Mansfield General Election candidates explain why you should vote for them
All five candidates have explained why they should get your support
by Kit SandemanThe General Election candidates standing in Mansfield have set out why people should vote for them, and what they would like to achieve if elected.
Conservative Ben Bradley pulled off a major upset here last time round, gaining a seat which in living memory had only ever been held by Labour.
This time, there are five candidates, two of whom are standing as independents in a heavily Leave-leaning area.
We’ve asked all the candidates standing why people should vote for them.
Ben Bradley, Conservative
I’ve been the Member of Parliament for Mansfield since the 2017 election, when I won an historic victory as the first ever Conservative to win the seat, ending nearly 100 years of Labour representation.
Since entering Parliament I’ve been a vocal campaigner for Brexit and have always voted to leave the EU at the earliest opportunity, backing my constituents who voted 71 percent to leave.
My key local priorities have been town centre regeneration, transport links and education, and I’ve made major progress in all three areas.
I secured an [up to] £25m ‘Town Deal’ to boost Mansfield’s local economy along with a commitment to hundreds of new police officers to keep the town safe, over £20m of Government cash for the A38, A617 and A614 as well as big improvement plans on the Robin Hood Rail line, and a £14bn increase in funding for schools while serving on the Education Select Committee in Parliament.
Sarah Brown, Liberal Democrat
I am an HR Professional who joined the Liberal Democrats in 2013.
I’ve been campaigning for several years to remain in the European Union and am strongly behind the Liberal Democrats policy to revoke Article 50 and stop Brexit.
People who voted remain in Mansfield and across the UK are being ignored by both Labour and the Conservatives who are determined to delivery Brexit at any cost.
Brexit has proved itself to be far from what was promised by Boris Johnson and the leave campaign and will cause chaos up and down our country.
Stephen Harvey, Independent
In common with many previous Mansfield MPs I was a local coal miner, then a Mansfield District Councillor before I became Chairman of Mansfield District Council.
I’m also one of only two candidates that actually live in Mansfield.
I’ve consistently campaigned for the delivery of Brexit and am ashamed of our current Parliamentarians.
I have a strong record of defending Mansfield and district taxpayers’ money.
I have directly changed major government policies that have positively affected multi-million pound investments locally.
As the two main parties push more towards the extremities the vast majority of Mansfield and District residents tell me they desperately need a centre ground politician.
This election is not just about Brexit, but also about the NHS, social care, crime, the environment and education all require a huge amount of work.
A vote for an independent means that I can put Mansfield before any political party interests.
Sid Pepper, Independent
Like it or not, the reality is that this election is about Brexit.
All because dishonourable MPs across parliament decided not to honour our democratic vote.
I have stood twice before on a Brexit platform, to see my core voters ‘lend’ their votes in 2017 to the Conservatives, who promised to deliver Brexit.
So I have to stand again, if only to remind voters of the promises made and not delivered by the Tory government.
Again their main pitch is to deliver Brexit. But Johnson’s treaty is not Brexit, so for a second time they are promising something they won’t deliver.
Nationally, I pledge to support the Brexit you voted for and make the Conservatives deliver on this promise.
Locally, I would work to stop the decline of Mansfield, making our market future proof, by moving the stalls undercover – the Old Town Hall, then using the Square for free central parking.
Sonya Ward, Labour
I have lived in Mansfield for more than three decades, and worked across Mansfield, Woodhouse and Warsop as a youth worker, for the NHS and for the Open University.
Mansfield is a great place to live in so many ways, we’ve got wonderful people and great community spirit.
But, I’m concerned nothing has replaced what was lost with the decline of industry.
Wages here are £6,400 below the national average.
Low pay means less disposable income in people’s pockets, and that impacts on our town centres and marketplaces.
It’s hard for young people to find good quality employment here, but under a Labour government, with a new focus on manufacturing in Britain, there will be new opportunities.
We need to be able to look forward with hope, and we can only do that with a government and an MP who will fight for investment not further cuts.
Mansfield was once a thriving district, and it can be again. Back me to back Mansfield.


linear-algebra-js is an optimized linear algebra library in pure Javascript. It supports both sparse and dense matrices, with routines to compute Cholesky, LU, and QR factorizations.
linear-algebra-js is implemented in asm.js to obtain the best possible performance for a Javascript program, and was compiled from a wrapper around the C++ library Eigen with emscripten. Future updates will compile the more optimized sparse matrix library Suitesparse to asm.js.
Detailed documentation and unit tests can be found in the docs and tests directories of this repository.
// solve the linear system Ax = b, where A is a square sparse matrix
let A = SparseMatrix.identity(5, 5);
let b = DenseMatrix.ones(5, 1);
let lu = A.lu();
let x = lu.solveSquare(b);
b.scaleBy(5);
x = lu.solveSquare(b); // factorization is reused
git clone https://github.com/rohan-sawhney/linear-algebra-js.git


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java.lang.Object | +--DataStructures.Sort
A class that contains several sorting routines, implemented as static methods. Arrays are rearranged with smallest item first, using compareTo.
| Constructor Summary | |
Sort()
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| Method Summary | |
static void |
heapsort(Comparable[] a)
Standard heapsort. |
static void |
insertionSort(Comparable[] a)
Simple insertion sort. |
static void |
main(java.lang.String[] args)
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static void |
mergeSort(Comparable[] a)
Mergesort algorithm. |
static void |
quickSelect(Comparable[] a,
int k)
Quick selection algorithm. |
static void |
quicksort(Comparable[] a)
Quicksort algorithm. |
static void |
shellsort(Comparable[] a)
Shellsort, using Shell's (poor) increments. |
static void |
swapReferences(java.lang.Object[] a,
int index1,
int index2)
Method to swap to elements in an array. |
| Methods inherited from class java.lang.Object |
clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait |
| Constructor Detail |
public Sort()
| Method Detail |
public static void insertionSort(Comparable[] a)
a
- an array of Comparable items.
public static void shellsort(Comparable[] a)
a
- an array of Comparable items.
public static void heapsort(Comparable[] a)
a
- an array of Comparable items.
public static void mergeSort(Comparable[] a)
a
- an array of Comparable items.
public static void quicksort(Comparable[] a)
a
- an array of Comparable items.
public static final void swapReferences(java.lang.Object[] a, int index1, int index2)
a
- an array of objects.
index1
- the index of the first object.
index2
- the index of the second object.
public static void quickSelect(Comparable[] a, int k)
a
- an array of Comparable items.
k
- the desired rank (1 is minimum) in the entire array.
public static void main(java.lang.String[] args)
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| SUMMARY: INNER | FIELD | CONSTR | METHOD | DETAIL: FIELD | CONSTR | METHOD |


{% load i18n %} {% blocktrans %}
Again, please accept our apologies for any inconvenience that we cased you.
If you would like to change your feedback or reconsider your out out decision you can do that anytime.


This map is to show how many states aren't involved in the Pink Tax. The states that are marked are the ones that dont tax feminine products. The states that arent marked are the ones that tax feminine products.


