List all Reports for an Institute or Center for a particular year
All Annual Reports for NIMH for reporting year 2016
92 Annual Reports
Investigator-Initiated Project
1.
MH000478 (2016) Neural Mechanisms of Learning and Memory in Vision
Mortimer Mishkin, PhD
The essential circuit for both item and associative stimulus recognition in any given sensory modality consists of the relevant cortical sensory processing stream(s), the medial temporal rhinal cortex, the ventromedial prefrontal cortex, and the medial dorsal nucleus of the thalamus. Context-free re ...
2.
MH000889 (2016) Dysregulation of Protein Synthesis in Fragile X Syndrome and Other Developmental Disorders
Carolyn E Beebe, PhD
The protocol involved in this project is 06-M-0214, NCT00362843.
During the 2016 funding period, we addressed the following: 1) rCPS measured with the L-1-C-11leucine PET method in patients with FXS and healthy volunteers sedated with dexmedetomidine, 2) The effects of treatment with metformin on ...
3.
MH001090 (2016) Studies of Central Nervous System Functional Anatomy
Miles Herkenham, PhD
Chronic psychosocial stress has been implicated in the etiology and progression of psychiatric disorders such as major depression and post-traumatic stress disorder (PTSD). In mice, we study the effects of psychosocial stress in a conflict paradigm that leads to behavioral alterations such as defici ...
4.
MH001101 (2016) Neural Mechanisms of Learning and Memory in Audition
Mortimer Mishkin, PhD
Several diverse pieces of evidence suggest the possibility that auditory long-term memory may require the assistance of the oromotor system. The first set of findings comes from a series of studies carried out on the 3-generational KE family, half of whose members suffer from an inherited speech and ...
5.
MH002032 (2016) Neural Coding of Visual Stimuli
Barry J Richmond, MD
In their classic works, Hubel and Wiesel studied the responses of Primary Visual Cortex (V1) neurons by showing bright or dark bars of light as visual stimuli. Movshon et al. used smoothed alternating bright and dark bars, sine wave gratings, as stimuli. With all such stimuli, the strength of the ne ...
6.
MH002035 (2016) Functional Anatomy of Perceptual and Attentional Systems in the Primate Brain
Leslie G Ungerleider, PhD
A typical scene contains many different objects that compete for neural representation due to the limited processing capacity of the visual system. At the neural level, competition among multiple objects is evidenced by the mutual suppression of their visually evoked responses. The competition among ...
7.
MH002039 (2016) Pharmacology of Stimulus Memory and Habit Formation
Mortimer Mishkin, PhD
The memory impairment associated with Alzheimers disease has long been associated with a loss in acetylcholine function and pathophysiology of the entorhinal/perirhinal, or rhinal cortex. In monkeys, lesions of this region as well as cholinergic deafferentation lead to severe memory deficits. We rec ...
8.
MH002386 (2016) Chemical Coding of Neurotransmission
Lee E Eiden, PhD
The neuropeptide slow transmitter PACAP (pituitary adenylate cyclase activating polypeptide) is released at synapses that transduce stress responses to the brain, and mediate homeostatic and allostatic adjustments to stress by the organism. The catecholamine transmitter DA (dopamine) is released at ...
9.
MH002497 (2016) Functional Organization of the Cerebral Cortex and Basal Ganglia
Charles R Gerfen, PhD
Advances in molecular genetic techniques are revealing new details of the neuroanatomical organization of brain circuitry and the functional role of these circuits in behavior. Engineered viral vector constructs have been developed to label axonal projections of targeted neurons with unpreceden ...
10.
MH002498 (2016) Roles of Oxytocin and Vasopressin in Brain
Walter Scott Young, MD, PhD
--We continued our studies of the CA2 region of the hippocampus where the Oxtr and Avpr1b are located. The CA2 area is an important, although relatively unexplored, component of the hippocampus. We are studying the role of various receptors and in the CA2 by crossing floxed receptor lines with Oxtr ...
11.
MH002537 (2016) Psychobiology and Treatment of Perimenopausal Mood Disorders
Peter J Schmidt, MD
This report includes work arising from the following clinical protocols: NCT00030147, NCT00060736, NCT00001231, and NCT00001322.
The menopause transition is accompanied by a decrease in quality of life (QOL) measures for some women, and several randomized controlled trials of menopausal hormone th ...
12.
MH002581 (2016) Childhood Onset Schizophrenia
Judith L Rapoport, MD
In comparison with adult onset schizophrenia patients, childhood onset patients have a greater number of pre-psychotic developmental disorders. One fifth of our COS cases have earlier forms of autism spectrum disorder, and one third have motor, speech, language, attention or impulse related developm ...
13.
MH002588 (2016) The Neural Foundations for Memory and Social Cognition In The Human Brain
Alex Martin, PhD
This past year we have continued to focus on a major part of long-term memory, termed semantic memory, that is composed of general information, such as facts, ideas, and the meaning of objects and words. We are particularly interested in characterizing the neural substrate mediating object and word ...
14.
MH002619 (2016) Neural Mechanisms of Motivation and Reward
Barry J Richmond, MD
When we choose one item from several alternatives, we consider their values from amount of reward and the amount of work needed to obtain them. To study the neuronal mechanism of such a decision-making, we developed a decision-making schedule task and recorded single unit activity from monkey orbito ...
15.
MH002652 (2016) Imaging of Neuropsychiatric Disorders with Developmental and Genetic Mechanisms
Karen F Berman, MD
The core aim of this project is to elucidate the nature, molecular foundations, underlying neurochemistry, and clinical correlates of neural systems-level dysfunction in schizophrenia. Toward that end, this year, the Clinical and Translational Neuroscience Branch has successfully executed comprehens ...
16.
MH002666 (2016) Evaluation and Treatment of Obsessive Compulsive and Related Disorders
Susan Elizabeth Swedo, MD
Obsessive-compulsive disorder (OCD) affects 1-2% of children and adolescents, causing significant distress and impairments from the unrelenting obsessional thoughts and compulsive behaviors. A unique subgroup of children with OCD has been identified on the basis of the acuity of their symptom onset. ...
17.
MH002685 (2016) Peptide Receptor Systems
Theodore B Usdin, MD, PhD
Following discovery of the neuropeptide Tuberoinfundibular Peptide of 39 residues (TIP39) and its receptor, the Parathyroid Hormone Receptor 2 (PTH2R) the section focused on investigation of their biological roles. Neuroanatomical mapping showed synthesis of TIP39 in discrete neuronal groups in the ...
18.
MH002717 (2016) Neuroimaging of Brain Circuits and Molecular Mechanisms in Normal Cognition
Karen F Berman, MD
The Clinical and Translational Neuroscience Branch continues to make advances on several fronts in order to delineate the neurochemical, neurogenetic, and neuropsychological contributions to neural systems function and development relevant to mental illness. We have embarked on data collection for t ...
19.
MH002736 (2016) Neural Substrates of Stimulus Recognition and Association Memory
Elisabeth Adams Murray, PhD
The prevailing model of amnesia holds that it depends on damage to a group of loosely related structures, collectively called the medial temporal lobe (MTL). One influential theory holds that these areas work together as a single functional unit. According to this theory, the structures in the MTL ...
20.
MH002768 (2016) Subcellular Compartmentalization of Neuronal Gene Expression
Barry Bernard Kaplan, PhD
Although once highly controversial, it is now well-accepted that there exists a diverse population of mRNAs and non-coding microRNAs in the distal structural/functional domains of the neuron to include the dendrite, axon, and presynaptic nerve terminal. It has also become well-established that prot ...
21.
MH002778 (2016) The Phenomenology and Neurophysiology of Juvenile Bipolar Disorder
Ellen Leibenluft, MD
Since the beginning of this project we have screened over 3000 subjects for this study. We have enrolled approximately 210 youth with bipolar disorder (BD), 310 subjects at risk for BD because they have a parent or sibling with the illness, and 115 adults with BD. This year, approximately 25 new sub ...
22.
MH002781 (2016) fMRI Studies Of Pediatric Mood And Anxiety Disorders
Daniel Pine, MD
This work is conducted under protocol 01-M-0192, NCT00018057.
We are using functional magnetic resonance imaging (fMRI) to examine neurocognitive correlates of pediatric anxiety disorders. Through ongoing collaborative studies, we also have increasingly compared findings in these syndromes with fin ...
23.
MH002782 (2016) fMRI Studies Of Risk For Mood And Anxiety Disorders In Children
Daniel Pine, MD
This work is conducted under protocol 03-M-0186, NCT00060775.
In this project, our group is examining biological aspects of risk for mood and anxiety disorders in children. Such work has major public impact. By identifying biological risks in children, information on novel treatments and preventati ...
24.
MH002783 (2016) Functional MRI Method Development
Peter A Bandettini, BS, PhD
Protocol number 93-M-0170, NCT00001360
The Section on Functional Imaging Methods (SFIM) has advanced functional MRI (fMRI) methodology through development of processing and acquisition methods and research on the underlying mechanisms behind the fMRI signal. Our recent work has focussed on assess ...
25.
MH002784 (2016) Neurogenesis in the Adult Brain
Heather A Cameron, PhD
This project focuses on the interactions between experience and adult neurogenesis in the hippocampal region of the brain. We are interested in understanding how experiences, including learning and stressful experiences, regulate adult neurogenesis and how the new neurons alter responses in these si ...
26.
MH002786 (2016) The Pathophysiology and Treatment of Children with Severe Irritability
Ellen Leibenluft, MD
Given concerns about the appropriate diagnosis for children with chronic, severe irritability, we defined the syndrome of severe mood dysregulation(SMD)to capture youth with extremely severe irritability and symptoms of hyperarousal. Our SMD phenotype formed the basis for the new pediatric diagnosis ...
27.
MH002793 (2016) PET Radiopharmaceutical Sciences
Victor W Pike, PhD
The Molecular Imaging Branch (MIB) aims to exploit positron emission tomography (PET) as a radiotracer imaging technique for investigating neuropsychiatric disorders, such as autism, depression, addiction, schizophrenia, and Alzheimer's Disease (AD). Fundamental to this mission is the development of ...
28.
MH002795 (2016) Translational Evaluation of PET Radiotracers
Robert Innis, MD
Examples of progress made during the prior year are summarized below.
1) Efflux transporters at the blood-brain barrier can decrease the entry of drugs and increase the removal of those molecules able to bypass the transporter. This issue is important because overexpression of efflux transporter ...
29.
MH002797 (2016) Neuronal avalanches in the neocortex
Dietmar Plenz, PhD
1. Critical brain dynamics are increasingly recognized to be important in cortex function. We have expanded on our previous finding of fluctuation analysis as a marker for critical dynamics in neuronal systems. Taking advantage of a data base in Freiburg, Germany on long-term recordings from human ...
30.
MH002798 (2016) The Psychophysiology of Fear and Anxiety
Christian Grillon, PhD
Our approach is to elucidate normative psychological and neurobiological mechanisms of fear and anxiety in non-anxious individuals to identify which of these mechanisms are perturbed in anxious people (i.e., individuals with an anxiety disorder). Fear is an adaptive response to threat that enables o ...
31.
MH002800 (2016) Identifying Neural Substrates of Behavior in Drosophila Melanogaster
Benjamin H White, PhD
