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Man killed by roller coaster at Berlin Christmas market
A busy Christmas market in the German capital has been cleared out after a man was crushed by a roller coaster. Police are investigating the cause of the accident.
A man was killed by a roller coaster at a Christmas market in Berlin on Saturday night, the city's fire department said. The cause of the accident is currently unknown.
Fire department spokesman Jens-Peter Wilke said the man was hit by the roller coaster and crushed underneath.
Firefighters responded to the incident shortly after 7 p.m., but attempts to revive the man on site were unsuccessful. A family that had been on the ride received psychological treatment. Berlin police said they did not suspect foul play.
According to the fire department, the man was most likely a ride attendant.
The Christmas market, on a large parking lot on Landesburger Allee in Berlin's northeast, was closed after the incident. It had just opened on Friday.
wmr/aw (dpa)


This remote island has, for convenience, been included in French Polynesia, but since 2007 has been designated as an Overseas possession of France.
Clipperton is an uninhabited atoll, some 700 miles (1125 km) off the Mexican coast.
The lagoon of this atoll has no pass, but the few yachts which stop there can shelter in the lee of the reef. Landing through the surf is sometimes difficult but the diving on the surrounding reef makes up for it.
Position 10°18′N, 109°13′W.


Transaction¶
-
class
transaction.
Transaction
[source]¶ Represents a transaction in GnuCash.
-
associated_uri
¶ URI associated with the transaction.
Returns: URI associated with the transaction Return type: str
-
cleared
¶ Checks if all splits in the transaction are cleared.
Returns: Boolean indicating if all splits in the transaction are cleared. Return type: bool
-
mark_transaction_cleared
() → None[source]¶ Marks all splits in the transaction as cleared (reconciled_state = ‘c’).
-
reversed_by
¶ GUID of the transaction that reverses this transaction.
Returns: Transaction GUID Return type: str
-
void_reason
¶ Reason that the transaction was voided.
Returns: Reason that the transaction was voided Return type: str
-
-
class
transaction.
Split
(account: Optional[gnewcash.account.Account], amount: Optional[decimal.Decimal], reconciled_state: str = 'n')[source]¶ Represents a split in GnuCash.
-
class
transaction.
TransactionManager
[source]¶ Class used to add/remove transactions, maintaining a chronological order based on transaction posted date.
-
add
(new_transaction: transaction.Transaction) → None[source]¶ Adds a transaction to the transaction manager.
Parameters: new_transaction (Transaction) – Transaction to add
-
delete
(transaction: transaction.Transaction) → None[source]¶ Removes a transaction from the transaction manager.
Parameters: transaction (Transaction) – Transaction to remove
-
get_account_ending_balance
(account: gnewcash.account.Account) → decimal.Decimal[source]¶ Retrieves the ending balance for the provided account given the list of transactions in the manager.
Parameters: account (Account) – Account to get the ending balance for Returns: Account starting balance Return type: decimal.Decimal
-
get_account_starting_balance
(account: gnewcash.account.Account) → decimal.Decimal[source]¶ Retrieves the starting balance for the current account, given the list of transactions.
Parameters: account (Account) – Account to get starting balance of. Returns: First transaction amount if the account has transactions, otherwise 0. Return type: decimal.Decimal
-
get_balance_at_date
(account: gnewcash.account.Account, date: Optional[datetime.datetime] = None) → decimal.Decimal[source]¶ Retrieves the account balance for the current account at a certain date, given the list of transactions.
If the provided date is None, it will retrieve the ending balance.
Parameters: - account (Account) – Account to get the balance of
- date (datetime.datetime) – Last date to consider when determining the account balance.
Returns: Account balance at specified date (or ending balance) or 0, if no applicable transactions were found.
Return type:
-
get_transactions
(account: Optional[gnewcash.account.Account] = None) → Iterator[transaction.Transaction][source]¶ Generator function that gets transactions based on a from account and/or to account for the transaction.
Parameters: account (Account) – Account to retrieve transactions for (default None, all transactions) Returns: Generator that produces transactions based on the given from account and/or to account Return type: Iterator[Transaction]
-
minimum_balance_past_date
(account: gnewcash.account.Account, date: datetime.datetime) → Tuple[Optional[decimal.Decimal], Optional[datetime.datetime]][source]¶ Gets the minimum balance for the account after a certain date, given the list of transactions.
Parameters: - account (Account) – Account to get the minimum balance information of
- date (datetime.datetime) – datetime object representing the date you want to find the minimum balance for.
Returns: Tuple containing the minimum balance (element 0) and the date it’s at that balance (element 1)
Return type:
-
-
class
transaction.
ScheduledTransaction
[source]¶ Class that represents a scheduled transaction in Gnucash.
-
class
transaction.
SimpleTransaction
[source]¶ Class used to simplify creating and manipulating Transactions that only have 2 splits.
-
amount
¶ Dollar amount for funds transferred.
Returns: Dollar amount for funds transferred. Return type: decimal.Decimal
-
from_account
¶ Account which the transaction transfers funds from.
Returns: Account which the transaction transfers funds from. Return type: Account
-


GitLab is a platform for the whole DevOps lifecycle. GitLab is the world's largest remote company, with over 1,300 team members in 68 countries and regions. GitLab works with thousands of developers and millions of users to deliver new innovations. Over 100,000 organizations trust GitLab to deliver great software, faster.


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Because security is always GoldFynch's top priority.
It's your data. We don't access it, copy it, modify it, or share it. We keep it 100% secure. You can download it any time. If you ever leave us, we will remove all copies.
Maintaining the security and confidentiality of your project-related data is our top priority.
GoldFynch is trusted by thousands of companies throughout 147 countries worldwide to manage their projects in the cloud. We have never encountered a security breach or loss of customer files. We pursue the highest professional standards to ensure your data is always safe.
Secure access over HTTPS (SSL) is provided with all GoldFynch domains. Only certain members of the GoldFynch team have direct access to the live database and all access is logged. Our data-centers have passed the SSAE16 audit. For information about security on our Enterprise Plan please contact us.
All GoldFynch accounts are password protected (pretty standard). We also provide an option to require complex passwords. All user passwords are stored in the database only after being passed through a one-way hash-and-salt technique (a standard practice for high security).
Each and every file, document, image, task, milestone, and byte of information you store with us is owned by you. We won't copy, share, or modify your data. We will never even access your data without your consent. If you ever delete your account, we will delete all your data from our servers after a period of 30 days. You can download a full copy of your database once each day. Our "file backup tool" allows you to keep a copy of all files.
Because security is always GoldFynch's top priority.


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alot of coins start with a high trading price but that was crazy
ch6ris21-Jan-19 11:37 AM
Yeah zcash did that, 20btc or something close. btc was only worth around $800 at that time though. from memory don't trust my numbers.(edited)
slow start and fomo, did that. then it slowly dropped to $30, When i bought a boat load. then it wen't to $600 and I didn't sell and back to where I started pretty much.
At least zcash is legit with a real team/company/money.
CryptoNinjaa21-Jan-19 11:41 AM
Yeah for sure. There aint many legit teams about. plenty of fluff projects around which are all falling apart now
1
ch6ris21-Jan-19 11:42 AM
I kept saying I'll wait I little longer, I'll wait I little longer, then when I got there they told me he had already left.
ComputerGenie 👴👴👴21-Jan-19 11:43 AM
At least zcash is legit with a real team/company/money.
$77025 USD per day of income definitely counts as "legit money"
1
CryptoNinjaa21-Jan-19 11:43 AM
I think evryone has been there at some point. woulda shoulda coulda
ch6ris21-Jan-19 11:44 AM
Was waiting for you to chime in Genie!
CryptoNinjaa21-Jan-19 11:44 AM
At least its transparent CG everyone who mines know that
ComputerGenie 👴👴👴21-Jan-19 11:44 AM
You give miners too much credit
CryptoNinjaa21-Jan-19 11:44 AM
lol
ComputerGenie 👴👴👴21-Jan-19 11:45 AM
You'd be amazed at how many people using the NH mining app actually believe they are "mining Bitcoin"
CryptoNinjaa21-Jan-19 11:46 AM
you mean im getting paid in btc but not mining btc!!!
2
ch6ris21-Jan-19 11:48 AM
This space is still for those with above average technical skills. You'd be amazed at how many people can't install an operating system.
ComputerGenie 👴👴👴21-Jan-19 11:48 AM
you mean im getting paid in btc but not mining btc!!!
Nope, and using BitPay isn't vendors "accepting crypto-currency" either
You'd be amazed at how many people can't install an operating system.