List all Reports for an Institute or Center for a particular year
All Annual Reports for NIMH for reporting year 2007
147 Annual Reports
Investigator-Initiated Project
1.
MH000274 (2007) Methods In Mass Spectrometry
Sanford P. Markey, PhD
Mass spectrometric methods for the analysis of protein structures are being improved, applied and tested in independent and collaborative research projects in proteomics. Projects in separation methods, derivatization chemistry, and data processing are in progress. In the past year, progress on Mass ...
2.
MH000279 (2007) Proteomics in neurotoxicology
Sanford P. Markey, PhD
We are applying proteomic methodology to unresolved problems in neuropathologic diseases. In the past year, progress has been made in studies on the postsynaptic density (in press), on Huntingtons disease-related proteins (in review), on Parkinson disease-related proteins (in preparation), and on th ...
3.
MH000332 (2007) Genetic Animal Models for the Study of Serotonin Function and Behavior
Dennis L Murphy, MD
These SERT +/- and -/- mice have gene-proportionate increases in extracellular fluid serotonin (5-HT) concentrations. i.e., 5- or 9-fold excesses respectively over +/+ mice, with the SERT deficiency present since conception. At the same time, the SERT -/- mice have a 50% deficit of intracellular, re ...
4.
MH000336 (2007) The Genetics Of Obsessive Compulsive Disorder
Dennis L Murphy, MD
Our particular disease focus has been OCD for the past two decades. However, because OCD, like other anxiety/depression disorders exhibits high comorbidity with multiple disorders, comorbidity of neuropsychiatric disorders itself has been an additional special focus in consideration of our gene e e ...
5.
MH000478 (2007) Neural Mechanisms Of Stimulus Memory And Habit Formation
Mortimer Mishkin, PhD
(1) The essential circuit for both item and associative stimulus recognition in any given sensory modality (or across modalities) consists of the relevant cortical sensory processing stream(s), the medial temporal periallocortex (i.e. parahippocampal, perirhinal, and entorhinal cortices), the ventro ...
6.
MH000672 (2007) Social Psychological Correlates Of Occupational Conditions
Carmi Schooler, PhD
This project centers on analyses of an extensive SSES designed longitudinal survey of a nationally representative U.S. sample, interviewed in 1964, 1974 and 1994. We test hypotheses about how, as one grows older, social-structurally determined environmental conditions, such as complexity, continue t ...
7.
MH000889 (2007) Studies On Protein Synthesis And Long-Term Adaptive Responses in the CNS
Carolyn E Beebe, PhD
In the current year work progressed in the following two areas:
1) Modification of the L-1-C-14leucine method for use in man with L-1-C-11leucine and positron emission tomography (PET). The ability to measure rCPS with PET will provide us with a new tool to investigate the human brain and its reg ...
8.
MH001039 (2007) Sphingolipid Signaling
Sheldon Milstien, PhD
Sphingosine-1-phosphate (S1P) is a potent lipid mediator that regulates many vital biological processes, including cell growth, death, and differentiation. S1P has been shown to play important roles in normal and patho-physiological processes, including cancer, asthma, allergic responses, hearing ...
9.
MH001090 (2007) Studies Of Central Nervous System Functional Anatomy
Miles Herkenham, PhD
Our approach is to clarify the normal and pathophysiological roles of immune system molecules in the brain, to identify cellular and molecular components induced by immunological challenges, seizures, and behavioral manipulations, and to further characterize the responses at molecular, anatomical, a ...
10.
MH001092 (2007) The Frontal Lobes and Motor Skills and Planning
Steven P Wise, PhD
The vertebrate brain evolved to control movements and thereby achieve biological goals, including procreation, harm avoidance, ingestion of essentials, exploration, and energy economics. To cope with changing conditions, early vertebrates developed, and their descendants inherited, the ability to ex ...
11.
MH001101 (2007) Cortical Mechanisms Of Auditory Perception And Memory
Mortimer Mishkin, PhD
(1)The cortical auditory system is far more extensive than expected, as it includes not only the entire superior temporal gyrus but also large portions of the parietal, prefrontal, and limbic lobes. Several of these areas overlap with previously identified visual areas, suggesting that the auditory ...
12.
MH002032 (2007) Neural Coding Of Visual Stimuli
Barry J Richmond, MD
The number of spikes emitted by a neuron varies with experimental condition, and all that we know about how neurons work indicates that these spike trains are responsible for carrying information quickly over distances from several millimeters to many decimeters (e.g., into the spinal cord). To desc ...
13.
MH002035 (2007) Functional Anatomy Of Perceptual And Memory Systems In The Primate Brain
Leslie G Ungerleider, PhD
A typical scene contains many different objects that compete for neural representation due to the limited processing capacity of the visual system. At the neural level, competition among multiple stimuli is evidenced by the mutual suppression of their visually evoked responses and occurs most strong ...
14.
MH002036 (2007) Neural Mechanisms For Attention And Memory In The Extrastriate Cortex
Richard C Saunders, PhD; Leslie G Ungerleider, PhD
Disorders of perception, attention, and memory frequently accompany the major mental diseases. To understand the neural mechanisms of these mental processes, we are recording the activity of neurons in the extrastriate and prefrontal cortex of monkeys engaged in tasks requiring stimulus discriminati ...
15.
MH002039 (2007) Pharmacology Of Stimulus Memory And Habit Formation
Mortimer Mishkin, PhD
(1) A cholinergic contribution to one-trial visual recognition in the monkey was first demonstrated in studies showing that this function could be enhanced and impaired, respectively, by systemic administration of the cholinergic agonist, physostigmine, and the cholinergic antagonist, scopolamine. L ...
16.
MH002177 (2007) Behavioral Functions of Neuropeptides
Jacqueline N Crawley, PhD
Our laboratory is engaged in investigating the behavioral concomitants of the inhibitory effects of galanin. The neuropeptide galanin is localized in the hippocampus, coexists with acetylcholine in the rat septohippocampal pathway, coexists with norepinephrine in the locus coeruleus, inhibits the ...
17.
MH002179 (2007) Animal Models Of Neuropsychiatric Disorders
Jacqueline N Crawley, PhD
Relevant to our research interests in animal models of neuropsychiatric diseases, our Laboratory of Behavioral Neuroscience investigates the behavioral phenotypes of transgenic and knockout mice with mutations in genes expressed in brain pathways involved in neuropsychiatric disorders. We developed ...
18.
MH002228 (2007) Genetic Neurobiology Of Drosophila
Howard A. Nash, MD, PhD
In a screen for genes that influence the sensitivity of fruit flies to the volatile anesthetic halothane, we turned up a mutation in the inaF locus. From work of others, this gene was known to have strong effects on visual signaling through its effect on TRP channels, the principal source of light-i ...
19.
MH002240 (2007) Neurobiology Of Disruptive Behavior Disorders
Judith L Rapoport, MD
For our initial sample, children with Attention-Deficit/Hyperactivity Disorder (ADHD) participated in double-blind placebo-controlled randomized trails of stimulants while undergoing anatomic imaging with magnetic resonance imaging (MRI). The children are now being followed, with repeated clinical a ...
20.
MH002344 (2007) Neuropsychiatric Disorders--protein Structure/activity Studies
Brian M Martin, PhD
The unambiguous identification of proteins/peptides is crucial for the definition of the proteome. Using ProteinChip Array technology (SELDI) we have developed experimental protocols and probed test conditions required for protein identification on ProteinChip Arrays. We are able to directly diges ...
21.
MH002386 (2007) Chemical Coding Of Neurotransmission
Lee E Eiden, PhD
The Section on Molecular Neuroscience studies slow (metabotropic) transmission in the nervous system, to identify novel molecular components underlying cellular plasticity following synaptic activity and slow transmitter release and post-synaptic action. The neuropeptide PACAP, acting through its ...
22.
MH002399 (2007) Postmortem Brain Tissue Examination in Neuropsychiatric Disorders
Joel Kleinman, MD, PhD
Regarding normal human brain development, our group examined pre- and post-synaptic markers of the dopamine (DA) system in postmortem tissue across the lifespan (2 months to 86 years). We measured levels of tyrosine hydroxylase (TH), the rate limiting enzyme in DA biosynthesis and measured the three ...
23.
MH002468 (2007) Mechanisms Of Action Of Psychoactive Drugs
De Maw Chuang, PhD
The precise mechanisms underlying the clinical efficacy of lithium and VPA in treating bipolar disorder remain to be defined. We first investigated the neuroprotective effects of lithium against excitotoxicity elicited by glutamate, a major excitatory amino acid neurotransmitter involved in the syn ...
24.
MH002497 (2007) Functional Organization Of The Basal Ganglia
Charles R Gerfen, PhD
Work during the fiscal year extended our prior research on the function of the basal ganglia in animal models of neurologic disorders. Our work was the first to demonstrate that there is an abnormal coupling of Drd1a dopamine receptors to activation of Extracellular Receptor Kinase (ERK1/2) in an a ...
25.
MH002498 (2007) Regulation Of Gene Expression In The Brain
Walter Scott Young, MD, PhD
Vasopressin (Avp) and oxytocin (Oxt) are neurohormones that are best known for their peripheral actions in regulating salt and water balance, blood pressure, lactation and parturition. However, numerous pharmacological studies have implicated these hormones in various behaviors as well, including ...
26.
MH002537 (2007) Psychobiology And Treatment Of Perimenopausal Mood Disorders
Peter J Schmidt, MD
Findings to date: 1) a significant improvement in measures of depression and libido after DHEA administration in men and women with midlife-related major and minor depression; 2) neither short term (six week) nor long term (six months-one year) administration of DHEA significantly altered measures o ...
27.
MH002569 (2007) Mathematical And Statistical Analysis Techniques For In Vivo Imaging Studies
Kathleen Colette Schmidt, MA; Carolyn E Beebe, PhD
(1) We have validated a method for quantitative determination of regional rates of cerebral protein synthesis (rCPS) with C-11 leucine and PET (see project MH000889). The method uses a kinetic modeling approach to estimate lamda, the fraction of the precursor pool for protein synthesis derived fro ...
28.
MH002581 (2007) Childhood Onset Schizophrenia
Judith L Rapoport, MD
Children and adolescents meeting DSM-IV criteria for schizophrenia are being obtained through vigorous national recruiting. Ninety subjects and their families have participated to date in this study of the phenomenology, neurobiology and pharmacologic response of childhood onset schizophrenia. Over ...
29.
MH002585 (2007) Role of Neuroendocrine Stress Response in Inflammatory and Behavioral Illness.
Esther M Sternberg, MD
The research of the Section on Neuroendocrine Immunology and Behavior (SNIB) focuses on mechanisms of glucocorticoid resistance in inflammatory, infectious and mood disorders, using repression of the glucocorticoid receptor (GR) and other nuclear hormone receptors (NHRs) by bacterial toxins as a mod ...
30.
MH002588 (2007) The Functional Neuroanatomy Of Memory Systems In The Human Brain
Alex Martin, PhD
Our research program is concerned with elucidating the neural basis of human memory function. During the past year, we have continued to concentrate on three domains of memory. The first domain focuses on semantic memory, the part of long-term memory composed of general information, such as facts, i ...
31.
MH002592 (2007) Viral And Cellular Factors Governing Efficient Gene Delivery
Maribeth V Eiden, PhD
Several viral diseases have emerged in the late 20th and early 21st centuries. This has created an urgent need to understand the mechanisms of viral entry underlying host range and pathogenicity, and a unique opportunity to exploit this knowledge to create new types of viral vectors that target ther ...
32.
MH002619 (2007) Neural Mechanisms Of Motivation And Reward
Barry J Richmond, MD
The intensity or vigor of goal-directed behavior is a correlate of the motivation underlying it, and, therefore, motivation can be inferred by monitoring the performance of goal-directed behavior. To study motivated behavior in monkeys, we use a task in which monkeys must perform some work, in this ...
33.
MH002629 (2007) HIV Nef Function and Early Events in Macrophage and Microglia Infection
Jon W. Marsh, PhD
The objective of this study is to elucidate the intracellular interactions of the HIV regulatory protein Nef with host cell activities. Early in the HIV-1 infection of CD4 T cells this retrovirus expresses regulatory proteins, with the Nef transcript representing nearly 80% of total viral mRNA. In v ...
34.
MH002652 (2007) Imaging of Neuropsychiatric Disorders with Developmental and Genetic Mechanisms
Karen F Berman, MD
Our group used functional neuroimaging to determine local neuronal activity in patients with schizophrenia and other neuropsychiatric disorders during performance of working memory and abstract reasoning tasks as well as during performance of matched sensorimotor control tests and other contrast tas ...
35.
MH002659 (2007) The Neurobiology Of Major Depression
Philip William Gold, MD
For over a decade, we have conducted a series of studies exploring the physiologic and pathophysiologic implications of CRH utilizing acute and chronic antalarmin administration in rodents and non-human primates. We extended our prior work showing that antalarmin acutely suppresses key behavioral a ...
36.
MH002666 (2007) Evaluation And Treatment Of Obsessive Compulsive And Related Disorders
Susan Elizabeth Swedo, MD
There are two projects within this research portfolio. The first is a longitudinal study of children in the PANDAS subgroup (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections) and the second is a clinical trial of riluzole - a glutamate antagonist with so ...
37.
MH002673 (2007) Migration For Work, Mental Health And AIDS In Mali
Carmi Schooler, PhD
In collaboration with the Centre Regional de Medecine Traditionnelle in Bandiagara Mali, this longitudinal project investigates how migration for work and other socio-environmental factors affect psychological functioning, mental and physical health as well as the nature of AIDS-related attitudes an ...
38.
MH002685 (2007) Peptide Receptor Systems
Theodore B Usdin, MD, PhD
A current major focus of the laboratory is investigation of the physiological function of the neuropeptide tuberoinfundibular peptide of 39 residues (TIP39) and its receptor the parathyroid hormone 2 (PTH2) receptor, which were discovered in this laboratory several years ago. Using site directed mu ...
39.
MH002698 (2007) Apoptosis In Neurons
De Maw Chuang, PhD
We have used primary cultures of rat CNS neurons and neurally related cell lines as a model to study molecular mechanisms underlying neuronal apoptosis. We found that glyceraldehyde-3-phospahate dehydrogenase (GAPDH), a glycolytic enzyme and traditionally thought to be a house-keeping gene, is over ...
40.
MH002704 (2007) The National Collaborative Study of Early Psychosis and Suicide (NCSEPS)
Kathleen R Merikangas, PhD
Although analyses of these data are ongoing, a number of interesting findings have emerged. Some of this work was completed in the Neuropsychiatry Branch, but much of it has continued in our Section, and we have several promising avenues for future research. When the project was transferred to my gr ...
41.
MH002716 (2007) MRI Studies of Brain Function and Metabolism
Daniel R. Weinberger, MD
Interesting findings have emerged from our studies this year. First, we began to tackle the problem of ill-defined phenotypes then we examined the contribution of several potentially functional variants in the gene catechol-o-methyltransferase (COMT) and haplotypes to the risk of schizophrenia (SCZ) ...
42.
MH002717 (2007) Neuroimaging of Brain Circuits and Neurogenetic Mechanisms in Normal Cognition
Karen F Berman, MD
We have used neuroimaging to explore the effects in the brain of allelic variation in the catecholO-methyltransferase gene (COMT), which has been identified as a gene of interest for schizophrenia. It is well-established that, particularly in prefrontal cortex, COMT is prime determinant of dopamine ...
43.
MH002734 (2007) Genetic Basis Of Cortical Malfunction In Schizophrenia
Daniel R. Weinberger, MD
Cortical dysfunction has been implicated in the pathophysiology of schizophrenia (SCZ). Decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD67), encoded by GAD1, is found in SCZ postmortem brain. We report evidence of distorted transmission ...
44.
MH002736 (2007) Neural Substrates Of Stimulus Recognition And Association Memory
Elisabeth Adams Murray, PhD
The perirhinal cortex receives inputs from both unimodal sensory areas such as area TE (which plays a key role in color and form vision) and the caudal, granular insular cortex (which plays a key role in touch), as well as from multimodal regions including the cingulate cortex and orbital frontal co ...
45.
MH002747 (2007) Tolerance In Organ Transplantation And Autoimmune Disease By T Cell Immunotoxin
David M. Neville, MD
The general aim of this project is to study the effects of immunotoxin induced transient T-cell depletion on the modulation of T cells from immunization responses towards tolerizing responses, and to use this knowledge for the experimental and clinical treatment of T cell driven autoimmune diseases, ...
46.
MH002762 (2007) Role Of Neuropeptides And Biogenic Amines In Stress and Brain Inflammation
Juan M. Saavedra, MD
Our laboratory studies the central mechanisms leading to anxiety, depression, stress-related illnesses and inflammatory diseases of the brain, with the goal to develop novel therapeutic strategies for these diseases. We initially found that the hormone and brain modulator Angiotensin II (Ang II), t ...
47.
MH002768 (2007) Subcellular Compartmentilization of Neuronal Gene Expression
Barry Bernard Kaplan, PhD
Axons and nerve terminals are unique subcellular structures of the neuron that play a critical role in the development and maintenance of neural connectivity. One of the central tenets in neuroscience is that the protein constituents of these distal neuronal compartments are synthesized in the nerve ...
48.
MH002778 (2007) The Phenomenology And Neurophysiology Of Juvenile Bipolar Disorder
Ellen Leibenluft, MD
This purpose of this study to identify brain mechanisms mediating the symptoms of bipolar disorder (BD)in children and adolescents. To do this, patients and controls complete standardized behavioral paradigms designed to assess responses to emotional stimuli, such as reward and punishment, or faces ...
49.
MH002780 (2007) Fmri Studies Of Emotional Development
Daniel Pine, MD
The goal of this set of projects is to use functional magnetic resonance imaging (fMRI) to compare the degree to which brain regions of adolescents and adults are engaged by tasks involving processing of emotionally salient stimuli. Based on developmental continuities in the relevant psychological ...
50.
