| exposure DMARD or NSAID vs TNF At database=Medicare | 5.372 | 0.664 | 43.484 |
| exposure No exposure vs TNF At database=Medicare | 4.685 | 0.720 | 30.473 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27624 | 42 | 27582 | 99.85 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 1440.242 | 1398.480 |
| AIC | 1440.242 | 1416.480 |
| SBC | 1440.242 | 1432.119 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 41.7613 | 9 | <.0001 |
| Score (Model-Based) | 36.0313 | 9 | <.0001 |
| Score (Sandwich) | 27.1484 | 9 | 0.0013 |
| Wald (Model-Based) | 24.9031 | 9 | 0.0031 |
| Wald (Sandwich) | 4401.8782 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.7323 | 0.2551 |
| database | 2 | 620.6650 | <.0001 |
| exposure*database | 4 | 222.2397 | <.0001 |
| SEX | 1 | 0.8657 | 0.3521 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 1.78356 | 1.08837 | 2.067 | 2.6855 | 0.1013 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.63021 | 1.02931 | 2.203 | 2.5084 | 0.1132 | exposure No exposure | ||||
| database | MPCD | 1 | -13.13292 | 1.00675 | 0.002 | 170.1703 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | 1.68349 | 1.20651 | 2.686 | 1.9470 | 0.1629 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 12.61046 | 1.48165 | 0.003 | 72.4385 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -2.79990 | 1.50219 | 1.795 | 3.4740 | 0.0623 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 12.21085 | 1.43117 | 0.003 | 72.7966 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -3.05843 | 1.47765 | 1.788 | 4.2840 | 0.0385 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | -0.50209 | 0.53961 | 2.245 | 0.8657 | 0.3521 | 0.605 | 0.210 | 1.743 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1783380 | 243837.7 | 13043280 |
| exposure No exposure vs TNF At database=MPCD | 1025881 | 141048.5 | 7461497 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.362 | 0.046 | 2.859 |
| exposure No exposure vs TNF At database=Marketscan | 0.240 | 0.036 | 1.586 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 5.951 | 0.705 | 50.235 |
| exposure No exposure vs TNF At database=Medicare | 5.105 | 0.679 | 38.383 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27624 | 42 | 27582 | 99.85 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 1440.242 | 1392.123 |
| AIC | 1440.242 | 1410.123 |
| SBC | 1440.242 | 1425.762 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 48.1183 | 9 | <.0001 |
| Score (Model-Based) | 47.2488 | 9 | <.0001 |
| Score (Sandwich) | 32.8667 | 9 | 0.0001 |
| Wald (Model-Based) | 33.9796 | 9 | <.0001 |
| Wald (Sandwich) | 4467.7915 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 7.8161 | 0.0201 |
| database | 2 | 611.3739 | <.0001 |
| exposure*database | 4 | 202.0215 | <.0001 |
| indHospInf | 1 | 3.0550 | 0.0805 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 1.44654 | 1.21664 | 2.287 | 1.4136 | 0.2345 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.75188 | 0.78763 | 1.643 | 4.9472 | 0.0261 | exposure No exposure | ||||
| database | MPCD | 1 | -12.19797 | 0.80387 | 0.002 | 230.2510 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | 1.85191 | 1.04204 | 2.288 | 3.1584 | 0.0755 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 12.20571 | 1.58416 | 0.004 | 59.3648 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -2.53263 | 1.57777 | 1.880 | 2.5766 | 0.1085 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 11.36654 | 1.27930 | 0.003 | 78.9427 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -3.12339 | 1.29600 | 1.561 | 5.8082 | 0.0160 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | 1.58148 | 0.90482 | 2.126 | 3.0550 | 0.0805 | 4.862 | 0.825 | 28.643 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 849368.8 | 115028.3 | 6271740 |
| exposure No exposure vs TNF At database=MPCD | 498034.5 | 68326.01 | 3630219 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.338 | 0.042 | 2.728 |
| exposure No exposure vs TNF At database=Marketscan | 0.254 | 0.038 | 1.713 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 4.248 | 0.391 | 46.114 |
| exposure No exposure vs TNF At database=Medicare | 5.765 | 1.231 | 26.994 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27624 | 42 | 27582 | 99.85 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 1440.242 | 1376.804 |
| AIC | 1440.242 | 1404.804 |
| SBC | 1440.242 | 1429.132 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 63.4374 | 14 | <.0001 |
| Score (Model-Based) | 69.3311 | 14 | <.0001 |
| Score (Sandwich) | 35.6998 | 14 | 0.0012 |
| Wald (Model-Based) | 53.6140 | 14 | <.0001 |
| Wald (Sandwich) | 5551.7498 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 8.5388 | 0.0140 |
| database | 2 | 658.6453 | <.0001 |
| exposure*database | 4 | 219.4094 | <.0001 |
| meanPredEqDoseCat | 4 | 1538.8580 | <.0001 |
| SEX | 1 | 0.9299 | 0.3349 |
| indHospInf | 1 | 3.8749 | 0.0490 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 1.48910 | 1.32070 | 2.460 | 1.2713 | 0.2595 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.83491 | 0.82990 | 1.734 | 4.8885 | 0.0270 | exposure No exposure | ||||
| database | MPCD | 1 | -12.64883 | 0.76505 | 0.002 | 273.3503 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | 1.88299 | 1.04314 | 2.291 | 3.2585 | 0.0711 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 12.67705 | 1.61188 | 0.003 | 61.8546 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -2.53663 | 1.65725 | 1.970 | 2.3428 | 0.1259 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 11.73284 | 1.29491 | 0.003 | 82.0974 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -3.22974 | 1.37490 | 1.656 | 5.5182 | 0.0188 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -13.26084 | 0.48859 | 0.000 | 736.6263 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.52920 | 0.53288 | 1.558 | 0.9862 | 0.3207 | 0.589 | 0.207 | 1.674 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 1.24687 | 0.95724 | 2.205 | 1.6967 | 0.1927 | 3.479 | 0.533 | 22.715 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -0.07658 | 0.67858 | 1.201 | 0.0127 | 0.9101 | 0.926 | 0.245 | 3.502 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | -0.50868 | 0.52750 | 2.189 | 0.9299 | 0.3349 | 0.601 | 0.214 | 1.691 | Administrative Sex F | |
| indHospInf | 1 | 1.59151 | 0.80850 | 1.854 | 3.8749 | 0.0490 | 4.911 | 1.007 | 23.954 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1419980 | 195310.4 | 10323789 |
| exposure No exposure vs TNF At database=MPCD | 780542.8 | 107299.2 | 5678020 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.351 | 0.045 | 2.718 |
| exposure No exposure vs TNF At database=Marketscan | 0.248 | 0.035 | 1.746 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 4.433 | 0.333 | 59.006 |
| exposure No exposure vs TNF At database=Medicare | 6.265 | 1.232 | 31.864 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 27624 | 42 | 27582 | 99.85 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 264.341 | 250.972 |
| AIC | 264.341 | 274.972 |
| SBC | 264.341 | 295.825 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 13.3684 | 12 | 0.3428 |
| Score (Model-Based) | 11.0770 | 12 | 0.5223 |