CryptoNinjaa21-Jan-19 11:49 AM
So you mean i paid for btc in £ to then purchase some nice bitcoin socks in btc for them to get £. Im really pissed
ComputerGenie 👴👴👴21-Jan-19 11:49 AM
I live in a county of 15k people and I made a living (for nearly a decade) doing just that
ch6ris21-Jan-19 11:50 AM
Cool story, how did you get started. I would love to do something similar.
ComputerGenie 👴👴👴21-Jan-19 11:50 AM
people, literally, paid me hundreds to drive 2 hrs and install the new Winduhs they bought at Walmart
CryptoNinjaa21-Jan-19 11:51 AM
Madness but i can believe it
ComputerGenie 👴👴👴21-Jan-19 11:51 AM
I started with just a few neighbors, then took out a few paper ads and a radio spot here and there
1
ch6ris21-Jan-19 11:51 AM
oh yeah they came on those holographic cd's.  I thought that was a u.s only company. Don't have any where I am.
ohh no multinational.
ComputerGenie 👴👴👴21-Jan-19 11:55 AM
Walmart is 2 counties over (almost an hr), but it's the only "big" store around
ch6ris21-Jan-19 11:56 AM
ahh following. country lines are foreign to me because we don't have any. only ocean.
ComputerGenie 👴👴👴21-Jan-19 11:57 AM
no "box stores" nearby, but we've got 900 gajillion gas stations
ch6ris21-Jan-19 11:58 AM
If I tried hard enough I could probably narrow down what country your in but I can't be bothered.
ComputerGenie 👴👴👴21-Jan-19 11:58 AM
country lines are foreign to me
here we have a "hierarchy" of govt:
local town/city >> county >> state >> federal(edited)
ch6ris21-Jan-19 12:00 PM
Yeah it's probably about the same here. Councils run the town's/suburbs/city's. state government then federal.(edited)
ComputerGenie 👴👴👴21-Jan-19 12:01 PM
we added counties between city and state because we like giving more money to govt
ch6ris21-Jan-19 12:02 PM
Who doesn't. Who else will maintain those roads.
ComputerGenie 👴👴👴21-Jan-19 12:02 PM
roads? what are those?
1
ch6ris21-Jan-19 12:04 PM
Least you have internet access. I'm sure your government helped fund that.
1
The latest from the government here is half arse attempt of fiber.(edited)
Fiber to the x
ComputerGenie 👴👴👴21-Jan-19 12:07 PM
I have internet because some random company decided to buy as many small phone companies as they could and then they got bought by some other random company
meanwhile, the quality of service is better (as is the speed) in the middle of the Australian plains than it is here(edited)
I have the 3rd largest ISP in the US and, literally, the same DSL lines we got a decade ago
ch6ris21-Jan-19 12:09 PM
I am in the bush and I gotta say shit has indeed improved.
That's a bit harsh. Guess you need another step in your local hierarchy, More money.
ComputerGenie 👴👴👴21-Jan-19 12:11 PM
LOL
I called up about getting bonded 20M DSL and it took them 2 weeks of looking into it and event then they didn't comprehend that it's 2 service lines
>How much is the wire going to cost me?
>>There's no need to run a new wire
>You're going to give me a bonded setup on the existing 2 wire line?
>>Yes
blackjok3r21-Jan-19 12:14 PM
Yeah internet here on NBN is great.... I'm 500-800m from the excahnge though... Even DSL wasnt bad.
Bought my house mostly because it was close to the main exchange
ch6ris21-Jan-19 12:14 PM
That's terrible genie, There actually removing alot of the copper here.
blackjok3r21-Jan-19 12:14 PM
got afew streets up the hill and net is poor as hell
ch6ris21-Jan-19 12:15 PM
Indeed, Its a bit messy. I'm on wireless nbn and it's faster than my family's fibre to the curb.
1
ComputerGenie 👴👴👴21-Jan-19 12:16 PM
The sad thing is that I'm not exaggerating; by "2 wire" I literally mean that there are only 2 wires running from the trunk junction to our buildings (our system is that old)
We don't even have the 4 wire that was "standard" by the time I was born (and I'm in my 40s)(edited)
blackjok3r21-Jan-19 12:18 PM
wow... I think I have 4 wires... but they are not connected to anything. Still using DSL, but its very short range, get 100mbit but I'm only on 50 atm. as 50 gives 25mbit upload it seemed fine. Only been a few times I've wanted to get 100mbit... catn see it worth the extra cost atm.
ch6ris21-Jan-19 12:19 PM
Where ever you are Geine, get out. backwards town going no where.
blackjok3r21-Jan-19 12:19 PM
There is still no option to use another provider... thats the real issue IMO.
ComputerGenie 👴👴👴21-Jan-19 12:19 PM
100M here would cost 100s of millions because everything would have to be new
blackjok3r21-Jan-19 12:19 PM
I think the austalian governement spent liek 40 billion on the current internet here(edited)
ComputerGenie 👴👴👴21-Jan-19 12:20 PM
backwards town going no where
The cost of living in the middle of nowhere
blackjok3r21-Jan-19 12:20 PM
and its still not very good... governemtn owns the entire internet pretty much also that is very bad.
1
ch6ris21-Jan-19 12:20 PM
and it's nothing compared to a country like Singapore for example (Half arse save money attempt)
ComputerGenie 👴👴👴21-Jan-19 12:20 PM
The US govt has always owned the internet
ch6ris21-Jan-19 12:20 PM
They still do indeed.
And could theoretically shut it down.
blackjok3r21-Jan-19 12:22 PM
I think not long ago 1 DNS server went down in US, and multiple cities had no internet... I thaught it was designed from the bottom up to prevent that from happening..
ComputerGenie 👴👴👴21-Jan-19 12:22 PM
in other unrelated news, @blackjok3r, I've almost nailed down the js lib for using P2PK in coinbase
blackjok3r21-Jan-19 12:23 PM
nice
What about pay to multisig
ComputerGenie 👴👴👴21-Jan-19 12:24 PM
It still has something screwy where it makes KMD chain run a check that it should only run on assetchains, but I'm getting close for P2PK
I'm too lazy and uncaring for multisig atm
Contribute to DeckerSU/bitcore-lib-komodo development by creating an account on GitHub.
wait Idont think that is actally it
ComputerGenie 👴👴👴21-Jan-19 12:28 PM
I screwed up an if in the lib, somewhere, I guess; so, it produces something just on the edge of right enough to work, but wrong enough to send komodod down the wrong check path


--- title: Car-free Sunday excerpt: Today, on a sunny Sunday, Brussels feels like a perfect place to be in. There are just a few cars around as only public transport, taxis and emergency vehicles are allowed to enter the city streets. date: '2008-09-21 18:27:39 +0200' date_gmt: '2008-09-21 16:27:39 +0200' categories: - Brussels - General tags: - Brussels - cars ---
Today, on a sunny Sunday, Brussels feels like a perfect place to be in. There are just a few cars around as only public transport, taxis and emergency vehicles are allowed to enter the city streets. Cyclists, skateboarders, rollerskaters, pedestrians, and even horse-drawn carriages take to the streets. I just wish it would be a bit like this tomorrow too; but I guess I'm asking for too much.
Now, it's not easy to arrange a car-free day in a city where driving is vigorously encouraged and where people still take their car to get bread around the corner, even if the car is parked further away (USE-IT)
.
A car-free day is a good idea, so why not expand it? After seeing how much people enjoy this event every year, it's hard to comprehend why many people are so addicted to cars. It's a learned behaviour, of course. Organising a day like this is a good step, but it's not enough.
Belgium is also a country where in 2008 people are still allowed to poison the air in bars with tobacco smoke. Sad but true. Maybe we should start having smokefree Sundays too, to see how wonderful it can be?


{% extends "base.html" %} {% block head %} {% endblock %} {% block body %}
Reading the about page is highly recommended.
Data Source
Retentionizer expects csv data to have headers, with the first column named 't' representing time periods, starting at 0, counting up. Each additional column represents a cohort to model, as a survival percentage. The first cell (at t=0) for each cohort must be 1. Survival %s are expressed as decimal numbers. You can view a valid example csv file here , which contains the two cohorts from the original Fader & Hardie paper.
Settings


JSON playpen with jquery from: https://jsonplaceholder.typicode.com/
note: $.getJSON works but you cant get success and failure callbacks so you need to us $.ajax


LSTM recurrent neural network that learns from YouTube video transcripts and generates scripts to be acted out on the RobotDoesX YouTube channel.


SP1 - Payload
Overview
Test the motion of the base under payload.
Usage
- Start with a light payload.
- Connfigure speed settings appropriately
- Press start
- It will map out a square
- Repeat with a heavier payload and/or different surface, speed settings
Errata
This is quite inaccurate - it is just setting 'simple' goals relative to each side or
turn's starting position and ignoring accumulated errors.


Smashing The Stack Dot Org!
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# whoami
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These are not the droids you are looking for...
Move along...
Still Under construction... sorry!


i
tot!
 You usually...
...Find people you know well and who share your interests.
...Either find one person and converse (telling all of your ambitions, achievements) or organize a big game for all to play.
...Go and wait for others to come to you.
...Find the largest group of people & become the center of the conversation.
Do it. Who cares?
...Do the dare anyways. Your friends' opinions of you mean more than your dignity.
...Protest to the question. Why shouldn't you just get another one?
...Can't decide, so they skip you.
Question 3: Which movie would interest you the most?
Your favorite (you got all of your friends into it.)
That small-time indy flick with the amazing actors.
The latest box-office smash
Whatever you feel like at the time.
Question 4: On a date, how would the ordering go?
You get whatever sounds good at the time.
You get whatever your date gets.
You get what you've never tried.
You help your date decide what to get..
Question 5: Happy birthday! Your ideal party is...
A surprise party
Anything fun, as long as you get to plan it.
A pool, beach, or dance party: Lots of people, loud music, etc.
Your closest friends, out to a coffee shop, then to a spa.
Result
Score =
Correct answers:


View How Do I Log Into Pearson Realize Images. How to log in to pearsonrealize website подробнее. Once logged in, click the redeem button on the bottom toolbar.
For registration questions, please use the pearson vue customer. How do i learn topics covered by a typical computer science degree? This video will tell you how to log into pearson realize using google classroom.
For the first time, i'm sharing my full, unedited letters not only did i have the most fun with these teachers, but they were also more likely to advocate for me enthusiastically in their letter.
Pte academic exam is indeed the fast and fair english test. How do i send my scores to an institution? Pearson is not sensitive to linear transformations of the data. During the day of my exam, the examiners were very professional and strict with the rules.


The organisation size is used to calculate your funding level. Changing this selection will reset your funding level.
Organisation size determines funding
The organisation size is used to calculate your funding level. Changing this selection will reset your funding level.
Organisation size determines funding
The organisation size is used to calculate your funding level. Changing this selection will reset your funding level.
Turnover
If we decide to award you funding you must be eligible to receive State aid at the point of the award.
If you are found to be ineligible, we will withdraw our offer.