MH002781 (2007) fMRI Studies Of Pediatric Mood And Anxiety Disorders
Daniel Pine, MD
Through a series of three protocols, we are using functional magnetic resonance imaging (fMRI) to examine the effects of pharmacologic treatment on neurocognitive and neurochemical correlates of pediatric mood and anxiety disorders. In one aspect of this project, we are attempting to document defic ...
51.
MH002782 (2007) Fmri Studies Of Risk For Mood And Anxiety Disorders In Children
Daniel Pine, MD
In this project, our group is examining biological aspects of risk for mood and anxiety disorders in children. This project encompasses work that is being implemented in three protocols. In one protocol, we are examining the degree to which traumatic experiences predict perturbations in brain func ...
52.
MH002783 (2007) Functional MRI Method Development
Peter A Bandettini, BS, PhD
The FIM section is continuing an effort to develop more robust, informative, and quantitative methods for mapping human brain function in both the activated state and during resting state. To summarize, the following were among the highlights, organized by research project corresponding to the liste ...
53.
MH002784 (2007) Neurogenesis In The Adult Brain
Heather A Cameron, PhD
To study the regulation of adult neurogenesis and its relationship to behavior, we use rodents, mice and rats, which show features of adult neurogenesis nearly identical to those in primates, including regulation by stress and stress hormones. This year we published an investigation of the inhibitio ...
54.
MH002785 (2007) Basic Cognitive/neuropsychological Processes And Their Environmental Modulation
Carmi Schooler, PhD
The application of the SSES SEM-based analytic approach to neuroscience primarily involves collaborating with neuroscientists in developing and carrying out analyses testing their hypotheses and elucidating their data when more traditional forms of analysis are inadequate. One such longstanding coll ...
55.
MH002786 (2007) The Characterization And Treatment Of Children With Severe Mood Dysregulation
Ellen Leibenluft, MD
Recently, researchers and clinicians have focused increased attention on a group of children with severe mood and behavioral dysregulation (SMD). These children are characterized by impairing symptoms that include abnormal baseline mood (i.e. irritability, anger, and/or sadness), hyperarousal (e.g. ...
56.
MH002788 (2007) Serotonin Function and Receptor Imaging In Mood and Anxiety Disorders
Wayne Drevets, MD
A variety of evidence suggests serotonin 1A (5-HT1A) receptor function is abnormal in panic disorder (PD), posttraumatic stress disorder (PTSD), and depression. This project investigates the pharmacological basis for 5-HT1A abnormalities in vivo by applying positron emission tomography (PET) and the ...
57.
MH002789 (2007) Serotonin And Benzodiazepin Receptor Imaging In Panic Disosrder And Ptsd
Wayne Drevets, MD
Evidence suggests that serotonin1A (5-HT1A) receptor and benzodiazepine (BZD) receptor function is abnormal in panic disorder (PD), postraumatic stress disorder (PTSD), and depression (MDD). Evidence arguing for a role of BZD/GABA receptor dysfunction in anxiety disorders comes from studies showing ...
58.
MH002790 (2007) Structural Brain Abnormalities In Depression
Wayne Drevets, MD
The hippocampus, amygdala, and ventral anterior cingulate are each implicated in the pathophysiology of mood disorders. The volume of the subiculum of the hippocampus is abnormally decreased in major depressive disorder (MDD) and bipolar disorder. Subtle decreases in hippocampal volume were previous ...
59.
MH002791 (2007) Effect Of Treatment & Course On Anterior Cingulate Volume In Mood Disorders
Wayne Drevets, MD
Neuroimaging and neuropathological studies of bipolar disorder (BD) have provided substantial evidence that brain structures that normally modulate emotional, autonomic and neuroendocrine responses to stress and emotionally provocative stimuli contain abnormal reductions in grey matter volume, synap ...
60.
MH002792 (2007) Functional Neuroimaging In Unipolar And Bipolar Depressed Patients
Wayne Drevets, MD
During the depressed phase of major depressive disorder and bipolar disorder, glucose metabolism is abnormally elevated in the amygdala, a brain structure that is critically involved in associating experiential stimuli with emotional significance and in organizing the endocrine, autonomic and behavi ...
61.
MH002793 (2007) PET Radiopharmaceutical Sciences
Victor W Pike, PhD
The Molecular Imaging Branch (MIB) mainly aims to exploit positron emission tomography (PET) as a radiotracer imaging technique for investigating neuropsychiatric disorders, such as depression, schizophrenia and Alzheimer's disease. Fundamental to the mission of the MIB is the development of novel r ...
62.
MH002794 (2007) Pediatric Brain Imaging
Jay Giedd, MD
The foundations of risk for many psychiatric disorders, including those with adult onset, are increasingly understood as arising from anomalies of neurodevelopment. In this longitudinal study (with participants returning at approximately two-year intervals) we combine brain imaging information with ...
63.
MH002795 (2007) Preclinical Evaluation Of PET Radiotracers
Robert Innis, MD
This laboratory has made progress in two general areas: programmatic and specific radioligands.
PROGRAMMATIC.
1) The Biomarkers Consortium approved the proposal of Victor Pike and me to develop further a PET radioligand for inflammation. The Biomarkers Consortium is a collaboration of NIH, FDA, a ...
64.
MH002797 (2007) Neuronal avalanches in the neocortex
Dietmar Plenz, PhD
Research in the Section on Critical Brain Dynamics is primarily concerned with functions of the neocortex, which is involved in higher cognitive functions e.g. executive decisions and working memory. Our work focuses on the function of the fast neurotransmitters glutamate and GABA and the neuromodu ...
65.
MH002798 (2007) The Psychophysiology Of Fear And Anxiety
Christian Grillon, PhD
Although converging evidence from different levels of analyses supports the conception of fear and anxiety as distinct phenomena, little is known about the distinguishing features of these two aversive states. Both fear and anxiety are responses to threat. However, while fear is a phasic response to ...
66.
MH002800 (2007) Identifying Neural Substrates of Behavior in Drosophila Melanogaster
Benjamin H White, PhD
The goal of this research program is to exploit, and further develop, techniques for manipulating neural activity to identify the brain circuits underlying specific behaviors. Using the Gal4-UAS gene targeting system of Drosophila melanogaster to drive the expression of genes whose products inhibit ...
67.
MH002803 (2007) Magnetic Resonance Spectroscopy and Imaging Studies of Brain Functions
Jun Shen, PhD
The overall goal of my group is to develop advanced magnetic resonance spectroscopy and imaging techniques and to apply them and other complementary methods to studying brain metabolism and neurotransmission. Magnetic resonance spectroscopy allows measurement of neurotransmission of glutamate and GA ...
68.
MH002804 (2007) Family Study of Affective and Anxiety Spectrum Disorders
Kathleen R Merikangas, PhD
The chief goal of this study is to identify the endophenotypes of the spectrum of mood disorders using the methods of genetic epidemiology, developmental psychopathology and clinical psychiatry/psychology. The major research questions focus on the specificity of familial transmission of the mood dis ...
69.
MH002806 (2007) National Comorbidity Survey - Replication (NCS-R)
Kathleen R Merikangas, PhD
The key objective of this study is to collect the first nationally representative data on prevalences and correlates of DSM-IV MDD from the recently completed National Comorbidity Survey Replication (NCS-R). The study design is a direct interview household survey of a probability household survey of ...
70.
MH002807 (2007) Zurich Cohort Study of Young Adults
Kathleen R Merikangas, PhD
The Zurich Cohort Study is a prospective longitudinal study of a cohort of young adults from Zurich, Switzerland, who were followed from the ages of 20-40 in order to estimate the prevalence, incidence, impairment, treatment patterns and stability of the major mental disorders. This study assessed a ...
71.
MH002808 (2007) National Comorbidity Survey - Adolescent (NCS-A)
Kathleen R Merikangas, PhD
The Adolescent Component of the National Comorbidity Study (NCS-A) is a combined probability and school-based multi-ethnic sample of 10,000 US adolescents. Dr. David Offord and his team at McMaster University and our research group at Yale adapted the adult diagnostic interview for adolescents. This ...
72.
MH002810 (2007) Mapping genes that contribute to bipolar disorder
Francis Joseph McMahon, MD
Bipolar Disorder is a common, often severe mental illness. Family, twin, and adoption studies have demonstrated that genes are the major determinant of individual risk for the disorder, but as in other common disorders, the identification of these genes has proven to be a significant challenge. In c ...
73.
MH002811 (2007) Muscarinic Cholinergic Receptor Imaging in Depression
Wayne Drevets, MD
Several paths of evidence converge in implicating a role for the cholinergic system in the pathophysiology of affective illness. In both unipolar depressed and euthymic bipolar subjects, cholinomimetic drugs (i.e., muscarinic agonists, acetylcholinesterase inhibitors) exacerbate depressive signs and ...
74.
MH002812 (2007) Functional MRI Study of Brain Mechanisms Mediating Anhedonia in Major Depression
Wayne Drevets, MD
Anhedonia has been one of the two key diagnostic criteria for major depressive disorder (MDD) since the publication of The Diagnostic and Statistical Manual of Mental Disorders, Third Edition, yet little is known about its neural substrates. Neuroimaging studies have identified numerous brain region ...
75.
MH002813 (2007) Cholinergic Modulation of Cognition and Emotion in Mood Disorders
Maura L Furey, PhD
In addition to pervasive sadness, specific aspects of behavior and cognition are impaired in mood disorders, including selective attention, set-shifting and memory; and there also is evidence that depressed individuals exhibit a mood congruent processing bias whereby they more readily process negati ...
76.
MH002814 (2007) Effects of Hydrocortisone Infusion on Processing of Facially Expressed Emotion
Wayne Drevets, MD
Glucocorticoids influence performance on declarative memory tasks and tasks of memory for emotional information. The cognitive effects of exogenous glucocorticoids depend on dose, the time period between administration and testing, and the time of testing within the diurnal pattern of cortisol secre ...
77.
MH002817 (2007) Tryptophan Depletion in Remitted Depressed Patients
Wayne Drevets, MD
Major depressive disorder (MDD) has been associated with abnormally reduced function of central serotonergic systems by various types of evidence. One instructive paradigm for investigating the relationship between serotonergic function and depression has involved the mood response to tryptophan dep ...
78.
MH002820 (2007) Antiglucocorticoid Therapy in Bipolar Depression with Mifepristone (RU486)
Husseini K Manji, MD
Patients with bipolar depression often have indices of hypercortisolism, which potentially contribute to central nervous system dysfunction responsible for the cognitive and affective abnormalities in bipolar disorder. Recent data reveal that mifepristone is capable of ameliorating the mood and thou ...
79.
MH002825 (2007) Role of Rhythmic Oscillations in Neuronal Plasticity
Alexei Y Morozov, PhD
Various types of rhythmic oscillations in the brain are associated with specific stages of sleep and wakefulness and also correlate with degree of arousal. It is hypothesized that some of those rhythms may be required for the acquisition and consolidation of memories and affect mental state, however ...
80.
MH002826 (2007) Control of Fear/Defensive Behavior by Brain Derived Neurotrophic Factor
Alexei Y Morozov, PhD
Multiple studies suggest that interaction between the higher brain structures like cortex and hippocampus on one side, and a so called defensive circuitry (which includes amygdala, hypothalamus and periaqueductal grey), on the other side, determine fear/defensive behavior. Moreover, changes in such ...
81.
MH002828 (2007) Antidepressant Efficacy of an Antiglutamatergic Agent in Bipolar Depression
Carlos Alberto Zarate, MD; Husseini K Manji, MD
The treatments for acute unipolar depression have been extensively researched. However, despite the availability of a wide range of antidepressant drugs, clinical trials indicate that 30% to 40% of depressed patients fail to respond to first-line antidepressant treatment, despite adequate dosage, du ...
82.
MH002830 (2007) Efficacy of the Protein Kinase C Inhibitor Tamoxifen in Treatment of Acute Mania
Carlos Alberto Zarate, MD; Husseini K Manji, MD
Bipolar Disorder (BD) is a common, severe, chronic and often life-threatening illness. The discovery of lithium's efficacy as a mood-stabilizing agent has since revolutionized the treatment of patients with BD. Elucidation of the mechanism(s) by which lithium stabilizes an underlying dysregulation o ...
83.
MH002831 (2007) AMPA Receptor Subunit GluR1 Synaptic Expression and Trafficking
Husseini K Manji, MD
A growing body of data shows that the AMPA subtype of glutamate receptors play a major role in regulating short and long term forms of synaptic plasticity. Furthermore, it is now clear that regulation of plasticity occurs predominantly by regulating the trafficking of AMPA receptor subunits, and th ...
84.
MH002832 (2007) Microarray Studies Identify the Anti-Apoptotic, GR Chap. Protein, BAG-1 in BPD
Husseini K Manji, MD
The mood stabilizers lithium and valproate are both effective in the treatment of bipolar disorder; however, their therapeutic mechanisms remain unclear. Because of the delayed onset of clinical efficacy (days to weeks), it has been proposed that adaptive changes in gene expression, rather than init ...
85.
MH002833 (2007) Investigation of Mitochondrial Function in Bipolar Disorder
Husseini K Manji, MD
Mood disorders have traditionally been considered to be neurochemical disorders, but new evidence demonstrates impairments of structural plasticity and cellular resilience in the central nervous system. Recent preclinical and clinical studies have shown that signaling pathways involved in regulating ...
86.
MH002835 (2007) Neuronal-Glial Interaction in the Treatment of Bipolar Disorder
Husseini K Manji, MD
There is now compelling evidence that radial glial cells have the potential, not only to guide newly born neurons, but also to self-renew and to generate both neurons and astrocytes. Recent data has also shown that astrocytes increase the number of mature, functional synapses on central nervous sys ...
87.
MH002838 (2007) Neurophysiology of Visual Perception
David A Leopold, PhD
Studying the neural basis of visual perception is inherently challenging because of the dissimilar nature of psychological and biological measurements. For the psychologist, it is possible to speak precisely about subjective quantities in vision such as brightness or depth, yet psychophysical metho ...
88.
MH002839 (2007) Studies of GIRK2 Gene Expression in the Down Syndrome Mouse Cerebellum
David M Jacobowitz, PhD
1. Down syndrome (DS) arises from the presence of three copies of chromosome (Chr.) 21. Fine motor learning deficits found in DS from childhood to adulthood result from expression of extra genes on Chr. 21, however, it remains unclear which if any of these genes are the specific causes of the cognit ...
89.
MH002840 (2007) Glucocorticoid Receptors (GR) in Mitochondria: The Role in Chronic Stress
Husseini K Manji, MD
Chronic stress has been shown to be associated clinically with formation of depression in patients and hormones are known to mediate certain clinical manifestations of mood disorders. Chronic restraint stress induces a morphological reorganization in the areas of rodent brain, effects which are als ...
90.
 However, it is unclear if lithiums inhibition of GSK-3 is relevant for its antimanic and antidepressant effectiveness. We are utilizing biochemical, cellular, histochemical, genomic, and beh ...
91.
MH002842 (2007) A Collaborative Genomic Study of Bipolar Disorder
Francis Joseph McMahon, MD
Since 1988 the NIMH Genetics Initiative has supported a national resource for the study of bipolar disorder (BP). This extension of the national genetic resource will include a sample of 5000 unrelated BP probands and 2000 parents for case-control, and family-based association studies. Control sampl ...
92.
MH002843 (2007) Genetic Linkage and Association in Bipolar Disorder
Francis Joseph McMahon, MD
This three-site collaboration has developed a bipolar disorder family resource that has proven to be uniquely valuable in testing clinically based hypotheses about the genetic heterogeneity of the illness. We are ascertaining and assessing 112 additional nuclear families with a bipolar I proband and ...
93.
MH002844 (2007) Genetic Determinants of Antidepressant Response in the STAR*D Cohort
Francis Joseph McMahon, MD
Strong evidence from family and twin studies demonstrates that major depressive disorder (MDD) is heritable, yet there has been limited progress in identifying the actual genes involved. A separate, perhaps overlapping set of genes is expected to play a role in individual variation in treatment resp ...
94.
MH002845 (2007) In vivo Analysis of Mouse in which Genetic Mutation is Targeted to CA3 Cells
Kazutoshi Nakazawa, MD, PhD
The hippocampus is composed of anatomically heterogeneous subregions, including CA1, CA3, dentate gyrus and subiculum. A major feature of CA3 is its recurrent collateral circuitry, by which the CA3 pyramidal cells make excitatory synaptic contacts with each other. This feature is unique to this subr ...
95.
MH002846 (2007) Generation and Analysis of Genetic Protein Synthesis Knockdown Mice
Kazutoshi Nakazawa, MD, PhD
It is well known that when animals are treated with protein synthesis inhibitors, such as anisomycin, which stop the production of proteins in the animals brains, these animals have long-term memory impairments. Furthermore, certain types of memories are dependent on the hippocampal protein synthesi ...
96.
MH002848 (2007) Family Study of African Americans & Vuln. Factors Among Migrant Puerto Ricans
Kathleen R Merikangas, PhD
Family Study of African Americans
This project was a five year study of black children ages 8-17 at high and low risk for alcohol-related problems based on a history of parental alcoholism. A prospective design was used to identify the specific disorders for which these children are at heightened v ...
97.
MH002849 (2007) Family Study of Comorbidity of Anxiety Disorders and Substance Use Disorders
Kathleen R Merikangas, PhD
This study examined the familial transmission of anxiety disorders and substance abuse using a combination of the family study/longitudinal high risk paradigms. This study also investigated comorbidity between physical disorders and mood and anxiety disorders. The chief findings reveal specificity o ...
98.
MH002851 (2007) Generalized Anxiety Disorder and Social Anxiety Disorder:
Robert James Richard Blair, PhD
There have been suggestions that the threshold for amygdala activity is lower in individuals with anxiety disorders than in healthy individuals. However, despite its immediate plausibility, there have been relatively few tests of this hypothesis. Specifically, there have been very few explorations ...
