greater than 20. Values much greater than 20 are common. “#NUM” indicates zero background. When higher background is present, resulting in a lower signal-to-background ratio, cell scoring based on thresholding will be less reliable and will likely result in more false positives. For the Opal 780 channel, the report will flag signal-to-background values of 30 or less as this fluor tends to have lower intensities with higher background levels. For DAPI, low numbers can indicate that bottom expressors are high, which is OK as this is not truly a signal-to-background assessment but is a ratio of high to low expressing cells. |
| Ratio adjacent fluors |
Optimal ratios for adjacent fluors are between 0.3-3 or 0.1-10 for IM3 and MOTiF images, respectively. Values below or above these ranges indicate the potential of a fluor bleeding into a neighboring fluor. When one fluor is greater than 3x (IM3) or 10x (MOTiF) brighter than its neighboring fluor, unmixing error and crosstalk are more likely to occur. |


Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections in the United States. Cervical infection with certain types of HPV is a major risk factor for cervical cancer in women. The “high-risk” types of HPV (e.g., HPV 16, 18) are associated with cervical cancer as well as other anogenital cancers, and the “low-risk” types of HPV (e.g., HPV 6, 11) with genital warts. No national surveillance system exists to measure the full burden of HPV infection, and no reliable national population estimate of HPV exists. NHANES offers a unique opportunity to assess the prevalence of HPV infection in the general population.
Reducing the prevalence of HPV infection is a Developmental Healthy People 2010 objective: “Reducing the number of new HPV cases can help minimize the overall number of cases of high risk subtypes associated with cervical cancer in females...” Detection and typing of HPV DNA in vaginal swabs will allow evaluation of trends in prevalence of type-specific HPV infection by age, sexual behavior, and race/ethnicity. Three HPV vaccines (Gardasil, Gardasil 9, and Cervarix) are licensed and recommended for use in females. Two vaccines are licensed and recommended for use in males (Gardasil and Gardasil 9). In mid-2006, the Advisory Committee on Immunizations (ACIP) recommended routine vaccination of females aged 11 or 12 years and for those 13-26 years not previously vaccinated. In December 2011, ACIP recommended routine vaccination of males aged 11 or 12 years and for those aged 13 through 21 years not previously vaccinated. As a vaccine becomes more widely used, the national prevalence of HPV infection will be critical for evaluating vaccination strategies in the United States.
Examined female participants aged 14-59 years were eligible. This public data file includes data for examined participants aged 18 to 59 years. Please see Analytic Notes about the release of data for adolescents aged 14-17 years.
DNA extraction was performed with a modified protocol and the commercial QIAamp kit (Qiagen, 2003). Presence of high-risk HPV in the extracted participant DNA is determined with the Cobas Human Papillomavirus (HPV) test. This qualitative in-vitro diagnostics test uses oligonucleotide probes labeled with four different fluorescent dyes. The primers target a DNA region of approximately 200 nucleotides within the polymorphic L1 region of the HPV genome to detect 14 high-risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68) in a single analysis. The test reported concurrently the presence of one or more of these types at clinically relevant infection levels, however the test was modified from the FDA approved format (sample type and extraction) and results cannot be used clinically. Refer to the Laboratory Method Files section for a detailed description of the laboratory methods used.
HPV Vaginal Swab Cobas High Risk Laboratory Procedure Manual (November 2018)
Vaginal swab samples were processed, stored, and shipped to the Chronic Viral Diseases Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA for analysis.