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Compared with conventional agriculture, organic farming uses fewer pesticides, reduces soil erosion, decreases nitrate leaching into groundwater and surface water, and recycles animal wastes back into the farm. These benefits are counterbalanced by higher food costs for consumers and generally lower yields.
Its start slow and grows big ….. Vermicompost contain all essential nutrients as well as micro-organisms. Below table gives and insight idea…….. Plants grown with GovardhanVermicompost grow bigger, faster, with more vigour, more nutrients, and are much more resistant to illnesses. Using Vermicompost will help the plants we eat and use everyday to be heartier, healthier and more nutritious. Stronger plants means bigger yields as well as less transportation and storage waste. Healthier food means healthier people. Join us in creating opportunities to live organically and in harmony.
Vermicomposting is the process by which worms are used to convert organic materials (Animal Dung) into a humus-like material known as Vermin-Compost. It has a natural complex of fertilizing organic compounds, micro and macro elements, and micro-organisms help plans to grow big, healthy and fast by the way to enrich the soil with active ingredients.


GPU/CPU Memory Stack Allocator
Table of Contents
In this post I’ll experiment an idea to keep pointers of a memory block between CPU and GPU. The motivation here is to allow ourselves to allocate memory and instantiate objects on CPU side and be able to use their memory addresses in GPU.
Of course addresses change after we copy our data to the GPU! But I want to use a very basic idea: store memory address offsets instead of actual memory addresses.
To make things easier (or possible) I’ll will use my own memory allocator, which will provide offsets instead of addresses whenever you allocate new blocks of memory.
Memory Stack Allocator⌗
There are several types of memory allocators out there with lots of cool features, I’ll pick one of the simplest: the Stack Allocator.
The Stack Allocator works just like a stack. Memory blocks are allocated
contiguously, one after the other. The image bellow shows 3 allocated blocks,
with indices 0
, 1
and 2
. The pointer 3
represents what will be the
location of the next allocated block. c
is the total capacity of the stack.
Being a stack, you are not allowed to free any block that is not in
the top. So if we want to free the block 1
, 2
will be also destroyed.
If the stack never changes in size or move in memory, we could just return
the actual address of each block. But that is not our goal here.
Memory Offsets⌗
Remember, we want to send data to the GPU and be able to use the same indices to access our data (just like if we had an array). The solution here is to return the offset (in bytes) of the allocated block.
Imagine our previous example: If block 0
has 64 bytes in size, block 1
has 640 bytes, and block 2
has 100 bytes. The pointers to these blocks
will be respectively 0
, 64
and 704
.
Implementation⌗
So now, instead of a pointer we may have an AddressIndex
(this is just
an arbitrary name) that will store the stack offset:
struct AddressIndex {
AddressIndex(std::size_t id) : id(id) {}
const std::size_t id;
};
Notice that we could define some rules, such as an address index with id 0
representing nullptr
(given the proper modifications).
We will need to access the stack whenever we access our allocated objects – unless we store the pointer as well. It is ok for me, since the goal here is to ease the task of keeping the relations between data.
The MemoryStackAllocator
class interface goes like this:
class MemoryStackAllocator {
public:
MemoryStackAllocator(std::size_t capacity_in_bytes);
// The "push" method of our stack
template<typename T, class... P>
AddressIndex allocate(P &&... params);
// The "pop" method, free all blocks down to the given marker
void freeTo(AddressIndex handle);
// The access for a given stack element (not just "top")
template<typename T>
T *get(AddressIndex handle);
private:
// Stack memory
u8 * data_;
// Total stack memory size in bytes
std::size_t capacity_;
// Index to the top of the stack
std::size_t marker_;
};
We could reproduce our example this way:
struct A {...}; // 64 bytes
struct B {...}; // 640 bytes
struct C {...}; // 100 bytes
// create a stack with 1kB of capacity
MemoryStackAllocator stack_allocator(1024);
// allocate our objects
auto a = stack_allocator.allocate<A>(/*A ctor params*/);
auto b = stack_allocator.allocate<B>(/*B ctor params*/);
auto c = stack_allocator.allocate<C>(/*C ctor params*/);
// Now, if we want to access each object we do
stack_allocator.get<A>(a)->... // A method, field..
stack_allocator.get<B>(b)->... // B method, field..
stack_allocator.get<C>(c)->... // C method, field..
I know, that is not convenient. But this is just as simple as it can be.
CPU -> GPU⌗
The cool thing is that we can easily allocate and prepare our memory in CPU side and send it all to the GPU (as normally happens), but access data the exact same way.
Again, this is just an alternative.  It really depends on your goals here.