Insect ecdysis sequences represent a simple, robust, and tractable model for studying the neuromodulatory mechanisms that govern behavior. Because initiation of an ecdysis sequence involves a profound shift in behavioral priorities, study of these sequences offers the opportunity to understand the n ...
32.
MH002803 (2016) Magnetic Resonance Spectroscopy and Imaging Studies of Brain Functions
Jun Shen, PhD
The goals of this research are to develop advanced MRS and imaging techniques and to apply them and other complementary methods to studying brain metabolism, neurotransmission and enzyme activity. MRS allows measurement of neurotransmission of glutamate and GABA in vivo, which play important roles i ...
33.
MH002804 (2016) Family Study of Affective and Anxiety Spectrum Disorders
Kathleen R Merikangas, PhD
The major aims of this project have been accomplished through the establishment of a large communitybased family study of adult probands who participate in comprehensive clinical and biologic assessments followed by comparable evaluations of their adult and child relatives. Recruitment of probands ...
34.
MH002810 (2016) Functional Genomics of Bipolar Disorder
Francis Joseph McMahon, MD
NCT00001174
In order to better interpret the impact of genetic variation on the brain biology of bipolar disorder, we are pursuing a variety of functional genomics studies, including brain imaging, microarray gene expression and RNA-seq in post-mortem brain tissue, and cellular phenotyping of neu ...
35.
MH002838 (2016) Neurophysiology of Visual Perception
David A Leopold, PhD
Human vision takes center stage in our complex cognitive interaction with the world. It may be seen as an accident of nature, and atypical among mammals, that human vision is so advanced. As large-brained, large-eyed primates, humans have come to rely strongly upon vision, as it carries with it many ...
36.
MH002843 (2016) Identification of Genes Involved in Major Mood Disorders
Francis Joseph McMahon, MD
NCT00001174
Starting in 1993, in collaboration with 10 academic centers across the US, we recruited a large sample of over 3,000 individuals with bipolar or other mood disorders. All participants did a diagnostic interview and provided a blood sample for DNA analysis. DNA and clinical data are av ...
37.
MH002844 (2016) Genetic Determinants of Antidepressant Response
Francis Joseph McMahon, MD
NCT00088699
Strong evidence from family and twin studies demonstrates that major depressive disorder (MDD) is heritable, yet there has been limited progress in identifying the actual genes involved. A separate, perhaps overlapping set of genes is expected to play a role in individual variation in ...
38.
MH002852 (2016) Clinical Evaluation of PET Radiotracers
Robert Innis, MD
1. We found that to measure translocator protein (TSPO) density in Alzheimers Disease (AD) and control subjects, a simple ratio method (standardized uptake value ratio, SUVR) can substitute for, and may even be more sensitive than, absolute quantitation. We also found that TSPO binding increases wit ...
39.
MH002857 (2016) Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect
Carlos Alberto Zarate, MD
This Report involves work collected under protocol 04-M-0222 (NCT00088699).
Our research suggests that the glutamatergic system is involved in the mechanism of action of rapid antidepressant response. In addition, this system may be a feasible target for developing treatments that have rapid and ...
40.
MH002860 (2016) Emotional Dysfunction and Childhood Behavioral Disturbance
Robert James Richard Blair, PhD
This project has established a series of core neuro-biological findings regarding the basis of Conduct Disorder (CD). Over the past year, we have particularly concentrated on forms of function that are compromised in youth with CD and then examined what specific symptom sets are consequent on these ...
41.
MH002863 (2016) Multimodal Neuroimaging of Gene-Brain Relationships in Williams Syndrome
Karen F Berman, MD
The Clinical Translational Neuroscience Branch continues to work toward discovery of novel genetic contributions to brain structure, function and clinically relevant behavior and cognition, through execution of an ongoing series of multimodal neuroimaging studies of individuals with copy number vari ...
42.
MH002865 (2016) Reproductive Endocrine Related Mood Disorders-Differential Sensitivity
Peter J Schmidt, MD
This report includes work arising from the following clinical protocols: NCT00005011, NCT00056901, NCT00059228, NCT00082043, NCT00100360, NCT00001177, NCT00001259, and NCT00001481
Overlapping co-morbidities between premenstrual dysphoric disorder (PMDD) and postpartum depression (PPD) have led to s ...
43.
MH002868 (2016) Clinical and Behavioral Phenotyping of Autism and Related Disorders
Susan Elizabeth Swedo, MD
Autism spectrum disorder is currently defined as a single disorder characterized by impairments in social communication and the presence of restricted interests and repetitive behaviors. However, there is mounting evidence that autism spectrum disorder represents a collection of overlapping neurodev ...
44.
MH002874 (2016) The Neuroregulatory Effects of Gonadal Steroids in Humans
Peter J Schmidt, MD
This report includes work arising from the following clinical protocols: NCT00026832, NCT00100360, NCT00001177, and NCT00001322.
Behavioral observations from this and a related study in healthy young men, show that clinically significant depressive symptoms are rare accompaniments of induced hypogo ...
45.
MH002881 (2016) Molecular Mechanisms of Synapse Development and Plasticity
Zheng Li, PhD
1. Synapses can change their efficacy through synaptic plasticity. Long-lasting forms of synaptic plasticity (such as long-term potentiation and long-term depression of synaptic transmission) are important cellular mechanisms underlying information storage in the brain and the establishment of prope ...
46.
MH002882 (2016) Characterizing the Function of miRNAs in Neural Development, Synaptic Plasticity and Schizophrenia.
Zheng Li, PhD
1.  The temporal dynamics of gene expression is conferred by transcriptional and posttranscriptional regulation. microRNAs (miRNAs) play important roles in the posttranscriptional regulation of gene expression during brain dev ...
47.
MH002886 (2016) Neural mechanisms of reward processing and emotion
Elisabeth Adams Murray, PhD
The amygdala, OFC and MFC contribute to learning, in part, by evaluating feedback. In an effort to extend our understanding of the physiological mechanisms underlying affective processing, we developed an fMRI paradigm to reveal blood-oxygen-level dependent (BOLD) responses to visual images that sig ...
48.
MH002887 (2016) Neural Substrates of Reward Processing and Emotion
Elisabeth Adams Murray, PhD
Previous work on this project has shown that value-based decision making requires both the OFC and the amygdala. We have used two kinds of tasks to investigate their mechanisms: (1) standard probabilistic and deterministic 2- and 3-choice visual discrimination learning tasks and (2) tasks that requi ...
49.
MH002890 (2016) Integrating EEG/MEG and fMRI
Richard Coppola, SB, DSc
Our earlier basic studies have shown that MEG recordings during cognitive tasks have the ability to localize brain activity in comparable fashion to functional MRI. In specific, reduction in power in the beta frequency band at the cortex in general agrees with BOLD activation results. However, elect ...
50.
MH002893 (2016) Learning and plasticity in the human brain
Christopher Ian Baker, PhD
The primary goals of this research are i) to establish how learning impacts the structure and function of the brain, and ii) to determine how learning can be modulated by factors such as feedback (positive or negative). Over the past year we have focused equally on both of these goals.
1) Impact ...
51.
MH002896 (2016) The Neural Basis of Functional MRI Responses
David A Leopold, PhD
Functional MRI (fMRI) has had perhaps the strongest influence of any neuroscience method on the public conception of how the brain operates. For the past decade or longer, colorful maps have adorned science articles in the popular press, raising the public awareness of neuroscientific progress. The ...
52.
MH002897 (2016) Molecular and Cellular Mechanisms of Experience-Dependent Cortical Processing
Kuan Hong Wang, PhD
Our brain can be considered as a type of information processing system like a computer, where input signals need to be first detected and properly represented, then integrated for decision-making and output control. A unique feature of the brain as an information processing system lies in its adapt ...
53.
MH002898 (2016) Social Processing and Neural Plasticity
David A Leopold, PhD
Our social world is comprised of complex stimuli, relationships, rules, and emotions. Thus the social circuitry in the primate brain is a widespread set of regions that touches on each of these operations. Some of these subregions appear highly specialized, such as the multiple cortical areas in h ...
54.
MH002909 (2016) Object, face, body and scene representations in the human brain
Christopher Ian Baker, PhD
The goal of this research is to understand how we see what we see: how does the brain analyze the light falling on the retina of the eye to encode a world full of objects, people and things?
During the past year we have focused on the perception of complex visual stimuli, in particular real-worl ...
55.
MH002914 (2016) Treatment of Medical Conditions among Individuals with Autism Spectrum Disorders
Susan Elizabeth Swedo, MD
Autism spectrum disorder (ASD) is defined by deficits of social communication and the presence of restrictive and/or repetitive behaviors. Recent epidemiologic studies have documented an increase in the number of children identified with autistic symptoms, with some reports suggesting that as many a ...
56.
MH002917 (2016) Office of the Scientific Director
Susan G Amara, PhD
The NIMH Division of Intramural Research Programs' (IRP) scientists conduct research ranging from studies into the mechanisms of normal brain function at the behavioral, systems, cellular, and molecular levels, to clinical investigations into the diagnosis, treatment and prevention of mental illness ...
57.
MH002918 (2016) Functional Anatomy of Face Processing in the Primate Brain
Leslie G Ungerleider, PhD
Lesions of inferior temporal (IT) cortex in humans can result in the syndrome termed prosopagnosia, an inability to recognize familiar faces. Single-cell recordings from IT cortex of monkeys have revealed the existence of neurons that are selectively activated by visual images of faces. Additionally ...
58.
MH002920 (2016) The Cognitive Neuroscience of Autism Spectrum Disorders
Alex Martin, PhD
This past year we have continued to evaluate the neural characteristics, and associated behavioral consequences, of Autism Spectrum Disorders (ASD).
Prevailing theories suggest that ASD results from impaired brain communication due to aberrant timing or coordination of neuronal firing patterns ( ...
59.
MH002922 (2016) Psychiatry Consultation Liaison Service Research
Maryland Pao, MD
The three areas of OCD research are:
Suicide Risk in the Medical Setting
Suicide is an international public health threat. In the U.S., it is the 2nd leading cause of death for youth and the 10th leading cause of death for adults. As suicide risk screening becomes a national priority for medical ...
60.
MH002927 (2016) Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders
Carlos Alberto Zarate, MD
This Report involves work collected under protocols 01-M-0254 (NCT00024635 ); 08-M-0196 (NCT00759395); 08-M-0150 (NCT00697268); 14-M-0085 (NCT02122562); 07-M-0021 (NCT00397111); 14-M-0041 (NCT02049385); and 07-M-0152 (NCT00472576), 09-M-N230; 15-M-0151 (NCT 02484456), 15-M-0188 (NCT02543983).
Res ...
61.
MH002928 (2016) Frontal Striatal Systems and Dopamine in Normal and Pathological Behavior
Bruno B Averbeck
Our lab uses a combination of neurophysiology, pharmacology and functional imaging to examine the role of frontal striatal systems in behavior. Several of our experiments are motivated by studies in patient groups that show that patients have deficits on particular tasks. We then study those tasks i ...
62.
MH002929 (2016) Developing New Statisical Methods to Detect Common and Rare Variants Involved in Neuropsychiatric Disorders
Yin Yao Shugart, PhD