Detailed instructions on specimen collection and processing are discussed in the NHANES Laboratory Procedures Manual (LPM). Swabs were stored at room temperature until they were shipped to the National Center for Emerging and Zoonotic Infectious Diseases for testing.
Detailed QA/QC instructions are discussed in the NHANES LPM.
Mobile Examination Centers (MECs)
Laboratory team performance is monitored using several techniques. NCHS and contract consultants use a structured competency assessment evaluation during visits to evaluate both the quality of the laboratory work and the quality-control procedures. Each laboratory staff member is observed for equipment operation, specimen collection and preparation; testing procedures and constructive feedback are given to each staff member. Formal retraining sessions are conducted annually to ensure that required skill levels were maintained.
Analytical Laboratories
NHANES uses several methods to monitor the quality of the analyses performed by the contract laboratories. In the MEC, these methods include performing blind split samples collected on “dry run” sessions. In addition, contract laboratories randomly perform repeat testing on 2% of all specimens.
Progress reports containing any problems encountered during shipping or receipt of specimens, summary statistics for each control pool, QC graphs, instrument calibration, reagents, and any special considerations are submitted to NCHS quarterly. The reports are reviewed for trends or shifts in the data. The laboratories are required to explain any identified areas of concern.
The data were reviewed. Incomplete data or improbable
values were sent to the performing laboratory for confirmation.
Refer to the 2015-2016 Laboratory Data Overview for general information on NHANES laboratory data.
Sample Weights
MEC exam sample weights should be used for analyses.
Demographic and Other Related Variables
The analysis of NHANES laboratory data must be conducted using the appropriate survey design and demographic variables. The NHANES 2015-2016 Demographics File contains demographic data, health indicators, and other related information collected during household interviews as well as the sample design variables. The recommended procedure for variance estimation requires use of stratum and PSU variables (SDMVSTRA and SDMVPSU, respectively) in the demographic data file.
This laboratory data file can be linked to the other NHANES data files using the unique survey participant identifier (i.e., SEQN).
The Questionnaire data files contain socio-economic data, health indicators, and other related information collected during household interviews. Certain sensitive data on participants under 18 years of age (e.g., HPV typing results, sexual behavior variables) are not included in the public use files. These data may be requested as described in the NHANES guidelines.
The public release data file includes HPV vaginal swab data for participants aged 18-59. HPV vaginal swab data for youth aged 14-17 years are available through the NCHS Research Data Center (RDC).
Roche Cobas HPV DNA Test
The Roche Cobas HPV test is qualitative and only determines the presence or absence of high-risk HPV. If any analyte (HPV 16, HPV 18, or Other High-risk HPV) is indicated as positive (POS) in the Cobas result file, the result for the sample ID will be recorded as positive. If all of the HPV analytes are negative (NEG) in the Cobas result file the result for the sample ID will be recorded as negative. If any of the analytes are indicated as invalid in the Cobas result file, the DNA from that sample will be re-tested one time to obtain valid results. If the repeated result is still invalid, the final result will be recorded as inadequate (Cobas Operator’s Manual, 2009).
Detection Limits
If data is qualitative, the use of lower limits of detection (LLODs) is not applicable.
Please refer to the NHANES Analytic Guidelines and the on-line NHANES Tutorial for further details on the use of sample weights and other analytic issues.
| Code or Value | Value Description | Count | Cumulative | Skip to Item |
|---|---|---|---|---|
| 1 | Positive | 359 | 359 | |
| 2 | Negative | 1475 | 1834 | |
| 3 | Inadequate | 38 | 1872 | |
| . | Missing | 192 | 2064 |