| Name | Type | Format | Description |
|---|---|---|---|
approvalLimitDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS'Z' |
The date by which the Request must be approved. This element appears only when integrated with Concur Travel. |
approvalStatus |
object |
Approval Status |
The approval status of the Request. |
approved |
boolean |
- | Indicates whether this Request is approved. |
approver |
object |
Employee |
The approver to whom the Request was sent. |
authorizedDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS'Z' |
For approved Request, the date at which the approval process was completed. |
businessPurpose |
string |
- | The business purpose of the Request. |
canceledPostApproval |
boolean |
- | Indicates whether this Request was canceledPostApproval . |
cashAdvances |
object |
ResourceLink |
The list of cash advances for this Request. |
closed |
boolean |
- | Indicates whether this Request is closed. |
comment |
string |
- | The last comment attached to this Request. |
comments |
object |
ResourceLink |
The list of comments for this Request. |
creationDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS'Z' |
The date the Request was created. |
custom1 to custom20 |
object |
CustomField |
The details from the Custom fields. These fields may not have data, depending on the configuration. |
endDate |
date |
[ISO 8601] yyyy-MM-dd |
The end date of the Request. |
endTime |
time |
[ISO 8601] yyyy-MM-dd |
The end time of the Request. |
everSentBack |
boolean |
- | Indicates whether the Request has ever been sent back to the employee. |
exceptions |
object |
ResourceLink |
The list of exceptions that have been raised to this Request. |
expenses |
array |
ResourceLink |
Expected expenses attached to this Request. |
extensionOf |
object |
RequestLink |
The Request that this Request is an extension of, or addendum to. |
highestExceptionLevel |
string |
- | The highest level of exception contained in this Request. Supported values: WARNING , ERROR , and NONE |
href |
string |
[RFC 3986] | Hyperlink to the resource for this Request. |
id |
string |
- | The unique identifier of the Request. |
lastModified |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS'Z' |
The date the Request was last modified. |
mainDestination |
object |
Location |
The main destination of the Request. |
name |
string |
- | The name of the Request. |
owner |
object |
Employee |
The employee who owns the Request. |
pendingApproval |
boolean |
- | Indicates whether this Request is pending approval. |
policy |
object |
ResourceLink |
The policy that applies to the Request. |
requestId |
string |
4 to 6 alphanumeric characters | The public key of the Request (unique per customer). |
startDate |
date |
[ISO 8601] yyyy-MM-dd |
The start date of the Request. |
startTime |
time |
[ISO 8601] yyyy-MM-dd |
The start time of the Request. |
submitDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS'Z' |
The date the Request was submitted (last submit date in case of recall). |
totalApprovedAmount |
object |
Amount |
The total amount of approved expected expenses in the Request, expressed in the reimbursement currency of the employee at the time they created the Request. |
totalPostedAmount |
object |
Amount |
The total amount of the Request, expressed in the reimbursement currency of the employee at the time they created the Request. |
totalRemainingAmount |
object |
Amount |
The total amount not included in an Expense report, expressed in the reimbursement currency of the employee at the time they created the Request. |
travelAgency |
object |
ResourceLink |
The travel agency office that is managing the trip associated to this Request. |
operations |
array |
Link |
Links to operations available for the Request, depends on the current workflow status. |
type |
object |
RequestType |
The type of the Request, inherited from the Request Policy Type. |
| Name | Type | Format | Description |
|---|---|---|---|
value |
number |
- | Required The amount in the defined currency. |
currency |
string |
[ISO 4217:2015] | Required The 3-letter ISO 4217 code for the currency in which the amount is expressed. |
| Name | Type | Format | Description |
|---|---|---|---|
code |
string |
- | The code for the approval status of the Request. Supported values: NOT_SUBMITTED , SUBMITTED , APPROVED , CANCELED , or SENTBACK |
name |
string |
- | The approval status of the Request in the current user’s language. |
| Name | Type | Format | Description |
|---|---|---|---|
amountRequested |
object |
Amount |
The amount of the cash advance in the Request, expressed in the reimbursement currency of the employee at the time they created the cash advance. |
approvalStatus |
object |
Cash Advance Approval Status |
The approval status of the cash advance. |
cashAdvanceId |
string |
- | The unique identifier of the cash advance. |
comment |
string |
- | The last comment related to this cash advance. |
exchangeRate |
object |
Exchange Rate |
The exchange rate that applies to the cash advance. |
issueDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS |
The date the cash advance was issued. |
requestDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS |
The date the cash advance was submitted (last submit date in case of recall). |
| Name | Type | Format | Description |
|---|---|---|---|
code |
string |
- | The code for the approval status of the cash advance. Supported values: C_PEND , C_APPR , C_COMP , C_FILE , C_ISSU , C_NISU , C_NOTF , C_PECA , or C_REJE |
name |
string |
- | The approval status of the cash advance in the current user’s language. |
| Name | Type | Format | Description |
|---|---|---|---|
author |
object |
Employee |
The employee who has created the comment in the expected expense. |
creationDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS |
Creation date of the comment. |
isLatest |
boolean |
- | If true , the comment has been edited since the last workflow transition. |
value |
string |
- | The value of the comment. |
| Name | Type | Format | Description |
|---|---|---|---|
code |
string |
- | The short code for the list item. For non-list fields, this value will be blank. |
value |
string |
- | The value of the non-list item. For list fields, this is the unique id of the list item. |
href |
string |
- | The link to get this list item on the list service. Empty for non-list items. |
Retrieving the listItemId
requires to call the List API, which is currently being worked on for externalisation. In the meantime, to fill in a custom list item for the creation of a Request or an Expected Expense, clients may use one of the following workaround:
| Name | Type | Format | Description |
|---|---|---|---|
firstName |
string |
- | The first name of the employee. |
href |
string |
[RFC 3986] | Hyperlink to the resource. |
id |
string |
[RFC 4122] | Unique identifier of the related object. |
lastName |
string |
- | The last name of the employee. |
middleInitial |
string |
- | The middle initial of the employee. |
template |
string |
- | Hyperlink template to the resource. |
| Name | Type | Format | Description |
|---|---|---|---|
code |
string |
- | The system exception code defined for the exception. Example: BADCODE |
isBlocking |
boolean |
- | Defines whether the exception will prevent the Request from being submitted. |
level |
integer |
- | The numeric level associated with the exception. Example: 99 |
message |
string |
- | The user facing message defined for the exception. |
source |
array |
Exception source |
The source that has raised the exception. |
parameters |
map |
missingFields : array of missing field labelsmissingFieldsIds : array of missing field ids |
For missing fields exceptions, additional values giving more label and ids of the missing fields. Example : parameters : { "missingFields" : ["Request Name", "Purpose"], "missingFieldsIds" : [ "Name", "Purpose" ] } |
| Name | Type | Format | Description |
|---|---|---|---|
href |
string |
[RFC 3986] | Hyperlink to the resource. |
id |
string |
[RFC 4122] | Unique identifier of the source. |
type |
string |
- | Defines the type of the source. Supported values: ALLOCATION , CASH_ADVANCE , EXPENSE , and HEADER |
| Name | Type | Format | Description |
|---|---|---|---|
rel |
string |
[RFC 5988] | Relation type as defined by the server. There are registered relation types listed in RFC 5988 6.2.2. Initial Registry Contents including pagination relation types of next, prev, first and last. |
href |
string |
[RFC 3986] | Hyperlink to the resource. |
| Name | Type | Format | Description |
|---|---|---|---|
data |
array |
Request |
List of Requests in the page requested. |
operations |
array |
Link | Links to next, prev, first and last pages. |
| Name | Type | Format | Description |
|---|---|---|---|
| - | array |
Request Policy |
List of active Requests policies for a given user. |
| Name | Type | Format | Description |
|---|---|---|---|
city |
string |
- | Required for all city location type (not airport, or rail station) The city name of the location. |
countryCode |
string |
[ISO 3166-1] | Required if city or name is used The ISO 3166-1 country code. |
countrySubDivisionCode |
string |
[ISO 3166-2] | The ISO 3166-2 country sub code. |
iataCode |
string |
- | The IATA code of an airport location. |
id |
string |
- | The id of the location. |
latitude |
number |
- | The latitude of the location. |
locationCode |
string |
- | Required if rail is used The code of the location. |
locationType |
string |
- | Required if rail is used The type of the location. |
longitude |
number |
- | The longitude of the location. |
name |
string |
- | Required for rail station The name of the location. Always provide the countryCode value in addition to the name . |
Below are the different node expected in the POST endpoints by location type (City, Rail station, or Airport) - example for endLocation
field:
Airport
"endLocation": {
"city": "Moscow",
"name": "Sheremetyevo",
"countryCode": "RU",
"iataCode": "SOV"
}
City
"endLocation": {
"city": "Vienna",
"countryCode": "AT"
}
Rail station (locationCode
exists, locationType
depends of rail provider)
"endLocation": {
"name": "MARSEILLE ST CHARLES",
"countryCode": "FR",
"locationCode": "FRMSC",
"locationType": "RAIL_2C"
}
Location types for Rail :
| Location Type | Railway company |
|---|---|
RAIL_0Z |
Swiss Federal Railways |
RAIL_2A |
Deutsche Bahn AG |
RAIL_2C |
SNCF |
RAIL_2H |
Thalys International |
RAIL_2R |
VIA Rail Canada Inc. |
RAIL_2V |
Amtrak |
RAIL_9F |
Eurostar International Limited |
RAIL_XH |
China Railway |
RAIL_Z0 |
UK Rail |
STD |
Standard rail locations |
| Name | Type | Format | Description |
|---|---|---|---|
href |
string |
[RFC 3986] | Hyperlink to the resource. |
id |
string |
[RFC 4122] | Unique identifier of the related object. |
template |
string |
- | Hyperlink template to the resource. |
| Name | Type | Format | Description |
|---|---|---|---|
requestId |
string |
4 to 6 alphanumeric characters | The public key of the Request (unique per customer). |
| Name | Type | Format | Description |
|---|---|---|---|
href |
string |
[RFC 3986] | Hyperlink to the resource for this Request policy. |
id |
string |
- | The Request policy unique identifier. |
name |
string |
- | The name of the Request policy. |
| Name | Type | Format | Description |
|---|---|---|---|
code |
string |
- | The code of the type inherited from the Request Policy type. |
label |
string |
- | The label of the type inherited from the Request Policy Type. |
| Name | Type | Format | Description |
|---|---|---|---|
allocations |
object |
Allocation |
The details of the allocations for this expected expense. |
approvedAmount |
object |
Amount |
The approved amount of the expected expense entry, in the transaction currency of the Request. |
budgetAccrualDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS'Z' |
The date to determine which budgets are affected. |
businessPurpose |
string |
- | The business purpose of the Request entry. |
comments |
object |
ResourceLink |
The list of comments for this expected expense. |
custom1 to custom40 |
object |
CustomField |
The details from the Custom fields. These fields may not have data, depending on the configuration. |
exchangeRate |
object |
Exchange Rate |
The exchange rate that applies to the entry. |
expenseType |
object |
Expense Type |
The expense type of the entry. Required for expected expenses, automatically set for segments depending on the SegmentType code. |
href |
string |
[RFC 3986] | Hyperlink to the resource for this Request entry. |
id |
string |
- | The unique identifier of the expected expense entry. |
lastComment |
string |
- | The last comment (most recent) of the expected expense entry. |
lastModifiedDate |
timestamp |
[RFC 3339] | The date when this expected expense was last modified. |
location |
object |
Location |
The location of the expected expense entry. |
orgUnit1 to orgUnit6 |
object |
Amount |
The details from the Custom fields. These fields may not have data, depending on the configuration. |
postedAmount |
object |
Amount |
The posted amount of the expected expense entry, in the transaction currency of the Request. |
parentRequest |
object |
ResourceLink |
The parent Request of the expected expense. |
remainingAmount |
object |
Amount |
The remaining amount of the expected expense entry, in the transaction currency of the Request. |
source |
enum |
- | The source that created the expected expense. Supported values: CASH_ADVANCE or TRAVEL_ALLOWANCE . This field will be empty in any other case |
transactionAmount |
object |
Amount |
Required The amount of the expected expense entry, in the transaction currency paid to the vendor. |
transactionDate |
timestamp |
[RFC 3339] yyyy-MM-dd'T'HH:mm:ss.SSS'Z' |
Required The date of the transaction. |
travelAllowance |
object |
Travel Allowance |
The Travel allowance. |
tripData |
object |
Trip Data |
The description of the trip. |
vendor |
object |
Vendor |
The vendor of the expected expense entry. |
| Name | Type | Format | Description |
|---|---|---|---|
allocationAmount |
object |
Amount |
The amount of the allocation calculated with the percentage value multiplied by the transaction amount on the expected expense. This amount is given in the transaction’s currency and rounded to eight digits after the decimal point. |
approvedAmount |
object |
Amount |
The amount of the allocation calculated with the percentage value multiplied by the approved amount on the expected expense. This amount is given in the user’s currency and rounded to eight digits after the decimal point. |
allocationId |
string |
- | The unique allocation identifier. |
custom1 to custom20 |
object |
CustomField |
The details from the Custom fields. These fields may not have data, depending on the configuration. |
expenseId |
string |
- | The unique identifier of the expected expense associated with the allocation. |
percentEdited |
boolean |
- | Whether the allocation percent has been edited. |
percentage |
number |
- | The percentage of the total expected expense that this allocation represents. |
postedAmount |
object |
Amount |
The amount of the allocation calculated with the percentage value multiplied by the posted amount on the expected expense. This amount is given in the user’s currency and rounded to eight digits after the decimal point. |
systemAllocation |
boolean |
- | Whether the allocation is a system allocation, usually hidden from the user. If displayed to the user, should be read-only. |
| Name | Type | Format | Description |
|---|---|---|---|
operation |
string |
- | Exchange rate operation. Supported values: MULTIPLY , DIVIDE |
value |
number |
- | Exchange rate value. |
| Name | Type | Format | Description |
|---|---|---|---|
id |
string |
- | Required Unique identifier of the expense type. |
name |
string |
- | Name of the expense type. |
| Name | Type | Format | Description |
|---|---|---|---|
code |
string |
- | The short code of the list item. |
value |
string |
- | Unique identifier of the list item. |
href |
string |
[RFC 3986] | Hyperlink to the resource for the list item. |
| Name | Type | Format | Description |
|---|---|---|---|
class |
list |
List Item Field |
The booking class of the segment leg. |
classOfService |
string |
- | The class of service of the segment leg. For example, in the case of an air segment, this field would contain the one-letter booking code: Y for economy class, or F for first class. |
comment |
string |
- | Contains the last comment saved in this segment leg. |
custom1 to custom40 |
object |
CustomField |
The details from the Custom fields. These fields may not have data, depending on the configuration. |
endDate |
date |
[ISO 8601] YYYY-MM-DD |
The date of the end of this segment leg. It represents the arrival date of AIRFR and TRAIN segments, check out date for HOTEL , or drop off for CARRT . |
endLocation |
object |
ResourceLink |
The location where this segment leg arrives. For example, the arrival location for an air segment. |
endLocationDetail |
string |
- | Details about the end location. This would contain details about the name of a hotel, or some details about a car rental agency for example. |
endTime |
time |
[ISO 8601] HH:MM |
The time for the end of this segment leg. |
id |
string |
- | The unique identifier of the segment leg. |
returnLeg |
boolean |
- | Indicates whether this leg is the return leg of a round trip. In case of a ROUND_TRIP , if not explicitly set, the second segment leg will be considered as the return leg. |
startDate |
date |
[ISO 8601] YYYY-MM-DD |
The date of the beginning of this segment leg. |
startLocation |
object |
ResourceLink |
The start location of this segment leg. This would be the departure location for an air segment for example. |
startLocationDetail |
string |
- | Details about the start location. This would contain details about the name of a hotel, or some details about a car rental agency for example. |
startTime |
time |
[ISO 8601] HH:MM |
The time for the beginning of this segment leg. |
segmentLocator |
string |
- | This is the identifier for Concur Travel segments (if applicable). |
vendorName |
string |
- | Contains the vendor description of the segment leg. |
| Name | Type | Format | Description |
|---|---|---|---|
category |
enum |
- | Describes the category of this segment type. Supported values: REQ_SEG_AIRFR , REQ_SEG_CARRT , REQ_SEG_HOTEL , REQ_SEG_LIMOF , REQ_SEG_RAILF , REQ_SEG_TAXIF , REQ_SEG_MISC , REQ_SEG_PARKG , REQ_SEG_DININ , REQ_SEG_EVENT |
code |
string |
- | Required The code of the segment type. Supported values: AIRFR , CARRT , HOTEL , LIMOF , RAILF , TAXIF , MISC , PARKG , DININ , EVENT or custom codes |
It can be REQ_SEG_AIRFR
/ AIRFR
for a regular air segment, or REQ_SEG_AIRFR
/ 10325
for a custom air segment.
Example:
{
"category": "REQ_SEG_AIRFR",
"code": "AIRFR"
}
| Name | Type | Format | Description |
|---|---|---|---|
emailAddress |
string |
- | The travel agency email address. |
id |
string |
- | The travel agency unique identifier. |
name |
string |
- | The travel agency office name. |
proposalType |
string |
- | The travel agency proposal type. Supported values: CWTF , AEBT , API |
| Name | Type | Format | Description |
|---|---|---|---|
dailyTravelAllowanceId |
string |
- | The fixed daily travel allowance id associated with the expected expense. |
| Name | Type | Format | Description |
|---|---|---|---|
agencyBooked |
boolean |
- | If true , this travel is (or has to be) handled by a travel agency. |
legs |
list |
Segment Leg |
The list of the legs of the travel. |
tripType |
string |
- | Indicates the type of this trip. Supported values: ONE_WAY , ROUND_TRIP , or MULTI_STOPS . If not provided, will be detected from the given legs. |
segmentType |
object |
Segment Type |
Required The type of the segment. |
selfBooked |
boolean |
- | If true , this travel has been reserved by Concur Travel, or if Concur Travel has retrieved the trip information in the GDS. |
| Name | Type | Format | Description |
|---|---|---|---|
id |
string |
- | The vendor identifier of the entry. |
name |
string |
- | The vendor description of the entry. |