Our goal is to develop new analytic tools that can be used to identify genetic variation more efficiently and accurately than the existing methods and then test them in the datasets of psychiatric disorders or other complex human diseases. We have been actively working with both intramural and extra ...
63.
MH002930 (2016) Developing Statistics Methods to Detect Common and Rare Genetics Variants in Human Complex Pedigrees
Yin Yao Shugart, PhD
Unlike whole genome-wide association studies (GWAS) which can only discover variations in DNA that are frequent in the populations (greater than 1%), both exome sequencing and whole-genome sequencing may have the advantage of testing comprehensively the role of coding variation, both common and rare ...
64.
MH002933 (2016) Endocrine and Neurobiologic Events Accompanying Puberty
Peter J Schmidt, MD
This report includes work arising from the following clinical protocol: NCT01434368.
Recruitment efforts for this longitudinal study continue and we have completed approximately 90% of our planned enrollment of for our first cohort of 12-13 year old children and approximately 60% of our planned enr ...
65.
MH002934 (2016) Integrating fMRI and Next-Generation-Sequencing Data to Identify Schizophrenia Biomarkers
Yin Yao Shugart, PhD
Summary
Using the sparse representation based variable selection (SRVS) based integrated analysis of gene expression and SNP data sets, we hope to identify a set of potential genomics markers for schizophrenia. Our initial analysis provided encouraging results. Therefore, we are seeking more sam ...
66.
MH002935 (2016) Mathematical and Statistical Analysis Techniques for in Vivo Imaging Studies
Carolyn E Beebe, PhD
In the current year we have refined our data analysis methods for estimation of rates of cerebral protein synthesis (rCPS) with L-1-C-11leucine and PET. Because rCPS tends to change only modestly under different physiological conditions, it is essential that the analyses achieve the highest possible ...
67.
MH002936 (2016) Cerebral Protein Synthesis During Sleep and Memory Consolidation
Carolyn E Beebe, PhD
The protocol involved in this project is 09-M-0123, NCT00884702.
During the FY 2016 funding period, we addressed the following:
In collaboration with our colleagues from the Walter Reed Army Institute of Research (T Balkin) and NINDS (D. Picchioni), we use the L-1-C-11leucine PET method to ...
68.
MH002942 (2016) Multimodal Imaging: Genetic and Environmental Effects in Neuropsychiatry
Karen F Berman, MD
In order to better understand how schizophrenia risk genetics operate at the cognitive and neural systems level, our recent work under this project has focused on (1) identifying novel phenotypes that distinguish both people with schizophrenia and unaffected family members from unrelated healthy ind ...
69.
MH002946 (2016) Structure, Function and Pharmacology of Neurotransmitter Reuptake Systems
Susan G Amara, PhD
Our laboratory has shown that amphetamines trigger the internalization of the dopamine transporter (DAT) by a series of intracellular events that are distinct from the generally established actions of amphetamines to inhibit dopamine (DA) uptake or to increase DA efflux. We have found that when appl ...
70.
MH002948 (2016) Cerebral Protein Synthesis as a Measure of Degenerative Changes in a Transgenic Rat Model of Alzheimer's Disease
Carolyn E Beebe, PhD
During the 2016 funding period, we carried out studies to measure rCPS with the autoradiographic L-1-C-14leucine method in cohorts of WT and TgF344-AD at six, 14, and 18 months of age. In these animals we also measured activity by means of open field behavior, memory by means of the T-maze, olfacti ...
71.
MH002949 (2016) Developmental Neurogenomics Unit
Armin Raznahan
This work is conducted under protocol 89-M-0006 (NCT00001246).
The Developmental Neurogenomics Unit (DNU) was established in October 2015, and work during the past year was focused on completion of basic infrastructural tasks including physical relocation and furnishing of the laboratory, recruit ...
72.
MH002950 (2016) Dissecting the stress circuits of the paraventricular nucleus of the thalamus
Mario Alexander Penzo
This fiscal year we successfully launched our research program aimed at studying the role of the PVT in stress processing and the control of stress susceptibility. This included designing and setting up laboratory equipment, hiring and training laboratory staff, and conducting pilot studies. To begi ...
73.
MH002951 (2016) Neural Circuits underlying the control of Executive and Emotional Behavior
Yogita Chudasama, PhD
Broadly speaking, much of our work has been directed toward understanding prefrontal deficits. In humans, executive function is known to rely on an intact prefrontal cortex, with famous patients such as Phineas Gage illustrating the range of inhibitory control, decision-making, and socioemotional de ...
74.
MH002953 (2016) Population-Based Epidemiologic Research
Kathleen R Merikangas, PhD
During the past year we have conducted a number of studies addressing the aims above.
Although the NCS-A survey was conducted 10 years ago, it remains the richest source of data on DSM mental disorders and risk factors in a nationally-representative sample of U.S. adolescents. During the past ye ...
75.
MH002954 (2016) Motor Activity Research Consortium for Health (mMarch)
Kathleen R Merikangas, PhD
There is growing interest in studying the environmental, biologic and genetic correlates of the components of motor activity as well as the relationships between motor activity with sleep, exercise, mood, and cognitive functioning. Aggregation of the findings across these studies is complicated by t ...
76.
MH002955 (2016) Non-invasive Neuromodulation Unit (NNU)
Sarah Hollingsworth Lisanby
Newly opened this year, major accomplishments for the NNU were the recruitment of staff, installation and testing of neuromodulation equipment, training of staff, writing of software to implement experiments and collect and process data, and protocol development. We now have a fully functional noni ...
77.
MH002956 (2016) Patterns of neuronal activity underlying behavioral decisions
Mark H Histed, PhD
To understand how neuronal activity patterns give rise to behavior, we have adopted a new technology that extends a two-photon microscope to stimulate both single neurons and patterns of individual neurons. This approach opens the door to studying how animals' choices depend on patterns of neuronal ...
Scientific Core
1.
MH002884 (2016) Functional MRI Core Facility
Peter A Bandettini, BS, PhD
Protocol number 93-M-0170, NCT00001360
Space Utilization:
The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, 3TD, and 7T MRI scanners located within the NMR ...
2.
MH002888 (2016) Scientific and Statistical Computing Core
Robert Cox, PhD
The principal mission of the Core is to help NIH researchers with analyses of their fMRI (brain activation mapping) data. Along the way, we also help non-NIH investigators, mostly in the USA but also some abroad. Several levels of help are provided, from short-term immediate aid to long-term develop ...
3.
MH002889 (2016) NIMH MEG Core Facility
Richard Coppola, SB, DSc
The MEG Core staff works interactively with a large group of PI's in NIMH, NINDS and NIDCD for study design, task development, acquisition protocols, signal processing and data analysis. Procedures for data security, transfer and storage have been improved by moving the main data archive to the Heli ...
4.
MH002894 (2016) Magnetic Resonance Spectroscopy Core Facility
Jun Shen, PhD
As a noninvasive method for measuring concentration and distribution of chemicals in the living brain MRS is an important tool for studying brain function and disorders. However, robust measurement of MRS signals requires highly sophisticated design, implementation and maintenance of various MRS tec ...
5.
MH002899 (2016) Neurophysiology Imaging Facility Core: Functional and Structural MRI
David A Leopold, PhD
Research in nonhuman primates (NHP) is technically demanding. While many NHP researchers would, in principle, like to incorporate magnetic resonance imaging into their testing, it is often challenging or impossible given constraints on scanner availability and methodological hurdles. The NIF facil ...
6.
MH002901 (2016) Transgenic Resources for Neuroscience Research
James M Pickel, AB, PhD
The NIMH transgenic core facility has several major functions: 1) to produce transgenic research animals for neuroscience research, 2) to support research with associated techniques in genetic research in neuroscience, 3) to develop new transgenic techniques and model systems and 4) to engage in col ...
7.
MH002903 (2016) Procurement and Characterization of Postmortem Brain Tissue
Barbara K Lipska, PhD
Currently, the HBCC resources include brains from individuals with the following diagnoses (numbers of subjects listed in parentheses): Bipolar disorder (135), Non-psychiatric controls (311), Schizophrenia and schizoaffective disorder (193), Substance Abuse (23), Major depressive disorder (217), Oth ...
8.
MH002911 (2016) NIMH Instrumentation Core Facility
George Raphael Dold, MME, BSEE
Summary: This past year, our Section had the unique opportunity to support the research from various Labs & Sections within NIMH, NINDS, NICHD, and NCCIH. During the past twelve months, investigators from these labs and branches requested 499 formal projects from our staff. Each of these requests w ...
9.
MH002952 (2016) Rodent Behavioral Core: The Analysis of Behavior
Yogita Chudasama, PhD
Behavioral neuroscience links systems-level circuitry to behavior, cognition and emotion, and is thus critical for understanding the afflictions that affect neuropsychiatric patients. Linking cognitive changes in a behaving rat or mouse to targeted manipulations of neural circuitry requires the conv ...
Clinical Support Services
1.
MH002912 (2016) Office of the Clinical Director
Maryland Pao, MD
CLINICAL RESEARCH SUPPORT SERVICES: An important mission of the OCD is to ensure that subjects participating in NIMH protocols receive the highest quality clinical care. The OCD is responsible for oversight of all clinical aspects of the NIMH IRP including: 1) Risk Management/Patient Safety of the o ...
Clinical Training
1.
MH002939 (2016) Office of the Clinical Director-Psychiatry Clinical Research Training
Maryland Pao, MD
Clinical Fellowship Programs:
During FY16, there were eleven NIMH IRP residents/fellows. The academic year generally starts in July so this number includes new, current and departing trainees in our programs. Of the eleven trainees, four were in our PGY-4 ACGME accredited psychiatry residency prog ...
Animal Research Infrastructure
1.
MH002924 (2016) Veterinary Medicine Research Branch
James Raber, DVM, PhD
The NIMH Veterinary Medicine Research Branch (VMRB) has successfully provided veterinary medical, husbandry and research support to over twenty-six (26) principal investigators in the NIMH IRP with over fifty-four (54) active animal study protocols. In addition, the Branch has provided training and ...
New Space Activation & Commissioning
1.
MH002947 (2016) NIMH Space Activation and Commissioning
Susan G Amara, PhD
NIMH intramural scientists conduct research ranging from studies into the mechanisms of normal brain function at the behavioral, systems, cellular, and molecular levels, to clinical investigations into the diagnosis, treatment and prevention of mental illness. Researchers study conditions in adults ...
Education and Outreach
1.
MH002916 (2016) Office of Fellowship Training
Janet Elizabeth Clark
In fiscal year 2016 (FY16) OFT administered several ongoing educational events and programs for the IRP and established new training opportunities. The OFT processed personnel cases for approximately 320 fellows and 160 Special Volunteers and Collaborators. In support of the newly implemented Staff ...
Technology Transfer
1.
MH002925 (2016) Office of Technology Transfer
Jennifer S Wong
The Office of Technology Transfer Office (OTT) negotiates Material Transfer Agreements, Cooperative Research Development Agreements, Licenses, Collaboration Agreements, Confidential Disclosure Agreements, and Clinical Trial Agreements. We also provide guidance and assistance to NIMH researchers, eva ...


