List all Reports for an Institute or Center for a particular year
All Annual Reports for NIMH for reporting year 2014
104 Annual Reports
Investigator-Initiated Project
1.
MH000332 (2014) Genetic Mouse Models for the Study of Serotonin, Dopamine and Glutamate Function and Behavior
Dennis L Murphy, MD
As recently reviewed by us, SERT-deficient +/- and -/- mice have gene-proportionate increases in extracellular fluid serotonin concentrations, i.e., 5- or 7-fold excesses respectively over wildtype +/+ mice. At the same time, SERT -/- mice have a marked deficit of intracellular, releasable serotonin ...
2.
MH000336 (2014) The Genetics of Obsessive Compulsive Disorder and Related OCD Spectrum Disorders
Dennis L Murphy, MD
OCD is a severe, heritable condition with a lifetime prevalence of about two percent in world populations. First-degree family members and OCD probands are at a ten-fold higher risk of developing OCD and related disorders. The mode of inheritance is incompletely understood but is likely complex, inv ...
3.
MH000478 (2014) Neural Mechanisms of Learning and Memory in Vision
Mortimer Mishkin, PhD
The essential circuit for both item and associative stimulus recognition in any given sensory modality consists of the relevant cortical sensory processing stream(s), the medial temporal periallocortex (i.e. posterior parahippocampal, perirhinal, and entorhinal cortices), the ventromedial prefrontal ...
4.
MH000889 (2014) Dysregulation of Protein Synthesis in Fragile X Syndrome
Carolyn E Beebe, PhD
The protocol involved in this project is 06-M-0214, NCT00362843.
Based on pathophysiological studies in animal models of FXS a number of compounds, including mGluR5 antagonists and GABA agonists, are being tested in human subjects. Preliminary preclinical and clinical studies indicated that trea ...
5.
MH001090 (2014) Studies Of Central Nervous System Functional Anatomy
Miles Herkenham, PhD
Part of our neuroimmune work is focused on the study in mice of neurobiological and immune system factors that contribute to depressive-like states induced by psychosocial stress, and we study the amelioration or prevention of these states by environmental enrichment coupled with voluntary wheel run ...
6.
MH001101 (2014) Neural Mechanisms of Learning and Memory in Audition
Mortimer Mishkin, PhD
The auditory cortex underlies are effortless ability to discriminate and remember complex sounds, including speech. The auditory cortex integrates spectral and temporal acoustic features to support the perception of complex sounds, including conspecific vocalizations. We investigated coding of vocal ...
7.
MH002032 (2014) Neural Coding Of Visual Stimuli
Barry J Richmond, MD
Categorization is considered a high level visual-perceptual function. It allows individuals to make reasonable guesses based on experience about the function and desirability of a stimulus or object. Monkeys, like humans, can classify whether images blending cats and dogs, so-called morphing from ca ...
8.
MH002035 (2014) Functional Anatomy Of Perceptual and Attentional Systems in the Primate Brain
Leslie G Ungerleider, PhD
A typical scene contains many different objects that compete for neural representation due to the limited processing capacity of the visual system. At the neural level, competition among multiple stimuli is evidenced by the mutual suppression of their visually evoked responses. The competition amo ...
9.
MH002039 (2014) Pharmacology Of Stimulus Memory And Habit Formation
Mortimer Mishkin, PhD
The memory impairment associated with Alzheimers disease has been associated with a loss in acetylcholine function and pathophysiology of the entorhinal/perirhinal, or rhinal cortex. Infusions of a selective cholinergic immunotoxin, lead to cholinergic deafferentation of the rhinal cortex and yielde ...
10.
MH002344 (2014) Neuropsychiatric Disorders--protein Structure/activity Studies
Susan G Amara, PhD
The unambiguous identification of proteins/peptides is crucial for the definition of the proteome. Using ProteinChip Array technology (SELDI) we have developed experimental protocols and probed test conditions required for protein identification on ProteinChip Arrays. We are able to directly digest ...
11.
MH002386 (2014) Chemical Coding Of Neurotransmission
Lee E Eiden, PhD
The neuropeptide slow transmitter PACAP (pituitary adenylate cyclase activating polypeptide) is released at synapses that transduce stress responses to the brain, and mediate homeostatic adjustments to stress by the organism. Allostatic responses to systemic and psychogenic stressors at multiple poi ...
12.
MH002399 (2014) Postmortem Brain Tissue Examination in Neuropsychiatric Disorders
Barbara K Lipska, PhD
Over the past year, we focused on several candidate genes for schizophrenia and affective disorders, and studied expression of multiple transcripts of these genes and their associations with schizophrenia risk-associated genotypes, such as DARPP-32, CHRNA7, and DRD1 and DRD2. For a DARPP-32 gene, we ...
13.
MH002468 (2014) Mechanisms Of Action Of Psychoactive Drugs
De Maw Chuang, PhD
We have used various experimental model systems to test the hypothesis that glycogen synthase kinase-3 (GSK-3) and histone deacetylases (HDACs) are initial targets of lithium and valproic acid (VPA), respectively, that trigger diverse neurobiological events including neuroprotective and neurotrophic ...
14.
MH002497 (2014) Functional Organization Of The Cerebral Cortex and Basal Ganglia
Charles R Gerfen, PhD
Advances in molecular genetic techniques are revealing new details of the neuronatomical organization of brain circuitry and the functional role of these circuits in behavior. Engineered viral vector constructs have been developed to label axonal projections of targeted neurons with unprecedent ...
15.
MH002498 (2014) Roles of Oxytocin and Vasopressin in Brain
Walter Scott Young, MD, PhD
--This fiscal year, we continued our studies of our gene knockouts (KO) of the mouse oxytocin (Oxt) and vasopressin (Avp) 1b receptors (Oxtr and Avpr1b, respectively) to investigate their specific roles in mediating behavior. Avp and Oxt are neurohormones that are best known for their peripheral act ...
16.
MH002537 (2014) Psychobiology And Treatment Of Perimenopausal Mood Disorders
Peter J Schmidt, MD
The protocols involved in this project are as follows: 02-M-0120, 03-M-0175, 88-M-0131, 92-M-0174. This report includes work arising from the following protocols: NCT00030147, NCT00060736, NCT00001231, and NCT00001322.
In addition to the established increased risk of first onset depression during t ...
17.
MH002581 (2014) Childhood Onset Schizophrenia
Judith L Rapoport, MD
In comparison with adult onset schizophrenia patients, childhood onset patients have a greater number of pre-psychotic developmental disorders. One fifth of our COS cases have earlier forms of autism spectrum disorder, and one third have motor, speech, language, attention or impulse related developm ...
18.
MH002588 (2014) The Neural Foundations for Memory and Social Cognition In The Human Brain
Alex Martin, PhD
This past year we have continued to focus on a major part of long-term memory, termed semantic memory, that is composed of general information, such as facts, ideas, and the meaning of objects and words. We are particularly interested in characterizing the neural substrate mediating object and word ...
19.
MH002592 (2014) Viral And Cellular Factors Governing Efficient Gene Delivery
Maribeth V Eiden, PhD
The Section on Directed Gene Delivery creates viral vectors to efficiently deliver genes to appropriate targets in cellula, at physiological expression stoichiometries, with the end goal of transferring therapeutic genes to cells of the central nervous system for expression at physiological levels t ...
20.
MH002619 (2014) Neural Mechanisms Of Motivation And Reward
Barry J Richmond, MD
Many psychiatric disorders have symptoms related to abnormal motivation. One clear example is depression, where patients describe feeling as though nothing is worthwhile, or worth working for. Learning how normal brain circuits give rise to normal motivation could be valuable in learning how disorde ...
21.
MH002652 (2014) Imaging of Neuropsychiatric Disorders with Developmental and Genetic Mechanisms
Karen F Berman, MD
The core aim of this project is to elucidate the nature, molecular foundations, underlying neurochemistry, and clinical correlates of neural systems-level dysfunction in schizophrenia. Toward that end, this year, the Section on Integrative Neuroimaging has successfully executed comprehensive, multi ...
22.
MH002666 (2014) Evaluation and Treatment of Obsessive Compulsive and Related Disorders
Susan Elizabeth Swedo, MD
Obsessive-compulsive disorder (OCD) affects 1-2% of children and adolescents, causing significant distress and impairments from the unrelenting obsessional thoughts and compulsive behaviors. A unique subgroup of children with OCD has been identified on the basis of the acuity of their symptom onset ...
23.
MH002685 (2014) Peptide Receptor Systems
Theodore B Usdin, MD, PhD
Investigation of the physiological functions of the neuropeptide Tuberoinfundibular Peptide of 39 residues (TIP39) and its receptor, the Parathyroid Hormone Receptor 2 (PTH2R) has been a recent focus of the section. These molecules were discovered in this laboratory several years ago. In previous pr ...
24.
MH002712 (2014) Characterization Of Neuropsychological Impairment In Schizophrenia
Karen F Berman, MD
Following are descriptions of our most significant work related to this project over the past year. Paragraphs 1-3 cover work that falls within the "phenomics" area described in our goals and objectives. Paragraphs 2 and 4 address heterogeneity reduction and subgrouping themes also described in the ...
25.
MH002717 (2014) Neuroimaging of Brain Circuits and Neurogenetic Mechanisms in Normal Cognition
Karen F Berman, MD
In pursuit of its long-standing commitment to characterizing the neurochemical, neurogenetic, and neuropsychological contributions to neural systems function and development relevant to mental illness, the Section on Integrative Neuroimaging (SoIN) has made tremendous progress in building two unprec ...
26.
MH002734 (2014) Genetic Basis Of Cortical Malfunction In Schizophrenia
Karen F Berman, MD
During FYI 2013-2014, a number of major accomplishments have driven this project closer to meeting its goals of quantifying schizophrenia- and schizophrenia-risk associated cortical dysfunction, identifying candidate genetic contributors to this dysfunction, and assessing the importance of these con ...
27.
MH002736 (2014) Neural Substrates Of Stimulus Recognition And Association Memory
Elisabeth Adams Murray, PhD
The prevailing model of amnesia holds that it depends on damage to a group of loosely related structures, collectively called the medial temporal lobe (MTL). One influential theory holds that these areas work together as a single functional unit. According to this theory, the structures in the MTL ...
28.
MH002768 (2014) Subcellular Compartmentilization of Neuronal Gene Expression
Barry Bernard Kaplan, PhD
Axons and nerve terminals are unique subcellular structures of the neuron that play a critical role in the development and maintenance of neural connectivity. One of the central tenets in neuroscience is that the protein constituents of these distal neuronal compartments are synthesized in the nerv ...
29.
MH002778 (2014) The Phenomenology And Neurophysiology Of Juvenile Bipolar Disorder
Ellen Leibenluft, MD
Since the beginning of this project we have screened over 2200 subjects for this study. We have enrolled approximately 135 youth with bipolar disorder (BD), 130 subjects at risk for BD because they have a parent or sibling with the illness, and 120 adults with BD. This year, approximately 20 new sub ...
30.
MH002781 (2014) fMRI Studies Of Pediatric Mood And Anxiety Disorders
Daniel Pine, MD
This work is conducted under protocol 01-M-0192, NCT is 00018057.
Through a series of three protocols, we are using functional magnetic resonance imaging (fMRI) to examine neurocognitive correlates of pediatric anxiety disorders. Through ongoing collaborative studies, we also have increasingly com ...
31.
MH002782 (2014) fMRI Studies Of Risk For Mood And Anxiety Disorders In Children
Daniel Pine, MD
This work is conducted under protocol 03-M-0186, NCT00060775.
In this project, our group is examining biological aspects of risk for mood and anxiety disorders in children. Such work has major public impact. By identifying biological risks in children, information on novel treatments and preventa ...
32.
MH002783 (2014) Functional MRI Method Development
Peter A Bandettini, BS, PhD
Protocol number 93-M-0170, NCT00001360
The Section on Functional Imaging Methods (SFIM) has advanced functional MRI (fMRI) methodology through development of processing and acquisition methods and research on the underlying mechanisms behind the fMRI signal. The ultimate goals are to grain a deep ...
33.
MH002784 (2014) Neurogenesis in the Adult Brain
Heather A Cameron, PhD
This project focuses on the interactions between experience and adult neurogenesis in the hippocampal region of the brain. We are interested in understanding how experiences, including learning or stressful experiences, regulate adult neurogenesis and how the new neurons alter responses to stress an ...
34.
MH002786 (2014) The Pathophysiology and Treatment Of Children With Severe Mood Dysregulation
Ellen Leibenluft, MD
As noted above, in response to the concern about the appropriate diagnosis for children with chronic, severe irritability, we defined a group of children whom we described as having severe mood dysregulation (SMD). These children have extremely severe irritability and symptoms of hyperarousal (the l ...
35.
MH002793 (2014) PET Radiopharmaceutical Sciences
Victor W Pike, PhD
The Molecular Imaging Branch (MIB) aims to exploit positron emission tomography (PET) as a radiotracer imaging technique for investigating neuropsychiatric disorders, such as autism, depression, addiction, schizophrenia and Alzheimer's disease (AD). Fundamental to this mission is the development of ...
36.
MH002794 (2014) Pediatric Brain Imaging
Jay Giedd, MD
A unifying theme emerging from our work is that in neuroimaging, as in life, the journey is often as important as the destination. Trajectories of brain morphometry, as opposed to snapshots in time, are more highly correlated with cognitive parameters, are better predictors of clinical outcome, and ...
37.
MH002795 (2014) Translational Evaluation Of PET Radiotracers
Robert Innis, MD
Several of the advisory groups with whom we work closely encouraged us to develop radioligands for glutamatergic targets. Here, we describe our ongoing work in animals and in healthy subjects for two such targets: metabotropic glutamate receptor 1 (mGluR1) and transmembrane AMPA receptor regulatory ...
38.
MH002797 (2014) Neuronal avalanches in the neocortex
Dietmar Plenz, PhD
1. Neuronal avalanches are increasingly recognized to be important for cortex function. My Section took the lead in organizing the first conference on Criticality in Neural Systems in collaboration with Ernst Niebur, Johns Hopkins University. In April 2012, the 2-day conference took place on the N ...
39.
MH002798 (2014) The Psychophysiology Of Fear And Anxiety
Christian Grillon, PhD
Our work focuses on two major research themes. One major theme is to elucidate normative mechanisms of fear and anxiety in healthy individuals and to identify which of these mechanisms are perturbed in anxiety disorders. Anxiety is an adaptive response to threat that enables organisms to rapidly and ...
40.
MH002800 (2014) Identifying Neural Substrates of Behavior in Drosophila Melanogaster
Benjamin H White, PhD
Ecdysis sequences are stereotyped motor programs that are used to cast off an insects exoskeleton at each molt and to expand a new exoskeleton to accommodate further growth. Survival and growth thus depend upon successful execution of ecdysis sequences, and each such sequence must be tailored to the ...
41.
MH002803 (2014) Magnetic Resonance Spectroscopy and Imaging Studies of Brain Functions
Jun Shen, PhD
The goals of this research are to develop advanced magnetic resonance spectroscopy (MRS) and imaging techniques and to apply them and other complementary methods to studying brain metabolism, neurotransmission and enzyme activity (protocol no. 11-M-0045, NCT no. 01266577; protocol no. 05-M-0144, NCT ...
42.
MH002804 (2014) Family Study of Affective and Anxiety Spectrum Disorders
Kathleen R Merikangas, PhD
The major aims of this project have been accomplished through the establishment of a large community based family study of adult probands who participate in comprehensive clinical and biologic assessments followed by comparable evaluations of their adult and child relatives. Recruitment of probands ...
43.
MH002806 (2014) National Comorbidity Survey - Replication (NCS-R)
Kathleen R Merikangas, PhD
The major analyses of the NCS-R dataset during this past year focus on comparisons between adolescent and adult patterns of psychopathology of mania. We have also shown that patterns of mania in adults and youth are remarkably similar. The manuscript is currently under review. In collaboration with ...
44.
MH002807 (2014) Zurich Cohort Study of Young Adults
Kathleen R Merikangas, PhD
During the past year, we have continued to analyze the data from this unique prospective cohort study that covers a total observation period of 30 years for this cohort of young adults who have been followed since the age of 18.
In collaboration with our colleagues in Zurich, we are preparing an ...
45.
MH002808 (2014) National Comorbidity Survey - Adolescent (NCS-A)
Kathleen R Merikangas, PhD
During the past year, we have continued to actively pursue analyses of topics relevant to the National Institute of Mental Health, Intramural Research Program mission such as anxiety disorders, attention deficit hyperactivity disorder (ADHD), mood disorders, sleep patterns and problems, service util ...
46.
MH002810 (2014) Functional genomics of bipolar disorder
Francis Joseph McMahon, MD
IRB Protocol 80-M-0083
NCT00001174
In order to better interpret the impact of genetic variation on the brain biology of bipolar disorder, we are pursuing a variety of functional genomics studies, including brain imaging, microarray gene expression and RNA-seq in post-mortem brain tissue, and ce ...
47.
MH002813 (2014) Cholinergic Modulation of Cognition and Emotion in Mood Disorders
Maura L Furey, PhD; Carlos Alberto Zarate, MD
This Report involves work collected under protocol 03-M-0108 (NCT00055575).
Clinical Studies:The role of cholinergic system in mood disorders has been highlighted recently through our demonstration that blocking cholinergic muscarinic activity with scopolamine produces rapid antidepressant effects. ...
48.
MH002828 (2014) Efficacy of an Antiglutamatergic Agents in Treatment-Resistant Depression
Carlos Alberto Zarate, MD
This Report involves work collected under protocols 03-M-0092 (NCT00054704) and 04-M-0222 (NCT00088699).
Novel targets for developing new treatments for treatment-resistant major depression are urgently needed. The glutamatergic system stands as an important to target to pursue in the developing ...
49.
MH002838 (2014) Neurophysiology of Visual Perception
David A Leopold, PhD
Primates including humans have the highest visual acuity of any mammalian species, second only to a few predatory birds in being able to resolve fine spatial detail. This fact reflects the predominant use of vision, as opposed to other senses such as olfaction, for interacting with the environment ...
50.
MH002843 (2014) Identification of Genes Involved in Major Mood Disorders
Francis Joseph McMahon, MD
IRB Protocol 80-M-0083
NCT00001174
Starting in 1993, in collaboration with 10 academic centers across the United States, we recruited a large sample of over 3,000 individuals with bipolar or related mood disorders. All participants did a diagnostic interview and provided a blood sample for DNA ...
51.
MH002844 (2014) Genetic Determinants of Antidepressant Response
Francis Joseph McMahon, MD
Strong evidence from family and twin studies demonstrates that major depressive disorder (MDD) is heritable, yet there has been limited progress in identifying the actual genes involved. A separate, perhaps overlapping set of genes is expected to play a role in individual variation in treatment resp ...
52.
MH002851 (2014) Generalized Anxiety Disorder and Social Anxiety Disorder:
Robert James Richard Blair, PhD
There were developments in two strands of our work with patients with GSP and GAD over the past 12 months:
The first concerns the specific nature of the functional impairment seen in GSP. In previous work, we have shown that GSP does not simply represent a heightened amygdala response to social t ...
53.
MH002852 (2014) Clinical Evaluation of PET Radiotracers