I just started using chemical substances this summer, at age 25. I'd been doing ecstasy regularly, and I wanted to try mushrooms. This would be my first time trying a psychedelic substance...and on top of that, alone.
I got home from work on a Monday night, and wound up having a fight on the phone with my younger brother. I just got hold of 5 fresh average sized shrooms. I was very eager to try them and did a lot of reading up on trip reports and effects. So, I felt confident I could handle it (thinking I'd take a small dose the first time). After I got back from the video store with a movie to watch while tripping, I blended up my shroom concoction. I blended two mushrooms with a vitamin C tablet and a glass of orange juice. I drank this mixture down around 8:00 pm. I started watching tv.  After an hour of not really feeling much, I decided to go out for a walk in my neighborhood.
I started walking around the block, and I started to feel a little bit of the mushrooms kicking it. My legs felt a little weak and tingly. I noticed the beauty in the trees and everything around me seemed really clear. Sounds and smells were very intense.
I came back in after a half an hour, and decided to eat two more mushrooms...seeing that I really wasn't feeling much (after 1.5 hours). I had some deep trance playing in the background (really cool when I'm on E).  After the joint, I ate one more shroom (for a total of 5).
Fifteen minutes after smoking, it hit me! I had an intense body buzz. So, I went to the washroom and saw that my pupils were pretty dilated. I stared at the bathroom light, and then down at the mirror. I saw what appeared to be the bathroom light, and watched it morph into a colorful circle that started to fly around on the mirror like a spaceship.
At this time, I laid down on the couch, as the weed was making me a little tired. So, I closed my eyes and started to let my imagination run wild. I was seeing all kinds of weird shapes and objects. The minute I tried to concentrate on something and focus, everything changed...kind of like one of those crazy computer screen savers. It was almost like flipping to a different tv channel every 3 seconds.
I then kinda lost track of time as I was lost in my imagination. I started looking around the room...and I felt like a little boy scared in his bedroom, afraid of monsters. The door handle on my closet door looked as if it was some man's face (all white) peeking out at me. I kept glancing around the room and things looked scary. I then said to myself that I'm tripping, and I was ok then. I then started to concentrate on the trance music I was playing. I had a really intense body buzz, which I believe was peaking. I curled up into a little ball on the couch with a blanket covering me. The strange thing was that I was having these slight convulsions, kinda like when you get the chills...but it wasn't painful. When they were over, I smiled and started giggling.
I started to come down and decided to go to bed...around 12:30-1:00 am. It was hard to get to sleep. The comforter that I threw over myself was giving me this intense feeling against my body (like when someone touches you on E).
I eventually got to sleep...and felt wonderful in the morning. I want to try shrooms again...probably go for like 5 or 6 shrooms all at once.
Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid.


src/app/student/student-routing.module.ts
import { OnlineClassLinkComponent } from './student-pages/online-class-link/online-class-link.component';
import { OnlineeClassComponent } from './student-pages/onlinee-class/onlinee-class.component';
import { StudentViewEnrollmentComponent } from './student-pages/student-enrollment-details/student-view-enrollment/student-view-enrollment.component';
import { StudentInstitutesComponent } from './student-institutes/student-institutes.component';
import { StudentViewAnnouncementComponent } from './student-pages/student-announcements/student-view-announcement/student-view-announcement.component';
import { StudentHomeComponent } from './student-home/student-home.component';
import { StudentComponent } from './student.component';
import { NgModule } from '@angular/core';
import { Routes, RouterModule } from '@angular/router';
import { StudentDashboardComponent } from './student-dashboard/student-dashboard.component';
import { StudentAnnouncementsComponent } from './student-pages/student-announcements/student-announcements.component';
import { StudentScheduleComponent } from './student-pages/student-schedule/student-schedule.component';
import { StudentAttendanceComponent } from './student-pages/student-attendance/student-attendance.component';
import { StudentPerformanceReportComponent } from './student-pages/student-performance-report/student-performance-report.component';
import { StudentStudyMaterialComponent } from './student-pages/student-study-material/student-study-material.component';
import { StudentForumsChatsComponent } from './student-pages/student-forums-chats/student-forums-chats.component';
import { StudentEnrollmentDetailsComponent } from './student-pages/student-enrollment-details/student-enrollment-details.component';
import { StudentViewScheduleComponent } from './student-pages/student-schedule/student-view-schedule/student-view-schedule.component';
import { StudentMeetingComponent } from './student-pages/student-meeting/student-meeting.component';
import { StudentMentoringComponent } from './student-pages/student-mentoring/student-mentoring.component';
import { StudentForumCommentComponent } from './student-pages/student-forums-chats/student-forum-comment/student-forum-comment.component';
import { StudentEaLiveGuard } from '../services/auth-services/auth-guards/student-ealive-auth.guard';
import { StudentTestComponent } from './student-pages/student-test/student-test.component';
const routes: Routes = [
{
path: '',
component: StudentComponent,
children: [
{
path: '',
redirectTo: 'home',
pathMatch: 'full',
},
{
path: 'home',
component: StudentHomeComponent,
},
{
path: 'my-institutes',
component: StudentInstitutesComponent,
},
{
path: 'dashboard/:id',
component: StudentDashboardComponent,
},
{
path: 'announcements/:id',
component: StudentAnnouncementsComponent,
},
{
path: 'view-announcement/:id',
component: StudentViewAnnouncementComponent,
},
{
path: 'schedule/:id',
component: StudentScheduleComponent,
},
{
path: 'view-schedule/:id',
component: StudentViewScheduleComponent,
},
{
path: 'attendance/:id',
component: StudentAttendanceComponent,
},
{
path: 'performanceReport/:id',
component: StudentPerformanceReportComponent,
},
{
path: 'studentMaterial/:id',
component: StudentStudyMaterialComponent,
},
{
path: 'forumsAndChats/:id',
component: StudentForumsChatsComponent,
},
{
path: 'forumsAndChats/comments/:id',
component: StudentForumCommentComponent,
},
{
path: 'enrollmentDetails/:id',
component: StudentEnrollmentDetailsComponent,
},
{
path: 'viewEnrollment/:id',
component: StudentViewEnrollmentComponent,
},
{
path: 'meeting/:id',
component: StudentMeetingComponent,
},
{
path: 'mentoring/:id',
component: StudentMentoringComponent,
},
{
path: 'tests/:id',
component: StudentTestComponent,
},
{
path: 'onlineClasses/:id',
component: OnlineeClassComponent,
canActivate: [StudentEaLiveGuard],
},
{
path: 'onlineClassLinks/:id',
component: OnlineClassLinkComponent,
canActivate: [StudentEaLiveGuard],
},
{
path: '**',
redirectTo: 'home',
},
],
},
];
@NgModule({
imports: [RouterModule.forChild(routes)],
exports: [RouterModule],
})
export class StudentRoutingModule {}