| Score (Sandwich) | 36.5974 | 12 | 0.0003 |
| Wald (Model-Based) | 6.2388 | 12 | 0.9036 |
| Wald (Sandwich) | 6114.9808 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 2.7288 | 0.2555 |
| database | 2 | 758.0590 | <.0001 |
| exposure*database | 4 | 259.8374 | <.0001 |
| meanPredEqDoseCat | 4 | 1470.9726 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | 1.57459 | 1.08447 | 0.569 | 2.1082 | 0.1465 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | 1.59715 | 0.96688 | 0.582 | 2.7287 | 0.0986 | exposure No exposure | ||||
| database | MPCD | 1 | -14.16870 | 0.96643 | 0.001 | 214.9398 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | 1.64991 | 1.16945 | 1.001 | 1.9905 | 0.1583 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 13.73567 | 1.45308 | 0.001 | 89.3552 | <.0001 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | -2.68828 | 1.46016 | 0.634 | 3.3896 | 0.0656 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 13.14150 | 1.40062 | 0.001 | 88.0334 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | -3.06764 | 1.43891 | 0.657 | 4.5451 | 0.0330 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -14.99577 | 0.62815 | 0.000 | 569.9198 | <.0001 | 0.000 | 0.000 | 0.000 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.98923 | 0.86439 | 1.063 | 1.3097 | 0.2524 | 0.372 | 0.068 | 2.024 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.94474 | 1.13913 | 0.984 | 0.6878 | 0.4069 | 2.572 | 0.276 | 23.984 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | -1.73300 | 0.85549 | 0.315 | 4.1037 | 0.0428 | 0.177 | 0.033 | 0.945 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 4458241 | 587319.7 | 33841719 |
| exposure No exposure vs TNF At database=MPCD | 2517197 | 344245.6 | 18406274 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.328 | 0.039 | 2.761 |
| exposure No exposure vs TNF At database=Marketscan | 0.230 | 0.034 | 1.560 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 4.829 | 0.576 | 40.452 |
| exposure No exposure vs TNF At database=Medicare | 4.939 | 0.742 | 32.858 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26623 | 1221 | 25402 | 95.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 21941.484 | 21599.237 |
| AIC | 21941.484 | 21615.237 |
| SBC | 21941.484 | 21656.097 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 342.2471 | 8 | <.0001 |
| Score (Model-Based) | 306.5746 | 8 | <.0001 |
| Score (Sandwich) | 344.8569 | 8 | <.0001 |
| Wald (Model-Based) | 266.6626 | 8 | <.0001 |
| Wald (Sandwich) | 260.2989 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.1902 | 0.5515 |
| database | 2 | 62.9712 | <.0001 |
| exposure*database | 4 | 7.4897 | 0.1122 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.09834 | 0.16998 | 1.002 | 0.3347 | 0.5629 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.00355 | 0.15772 | 1.000 | 0.0005 | 0.9820 | exposure No exposure | ||||
| database | MPCD | 1 | -1.32080 | 0.31792 | 1.004 | 17.2605 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.65082 | 0.21220 | 1.000 | 60.5213 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.20765 | 0.46656 | 1.002 | 0.1981 | 0.6563 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.39908 | 0.28068 | 0.999 | 2.0216 | 0.1551 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.73041 | 0.34900 | 1.004 | 4.3802 | 0.0364 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.45778 | 0.24450 | 0.998 | 3.5057 | 0.0612 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.116 | 0.475 | 2.622 |
| exposure No exposure vs TNF At database=MPCD | 2.069 | 1.124 | 3.806 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 1.351 | 0.871 | 2.094 |
| exposure No exposure vs TNF At database=Marketscan | 1.575 | 1.091 | 2.274 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.906 | 0.650 | 1.265 |
| exposure No exposure vs TNF At database=Medicare | 0.996 | 0.731 | 1.357 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26623 | 1221 | 25402 | 95.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 47851.421 | 46916.692 |
| AIC | 47851.421 | 46932.692 |
| SBC | 47851.421 | 46973.551 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 934.7295 | 8 | <.0001 |
| Score (Model-Based) | 848.7484 | 8 | <.0001 |
| Score (Sandwich) | 226.3061 | 8 | <.0001 |
| Wald (Model-Based) | 708.9222 | 8 | <.0001 |
| Wald (Sandwich) | 208.9118 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 0.7752 | 0.6787 |
| database | 2 | 39.3822 | <.0001 |
| exposure*database | 4 | 9.1078 | 0.0585 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.16689 | 0.23054 | 2.949 | 0.5241 | 0.4691 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.06534 | 0.20366 | 4.135 | 0.1029 | 0.7484 | exposure No exposure | ||||
| database | MPCD | 1 | -1.89298 | 0.39807 | 2.560 | 22.6138 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.55686 | 0.28056 | 3.519 | 30.7920 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.82984 | 0.55295 | 1.689 | 2.2523 | 0.1334 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.14640 | 0.33265 | 1.772 | 0.1937 | 0.6599 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.22595 | 0.42366 | 2.044 | 8.3737 | 0.0038 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.31319 | 0.30353 | 2.217 | 1.0646 | 0.3022 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.941 | 0.706 | 5.334 |
| exposure No exposure vs TNF At database=MPCD | 3.192 | 1.544 | 6.597 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.980 | 0.588 | 1.631 |
| exposure No exposure vs TNF At database=Marketscan | 1.281 | 0.818 | 2.006 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.846 | 0.539 | 1.330 |
| exposure No exposure vs TNF At database=Medicare | 0.937 | 0.628 | 1.396 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26623 | 1221 | 25402 | 95.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 47851.421 | 46862.857 |
| AIC | 47851.421 | 46886.857 |
| SBC | 47851.421 | 46948.146 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 988.5647 | 12 | <.0001 |
| Score (Model-Based) | 920.7633 | 12 | <.0001 |
| Score (Sandwich) | 232.0862 | 12 | <.0001 |
| Wald (Model-Based) | 774.9958 | 12 | <.0001 |
| Wald (Sandwich) | 220.1457 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.0676 | 0.5864 |
| database | 2 | 39.1984 | <.0001 |
| exposure*database | 4 | 9.6727 | 0.0463 |
| meanPredEqDoseCat | 4 | 5.8765 | 0.2086 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.18376 | 0.22819 | 2.919 | 0.6485 | 0.4207 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.06197 | 0.20435 | 4.141 | 0.0920 | 0.7617 | exposure No exposure | ||||
| database | MPCD | 1 | -1.88052 | 0.39723 | 2.555 | 22.4114 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.55622 | 0.28064 | 3.518 | 30.7509 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.83105 | 0.55206 | 1.686 | 2.2661 | 0.1322 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.15336 | 0.33185 | 1.767 | 0.2136 | 0.6440 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.25432 | 0.42184 | 2.034 | 8.8414 | 0.0029 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.33108 | 0.30239 | 2.208 | 1.1988 | 0.2736 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.38719 | 0.64277 | 1.511 | 0.3628 | 0.5469 | 0.679 | 0.193 | 2.393 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.16304 | 0.21622 | 4.410 | 0.5686 | 0.4508 | 1.177 | 0.770 | 1.798 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.76504 | 0.34101 | 3.278 | 5.0331 | 0.0249 | 2.149 | 1.102 | 4.193 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.18438 | 0.29106 | 3.298 | 0.4013 | 0.5264 | 1.202 | 0.680 | 2.127 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.910 | 0.695 | 5.254 |