Robert Innis, MD
Examples of progress made during the prior year are summarized below.
1) Building on prior work, we found increased translocator protein (TSPO), a putative biomarker of neuroinflammation, in patients with temporal lobe epilepsy (TLE) extending beyond the seizure focus and involving bilateral regi ...
54.
MH002857 (2014) Glutamatergic Modulators for Rapid & Sustained Antidepressant Effect
Carlos Alberto Zarate, MD
This Report involves work collected under protocol 04-M-0222 (NCT00088699).
Our research suggests that the glutamatergic system is involved in the mechanism of action of antidepressants. We found that the non-competitive NMDA antagonist (ketamine) resulted in rapid, robust and relatively sustaine ...
55.
MH002860 (2014) Emotional dysfunction and childhood behavioral disturbance
Robert James Richard Blair, PhD
This project has established a series of core neuro-biological findings regarding the basis of Conduct Disorder (CD), particularly CD with Callous-Unemotional (CU) traits (reduced guilt and empathy). Over the past year, our main achievements have been the following:
First, in a series of studies ...
56.
MH002863 (2014) Multimodal Neuroimaging of Gene-Brain Relationships in Williams Syndrome
Karen F Berman, MD
Employing incisive, multimodal neuroimaging methodologies to study individuals with WS and related genetic variation in the WS critical region, the Section on Integrative Neuroimaging has vigorously pursued its mission of elaborating clinically meaningful, specific genetic contributions to brain str ...
57.
MH002865 (2014) Reproductive Endocrine Related Mood Disorders-Differential Sensitivity
Peter J Schmidt, MD
The protocols involved in this project are as follows: 00-M-0103, 03-M-0138, 03-M-0161, 04-M-0139, 05-M-0059, 81-M-0126, 90-M-0088, 92-M-0174, and 95-M-0097. This report includes work arising from the following protocols: NCT00005011, NCT00056901, NCT00059228, NCT00082043, NCT00100360, NCT00001177, ...
58.
MH002868 (2014) Clinical and Behavioral Phenotyping of Autism and Related Disorders
Susan Elizabeth Swedo, MD
Autism is currently defined as a single disorder characterized by impairments in social communication and the presence of restricted interests and repetitive behaviors. However, there is mounting evidence that autism represents a collection of overlapping neurodevelopmental disorders, resulting fro ...
59.
MH002870 (2014) National Health And Nutrition Examination Survey (NHANES)
Kathleen R Merikangas, PhD
During the past year we have investigated the prevalence and clinical correlates of attention deficit hyperactivity disorder (ADHD) under the definitions of DSM-IV and DSM-5 using NHANES/CDISC data. The results showed that extension of the age-of-onset criterion from 7 to 12 years lead to about a 30 ...
60.
MH002874 (2014) The Neuroregulatory Effects of Gonadal Steroids in Humans
Peter J Schmidt, MD
The protocols involved in this project are as follows: 05-M-0059, 81-M-0126, and 92-M-0174.This report includes work arising from the following protocols: NCT00026832, NCT00100360, NCT00001177, and NCT00001322.
Behavioral observations show that clinically significant depressive symptoms are rare a ...
61.
MH002881 (2014) Molecular mechanisms of synapse development and plasticity
Zheng Li, PhD
1. A non-apoptotic function of the mitochondria-caspase cascade in presynaptic site development
Caspase-3 is an effector caspase that can execute cell death in apoptosis (a form of programmed cell death). Our previous research shows that caspase-3 also has a non-apoptotic function in postsynaptic ...
62.
MH002882 (2014) Characterizing the function of miRNAs in neural development, synaptic plasticity and schizophrenia.
Zheng Li, PhD
1. The role of miRNAs in long-lasting synaptic plasticity.
microRNAs (miRNAs) are short, non-coding RNAs that bind to mRNAs to inhibit translation and/or promote mRNA degradation. Each miRNA can potentially target to hundreds of distinct mRNAs, and thousands of genes are regulated by miRNAs. miRNAs ...
63.
MH002886 (2014) Neural mechanisms of reward processing and emotion
Elisabeth Adams Murray, PhD
Although neurophysiological studies have shown that the activity of neurons in the amygdala, OFC and MFC correlates with the value of expected feedback, such as rewarding or aversive events, little is known about the physiological interactions among these areas or how these interactions produce emot ...
64.
MH002887 (2014) Neural substrates of reward processing and emotion
Elisabeth Adams Murray, PhD
Previous work on this project has shown that value-based decision making requires both the OFC and the amygdala. We have used two kinds of tasks to investigate their mechanisms: (1) standard probabilistic and deterministic 2- and 3-choice visual discrimination learning tasks and (2) tasks that requi ...
65.
MH002890 (2014) Integrating EEG/MEG and fMRI: 99-M-0172
Richard Coppola, SB, DSc
Our earlier basic studies have shown that MEG recordings during cognitive tasks have the ability to localize brain activity in comparable fashion to functional MRI. Specifically reductions in of power in the beta frequency band at the cortical level has been found to agree with BOLD activation resul ...
66.
MH002893 (2014) Learning and plasticity in the human brain
Christopher Ian Baker, PhD
The primary goals of this research are i) to establish differences in brain processing in the context of nervous system damage or dysfunction, and ii) to determine the potential for learning-induced plasticity to ameliorate the negative consequences of such changes. Over the past year we have primar ...
67.
MH002896 (2014) The Neural Basis of Functional MRI Responses
David A Leopold, PhD
There is a range of approaches to understanding how fMRI signals can be understood in terms of underlying neural data. In some laboratories, experiments are aimed at carefully determining what types of neurons and molecules serve as the actual mediators for regulating blood flow. Such experiments ...
68.
MH002897 (2014) Molecular and Cellular Mechanisms of Experience-Dependent Cortical Processing
Kuan Hong Wang, PhD
Our brain can be considered as a type of information processing system like a computer, where input signals need to be first detected and properly represented, then integrated for decision-making and output control. A unique feature of the brain as an information processing system lies in its adapt ...
69.
MH002898 (2014) Social processing and neural plasticity
David A Leopold, PhD
There are countless mechanisms by which the brain learns, with the fundamental unit of learning expressed at the synapse. In vitro studies can track the changing strength of synapses based on principles of coordinated presynaptic and postsynaptic activity. Many of the principles of neural learning ...
70.
MH002909 (2014) Object, face, body and scene representations in the human brain
Christopher Ian Baker, PhD
The goal of this research is to understand how we see what we see: how does the brain analyze the light falling on the retina of the eye to encode a world full of objects, people and things?
During the past year we have continued to investigate 1) the interaction between bottom up (sensory drive ...
71.
MH002914 (2014) Treatment of Medical Conditions among Individuals with Autism Spectrum Disorders
Susan Elizabeth Swedo, MD
Autism spectrum disorders are defined by deficits of social-communication and the presence of restrictive and/or repetitive behaviors. Recent epidemiologic studies have documented an increase in the number of children identified with autism spectrum disorder (ASD) over the past decade and according ...
72.
MH002915 (2014) Neuroimmunologic Investigations of Autism Spectrum Disorders (ASD)
Susan Elizabeth Swedo, MD
Autism is defined by its behavioral manifestations: social-communication deficits and the presence of restricted or repetitive behaviors. The cause of these abnormalities is unknown, but it is strongly suspected that autism spectrum disorders (ASD) result from a combination of genetic and environme ...
73.
MH002917 (2014) Office of the Scientific Director
Susan G Amara, PhD
The NIMH Division of Intramural Research Programs' (DIRP) scientists conduct research ranging from studies into the mechanisms of normal brain function, conducted at the behavioral, systems, cellular, and molecular levels, to clinical investigations into the diagnosis, treatment and prevention of me ...
74.
MH002918 (2014) Functional Anatomy of Face Processing in the Primate Brain
Leslie G Ungerleider, PhD
Lesions of the inferior temporal (IT) cortex in humans can result in the clinical syndrome termed prosopagnosia, an inability to recognize familiar faces. Single-cell recordings from IT cortex of monkeys have revealed the existence of neurons that are selectively activated by visual images of faces. ...
75.
MH002920 (2014) The Cognitive Neuroscience of Autism Spectrum Disorders
Alex Martin, PhD
This past year we have continued to evaluate the behavioral consequences, and associated neural characteristics, of Autism Spectrum Disorders (ASD).
The presence of intense and idiosyncratic interests and hobbies has long been recognized as one of the defining clinical features of ASD. We docum ...
76.
MH002922 (2014) Psychiatry Consultation Liaison Service Research
Maryland Pao, MD
The NIMH Psychiatric Consultation Liaison Service (PCLS) provides important psychiatric services to the many constituencies of the NIH. While providing such services to the NIH Community, PCLS clinicians conduct research and collaborate with NIH investigators by providing expertise in the areas of p ...
77.
MH002927 (2014) Neurobiology and Target validation of novel therapeutic agents in mood disorders
Carlos Alberto Zarate, MD
This Report involves work collected under protocols 08-M-0196 (NCT00759395); 08-M-0150 (NCT00697268); 14-M-0085 (NCT02122562); 14-M-0041 (NCT02049385); and 07-M-0152 (NCT00472576).
Results this past year:
1) Increased fear-potentiated startle in major depressive disorder patients with lifetime h ...
78.
MH002928 (2014) Frontal striatal systems and dopamine in normal and pathological behavior
Bruno B Averbeck
Our lab uses a combination of neurophysiology, pharmacology and functional imaging to examine the role of frontal striatal systems in behavior. Several of our experiments are motivated by studies in patient groups that show that patients have deficits on particular tasks. We then study those tasks ...
79.
MH002929 (2014) Developing new statisical methods to detect rare variants involved in neuropsychiatric disorders
Yin Yao Shugart, PhD
We developed one analytical tool and published our results in peer-reviewed journals.
We developed a haplotype-based approach(H-PDT) to analyze rare variants within pedigrees with complex human disorders. Extensive simulations in the sequencing setting were carried out to evaluate and compare the ...
80.
MH002930 (2014) Developing Stats Methods to Detect Rare Genetics Variants in Human Complex Pedigrees
Yin Yao Shugart, PhD
We have developed pedigree-based rare variants analysis approach by treating each affected relatives as dependent pairs and the dependency will be accounted for using correlation matrix. This work led to two publications. We are now working on using a haplotype-based approach to identify causal vari ...
81.
MH002931 (2014) Neurodevelopmental Genomics Study, University of Pennsylvania
Kathleen R Merikangas, PhD
The NIMH team has collaborated with the U PENN team on assessment and data analysis of emotional and behavioral conditions in children enrolled in the Neurodevelopmental Genomics Study. During the past year, the NIMH team has collaborated with the U PENN and CHOP investigators to facilitate data ana ...
82.
MH002932 (2014) Cohort study of Lausanne (COLAUS) on cardiovascular diseases and depression
Kathleen R Merikangas, PhD
The collection of data from this cohort has now been completed and analyses of the data are now underway. The National Institute of Mental Health (NIMH) Family Study of Affective Spectrum Disorders has included numerous comparable measures of psychiatric and cardiovascular phenotypes that can be ana ...
83.
MH002933 (2014) Endocrine and Neurobiologic Events Accompanying Puberty
Peter J Schmidt, MD
The protocol involved in this project is 11-M-0251. This report includes work arising from the following protocol: NCT01434368.
Recruitment for this demanding longitudinal study is in its early stages due in part to the successful development of imaging techniques required to measure gonadal volume ...
84.
MH002934 (2014) Analyzing fMRI and next-generation-sequenced data for schizophrenia biomarkers
Yin Yao Shugart, PhD
Part 1. For our initial analysis, we parcellated the whole brain into 116 anatomic regions and 1000 functional networks, then analyzed connectivity within and among brain regions and networks. To test our results, we analyzed the same data using a multivariate classification method, which confirmed ...
85.
MH002935 (2014) Mathematical and Statistical Analysis Techniques for in Vivo Imaging Studies
Carolyn E Beebe, PhD
The protocols involved in this project are 06-M-0214 (NCT00362843) and 09-M-0123 (NCT00884702.
We have refined our analysis methods for estimation of rates of cerebral protein synthesis (rCPS) with L-1-11Cleucine and PET. Because changes in rCPS tend to be modest, it is essential that kinetic anal ...
86.
MH002936 (2014) Cerebral Protein Synthesis During Sleep and Memory Consolidation
Carolyn E Beebe, PhD
The protocol involved in this project is 09-M-0123, NCT00884702.
During the 2014 funding period, we addressed the following:
In collaboration with T.Balkin from the Walter Reed Army Institute of Research, we use the L-1-11Cleucine PET method to measure rCPS in human subjects during sleep. To ...
87.
MH002940 (2014) Pathophysiological Mechanisms in Major Depression and Bipolar Disorder
Philip William Gold, MD
Aim 1.
1A. We hypothesize that the premature coronary artery disease, diabetes and stroke of MDD occur as a consequence of the metabolic syndrome in patients with MDD secondary to the CNS changes that promote the cognitive and mood components of MDD. Although the metabolic syndrome occurs in the ge ...
88.
MH002942 (2014) Multimodal imaging: genetic and environmental effects in neuropsychiatry
Karen F Berman, MD
The group has continued to make strides in imaging genetics in healthy volunteers, patients with schizophrenia and their unaffected siblings. Using fMRI, Callicott et al. (J Clin Invest., 2013) extended findings from a previous and novel translational experiment regarding genetic factors that regula ...
89.
MH002946 (2014) Structure, function and pharmacology of neurotransmitter reuptake systems
Susan G Amara, PhD
Our laboratory has shown that amphetamines trigger the internalization of the dopamine transporter (DAT) by a series of intracellular events that are distinct from the generally established actions of amphetamines to inhibit dopamine (DA) uptake or to increase DA efflux. We have found that when appl ...
Scientific Core
1.
MH002884 (2014) Functional MRI Core Facility
Peter A Bandettini, BS, PhD
Space Utilization:
The Functional MRI Facility (FMRIF) currently occupies approximately 4800 sq. ft of space, divided between the scanner bays, control rooms and electronics/machine rooms for 3TA, 3TB, 3TC, 3TD, and 7T MRI scanners located within the NMR center and office space on the second floo ...
2.
MH002888 (2014) Scientific and Statistical Computing Core
Robert Cox, PhD
The main mission of the Core is to help NIH researchers with analyses of their functional MRI (brain activation mapping) data. Along the way, we also help non-NIH investigators, mostly in the US but also some abroad. Several levels of help are provided, from short-term immediate aid to long-term dev ...
3.
MH002889 (2014) NIMH MEG Core Facility
Richard Coppola, SB, DSc
The MEG Core staff works interactively with an extensive group of PI's in NIMH, NINDS and NIDCD for study design, task development, acquisition protocols, signal processing and data analysis. Procedures have been setup for data security, transfer and storage. We have worked with the Scientific and S ...
4.
MH002894 (2014) Magnetic Resonance Spectroscopy Core Facility
Jun Shen, PhD
As a noninvasive method for measuring concentration and distribution of chemicals in the living brain MRS is an important tool for studying brain function and disorders. However, robust measurement of MRS signals requires highly sophisticated design, implementation and maintenance of various MRS tec ...
5.
MH002899 (2014) Neurophysiology Imaging Facility Core: Functional and Structural MRI
David A Leopold, PhD
At the NIH, the Neurophysiology Imaging Facility is a core facility dedicated to the MRI scanning of nonhuman primates. The NIF, which was founded in 2004, offers services to a wide range of investigators in each of the three sponsoring institutes (NIMH, NINDS, and NEI). These services assist in t ...
6.
MH002901 (2014) Transgenic resources for neuroscience research
James M Pickel, AB, PhD
The NIMH transgenic core facility has several major functions: 1) to produce transgenics for neuroscience research, 2) support research with associated techniques in genetic research in neuroscience, 3) develop new transgenic techniques and model systems and 4) engage in collaborative projects that ...
7.
MH002903 (2014) Procurement and Characterization of Postmortem Brain Tissue
Barbara K Lipska, PhD
From July 11, 2013 August 20, 2014, we collected 77 brains through the DC and VA Medical Examiners Offices. During this time, part of the brain collection was transferred to the Lieber Institute on Brain development (LIBD) as part of the Material Transfer Agreement (MTA) and as a result the total n ...
8.
MH002911 (2014) NIMH Instrumentation Core Facility
George Raphael Dold, MME, BSEE
Summary: This past year, our Section had the unique opportunity to support the research from more than 46 different Labs & Sections within NIMH, NINDS, NICHD, and NCAAM. During the past twelve months, investigators from these labs and branches requested 472 formal projects from our staff. This is ...
9.
MH002943 (2014) NIMH-NINDS Clinical Proteomics Unit
Jeffrey A Kowalak, PhD
The NIMH-NINDS Clinical Proteomics Unit (CPU) was established on June 1, 2013, as part of the NINDS Translational Neuroscience Center. Our mission is to provide clinical investigators with access to state-of-the-art mass spectrometry instrumentation and evolving proteomics technologies. We are pursu ...
Clinical Support Services
1.
MH002912 (2014) Office of the Clinical Director
Maryland Pao, MD
CLINICAL RESEARCH SUPPORT: The NIMH OCD is responsible for many critical clinical, administrative, and research-related support services including: 1) administrative oversight and quality performance improvement of NIMH inpatient units and outpatient clinic through monitoring of high risk protocols, ...
Clinical Training
1.
MH002939 (2014) Office of the Clinical Director-Psychiatry Clinical Research Training
Maryland Pao, MD
Clinical Fellowship Programs:
In FY14, there were fourteen NIMH IRP clinical fellows. Of the fourteen fellows, one is a PGY-4 resident in the ACGME accredited program. Three trainees were new recruits who came from top residencies in the U.S. They included three women one of whom is an MD-PhD a ...
Animal Research Infrastructure
1.
MH002924 (2014) Veterinary Medicine Research Branch
James Raber, DVM, PhD
The NIMH Veterinary Medicine Research Branch (VMRB) has successfully provided veterinary medical, husbandry and research support to over twenty-eight (28) principal investigators in the NIMH IRP with over fifty-seven (57) active animal study protocols. In addition, the Branch has provided training a ...
New Space Activation & Commissioning
1.
MH002945 (2014) Porter Neuroscience Research Center- NIMH DIRP Programs
Susan G Amara, PhD
The Porter Neuroscience Center (PRNC II) is complete and occupation was achieved in FY2014. The facility houses NIH intramural neurosciences programs of several NIH institutes, including NIMH, NINDS, NICHD, NEI, NIDCR, NIDCD, NIA, NCCAM and NIBIB.
Composed of five floors (basement, ground, 1st, ...
Education and Outreach
1.
MH002916 (2014) Office Of Fellowship Training
Janet Elizabeth Clark
In fiscal year (FY) 2014 the Office of Fellowship Training (OFT) organized and managed several educational events and programs for the DIRP including several new training opportunities recently added to the OFT portfolio. All of the OFT-sponsored events were done to service the needs of a multidisc ...
Technology Transfer
1.
MH002925 (2014) Office of Technology Transfer
Suzanne L Winfield, PhD
The Office of Technology Transfer (OTT) negotiates Material Transfer Agreements, Cooperative Research Development Agreements, Confidential Disclosure Agreements, Clinical Trial Agreements, etc. We also provide guidance and assistance to NIMH researchers, evaluate employee inventions for their patent ...