Class Solver
Provides methods for solving equations.
Inheritance
Namespace: Lapis.Math.Numerical
Assembly: Lapis.Math.Numerical.dll
Syntax
public static class Solver : Object
Methods
Bisection(Func<Real, Real>, Real, Real, Double)
Solve the equation in the specified range with the bisection method.
Declaration
public static Real Bisection(Func<Real, Real> func, Real lower, Real upper, double accuracy = 1E-08)
Parameters
| Type | Name | Description |
|---|---|---|
| System.Func<Real, Real> | func | The equation to solve. |
| Real | lower | The lower limit. |
| Real | upper | The upper limit. |
| System.Double | accuracy | The accuracy. |
Returns
| Type | Description |
|---|---|
| Real | A solution of |
Exceptions
| Type | Condition |
|---|---|
| System.ArgumentNullException |
|
| System.ArgumentOutOfRangeException |
|
| System.ArithmeticException | Cannot find the solution, or the maximum iterations were reached. |
Bisection(Func<Double, Double>, Double, Double, Double)
Solve the equation in the specified range with the bisection method.
Declaration
public static double Bisection(Func<double, double> func, double lower, double upper, double accuracy = 1E-08)
Parameters
| Type | Name | Description |
|---|---|---|
| System.Func<System.Double, System.Double> | func | The equation to solve. |
| System.Double | lower | The lower limit. |
| System.Double | upper | The upper limit. |
| System.Double | accuracy | The accuracy. |
Returns
| Type | Description |
|---|---|
| System.Double | A solution of |
Exceptions
| Type | Condition |
|---|---|
| System.ArgumentNullException |
|
| System.ArgumentOutOfRangeException |
|
| System.ArithmeticException | Cannot find the solution, or the maximum iterations were reached. |
Cubic(Real, Real, Real, Real)
Returns the complex solutions of a cubic equation.
Declaration
public static Tuple<Complex, Complex, Complex> Cubic(Real a, Real b, Real c, Real d)
Parameters
| Type | Name | Description |
|---|---|---|
| Real | a | The coefficient of the cubic term. |
| Real | b | The coefficient of the quadratic term. |
| Real | c | The coefficient of the linear term. |
| Real | d | The constant term. |
Returns
| Type | Description |
|---|---|
| System.Tuple<Complex, Complex, Complex> | The complex solutions of the cubic equation |
Exceptions
| Type | Condition |
|---|---|
| System.ArgumentOutOfRangeException | The coefficients are invalid. |
Quadratic(Real, Real, Real)
Returns the complex solutions of a quadratic equation.
Declaration
public static Tuple<Complex, Complex> Quadratic(Real a, Real b, Real c)
Parameters
| Type | Name | Description |
|---|---|---|
| Real | a | The coefficient of the quadratic term. |
| Real | b | The coefficient of the linear term. |
| Real | c | The constant term. |
Returns
| Type | Description |
|---|---|
| System.Tuple<Complex, Complex> | The complex solutions of the quadratic equation |
Exceptions
| Type | Condition |
|---|---|
| System.ArgumentOutOfRangeException | The coefficients are invalid. |
Quadratic(Double, Double, Double)
Returns the real solutions of a quadratic equation. An exception is thrown if the equation does not have real solutions.
Declaration
public static Tuple<double, double> Quadratic(double a, double b, double c)
Parameters
| Type | Name | Description |
|---|---|---|
| System.Double | a | The coefficient of the quadratic term. |
| System.Double | b | The coefficient of the linear term. |
| System.Double | c | The constant term. |
Returns
| Type | Description |
|---|---|
| System.Tuple<System.Double, System.Double> | The real solutions of the quadratic equation |
Exceptions
| Type | Condition |
|---|---|
| System.ArgumentOutOfRangeException | The coefficients are invalid. |
| System.ArithmeticException | The equation does not have real solutions. |
Secant(Func<Real, Real>, Real, Double)
Solve the equation with the secant method.
Declaration
public static Real Secant(Func<Real, Real> func, Real initial, double accuracy = 1E-08)
Parameters
| Type | Name | Description |
|---|---|---|
| System.Func<Real, Real> | func | The equation to solve. |
| Real | initial | An initial value. |
| System.Double | accuracy | The accuracy. |
Returns
| Type | Description |
|---|---|
| Real | A solution of |
Exceptions
| Type | Condition |
|---|---|
| System.ArgumentNullException |
|
| System.ArgumentOutOfRangeException |
|
| System.ArithmeticException | Cannot find the solution, or the maximum iterations were reached. |
Secant(Func<Double, Double>, Double, Double)
Solve the equation with the secant method.
Declaration
public static double Secant(Func<double, double> func, double initial, double accuracy = 1E-08)
Parameters
| Type | Name | Description |
|---|---|---|
| System.Func<System.Double, System.Double> | func | The equation to solve. |
| System.Double | initial | An initial value. |
| System.Double | accuracy | The accuracy. |
Returns
| Type | Description |
|---|---|
| System.Double | A solution of |
Exceptions
| Type | Condition |
|---|---|
| System.ArgumentNullException |
|
| System.ArgumentOutOfRangeException |
|
| System.ArithmeticException | Cannot find the solution, or the maximum iterations were reached. |


Keys
Description
Alt + j
Focus
Insert
Insert Card
Delete
Delete Card
Home
First Card Selection
End
Last Card Selection
Ctrl + Down Arrow
Swimlane Expand All
Ctrl + Up Arrow
Swimlane Collapse All
F2
Edit Card
Enter
Save Request
Esc
Cancel Request
Shift + UpArrow
Multi Selection By Up Arrow
Shift + Down Arrow
Multi Selection By Down Arrow
Shift + Left Arrow
Multi Selection By Left Arrow
Shift + Right Arrow
Multi Selection By Right Arrow


Joker sequel reportedly in the works
by James CoxA sequel to the hugely popular Joker origins film is reportedly in the works.
Todd Phillips' film has been a massive box office hit, it's already passed the $1 billion mark, which saw it move past Deadpool to become the highest-grossing R-rated film ever.
Joaquin Phoenix's stunning performance has led to plenty of speculation about a sequel, with the actor indicating he'd be happy to work with Phillips again and reprise the role.
A sequel is now in final-stage discussion according to The Hollywood Reporter, the publication reports that Phillips and Phoenix are "likely to reteam".
The director is set to write the screenplay for the Joker sequel along with co-writer Scott Silver, who he worked with on the script for the original.
The box office returns for Joker were enough for Warner Bros to agree to Phillips' request to direct another DC Comics origins story, rumoured to be about Batman's nemesis Lex Luthor.
A new Batman film is currently being shot by Matt Reeves, with Robert Pattinson in the lead role.
The Hollywood Reporter add that Phillips will earn around $100 million from his work on the film, after agreeing a similar percentage profit share deal to the one he negotiated for The Hangover (which cost $35 million and made $468 million).
Phillips previously said a Joker sequel couldn't just be "this wild and crazy movie", adding: "It would have to have some thematic resonance in a similar way that [Joker] does."


Highlights expression if it has no side effects and does not affect on any variable value or function return. It may be either removed or converted to a return statement.


Hello World.. Again!
Long time no blog!
Time flies when you're having fun, and these past few weeks have been pretty great on my Python adventures. Semi-related, but time also flies when you spend a lot of it at your job ;).
Kudos
Since this blog is a public ledger I feel that it would be appropriate to call out a few people that have really helped me out and enabled me to invest my time learning about Python and Django.
Evan
First, no Chipy Blog (tm) would be complete without at least a few sentences about someone that I think would be fair to say is the world's best Python mentor in the Chipy Fall 2017 group, Evan Hahn. With his help I now have a tight dev environment on my server, a slowly but surely impoving sense of development in general, and confidence that I can actually write functional software. When we have a meetup, I don't just get some guidance on what to or the a casual "that's not how you spell resopse", Evan takes the time to really illustrate concepts and practical implimentations of what we're doing and why things matter.
Ray and all my Python Pals
Some time ago some enterprising folks at my job started a Python enthusiast club where on Monday evenings we take some time to just sit down and either tackle some code challenges, or work out a problem that one of us is taking on and could use some help. Even though it's just a few short hours a week, it's a real priviledge to be able to work on my coding skills in such an awesome environment. Think group challenge night but more Ray and less introverted anxiety. Also Ray is just generally amazing. I'd go on but then this late blog would never get finished!
Callie Clay and James Beesley
In my final act of overt gushing, I'd like to call out how incredible these two people have been for me. First and foremost the love of my life Callie has been unreasonably supportive. Whether its been making me a cup of coffee before I fall asleep on my laptop or just picking up our pup from doggy daycare so I can stay late at work, she has really been the wind beneath my wings.
I'd also be remissed if I didn't give a quick shout out to my manager James B the third. Telling me to home early after my forth day in a row working late and letting a programming lunch session slip a touch longer than it's supposed to have been super helpful and appreciated.
Trello, Vim, and the URL
Part of my Hatchling journey has been more than learning the ins and outs of Python. In our session we decided that it would be useful to set up a Trello board and it's a really nice way of keeping myself grounded. As I continue to dream up new features inbetween coding sessions trying to implement much more modest ones, I can really get a sense of what I need to do and where I'm going with this project.
Vim. This is easily the best and worst thing I've ever started using while learning to code. The shortcuts are spectacular and really help you quickly zip around what you're writing and I've witnessed firsthand how insanely efficient having built-in regular expression hotkeys are but man oh man the learning curve is quite steep and I'm going to boldly come out and say some of this stuff is less than intuitive from the outside. That said, having seen the benefits when used by a pro I can safely say the pain pays off when it finally pays off
Oh, and in the event my intermittent lenghly ramblings weren't enough for you people to see what I've managed to eek out over these last few weeks (which have really felt much shorter than that) here's a URL you can visit while the server is up:
The Best Soundboard In The Universe SomedayDataBase Planning
After pontificating my hopes and dreams of what a universal soundboard generator would look like, Evan and I came to a conclusion that utilizing a postgres database and utilizing as much of Django's built-in database/model code as we can would be the right move. So it was off the the whiteboard!... Literally!
As the general idea is that you as a user would be able to make many differnent/themed soundboards you would then need a way to upload files to MY server in a way that was both safe/reasonable for me and intuitive for you. Thus we deided on a many to many relationship between the two most important models, the Sounds and Soundboard models. We took a good long look at Django's documentation and here's what we generally concluded the models should look like:
class Sound(models.Model): name = models.CharField(max_length=140) text = models.CharField(max_length=280, null=True) sound_file = models.FileField(upload_to='sounds/') user = models.ForeignKey(User, on_delete=models.CASCADE) image_file = models.FileField(upload_to='sound_images/')
class SoundBoard(models.Model): title = models.CharField(max_length=140) user = models.ForeignKey(User, on_delete=models.CASCADE)
After that was established, I finally got an explanation of what migrations are. Following this, I learned how to manually roll back migrations after adding new non-nullable fields with no defaults set. It's nice doing development work in a development environment with far off deadlines <3.
The next big challenge will be fleshing out all of the views (praise be to BootStrap) and getting a slick login/signup page to actually function. If I can do this in a reasonable timeframe I'll try to put up a new blog post detailing the process. It turns out not many have opted to try to force Django's built-in login handling code to live on the same view the as the built-in signup form. Who knows! I might just become Django famous if I can clearly show how it can all work together!
Untill next time!