99.
MH002852 (2007) Clinical Evaluation of PET Radiotracers
Robert Innis, MD
Examples of our findings include:
1) We evaluated in healthy subjects a promising radioligand to quantify the cannabinoid CB1 (marijuana) receptor in brain. This receptor may be altered in obesity and alcoholism
2) We studied in healthy subjects a promising probe to measure inflammation. In t ...
100.
MH002853 (2007) A pharmacologic strategy to bring about rapid (next day) antidepressants effects
Carlos Alberto Zarate, MD; Husseini K Manji, MD
Sleep deprivation is one of the only interventions that have consistently been demonstrated to produce rapid antidepressant effects. The mechanisms by which sleep deprivation brings about rapid antidepressant effects have not been elucidated. It is noteworthy; however, that recent genomic and proteo ...
101.
MH002854 (2007) In Search Of Protein Markers In Platelets Of People With Bipolar Disorder
David M Jacobowitz, PhD
Background: Depression is considered to be among the most significant causes of disability worldwide. Bipolar depression has been treated with the element Lithium since the late 19th century, although the mechanism of lithium action is still not known. A co-morbid relationship has often been describ ...
102.
MH002855 (2007) Antidepressant Efficacy & Safety of AMPAkine (Org 24448) in Major Dep Disorder
Carlos Alberto Zarate, MD; Husseini K Manji, MD
Depression is a devastating illness that affects approximately 12 to 17% of the population at some point during the lifetime of an individual (Kessler et al 1994). Despite the availability of a wide range of antidepressant drugs, 30% to 40% of patients with major depression fail to respond to first- ...
103.
MH002856 (2007) Comb Dopamine Agonist & Select Serotonin Reuptake Inhibitor f/Trtmt of Depression
Carlos Alberto Zarate, MD; Husseini K Manji, MD
Despite the availability of a wide range of antidepressant drugs, 30% to 40% of patients with major depression fail to respond to first-line antidepressant (e.g., selective serotonin reuptake inhibitors SSRIs) treatment, despite adequate dosage, duration, and compliance. Furthermore, these medicatio ...
104.
MH002857 (2007) Glutamatergic Modulators for Rapid & Sustained Antidepressant Effect
Carlos Alberto Zarate, MD; Husseini K Manji, MD
Bipolar affective disorder (manic-depressive illness) and unipolar depression are common, severe, chronic and often life-threatening illnesses. Impairment in physical and social functioning resulting from depression can be just as severe as other chronic medical illnesses. Recent preclinical and cli ...
105.
MH002859 (2007) Rev-dependent Expression Vector
Jon W. Marsh, PhD
As a provirus, HIV DNA transcription results in a single full-length message, which through splicing events encodes 9 different genes. The switch from early gene expression (fully spliced transcripts) to late gene expression (singly and non-spliced transcript; structural and enzymatic genes) is dep ...
106.
MH002860 (2007) Emotional dysfunction and childhood behavioral disturbance
Robert James Richard Blair, PhD
The goal of this protocol is to investigate the neurocognitive underpinnings of the emotional dysfunction linked to childhood behavioral disturbance; in particular, extreme conduct disorder but also attention deficit and hyperactivity disorder (ADHD). The functional hypotheses that we are testing w ...
107.
MH002862 (2007) The role of serotonin in emotional processing
Robert James Richard Blair, PhD
The goal of this protocol is to use a targeted serotonergic manipulation (tryptophan depletion: ATD) and specific neurocognitive and neuroimaging paradigms to consider the role of serotonin in emotional processing. Our goal was to evaluate claims that serotonin has a role in the effective processin ...
108.
MH002863 (2007) Multimodal Neuroimaging of Gene-Brain Relationships in Williams Syndrome
Karen F Berman, MD
We previously used multimodal neuroimaging to define three fundamental aspects of the brain phenotype in WS that are related to clinical features: 1) Underlying the syndromes cognitive hallmark, visuospatial construction impairment, is a neurostructural anomaly (decreased gray matter volume) and adj ...
109.
MH002864 (2007) Neurobiological Basis for Schizophrenia
Cynthia S Shannon-Weickert, PhD
Using human postmortem brains, our studies focus on postnatal developmental changes. We examined Catechol-o-methyltansferase (COMT) enzyme activity and protein expression in the prefrontal cortex (PFC) in 6 age groups of normal individuals. COMT alters extracellular dopamine levels in PFC and its ge ...
110.
MH002865 (2007) Reproductive Endocrine Related Mood Disorders-Differential Sensitivity
Peter J Schmidt, MD
Our major research findings are as follows: 1) The first demonstration of an association between polymorphic genetic variants and premenstrual dysphoric disorder (PMD). Four single nucleotide polymorphisms in the estrogen receptor alpha gene positively associate with the disorder, and evidence for ...
111.
MH002866 (2007) Treatment of childhood regresive autism with minocycline.
David M. Neville, MD
Autism is a neurodevelopmental disorder that results in abnormalities of social and language development and is associated with rigid and repetitive behaviors. Although there is strong evidence of heritability, the involved genes have not been identified. The prevalence of autism spectrum disorder ...
112.
MH002867 (2007) Neural mechanisms for genetic contributions to psychiatric disease and behavior
Andreas Meyer-Lindenberg, MD, PhD
Is the wiring of the human brain genetically influenced? In this work, we used diffusion tensor imaging (DTI) to study extremely rare individuals with Williams syndrome (WS). This highly uncommon genetic disorder is caused by a microdeletion of approximately 25 genes on chromosome 7, and provided an ...
113.
MH002868 (2007) Studies of Autism and Related Disorders
Susan Elizabeth Swedo, MD
Autism is currently defined as a single disorder characterized by impairments in communication and social interaction and the presence of restricted or repetitive behaviors. The current diagnostic definition is based on behavioral characteristics, but there is mounting evidence that autism may be ...
114.
MH002869 (2007) Characterization of Dentate Mossy Cell-restricted Genetic Manipulation Mice
Kazutoshi Nakazawa, MD, PhD
It is widely known that the hippocampus is critically involved in acquisition and retrieval of episodic memory and the dentate gyrus is the central information processor for sensory inputs to the hippocampus. The mossy cells in the dentate hilus are the only glutamatergic non-principal cells in the ...
115.
MH002870 (2007) National Health And Nutrition Examination Survey (NHANES)
Kathleen R Merikangas, PhD
Background: The NHANES is a program of studies designed to assess the health and nutritional status of adults and children in the US. The survey is unique in that it combines interview and physical examinations. It is a continuous program that collects a nationally representative sample of 5000 pe ...
116.
MH002871 (2007) Investigation of NMDA receptor antagonist as antidepressant in animals
Husseini K Manji, MD
Our recent double blind clinical trials demonstrated that ketamine (an NMDA antagonist) produced rapid onset, robust, and long-pasting antidepressive actions in the patients who are resistant to typical antidepressant treatment. We have hypothesized that targeting AMPA/NMDA receptor throughput ...
117.
MH002872 (2007) Roles of kainate receptors in behavioral plasticity related to mood disorders
Husseini K Manji, MD
Kainate receptors (KARs) regulate the release of glutamate and GABA and synaptic plasticity in different brain regions involved in mood regulation, including the anterior-cingulate cortex, hippocampus, and amygdala. The KAR family includes five subunits: GluR5-7 and KA-1-2 (also called glutama ...
118.
MH002873 (2007) Neurophysiological Risk for Adolescent Social Phobia
Daniel Pine, MD
Adolescent anxiety disorders are prevalent, markedly impairing, and predictive of high risk for adult anxiety, depression, and suicide. Identifying early childhood predictors of anxiety would allow us to target children most in need of intervention. Although behavioral inhibition is not a psych ...
119.
MH002874 (2007) The Neuroregulatory Effects of Gonadal Steroids in Humans
Peter J Schmidt, MD
We have been able to examine directly the effects of acute hypogonadism and individual gonadal steroid replacement in both men and women on the following measures: mood and behavior, cognitive test performance, neuroendocrine serotonergic system function (mCPP pharmacologic challenges and DASB brain ...
120.
MH002875 (2007) The Frontal Lobe in Symbolically Guided Decisions
Steven P Wise, PhD
The Section on Neurophysiology studies the frontal cortex and related parts of the brain. In the recent past, we have focused on the use of symbols to guide action, a process that we call symbolic mapping. Making decisions based on symbols is a fundamental feature of daily life, and diseases such as ...
121.
MH002876 (2007) The Frontal Lobe and Basal Ganglia in Behavioral Inhibition and Selection
Steven P Wise, PhD
The Section on Neurophysiology studies the frontal cortex and related parts of the brain. The present project was premised on the idea that making decisions about what to do and when to do it requires three distinct neural processes: comparison of the relative value of alternative actions (known as ...
122.
MH002878 (2007) The Frontal Lobes and Goal Selection Based on Strategies and Supramodal Inputs
Steven P Wise, PhD
The Section on Neurophysiology studies the frontal cortex and related parts of the brain. In this project, we have focused on the mechanisms of abstract response strategies and judgments about supramodal inputs, such as relative duration and distance, in the selection of future goals. Supramodal sig ...
123.
MH002881 (2007) Apoptotic molecules in synapse plasticity
Zheng Li, PhD
The release of apoptotic molecules from mitochondria is activated by the pro-apoptotic Bcl-2 proteins in programmed cell death. We first ask whether the pro-apoptotic Bcl-2 proteins activate mitochondria in long-term depression (LTD). We will alter the expression of pro-apoptotic Bcl-2 proteins in h ...
124.
MH002882 (2007) Neuregulin in the development of hippocampal neurons
Zheng Li, PhD
We are investigating the subcellular localization and effect of overexpressing neuregulin in hippocampal neurons. We observed that neuregulin exists in clusters in hippocampal neurons. We are examining whether these neuregulin clusters associate with specific subcellular compartments. We are also an ...
125.
MH002884 (2007) Functional MRI Core Facility
Peter A Bandettini, BS, PhD
Space Utilization:
The FMRIF currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3T-1, 3T-2, and the FMRIF 1.5T system in the NMR Center (about 1500 sq ft, 1100 sq ft and 800 sq ft respectively) and office space ...
126.
MH002886 (2007) Neural mechanisms of reward processing and emotion
Elisabeth Adams Murray, PhD
One popular model suggest that PFo, in particular, represents value in a common currency. A common value system would allow comparison of different goods (e.g., apples and oranges), and would constitute an important mechanism for making advantageous choices. We propose to test the idea that PFo and ...
127.
MH002887 (2007) Neural substrates of reward processing and emotion
Elisabeth Adams Murray, PhD
Several investigators have suggested that a single functional circuit underlies emotion and reward processing. The circuit is thought to include the amygdala and PFo; the amygdala and PFo are anatomically related and the behavioral profiles that follow damage to each region are similar. For example, ...
128.
MH002888 (2007) Scientific and Statistical Computing Core
Robert Cox, PhD
The mission of the Scientific and Statistical Computing Core is to help NIH researchers with analysis of their functional MRI data. Several levels of help are provided, ranging from short-term immediate aid to long-term development and planning.
Consultations:
The shortest term help consists of ...
129.
MH002889 (2007) NIMH MEG Core Facility
Richard Coppola, SB, DSc
At present we have about 40 user accounts representing numerous NIMH, NINDS and NIDCD protocols. There is continual interest from additional groups that are working on protocols and planning studies.
The MEG Core staff has been working interactively with these users in terms of study des ...
130.
MH002890 (2007) Integrating EEG/MEG and fMRI: 99-M-0172
Richard Coppola, SB, DSc
Development of MEG data recording and signal processing methods has been very successful. Studies of working memory tasks and auditory processing tasks have shown the ability to localize brain activation and to address issues of phasic versus tonic activity. We have also begun to investigate phenoty ...
131.
MH002891 (2007) Antibody Microarray Study of Samples From Depressed Patients
David M Jacobowitz, PhD
Antibody Microarray Study of CSF Samples From Depressed Patients
1.0 Introduction and Specific Aim:
Our specific aim has been to identify prospective biomarkers for disease and to develop candidate targets for drug discovery.
1.1. Rationale:
The medical rationale is based upon ...
132.
MH002892 (2007) Synaptic mechanisms of amygdala-dependent behaviors
Alexei Y Morozov, PhD
Amygdala regulates emotional behaviors by processing sensory information and by triggering defensive responses in the lower brain structures. Synaptic plasticity in the sensory inputs to amygdala is believed to be a mechanism for auditory fear conditioning which is a simple model of emotional learni ...
133.
MH002893 (2007) Learning and plasticity in the human brain
Christopher Ian Baker, PhD
Our research program is concerned with elucidating the neural changes associated with learning and experience, particularly in the context of vision. In the past year we have focused on identifying neural changes underlying learning of visual stimuli (such as complex novel objects) and on determinin ...
134.
MH002894 (2007) Magnetic Resonance Spectroscopy Core Facility
Jun Shen, PhD
In addition to provide technical support on developed MRS protocols, significant progress have been made in developing new spectroscopy protocols for studying patients.
By measuring the turnover of glutamate, glutamine and GABA from carbon-13-labeled glucose, carbon-13 MRS provides information o ...
135.
MH002895 (2007) Forebrain GABAergic cell-selective genetic manipulation in mice
Kazutoshi Nakazawa, MD, PhD
Local GABAergic interneurons sculpt the activities in cortical circuits controlling excitability and timing of principal neurons. They have been implicated in the generation and control of theta/gamma frequency oscillations and in the normal development of cortical circuitry, including the regulatio ...
136.
MH002896 (2007) The Neural Basis of Functional MRI Responses
David A Leopold, PhD
The Unit on Cognitive Neurophysiology and Imaging (UCNI) is working closely together with the neighboring Neurophysiology Imaging Facility (NIF) to elaborate the relationship between electrical neural brain signals signals, measurable with microelectrodes, and functional neuroimaging signals, measur ...
137.
MH002897 (2007) Molecular and Cellular Mechanisms of Experience-Dependent Cortical Processing
Kuan Hong Wang, PhD
We are investigating the coupling mechanisms between sensory stimuli evoked neuronal activity and plasticity-related gene expression in cortical circuits, using calcium-sensitive fluorescent dyes and genetically encoded fluorescent reporters for the activity-regulated gene Arc. Particularly, we are ...
138.
MH002898 (2007) Visual Adaptation and Neuronal Selectivity
David A Leopold, PhD
A striking feature of visual processing in the primate brain is the existence of neurons that are reactive to pictures of highly specific stimuli, such as faces or complex objects with which an animal or human is familiar. While the existence of these neurons is clearly related to learning and memo ...
139.
MH002899 (2007) Neurophysiology Imaging Facility Core: Functional and Structural MRI
David A Leopold, PhD
The advent of human fMRI has changed the focus of modern neuroscience, highlighting processes in the human brain. This macroscopic description of brain function is highly useful for addressing large-scale processes, and the extension of neuroscience to humans has been critical for learning about bra ...
140.
MH002901 (2007) Transgenic animal production for neuroscience research
James M Pickel, AB, PhD
Creation of disease models:
Human disease models for two neurological disorders were developed by the core facility over the last year. Because the critical genes involved in these diseases has been defined the mouse gene could be identified and modified to match the genetic change that leads to ...
141.
MH002902 (2007) NIMH Non-Human Primate Research Core
James T Winslow
Assessment of neural and behavioral alterations associated with chronic fluoxetine administration in adolescence.
Summary: A major public health concern has emerged regarding the treatment of children with psychotherapeutic drugs. This study seeks to inform this imortant concern. A primate differ ...
142.
MH002903 (2007) Procurement and Characterization of Postmortem Brain Tissue
Joel Kleinman, MD, PhD
This year we have collected 58 brains
To date we have collected: 1,017 brains
Diagnosis: Schizophrenia 147; Bipolar 40; Major Depressive Disorder 76; Normal Control 271; Affective Disorder 49; Substance Abuse 161; Fetal Brain 44; Others 171; and 58 to be characterized
The major focus of our ...
143.
MH002904 (2007) Biological Characterization of Genetic Mechanisms in Neuropsychiatric Disorders
Daniel R. Weinberger, MD
Genes are major contributors to many psychiatric diseases, but their mechanisms of action have long seemed elusive. To date, we have evidence of association with schizophrenia in our family datasets of at least the following genes: COMT, DTNBP1, MUTED, EAA1, MRDS1, GAD1, DISC1, FEZ1, CITRON, NDE1, ...
144.
MH002905 (2007) Neuroimaging Core Facility
Venkata S. Mattay, MD
In our organizational outline the core covers the following neuroimaging domains:
1. Structural MRI: acquisition, quality control, segmentation, automated and manual region-of-
interest (ROI)
definition and measurements, surface extraction
2. Functional MRI: acquisition, qualit ...
145.
MH002906 (2007) Transgenic Mouse Model for Mental Disorders including schizophrenia
Jingshan Chen
Genetic mouse models based on genetic susceptibility are still in their infancy. Studying the roles of susceptibility genes in cognitive processing, neuronal function, and signal transduction in the brain during development, as well as their interactions with environmental factors, will most likely ...
146.
MH002907 (2007) Blood Genomics Approach for Neuropsychiatric Disorders
Yoshitatsu Sei
Schizophrenia is a complex psychiatric disease with a strong genetic predisposition. Linkage and association studies in different ethnic populations implicate Neuregulin 1 (NRG1) as a candidate susceptibility gene for schizophrenia. NRG1 functions by interacting with ErbB tyrosine kinase receptors ...
147.
MH002908 (2007) Genetics and Bioinformatics Core Laboratory
Daniel R. Weinberger, MD
To date, we have tested numerous single nucleotide polymorphisms (SNPs) in well over 118 genes, including some of the less established but intriguing candidates such as PRODH, RGS4, CHRNA7, PIP5K2A, and PPP3CC. Among our accomplishments, we have fully sequenced the 10 exons and 2.5 kb of the 5 flank ...