{% set title = "Being a designer at IBM | Alessio Laiso" %} {% set description = "In 2012 IBM started shifting its corporate culture towards a focus on users’ outcomes and design thinking. These are some thoughts about my role at IBM, and how my team and I are contributing to the transformation of the company." %} {% extends "portfolio/_layout.html" %} {% block content %}
In 2012 - 101 years after its foundation - IBM started a deep corporate culture renovation, shifting towards a focus on users’ outcomes and design thinking. These are some thoughts about my role at IBM, and how my team and I are contributed to the transformation of the company.
IBM
Jan 2016–May 2017
As a designer in the IBM Security team, most of the software I worked on was in the complex space of
cybersecurity. What I did here was a combination of both conceptual work that influences the vision and
strategy of the IBM Security ecosystem, and more tactile Agile sprints. Designing for the highly specialized
users who use our products makes it hard to guess what features would work well, and highlights the
importance of design research.
Together with my team, I helped lead and define research objectives,
conduct secondary research (articles about the space, competitor analysis, etc.), and run many rounds of
user interviews. These interviews helped us find the real pain points of our users, validate our
assumptions, and test the usability of our designs. We also had regular checkpoints with our stakeholders
and subject matter experts to make sure our solutions were feasible and to improve them at each iteration.
“We know what (features) we want” is an attitude that can easily lead teams to forget what the users really
need. Part of what I feel is our job as ambassadors of design in a large enterprise is getting the whole
team to fully understand the value of design thinking.
IBM operates in diverse, multidisciplinary teams, which are often distributed in multiple locations and time
zones. Getting an engineer on the other side of the Atlantic to trust “these designers” telling him how to
make software in spite of his many years of experience can seem a daunting task. Indeed, at first some
people might feel uncomfortable trying out new methodologies. What I’ve found is that, if you work together
with the right spirit, eventually they’ll not only appreciate your work and the results the team is getting,
but also start to explicitly request your help for new projects.
When it came to visual design, as a designer in IBM Security I used both the IBM Design Language and the IBM Security Design Guide. Both these resources were living languages: I often prototyped, tested, and discussed new patterns with the rest of the team to further refine our tools. In addition to this, my passion for typography and semi-obsession for baseline grids and pixel perfection always made me very happy to talk anything related to visual design.
With so much going on in design at IBM, there were many opportunities to share knowledge and tell the tale — if you were willing to. I've had the pleasure to lead many design thinking workshops for a range of people that goes from IBM engineers to 15-year-old students. I also had the chance to be a speaker at a couple of conferences. At UX Ireland, I presented a study I conducted about how typography can influence user experience, and I was overwhelmed with the response. You can read the key findings from the study in this Medium story.
For over 20 consecutive years, IBM has been topping the annual list of U.S. patent recipients (yes, IBMers are quite smart). Designers at IBM are also making their contribution, and two invention disclosures I worked on with my team have been published on ip.com (you can check them out here and here).