| exposure No exposure vs TNF At database=MPCD | 3.295 | 1.591 | 6.825 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.970 | 0.582 | 1.617 |
| exposure No exposure vs TNF At database=Marketscan | 1.309 | 0.836 | 2.049 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.832 | 0.532 | 1.301 |
| exposure No exposure vs TNF At database=Medicare | 0.940 | 0.630 | 1.403 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26623 | 1221 | 25402 | 95.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 47851.421 | 46838.786 |
| AIC | 47851.421 | 46856.786 |
| SBC | 47851.421 | 46902.753 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 1012.6352 | 9 | <.0001 |
| Score (Model-Based) | 923.4581 | 9 | <.0001 |
| Score (Sandwich) | 230.9099 | 9 | <.0001 |
| Wald (Model-Based) | 783.2167 | 9 | <.0001 |
| Wald (Sandwich) | 207.6791 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.0236 | 0.5994 |
| database | 2 | 39.3453 | <.0001 |
| exposure*database | 4 | 9.8178 | 0.0436 |
| SEX | 1 | 4.3600 | 0.0368 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.23480 | 0.24194 | 3.082 | 0.9419 | 0.3318 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.14126 | 0.21000 | 4.194 | 0.4525 | 0.5012 | exposure No exposure | ||||
| database | MPCD | 1 | -1.88393 | 0.39713 | 2.554 | 22.5043 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.56397 | 0.28140 | 3.530 | 30.8898 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.86449 | 0.55387 | 1.692 | 2.4362 | 0.1186 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.18656 | 0.33577 | 1.788 | 0.3087 | 0.5785 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.27036 | 0.42613 | 2.055 | 8.8875 | 0.0029 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.38727 | 0.30908 | 2.253 | 1.5700 | 0.2102 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | 0.37857 | 0.18130 | 4.159 | 4.3600 | 0.0368 | 1.460 | 1.023 | 2.083 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.877 | 0.684 | 5.151 |
| exposure No exposure vs TNF At database=MPCD | 3.093 | 1.501 | 6.373 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.953 | 0.570 | 1.592 |
| exposure No exposure vs TNF At database=Marketscan | 1.279 | 0.817 | 2.003 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.791 | 0.492 | 1.270 |
| exposure No exposure vs TNF At database=Medicare | 0.868 | 0.575 | 1.310 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26623 | 1221 | 25402 | 95.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 47851.421 | 46914.236 |
| AIC | 47851.421 | 46932.236 |
| SBC | 47851.421 | 46978.203 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 937.1852 | 9 | <.0001 |
| Score (Model-Based) | 852.3194 | 9 | <.0001 |
| Score (Sandwich) | 226.6215 | 9 | <.0001 |
| Wald (Model-Based) | 711.9712 | 9 | <.0001 |
| Wald (Sandwich) | 209.8462 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.0550 | 0.5901 |
| database | 2 | 37.9750 | <.0001 |
| exposure*database | 4 | 8.6014 | 0.0719 |
| indHospInf | 1 | 0.2248 | 0.6354 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.18072 | 0.22519 | 2.860 | 0.6441 | 0.4222 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.05653 | 0.20906 | 4.213 | 0.0731 | 0.7869 | exposure No exposure | ||||
| database | MPCD | 1 | -1.88370 | 0.40117 | 2.578 | 22.0481 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.55001 | 0.28358 | 3.551 | 29.8760 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.84348 | 0.55113 | 1.683 | 2.3423 | 0.1259 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.15829 | 0.32993 | 1.756 | 0.2302 | 0.6314 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.21727 | 0.42631 | 2.056 | 8.1531 | 0.0043 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.30680 | 0.30603 | 2.234 | 1.0050 | 0.3161 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | 0.17488 | 0.36887 | 3.386 | 0.2248 | 0.6354 | 1.191 | 0.578 | 2.454 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.940 | 0.706 | 5.333 |
| exposure No exposure vs TNF At database=MPCD | 3.192 | 1.545 | 6.598 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.978 | 0.587 | 1.628 |
| exposure No exposure vs TNF At database=Marketscan | 1.284 | 0.820 | 2.011 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.835 | 0.537 | 1.298 |
| exposure No exposure vs TNF At database=Medicare | 0.945 | 0.627 | 1.424 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26623 | 1221 | 25402 | 95.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 47851.421 | 46791.360 |
| AIC | 47851.421 | 46819.360 |
| SBC | 47851.421 | 46890.864 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 1060.0613 | 14 | <.0001 |
| Score (Model-Based) | 991.4155 | 14 | <.0001 |
| Score (Sandwich) | 240.0059 | 14 | <.0001 |
| Wald (Model-Based) | 844.8928 | 14 | <.0001 |
| Wald (Sandwich) | 221.3579 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 1.4286 | 0.4895 |
| database | 2 | 37.8294 | <.0001 |
| exposure*database | 4 | 9.7036 | 0.0457 |
| meanPredEqDoseCat | 4 | 5.7809 | 0.2161 |
| SEX | 1 | 3.9380 | 0.0472 |
| indHospInf | 1 | 0.0685 | 0.7936 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.25049 | 0.23367 | 2.959 | 1.1491 | 0.2837 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.12787 | 0.21682 | 4.288 | 0.3478 | 0.5554 | exposure No exposure | ||||
| database | MPCD | 1 | -1.86563 | 0.39981 | 2.569 | 21.7741 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.55605 | 0.28439 | 3.560 | 29.9369 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.87213 | 0.55131 | 1.683 | 2.5025 | 0.1137 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.19586 | 0.33252 | 1.769 | 0.3469 | 0.5559 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.28168 | 0.42688 | 2.056 | 9.0148 | 0.0027 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.39215 | 0.31041 | 2.262 | 1.5960 | 0.2065 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.48541 | 0.67425 | 1.584 | 0.5183 | 0.4716 | 0.615 | 0.164 | 2.307 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.11850 | 0.21879 | 4.437 | 0.2934 | 0.5881 | 1.126 | 0.733 | 1.729 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.73456 | 0.32914 | 3.160 | 4.9807 | 0.0256 | 2.085 | 1.094 | 3.974 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.12178 | 0.29517 | 3.318 | 0.1702 | 0.6799 | 1.130 | 0.633 | 2.014 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | 0.36172 | 0.18228 | 4.154 | 3.9380 | 0.0472 | 1.436 | 1.004 | 2.052 | Administrative Sex F | |
| indHospInf | 1 | 0.09814 | 0.37510 | 3.421 | 0.0685 | 0.7936 | 1.103 | 0.529 | 2.301 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.862 | 0.678 | 5.114 |