Ploror688.github.io
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HTML UI & CSS syntax
This page is about everything related to the app and its HTML side and settings. Involt converts CSS classes into specified user interface element, function and its parameters. The ard class defines the Involt object.
Element structure
The most basic explanation of syntax looks like this:
ard [element] [pin] [parameters]
As a class within HTML element, it looks like this:
Example of rangeslider:
The parameters can be defined as attributes. It's useful when using inputs.
In previous cases all parameters are same as default so you don't have to define them.
The list of elements and what parameters they need check reference page.
Involt pins
Keeping the Pin-to-Pin relation is most intuitive and highly recommended to maintain readability of your code (A0 analog pin as A0 pin in app). However, pins are not only the direct representation of device pins. Treat the Involt pins as a container of values that by sending or receiving are accessible from both sides.
Probably, at some point you will notice that some things requires to send (or read) data not related to any hardware pin but from i2c/SPI sensor, some calculations or read additional data from multiplexer. In this case just include them as unused pin from pin array. For example: Arduino UNO has 6 analog read pins. If you use multiplexer (or just want to send other values) the additional values can be sent as pins A6-A(n).
The pin consist of pin type and index. The types are:
P - Send numeric value
S - Send string, S0 is not the same as P0 and is send to different array in Arduino sketch.
A - Data received from device (string and numeric)
Pins are stored in involt.pin.A, involt.pin.P, involt.pin.S arrays.
Pin P9 can be defined as class pin-P9, attribute pin="P9" or as class directly after [element] P9. You should always define pin after element name.
Parameters
The parameters determine how elements behave, you don't have to add them in specific order nor add them at all, if you use their default values.
Value
It defines the value that element is going to send on specific action. It also defines the beginning value of dynamic elements: like knob and rangeslider (default is 0). It can be numeric value or string (with S pin).
Some elements requires two values:
When string is longer than one word use HTML value attribute:
Range
Range - used to define minimum and maximum range of element. For read only default range is 0-1024 and for sending it's 0-255.
The min and max parameters are supported.
Step
The increment or decrement step of dynamic elements. Default is 1.
Function
Send additional function name to device when element event occurs so the device can react to certain events in app. The function can be triggered immediately in Arduino sketch. Check the functions page.
App settings
How to change the project name and description?
On desktop, open package.json. On mobile, edit the config.xml
How to remove the loader?
- Open settings.js
- Change the loaderOnLaunch to false
- Set default connection settings below. After that Involt will connect to selected device on launch.
- Enjoy not selecting the device each time when app is launched.
- Remember that loader is recommended when sending the project to others.
How to change the desktop window dimensions?
Open package.json and change width or height. To run app on fullscreen uncomment the fullscreen parameter.
Read-only elements update rate.
The update rate affects smoothness of updating HTML read elements. Default value is compromise between smoothness and cpu usage. Lower value will update objects almost in real time but will affect CPU usage (important especially on mobile). To change this open settings.js and change updateRate. This will not affect the connection bitrate.
Debug mode
Debug mode prints to console additional informations about what is happening in Involt and connection settings. To turn on debug mode open settings.js and change debugMode to true.


I am a pretty experienced drug user, having smoked pot heavily for 2 years, a gram a day. But that is an entirely different story. An older woman watches our house when we go on vacation. After coming back from one of these vacations I walked into the guest room and noticed a bottle of pills. Oh what a great look must have been on my face when I realized that there were 40 vicodin pills of with 10mg of hydrocodone in each pill. I had a grin from ear to ear, I quickly called my friend Marshall and told him of my find. I have taken vicodin before but only in my home in private. I thought that I would take the pills the 2nd period before lunch.  I had not eaten breakfest so that I could take them on an empty stomach, I quickly gobbled 3 pills down as the teacher turned away. I felt the same for about 25 minutes then I felt a small high, like coming up on bud. Then about 50 minutes after I had taken them I felt very very happy and talkative. I felt as if everything was ok and the world was a great place.  By the time lunch rolled around I felt as if I could do anything. I walked around and had many converations with everyone. The words just flowed out of my mouth. I was on top of the world. I felt in every conversation that I had made a meaningful connection. I was at peace with myself and with everyone else.
A total of 3 hours passed before I came down from cloud 9. I noticed that I was extremely irritable.  I just wanted to be alone and not talk to anyone. I also noticed that I was having trouble talking and listening. I could talk but it came out not making any sense. And when I spoke I could not tell if I was yelling or whispering. I felt semi sick but overall I was ok.
Experience Reports are the writings and opinions of the individual authors who submit them.
Some of the activities described are dangerous and/or illegal and none are recommended by Erowid.


SDDI Discovery Service - Cookie Statement
The SDDI Discovery Service allows a user to select the point of login from a pre-defined list of operators (the Identity Providers). This service remembers that choice in a session cookie.For convenience, it is possible that the user persistently stores that selection. This would supress the IdP selection dialog until the user re-sets this choice.
Name of the service
SDDI Discovery Service - ds.sddi.secure-dimensions.dePurpose of using cookies
The SDDI Discovery Service - this service - stores the user's IdP selection in a session cookie to be able to support Single-Sign-On with the SDDI Federation. This service uses a persistent cookie to remember the user's IdP selection persistently.None of the cookies stores or links to personal data.
Session Cookies
| Cookie name | Purpose | Session/Persistent cookie? |
|---|---|---|
| cookieconsent_status | stores your acceptance of the Cookie discalimer | Persistent |
| SDDI_redirect_user_idp | stores the settings to temporarily redirect users transparently to their last selected IdP | Persistent | _saml_idp | SAML2 specification comliant cookie to store the list of IdPs visited by the user | Session | SDDI_saml_sp | It is used to display help/contact information on a page | Session | SDDI_redirect_state | Signals that the IdP discovery dialog can be skipped. | Session |


--- title: EBSD Orientation Anaylsis sidebar: documentation_sidebar permalink: EBSDOrientationAnalysis.html folder: documentation toc: false ---
Here we discuss tools for the analysis of EBSD data which are independent of its spatial coordinates. For spatial analysis, we refer to this page. Let us first import some EBSD data:
{% highlight matlab %} plotx2east ebsd = EBSD.load(fullfile(mtexDataPath,'EBSD','Forsterite.ctf'),... 'convertEuler2SpatialReferenceFrame'); plot(ebsd) {% endhighlight %}We start our investigations of the Forsterite phase by plotting some pole figures
{% highlight matlab %} cs = ebsd('Forsterite').CS % the crystal symmetry of the forsterite phase h = [Miller(1,0,0,cs),Miller(0,1,0,cs),Miller(0,0,1,cs)]; plotPDF(ebsd('Forsterite').orientations,h,'antipodal') {% endhighlight %} {% highlight plaintext %} cs = crystalSymmetry mineral : Forsterite color : LightSkyBlue symmetry: mmm elements: 8 a, b, c : 4.8, 10, 6 I'm plotting 1250 random orientations out of 152345 given orientations You can specify the the number points by the option "points". The option "all" ensures that all data are plotted {% endhighlight %}From the {100} pole figure, we might suspect a fibre texture present in our data. Let's check this. First, we determine the vector orthogonal to fibre in the {100} pole figure
{% highlight matlab %} % the orientations of the Forsterite phase ori = ebsd('Forsterite').orientations % the vectors in the 100 pole figure r = ori * Miller(1,0,0,ori.CS) % the vector best orthogonal to all r rOrth = perp(r) % output hold on plot(rOrth) hold off {% endhighlight %} {% highlight plaintext %} ori = orientation (Forsterite → xyz) size: 152345 x 1 r = vector3d size: 152345 x 1 rOrth = vector3d antipodal: true {% endhighlight %}we can check how large is the number of orientations that are in the (100) polegigure within a 10-degree fibre around the great circle with center rOrth
. The following line gives the result in percent
Next, we want to answer the question which crystal direction is mapped to rOrth
. To this end, we look at the corresponding inverse pole figure
Surprisingly this value is significantly lower than the value we obtained we looking only at the 100 pole figure. Finally, let's plot the ODF along this fibre
{% highlight matlab %} odf = calcDensity(ebsd('Forsterite').orientations) % plot the odf along the fibre plot(odf,f) ylim([0,26]) {% endhighlight %} {% highlight plaintext %} odf = SO3FunHarmonic (Forsterite → xyz) isReal: true bandwidth: 25 weight: 1 {% endhighlight %}We see that to ODF is far from beeing constant along the fibre. Thus, together with an observation about the small fibre volume, we would reject the hypothesis of a fibre texture.
Let's finally plot the ODF in orientation space to verify our decision
{% highlight matlab %} plot(odf,'sigma') {% endhighlight %}Here we see the typical large individual spots that are typical for large grains. Thus the ODF estimated from the EBSD data and all our previous analysis suffer from the fact that too few grains have been measured. For texture analysis, it would have been favorable to measure at a lower resolution but a larger region.