<substeps>
The <substeps>
element allows you to break a step down into a series of
separate actions, and should be used only if necessary. Try to describe the steps of a task
in a single level of steps. If you need to use more than one level of
<substep>
nesting, you should probably rewrite the task to simplify
it.
Category: Task elements


Senate re-introduces South West Development Commission
by The Eagle OnlineThe bill for the establishment of the South West Development Commission passed into first reading in the Senate on Thursday.
The bill was sponsored by Senator Ibikunle Amosun.
It is titled: “South West Development Commission.”
It was first presented in eight Senate.
The bill is coming 24 hours after the South East Development Commission was passed into first reading.
Previous Post
Just In: Senate swears-in Biodun Olujimi
Next Post
Over 30 African superstars to thrill fans at 6th AFRIMA music village


Raw Probely API authentication key.
Please use the credentialsId field instead, unless you understand the security implications of using this mechanism. Passing the API authentication token directly is not advised, unless it is properly secured using a secret storage mechanism, such as HashiCorp Vault.


CHRISTMAS CRACKER
Celtic WAG Helen Flanagan opens new M&D’s magical Santa Christmas wonderland
by Aidan SmithHELEN FLANAGAN was on hand to open M&D's magical Santa wonderland this year.
The Scots theme park has once again transformed into a winter wonderland packed with activities for the festive season.
Celtic WAG Flanagan arrived on a Christmas train as she welcomed guests to kick off the festive season.
Festive revellers can meet Santa in Scotland’s largest grotto, visit live reindeer and join storytelling sessions while watching enchanting animated Christmas scenes at the park.
Visitors can also skate under the stars on the M&D’s on Ice open air 25 meter ice rink from November 23 until January 5.
This year, Autism Friendly sessions are also being introduced for the first time allowing everyone a chance to enjoy a skate around the rink.
Anyone looking for seasonal treats can head to the Bavarian Bar for a hot mulled wine or spiced cider and grab a festive bite to eat in Santa’s Christmas Inn.
The Outdoor Festive Markets – also returning for 2019 – offer the perfect opportunity to purchase stocking fillers with an array of and craft gifts for sale.
Santa and his elves will also be making an appearance between Saturday December 21 and Tuesday December 24 at Guiseppe’s Coffee Shop, allowing families a chance to meet Santa for breakfast.
There’s also a chance to enjoy the park’s rides as part of the Festive Rides experience, where visitors can enjoy rides such as the Big Wheel and the Sleigh Ride for just £2 per ticket.
Matthew Taylor, managing director of M&D’s Theme Park, said: “Everyone at M&D’s is always very excited for Christmas and to celebrate, we’re expanding our Santa’s Magical Wonderland offering even more for 2019.
“With opportunities for the children to meet the Father Christmas himself at our grotto and a chance for adults to enjoy our Christmas markets and a skate session on our outdoor ice rink, there’s something for everyone at M&D’s this winter.
“We are also delighted to have added even more autism-friendly sessions this year so everyone can have an unforgettable festive experience.”


Queued: Async Python, Simplified¶
Queued is an open source async library, written in Python, that rethinks how we should write consumer/producer style code.
How to Install?¶
pip install queued
How to use it?¶
from queued import queued
@queued
def mah_high_performance_log(queued_items):
''' this logs input to a file in the background '''
with open('my_result.log', 'a') as f:
for item in queued_items:
f.write('{}\n'.format(item))
mah_high_performance_log('yay Im loggin!')
What does it do?¶
Decorating a function with @queued
by default does two things:
- The decorated function is placed in a separate thread and becomes nonblocking.
- The now backgrounded function is now fed inputs through a queue.
What is the benefit?¶
queued
allows you to put functions that have blocking operations in the background so your main thread or process can focus on the main task. This is beneficial for functions that you don’t need the return value from, like logging. Since queues preserve order though, you’ll still get the sequential benefits of straight line programming without the unordered mess or memory consumption that comes from just spawning off a background thread to do some job in the background.
Can I have multiple worker threads/processes for a queued
function?¶
Yes. Feeding queued
the workers
argument will tell queued
to create however many threads or processes you want to have watching the queue that feeds your function. CAUTION - This does mean that you will need to consider syncing issues for certain operations.
from queued import queued
from requests import get
# this will download up to 4 files at the same time
@queued(workers=4)
def download(queued_items):
for file_path, url in queued_items:
with open(file_path, 'w') as f:
for chunk in get(url).iter_content():
f.write(chunk)
download(('/tmp/google.html', 'https://google.com'))
Can I limit the size of the queues of each function?¶
Yes, the maxsize
argument allows you to limit the number of items that are in a function’s queue. If you top off the queue, the main thread will wait for the background thread/process to make room in the queue. This is handy if you have memory consumption concerns
from queued import queued
# all calls to result_logger will be non-blocking unless
# the background job has 10 objects in its queue
@queued(maxsize=10)
def result_logger(queued_items):
with open('my_result.log', 'a') as f:
for input_string in queued_items:
f.write(input_string + '\n')
result_logger('yay Im loggin!')
What happens when a queued function crashes?¶
queued
will log the error. If you want to specify the logger function that you want to send the log messages to, use the logger
argument. By default logger=logging.warning
.
from queued import queued
from requests import get
# this logs to a file in the background
@queued
def custom_error_logger(queued_items):
with open('my_result.log', 'a') as f:
for input_string in queued_items:
f.write(input_string + '\n')
# this will download links in the background
# and send error messages to result_logger
@queued(logger=custom_error_logger)
def download(queued_items):
for file_path, url in queued_items:
with open(file_path, 'w') as f:
for chunk in get(url).iter_content():
f.write(chunk)
download(('/tmp/google.html', 'https://google.com'))


Version 0.71!
Overview:
- Fixes in the game, launcher and lobby are now live.
- The patcher is now working as intended.
- Balance changes have been added.
- Basic attack adjusted per Class.
- Thief: Now based on DEX. (Backstab: STR)
- Warrior: Based on STR.
- Mage: Based on INT.
- Spell Changes
- Mage dagger no longer silenceable.
- Stun spell not triggering - fixed.
Class preview added.
Monster AI under development.
Players should redownload the patcher from the above link.
//chili. - 2013-12-16
Stats and Balancing.
Here is the current stat balance, from now on the balancing will use relative values.
|
CON |
STR |
DEX |
INT |
WIS |
MR |
PR |
| Mage
| 13.5 |
0.96 |
1.25 |
7.2 |
18.5 |
0.92 |
0.5 |
| Thief |
15.2 |
1.15 |
2.15 |
4.95 |
14.5 |
0.5 |
0.75 |
| Warrior |
21.0 |
1.95 |
1.25 |
3.5 |
12.0 |
0.5 |
1.25 |
Modifiers and Effects, Reference sheet.
- CON
- Gives health per point.
- Health regen increases.
- [Heal]: Increased effect..
- STR
- [Warrior-Basic]: attack damage.
- [Backstab]: Increased damage.
- [Basic-Thief] Thief ranged damage.
- [Magedagger]: Increased damage.
- [Backstab]: Increased Damage.
- [Telestrike]: Increased Duration.
- [Jumpstrike]: Increased Damage.
- [Passive: Mage]: Increases restored mana on-hit.
- DEX
- Increases movement speed.
- Increases attack speed.
- Adds physical resistance.
- [Poison Arrow]: Increased Duration.
- [Backstab]: Increased Damage.
- INT
- [Stun, Slow, Chaos]: Increased Damage.
- [Chaos]: Increased Heal.
- [Heal]: Increases Heal Slightly.
- [Basic Mage]: Increases damage.
- [Lifesteal] Increased heal, Increased damage.
- [Hiddendagger]: Increased Damage.
- [Stealth]: Increased Duration.
- [Spellstrike]: Increased Damage.
- [Mightystrikes]: Increased Damage.
- [Shield]: Increased Hits.
- WIS
- Increased mana pool.
- Increased mana regen.
- Decreases cooldowns
Additional class bonuses:
- Warrior has increased haste duration.
- Mage has decreased cooldowns and restores mana on-hit.
- Thief has invisibility and backstab.
//chili. - 2013-12-16
Version 0.7!
A new version has been released, featuring new player models and
some updated graphics. A few balance fixes have also been added
and minor improvements have been made to the patcher and lobby.
The warrior jumpstrike attack is still broken, a fix is soon
to be awaited.
Players should redownload the patcher from the above link.
//chili. - 2013-11-15
New Version
The version 6 has gone live sucessfully. Many bugfixes and improvements
have been incorporated. In this latest release the Patcher was updated,
it will now be more responsive. Small patches are planned for the lobby,
the lobby should soon send multiple attempts for connection and also
provide more feedback.
Big changes are planned for the game, a gamemode with scoring and round
winners. Mobs and bosses should be implemented, Player AI's should be
refined and tuned to scale better. Player AI's should also make use of
attributes, to make them really strong. The warrior AI is having a huge
nerf while we're buffing the thief AI and leaving the mage as is.
Players should redownload the patcher from the above link.
//chili. - 2013-09-01
More Shiny Stuff
More shiny stuff have been added. Arts such as a brand new playable
map, 15 fresh graphic effects. Player classes have been added, including
the Mage, Thief and Warrior. Each wielding the power of 5 unique abilities
and 3 basic abilities (basic attack, heal & haste). A MAP Editor was added
to the Toolset. Major changes and bugfixes including multiplayer support,
optimizations and Unicode support.
This version will come live week 20, The BETA Test will also begin
after this release has gone live, labeled as 'Beta 0.6', "EnterTheDungeon".
//chili. - 2013-05-14
Major Changes
Major changes has been committed. The suite was updated with
new tools: Game Lobby, Patcher & a KeyGen. Major changes to
game art, large engine improvements, art assets updated.
A Bandwidth of 3KB/s upstream is recommended (8 player).
A Bandwidth of 30KB/s downstream is recommended (8 player).
A Processor of 650Mhz Dual or 925Mhz Single
Integrated Graphics With Support for any of the
following, DirectX7, DX8, DX9, DX10, DX11 or OpenGL 2.0
The current release suffers from delays on network
play, this is intended UNTIL the post-BETA patch.
The delays will be disabled by flow reverse. ;-)
//chili. - 2013-05-08
First Version
The first version compiled for win32. All is running well.
This version is released as 'Pre-ALPHA 0.5', codename "JustGrass".
//chili. - 2013-04-30
Website Launched
The website was launched. - 2013-04-24
//chili.


{%extends 'main/base.html'%} {%block title%}NHS Admin Area{%endblock%} {% block content %} Welcome to the NHS Administration area! What would you like to do?