This is my car.
Awesomeness completed 60%
Imagine 355 horses simultaneously. That`s my car sounds
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With my car I can go anywhere. That`s how my car sounds
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§378-67 Compensation for employee participation in investigation, hearing, or inquiry. This subpart shall not be construed to require an employer to compensate an employee for participation in an investigation, hearing, or inquiry held by a public body in accordance with section 378-62 of this subpart. [L 1987, c 267, pt of §1; am L 2011, c 166, §9]


Brain properties predict proximity to symptom onset in sporadic Alzheimer's disease. Vogel JW, Vachon-Presseau E, Pichet Binette A, Tam A, Orban P, La Joie R, Savard M, Picard C, Poirier J, Bellec P, Breitner JCS, Villeneuve S; Alzheimer’s Disease Neuroimaging Initiative and the PREVENT-AD Research Group. Brain. 2018 Apr 23.
doi: 10.1093/brain/awy093.Bi-directional Association of Cerebrospinal Fluid Immune Markers with Stage of Alzheimer’s Disease Pathogenesis. Meyer PF, Savard M, Poirier J, Labonté A, Rosa-Neto P, Weitz TM, Town T, Breitner, J; Alzheimer’s Disease Neuroimaging Initiative; PREVENT-AD Research Group. J Alzheimers Dis. 2018 Apr 11.
doi: 10.3233/JAD-170887.Subjective cognitive decline is associated with altered Default Mode Network connectivity in individuals with a family history of Alzheimer’s Disease, Verfaillie SCJ, Pichet Binette A, Vachon-Presseau E, Tabrizi S, Savard M, Bellec P, Ossenkoppele R, Scheltens P, van der Flier WM, Breitner JC, Villeneuve S for the PREVENT-AD Research Group. Biological Psychiatry: Cognitive Neurosciences and Neuroimaging. May 2018.
doi: 10.1016/j.bpsc.2017Proximity to Parental Symptoms Onset and Amyloid-β Burden in sporadic Alzheimer disease. Villeneuve S, Vogel JW, Gonneaud J, Pichet Binette A, Rosa-Neto P, Gauthier S, Bateman RJ, Fagan AM, Morris JC, Benzinger TL, Johnson SC, Breitner JC, Poirier J, for the Prevent-AD group. JAMA Neurology. 2018 May 1.
doi: 10.1001/jamaneurol.2017.5135.Regionally specific changes in the hippocampal circuitry accompany progression of cerebrospinal fluid biomarkers in preclinical Alzheimer’s disease, Tardif CL, Devenyi G, Amaral RSC, Pelleieux S, Poirier J, Rosa-Neto P, Breitner J, Chakravarty MM; PREVENT-AD Research Group., Hum Brain Mapp. 2017 Nov 21.
doi: 10.1002/hbm.23897Deficit in Central Auditory Processing as a Biomarker of Pre-Clinical Alzheimer’s Disease, Tuwaig, Miranda, Savard, Mélissa, Jutras, Benoît, Judes Poirier, Louis Collins, Pedro Rosa-Neto, David Fontaine and John C.S. Breitner for the PREVENT-AD Research Group, Journal of Alzheimer's Disease, vol. 60, no. 4, pp. 1589-1600, 21 Aug 2017.
doi: 10.3233/JAD-170545Validation of a Regression Technique for Segmentation of White Matter Hyperintensities in Alzheimer's Disease. Dadar M, Pascoal TA, Manitsirikul S, Misquitta K, Fonov VS, Tartaglia MC, Breitner J, Rosa-Neto P, Carmichael OT, Decarli C, Collins DL. IEEE Trans Med Imaging. 2017 Aug;36(8):1758-1768.
doi: 10.1109/TMI.2017.2693978Odor identification as a biomarker of preclinical AD in older adults at risk. Lafaille-Magnan ME, Poirier J, Etienne P, Tremblay-Mercier J, Frenette J, Rosa-Neto P, Breitner JCS; PREVENT-AD Research Group. Neurology. 2017 Jul 25;89(4):327-335.
doi: 10.1212/WNL.0000000000004159Alzheimer’s Progression Score’: Development of a Biomarker Summary Outcome for AD Prevention Trials J.-M. Leoutsakos, A.L. Gross , R.N. Jones, M.S. Albert, J.C.S. Breitner (2016) The Journal of Prevention of Alzheimer’s Disease - JPAD© Volume 3, Number 4, 2016.
doi: 10.14283/jpad.2016Rationale and Structure for a new Center for Studies on Prevention of Alzheimer’s Disease (StoP-AD) J.C.S. Breitner, J. Poirier, P.E. Etienne1, J.M. Leoutsakos for the PREVENT-AD Research Group (2016) The Journal of Prevention of Alzheimer’s Disease - JPAD© Volume 3, Number 4, 2016.
doi: 10.14283/jpad.2016.121.Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer's disease. Orban P, Madjar C, Savard M, Dansereau C, Tam A, Das S, Evans AC, Rosa-Neto P, Breitner JC, Bellec P; PREVENT-AD Research Group. Sci Data. 2015 Oct 13;2:150043.
doi: 10.1038/sdata.2015.43.INTREPAD: a randomized trial of naproxen to slow progress of pre-symptomatic Alzheimer’s disease, Pierre François Meyer*, MSc; Jennifer Tremblay-Mercier*, MSc; Jeannie Leoutsakos, PhD; Cécile Madjar, MSc; Marie-Élyse Lafaille-Maignan, PhD; Melissa Savard, MSc; Pedro Rosa-Neto, MD, PhD; Judes Poirier, PhD**; Pierre Etienne, MD**; John Breitner, MD, MPH** for the PREVENT-AD research group. Neurology, 2019 Apr 5 [Epub ahead of print].
doi: 10.1212/WNL.0000000000007232.