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2 Basic types
In this chapter we will learn more about Elixir basic types: integers, floats, booleans, atoms, strings, lists and tuples. Some basic types are:
iex> 1 # integer
iex> 0x1F # integer
iex> 1.0 # float
iex> true # boolean
iex> :atom # atom / symbol
iex> "elixir" # string
iex> [1, 2, 3] # list
iex> {1, 2, 3} # tuple
2.1 Basic arithmetic
Open up iex
and type the following expressions:
iex> 1 + 2
3
iex> 5 * 5
25
iex> 10 / 2
5.0
Notice that 10 / 2
returned a float 5.0
instead of an integer 5
. This is expected. In Elixir, the operator /
always returns a float. If you want to do integer division or get the division remainder, you can invoke the div
and rem
functions:
iex> div(10, 2)
5
iex> div 10, 2
5
iex> rem 10, 3
1
Notice that parentheses are not required in order to invoke a function.
Elixir also supports shortcut notations for entering binary, octal and hexadecimal numbers:
iex> 0b1010
10
iex> 0o777
511
iex> 0x1F
31
Float numbers require a dot followed by at least one digit and also support e
for the exponent number:
iex> 1.0
1.0
iex> 1.0e-10
1.0e-10
Floats in Elixir are 64 bit double precision.
You can invoke the round
function to get the closest integer to a given float, or the trunc
function to get the integer part of a float.
iex> round 3.58
4
iex> trunc 3.58
3
2.2 Booleans
Elixir supports true
and false
as booleans:
iex> true
true
iex> true == false
false
Elixir provides a bunch of predicate functions to check for a value type. For example, the is_boolean/1
function can be used to check if a value is a boolean or not:
Note: Functions in Elixir are identified by name and by number of arguments (i.e. arity). Therefore,
is_boolean/1
identifies a function namedis_boolean
that takes 1 argument.is_boolean/2
identifies a different (nonexistent) function with the same name but different arity.
iex> is_boolean(true)
true
iex> is_boolean(1)
false
You can also use is_integer/1
, is_float/1
or is_number/1
to check, respectively, if an argument is an integer, a float or either.
Note: At any moment you can type
h
in the shell to print information on how to use the shell. Theh
helper can also be used to access documentation for any function. For example, typingh is_integer/1
is going to print the documentation for theis_integer/1
function. It also works with operators and other constructs (tryh ==/2
).
2.3 Atoms
Atoms are constants where their name is their own value. Some other languages call these symbols:
iex> :hello
:hello
iex> :hello == :world
false
The booleans true
and false
are, in fact, atoms:
iex> true == :true
true
iex> is_atom(false)
true
iex> is_boolean(:false)
true
2.4 Strings
Strings in Elixir are inserted between double quotes, and they are encoded in UTF-8:
iex> "hellö"
"hellö"
Note: if you are running on Windows, there is a chance your terminal does not use UTF-8 by default. You can change the encoding of your current session by running
chcp 65001
.
Elixir also supports string interpolation:
iex> "hellö #{:world}"
"hellö world"
Strings can have line breaks in them or introduce them using escape sequences:
iex> "hello
...> world"
"hello\nworld"
iex> "hello\nworld"
"hello\nworld"
You can print a string using the IO.puts/1
function from the IO
module:
iex> IO.puts "hello\nworld"
hello
world
:ok
Notice the IO.puts/1
function returns the atom :ok
as result after printing.
Strings in Elixir are represented internally by binaries which are sequences of bytes:
iex> is_binary("hellö")
true
We can also get the number of bytes in a string:
iex> byte_size("hellö")
6
Notice the number of bytes in that string is 6, even though it has 5 characters. That's because the character "ö" takes 2 bytes to be represented in UTF-8. We can get the actual length of the string, based on the number of characters, by using the String.length/1
function:
iex> String.length("hellö")
5
The String module contains a bunch of functions that operate on strings as defined in the Unicode standard:
iex> String.upcase("hellö")
"HELLÖ"
2.5 Anonymous functions
Functions are delimited by the keywords fn
and end
:
iex> add = fn a, b -> a + b end
#Function<12.71889879/2 in :erl_eval.expr/5>
iex> is_function(add)
true
iex> is_function(add, 2)
true
iex> is_function(add, 1)
false
iex> add.(1, 2)
3
Functions are "first class citizens" in Elixir meaning they can be passed as arguments to other functions just as integers and strings can. In the example, we have passed the function in the variable add
to the is_function/1
function which correctly returned true
. We can also check the arity of the function by calling is_function/2
.
Note a dot (.
) between the variable and parenthesis is required to invoke an anonymous function.
Anonymous functions are closures, and as such they can access variables that are in scope when the function is defined:
iex> add_two = fn a -> add.(a, 2) end
#Function<6.71889879/1 in :erl_eval.expr/5>
iex> add_two.(2)
4
Keep in mind that a variable assigned inside a function does not affect its surrounding environment:
iex> x = 42
42
iex> (fn -> x = 0 end).()
0
iex> x
42
2.6 (Linked) Lists
Elixir uses square brackets to specify a list of values. Values can be of any type:
iex> [1, 2, true, 3]
[1, 2, true, 3]
iex> length [1, 2, 3]
3
Two lists can be concatenated and subtracted using the ++/2
and --/2
operators:
iex> [1, 2, 3] ++ [4, 5, 6]
[1, 2, 3, 4, 5, 6]
iex> [1, true, 2, false, 3, true] -- [true, false]
[1, 2, 3, true]
Throughout the tutorial, we will talk a lot about the head and tail of a list. The head is the first element of a list and the tail is the remainder of a list. They can be retrieved with the functions hd/1
and tl/1
. Let's assign a list to a variable and retrieve its head and tail:
iex> list = [1,2,3]
iex> hd(list)
1
iex> tl(list)
[2, 3]
Getting the head or the tail of an empty list is an error:
iex> hd []
** (ArgumentError) argument error
Sometimes you will create a list and it will return a value in single-quotes. For example:
iex> [11, 12, 13]
'\v\f\r'
iex> [104, 101, 108, 108, 111]
'hello'
When Elixir sees a list of printable ASCII numbers, Elixir will print that as a char list (literally a list of characters). Char lists are quite common when interfacing with existing Erlang code.
Keep in mind single-quoted and double-quoted representations are not equivalent in Elixir as they are represented by different types:
iex> 'hello' == "hello"
false
Single-quotes are char lists, double-quotes are strings. We will talk more about them in the "Binaries, strings and char lists" chapter.
2.7 Tuples
Elixir uses curly brackets to define tuples. Like lists, tuples can hold any value:
iex> {:ok, "hello"}
{:ok, "hello"}
iex> tuple_size {:ok, "hello"}
2
Tuples store elements contiguously in memory. This means accessing a tuple element per index or getting the tuple size is a fast operation (indexes start from zero):
iex> tuple = {:ok, "hello"}
{:ok, "hello"}
iex> elem(tuple, 1)
"hello"
iex> tuple_size(tuple)
2
It is also possible to set an element at a particular index in a tuple with put_elem/3
:
iex> tuple = {:ok, "hello"}
{:ok, "hello"}
iex> put_elem(tuple, 1, "world")
{:ok, "world"}
iex> tuple
{:ok, "hello"}
Notice that put_elem/3
returned a new tuple. The original tuple stored in the tuple
variable was not modified because Elixir data types are immutable. By being immutable, Elixir code is easier to reason about as you never need to worry if a particular code is mutating your data structure in place.
By being immutable, Elixir also helps eliminate common cases where concurrent code has race conditions because two different entities are trying to change a data structure at the same time.
2.8 Lists or tuples?
What is the difference between lists and tuples?
Lists are stored in memory as linked lists, meaning that each element in a list holds its value and points to the following element until the end of the list is reached. We call each pair of value and pointer a cons cell:
iex> list = [1|[2|[3|[]]]]
[1, 2, 3]
This means accessing the length of a list is a linear operation: we need to traverse the whole list in order to figure out its size. Updating a list is fast as long as we are prepending elements:
iex> [0] ++ list
[0, 1, 2, 3]
iex> list ++ [4]
[1, 2, 3, 4]
The first operation is fast because we are simply adding a new cons that points to the remaining of list
. The second one is slow because we need to rebuild the whole list and add a new element to the end.
Tuples, on the other hand, are stored contiguously in memory. This means getting the tuple size or accessing an element by index is fast. However, updating or adding elements to tuples is expensive because it requires copying the whole tuple in memory.
Those performance characteristics dictate the usage of those data structures. One very common use case for tuples is to use them to return extra information from a function. For example, File.read/1
is a function that can be used to read file contents and it returns tuples:
iex> File.read("path/to/existing/file")
{:ok, "... contents ..."}
iex> File.read("path/to/unknown/file")
{:error, :enoent}
If the path given to File.read/1
exists, it returns a tuple with the atom :ok
as the first element and the file contents as the second. Otherwise, it returns a tuple with :error
and the error description.
Most of the time, Elixir is going to guide you to do the right thing. For example, there is a elem/2
function to access a tuple item but there is no built-in equivalent for lists:
iex> tuple = {:ok, "hello"}
{:ok, "hello"}
iex> elem(tuple, 1)
"hello"
When "counting" the number of elements in a data structure, Elixir also abides by a simple rule: the function should be named size
if the operation is in constant time (i.e. the value is pre-calculated) or length
if the operation requires explicit counting.
For example, we have used 4 counting functions so far: byte_size/1
(for the number of bytes in a string), tuple_size/1
(for the tuple size), length/1
(for the list length) and String.length/1
(for the number of characters in a string). That said, we use byte_size
to get the number of bytes in a string, which is cheap, but retrieving the number of unicode characters uses String.length
, since the whole string needs to be iterated.
Elixir also provides Port
, Reference
and PID
as data types (usually used in process communication), and we will take a quick look at them when talking about processes. For now, let's take a look at some of the basic operators that go with our basic types.