A popover service to keep state of opened popover. Allowing user to hide certain
or all popovers
popoverList
Type: Array
The popover that's currently being shown
registered
Type: Array
Object storing all the registered popover DOM elements
last
Type: Function
Get data of the last popover
register
Type: Function
Register a popover with an id and an element
unregister
Type: Function
Remove id and element from registered list of popover
add
Type: Function
Add a new popover to opened list
pop
Type: Function
Get and remove the last popover from list
show
Type: Function
Show and position a registered popover
getById
Type: Function
Get opened popover object by id
resize
Type: Function
Update size and position of an opened popover
hide
Type: Function
Hide a certain popover. If no selector is provided, the
last opened popover is hidden
hideAll
Type: Function
Hide all popovers


Using Sublime SFTP to Edit Remote Files
Command line-based text editors like vim and Emacs have a steep learning curve and even simple tasks like navigating around in the interface isn’t always straightforward for beginners. In this tutorial, we’ll show you how to edit files on a remote server like Compute Canada in an intuitive and easy manner using Sublime Text 3 and SFTP.
Set Up
-
First, download Sublime Text 3.
-
Then install the Package Control plugin using the instructions on the page.
-
Once Package Control is installed, restart Sublime Text then press
Ctrl+Shift+P
to open the Command Palette. Type Install and selectPackage Control: Install Package
. Type inSFTP
and press Enter to install the SFTP package.
Select Your Folder
First, you’ll have to select and open a folder that you want to sync with the remote server. You can create a new folder if you’re starting from scratch, then go to File > Open Folder
in Sublime Text to open that folder. Right click on the folder that you’ve just selected and you should see a SFTP/FTP
and Map to Remote
option in the context menu.
Clicking on Map to Remote
creates a sftp-config.json
file to save your settings which looks something like this:
{
// The tab key will cycle through the settings when first created
// Visit http://wbond.net/sublime_packages/sftp/settings for help
// sftp, ftp or ftps
"type": "sftp",
"save_before_upload": true,
"upload_on_save": true,
"sync_down_on_open": false,
"sync_skip_deletes": false,
"sync_same_age": true,
"confirm_downloads": false,
"confirm_sync": true,
"confirm_overwrite_newer": false,
"host": "<IP_ADDRESS>",
"user": "ubuntu",
"port": "22",
"remote_path": "/home/ubuntu/wlr/",
"ignore_regexes": [
"\\.sublime-(project|workspace)", "sftp-config(-alt\\d?)?\\.json",
"sftp-settings\\.json", "/venv/", "\\.svn/", "\\.hg/", "\\.git/",
"\\.bzr", "_darcs", "CVS", "\\.DS_Store", "Thumbs\\.db", "desktop\\.ini"
],
"connect_timeout": 30
}
Settings Configuration
There are several important parameters that you need to fill in for SFTP to work:
- host
- user
- port
- remote_path
If you’re following our Compute Canada Cloud tutorial, host
is the floating IP adress that you get from the Compute Canada config page. user
would be ubuntu and port
is 22. Otherwise, please use the settings for your server.
remote_path
refers to the path on the remote server where the files will be synced. The path must exist on the server for this to work. For example, if you want to sync /home/mycomputer/dais/
on your own computer to /home/ubuntu/dais
on the remote server, you will need to first create the dais
folder on the remote server. This is easy, just SSH into the server (as explained in the Compute Canada Cloud setup tutorial) and use mkdir dais
to create a directory called dais
.
I usually leave the other settings on their default value, except upload_on_save
, which I set to true
. Setting it to true will ask SFTP to automatically upload the file to the server everytime you save it on your computer.
Running Your Program
My workflow is simple. I write my code in Sublime Text 3 and use SFTP to automatically sync it to the Compute Canada server whenever I save the file. I would then SSH into the server and then run my program from the terminal. For example, if I have a python file called main.py
, I would edit and sync the file then SSH into the server and run python main.py
.
Syncing Remote Files To Your Computer
If you have a program that dumps some output on the server, you can (very conveniently) grab the files to your computer using the Sync Remote to Local
command or Download Folder
command. For example, if your results are dumped into a folder called output
, simply right click on that folder in Sublime Text then select Download Folder
to download the entire folder, or Sync Remote to Local
to only grab files that you don’t have on your computer.
Final Notes
To save yourself some time and mouse clicks, check out the SFTP page and learn the shortcuts for uploading/downloading files: https://wbond.net/sublime_packages/sftp/usage


An attempt at writing a DesignScript parser and interpreter that runs in the browser. You can use it to parse, generate, and run DesignScript code. Because there is no spec for the DesignScript language, it probably has semantic issues. :)
Most of the project is written in TypeScript.
See src/AST.ts
for a complete list.