As you walk into the office, the Branch Manager motions for you to sit down as he rounds his desk and sits down behind it. "Now, why did Meline send you?" He asks.
 "Canning?" The Branch Manager repeats, obviously confused.  You say it all as one long sentence.
"I see," he says when you finish."Well, it seems to me that you need to talk to our Culinary Arts Coordinator. We can go..." Before he can finish, his phone rings. He answers it then cups the mouthpiece. "I'm sorry," he whispers. "This is kinda important. If you go back out and take two lefts, she should be in the kitchen."
 "Wait," he whispers with urgency before you can leave.  Thanks."


Thanks so much for volunteering to write
about up a recap of our unconference session on up a recap of our your passion talk on (and for all your great contributions at camp!)
.
Here’s how to get started (and finished):
Please send us your Medium username so that we can add you as a writer to the Offline Camp Medium publication. If you haven't used Medium before, note that you can sign in with another social media account to get started. (Try clicking the extra Sign In button for more social media network options.)
Below you'll find links to any session audio, video, notes, or pics available, which you can use to jog your memory as needed.
Feel free to write as short or as long a story as you’d like.
You can find examples of other session recap posts in our Medium publication.
Once finalized, your passion talk video will be shared on our YouTube channel and embedded in your Medium post. You can find examples of other passion talk postshere.
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Please add the tag “Offline First,” as well as any other relevant tags for your topic, to your story using these instructions.
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you'll be able to add your draft post to the Offline Camp publication using these instructions when you're ready. (Don't worry, that won't actually publish your article, just make it available to our editorial team for review.)
Please let me know when you expect to be able to submit your draft. We’ve found that it's easiest to write within the first couple of weeks after Offline Camp while things are fresh in your memory.
Here are the resources you can use to jog your memory:


Leading Indicators Don't Point To The 'All Clear' Sign (Podcast)
by SA Marketplace Roundtable PodcastSummary
- Eric Basmajian of EPB Macro Research discusses his approach to identifying inflection points in the economic cycles.
- Leading indicators pertaining to industrial activity in the US prevents Basmajian from giving the "all clear" sign on full "risk on" allocating.
- There are some bright spots, chiefly housing and consumption, spurred by lower interest rates.
- The market is underestimating the risks of slowing manufacturing, however. Investors should allocate to the short end of the curve for now, which still has some upside.
Listen and subscribe to the Marketplace Roundtable on these podcast platforms:
Eric Basmajian rejoins the Marketplace Roundtable Podcast to discuss his investing experience as reflected in the EPB Macro Research service.
Basmajian's approach is to separate the economy into two main phases: periods where growth is accelerating versus periods where growth is decelerating. "What's nice about that approach is it's pretty objective," says Eric. "There's no opinion in an acceleration or a deceleration; it's more of a fact-based characterization."
During periods when growth is decelerating, his approach is to adopt a defensive investment posture characterized by an overweight allocation to fixed income and defensive stocks such as utilities, health care, and consumer staples. When growth accelerates, Eric over-allocates to more cyclical, risk-sensitive stocks and away from fixed income.
How to correctly identify the inflection points in the economic cycle? EPB uses a process of leading indicators and then adopts its investment approach based on these metrics. Right now, "the market is starting to try to shift to a stage of acceleration," marked by an outperformance of cyclical assets.
But the leading indicators do not corroborate this sentiment. "We still have an industrial slowdown," which carries its own sets of risks, specifically employment. Here, leading indicators "are actually moving to the lowest growth rate since 2009." The loss of jobs, particularly in manufacturing, is preventing EPB from assigning the "all clear" signal for buying risk assets.
To navigate these risks, investors should allocate to the short-end of the yield curve. There are several short-term Treasury ETFs that can accomplish this. Industrial and material stocks should best be avoided, as should shares of cyclical companies.
Contents:
- 2:15 - Discuss your approach to investing
- 4:00 - What's our status in the current cycle?
- 6:45 - What about the argument that manufacturing is not as important anymore?
- 9:45 - Is there any hope for a resurgence in manufacturing?
- 11:30 - Important leading indicators
- 17:00 - Outlook for interest rates and global growth
- 24:15 - Concerns about the market/portfolio
- 29:45 - Recommended investments
Disclosure: I am/we are long IEI, SHY, TLT, EBB, SPY, XLU, GLD. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.
Additional disclosure: Nathaniel Baker has no positions in any of the securities mentioned on this podcast.