Project Description
3D Thematic Mapping is a program for visualizing geospatial data on a globe. Cylindrical bars normal to the center of each country are scaled and colored based on the value of some variable such as population.
Controls:
- h - move left/west
- j - move down/south
- k - move up/north
- l - move right/east
- i - zoom in
- o - zoom out
Details
Data is from the World Development Indicators provided by the World Bank. As is the program displays population data from 2016.


Symbol Index for "Value Category"
Symbol Index for diagram
"Value Category"
Associative Category (Class)
Cat/Scope (Generalization Node)
Category (Class)
Category Valued Qualifier (Class)
Descriptive Category (Class)
value (Association)
Value Category (Class)


"A work of art is above all an adventure of the mind." - Eugene Lonesco
I live with my mom, dad, and my two brothers; Eric(15) and Ethan(15). We live in a simple neighborhood known as Elk Run Heights. Eric and Ethan are bother Freshmen at East High School. I like to do Football and gaming during free time and currently am an intern over at the Waterloo Tech Facility (WTF). I have two pets, one is a Cavalier King Charles Spaniel named Daisy and the other is a Calico named Lucy.
| Name | How I Know Them | Phone | |
| Richard Hurban | Mentor for FTC and FRC robotics teams |<PHONE_NUMBER> |<EMAIL_ADDRESS>|
| Kyle Kuhlers | Intro to Web Development Teacher |<PHONE_NUMBER> |<EMAIL_ADDRESS>|