{% extends "layout.html" %} {% block main %}
An internal server error occurred, please try again later :(
If the problem persists contact the technical support


The module Foreign.Marshal.Array provides operations for marshalling Haskell lists into monolithic arrays and vice versa. Most functions come in two flavours: one for arrays terminated by a special termination element and one where an explicit length parameter is used to determine the extent of an array. The typical example for the former case are C’s NUL terminated strings. However, please note that C strings should usually be marshalled using the functions provided by Foreign.C.String as the Unicode encoding has to be taken into account. All functions specifically operating on arrays that are terminated by a special termination element have a name ending on 0—e.g., mallocArray allocates space for an array of the given size, whereas mallocArray0 allocates space for one more element to ensure that there is room for the terminator.
| mallocArray :: Storable a => Int -> IO (Ptr a) |
| mallocArray0 :: Storable a => Int -> IO (Ptr a) |
| allocaArray :: Storable a => Int -> (Ptr a -> IO b) -> IO b |
| allocaArray0 :: Storable a => Int -> (Ptr a -> IO b) -> IO b |
| reallocArray :: Storable a => Ptr a -> Int -> IO (Ptr a) |
| reallocArray0 :: Storable a => Ptr a -> Int -> IO (Ptr a) |
| peekArray :: Storable a => Int -> Ptr a -> IO [a] |
| peekArray0 :: (Storable a, Eq a) => a -> Ptr a -> IO [a] |
| pokeArray :: Storable a => Ptr a -> [a] -> IO () |
| pokeArray0 :: Storable a => a -> Ptr a -> [a] -> IO () |
| newArray :: Storable a => [a] -> IO (Ptr a) |
| newArray0 :: Storable a => a -> [a] -> IO (Ptr a) |
| withArray :: Storable a => [a] -> (Ptr a -> IO b) -> IO b |
| withArray0 :: Storable a => a -> [a] -> (Ptr a -> IO b) -> IO b |
| withArrayLen :: Storable a => [a] -> (Int -> Ptr a -> IO b) -> IO b |
| withArrayLen0 :: Storable a => a |
| -> [a] -> (Int -> Ptr a -> IO b) -> IO b |
(argument order: destination, source)
| copyArray :: Storable a => Ptr a -> Ptr a -> Int -> IO () |
| moveArray :: Storable a => Ptr a -> Ptr a -> Int -> IO () |
| lengthArray0 :: (Storable a, Eq a) => a -> Ptr a -> IO Int |
| advancePtr :: Storable a => Ptr a -> Int -> Ptr a |


Who we are
We are the type of people you would like to do business with. We are the type of people you would like to do business with. We are the type of people you would like to do business with. We are the type of people you would like to do business with. We are the type of people you would like to do business with.
Testimonial from a client about us.


Beyond 'click-next-to-continue'
Mobile learning and apps
Learners expect experiences they can touch and tools which are accessible from anywhere. We use HTML5 to build responsive content which learners can navigate like the apps and websites they love. One experience on any device.
Animations and video
An eye-popping animation is a great way to open a course. It’s also a standalone asset to help you promote it. You can have a message from your CEO to open the training, video testimonials from some of your employees, interviews with your subject matter experts or dramatised scenarios using actors. You can film in a studio, on location or in virtual worlds (using green or blue screen).
Interaction and scenarios
What makes great classroom training great? Often it’s the instructor involving the audience, encouraging interaction – and making eye contact. We believe online training is no different. Our elearning solutions are fully interactive, using activities, quizzes and highly developed scenarios.
Gamification
Game mechanics in learning motivate achievement by satisfying psychological needs. We build in performance indicators that measure how well learners doing as they answer questions, complete tasks or make decisions. This flags up weaker areas early on and spurs them on when they’re on a roll.


Damaged: {{bike.damaged?"Yes":"No"}}
Available: {{bike.available?"Yes":"No"}}
Type: {{bike.bikeType.name}}
Capacity: {{bike.bikeType.capacity}}
| Bike ID | Brand | Damaged | Maintenance | BikeType | Actions |
|---|---|---|---|---|---|
| {{bike.id}} | {{bike.brand}} | {{bike.damaged}} | {{bike.mantenimiento}} | {{bike.bikeType.name}} | Set as Available |


On this page, Home Info System will be born. This system allows the centralisation of home related information.