@* * Copyright 2010-2013 Artima, Inc. * * Licensed under the Apache License, Version 2.0 (the "License"); * you may not use this file except in compliance with the License. * You may obtain a copy of the License at * * http://www.apache.org/licenses/LICENSE-2.0 * * Unless required by applicable law or agreed to in writing, software * distributed under the License is distributed on an "AS IS" BASIS, * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied. * See the License for the specific language governing permissions and * limitations under the License. *@ @import controllers.Application.milestoneScaladoc @import controllers.Application.milestoneVersion @userGuidePage("Using assertions") {
ScalaTest @milestoneVersion includes a domain specific language (DSL) for writing browser-based tests using Selenium.
To use ScalaTest's Selenium DSL, mix trait WebBrowser
into your test class. This trait provides the DSL in its
entirety except for one missing piece: an implicit org.openqa.selenium.WebDriver
. One way to provide the missing
implicit driver is to declare one as a member of your test class, like this:
class BlogSpec extends FlatSpec with ShouldMatchers with WebBrowser { implicit val webDriver: WebDriver = new HtmlUnitDriver val host = "http://localhost:9000/" "The blog app home page" should "have the correct title" in { go to (host + "index.html") pageTitle should be ("Awesome Blog") } }
For convenience, however, ScalaTest provides a WebBrowser
subtrait containing an implicit WebDriver
for each
driver provided by Selenium.
Thus a simpler way to use the HtmlUnit
driver, for example, is to extend
ScalaTest's HtmlUnit
trait, like this:
class BlogSpec extends FlatSpec with ShouldMatchers with HtmlUnit { val host = "http://localhost:9000/" "The blog app home page" should "have the correct title" in { go to (host + "index.html") pageTitle should be ("Awesome Blog") } }
The web driver traits provided by ScalaTest are:
| Driver | WebBrowser subtrait |
|---|---|
| Google Chrome |
Chrome
|
| Mozilla Firefox |
Firefox
|
| HtmlUnit |
HtmlUnit
|
| Microsoft Internet Explorer |
InternetExplorer
|
| Apple Safari |
Safari
|
You can ask the browser to retrieve a page (go to a URL) like this:
go to "http://www.artima.com"
Note: If you are using the page object pattern, you can also go to a page using the Page
instance, as
illustrated in the section on page objects below.
Once you have retrieved a page, you can fill in and submit forms, query for the values of page elements, and make assertions.
In the following example, selenium will go to http://www.google.com
, fill in the text box with
Cheese!
, press the submit button, and wait for result returned from an AJAX call:
go to "http://www.google.com" click on "q" textField("q").value = "Cheese!" submit() // Google's search is rendered dynamically with JavaScript. eventually { title should be ("Cheese! - Google Search") }
In the above example, the "q"
used in “click on "q"
” and “textField("q")
”
can be either the id or name of an element. ScalaTest's Selenium DSL will try to lookup by id first. If it cannot find
any element with an id equal to "q"
, it will then try lookup by name "q"
.
Alternatively, you can be more specific:
click on id("q") // to lookup by id "q" click on name("q") // to lookup by name "q"
In addition to id
and name
, you can use the following approaches to lookup elements, just as you can do with
Selenium's org.openqa.selenium.By
class:
xpath
className
cssSelector
linkText
partialLinkText
tagName
For example, you can select by link text with:
click on linkText("click here!")
If an element is not found via any form of lookup, evaluation will complete abruptly with a TestFailedException
.
ScalaTest's Selenium DSL provides a clear, simple syntax for accessing and updating the values of input elements such as text fields, radio buttons, checkboxes, and selection lists. If a requested element is not found, or if it is found but is not of the requested type, an exception will immediately result causing the test to fail.
You can change a text field's value by assigning it via the =
operator, like this:
textField("q").value = "Cheese!"
And you can access a text field's value by simply invoking value
on it:
textField("q").value should be ("Cheese!")
If the text field is empty, value
will return an empty string (""
).
You can use the same syntax with text areas by replacing textField
with textArea
, as in:
textArea("body").value = "I saw something cool today!" textArea("body").value should be ("I saw something cool today!")
Radio buttons work together in groups. For example, you could have a group of radio buttons, like this:
<input type="radio" name="group1" value="Option 1"> Option 1</input> <input type="radio" name="group1" value="Option 2"> Option 2</input> <input type="radio" name="group1" value="Option 3"> Option 3</input>
You can select an option in either of two ways:
radioButtonGroup("group1").value = "Option 2" radioButtonGroup("group1").selection = Some("Option 2")
Likewise, you can read the currently selected value of a group of radio buttons in two ways:
radioButtonGroup("group1").value should be ("Option 2") radioButtonGroup("group1").selection should be (Some("Option 2"))
If the radio button has no selection at all, selection
will return None
whereas value
will throw a TestFailedException
. By using value
, you are indicating you expect a selection, and if there
isn't a selection that should result in a failed test.
A checkbox in one of two states: selected or cleared. Here's how you select a checkbox:
checkbox("cbx1").select()
And here's how you'd clear one:
checkbox("cbx1").clear()
You can access the current state of a checkbox with isSelected
:
checkbox("cbx1").isSelected should be (true)
Given the following single-selection dropdown list:
<select id="select1"> <option value="option1">Option 1</option> <option value="option2">Option 2</option> <option value="option3">Option 3</option> </select>
You could select Option 2
in either of two ways:
singleSel("select1").value = "option2" singleSel("select1").selection = Some("option2")
To clear the selection, either invoke clear
or set selection
to None
:
singleSel.clear() singleSel("select1").selection = None
You can read the currently selected value of a single-selection list in the same manner as radio buttons:
singleSel("select1").value should be ("option2") singleSel("select1").selection should be (Some("option2"))
If the single-selection list has no selection at all, selection
will return None
whereas value
will throw a TestFailedException
. By using value
, you are indicating you expect a selection, and if there
isn't a selection that should result in a failed test.
Given the following multiple-selection list:
<select name="select2" multiple="multiple"> <option value="option4">Option 4</option> <option value="option5">Option 5</option> <option value="option6">Option 6</option> </select>
You could select Option 5
and Option 6
like this:
multiSel("select2").values = Seq("option5", "option6")
The previous command would essentially clear all selections first, then select Option 5
and Option 6
.
If instead you want to not clear any existing selection, just additionally select Option 5
and Option 6
,
you can use the +=
operator, like this.
multiSel("select2").values += "option5" multiSel("select2").values += "option6"
To clear a specific option, pass its name to clear
:
multiSel("select2").clear("option5")
To clear all selections, call clearAll
:
multiSel("select2").clearAll()
You can access the current selections with values
, which returns an IndexedSeq[String]
:
multiSel("select2").values should have size 2 multiSel("select2").values(0) should be ("option5") multiSel("select2").values(1) should be ("option6")
You can click on any element with “click on
” as shown previously:
click on "aButton" click on name("aTextField")
If the requested element is not found, click on
will throw an exception, failing the test.
Clicking on a input element will give it the focus. If current focus is in on an input element within a form, you can submit the form by
calling submit
:
submit()
You can switch to a popup alert using the following code:
switch to alert
to switch to a frame, you could:
switch to frame(0) // switch by index switch to frame("name") // switch by name
If you have reference to a window handle (can be obtained from calling windowHandle/windowHandles), you can switch to a particular window by:
switch to window(windowHandle)
Similar to what you got in Selenium, you can also switch to active element and default content:
switch to activeElement switch to defaultContent
In real web browser, you can press the 'Back' button to go back to previous page. To emulate that action in your test, you can call goBack
:
goBack()
To emulate the 'Forward' button, you can call:
goForward()
And to refresh or reload the current page, you can call:
reloadPage()
To create a new cookie, you'll say:
add cookie ("cookie_name", "cookie_value")
to read a cookie value, you do:
// If value is undefined, throws TFE right then and there. Never returns null. cookie("cookie_name").value should be ("cookie_value")
In addition to the common use of name-value cookie, you can pass these extra fields when creating the cookie, available ways are:
cookie(name: String, value: String) cookie(name: String, value: String, path: String) cookie(name: String, value: String, path: String, expiry: Date) cookie(name: String, value: String, domain: String, path: String, expiry: Date) cookie(name: String, value: String, domain: String, path: String, expiry: Date, secure: Boolean)
and to read those extra fields:
cookie("cookie_name").value // Read cookie's value cookie("cookie_name").path // Read cookie's path cookie("cookie_name").expiry // Read cookie's expiry cookie("cookie_name").domain // Read cookie's domain cookie("cookie_name").isSecure // Read cookie's isSecure flag
In order to delete a cookie, you could use the following code:
delete cookie "cookie_name"
or to delete all cookies in the same domain:-
delete all cookies
To set the implicit wait, you can call implicitlyWait method:
implicitlyWait(Span(10, Seconds))
It is possible to get the html source of currently loaded page, using:
pageSource
and if needed, get the current URL of currently loaded page:
currentUrl
You can capture screen using the following code:
val file = capture
By default, the captured image file will be saved in temporary folder (returned by java.io.tmpdir property), with random file name ends with .png extension. You can specify a fixed file name:
capture to "MyScreenShot.png"
or
capture to "MyScreenShot"
Both will result in a same file name MyScreenShot.png
.
You can also change the target folder screenshot file is written to, by saying:
capture set "/home/your_name/screenshots"
If you use the page object pattern, mixing trait Page
into your page classes will allow you to use the go to
syntax with your page objects. Here's an example:
class HomePage extends Page { val url = "localhost:9000/index.html" }
val homePage = new HomePage go to homePage
To execute arbitrary JavaScript, for example, to test some JavaScript functions on your page, pass it to executeScript
:
go to (host + "index.html") val result1 = executeScript("return document.title;") result1 should be ("Test Title") val result2 = executeScript("return 'Hello ' + arguments[0]", "ScalaTest") result2 should be ("Hello ScalaTest")
To execute an asynchronous bit of JavaScript, pass it to executeAsyncScript
. You can set the script timeout with setScriptTimeout
:
val script = """ var callback = arguments[arguments.length - 1]; window.setTimeout(function() {callback('Hello ScalaTest')}, 500); """ setScriptTimeout(1 second) val result = executeAsyncScript(script) result should be ("Hello ScalaTest")
You can query for arbitrary elements via find
and findAll
. The find
method returns the first matching element, wrapped in a Some
,
or None
if no element is found. The findAll
method returns an IndexedSeq
of all matching elements. If no elements match the query, findAll
returns an empty IndexedSeq
. These methods allow you to perform rich queries using for
expressions. Here are some examples:
val ele: Option[Element] = find("q")
val eles: IndexedSeq[Element] = findAll(className("small")) for (e <- eles; if e.tagName != "input") e should be ('displayed) val textFields = eles filter { tf.isInstanceOf[TextField] }
To close the current browser window, and exit the driver if the current window was the only one remaining, use close
:
close()
To close all windows, and exit the driver, use quit
:
quit()
Next, learn about other goodies ScalaTest has that can help you address specific problems.


INLINE-CSS
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|
Allegro Animations
1.0
Simple animations made using Allegro graphics library
|
contains lists of Drawable objects and Updateable objects and calls draw and update for their derived objects respectively More...
#include <mySimulator.h>
Public Member Functions | |
| mySimulator (const Display &d, int fps) | |
| Constructor. | |
| void | addDrawable (std::shared_ptr< Drawable > p) |
| takes a smart pointer to Drawable object and pushes it onto the toDraw list More... | |
| void | addUpdateable (std::shared_ptr< Updateable > p) |
| takes a pointer to Updateable object and pushes it onto the to Update list More... | |
| void | updateModel (double dt) |
| takes some amount of time dt and calls each Updateable object's update function More... | |
| void | drawModel () |
| iteratively calls each Drawable object's draw function | |
| Public Member Functions inherited from Simulator | |
| Simulator (const Display &d, int fps) | |
| event storage More... | |
| ~Simulator () | |
| Destroy the Simulator object, free all Allegro resources allocated by constructor. More... | |
| void | run () |
| Invoke to begin the simulation. Main rendering loop. More... | |
contains lists of Drawable objects and Updateable objects and calls draw and update for their derived objects respectively
Definition at line 28 of file mySimulator.h.
|
inline |
takes a smart pointer to Drawable object and pushes it onto the toDraw list
| p | the pointer to the Drawable object |
Definition at line 62 of file mySimulator.h.
|
inline |
takes a pointer to Updateable object and pushes it onto the to Update list
| p | the pointer to the Updateable object |
Definition at line 69 of file mySimulator.h.
|
inlinevirtual |
takes some amount of time dt and calls each Updateable object's update function
| dt | the amount of time passed since the last update occurred |
Implements Simulator.
Definition at line 76 of file mySimulator.h.


Try out our Premium Member services: Virtual Legal Assistant, Query Alert Service and an ad-free experience. Free for one month and pay only if you like it.
IN THE HIGH COURT OF JUDICATURE AT PATNA Civil Writ Jurisdiction Case No.5439 of 2016 ====================================================== Shivam Kumar ... ... Petitioner/s Versus The State Of Bihar and Ors ... ... Respondent/s ====================================================== Appearance : For the Petitioner/s : None. For Bihar State Pollution : Mr. Shivendra Kishore, Sr. Adv. Control Board Mr. Parijat Saurav, Advocate. For the Respondent/s : Mr. Ashok Kumar Pathak, Advocate. ====================================================== CORAM: HONOURABLE MR. JUSTICE SANJAY PRIYA ORAL ORDER
2 10-04-2019 None appears on behalf of the petitioner.
Counsel for the Bihar State Pollution Control Board and State are present.
Counter affidavit has been filed on behalf of the Bihar State Pollution Control Board as well as State. It is mentioned in the counter affidavit filed by the State as well as Pollution Control Board that petitioner has been running the brick kiln since 2003 without obtaining environmental clearance from SEIAA and No Objection Certificate from the concerned department which is utter violation of the law. The petitioner was directed by Memo No. T-172 dated 4.1.2016 to close his brick kiln under the provision of Section 31A of the Air (Prevention and Control of Pollution) Act, 1981 by the Chairman of the State Board. The aforesaid Memo has been Patna High Court CWJC No.5439 of 2016(2) dt.10-04-2019 2/2 enclosed as Annexure R/2-C to the counter affidavit.
Put up this case on 15.4.2019. In the event nobody appears on behalf of the petitioner, the case will be disposed off.
(Sanjay Priya, J) S.Ali/-
U


Modules
Spawns groups of worker processes, sharing all network ports between them with automatic load distribution.
Simple utility methods.
INFOrmation Sciences EXchange format package. Creates and parses standard strings for a constellation of interoperable webapps.
Realtime and peer to peer service layer.
Realtime application gateway and authentication provider. This is the all-purpose module for
writing client applications over the submergence
layer. You may serve an
application from a local cluster or respond to events forwarded from a submergence service. To
access the client library, bundle this module with browserify.
A substation
always represents a single domain (or subdomain) which must appear in the
configuration.


{Graphic Designer, Video Gamer, Future Web Developer}
My name is Johanna Lonn and I'm a graphic designer and aspiring web developer. I'm currently enrolled in Dev Bootcamp – San Francisco. Here you'll find my portfolio, resume, and blog. Feel free to check me out on GitHub, LinkedIn and Twitter.