The header section at the beginning of every fatal error log file contains a brief description of the problem. The header is also printed to standard output and may show up in the application's output log.
The header includes a link to the HotSpot Virtual Machine Error Reporting Page, where the user can submit a bug report.
Example A-1 Sample Header from a Crash
# # An unexpected error has been detected by Java Runtime Environment: # # SIGSEGV (0xb) at pc=0x417789d7, pid=21139, tid=1024 # # Java VM: Java HotSpot(TM) Client VM (1.6.0-rc-b63 mixed mode, sharing) # Problematic frame: # C [libNativeSEGV.so+0x9d7] # # If you would like to submit a bug report, please visit: # http://bugreport.java.com/bugreport/crash.jsp #
Example A-1 shows that the VM crashed on an unexpected signal.
The next line describes the signal type, program counter (pc) that caused the signal, process ID and thread ID, as shown in Example A-2.
Example A-2 Header Format Second Line
# SIGSEGV (0xb) at pc=0x417789d7, pid=21139, tid=1024 | | | | +--- thread id | | | +------------- process id | | +--------------------------- program counter | | (instruction pointer) | +--------------------------------------- signal number +---------------------------------------------- signal name
The next line contains the VM version (Client VM or Server VM), an indication whether the application was run in mixed or interpreted mode, and an indication whether class file sharing was enabled as shown in Example A-3.
Example A-3 Header Format Third Line
# Java VM: Java HotSpot(TM) Client VM (1.6.0-rc-b63 mixed mode, sharing)
The next information is the function frame that caused the crash, as shown in Example A-4.
Example A-4 Header Format Fourth Line
# Problematic frame: # C [libNativeSEGV.so+0x9d7] | +-- Same as pc, but represented as library name and offset. | For position-independent libraries (JVM and most shared | libraries), it is possible to inspect the instructions | that caused the crash without a debugger or core file | by using a disassembler to dump instructions near the | offset. +----------------- Frame type
In this example, the "C" frame type indicates a native C frame. Table A-1 shows the possible frame types.
Table A-1 Frame Types
| Frame Type | Description |
|---|---|
|
C |
Native C frame |
|
j |
Interpreted Java frame |
|
V |
VM frame |
|
v |
VM-generated stub frame |
|
J |
Other frame types, including compiled Java frames |
Internal errors will cause the VM error handler to generate a similar error dump. However, the header format is different. Examples of internal errors are guarantee()
failure, assertion failure, ShouldNotReachHere()
, and so forth. Example A-5 shows the header format for an internal error.
Example A-5 Header Format for an Internal Error
# # An unexpected error has been detected by HotSpot Virtual Machine: # # Internal Error (4F533F4C494E55583F491418160E43505000F5), pid=10226, tid=16384 # # Java VM: Java HotSpot(TM) Client VM (1.6.0-rc-b63 mixed mode)
In the above header, there is no signal name or signal number. Instead the second line now contains Internal Error
and a long hexadecimal string. This hexadecimal string encodes the source module and line number where the error was detected. In general this "error string" is useful only to engineers working on the HotSpot Virtual Machine.
The error string encodes a line number and therefore it changes with each code change and release. A crash with a given error string in one release (for example, 1.6.0) might not correspond to the same crash in an update release (for example, 1.6.0_01), even if the strings match.
|
Note: Do not assume that a workaround or solution that worked in one situation associated with a given error string will work in another situation associated with that same error string. Note the following facts:
Therefore, the error string should not be used as the sole criterion when troubleshooting bugs. |


Blog
Plugins
Extensions
Services
wCheck.js
Classic:
one
two
three
four
one
two
three
four
one
two
three
four
one
two
three
four
one
two
three
four
one
two
three
four
one
two
three
four
one
two
three
four
Radial:
Inset:


Generate
1.Write a script that creates a number of div elements.Each div element must have the following
- Random width and height between 20px and 100px
- Random background color
- Random font color
- Random position on the screen (position:absolute)
- A strong element with text "div" inside the div
- Random border-radius
- Random border color
- Random border-width between 1px and 20px


GSoC Week 10 & 11 - The One with `solvify`
FiniteSet | list
ImageSet, | list (if `f` is periodic)
Union |
EmptySet | empty list
Others | None
Adding
domain
support.I added a
domain
argument toisolve
whose default value is the real domain (domain=S.Reals
). A few limitation to the conditions ofS.Infinity
andS.NegativeInfinity
followed.Another noticable point, from the point of implementation, was to deal with singularities and discontinuities of the given inequality. For this, I used the
continuous_domain
method to find the continuous domains of the expression within the specified domain.This was a minimalistic addition with considerable returns (especially for solving periodic inequalties).
Solving trigonometric inequalities.
Since most of the trigonometric inequalities are periodic in nature and have infinite solutions, solving the expression in the entire real domain is a repetitive task and computationally expensive.
In order to simplify the problem, I intend to solve all the inequalities in a positive periodic interval (say
[0, 2*pi)
forsin(x)
). We already have a function to compute the real period of a function :periodicity
.
In case of a non-finitedomain
argument, I intend to use this to restrict the solutions of the problem to a periodic interval.This might not seem the perfect approach but it seems reasonable to handle infinite interval sets for now. We need a new
Set
object :BigUnion
to represent infinite number of interval objects.
New Implementation
I have opened PR#11458 for the same with all the implementation details.
In []: isolve(cos(x) > S(0), x, relational=False)
Out[]: [0, pi/2) U (3*pi/2, 2*pi)
In []: isolve(tan(x) > S(0), x, relational=False)
Out[]: (0, pi/2)
After thoughts
For the past couple of weeks, I haven’t been able to give much time to the project due to my college schedule. I try to make up for the lost time during the weekend and meet the 40 hour weekly deadline.
With the endsem evaluation soon approaching, I expect this PR to get merged and count as a part of my project.


actually
delete
vernadsky
urlhttp//www.blackseanews.net/read/
karlavske
{{convert?kmmi.
shchaslyvtseve
coast.
warbritish
existence.
kazantip
urban-type
role
right
samuel
pashaottoman
essential
uncertain.
????
http//books.google.de/booksidsrr_dmjtac
bulgarians.http//jrs.oxfordjournals.org/content///.full.pdf
few
slavsslavs
interrputed
native
quality
titleautonomous
ministers
{{col-list
trillion


"This is exactly what I had envisioned!!"
"I'm in love with this dApp, but I'm not biased. Seriously."
"The Effect is real, I'm still alive and love using this dApp!"


Hi, you've reached the unofficial home page of Felix Terkhorn. I am software producer living in the USA.
You can find me on other websites below:


jQuery.PrettyTextDiff
A wrapper around Google's diff_match_patch library.
You can run diff on existing text by adding class original
and changed
and add element that compares text. Or you can pass text as a param of function. See example below.
Standard example
Oryginal text
Lorem Ipsum is simply dummy text of the printing and typesetting industry. Lorem Ipsum has been the industry's standard dummy text ever since the 1500s, when an unknown printer took a galley of type and scrambled it to make a type specimen book. It has survived not only centuries, but also the leap into electronic typesetting.
Changed text
Lorem Ipsum is simply typesetting dummy text of the printing and has been the industry's typesetting. Lorem Ipsum has been the industry's standard dummy text ever the 1500s, when an printer took a galley of type and simply it to make a type. It has survived not only five centuries, but survived not also the leap into electronic typesetting.
As a function param
Diff will run after textarea will change. So feel free to play with it to see Diff results.


Q.12.Select the alternative in which the specified components of the key figure (X) are found.
A)
1
B)
2
C)
3
D)
4


Go to the Browse page to find your favorite movies and discover new ones!
Keep track of the movies you want to see, whether it is for the first time or the fifth time!
Keep track of the movies you have seen to be able to brag to your friends about your impressive list!


Vernier Caliper Simulation
Vernier calipers
Vernier calipers can measure internal dimensions (using the
uppermost
jaws in the picture at right), external dimensions using the pictured
lower jaws, and depending on the manufacturer, depth measurements by
the use of a probe that is attached to the movable head and slides
along the centre of the body. This probe is slender and can get into
deep grooves that may prove difficult for other measuring tools.
The vernier scales can be in metric
measurements on the upper and lower part of the scale.
Vernier calipers commonly used in industry provide a precision to a
hundredth of a millimetre (10 micrometres).
A more precise instrument used for the same purpose is the micrometer
.Parts of a vernier caliper:
- Outside jaws: used to measure external diameter or width
of an object (Blue)
- Inside jaws: used to measure internal diameter of an object
- Depth probe: used to measure depths of an object or a hole
( not shown in this model)
- Main scale: gives measurements in mm.
- Vernier gives measurements up to one decimal places in mm
- Retainer: used to block movable part to allow the easy
transferring a measurement ( not shown in this model)
The Vernier calipers model has
- an object (Blue) for the internal jaws to measure width of an
object with slider to control width of the object and simple drag
action to control position of object.
- an object (Green) for external jaws to measure internal diameter
of a cylinder for example with slider to control dimensions of the
cylinder.
- a slider for zero error slider
- checkbox for hint to scaffold the learners attention and point of
focus
- checkbox for answer to show the meaning of reading on the main
scale and the vernier scale with zero error calculations if any.
- drop down menu of the various common vernier scales for sense
making and additional testing out by learners their ideas of how
vernier works.
- fine <> control buttons for learners to manipulate the
model with single incremental precision
- slider control for fast changes in the vernier measurement
- reset button to bring simulaton back to original (default)
setting.
Credits:
The Vernier calipers model was created by created by Fu-Kwun Hwang,
customized by Loo Kang Wee and Wolfgang Christian using the
Easy Java Simulations (EJS) version 4.2 authoring and modeling
tool. An applet version of this model is available on the NTNU
website <
http://www.phy.ntnu.edu.tw/ntnujava/ >.
You can examine and modify this compiled EJS model if you run the
model (double click on the model's jar file), right-click within a
plot, and select "Open EJS Model" from the pop-up menu. You must,
of course, have EJS installed on your computer. Information about
EJS is available at: <http://www.um.es/fem/Ejs/>
and in the OSP comPADRE collection <http://www.compadre.org/OSP/>.


Guard Curtis:
If you are thinking of leaving the village, I give you one warning. Beyond that mountain in the south is a place called the Ruins of Despair. It is an extremely dangerous place so try to stay far away from it. Of course, if you insist on going, I am not going to stop you ...
Ask about the 'Ruins of Despair.'
See the Lord and get the tax rate information.
Quest


My name is Nicholas Bradley Omondi and this here is a representation of several templates combined into one with my own design to show you what I have been able to learn in this past week
As you know my name is Nicholas. I am relatively young and I just finished studying engineering at UoN. I joined Moringa School since I have a passion for programming and with COVID-19 the online presence has increased and it will lead to more opportunities that I would like to take up.
I haven't had much experience in the working field but hopefully with my time in Moringa School I will be able to hit the ground running.
With the first week I believe i can quantify my skills as follows:
CSS:
HTML:
Bootstrap:
A good listener:
Ever since starting my course work at Moringa we have done a few projects and below is a list of some of them with links


Profiles are configuration and application specifications that are deployed into a container. They are organized by versions.
Specifies the version of the profile collection from which deployed profiles are choosen.
Lists all of the profiles available in the selected version. Checking off one or more profiles will deploy them to the new container(s) when they are created.