See getting started for a complete setup.
Steps to get started:NgbDatepickerModule
(if you're not including NgbModule
)This component is meant to be used together with @sebgroup/bootstrap and in order for the component to get the correct appearance you need to import styles from @sebgroup/bootstrap files to your project.
For more info and examples please refer to ng-bootstrap official documentation.
For more info and examples please refer to ng-bootstrap official documentation.


--- layout: archive title: Zulip Chat Archive permalink: /stream/116395-maths/topic/comment.20in.20functor.2Elean.html ---
Do I understand correctly that this comment is no longer accurate?
https://github.com/leanprover/mathlib/blob/master/category_theory/functor.lean#L28-L29
I think it refers to behaviour of an older version of restate_axiom
.
@Scott Morrison :up:
That's right, the comment needs updating.
{% endraw %}Last updated: Apr 24 2020 at 19:02 UTC


Comparison to native element
Negative attributes
value="0"
disabled
max="0"
disables slider
Programmatic value changes
Predefined buffer position data-buffer="60"
Update buffer position
%
Update range
Destroy a plugin instance
Combination with native <details>
element
Toggle


Workspace
File
Language
Preferences
Debug
New Workspace
Open Workspace
Save Workspace
Save All Files (Cmd+E)
New (Cmd+N)
Open (Cmd+O)
Save (Cmd+S)
Save As
Close (Cmd+W)
Rename
Delete
Create Directory
Delete Path
Upload File
Download File
text
assembly_x86
autohotkey
batchfile
c_cpp
csharp
css
diff
dot
golang
html
ini
java
javascript
json
lua
makefile
markdown
objectivec
perl
php
sh
sql
mysql
vbscript
verilog
xml
Compile (Cmd+K)
Run
Workspace Side
left
right
Workspace Width
Workspace Collapsed
true
false
Menu Side
top
bottom
Editor Theme
Editor Tab Size
Editor Soft Tabs
true
false
Editor Ruler Show
true
false
Editor Ruler Column


{% extends 'layout.html' %} {% block body %}
Congrats! You found all the eggs. It only took you {{ seconds }} seconds!


Highest:
0
Score:
0
GAME OVER
How to play:
Use mouse click to jump or use keyboard controls (Space Bar or Arrow Up key).
If you Lose, or at any moment, if you want to start new game, refresh the page to start playing.


Here is my first lab.
They're all having a grand time.
Here are some random facts in the form of an unordered list.
If this question were about our top 5 favorite songs, I think it would look much different.
The woods are lovely, dark and deep
But I have promises to keep
And miles to go before I sleep,
And miles to go before I sleep.
- Robert Frost
This is the last stanza from Frost's poem, Stopping by Woods on a Snowy Evening. This is also the last part of the page. So, thanks and have a good day!


THE REPLACEMENT KILLERS 1998 A film review by Timothy Voon Copyright 1998 Timothy Voon 1 :-( for imitation Woo at its best
Cast: Chow Yun-Fat, Mira Sorvino, Michael Rooker, Kenneth Tsang, Jurgen Prochnow Director: AntoineFuqua Screenplay: Ken Sanzel
This movie is not directed by John Woo, but has Woo written all over it. There are lots of Woo imitators floating about in celluloid land and Antoine Fuqua is one of them. Fortunately, he is one of the better ones. What we have is a mesh of slowed action sequences entangled with rapid gunfire, the poetic stances of action puppets used to riddle each other with passing bullets, whilst dressed in dark traditional overcoats now the trade mark of Hong Kong action movies come to Hollywood. Not to mention the poor lighting, dark sets, gloomy overcast skies and rainy nights with a huge numbers of smoke, steam and wind generators and the resident demolition expert to blow up every available automobile, building and/or anything which stands or which closely resembles such and all in a single breath!
Excuse the static, but the plot goes - Chow/Sorvino (passports) Chinese Triad Clash (bullets fly) Police (too late) Chow/Sorvino (family talk) Triad Clash (lots of explosions) Police (too late again) Chow/Sorvino (Buddha, family, save boy) Triad Clash (more bullets and explosions) Police (Where are they?). Is there a recurring theme somewhere in here?
The first time I saw Chow Yun Fat was 15 years ago staring in a Cantonese soap opera To Catch Good People in a Net'. This soapie had most people in Hong Kong, Canton and Shang-Hai including all my Aunts tuned to their TV sets every night. If you've ever seen a Chinese soapie, you will understand that it is synonymous with the word tragedy. The point of the entire exercise is to bring grief beyond belief and a rainstorm of tears to your eyes. I haven't seen any of Chow's movies between now and then, but I can say he hasn't changed much. Chow's English isn't very good and fortunately he is given little to say except for a few monosyllable sentences to express grief, pain or anger. The lack of dialogue from Chow is otherwise adequately compensated by Sorvino, gunfire and loud explosions. Mira Sorvino shows us once again that she is not a babe or actress to be messed with, reprising the tough girl image first seen in MIMIC.
Overall, this movie has some brilliant action sequences, but is otherwise too repetitious for my liking.
Timothy Voon e-mail<EMAIL_ADDRESS>http://us.imdb.com/M/reviews_by?Tim+Voon http://www.labyrinth.net.au/~bouclier/week/movies.html
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Protein of the Month |
November 2006
MORE ON THIS MONTH’S PROTEIN
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OTHER PROTEINS OF INTEREST |
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Blood clotting, or coagulation, is a rapid response to tissue damage, where the exposure of tissue factor containing cells to the bloodstream through damage to vessel walls initiates a rapid cascade system. This enzyme cascade uses a series of enzymes to work in rapid succession to amplify a small response into a large one at the site of damage (see Figure 1). Once activated, tissue factor (TF) binds and activates factor VII (FVII), initiating the cascade. TF/FVII is activated through auto-cleavage to TF/FVIIa, which along with cofactor FVIIIa converts FIX to FIXa; FXa can then convert FX to FXa, which along with cofactor FVa converts FII (prothrombin) to FIIa (thrombin); finally FIIa converts fibrinogen to fibrin, leading to fibrin deposition and the activation of platelets to form blood clots. The activation of FXIII to FXIIIa can stabilise these blood clots by cross-linking them.
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Figure 1. Blood Coagulation Cascade |
Fibrinogen was first isolated from horse plasma by Hammarsten in 1876, although an inactive precursor to fibrin was proposed to exist as early as 1859 by Deni de Commercy. Fibrinogen can undergo a remarkable transformation from soluble monomers (fibrogen) to an insoluble polymer gel (polymerised fibrin).
Fibrinogen is a plasma glycoprotein synthesised in the liver that is essential for haemostasis (stopping blood loss from damaged tissues), wound healing, fibrinolysis, inflammation, angiogenesis, cellular and matrix interactions, and neoplasia. These processes involve the conversion of fibrinogen to fibrin, and often the interaction of fibrin(ogen) to various proteins and cells. People usually carry about 2.5g fibrinogen/L of blood, however, concentrations of fibrogen can increase by as much as 200-400% during times of physiological stress (primarily due to the actions of macrophage-derived interleukin-6).
Fibrinogen is a large, complex glycoprotein composed of three pairs of polypeptides: two Aa, two Bb, and two g. These polypeptides are linked together by 29 disulphide bonds, some of which are depicted in Figure 2 below. The polypeptides are oriented so all six N-terminal ends meet to form the central E domain. Two regions of coiled coil alpha helices stretch out on either side of the E domain, each consisting of one Aa, one Bb and one g polypeptide. Each coiled coil region ends in a globular D domain consisting of the C-terminal ends of Bb and g, as well as part of Aa. The C-terminal end of Aa then protrudes from each D domain as a long strand; these Aa protuberances can interact with each other and with the E domain during fibrin clot cross-linking. Both the E and D domains contain important binding sites for the conversion of fibrinogen to fibrin, for fibrin assembly and cross-linking, and for platelet aggregation. Bound calcium ions are important to help maintain the structure of fibrinogen.
The N-terminal ends of both the Aa and Bb polypeptides are cleaved by thrombin in order to turn soluble fibrinogen into gel-forming fibrin. Once cleaved from fibrinogen, the N-terminal ends are known as fibrinopeptide A (from Aa polypeptide) and fibrinopeptide B (from Bb polypeptide).
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Figure 2. Fibrinogen: TOP – polypeptide organisation of fibrinogen. BOTTOM - domain organisation of fibrinogen. |
In order to form a blood clot, fibrinogen must first be cleaved by thrombin to remove the fibrinopeptides. The removal of fibrinopeptides A and B from the N-terminal ends of Aa and Bb exposes ‘knobs’ on the E domain, which can interact with the ‘holes’ always present on the D domains. Fibrin molecules can link together through the interaction of the E domain on one fibrin molecule to the D domains on four other fibrin molecules, thereby polymerising to form staggered oligomers that build up into protofibrils. As the fibrin oligomers aggregate, these protofibrils continue to lengthen to make long fibres that can wind around one another to make multi-stranded, thick bundles, and which can branch into a 3-dimentional network of entangled fibres, the fibrin clot. The fibrin clot is then stabilised by Factor XIIIa, a transglutaminase, where the zymogen form of Factor XIII is converted to active Factor XIIIa through the action of thrombin (see Figure 1). Factor XIIIa cross-links glutamine residues on one fibrin molecule to the lysine residues on another fibrin molecule by forming strong isopeptide bonds. This cross-linking occurs between the C-terminal ends (Aa protuberances) of the Aa polypeptides, as well as (more slowly) at other sites, such as between the C-terminal ends of g chains. These cross-links help strengthen the fibrin clot, making it more resistant to physical and chemical damage.
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Figure 3. Fibrin Polymerisation and lysis: Pathway of fibrin polymerisation and breakdown. The knobs on the E domain bind to the holes on up to four D domains (grey lines), forming a long, fibrous latticework. The clot is then stabilised through cross-linking. The clot can be degraded, yielding different degradation products if it has been cross-linked. |


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