| exposure No exposure vs TNF At database=MPCD | 3.170 | 1.533 | 6.557 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.947 | 0.566 | 1.583 |
| exposure No exposure vs TNF At database=Marketscan | 1.302 | 0.832 | 2.040 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.778 | 0.492 | 1.231 |
| exposure No exposure vs TNF At database=Medicare | 0.880 | 0.575 | 1.346 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26623 | 1221 | 25402 | 95.41 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 5182.646 | 4994.596 |
| AIC | 5182.646 | 5018.596 |
| SBC | 5182.646 | 5079.885 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 188.0494 | 12 | <.0001 |
| Score (Model-Based) | 232.8478 | 12 | <.0001 |
| Score (Sandwich) | 280.6306 | 12 | <.0001 |
| Wald (Model-Based) | 193.3678 | 12 | <.0001 |
| Wald (Sandwich) | 229.4965 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 0.6559 | 0.7204 |
| database | 2 | 40.1175 | <.0001 |
| exposure*database | 4 | 9.2039 | 0.0562 |
| meanPredEqDoseCat | 4 | 8.8919 | 0.0639 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.15032 | 0.23152 | 0.674 | 0.4215 | 0.5162 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.04821 | 0.20783 | 0.944 | 0.0538 | 0.8166 | exposure No exposure | ||||
| database | MPCD | 1 | -1.88560 | 0.39797 | 1.697 | 22.4491 | <.0001 | database MPCD | ||||
| database | Marketscan | 1 | -1.57431 | 0.27929 | 1.949 | 31.7744 | <.0001 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.83351 | 0.55461 | 0.743 | 2.2586 | 0.1329 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.16933 | 0.33035 | 0.693 | 0.2627 | 0.6083 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.24578 | 0.42548 | 0.878 | 8.5727 | 0.0034 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.32715 | 0.30235 | 0.907 | 1.1708 | 0.2792 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -1.16401 | 0.74107 | 0.428 | 2.4671 | 0.1162 | 0.312 | 0.073 | 1.334 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.36887 | 0.23982 | 1.855 | 2.3659 | 0.1240 | 1.446 | 0.904 | 2.314 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.82308 | 0.39928 | 1.292 | 4.2495 | 0.0393 | 2.278 | 1.041 | 4.981 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.13134 | 0.37095 | 1.412 | 0.1254 | 0.7233 | 1.140 | 0.551 | 2.359 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.980 | 0.711 | 5.515 |
| exposure No exposure vs TNF At database=MPCD | 3.312 | 1.601 | 6.853 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 1.019 | 0.618 | 1.682 |
| exposure No exposure vs TNF At database=Marketscan | 1.322 | 0.845 | 2.067 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.860 | 0.547 | 1.355 |
| exposure No exposure vs TNF At database=Medicare | 0.953 | 0.634 | 1.432 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26369 | 641 | 25728 | 97.57 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 12080.547 | 12026.849 |
| AIC | 12080.547 | 12042.849 |
| SBC | 12080.547 | 12078.553 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 53.6979 | 8 | <.0001 |
| Score (Model-Based) | 56.8511 | 8 | <.0001 |
| Score (Sandwich) | 49.9867 | 8 | <.0001 |
| Wald (Model-Based) | 54.5815 | 8 | <.0001 |
| Wald (Sandwich) | 54.8154 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 23.1983 | <.0001 |
| database | 2 | 4.6990 | 0.0954 |
| exposure*database | 4 | 6.6880 | 0.1533 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.12125 | 0.23302 | 1.009 | 23.1545 | <.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.70922 | 0.20379 | 1.007 | 12.1112 | 0.0005 | exposure No exposure | ||||
| database | MPCD | 1 | -0.65529 | 0.30835 | 1.003 | 4.5163 | 0.0336 | database MPCD | ||||
| database | Marketscan | 1 | -0.17734 | 0.20949 | 1.006 | 0.7167 | 0.3972 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.68741 | 0.48668 | 1.000 | 1.9950 | 0.1578 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.56178 | 0.28442 | 1.005 | 3.9015 | 0.0482 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 0.80177 | 0.35791 | 1.000 | 5.0183 | 0.0251 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.36483 | 0.24263 | 1.001 | 2.2610 | 0.1327 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.648 | 0.281 | 1.497 |
| exposure No exposure vs TNF At database=MPCD | 1.097 | 0.614 | 1.959 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.572 | 0.414 | 0.789 |
| exposure No exposure vs TNF At database=Marketscan | 0.709 | 0.545 | 0.922 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.326 | 0.206 | 0.515 |
| exposure No exposure vs TNF At database=Medicare | 0.492 | 0.330 | 0.734 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26369 | 641 | 25728 | 97.57 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 34248.264 | 34048.163 |
| AIC | 34248.264 | 34064.163 |
| SBC | 34248.264 | 34099.868 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 200.1009 | 8 | <.0001 |
| Score (Model-Based) | 184.0546 | 8 | <.0001 |
| Score (Sandwich) | 40.1646 | 8 | <.0001 |
| Wald (Model-Based) | 173.1965 | 8 | <.0001 |
| Wald (Sandwich) | 47.4598 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 15.6393 | 0.0004 |
| database | 2 | 10.9866 | 0.0041 |
| exposure*database | 4 | 9.0923 | 0.0588 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.03388 | 0.27538 | 2.030 | 14.0954 | 0.0002 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.52521 | 0.23083 | 2.879 | 5.1772 | 0.0229 | exposure No exposure | ||||
| database | MPCD | 1 | -1.12360 | 0.39424 | 2.733 | 8.1228 | 0.0044 | database MPCD | ||||
| database | Marketscan | 1 | -0.02140 | 0.25968 | 4.231 | 0.0068 | 0.9343 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.13698 | 0.54650 | 1.503 | 4.3285 | 0.0375 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.41703 | 0.32420 | 1.747 | 1.6547 | 0.1983 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.21534 | 0.43018 | 1.934 | 7.9818 | 0.0047 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.20794 | 0.27839 | 2.201 | 0.5579 | 0.4551 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.109 | 0.434 | 2.832 |
| exposure No exposure vs TNF At database=MPCD | 1.994 | 0.978 | 4.066 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.540 | 0.374 | 0.779 |
| exposure No exposure vs TNF At database=Marketscan | 0.728 | 0.539 | 0.983 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.356 | 0.207 | 0.610 |
| exposure No exposure vs TNF At database=Medicare | 0.591 | 0.376 | 0.930 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26369 | 641 | 25728 | 97.57 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 34248.264 | 34039.791 |
| AIC | 34248.264 | 34063.791 |
| SBC | 34248.264 | 34117.348 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 208.4729 | 12 | <.0001 |
| Score (Model-Based) | 192.1248 | 12 | <.0001 |
| Score (Sandwich) | 42.8494 | 12 | <.0001 |
| Wald (Model-Based) | 181.2733 | 12 | <.0001 |
| Wald (Sandwich) | 50.6189 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 15.7564 | 0.0004 |
| database | 2 | 10.8365 | 0.0044 |
| exposure*database | 4 | 9.0929 | 0.0588 |