Teams
Athletics
Audio/Video
Visit Nebraska
Facilities
Tickets
Contact Us
Football
Coaches
Roster
Schedule
Stats
+More
Connect with the
#HUSKERS
Schedule
Results


Chapter 1 - Getting Started
Before you begin, you will need to become a developer partner with Cayan. They will create an account for you and provide you your own credentials and certification packet to get started. Once you have acquired this, you can continue using this library.
There are numerous different components available, but everything starts with a TCayan comopnent. This comopnent carries the credentials to access Cayan's systems, along with other various information, such as the username, company name, and software name. When creating another specific component, such as a TCayanGenius, you will attach this TCayan component to it through its Cayan property to validate using those given credentials.
You will use different components depending on your different support. For example, if you wish to utilize Line Item Display, you will use a TCayanGeniusLineItems component. Otherwise, you won't even need to add the component. Such integration requires a separate certification from Cayan, so if you have never been certified for Line Item Display, then you won't even need to worry about it being in your way.
TCayan Component
The first step of using this library in your application is to drop a TCayan component from the installed components on the Cayan tab in Delphi. This component is the starting point for the rest of the integration.
You will need to populate some of the properties of this component.
- MerchantName (Required) - One of the 3 pieces of credentials provided by Cayan.
- MerchantSiteId (Required) - One of the 3 pieces of credentials provided by Cayan.
- MerchantKey (Required) - One of the 3 pieces of credentials provided by Cayan.
- Dba (Required for Genius) - The name of the company as it will be displayed to the customer.
- SoftwareName (Required for Genius) - The name of the software using the Genius solutions.
- SoftwareVersion (Required for Genius) - The version of the software using the Genius solutions.
- ClerkID (Required) - The username or identification who is using the software.
- StationID (Required) - The identifier for the station within the store / location / site.
- TestMode (Optional) - Triggers the library to run in test mode with fake credentials and transactions.
TCayanGenius Component
If you wish to use Cayan's Genius solution, then drop a TCayanGenius component from the installed components on the Cayan tab in Delphi. This component is used for all communication with a specific Genius CED payment terminal. Multiple terminals will require multiple instances of this component.
You will need to populate some of the properties of this component.
- Cayan (Required) - A previously created TCayan component for authentication.
- Device.DeviceAddress (Required) - The Hostname or IP Address of the Genius CED.
- Device.DevicePort (Required) - The Port Number of the Genius CED (8080 by default).
- Device.DeviceProtocol (Required) - The HTTP protocol which the device requires.
- Device.DeviceTimeout (Required) - The number of seconds before requests are timed out. DEPRECATED
- Device.DeviceVersion (Required) - The highest support level of the device.
- Device.Monitoring (Optional) - Whether or not to continuously check the status of the device.
- ForceDuplicate (Optional) - Whether or not to force duplicate transactions, if detected.
- InvoiceNum (Required) - The invoice number associated with transaction.
- PONumber (Required for Level2) - The purchase order number associated with transaction.
- Amount (Required) - The total dollar amount which transaction is to be for (including tax).
- TaxAmount (Required for Level2) - The dollar amount of tax which transaction is to be for.
- Cardholder (Optional) - Predefined card holder's name.
- CustomerCode (Required for Level2) - The unique identifier of customer's account.
- TransactionID (Required) - The unique identifier of the transaction being done.
- TransactionType (Required) - The type of transaction which is being done.
Additionally, there are some events on this component:
- OnCancel (Required) - Triggered when the POS has sent a cancel command to the device.
- OnDeviceStatus (Optional) - Triggered when the Device.Monitoring property is enabled.
- OnTransactionStaged (Optional) - Triggered when a new transaction has been staged.
- OnTransactionStart (Optional) - Triggered when a transaction has begun on the device.
- OnTransactionResult (Required) - Triggered when the device has finished a transaction.
TCayanGeniusAgreement Component
If you wish to be able to prompt a customer to accept or decline an agreement on the device, then you will need to drop a TCayanGeniusAgreement component in your application. This component allows you to send the request and get a response.
You will need to populate some of the properties of this component.
- Genius (Required) - A previously created TCayanGenius component for authentication.
- Title (Optional) - The title at the top of the device over the agreement.
- AgreementText (Required) - The actual text which is displayed to the customer.
- AcceptLabel (Optional) - The label of the Accept button on the device.
- DeclineLabel (Optional) - The label of the Decline button on the device.
Additionally, there are some events on this component:
- OnAgreement (Required) - Triggered when the customer presses Accept, Decline, or when the device times out.
Chapter 2 - MerchantWare Transactions


Preparation time
less than 30 mins
Cooking time
over 2 hours
Serves
Serves 4
Meltingly tender ox cheeks infused with smoky cardamom, served with cabbage and a richly flavoured spiced sauce.
Equipment and preparation: You will need a small metal tray and a piece of charcoal.
For the smoke, heat the piece of charcoal on an open flame, or with a blow torch, until it starts to smoulder (you can do this on a gas hob). Preheat the oven to 140C/120C Fan/Gas 1.
For the ox cheeks, heat a frying pan with a little oil. Cook the ox cheeks to seal them on all sides. Transfer to a lidded casserole dish. Add the rest of the ox cheek ingredients to the casserole.
Put the charcoal in to a small metal tray. Put the cardamom pods onto the charcoal, followed by the clarified butter. Place the tray on top of the ingredients in the casserole and put the lid on. Leave for 10 minutes to infuse. Remove the charcoal tray and its conents.
Cover the casserole ingredients with boiling water. Put the lid on and cook in the oven 3–4 hours. The ox cheeks should be very tender.
Remove the ox cheeks from the casserole, set aside and keep warm. Discard the vegetables and veal foot. Pass the cooking liquor through a sieve into a clean saucepan.
For the confit cabbage, bring a large saucepan of water to the boil. Add the bicarbonate of soda and a pinch of salt. Add the cabbages and cook for 3 minutes, until tender. Refresh the cabbage in iced water, drain and squeeze out the excess water using a clean tea towel. Finely shred the cabbage.
Melt the butter in a heavy-based pan until foaming. Add the nigella seeds and shallots. Cook until soft, then stir in the cabbage and cook for 5 minutes.
Place the lemon juice, oil, salt and pepper in a small bowl and whisk to combine. Just before serving, dress the red chicory leaves in the dressing and dust with the chat masala.
To serve, divide the cabbage between four shallow bowls. Rest the pieces of ox cheek on top and pour sauce around the sides. Garnish with the dressed chicory, chives and coriander.


Version 1.0
For more information visit www.vipertest.com. The installation and use of this application is subject to your agreement of our terms of service which are listed at www.vipertest.com/terms
You may also acquaint yourself with our privacy policy listed at www.vipertest.com/privacy
All rights reserved
© 2014 HigherOrder


{% extends 'base.html'%} {% import "bootstrap/wtf.html" as wtf %} {% import 'macros.html' as macro%} {% block content%}


Checking the off hand
Since a right click in the air will not generate an event if there is nothing in the off-hand
We should check the off-hand before launching the player into the air
There is now a block in Entities,Player which will allow you to get the stack that is in the off-hand
Modify your code to check the off-hand before launching the player into the air (on a left click)
You can use this code snippet as a guide


{% extends 'base.html' %} {% block content %}
Can you find the answer to the riddle?
Read the story to find clues!


WITNESS LIST
Nominations
February 14, 2019 9:00 AM
Commissioner of Insurance
ON:
Sullivan, Kent Commissioner Texas Department of Insurance (Self), Austin, TX
Commissioner of the Department of Family and Protective Services
ON:
Whitman, Hank Commissioner of the Department of Family and Protective Services (Self;
Texas DFPS), Austin, TX
Executive Commissioner of the Health and Human Services Commission
ON:
Phillips, Courtney Executive Commissioner (Self), TX
Office of State-Federal Relations
FOR:
Hambrick, Thomas Office of State Federal Relations (Self), Washington, DC
Public Utility Commission of Texas
ON:
Botkin, Shelly (Self), TX
D'Andrea, Arthur (Self), Austin, TX
Walker, DeAnn Attorney/Chairman (Self), Austin, TX
Texas Commission on Environmental Quality
FOR:
Lindley, Emily Commissioner (Self; TCEQ), Austin, TX
Texas Military Department
ON:
Norris, Tracy Adjutant General of Texas (Texas Military Department), Austin, TX