05.Write script that asks for a digit and depending on the input shows the name of that digit (in English) using a switch statement.
Input number:
Print


Preparation time
30 mins to 1 hour
Cooking time
less than 10 mins
Serves
Makes 10 skewers
To make the mozzarella skewers, heat the olive oil in a small pan and gently sweat the garlic, thyme and lemon zest for 2-3 minutes to soften and infuse. Remove from the heat and stir the lemon juice through. Allow to cool.  Season and toss the cayenne and parsley through. Leave to marinade for as long as possible.
 (Reserve one melon half shell.) Wrap a piece of parma ham around each melon ball.
Alternatively, arrange each of two mozzarella balls, melon balls and cherry tomatoes on each of 10 wooden skewers. Turn the reserved melon half shell, cut side down onto a plate or into a bowl and stick the prepared skewers in to display. Serve.


Headless rendering¶
This tutorial explains how to render and save images from a terminal without any display device.
Note
This feature is experimental; it was only tested with Ubuntu 16.04 environment.
Install OSMesa¶
To generate a headless context, it is necessary to install OSMesa.
$ sudo apt-get install libosmesa6-dev
Otherwise, a recent version of OSMesa can be built from source.
# download OSMesa 2018 release
$ cd
$ wget ftp://ftp.freedesktop.org/pub/mesa/mesa-18.0.0.tar.gz
$ tar xf mesa-18.0.0.tar.gz
$ cd mesa-18.0.0/
# configure compile option and build
$ ./configure --enable-osmesa --disable-driglx-direct --disable-gbm --enable-dri --with-gallium-drivers=swrast
$ make
# add OSMesa to local path.
$ export PATH=$PATH:~/mesa-18.0.0
Install virtualenv¶
The next step is to make a virtual environment for Python.
$ sudo apt-get install virtualenv python-pip
$ virtualenv -p /usr/bin/python3 py3env
$ source py3env/bin/activate
(py3env) $ pip install numpy matplotlib
This script installs and activates py3env
. The necessary modules, numpy
and matplotlib
, are installed in py3env
.
Error
Anaconda users are recommended to use this configuration as conda install matplotlib
installs additional modules that are not based on OSMesa.
This will result in segmentation fault error at runtime.
Build Open3D with OSMesa¶
Let’s move to build a folder.
(py3env) $ cd ~/Open3D/
(py3env) $ mkdir build && cd build
In the next step, there are two cmake flags that need to be specified.
-DENABLE_HEADLESS_RENDERING=ON
: this flag informs glew and glfw should use OSMesa.-DBUILD_GLEW=ON -DBUILD_GLFW=ON
: note that headless rendering only works with the glew 2.1 and glfw 3.3-dev version. In most cases, these versions are not installed in vanilla Ubuntu systems. Use these CMake options to force to build glew 2.1 and glfw 3.3-dev from source.
As a result, the cmake command is the following
(py3env) $ cmake -DENABLE_HEADLESS_RENDERING=ON \
-DBUILD_GLEW=ON \
-DBUILD_GLFW=ON \
-DPYTHON_EXECUTABLE:FILEPATH=/usr/bin/python3 \
..
Note that -DPYTHON_EXECUTABLE:FILEPATH=/usr/bin/python3
is the same path that was used for Install virtualenv.
If cmake successfully generates makefiles, build Open3D.
(py3env) $ make # or make -j in multi-core machine
Test headless rendering¶
As a final step, test a Python script that saves depth and surface normal sequences.
(py3env) $ cd ~/Open3D/build/lib/Tutorial/Advanced/
(py3env) $ python headless_rendering.py
This should print the following:
Capture image 00000
Capture image 00001
Capture image 00002
Capture image 00003
Capture image 00004
Capture image 00005
:
Capture image 00030
Rendered images are at ~/Open3D/build/lib/TestData/depth and the image folder.
Note
headless_rendering.py
saves png files.Error
cmake
with -DBUILD_GLEW=ON
and -DBUILD_GLFW=ON
flags.


Meteo Demo
Meteo Demo
Shows the temperature historic for stations monitoring the weather arround the world
Select station:
Show temperatures
Period filter
Dates filter
Splout qNode Address:
Change


- Sublime
- Atom
- Brackets
- Adobe Dreamviewer
- Bootstrap
Software
- Rhino ( 2D & 3d Design) | 90 Days trial
- Rhino Wip ( Parametric Design) | 200 mb | Trail Version 30 Days
- Cut Studio (Vinyl Cutting)
Tools
- Epilog Laser Cutter
- Roland Vinyl Cutter
Files
- Basic Bot Body from for Gear Motor
- Roland Vinyl Cutter


Services within two industies: Information Technology Webpage content and site design with limited branding design AWS Cloud Platform Photography Porfolio


Format: BackdropLeftFile FilePath,
Example: BackdropLeftFile "UI\Widgets\ButtonLeft.blp",
Purpose: Set the Texture for the left part of the Border
Used in: BACKDROP


The input CSV file includes one header line (manditory) and lines of
records following it. The header line defines the format for each
record line. And each record line contains the information of one
media record.
The fields are separated by ','(comma) and each is surrounded by '"'
(double quotation marks). Two fields must be provided:
"idigbio:OriginalFileName" (the path of the media file in the local
file system) and "idigbio:MediaGUID" (the GUID of the media file).
Users can define any other fields.
Example 1, Example 2, Example 3