| meanPredEqDoseCat | 4 | 1.5008 | 0.8265 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.03480 | 0.27472 | 2.025 | 14.1887 | 0.0002 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.52592 | 0.23226 | 2.895 | 5.1271 | 0.0236 | exposure No exposure | ||||
| database | MPCD | 1 | -1.12362 | 0.39826 | 2.759 | 7.9598 | 0.0048 | database MPCD | ||||
| database | Marketscan | 1 | -0.01425 | 0.26118 | 4.248 | 0.0030 | 0.9565 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.14779 | 0.54855 | 1.508 | 4.3781 | 0.0364 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.41988 | 0.32391 | 1.745 | 1.6803 | 0.1949 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.21954 | 0.43306 | 1.945 | 7.9303 | 0.0049 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.20585 | 0.27837 | 2.201 | 0.5468 | 0.4596 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.71140 | 0.78349 | 1.456 | 0.8245 | 0.3639 | 0.491 | 0.106 | 2.280 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.08011 | 0.21321 | 3.510 | 0.1412 | 0.7071 | 0.923 | 0.608 | 1.402 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.14720 | 0.38534 | 2.340 | 0.1459 | 0.7025 | 1.159 | 0.544 | 2.466 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.18024 | 0.35151 | 3.368 | 0.2629 | 0.6081 | 1.198 | 0.601 | 2.385 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.120 | 0.435 | 2.879 |
| exposure No exposure vs TNF At database=MPCD | 2.001 | 0.970 | 4.128 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.541 | 0.375 | 0.780 |
| exposure No exposure vs TNF At database=Marketscan | 0.726 | 0.534 | 0.986 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.355 | 0.207 | 0.609 |
| exposure No exposure vs TNF At database=Medicare | 0.591 | 0.375 | 0.932 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26369 | 641 | 25728 | 97.57 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 34248.264 | 34043.727 |
| AIC | 34248.264 | 34061.727 |
| SBC | 34248.264 | 34101.895 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 204.5371 | 9 | <.0001 |
| Score (Model-Based) | 188.5180 | 9 | <.0001 |
| Score (Sandwich) | 40.4170 | 9 | <.0001 |
| Wald (Model-Based) | 177.6507 | 9 | <.0001 |
| Wald (Sandwich) | 47.6951 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 16.3617 | 0.0003 |
| database | 2 | 10.8982 | 0.0043 |
| exposure*database | 4 | 9.1562 | 0.0573 |
| SEX | 1 | 0.3139 | 0.5753 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.05200 | 0.27214 | 2.002 | 14.9433 | 0.0001 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.54421 | 0.23009 | 2.851 | 5.5942 | 0.0180 | exposure No exposure | ||||
| database | MPCD | 1 | -1.11967 | 0.39510 | 2.739 | 8.0308 | 0.0046 | database MPCD | ||||
| database | Marketscan | 1 | -0.02129 | 0.25962 | 4.230 | 0.0067 | 0.9346 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.14754 | 0.54559 | 1.500 | 4.4238 | 0.0354 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.42806 | 0.32180 | 1.733 | 1.7694 | 0.1835 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.22713 | 0.42923 | 1.929 | 8.1734 | 0.0043 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.22726 | 0.27560 | 2.173 | 0.6800 | 0.4096 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | 0.10565 | 0.18858 | 3.749 | 0.3139 | 0.5753 | 1.111 | 0.768 | 1.608 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.100 | 0.431 | 2.810 |
| exposure No exposure vs TNF At database=MPCD | 1.980 | 0.969 | 4.042 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.536 | 0.371 | 0.774 |
| exposure No exposure vs TNF At database=Marketscan | 0.728 | 0.540 | 0.983 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.349 | 0.205 | 0.595 |
| exposure No exposure vs TNF At database=Medicare | 0.580 | 0.370 | 0.911 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26369 | 641 | 25728 | 97.57 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 34248.264 | 34043.649 |
| AIC | 34248.264 | 34061.649 |
| SBC | 34248.264 | 34101.816 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 204.6158 | 9 | <.0001 |
| Score (Model-Based) | 188.1401 | 9 | <.0001 |
| Score (Sandwich) | 40.2606 | 9 | <.0001 |
| Wald (Model-Based) | 177.3539 | 9 | <.0001 |
| Wald (Sandwich) | 47.3018 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 14.0871 | 0.0009 |
| database | 2 | 11.0939 | 0.0039 |
| exposure*database | 4 | 9.0221 | 0.0605 |
| indHospInf | 1 | 0.3581 | 0.5496 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.00543 | 0.27419 | 2.013 | 13.4464 | 0.0002 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.54137 | 0.23507 | 2.922 | 5.3040 | 0.0213 | exposure No exposure | ||||
| database | MPCD | 1 | -1.14027 | 0.39684 | 2.748 | 8.2563 | 0.0041 | database MPCD | ||||
| database | Marketscan | 1 | -0.03432 | 0.26237 | 4.258 | 0.0171 | 0.8959 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.10897 | 0.54560 | 1.499 | 4.1314 | 0.0421 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.39216 | 0.32293 | 1.737 | 1.4747 | 0.2246 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.23130 | 0.43240 | 1.943 | 8.1088 | 0.0044 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.22023 | 0.28078 | 2.218 | 0.6152 | 0.4328 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | -0.33301 | 0.55647 | 3.375 | 0.3581 | 0.5496 | 0.717 | 0.241 | 2.133 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.109 | 0.434 | 2.833 |
| exposure No exposure vs TNF At database=MPCD | 1.994 | 0.978 | 4.065 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.542 | 0.375 | 0.782 |
| exposure No exposure vs TNF At database=Marketscan | 0.725 | 0.537 | 0.979 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.366 | 0.214 | 0.626 |
| exposure No exposure vs TNF At database=Medicare | 0.582 | 0.367 | 0.923 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26369 | 641 | 25728 | 97.57 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 34248.264 | 34029.741 |
| AIC | 34248.264 | 34057.741 |
| SBC | 34248.264 | 34120.223 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 218.5238 | 14 | <.0001 |
| Score (Model-Based) | 201.6123 | 14 | <.0001 |
| Score (Sandwich) | 43.8914 | 14 | <.0001 |
| Wald (Model-Based) | 190.9206 | 14 | <.0001 |
| Wald (Sandwich) | 51.2812 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 14.7964 | 0.0006 |
| database | 2 | 10.8754 | 0.0043 |
| exposure*database | 4 | 9.0608 | 0.0596 |
| meanPredEqDoseCat | 4 | 1.6052 | 0.8079 |
| SEX | 1 | 0.3821 | 0.5365 |
| indHospInf | 1 | 0.4574 | 0.4989 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.02351 | 0.27112 | 1.988 | 14.2519 | 0.0002 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.56474 | 0.23576 | 2.907 | 5.7382 | 0.0166 | exposure No exposure | ||||
| database | MPCD | 1 | -1.13875 | 0.40149 | 2.777 | 8.0445 | 0.0046 | database MPCD | ||||