|
Background
This interview ran in the premier issue of Lingo Userís
Journal. That issue is no longer available for reprint, but due to
multiple requests, weíre rerunning the interview here.
Editorís note: After the original article ran, I had a number
of comments from people that they liked the interview, but wished I
hadnít interrupted J.T. so much.
In reality, I didnít interrupt him - the phone did. Heíd be
halfway through a reply, and then the phone would ring (again) and his
answer would trail off...
When he returned, we tried to get back on track. I suppose I
could just write "(telephone rings)" all over the place in
the article, but... oops, wait, I hear the phone ringing.
The following is the transcript of an interview with John
Thompson (the "Father of Lingo"). John has been the primary
developer behind Lingo, and the person you can call to thank (or
curse, depending on how your project is going). Remember, this
interview was taken in 1995.
Actually, that's a funny story too. I was interested in software
from a very early age, from junior high school and got in mainly from
the language side, and kind of converged onto the multimedia. I've
always had a very strong interest in art - the visual arts... I was
living in San Francisco, actually in Oakland - the Bay Area - and I
was working for LucasFilms on an editing system. I was staging myself
to move more towards media, using my computer skills to get more into
the media industry, to see how it works. I was interested in not only
the technical aspects, but how the whole production process works, and
how to create tools that make those things acceptable.
Right now movie making, and even video making, is still an
exclusive thing even with the home camera and stuff like that.
This was '85. I went to school in Boston, at MIT.
While I was there, in '83 or '84 I started combining my interest in
the visual arts with computer graphics... I started doing stuff at the
media lab. I focused there on integrating my interest in multimedia
into my computer science degree. I got a minor in visual studies where
I got exposed to film making, graphic design, photography, all that...
It was actually not well known, but there was a lot going on there in
the visual arts in MIT. I did a lot of independent work there,
I built some 3-D graphics systems and an interface to broadcast
equipment, some real-time video processing things, sort of like music
video effects, and from that, that took me more into the video
production end of things, and I was hired from there, that was '84, I
got a job at the DroidWorks, on the EditDroid project, which we were
building a non-linear editing system. This was before digital video,
this was based on laser disks, and so that's how I ended in the Bay
Area working in San Rafael.
From the early days I was interested in the
Macintosh, so I took that opportunity to start looking around for work
on the Macintosh, and I got a Mac Plus and through some people at
DroidWorks, actually the husband of one of the employees there, I got
in touch with Marc [Canter, founder of MacroMind, the original name of
Macromedia]. At that point Macromedia was based in Chicago and they
were making VideoWorks and MusicWorks and GraphicWorks. They've been
around for a while - they were one of the first major applications on
the Macintosh. They were there from, I think they started in '84. I
don't know if you know, but VideoWorks started out on even before the
512K Mac. It was quite a feat that it was able to run.
So I got in touch with Marc through this friend
from DroidWorks and he said he was looking for someone to write the
[video] accelerator - it was in a lot of ways similar to QuickTime.
That was my first work with them.
I evolved from the accelerator to working on the
color paint program in Director. This was still working remotely - I
was in San Francisco and they were in Chicago, and then the company
moved from Chicago to San Francisco about the same time I moved from
San Francisco to New York.
Yeah, well, we were kind of hop-scotching! Anyway,
during the transition, the focus of the company wasn't really clear.
Pretty much one of my interests was languages; I've been working on
languages since high school. In high school I had written a BASIC
interpreter and in college I wrote about three different versions of a
Lisp environment, one that was on a PDP-12.
No, it was just my personal interest. I wrote it
for a, actually it was a pre-digital computer. It was one of these
decimal computers that was used for business. It was like a 1950 or
1960 model IBM. A 1620 I think it was. It was on cards!
Yeah - no storage.
Well, no, actually I integrated Lingo into Director
2.0 on my own initiative. I wanted to see some of my work on
interactive languages that I had been using for interactive art in a
commercial product.
Yeah, well I was still a contractor, or a
consultant, but most of my time was spent with MacroMind products at
that point. The company's focus at that point was 3-D Works. It was
kind of an unsupervised project - what they had at that point was
VideoWorks Interactive, which was a central, BASIC-like language
hooked on to the animation engine and that was used for the Guided
Tour on the Macintosh.
And that was where Lingo started - it was a
replacement for that BASIC language. (We were using a BASIC language)
that I think was copied out of an article in Dr. Dobbs, so it was a
very rudimentary implementation of a BASIC interpreter - you had
single character variable names, the variables were typed by their
names...
Yeah. So Lingo was a replacement for that. It
started out just incrementally, because I was doing interactive stuff
myself and I wanted to use Director to do it, so first I plugged in
the xobject stuff, which was some code I had set up to control video
disk and some other stuff that I was using in my interactive art. So,
xobjects went in from day one, and then I started putting in more of
the traditional features you find in a language: recursion, untyped
variables, all that kind of stuff.
Actually, from its very first incarnation it was
object-oriented. Back at that point - this was '87 - this was when C++
and Objective C were making headway and I've done a lot of research on
Smalltalk and the Lisp environments.
Yeah, I had used Smalltalk in school and on my own.
It's a great language, it's very elegant, has a long history of
development. It has some problems, but it's actually far ahead of the
implementations of interactive languages now. If you compare it to,
say, ScriptX, Smalltalk is lightyears ahead in terms of performance
and reliability.
It's making a headway now for people who want to
migrate to the object-oriented technology and they don't have an
investment in C.

Yeah, and if you don't have that commitment, like
if you're starting with COBOL, and you decide we're going to retrain
everybody anyway, it's actually very cost-effective to go to
Smalltalk. I think there's a Xerox PARC implementation that's been
around for a long time and it's on all the major platforms. I know
some people that are doing MIS work, and one of their strengths is
that they do have skills in Smalltalk and can deploy stuff on all
these platforms very quickly.
It was written, originally, in Pascal, but now it's
in C. There were two major rewrites... there was a first
implementation of Lingo, which shipped out in Director 2.0, and that
was a straight interpretive language; there was no pre-processing on
the text or anything. Then there was a total rewrite to be a compiled
P-code based language and that went out first in the Director Player
for Windows, 3.1, that was...
Yeah. First in Director Player for Windows and then
in Director 4. That was a pretty significant rewrite, because it was
rewritten not only for performance, to be compiled, but it was also
written to be portable. That's like the first chunk of Director that's
been portable and it's been used in 3DO, and 3DO player...
Yeah, so we're still reaping the benefits from
that.
I'm not sure what he said, but the...
Yeah, there's always been talk of that. We haven't
set a firm schedule. It's something that, in terms of vision, that's
been in place. In fact, the xobject stuff, originally, was made so
that they could fit into MediaMaker and into 3D Works, and some of
that stuff's been used in other products already, from the early days.
I see Lingo as more of an interpretive environment,
or high-performance instant language, like Smalltalk or Lisp, and
there the direction is not so much to give you more access to the
lower level stuff like pointers and blocks of memory, but to provide
high-level constructs that are more powerful and take less training to
manage.
Yeah, I think what you're talking about is a more
open architecture.
It's definitely going to be a scripting language. I
think there's a couple of features people want that would get
integrated into it. One of the things would be better, more open,
architecture, so you can do more things from an xobject, like being
able access the lists from an xobject.
Those type of things are definitely going to be,
those are on the near horizon. I can't say when; that I put in a class
of opening it up. The other type of features are other high-level
language constructs... thing's you'd see in SmallTalk and ScriptX and
Lisp: high-level constructs like media data types, and threads, being
able to compile it down so that the parts of the language that you
don't use are not there...
Yeah, more optimization. That's another area.
Improvements to performance, like faster execution, and I'd like to
see a smaller footprint. I want to improve the ease of use: make it
more regular and consistent and add things like browsers and debuggers
and just a more open architecture overall.
Yes, that is a nice part. I call that
"scalability", where you can grow into the language.
Right, I've got a book I've been doing with Hayden
Press, called the Macromedia Director Lingo Workshop. It's targeted
toward beginners & intermediates. It's specifically for the
non-programmer's and introduces you to the basic elements. Near the
end it introduces you to Object Oriented Programming, showing you the
benefits of OOP.
It's got 14 chapters. It starts off introducing you
to the Goto command and works from there. It comes with a CD with some
500 movies as samples.
It should be out in July.
Well, I've also been teaching part time for the
last 6 years at NYU Tisch School of the arts in the Interactive
Telecommunications Program. It is one of the few graduate programs in
new media. The program is run by Ms. Red Burns, very dynamic and
forward thinking person. And, of course, I'll still be working with
Director.
The challenge with Director is to help people see
the new potential with multimedia. Take Dazzeloids [by Rodney
Greenblat]. Now there's a tremendous product with actually very little
in the way of Lingo - some goto's, and that's about it. But
artistically, it's great.
Yeah, it really is.
Thank you.
top |


Name: should be unique and reflect the data that is being processed (Cohort, type, subtype, year of study, year of vaccination). This is what shows up in module dropdowns and ImmuneSpaceR connections so keep it short.
Comments: If the Name isn't descriptive enough, add details here. Or if a specific normalization was used, indicate it here.
Feature Annotation Set: If you cannot find the one you are looking for, add it here.
Pipeline: No choice.


$C194/49556: Prepare error msg after executing command Jump from $C99E, $C9A4, $CAC9, $CB6F, $CC18, $CCFB, $CD16, $CD5C, $CD70, $CD94, $CDA0, $CDB7, $CDCF, $D00B, $D7F0, $D99D, $DAE6, $DAFC, $E272, $EDB0, $EEB4: C194: A9 00 LDA #$00 C196: 8D F9 02 STA $02F9 Jump from $DA06: C199: AD 6C 02 LDA $026C ; flag set? C19C: D0 2A BNE $C1C8 ; yes, then set error message C19E: A0 00 LDY #$00 C1A0: 98 TYA ; error number 0 C1A1: 84 80 STY $80 ; track number 0 Jump from $C87A: C1A3: 84 81 STY $81 ; sector number 0 C1A5: 84 A3 STY $A3 C1A7: 20 C7 E6 JSR $E6C7 ; prepare 'ok' message C1AA: 20 23 C1 JSR $C123 ; erase error flag Jump from $DAE9, $DAFF: C1AD: A5 7F LDA $7F ; drive number C1AF: 8D 8E 02 STA $028E ; save as last drive number C1B2: AA TAX C1B3: A9 00 LDA #$00 C1B5: 95 FF STA $FF,X C1B7: 20 BD C1 JSR $C1BD ; erase input buffer C1BA: 4C DA D4 JMP $D4DA ; close internal channel Previous Page / Next Page


{% extends "yacon/examples/base.html" %} {% load yacon_tags %} {% block body %}
Must be logged in for this to work.


timeseRies
version of 2019-02-26
Preliminary remarks
This is a web complement to MATH 342 (Time Series), a third year bachelor course offered at EPFL.
We shall use the R programming language througout the course (as it is free and it is used in other statistics courses at EPFL). Visit the R-project website to download the program. The most popular graphical cross-platform front-end is RStudio Desktop.
R is an object-oriented interpreted language. It differs from usual programming languages in that it is designed for interactive analyses.
Since R is not a conventional programming language, my teaching approach will be learning-by-doing. The benefit of using Rmarkdown is that you see the output directly and you can also copy the code.


I have been working in tech for almost a decade. I love playing with new technologies, I love to learn and I am a strong believer in free and open source technologies. I also love working in teams to build awesome things together.
I live in Wellington, New Zealand, which is a pretty awesome place. I am well travelled though and have also lived in London and Berlin and I am originally from sunny Northern Ireland.
I love music, video games and football. I live with my awesome wife and my two slightly eccentric cats.
I have played with loads of tools over the years. Some examples include the following.
Node, React, Redux, Passport, Express, Heroku, test driven development, Postgres, MySQL, PHP, Ruby, Python, Git, Red Hat, Ubuntu, Suse, Solaris, Windows Server, Puppet, Foreman, FreeIPA, Grafana, Jira, Confluence, Bitbucket, Nagios....
I like to dabble.


We’re a technology company called Canary. We’re dedicated to preventing workplace harassment and building a safer world for us all.
Filing a claim of sexual harassment can be overwhelming. What should you say? Who should you tell? We are here to help!
This tool will help you write down your experiences, and help you understand your options. It is completely anonymous, and we never save any of your information.
Each company has their own policies for sexual harassment. These policies should be clearly elaborated in an employee handbook. If you don’t know your employer’s policies or how to raise a concern within your organisation, we recommend you first check the handbook. Then, you can ask your HR representative to explain the process to you.
If you do know the policies and would like to submit a formal grievance letter, Citizens Advice has an online web form to help you build your letter.
If you can’t resolve your problem by speaking to your employer, you can:


Tom Hanks just found out he's related to Mister Rogers
by KNOE(CNN) - Talk about getting into character!
Actor Tom Hanks just found out Sunday that he's related to Fred Rogers, the man who played 'Mister Rogers' on the children's TV show.
The two are sixth cousins, Ancestry.com discovered.
Hanks is playing 'Mister Rogers' in the upcoming film, "A Beautiful Day in the Neighborhood."
Hanks says he didn't know they were related when he took the role.
The actors share a fifth great grandfather who immigrated from Germany to America in the 18th century.
"It's a Beautiful Day in the Neighborhood," premiers November 22nd.