BeOS Sample Code: Network KitThe Network Kit contains C functions that let you identify remote machines that are connected to the network, and communicate with those machines through the TCP and UDP message protocols. For more information, see the corresponding category in the online Developer Library. Projects
Back to the Sample Code Category Index
BeOS Release 4.5 |


--- layout: post status: publish published: true title: RFID on BizTalk Server 2006 R2 author: display_name: Tomas Restrepo login: tomasr email<EMAIL_ADDRESS>url: http://winterdom.com/ author_login: tomasr author_email<EMAIL_ADDRESS>author_url: http://winterdom.com/ wordpress_id: 488 wordpress_url: http://winterdom.com/2007/02/rfidonbiztalkserver2006r2 date: '2007-02-12 18:10:25 +0000' date_gmt: '2007-02-12 18:10:25 +0000' categories: - BizTalk tags: [] comments: - id: 345 author: R Ogg author_email<EMAIL_ADDRESS>author_url: '' date: '2007-04-05 05:18:14 +0000' date_gmt: '2007-04-05 05:18:14 +0000' content: | I have spent ages trawling for RFID information through MSDN and the Partners site, but haven't found too much! There is mention of Biztalk RFID in various 2006 articles, and also a RFID Infrastructure - the latter sounds particularly interesting to me - from event logging, to RFID device management. If anybody finds any more recent info (and downloads), I would be most grateful. Thanks! - id: 346 author: Tomas Restrepo author_email<EMAIL_ADDRESS>author_url: http://www.winterdom.com/weblog/ date: '2007-04-05 05:21:18 +0000' date_gmt: '2007-04-05 05:21:18 +0000' content: | I think your best bet is to download and try beta 2 for yourself, which was just released and is available to the public. See http://blogs.msdn.com/biztalk_server_team_blog/archive/2007/04/03/public-beta-for-biztalk-2006-r2-has-released.aspx ---
While looking around the MSDN site today, I ran into an interesting article: "BizTalk RFID: Making RFID Deployments Easy, Simple and Economical" by Karen D. Schwartz in the MSDN Manufacturing Industry Architecture center. It introduces the RFID capabilities coming up as one of the most important new features in BizTalk Server 2006 R2.
The article is somewhat light in details, but does introduce the basic architecture of the BizTalk RFID facilities, which I found quite interesting, since I don't really know anything about RFID :-). It does seem to me, however, that the fact that the RFID support gets built right into the integration platform will be a big plus for enterprises adopting the technology.


Croutons
Croutons are an essential addition to many salads. They are delicious and easy to make at home.
Ingredients
- Hearty White Bread
- Extra Virgin Olive Oil
- Spices
Directions
- Preheat oven to 350 degrees Fahrenheit. Gently cut slices of white bread into squares with a chef’s knife. One to two slices is usually enough for one person.
- In a large bowl combine olive oil, spices, and bread squares and gently mix to thoroughly season bread. Spices can be anything but I recommend oregano, paprika, black pepper, garlic powder or freshly minced garlic, and a small pinch of cayenne.
- Spread seasoned bread squares large face down onto a baking sheet evenly and put in oven for 6-8 minutes. Once the bread has crisped flip each square and put back in oven for another 6-8 minutes or until crispy throughout.
- Once fully baked, let rest until cool. These can be eaten immediately or saved in a sandwich bag for later.
Contributors
Recipe tags:
basic
french
salad
fasting


A Lightweight, Easy Static Website Generator
NOTICE
Please use version 2.2.2 and up. Anything older may or may not work.
As of 2.2.3, the command line tools have updated. Please read the website or this document to see the latest CLI commands.
If you have any questions, concerns, or comments, send me an email at<EMAIL_ADDRESS>The purpose of this project was to make an easy way to convert a directory of markdown files to a directory of html files, as I didn't want to have to write out every single html page.
Install the package globally:
npm install sauce-bucket -g
If you want to build a directory into a site, use this command:
sbit -b READ_DIRECTORY_NAME
(by the way, sbit
stands for (s)auce (b)ucket (it))
In order to build correctly, you have to have a file in the parent directory called settings.json
that contains the required settings. Here's a template you can follow:
{
"writeDirectory":"WRITE_DIRECTORY_NAME",
"name":"SITE_NAME",
"baseURL":"URL_THAT_ALL_THE_FILES_WILL_FOLLOW",
"author":"AUTHOR_NAME"
}
Note: the author field is optional
However, to generate a template to start writing out stuff, use this command:
sbit -n WRITE_DIRECTORY_NAME
This will put a few files into the given to get you started on your site. Remember, these files are all templates, and you must actually go into them and fill them out with your data. When you're done, use the command from above to build the raw data into a directory of web ready html files
First, you need to install the Sauce Bucket module:
npm install sauce-bucket --save
Next, import the module:
var sauceBucket = require("sauce-bucket")
Finally, run the convertDirectory()
method. There are a few variables that need to be passed:
sauceBucket.convertDirectory({"readDirectory":READ_DIRECTORY_NAME, "writeDirectory":WRITE_DIRECTORY_NAME, "name":SITE_NAME, "baseURL":URL_THAT_ALL_THE_FILES_WILL_FOLLOW})
For example:
sauceBucket.convertDirectory({"readDirectory":"raw", "writeDirectory":"docs", "name":"Sauce Bucket", "baseURL":"https://alexwaitz.github.io/sauce-bucket"})
The directory you convert should just be a directory of .md
files. Having subdirectories for categories of pages is perfectly fine, and is recommended for a good website layout.
Also, in your main directory, don't have a file named auto_sauce_directory.md
because that's automatically generated as a basic directory list.
Don't like the styling? Simply open up model.html
and edit away! The styling you add will be present in every page of the build.
When you give Sauce Bucket directory names to either read or write to, make sure that the directories already exist, as Sauce Bucket won't make a parent directory for you.
Want to customize your site's html? Just modify the "model.html" file in your parent directory! (Make sure you keep all the ids, or the rendering will break…)
Currently, you're seeing a working demo of the project. Hopefully, as the projects progresses, this page's advancement will also increase.
Click the list on the lower left corner labeled "Page List" to see an automatically created directory of all the site's pages.
MIT


These instructions should get you going when you're ready to submit a program.
Note: it's
important (and helpful) to use the template provided for each assignment.
You're much less likely to miss important requirements if you use it.
The collaboration assignment is a project you'll complete with a partner.
You'll act as employees of a hypothetical software firm facing a couple of problems.
You'll research various software roles and develop a couple of job postings to address the needs of your company.
There are two locations in the course to be aware of for the project:
Here on the Course Info page there is information about the project, a place to let me
know about your partnership situation, and a current list of partners.
The assignment itself has detailed instructions
Let me know what questions you have about the project and how I can help.
Well, it is a "collaboration" assignment and I strongly prefer you work with a partner.
Please contact me if this isn't feasible for you.
Also note there are details about the project posted on the Announcements page
Yes, there is a comprehensive final exam (assignment 03.06 Segment One Exam).
It is password-protected and should be proctored by your mentor
The Module 1 exam and final exam are password-protected.
Each exam should be proctored and passwords are only given to mentors.
Please arrange an appropriate time with your mentor when you are ready for an exam.


Galaxian
1979 | Namco
A list of games that influenced my game design decisions, assembled in order of discovery.
1979 | Namco
1985 | Nintendo Creative Department
1983 | Namco
1983 | Hudson Soft
1985 | Namco
1980 | Namco
1984 | Various
1987 | Nintendo Creative Department
1984 | Nintendo R&D1t
1985 | Nintendo R&D1t
1986 | Toaplan
1989 | Brøderbund
1992 | Konami
1994 | Shiny Entertainment
1997 | Namco
1997 | Core Design
1999 | Ubisoft Reflections
1996 | SNK
1999 | Team17
1996 | Westwood Studios
1998 | Electronic Arts
2002 | Rockstar North | RenderWare
2003 | PopCap Games
2004 | EA Black Box
2009 | Maxis
2004 | Neversoft
2004 | Rockstar North | RenderWare
2006 | SCE Japan Studio
1995 | Sega Technical Institute
2007 | Ubisoft Montreal | Scimitar
2008 | Criterion Games
2007 | EA Black Box
2008 | Media Molecule
2006 | Epic Games
2006 | Nintendo EAD
2010 | Vlambeer | GameMaker: Studio
2009 | Rovio Entertainment
2009 | PopCap Games
2010 | Electronic Arts
2011 | Mojang
2008 | EA DICE | Unreal Engine 3
2006 | Clover Studio
2008 | Mossmouth, LLC | GameMaker Studio
2012 | Thatgamecompany | PhyreEngine
2008 | SCE Studio Liverpool
2011 | Ubisoft Montpellier | UbiArt Framework
2012 | Polytron Corporation
2011 | Re-Logic
2014 | Messhof
2009 | Frozenbytes
2013 | Matt Makes Games
2014 | Ustwo Games | Unity
2015 | Spiderling Studios | Unity
2013 | Ubisoft Reflections | Unity
2015 | Hopoo Games | Game Maker
2016 | Moppin
2015 | Psyonix | Unreal Engine 3
2015 | Brace Yourself Games | Monkey X
2013 | Valve Corporation | Source
2008 | Maxis
2015 | Colossal Order | Unity
2011 | Ubisoft Montpellier | LyN
2016 | Giant Squid Studios | Unreal Engine 4
2009 | Dmytry Lavrov
2014 | Lucid Games
2017 | David OReilly | Unity
2017 | Ed Key, David Kanaga
2017 | Realmforge Studios | Unity
2016 | Superhot Team
2013 | Blizzard Entertainment


As of November 19, 1997, Total Renal Care Holdings, Inc. owns and
operates 194 free-standing kidney dialysis
centers and home peritoneal dialysis programs in 18 states as well as Washington, D.C.,
Puerto Rico, Guam and Europe, serving approximately 14,900 patients. TRC also
provides acute hemodialysis services to in-patients at 119 hospitals. The company
operates ESRD laboratory and pharmacy facilities as well as vascular access management,
transplant services and ESRD clinical research programs.
TRC's aggressive and disciplined growth strategy is to :
1. develop strong regional clusters of facilities in specific
markets through acquisitions, de Novo developments and hospital
alliances;
2. use a strong local and regional presence to develop unique
partnerships with managed care organizations and our affiliated
physicians;
3. focus on Quality Management, Clinical Information Systems and
other clinical programs to provide the highest quality care, making
TRC the quality leader in the industry; and
4. successfully expand its range of ancillary services to provide
"total renal care", which now includes ESRD laboratory, ESRD oral
pharmacy, vascular access management and pre/post-transplant management
services.
The Company began implementing this strategy after an August 1994
restructuring, and through May 31, 1997, has added 128 facilities,
including 66 during fiscal 1996.
TRC's management team is led by Victor M.G. Chaltiel, who has
30 years of health care experience, including 18 years with Baxter
International, where he was instrumental in the development and
worldwide commercialization of Continuous Ambulatory Peritoneal
Dialysis, the principal modality for home dialysis.
Victor M.G. Chaltiel
Chairman of the Board,
President and Chief Executive Officer
John E. King
Vice President and Chief Financial Officer
Lois A. Mills, RN
Vice President Operations, Western Division
Sidney J. Kernion
Vice President Operations, Eastern Division
Leonard W. Frie
Executive Vice President and Chief Operating Officer
Jack M. Silver
Vice President, Information Systems
Stan M. Lindenfeld, MD
Vice President, Quality Management
and Integrated Programs
Mary Ellen Chambers, RN
Vice President, Managed Care
Barry C. Cosgrove, Esq.
Vice President and General Counsel
BOARD OF DIRECTORS
Victor M.G. Chaltiel
Chairman of the Board,
President and Chief Executive Officer
Maris Andersons
Senior Vice President and
Senior Advisor Corporate Finance
Tenet Healthcare Corporation
Peter I. Grauer
Managing Director
Donaldson, Lufkin & Jenrette
Merchant Banking, inc.
Shaul G. Massry, M.D.
Professor of Medicine, Physiology and Biophysics
Chief, Division of Nephrology
University of Southern California, School of Medicine
Regina E. Herzlinger
Nancy R. McPherson Professor of Business Administration
Chair at the Harvard Business School