| database | Marketscan | 1 | -0.02870 | 0.26381 | 4.273 | 0.0118 | 0.9134 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.13006 | 0.54804 | 1.506 | 4.2518 | 0.0392 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.40565 | 0.32026 | 1.722 | 1.6044 | 0.2053 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.25059 | 0.43490 | 1.951 | 8.2689 | 0.0040 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.24048 | 0.27850 | 2.194 | 0.7456 | 0.3879 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.73444 | 0.79040 | 1.468 | 0.8634 | 0.3528 | 0.480 | 0.102 | 2.259 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.08591 | 0.20828 | 3.418 | 0.1701 | 0.6800 | 0.918 | 0.610 | 1.380 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.14997 | 0.38789 | 2.355 | 0.1495 | 0.6990 | 1.162 | 0.543 | 2.485 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.18309 | 0.33737 | 3.217 | 0.2945 | 0.5873 | 1.201 | 0.620 | 2.326 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | 0.11317 | 0.18307 | 3.619 | 0.3821 | 0.5365 | 1.120 | 0.782 | 1.603 | Administrative Sex F | |
| indHospInf | 1 | -0.36579 | 0.54088 | 3.270 | 0.4574 | 0.4989 | 0.694 | 0.240 | 2.002 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.112 | 0.432 | 2.861 |
| exposure No exposure vs TNF At database=MPCD | 1.985 | 0.961 | 4.103 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.539 | 0.373 | 0.779 |
| exposure No exposure vs TNF At database=Marketscan | 0.723 | 0.532 | 0.983 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.359 | 0.211 | 0.611 |
| exposure No exposure vs TNF At database=Medicare | 0.569 | 0.358 | 0.902 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26369 | 641 | 25728 | 97.57 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 6553.294 | 6500.435 |
| AIC | 6553.294 | 6524.435 |
| SBC | 6553.294 | 6577.991 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 52.8590 | 12 | <.0001 |
| Score (Model-Based) | 46.5775 | 12 | <.0001 |
| Score (Sandwich) | 40.1700 | 12 | <.0001 |
| Wald (Model-Based) | 43.1900 | 12 | <.0001 |
| Wald (Sandwich) | 51.4505 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 13.8704 | 0.0010 |
| database | 2 | 10.8277 | 0.0045 |
| exposure*database | 4 | 9.1217 | 0.0581 |
| meanPredEqDoseCat | 4 | 2.3259 | 0.6761 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.99954 | 0.27459 | 0.448 | 13.2505 | 0.0003 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -0.57123 | 0.23538 | 0.604 | 5.8896 | 0.0152 | exposure No exposure | ||||
| database | MPCD | 1 | -1.13368 | 0.40240 | 1.758 | 7.9371 | 0.0048 | database MPCD | ||||
| database | Marketscan | 1 | -0.00818 | 0.26075 | 1.927 | 0.0010 | 0.9750 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.17102 | 0.55106 | 0.584 | 4.5158 | 0.0336 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.43068 | 0.32375 | 0.489 | 1.7696 | 0.1834 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.24169 | 0.43872 | 0.709 | 8.0102 | 0.0047 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 0.22619 | 0.28170 | 0.644 | 0.6447 | 0.4220 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.70645 | 0.76284 | 0.662 | 0.8576 | 0.3544 | 0.493 | 0.111 | 2.201 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | -0.10290 | 0.18079 | 1.434 | 0.3239 | 0.5693 | 0.902 | 0.633 | 1.286 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.36608 | 0.47841 | 1.431 | 0.5855 | 0.4442 | 1.442 | 0.565 | 3.683 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.16166 | 0.29209 | 1.285 | 0.3063 | 0.5799 | 1.175 | 0.663 | 2.084 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.187 | 0.459 | 3.071 |
| exposure No exposure vs TNF At database=MPCD | 1.955 | 0.944 | 4.051 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.566 | 0.393 | 0.817 |
| exposure No exposure vs TNF At database=Marketscan | 0.708 | 0.520 | 0.965 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.368 | 0.215 | 0.630 |
| exposure No exposure vs TNF At database=Medicare | 0.565 | 0.356 | 0.896 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26922 | 484 | 26438 | 98.20 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 9166.291 | 8998.473 |
| AIC | 9166.291 | 9014.473 |
| SBC | 9166.291 | 9047.930 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 167.8184 | 8 | <.0001 |
| Score (Model-Based) | 167.7800 | 8 | <.0001 |
| Score (Sandwich) | 141.4612 | 8 | <.0001 |
| Wald (Model-Based) | 147.8283 | 8 | <.0001 |
| Wald (Sandwich) | 143.2637 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 14.9333 | 0.0006 |
| database | 2 | 1.0759 | 0.5839 |
| exposure*database | 4 | 17.6892 | 0.0014 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.97515 | 0.30173 | 0.992 | 10.4451 | 0.0012 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.05453 | 0.27788 | 1.012 | 14.4014 | 0.0001 | exposure No exposure | ||||
| database | MPCD | 1 | 0.11461 | 0.33698 | 0.993 | 0.1157 | 0.7338 | database MPCD | ||||
| database | Marketscan | 1 | 0.25197 | 0.26591 | 0.991 | 0.8979 | 0.3433 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 0.70269 | 0.49143 | 0.994 | 2.0446 | 0.1528 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.62546 | 0.34873 | 0.996 | 3.2168 | 0.0729 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 1.16612 | 0.39030 | 1.001 | 8.9269 | 0.0028 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.21649 | 0.30472 | 1.003 | 15.9375 | <.0001 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 0.762 | 0.355 | 1.633 |
| exposure No exposure vs TNF At database=MPCD | 1.118 | 0.648 | 1.930 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.705 | 0.499 | 0.995 |
| exposure No exposure vs TNF At database=Marketscan | 1.176 | 0.905 | 1.527 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.377 | 0.209 | 0.681 |
| exposure No exposure vs TNF At database=Medicare | 0.348 | 0.202 | 0.601 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26922 | 484 | 26438 | 98.20 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 25396.172 | 25146.423 |
| AIC | 25396.172 | 25162.423 |
| SBC | 25396.172 | 25195.880 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 249.7484 | 8 | <.0001 |
| Score (Model-Based) | 219.0164 | 8 | <.0001 |
| Score (Sandwich) | 120.4981 | 8 | <.0001 |
| Wald (Model-Based) | 196.5840 | 8 | <.0001 |
| Wald (Sandwich) | 142.8794 | 8 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 8.6689 | 0.0131 |
| database | 2 | 4.9694 | 0.0834 |
| exposure*database | 4 | 19.1943 | 0.0007 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.01941 | 0.42749 | 2.427 | 5.6864 | 0.0171 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.21139 | 0.41407 | 3.478 | 8.5588 | 0.0034 | exposure No exposure | ||||
| database | MPCD | 1 | -0.69077 | 0.52189 | 3.590 | 1.7519 | 0.1856 | database MPCD | ||||
| database | Marketscan | 1 | 0.06540 | 0.44200 | 6.118 | 0.0219 | 0.8824 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.51244 | 0.63839 | 1.799 | 5.6129 | 0.0178 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.85352 | 0.50495 | 2.275 | 2.8571 | 0.0910 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 2.06653 | 0.54270 | 2.398 | 14.5001 | 0.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.43556 | 0.44583 | 2.955 | 10.3681 | 0.0013 | exposure No exposure * database Marketscan |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.637 | 0.672 | 3.992 |
| exposure No exposure vs TNF At database=MPCD | 2.352 | 1.156 | 4.784 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.847 | 0.575 | 1.247 |
| exposure No exposure vs TNF At database=Marketscan | 1.251 | 0.928 | 1.687 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.361 | 0.156 | 0.834 |