Llama - a camel like social animal found in South America have widely domesticated since pre Columbus era mainly used for transportation. They are around 1.7m to 1.8m tall at the top of the head and weight around 300-400 lbs. Unlike camels they do not have hump although they are highly thirst tolerant enabling them to walk 5-8 miles while carrying loads euivalent upto 30% of their body weight. Also, can reach speeds up to 35mph.
Scientific name (species) of llama is 'Lama glama'. Their average life span is 15-20 years. Due to their extremly long and complex intestine they can survive on much less water water, vitamins and electrolytes gets reabsorbed while food waste is passing through. Their three compartment stomach allows them to comsume low quality high cellulose food such as grass
As they are mammals, they breed through mating. While females are mature to breed at 18 -24 months old, males get mature to breed at an age of around 3 years. The gestation period is approximately 350 days. Typically, only one cria (llama baby) is born at a time.
Llamas are very well-socialized among themselve and often with human as well due to which they can be well trained. They usually stay in families and trigger high pitch alarms to warn other members in case of danger. However, they may spit for the quest of rank. In case of mistreat, they may spit human as well although it is quite rare.
Due to the ease of training and litte care, they are very useful. They are often used as pack animals. In North America, they have been used as guard animals. Also, they are good source of fibre due to their fine undercoat, which can be used for handicrafts and garments of different colors. Due to lack of odor, their excreta is used as eco-friendly fertilizers.
So llamas are smart, friendly, cooperative, fast, alert, and durable. With all these qualifications llama became the national symbol of Peru. But that's it? Are they meant to be just guards or do they have larger scope? Yes, they can be your fighter, savior in case of war.
"You players, you Villagers. Your war is destroying our world!" - Steve the Llama
Steve the llama aka The Mighty Llama Spirit is a fictional charactor is know for such traits.
Currently, I am a master's student at NYU Courant. I have full time experience of developing web-applications that are scalable, responsive, localized, support accessibility (WCAG 2.0) and are used by thousands of people world wide every day. I find this field (especially the front-end) as quite challenging as it has to deal with several changes such as browser updates, device changes, cross-platform and network speed. Therefore, an error-free site has to be tolerant to these.
This site is structured into two main components - one for information related to llama that is the main purpose of the site, another for the details of the author and the technical details of this site.
Since it is a very light weight site, it is a single page application. While maintaining a basic layout without using too many fancy CSS stuffs, different skills have been demonstrated. Visitor can get the information without scroll and it is responsive to different screen sizes.
Different types of information about llama have been segregated so that it can helpful for different section of visitors. Whether someone just wants to know about what is llama or someone is searching for some fun facts, this site serves everyone.
Apart from basic HTML, CSS and JavaScript, AngularJs has been used for switching contents based upon menu items click. Since AngularJs provides two way binding, it eases the effort of controlling DOM elements through JavaScript.
In order to make it responsive, Bootstrap has been used. Since there isn't too much css involved therefore no CSS pre-processor has been used.


Equivalent to clicking the Define button in the Style dialog box, which appears when you click the Style command on the Format menu. Creates and changes cell styles. There are seven syntax forms of this function. Use syntax 1 of DEFINE.STYLE to define styles based on the format of the active cell. To create a style by specifying number, font, and other formats, use syntaxes 2 through 7 of DEFINE.STYLE.
Syntax 1
Syntaxes 2-7
Return to index
Equivalent to clicking the Define button in the Style dialog box, which appears when you click the Style command on the Format menu. Creates and changes cell styles. There are seven syntax forms of this function. Use syntax 1 of DEFINE.STYLE to define styles based on the format of the active cell. To create a style by specifying number, font, and other formats, use syntaxes 2 through 7 of DEFINE.STYLE.
Syntax
DEFINE.STYLE(style_text, number, font, alignment, border, pattern, protection)
DEFINE.STYLE?(style_text, number, font, alignment, border, pattern, protection)
Style_text is the name, as text, that you want to assign to the style.
The following arguments are logical values corresponding to check boxes in the Style dialog box. If an argument is TRUE, Microsoft Excel selects the check box and uses the corresponding format of the active cell in the style; if FALSE, Microsoft Excel clears the check box and omits formatting descriptions for that attribute. If style_text is omitted and all selected cells have identical formatting, the default is TRUE; if cells have different formatting, the default is FALSE.
Number corresponds to the Number check box.
Font corresponds to the Font check box.
Alignment corresponds to the Alignment check box.
Border corresponds to the Border check box.
Pattern corresponds to the Pattern check box.
Protection corresponds to the Protection check box.
Related Functions
DEFINE.STYLE Syntaxes 2-7
APPLY.STYLE Applies a style to the selection
DELETE.STYLE Deletes a cell style
MERGE.STYLES Imports styles from another workbook into the active workbook
Return to index
Equivalent to clicking the Define button in the Style dialog box, which appears when you click the Style command on the Format menu. Creates and changes cell styles. Use one of the following syntax forms of DEFINE.STYLE to select cell formats for a new style or to alter the formats of an existing style. Use syntax 1 of DEFINE.STYLE to define styles based on the format of the active cell.
Syntax 2
Number format, using the arguments from the FORMAT.NUMBER function
DEFINE.STYLE(style_text, attribute_num, format_text)
Syntax 3
Font format, using the arguments from the FORMAT.FONT and FONT.PROPERTIES functions
DEFINE.STYLE(style_text, attribute_num, name_text, size_num, bold, italic, underline, strike, color, outline, shadow, superscript, subscript)
Syntax 4
Alignment, using the arguments from the ALIGNMENT function
DEFINE.STYLE(style_text, attribute_num, horiz_align, wrap, vert_align, orientation)
Syntax 5
Border, using the arguments from the BORDER function
DEFINE.STYLE(style_text, attribute_num, left, right, top, bottom, left_color, right_color, top_color, bottom_color)
Syntax 6
Pattern, using the arguments from the cell form of the PATTERNS function
DEFINE.STYLE(style_text, attribute_num, apattern, afore, aback)
Syntax 7
Cell protection, using the arguments from the CELL.PROTECTION function
DEFINE.STYLE(style_text, attribute_num, locked, hidden)
Style_text is the name, as text, that you want to assign to the style.
Attribute_num is a number from 2 to 7 that specifies which attribute of the style, such as its font, alignment, or number format, you want to designate with this function.
| Attribute_num | Specifies |
| 2 | Number format |
| 3 | Font format |
| 4 | Alignment |
| 5 | Border |
| 6 | Pattern |
| 7 | Cell protection |
Remarks
The remaining arguments are different for each form and are identical to arguments in the corresponding function. For example, form 2 of DEFINE.STYLE defines the number format of a style and corresponds to the FORMAT.NUMBER function. The exception is form 5, which does not include every argument for BORDER. For details on the values you can use for these arguments, see the description under the corresponding function.
If you define a style using one of these forms, then any attributes you don't explicitly define are not changed.
Related Functions
DEFINE.STYLE Syntax 1
ALIGNMENT Aligns or wraps text in cells
APPLY.STYLE Applies a style to the selection
BORDER Adds a border to the selected cell or object
CELL.PROTECTION Allows you to control cell protection and display
DELETE.STYLE Deletes a cell style
FONT.PROPERTIES Applies a font to the selection
FORMAT.NUMBER Formats numbers, dates, and times in the selected cells
MERGE.STYLES Imports styles from another workbook into the active workbook
PATTERNS Changes the appearance of the selected object
Return to index


TIFF Documentation
A copy of the 6.0 specification is available by public ftp at
This is a PostScript version of the final 6.0 specification compressed
with the standard UNIX compress(1) program.
An uncompressed PostScript file is also available as TIFF6.ps in
the same directory.
Adobe provides the 6.0 spec online in
Acrobat format (PDF); this can be found at
TIFF Technical Notes can be retrieved from
Last updated: $Date: 1999/10/05 01:01:23 $


API (List of modules and functions)¶
Code is divided into the following modules:
Gridder¶
calculate_gridcell_areas |
Calculates the area of each of the grid-cells in the domain (in km^2) |
grid_merger |
Combines several gridded files into one |
gridder |
Counts “pings” inside a grid-cell and computes “Ship minutes per km2” |
mergedgrid_to_shp |
Converts a gridded file into a shapefile |
grid_to_esriascii |
Writes ESRI ASCII file from gridded data |
gridder.getWKT_PRJ |
Downloads and returns geospatial parameters given an epsg code |
gridder.gridder_pingsPerCell |
Counts “pings” inside a gridcell and computes “No. |
Mapper¶
make_basemap |
Makes a basemap |
map_density |
Plots a map using a gridded (or merged) file |
map_dots |
Creates a map of “pings” rather than gridded density |
map_dots_one_ship |
Creates a map of “pings” (i.e. |
save_basemap |
Saves basemap (and correspoding info.grid) to a pickle file |
mapper.load_my_cmap |
Creates and loads custom colormap |
mapper.define_path_to_map |
Figures out where is the .basemap and .grid files |
mapper.make_legend_text |
Makes text for legend in left block of map |
Info_Object¶
attrs_to_info |
Appends attributes to info object |
data_to_info |
Reads metadata from data source (i.e. |
info |
info class makes and ‘info object’ which contains all the metadata needed to run a project. |
info_to_attrs |
Extracts attibutes from info object |
load_info |
Loads “info” file |
make_info_from_GridData |
Makes info object and populates its metadata from .basemap and .grid files |
info_object.auto_update |
Updates some metadata in info file |
Converters¶
bulk_convert_to_nc |
Converts ALL raw files in a directory into “Standard” .nc ship_mapper files |
bulk_update_attributes |
Updates attributes in ALL files in a directory |
convert_to_nc |
Import appropiate converter, which is a file in folder “converters” within this module, or a customade file in the “path” folder |
Included converter files:
Utils¶
align_with_grid |
Finds which gridcell contains a given lat/lon point |
checkDir |
Check if directory exists. |
degrees_to_meters |
Converts degrees to meters |
distance |
Estimates distance between 2 points on Earth. |
elapsed_days |
Estimates elapsed days |
estimate_velocity |
Estimates velocity (in knots) given seconds elapsed to cover a distance (in meters) |
get_all_files |
Returns all files within a directory |
get_filename_from_fullpath |
Returns the filename given a fullpath to a file |
get_path_from_fullpath |
Returns the path to a file given a fullpath to the file |
interp2d |
Interpolated between 2 points |
make_mydirs |
Makes directories needed for project |
spatial_filter |
Returns only the “pings” within a defined box. |
stop |
Stop |
write_info2data |
Writes metadata from info object to the attibutes section in the data |
Oracle¶
oracle.download_vms |
Downloads VMS data from oracle database |
oracle.filter_by_gear |
Filters data by gear type |


Upgrade Firmware
| Partition Name | Partition Size | App Version | App Valid | App Running | App Set Boot | App Upload |
|---|
| Partition Name | Partition Size | Data Type | Erase |
|---|
Loading...
| Partition Name | Partition Size | App Version | App Valid | App Running | App Set Boot | App Upload |
|---|
| Partition Name | Partition Size | Data Type | Erase |
|---|
Loading...