Santa Anita Park stakes schedule leads off with Malibu, La Brea
by Santa Anita PublicitySanta Anita Park, which will open for its 83rd Winter/Spring Meeting as is tradition on Dec. 26, has announced a complete stakes schedule through closing day, June 21.
The slate, which includes a total of 93 added-money races, kicks off with pair of Grade 1 stakes on opening day: the $300,000 Malibu, for 3-year-olds at seven furlongs, and the $300,000 La Brea, for 3-year-old fillies at the same distance.
The Malibu and La Brea will again be complemented on opening day by the Grade 2, $200,000 San Antonio Stakes, the Grade 2, $200,000 Mathis Brothers Mile and the $75,000 Lady of Shamrock Stakes.
The Grade 1, $300,000 American Oaks, for 3-year-old fillies at a mile and a quarter on turf, will serve as Santa Anita’s final top-level offering this year on Dec. 28.
First run in February of 1935, the Grade 1, $600,000 Santa Anita Handicap, which was won this year by Hronis Racing’s Gift Box, will be contested for the 83rd time on March 7.
The Grade 1, $1 million Santa Anita Derby, which has produced a total of 18 Kentucky Derby winners and three Triple Crown champions, will be run on Saturday, April 4.
SANTA ANITA’S GRADE 1 STAKES ROSTER
Dec. 26 $300,000 Malibu Stakes
Dec. 26 $300,000 La Brea Stakes
Dec. 28 $300,000 American Oaks
March 7 $600,000 Santa Anita Handicap
March 7 $400,000 Frank E. Kilroe Mile
March 14 $400,000 Beholder Mile
April 4 $1 million Santa Anita Derby
April 4 $400,000 Santa Anita Oaks
May 25 $500,000 Gold Cup at Santa Anita
May 25 $500,000 Shoemaker Mile
May 25 $500,000 Gamely Stakes


| S | stats toolbox needed | I | interactive (user input required) |
| B | bioinformatics toolbox needed | M | matlab needed (will not work in octave) |
| O | optimization toolbox needed | W | windows needed (will not work in linux) |
| X | currently broken | * | slow (two stars indicates very slow) |
| FILE | DESCRIPTION | TAGS |
|---|---|---|
| studentCondition | p(xh|xv=visValues) | |
| studentCreate | Constructor for a student T distribution | |
| studentFit | Fit multivariate student T distribution | |
| studentLogprob | Multivariate student T distribution, log pdf | |
| sub\studentFitEm | Fit multivariate student T distribution usign EM or ECME. | |
| sub\studentProb | Student probability | |
| sub\tcdfPMTK | Replacement for the stats toolbox tcdf (Student's T CDF) | |
| sub\tinvPMTK | Replacement for the stats toolbox tinv function |


Bahtera organic was a small family farm at beginning. Bahtera Yokino was the 9th generation of family who rise the this small farm into largest best meat supplier. Over 30 years Bahtera serving the best quality and cleanliness for many popular restaurants.
Bahtera has professional chefs and butchers. We offer cutting technique for each meat slices give our customer best experiences. We provide unique packaging for hygiene products, la carte boxing and free gift for our customer. To strengthen relationships we open our farm for education purpose.
Today we open our order by online systems. Fast order, better and easy service. We build our ordering with tracking system. You can monitor your order realtime.


PxPhysXConfig.h File Reference
#include "
common/PxPhysXCommonConfig.h
"
This graph shows which files directly or indirectly include this file:
Go to the source code of this file.
include
PxPhysXConfig.h
Copyright © 2008-2021 NVIDIA Corporation, 2788 San Tomas Expressway, Santa Clara, CA 95051 U.S.A. All rights reserved.
www.nvidia.com


Hrutik,
I just want you to know that you mean the world to me.
I run to you for every small thing and honestly I
couldn't have asked for a better companion. Okay,
I forgive you for teasing me all the time because the
best moments in my life were with you and here's
to making many more.Love you.Happy Birthday!❤


Home
About
Projects
▼
Stratospheric aerosol geoengineering
Stratosphere and climate change
Water vapour and lapse rate feedbacks
Publications
Presentations
Blog
{{ content }}


Taobao Link Converter (Beta Version)
The beta removes spaces from links, and converts Superbuy links. Click 'Show options' to see the options This website converts any Taobao link into its Chinese mainland desktop version. Please enter links separately on each line in the textarea below. You can click on the links to open them. You may need to 'Always allow pop-ups' if you are opening multiple links with the 'Open Links' button. Show options Hide options
Valid Links
Invalid Links
To report a bug or suggest a feature, please message /u/TaobaoTools on Reddit or fill in this form.


Click here to download the file
This is to be done in class with image posted here for reference but in case you miss the activity that generates it. Take 10 minutes and figure out the fields and relationships of this data:
- Courses
- {come up with the relationships}
- {come up with the fields}
- Faculty
- {come up with the relationships}
- {come up with the fields}
- Rooms
- {come up with the fields}
- You are the site builder that works in the organization who has been doing Grav / WP
- You’ve starting to do websites that require a lot of data and users and you don’t think that WordPress is the right fit anymore
- Your Project Manager (with the same name as you, weird huh?
) agrees but has never used Drupal and is concerned about you being able to handle it
- They give you a map of the data model and ask you to model the information in Drupal and create a displays that pull data together
- "NO problem boss with my same name!" - You say out-loud, bizarre way to address a boss but hey...
- "I can figure Drupal out and win the lottery when it comes to Site Building. Sucker! This is my meal ticket outta this joint!" (hopefully you say this in your head)
- Create a Drupal site that accurately represents the data model that we’ve agreed on in class (on website / slack)
- Model these entities:
- Create 5 courses on the site
- either your own or make them up whatever
- Create rooms and faculty and associate them with these courses so all courses have faculty and a room
- Create a View
that shows the list of courses
- Title this schedule
- Make sure it shows up in the menu bar
- Make it display as a table
- Add fields that are relevant for people viewing the site
- BONUS 2PTS: Create a View showing a list of the faculty
- Title this Our Faculty
- Make sure it shows up in the menu bar
- Make it display as a grid / list
- Add a field for photo to the instructor type
- Use a “Relationship” in the view in order to show the courses faculty members are teaching as well as their name and photo
- Create your Drupal site building out the view and content types that we chose to model our data off of this week
- Create a Home page in the menu that includes:
- 500 words on why Drupal is the choice for big organizations
- Links to 3 resources backing this claim
- A link to your YouTube video
- Record the video demonstrating the following techniques (or both if you like)
- How to create a Content Type
and Add Fields
then Create Content
of that type and connect the concepts for viewers of your video
OR
- How to create views, adding filters and sorting to the view then showing the view in use with data present in the site and explain what the View
is doing that makes it so impressive
- Post your link to your site in: #lab7-drupal
- Did you create a Drupal site in Reclaim and post your link to the channel (1pts)
- Did you create content types that match our data model? (3pts)
- Did you create the View
that matches the requested data to display? (3pts)
- Did you record a video that demonstrates site building technique (3pts)
- BONUS 2PTS: Did you build the more complex view to sort faculty members with (trolly or real) photos included
10 points total with 2 possible bonus points


Creating efficient icon font class styles
Creating class-based icon font deployment can be tedious. Each icon will need an individual class assignment in order to display properly. This can also result in needless repetition of code through visual styling appearing in each declaration. The upside is that you can use class names that are meaningful rather than the encoding values, which makes it easier to remember which class to apply for each icon. You can make this process more efficient through the use of attribute selectors. These selectors allow you to write class definitions that chain together with prefixes and suffixes to apply icons. Parent classes can assign font-family declarations and normalize styling, while individual suffixes can assign specific icons. You can take this even further by adding specific visual styling suffixes as well.
Example
*[class*="icon"]:before {
font-family: 'icon font';
*/ normalize */
}
*[class*="-search"]:before {
content: '\e001';
}
*[class*="-big"]:before {
font-size: 2em;
}
-------------------------------

Exercise
Display the search and maps icon on one row and the search icon at the "big" size on another row.


Across: 1. Criminal led after ultimately dubious victory and deceitful conduct (7) 5. A tense drama in chamber? (6) 9. Takes in what is owed, including party leadership (5) 10. One given job of stirring pee in a pot (9) 11. Piss quietly taken during piss-poor outcome of 1975 crisis (9) 12. Tired writer in the way (5) 13. He said he could secure big loans through a link arranged across border (8) 14. Politician with oddly formal sneer (6) 17. see 29 19.  Kick out the victorious group? (5) 24. During catastrophe, no men accurately observed processes (9) 26. I lengthen parts to fill in (9) 27. Witnesses generally take these as hot stuff (5) 28. Oily bondage warriors? (6) 29,17. What 19 drew on to solve 2 was worse... perverse system! (7 6) Down: 1. Allied soldiers in dead end, denied openings (5) 2. Fiend-like, 5 across earnestly starts intractable conflict (7) 3. One who takes the piss and captures the spirit of the thing? (9) 4. Leap about and perform "Ticking away..." (8) 5. Drink and travel which can be blocked by 5 across (6) 6. Fixers consumed with anxiety? (5) 7. A sight at the racetrack: 19, finally out, shows signs of inebriation perhaps (7) 8. Down time or hesitation said to be what brings back fresh condition (8) 13. Avoided including monarch, with detachment of leader to be preserved (8) 15. Managed firm, or turned us bitter? (9) 16. Vice regal chap largely riding over norms (8) 18. Legendary leader sacked with 14 rising (7) 20. Constituent pieces of core let loose (7) 21. In a way, you start but rarely finish anything with this (6) 23. Original great leader of Australia replaced by one who wears different stripes (5) 25. A small land where politicians reach across in bipartisan cooperation (5)


States office strategy unveiled
GOVERNMENT staff will be moved out of 14 offices in a move which could save up to £7 million a year.
by Michael MorrisThe plan, which would see the government consolidate its current 21 offices into seven blocks, would mean 1,600 civil servants moving. No site as yet been identified.
Chief Minister John Le Fondré said this could release valuable sites for affordable housing, keyworker accommodation and other development.
The main government offices are currently based in Broad Street after moving out of Cyril Le Marquand House earlier this year.
Senator Le Fondré said: 'There has been woeful underinvestment in the government’s office estate over many years and this government is sorting out that legacy. Too many of our staff work in a poor-quality environment in old offices, with poor wellbeing facilities, poor energy efficiency and limited disability access. In short, they are no longer fit for purpose.
'Consolidating our office estate will release sites for much-needed affordable housing and other development and could save up to £7 million a year of taxpayers’ money, while providing a modern working environment for our staff.
'This is another example of how this government proposes to invest for long-term benefits, modernising, improving and delivering better value for money.'
The States will vacate the following:
• Cyril Le Marquand House
• South Hill
• Philip Le Feuvre House
• Huguenot House
• Maritime House
• Jubilee Wharf
• Maison Le Pape
• Le Bas
• Highlands administrative offices (not Highlands College).
And in the next four or five years will end the lease of:
• Broad Street
• The Parade
• Durell House
• Eagle House
• Liberté House
• Bermuda House.