| exposure No exposure vs TNF At database=Medicare | 0.298 | 0.132 | 0.670 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26922 | 484 | 26438 | 98.20 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 25396.172 | 25064.345 |
| AIC | 25396.172 | 25088.345 |
| SBC | 25396.172 | 25138.530 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 331.8262 | 12 | <.0001 |
| Score (Model-Based) | 306.8697 | 12 | <.0001 |
| Score (Sandwich) | 122.1151 | 12 | <.0001 |
| Wald (Model-Based) | 281.6957 | 12 | <.0001 |
| Wald (Sandwich) | 146.9144 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 8.8636 | 0.0119 |
| database | 2 | 4.8384 | 0.0890 |
| exposure*database | 4 | 18.4915 | 0.0010 |
| meanPredEqDoseCat | 4 | 3.9396 | 0.4142 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.03941 | 0.42801 | 2.430 | 5.8973 | 0.0152 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.19325 | 0.40271 | 3.380 | 8.7799 | 0.0030 | exposure No exposure | ||||
| database | MPCD | 1 | -0.69884 | 0.52525 | 3.612 | 1.7702 | 0.1834 | database MPCD | ||||
| database | Marketscan | 1 | 0.04274 | 0.45393 | 6.272 | 0.0089 | 0.9250 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.50033 | 0.62747 | 1.768 | 5.7172 | 0.0168 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.84652 | 0.49657 | 2.237 | 2.9061 | 0.0882 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 2.14922 | 0.56975 | 2.514 | 14.2296 | 0.0002 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.47110 | 0.45716 | 3.029 | 10.3549 | 0.0013 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -1.01282 | 1.04574 | 1.314 | 0.9380 | 0.3328 | 0.363 | 0.047 | 2.820 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.55768 | 0.37593 | 6.093 | 2.2007 | 0.1380 | 1.747 | 0.836 | 3.649 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.41011 | 0.61524 | 3.250 | 0.4443 | 0.5050 | 1.507 | 0.451 | 5.033 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.22778 | 0.31720 | 2.375 | 0.5157 | 0.4727 | 1.256 | 0.674 | 2.338 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.586 | 0.653 | 3.851 |
| exposure No exposure vs TNF At database=MPCD | 2.601 | 1.258 | 5.376 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.825 | 0.563 | 1.208 |
| exposure No exposure vs TNF At database=Marketscan | 1.320 | 0.964 | 1.809 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.354 | 0.153 | 0.818 |
| exposure No exposure vs TNF At database=Medicare | 0.303 | 0.138 | 0.668 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 | |
| SEX | F | 1 | |
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26922 | 484 | 26438 | 98.20 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 25396.172 | 25066.434 |
| AIC | 25396.172 | 25084.434 |
| SBC | 25396.172 | 25122.073 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 329.7371 | 9 | <.0001 |
| Score (Model-Based) | 301.7047 | 9 | <.0001 |
| Score (Sandwich) | 122.9063 | 9 | <.0001 |
| Wald (Model-Based) | 275.8250 | 9 | <.0001 |
| Wald (Sandwich) | 151.2231 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 8.3140 | 0.0157 |
| database | 2 | 5.1229 | 0.0772 |
| exposure*database | 4 | 18.8409 | 0.0008 |
| SEX | 1 | 3.8445 | 0.0499 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.92669 | 0.40283 | 2.283 | 5.2921 | 0.0214 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.11581 | 0.38896 | 3.257 | 8.2292 | 0.0041 | exposure No exposure | ||||
| database | MPCD | 1 | -0.71826 | 0.53146 | 3.655 | 1.8265 | 0.1765 | database MPCD | ||||
| database | Marketscan | 1 | 0.06057 | 0.44321 | 6.132 | 0.0187 | 0.8913 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.46524 | 0.62940 | 1.774 | 5.4196 | 0.0199 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.79946 | 0.49114 | 2.211 | 2.6496 | 0.1036 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 2.01497 | 0.53345 | 2.356 | 14.2674 | 0.0002 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.34234 | 0.42193 | 2.791 | 10.1215 | 0.0015 | exposure No exposure * database Marketscan | |||
| SEX | F | 1 | -0.51259 | 0.26143 | 4.524 | 3.8445 | 0.0499 | 0.599 | 0.359 | 1.000 | Administrative Sex F |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.714 | 0.696 | 4.217 |
| exposure No exposure vs TNF At database=MPCD | 2.458 | 1.195 | 5.052 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.881 | 0.594 | 1.306 |
| exposure No exposure vs TNF At database=Marketscan | 1.254 | 0.930 | 1.691 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.396 | 0.180 | 0.872 |
| exposure No exposure vs TNF At database=Medicare | 0.328 | 0.153 | 0.702 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||
|---|---|---|---|
| Class | Value | Design Variables | |
| exposure | DMARD or NSAID | 1 | 0 |
| No exposure | 0 | 1 | |
| TNF | 0 | 0 | |
| database | MPCD | 1 | 0 |
| Marketscan | 0 | 1 | |
| Medicare | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26922 | 484 | 26438 | 98.20 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 25396.172 | 25085.979 |
| AIC | 25396.172 | 25103.979 |
| SBC | 25396.172 | 25141.618 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 310.1925 | 9 | <.0001 |
| Score (Model-Based) | 255.4136 | 9 | <.0001 |
| Score (Sandwich) | 137.7478 | 9 | <.0001 |
| Wald (Model-Based) | 216.3367 | 9 | <.0001 |
| Wald (Sandwich) | 149.4781 | 9 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 10.3914 | 0.0055 |
| database | 2 | 5.1833 | 0.0749 |
| exposure*database | 4 | 22.1359 | 0.0002 |
| indHospInf | 1 | 15.0798 | 0.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.93336 | 0.42471 | 2.411 | 4.8297 | 0.0280 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.27473 | 0.41492 | 3.485 | 9.4387 | 0.0021 | exposure No exposure | ||||
| database | MPCD | 1 | -0.75572 | 0.52241 | 3.593 | 2.0927 | 0.1480 | database MPCD | ||||
| database | Marketscan | 1 | 0.01298 | 0.44241 | 6.119 | 0.0009 | 0.9766 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.42639 | 0.63621 | 1.793 | 5.0266 | 0.0250 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.77624 | 0.50212 | 2.261 | 2.3898 | 0.1221 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 2.12897 | 0.54323 | 2.400 | 15.3594 | <.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.48599 | 0.44634 | 2.959 | 11.0842 | 0.0009 | exposure No exposure * database Marketscan | |||
| indHospInf | 1 | -2.54520 | 0.65543 | 1.211 | 15.0798 | 0.0001 | 0.078 | 0.022 | 0.283 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.637 | 0.672 | 3.992 |
| exposure No exposure vs TNF At database=MPCD | 2.350 | 1.155 | 4.780 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.855 | 0.581 | 1.258 |
| exposure No exposure vs TNF At database=Marketscan | 1.235 | 0.916 | 1.665 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.393 | 0.171 | 0.904 |
| exposure No exposure vs TNF At database=Medicare | 0.280 | 0.124 | 0.630 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptw |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 | |
| SEX | F | 1 | |||
| M | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26922 | 484 | 26438 | 98.20 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 25396.172 | 24904.529 |