--- layout: post status: publish published: true title: Custom PropPage in R2 Sample author: display_name: Tomas Restrepo login: tomasr email<EMAIL_ADDRESS>url: http://winterdom.com/ author_login: tomasr author_email<EMAIL_ADDRESS>author_url: http://winterdom.com/ wordpress_id: 170 wordpress_url: http://winterdom.com/2007/10/customproppageinr2sample date: '2007-10-23 07:14:30 +0000' date_gmt: '2007-10-23 07:14:30 +0000' categories: - BizTalk tags: [] comments: - id: 1542 author: Marge author_email<EMAIL_ADDRESS>author_url: '' date: '2010-07-23 20:51:37 +0000' date_gmt: '2010-07-23 20:51:37 +0000' content: "Hi, thank you for your posting.\r\nWill this adapter work for BizTalk 2009?" - id: 1543 author: Tomas Restrepo author_email<EMAIL_ADDRESS>author_url: http://winterdom.com/ date: '2010-07-24 14:07:53 +0000' date_gmt: '2010-07-24 14:07:53 +0000' content: It should work on 2009. - id: 1669 author: Arnold author_email<EMAIL_ADDRESS>author_url: '' date: '2011-02-11 11:48:36 +0000' date_gmt: '2011-02-11 11:48:36 +0000' content: "I've got an outofmemoryexception in Biztalk 2010 when I load the configuration of the /dev/null adapter when I create a send port with it. \r\n\r\nCan you help me with this?\r\n\r\nHereby the details from a trace: \r\n\r\n[3612] \ \r\n[3612] Microsoft.BizTalk.Adapter.Framework.Forms.AdapterProxy: Void .ctor(System.String) \r\n[3612] adapterGuid={a5caaa62-07e6-46c2-b9e1-68fc2fe30dcd} \r\n[3612] Microsoft.BizTalk.Adapter.Framework.Forms.AdapterProxy: Void ReadAdapterInfoFromRegistry() \r\n[3612] Microsoft.BizTalk.Adapter.Framework.Forms.AdapterProxy: Void Instantiate() \r\n[3612] adapterName=/dev/null adapter \r\n[3612] \ assemblyFile=C:\\install\\NullAdapter\\Winterdom.BizTalk.Adapters.NullAdapter.dll \r\n[3612] typeName=Winterdom.BizTalk.Adapters.NullAdapterMgmt \r\n[3612] Microsoft.BizTalk.Adapter.Framework.Forms.FrameworkPropertyGrid: Void set_XsdSchema(System.String) \r\n\r\n.....\r\n\r\n[3612] System.NullReferenceException: Object reference not set to an instance of an object. \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Xsd.XsdSchema.get_IsRootSimple() \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Xsd.XsdSchema.get_RootName() \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Compiler.get_RootInstance() \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Specification.LoadSchema(String schema) \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Specification.set_XsdSchema(String value) \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Forms.FrameworkPropertyGrid.set_XsdSchema(String value) \r\n[3612] System.OutOfMemoryException: Exception of type 'System.OutOfMemoryException' was thrown. \r\n[3612] at System.Text.StringBuilder.ExpandByABlock(Int32 minBlockCharCount) \r\n[3612] at System.Text.StringBuilder.Append(Char* value, Int32 valueCount) \r\n[3612] at System.Text.StringBuilder.AppendHelper(String value) \r\n[3612] \ at System.Text.StringBuilder.Append(String value) \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Forms.FrameworkPropertyGrid.ShowException(String stage, Exception exception) \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Forms.FrameworkPropertyGrid.set_XsdSchema(String value) \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Forms.SpecificationGrid.set_XsdSchema(String value) \r\n[3612] at Microsoft.BizTalk.Adapter.Framework.Forms.SpecificationGrid.Microsoft.BizTalk.Adapter.Framework.Forms.IAFPropertyGrid.SetAdapterMgmtInfo(Object site, String mgmtGuid, String xmlInst, ConfigType configType)" ---
As promised, here's a sample managed adapter implementing a custom adapter configuration dialog for BizTalk Server 2006 R2. It isn't a fancy sample, just a new version of my /dev/null adapter with a simple, custom dialog. It should be enough, however, to illustrate the basic details needed to get you up and running quickly.
Here's a snapshot of the configuration dialog when invoked from the BizTalk Administration Console:
Some things I discovered that complement my previous article on the topic:
COM Registration: The class implementing IPropertyPageFrame needs to be registered with COM. However, you won't be able to use the "Register for COM interop" option in the Visual Studio project settings for this, because you'll get an error saying that the Microsoft.BizTalk.ExplorerOM.dll assembly isn't registered. To work around this, I created a custom build step that calls regasm.exe with the /registered option.
Property Bags: Remember I said you needed to implement two versions of IPersistPropertyBag? Turns out both are indeed needed. Even the BizTalk Administration Console will call both implementations at different times.
Also, it can become cumbersome to implement your adapter configuration load/save code for both IPropertyBag implementations, so I simply wrote a small adapter class that wraps the Microsoft.BizTalk.ExplorerOM.IPropertyBag instance so that it looks like a Microsoft.BizTalk.Admin.IPropertyBag one. This way I could write code just once to serialize/deserialize the adapter settings. You can find the wrapper class in PropBagAdapter.cs,
Registry: As usual, the adapter ships with a .REG file containing the adapter registry entries. Make sure to modify the file paths there so that they point to your project's location on disk. One thing worth noting here is how now the TransmitLocation_PageProv value contains the CLSID I explicitly gave to my TransmitLocPageProvider class (which implements IPropertyPageFrame).
Download: NullAdapterR2.zip.
I think you'll find the code is pretty straightforward and should give you an idea of how to get this up and running in your own adapters, if you're interested.


Attendance Management & Payroll Management System
| Employee Name |
Employee Designation |
Employee Department |
Employee Phone No |
Employee Salary |
Date-Time Created |
{% for e in employees %}
| {{e.Full_Name}} |
{{e.Designation}} |
{{e.Department}} |
{{e.Phone_No}} |
{{e.Salary}} |
{{e.Date_created}} |
{% endfor %}
| Employee Name |
Check-In Time |
Check-Out Time |
Full Hours Utilized |
Marked Attendance |
Date-Time Created |
{% for a in attendances %}
| {{a.Employee_Name}} |
{{a.Time_In}} |
{{a.Time_Out}} |
{{a.FullHours_Utilized}} |
{{a.Mark_Attendance}} |
{{a.Date_created}} |
{% endfor %}
{% endblock %}


Cornell Hacking Club
Friday, Sept. 14 4:00 pm - Sunday Sept. 16 4:00 pm
Volunteer in Slack for recruitment challenges
Kick-off CTF for recruitment?
Ideas?


We took the hike to Summit Lake which is the closets lake to Three Finger Jack on the south side. The trails follows the Pacific Crest Trail for about 6 kilometers, and then splits off for last half a kilometer on an unmaintained trail which was a little hard for us to find. We ended up passing the turn and trail blazed to a cliff that over looks Summit Lake, but with some perseverance and back tracking we found a route to Summit Lake. Overall, the hike was a nice short trek with some spectacular views.
This is a image of Summit Lake looking southwest. The cliff we found that overlooks summit lake is to the right but out the image.
The start of the trail is an access point to the Pacific Crest trail on Highway 20 in Central Oregon. We were thinking of bringing our drone but learned that the wilderness area is a no drone fly zone. The parking lot was full of horse trailers so we expected to encounter horses on the trail, and we did come across several on the trail.
About a kilometer and a half into the hike we came to meadow that was full of lavender. There was a little pond at the north end of the meadow that Finn took a swim in, and at end of the meadow the trail splits. The left trail (Trail 3491) which would take you the Eights Lakes Basin or the Marion Flats, and the right trail is the Pacific Crest Trail which will take you to Summit lake or Canada.
There is only one real switchback on this hike which brings you up to the Casaide Divide. The view from here is pretty sweet- to the south you can see the Three Sisters, Mount Washington and maybe Mount Bachelor. I was also testing out my new black river shoes for creek crossings, and by this point they were a solid brown.
Along the ridge we hit the unburnt tree line (about 5 kilometers into the hike). The tree shade still had some snow pack which Finn was estatic to see. He learned to slide around on the snow to cool off, at least until he saw a another little creature to chase up a tree.
About 5.8 kilometers into the hike is a section that cuts across a steep side of the bottom of Three Finger Jack. This steep slope gives the most dramatic view of the trek, showing Mount Washington, the Sisters, Mount Bachelor and Black butte on the far left. However, just ahead is where the trail splits so keep your eyes peeled for trails on the right. If your bearing after this point turns West you have gone to far and missed the turn to Summit Lake.
After 6.5 kilometers, along with a few detours, we made it to Summit Lake. The lake was cold as expected, and sadly no fish. But due to the obscurity of the trail no other hikers were there and we camped in solitude.


--- layout: post title: Classics in Lego - a set on Flickr date: '2008-06-09T08:09:45+01:00' tags: [] tumblr_url: http://backlog.robbevan.com/post/37694757/classics-in-lego-a-set-on-flickr --- Classics in Lego - a set on Flickr


--- layout: skeleton --- Websites generated using Isomer Visit Site Hotels Licensing Board Visit Site Strategy Group


Please Enter your PRN and your grades for following courses. Keep NIL grade for courses that you haven't taken. Click on Proceed button.


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Tomcats * * (out of * * * * )
Directed by Gregory Poirier. Cast: Jerry O'Connell, Shannon Elizabeth, Jake Busey, Horatio Sanz, Jaime Pressly, Bill Maher, David Ogden Stiers, Bernie Casey, Garry Marshall. 2001 - 95 minutes Rated R (for profanity, sexuality, brief nudity, and cringe-inducing humor). Reviewed by Dustin Putman, March 31, 2001.
At this point in today's mainstream cinema, gross-out humor has become as prevalent as the appearance of Friday during each week. Last week's bid for yuks (as well as yucks) was "Say It Isn't So," and this week, it's "Tomcats," a raunchy-as-all-hell comedy written and directed by first-time filmmaker Gregory Poirier. Some of the material is very funny, to be sure, but much of it doesn't work because, like "Say It Isn't So," the editing isn't sharp enough to do the jokes complete justice. It doesn't help that a complete 20-minute portion of the movie forgets the premise and is solely devoted to the setup and payoff of a joke so gross it makes "Scary Movie" look relatively tame in comparison. Another 10-minute section sets up a dominatrix sequence involving an elderly woman that also has nothing to do with the story. There is a fine line between a movie that just so happens to be crass, and one whose only purpose is to turn stomachs.
The "plot" goes something like this: a group of male friends make a pact to make annual monetary contributions to a pot that will go to the one who remains single the longest, without getting married. By the time they hit 27, the pot has hit a cool half-million dollars, and only two of them have yet to tie the knot--Michael (Jerry O'Connell) and Kyle (Jake Busey). When Michael goes in debt after a bit of failed gambling in Vegas, he tracks down Natalie (Shannon Elizabeth), the one woman Kyle has slept with in his life whom he had actual feelings for. Having lost her virginity to Kyle seven years before, only to be nastily spurned by him and left with only a roll of quarters to call a taxi, Natalie decides to help Michael out and give Kyle a taste of his own medicine. Their plan entails her managing to steal his heart (no easy feat for such a cold-hearted womanizer) and marrying him, only to quickly get it annulled and share half of the money Michael will receive. In the process, Michael begins to fall in love with Natalie himself.
Sharing certain similarities with 2000's despicable "Whipped," "Tomcats" is a step above that picture, but shares the same downfall: none of the characters are likable people. Michael may be the protagonist, and therefore the nicest guy to be found, but his foregoing conclusion that all women are merely sex objects is awfully shallow and distasteful, particularly for a young man in his late-twenties. Michael is played by Jerry O'Connell (1999's "Body Shots"), a bright-faced veteran actor best known for playing the chubby, scaredy-cat Vern in 1986's "Stand by Me." O'Connell runs with the part, and goes all out in embarrassing himself in certain scenes, but he can't overcome the fact that Michael isn't a particularly interesting or amiable individual.
If there is anyone to care about (and I use such a term loosely), it is Natalie, played with an undeniable sweetness by Shannon Elizabeth (2000's "Scary Movie"). Natalie is a police officer who also happens to be an enormously beautiful woman. She is smart, strong-willed, and doesn't put up with being disrespected by anyone, so it comes off as somewhat of a contradiction that she would waste her time helping Michael out with something so childish. If Natalie is harmed by the confines of the dumb, if ambitiously disgusting, screenplay, it is solely thanks to Elizabeth that she remains an intelligent girl.
If the idea of watching a big, hospital-set chase scene for an enlarged, cancerous testicle that concludes in a cafeteria sounds potentially funny, then "Tomcats" may be worth a look. It most certainly can't be criticized for a lack of energy, and is entertaining to a point, but one has to wonder how low this crude genre can possibly go before it stops being innocently fun and just becomes an example of pointlessly offensive bad taste. "Tomcats," more so than most of the other recent films of its ilk, treads dangerously close to becoming the latter.
- Copyright 2001 by Dustin Putman http://us.imdb.com/ReviewsBy?Dustin+Putman http://www.atnzone.com
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