| AIC | 25396.172 | 24932.529 |
| SBC | 25396.172 | 24991.078 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 491.6423 | 14 | <.0001 |
| Score (Model-Based) | 442.3939 | 14 | <.0001 |
| Score (Sandwich) | 141.2187 | 14 | <.0001 |
| Wald (Model-Based) | 398.7400 | 14 | <.0001 |
| Wald (Sandwich) | 162.3472 | 14 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 10.2559 | 0.0059 |
| database | 2 | 5.1814 | 0.0750 |
| exposure*database | 4 | 21.3363 | 0.0003 |
| meanPredEqDoseCat | 4 | 4.9642 | 0.2910 |
| SEX | 1 | 4.1089 | 0.0427 |
| indHospInf | 1 | 15.3513 | <.0001 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -0.87145 | 0.40469 | 2.294 | 4.6371 | 0.0313 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.16425 | 0.37890 | 3.173 | 9.4414 | 0.0021 | exposure No exposure | ||||
| database | MPCD | 1 | -0.78706 | 0.52541 | 3.612 | 2.2440 | 0.1341 | database MPCD | ||||
| database | Marketscan | 1 | -0.02406 | 0.45729 | 6.311 | 0.0028 | 0.9580 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.35202 | 0.60798 | 1.713 | 4.9453 | 0.0262 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.72442 | 0.48494 | 2.183 | 2.2316 | 0.1352 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 2.17499 | 0.55905 | 2.465 | 15.1362 | 0.0001 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.43948 | 0.43610 | 2.884 | 10.8955 | 0.0010 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.87266 | 1.02930 | 1.291 | 0.7188 | 0.3965 | 0.418 | 0.056 | 3.142 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.64046 | 0.39280 | 6.327 | 2.6586 | 0.1030 | 1.897 | 0.879 | 4.097 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.49422 | 0.61066 | 3.226 | 0.6550 | 0.4183 | 1.639 | 0.495 | 5.425 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.39002 | 0.30717 | 2.296 | 1.6122 | 0.2042 | 1.477 | 0.809 | 2.697 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) | |
| SEX | F | 1 | -0.55576 | 0.27417 | 4.720 | 4.1089 | 0.0427 | 0.574 | 0.335 | 0.982 | Administrative Sex F | |
| indHospInf | 1 | -2.59359 | 0.66196 | 1.223 | 15.3513 | <.0001 | 0.075 | 0.020 | 0.274 |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.617 | 0.664 | 3.936 |
| exposure No exposure vs TNF At database=MPCD | 2.748 | 1.321 | 5.716 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.863 | 0.585 | 1.273 |
| exposure No exposure vs TNF At database=Marketscan | 1.317 | 0.960 | 1.805 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.418 | 0.189 | 0.925 |
| exposure No exposure vs TNF At database=Medicare | 0.312 | 0.149 | 0.656 |
| modelIncidenceOutcomes.sas |
| --- AS project --- |
| Model Information | |
|---|---|
| Data Set | WORK.ANALYTICDATASET |
| Dependent Variable | daysAtRisk |
| Censoring Variable | censor |
| Censoring Value(s) | 1 |
| Weight Variable | iptwStabilized |
| Ties Handling | EFRON |
|
|
|---|
| Class Level Information | |||||
|---|---|---|---|---|---|
| Class | Value | Design Variables | |||
| exposure | DMARD or NSAID | 1 | 0 | ||
| No exposure | 0 | 1 | |||
| TNF | 0 | 0 | |||
| database | MPCD | 1 | 0 | ||
| Marketscan | 0 | 1 | |||
| Medicare | 0 | 0 | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | 0 | 0 | 0 |
| Low (<2.5 mg/d) | 0 | 1 | 0 | 0 | |
| Medium-High (5-10 mg/d) | 0 | 0 | 1 | 0 | |
| Medium-Low (2.5-5 mg/d) | 0 | 0 | 0 | 1 | |
| None | 0 | 0 | 0 | 0 |
| Summary of the Number of Event and Censored Values |
|||
|---|---|---|---|
| Total | Event | Censored | Percent Censored |
| 26922 | 484 | 26438 | 98.20 |
| Convergence Status |
|---|
| Convergence criterion (GCONV=1E-8) satisfied. |
| Model Fit Statistics | ||
|---|---|---|
| Criterion | Without Covariates |
With Covariates |
| -2 LOG L | 5177.493 | 5144.100 |
| AIC | 5177.493 | 5168.100 |
| SBC | 5177.493 | 5218.285 |
| Testing Global Null Hypothesis: BETA=0 | |||
|---|---|---|---|
| Test | Chi-Square | DF | Pr > ChiSq |
| Likelihood Ratio | 33.3934 | 12 | 0.0008 |
| Score (Model-Based) | 29.7274 | 12 | 0.0031 |
| Score (Sandwich) | 116.6802 | 12 | <.0001 |
| Wald (Model-Based) | 27.9911 | 12 | 0.0055 |
| Wald (Sandwich) | 147.7413 | 12 | <.0001 |
| Joint Tests | |||
|---|---|---|---|
| Effect | DF | Wald Chi-Square | Pr > ChiSq |
| exposure | 2 | 9.3619 | 0.0093 |
| database | 2 | 4.9917 | 0.0824 |
| exposure*database | 4 | 18.4850 | 0.0010 |
| meanPredEqDoseCat | 4 | 1.6634 | 0.7974 |
| Note: | Under full-rank parameterizations, Type 3 effect tests are replaced by joint tests. The joint test for an effect is a test that all of the parameters associated with that effect are zero. Such joint tests might not be equivalent to Type 3 effect tests under GLM parameterization. |
| Analysis of Maximum Likelihood Estimates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | DF | Parameter Estimate |
Standard Error |
StdErr Ratio |
Chi-Square | Pr > ChiSq | Hazard Ratio |
95% Hazard Ratio Confidence Limits |
Label | |||
| exposure | DMARD or NSAID | 1 | -1.01958 | 0.44314 | 0.554 | 5.2937 | 0.0214 | exposure DMARD or NSAID | ||||
| exposure | No exposure | 1 | -1.22473 | 0.40958 | 0.671 | 8.9412 | 0.0028 | exposure No exposure | ||||
| database | MPCD | 1 | -0.68769 | 0.52675 | 2.203 | 1.7044 | 0.1917 | database MPCD | ||||
| database | Marketscan | 1 | 0.07283 | 0.44980 | 2.806 | 0.0262 | 0.8714 | database Marketscan | ||||
| exposure*database | DMARD or NSAID | MPCD | 1 | 1.51212 | 0.63278 | 0.614 | 5.7104 | 0.0169 | exposure DMARD or NSAID * database MPCD | |||
| exposure*database | DMARD or NSAID | Marketscan | 1 | 0.83774 | 0.49445 | 0.587 | 2.8706 | 0.0902 | exposure DMARD or NSAID * database Marketscan | |||
| exposure*database | No exposure | MPCD | 1 | 2.12580 | 0.56504 | 0.756 | 14.1543 | 0.0002 | exposure No exposure * database MPCD | |||
| exposure*database | No exposure | Marketscan | 1 | 1.46020 | 0.45427 | 0.713 | 10.3325 | 0.0013 | exposure No exposure * database Marketscan | |||
| meanPredEqDoseCat | High (10+ mg/d) | 1 | -0.45518 | 1.00530 | 0.818 | 0.2050 | 0.6507 | 0.634 | 0.088 | 4.550 | meanPredEqDoseCat High (10+ mg/d) | |
| meanPredEqDoseCat | Low (<2.5 mg/d) | 1 | 0.28256 | 0.26554 | 2.054 | 1.1323 | 0.2873 | 1.327 | 0.788 | 2.232 | meanPredEqDoseCat Low (<2.5 mg/d) | |
| meanPredEqDoseCat | Medium-High (5-10 mg/d) | 1 | 0.23986 | 0.48034 | 1.121 | 0.2494 | 0.6175 | 1.271 | 0.496 | 3.259 | meanPredEqDoseCat Medium-High (5-10 mg/d) | |
| meanPredEqDoseCat | Medium-Low (2.5-5 mg/d) | 1 | 0.14741 | 0.34408 | 1.250 | 0.1835 | 0.6683 | 1.159 | 0.590 | 2.275 | meanPredEqDoseCat Medium-Low (2.5-5 mg/d) |
| Hazard Ratios for exposure | |||
|---|---|---|---|
| Description | Point Estimate | 95% Wald Robust Confidence Limits |
|
| exposure DMARD or NSAID vs TNF At database=MPCD | 1.636 | 0.674 | 3.972 |
| exposure No exposure vs TNF At database=MPCD | 2.462 | 1.188 | 5.101 |
| exposure DMARD or NSAID vs TNF At database=Marketscan | 0.834 | 0.574 | 1.212 |
| exposure No exposure vs TNF At database=Marketscan | 1.266 | 0.927 | 1.728 |
| exposure DMARD or NSAID vs TNF At database=Medicare | 0.361 | 0.151 | 0.860 |
| exposure No exposure vs TNF At database=Medicare | 0.294 | 0.132 | 0.656 |
| modelIncidenceOutcomes.sas |